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Tamar Weinberger, Scott Sicherer The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Kravis Children’s Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA Abstract: Tree nut (TN) allergy is common and often severe. It has become an important health concern as availability and consumption have increased. Prevalence varies by age and geographic region and appears to have increased in children. Accidental ingestion of TNs is common. Unfortunately, there is a lower likelihood of resolution of TN allergy, roughly 10%. TN-specific skin tests and serum immunoglobulin E levels can help aid in the diagnosis of TN allergy, but a careful medical history is important because a positive test in isolation is not typically diagnostic. Component-resolved diagnostic tests are being increasingly utilized and may improve accuracy. Management consists of strict avoidance of the causal nut(s) and prompt treatment of symptoms upon accidental exposure. A specific consideration with regard to the management of TN allergy is the decision to avoid all TNs or only the TNs to which a patient is clinically allergic. There are currently no data on the primary or secondary prevention of TN allergy. Treatment strategies are being evaluated. Keywords: food allergy, anaphylaxis, food allergens, food hypersensitivity, cross reactivity, component resolved diagnostics

The unconventional superconductor UTe2 exhibits numerous signatures of spin-triplet superconductivity--a rare state of matter which could enable quantum computation protected against decoherence. UTe2 possesses a complex phase landscape comprising two magnetic field-induced superconducting phases, a metamagnetic transition to a field-polarized state, along with pair- and charge-density wave orders. However, contradictory reports between studies performed on UTe2 specimens of varying quality have severely impeded theoretical efforts to understand the microscopic origins of the exotic superconductivity. Here, we report a comprehensive suite of high magnetic field measurements on a generation of pristine quality UTe2 crystals. Our experiments reveal a significantly revised high magnetic field superconducting phase diagram in the ultraclean limit, showing a pronounced sensitivity of field-induced superconductivity to the presence of crystalline disorder. We employ a Ginzburg-Landau model that excellently captures this acute dependence on sample quality. Our results suggest that in close proximity to a field-induced metamagnetic transition the enhanced role of magnetic fluctuations--that are strongly suppressed by disorder--is likely responsible for tuning UTe2 between two distinct spin-triplet superconducting phases. [ABSTRACT FROM AUTHOR]

The unconventional superconductor UTe2 exhibits numerous signatures of spin-triplet superconductivity--a rare state of matter which could enable quantum computation protected against decoherence. UTe2 possesses a complex phase landscape comprising two magnetic field-induced superconducting phases, a metamagnetic transition to a field-polarized state, along with pair- and charge-density wave orders. However, contradictory reports between studies performed on UTe2 specimens of varying quality have severely impeded theoretical efforts to understand the microscopic origins of the exotic superconductivity. Here, we report a comprehensive suite of high magnetic field measurements on a generation of pristine quality UTe2 crystals. Our experiments reveal a significantly revised high magnetic field superconducting phase diagram in the ultraclean limit, showing a pronounced sensitivity of field-induced superconductivity to the presence of crystalline disorder. We employ a Ginzburg-Landau model that excellently captures this acute dependence on sample quality. Our results suggest that in close proximity to a field-induced metamagnetic transition the enhanced role of magnetic fluctuations--that are strongly suppressed by disorder--is likely responsible for tuning UTe2 between two distinct spin-triplet superconducting phases. [ABSTRACT FROM AUTHOR]

The heavy fermion paramagnet UTe2 exhibits numerous characteristics of spin-triplet superconductivity. Efforts to understand the microscopic details of this exotic superconductivity have been impeded by uncertainty regarding the underlying electronic structure. Here we directly probe the Fermi surface of UTe2 by measuring magnetic quantum oscillations in pristine quality crystals. We find an angular profile of quantum oscillatory frequency and amplitude that is characteristic of a quasi-2D Fermi surface, which we find is well described by two cylindrical Fermi sheets of electron- and hole-type respectively. Additionally, we find that both cylindrical Fermi sheets possess considerable undulation but negligible small-scale corrugation, which may allow for their near-nesting and therefore promote magnetic fluctuations that enhance the triplet pairing mechanism. Importantly, we find no evidence for the presence of any 3D Fermi surface sections. Our results place strong constraints on the possible symmetry of the superconducting order parameter in UTe2. A. G. Eaton et al. directly probe the Fermi surface of the candidate triplet superconductor UTe2 by measuring magnetic quantum oscillations in ultra-pure crystals. By comparison with model calculations, the data are found to be consistent with a Fermi surface that consists of two cylindrical sections of electron and hole-type respectively. [ABSTRACT FROM AUTHOR]

Katz's quantitative modification of Angle's occlusion classification has been found to have a high intra-examiner agreement among orthodontists. In the present study an attempt was made to introduce a 'combined' system comprising Katz's modification and overjet/overbite millimetric measurements in order to attain a more meaningful and complete classification of malocclusion than is presently available. A group of 32 raters (16 orthodontists and 16 senior-year students) examined 14 study models twice, with an interval of at least 1 month between examinations. In total, 448 x 2 determinations were performed. The percentage agreement of the Angle, the modified and the 'combined' systems, as well as the performance of the orthodontists versus the students were compared using the paired t-test. The percentage agreement obtained by both orthodontists and students was highest for Katz's modification and lowest for Angle's method. The overjet/overbite measurements affected the agreement in Katz's modified technique. The orthodontists surpassed the students with respect to Angle's method (P = 0.025), whereas no statistically significant difference existed between orthodontists and students regarding Katz's modification or the 'combined' system. It is concluded that in view of the relatively low agreement in the 'combined' method, it cannot be recommended for clinical application. The Katz's modified method, on the other hand, may be a helpful supplement to Angle's classification. [ABSTRACT FROM AUTHOR]

Purpose: Herbal medicines are widely used for the treatment of pain, although there is not much information on their effectiveness. This study was designed to evaluate the effectiveness of willow (Salix) bark extract, which is widely used in Europe, for the treatment of low back pain.Subjects and Methods: We enrolled 210 patients with an exacerbation of chronic low back pain who reported current pain of 5 or more (out of 10) on a visual analog scale. They were randomly assigned to receive an oral willow bark extract with either 120 mg (low dose) or 240 mg (high dose) of salicin, or placebo, with tramadol as the sole rescue medication, in a 4-week blinded trial. The principal outcome measure was the proportion of patients who were pain-free without tramadol for at least 5 days during the final week of the study.Results: The treatment and placebo groups were similar at baseline in 114 of 120 clinical features. A total of 191 patients completed the study. The numbers of pain-free patients in the last week of treatment were 27 (39%) of 65 in the group receiving high-dose extract, 15 (21%) of 67 in the group receiving low-dose extract, and 4 (6%) of 59 in the placebo group (P <0.001). The response in the high-dose group was evident after only 1 week of treatment. Significantly more patients in the placebo group required tramadol (P <0.001) during each week of the study. One patient suffered a severe allergic reaction, perhaps to the extract.Conclusion: Willow bark extract may be a useful and safe treatment for low back pain. [ABSTRACT FROM AUTHOR]