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827 results on '"Weinberg, Laurence"'

1. Methadone in combination with magnesium, ketamine, lidocaine, and dexmedetomidine improves postoperative outcomes after coronary artery bypass grafting: an observational multicentre study

Author

Weinberg, Laurence, Johnston, Samuel, Fletcher, Luke, Caragata, Rebecca, Hazard, Riley H., Le, Peter, Karp, Jadon, Carp, Bradly, Sean Yip, Sui Wah, Walpole, Dominic, Shearer, Nicholas, Neal-Williams, Tom, Nicolae, Robert, Armellini, Angelica, Matalanis, George, Seevanayagam, Siven, Bellomo, Rinaldo, Makar, Timothy, Pillai, Param, Warrillow, Stephen, Ansari, Ziauddin, Koshy, Anoop N., Lee, Dong-Kyu, and Yii, Michael

Published
2024
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11. Low tidal volume ventilation for patients undergoing laparoscopic surgery: a secondary analysis of a randomised clinical trial

Author

Karalapillai, Dharshi, Weinberg, Laurence, Neto, Ary Serpa, Peyton, Philip J., Ellard, Louise, Hu, Raymond, Pearce, Brett, Tan, Chong O., Story, David, O’Donnell, Mark, Hamilton, Patrick, Oughton, Chad, Galtieri, Jonathan, Wilson, Anthony, Liskaser, Grace, Balasubramaniam, Ajay, Eastwood, Glenn, Bellomo, Rinaldo, and Jones, Daryl A.

Published
2023
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15. Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial

Author

Chadban, Steven J, Ying, Tracey, Gracey, David, Aouad, Leyla, Wyburn, Kate, Habijanec, Beatriz, Yeo, Hee-eun (Ellen), Lin, Lin, Rosales, Brenda, Hudaly, Julia, Rodrigues, Vera, Wong, Germaine, O'Connell, Philip, Murie, Penelope, Endre, Zoltan, Gray, Zuzana, Spicer, Rebecca, Durkan, Anne, Fahim, Magid A, Jegatheesan, Dev, Leary, Diana, Guo, Yujing (Sarah), Coburn, Amanda, Irvine, Rachael, McTaggart, Steven, Crawford, Aimee, Coates, P Toby, Hockley, Bronwyn, Fischer, Karen, Weinberg, Laurence, Mount, Peter, Baulch, Sarah, Claxton, Gayle, Harris, Saskia, Sidiropoulos, Sofia, Veenendal, Marieke, Kanellis, John, Barbis, Rita, Goodman, David, Brahmbhatt, Anjalee, Le Page, Amelia, Jamboti, Jagadish, Chiam, Anna, Warger, Anne, Lim, Wai H, Collins, Michael, Pilmore, Helen, Dittmer, Ian, Manley, Paul, Ahmed, Jafar, McConnochie, Rachael, Newby, Lynette, Chen, Yan, Simmonds, Catherine, Irvine, John, Usher, Jenny, Clark, Carolyn, Beckett, Claire, Prestidge, Chanel, Erickson, Robin, Rea, Miriam, Scherring, Claire, Collins, Michael G, Pascoe, Elaine M, Hawley, Carmel M, Johnson, David W, Varghese, Julie, Hickey, Laura E, Clayton, Philip A, Dansie, Kathryn B, McConnochie, Rachael C, Vergara, Liza A, Kiriwandeniya, Charani, Reidlinger, Donna, Mount, Peter F, McArthur, Colin J, Endre, Zoltan H, Howard, Kirsten, Howell, Martin, Jamboti, Jagadish S, Laurence, Jerome M, McTaggart, Steven J, O'Connell, Philip J, and Pilmore, Helen L

Published
2023
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18. Contributors

Author

Abdi, Salahadin, primary, Afonso, Anoushka M., additional, Aloia, Thomas A., additional, Baldini, Gabriele, additional, Banchs, Jose, additional, Baptista-Hon, Daniel T., additional, Basen-Engquist, Karen, additional, Bello, Rosalind S., additional, Ben-Eliyahu, Shamgar, additional, Bergdahl, Celena Scheede, additional, Bhatnagar, Sushma, additional, Botdorf, Joshua, additional, Botha, Christelle, additional, Brown, David L., additional, Buggy, Donal J., additional, Burbury, Kate L., additional, Butler, Joseph, additional, Cahill, Ronan, additional, Carli, Franco, additional, Carton, Meghan, additional, Cata, Juan P., additional, Connolly, Cara, additional, Corrales, German, additional, Cortes, Jose, additional, Craven, Kimberly D., additional, Crommett, John Wilson, additional, Crosby, Kristin P., additional, Guzman, Luis Felipe Cuellar, additional, Dabo-Trubelja, Anahita, additional, Dang, Anh Quynh, additional, De Camilli, Alessandro R., additional, Desai, Madhavi D., additional, Dhesi, Jugdeep, additional, Doctor, Jeson R., additional, Downs, Jennifer S., additional, Dubowitz, Julia A., additional, Echeverry, German, additional, Enlund, Mats, additional, Ewing, Linette, additional, Finnerty, Dylan, additional, Domgue, Joël Fokom, additional, Frenzel, John, additional, Gallagher, Colleen M., additional, García-Ortega, Dorian Yarih, additional, Gerstman, Michelle, additional, Ghoshal, Arunangshu, additional, Gottumukkala, Vijaya N.R., additional, Grocott, Michael P.W., additional, Guerra-Londono, Carlos E., additional, Gupta, Sushan, additional, Gyorki, David E., additional, Hales, Tim G., additional, Hawk, Ernest, additional, Heriot, Alexander G., additional, Herman, Joseph M., additional, Hiller, Jonathan G., additional, Hubbard, Ruth E., additional, Ismail, Hilmy, additional, Itzep, Nelda, additional, Jasper, Emily, additional, Javed, Saba, additional, Jha, Bhawna, additional, Jhanji, Shaman, additional, Jones, Daryl, additional, Kapoor, Ravish, additional, Khan, Faraz, additional, Killinger, James S., additional, Koschel, Samantha, additional, Kotin, Alan, additional, Kulkarni, Atul Prabhakar, additional, La Caze, Adam, additional, Lawrentschuk, Nathan, additional, Leddy, Lauren Adrienne, additional, Ledet, Celia R., additional, Levett, Denny Z.H., additional, Leung, Debra, additional, Lin, Hui-Shan, additional, Lewis, Alexandra L., additional, Ma, Daqing, additional, Madden, Kevin, additional, Maitra, Anirban, additional, Maresso, Karen Colbert, additional, Mascarenhas, Jennifer, additional, McQueen, K. A. Kelly, additional, Mejia, Rodrigo, additional, Miles, Lachlan F., additional, Mohiuddin, Sana, additional, Molena, Daniela, additional, Moo, Tracy-Ann, additional, Moody, Karen, additional, Murphy, Declan G., additional, Myatra, Sheila Nainan, additional, Nates, Joseph L., additional, Nelson, Jonas A., additional, Eochagáin, Aisling Ní, additional, O’Connor, Ellen, additional, Okhuysen-Cawley, Regina, additional, Owusu-Agyemang, Pascal, additional, Pantvaidya, Gouri H., additional, Papadopoulos, Pamela C., additional, Parat, Marie-Odile, additional, Partridge, Judith, additional, Patel, Sephalie, additional, Patel, Vikram B., additional, Perry, Nicholas, additional, Polanco, Thais O., additional, Popovich, Shannon M., additional, Poulogiannis, George, additional, Rafael, Perez-Gonzalez Oscar, additional, Rampes, Sanketh, additional, Rao, Krithika S., additional, Raty, Sally Radelat, additional, Razvi, Shehla, additional, Reid, Natasha, additional, Ricon-Becker, Itay, additional, Riedel, Bernhard J., additional, Roarty, Emily B., additional, Rodriguez, Maria Alma, additional, Russo, Suzanne, additional, Saeed, Iqira, additional, Sahai, Sunil K., additional, Salins, Naveen, additional, Sathianathen, Niranjan, additional, Seth, Shveta, additional, Shaw, Paul N., additional, Sherwin, Aislinn, additional, Shete, Sanjay, additional, Shi, Qiuling, additional, Shields, Conor, additional, Tan, Jo-Lynn, additional, Tokita, Hanae K., additional, Wall, Tom, additional, Walters, Ronald S., additional, Wang, Xin Shelley, additional, Ward, Phil, additional, Waylen, Anna Louise, additional, Weinberg, Laurence, additional, Wichmann, Matthias Wilhelm, additional, Wigmore, Timothy, additional, Yusuf, Syed Wamique, additional, Zaky, Wafik, additional, and Zheng, Gang, additional

Published
2023
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20. The effect of an intraoperative patient-specific, surgery-specific haemodynamic algorithm in improving textbook outcomes for hepatobiliary–pancreatic surgery: a multicentre retrospective study

Author

Carp, Bradly, primary, Weinberg, Laurence, additional, Fletcher, Luke R., additional, Hinton, Jake V., additional, Cohen, Adam, additional, Slifirski, Hugh, additional, Le, Peter, additional, Woodford, Stephen, additional, Tosif, Shervin, additional, Liu, David, additional, Muralidharan, Vijaragavan, additional, Perini, Marcos V., additional, Nikfarjam, Mehrdad, additional, and Lee, Dong-Kyu, additional

Published
2024
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27. Management of Acute Coronary Syndromes in Older People: Comprehensive Review and Multidisciplinary Practice-Based Recommendations.

Author

Narendren, Ahthavan, Whitehead, Natalie, Burrell, Louise M., Yudi, Matias B., Yeoh, Julian, Jones, Nicholas, Weinberg, Laurence, Miles, Lachlan F., Lim, Han S., Clark, David J., Al-Fiadh, Ali, Farouque, Omar, and Koshy, Anoop N.

Subjects
OLDER people, ACUTE coronary syndrome, OLDER patients, OCTOGENARIANS, CORONARY artery disease
Abstract

Managing health care for older adults aged 75 years and older can pose unique challenges stemming from age-related physiological differences and comorbidities, along with elevated risk of delirium, frailty, disability, and polypharmacy. This review is aimed at providing a comprehensive analysis of the management of acute coronary syndromes (ACS) in older patients, a demographic substantially underrepresented in major clinical trials. Because older patients often exhibit atypical ACS symptoms, a nuanced diagnostic and risk stratification approach is necessary. We aim to address diagnostic challenges for older populations and highlight the diminished sensitivity of traditional symptoms with age, and the importance of biomarkers and imaging techniques tailored for older patients. Additionally, we review the efficacy and safety of pharmacological agents for ACS management in older people, emphasizing the need for a personalized and shared decision-making approach to treatment. This review also explores revascularization strategies, considering the implications of invasive procedures in older people, and weighing the potential benefits against the heightened procedural risks, particularly with surgical revascularization techniques. We explore the perioperative management of older patients experiencing myocardial infarction in the setting of noncardiac surgeries, including preoperative risk stratification and postoperative care considerations. Furthermore, we highlight the critical role of a multidisciplinary approach involving cardiologists, geriatricians, general and internal medicine physicians, primary care physicians, and allied health, to ensure a holistic care pathway in this patient cohort. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Association of perioperative transfusion of fresh frozen plasma and outcomes after cardiac surgery.

Author

Hinton, Jake V., Xing, Zhongyue, Fletcher, Calvin, Perry, Luke A., Karamesinis, Alexandra, Shi, Jenny, Penny‐Dimri, Jahan C., Ramson, Dhruvesh, Coulson, Tim G., Segal, Reny, Smith, Julian A., Williams‐Spence, Jenni, Weinberg, Laurence, and Bellomo, Rinaldo

Subjects
PLASMA products, CARDIAC surgery, PROPENSITY score matching, CHEST tubes, ODDS ratio, BLOOD platelet transfusion
Abstract

Background: Fresh frozen plasma (FFP) transfusion is used to manage coagulopathy and bleeding in cardiac surgery patients despite uncertainty about its safety and effectiveness. Methods: We performed a propensity score matched analysis of the Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database including patients from 39 centres from 2005 to 2018. We investigated the association of perioperative FFP transfusion with mortality and other clinical outcomes. Results: Of 119,138 eligible patients, we successfully matched 13,131 FFP recipients with 13,131 controls. FFP transfusion was associated with 30‐day mortality (odds ratio (OR), 1.41; 99% CI, 1.17–1.71; p <.0001), but not with long‐term mortality (hazard ratio (HR), 0.92; 99% CI, 0.85–1.00; p =.007, Holm–Bonferroni α = 0.0004). FFP was also associated with return to theatre for bleeding (OR, 1.97; 99% CI, 1.66–2.34; p <.0001), prolonged intubation (OR, 1.15; 99% CI, 1.05–1.26; p <.0001) and increased chest tube drainage (Mean difference (MD) in mL, 131; 99% CI, 120–141; p <.0001). It was also associated with reduced postoperative creatinine levels (MD in g/L, −6.33; 99% CI, −10.28 to −2.38; p <.0001). Conclusion: In a multicentre, propensity score matched analysis, perioperative FFP transfusion was associated with increased 30‐day mortality and had variable associations with secondary clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Baseline Characteristics and Representativeness of Participants in the BEST-Fluids Trial: A Randomized Trial of Balanced Crystalloid Solution Versus Saline in Deceased Donor Kidney Transplantation

Author

Collins, Michael G., Fahim, Magid A., Pascoe, Elaine M., Hawley, Carmel M., Johnson, David W., Varghese, Julie, Hickey, Laura E., Clayton, Philip A., Gill, John S., Dansie, Kathryn B., McConnochie, Rachael C., Vergara, Liza A, Kiriwandeniya, Charani, Reidlinger, Donna, Mount, Peter F., Weinberg, Laurence, McArthur, Colin J., Coates, P. Toby, Endre, Zoltan H., Goodman, David, Howard, Kirsten, Howell, Martin, Jamboti, Jagadish S., Kanellis, John, Laurence, Jerome M., Lim, Wai H., McTaggart, Steven J., O’Connell, Philip J., Pilmore, Helen L., Wong, Germaine, and Chadban, Steven J.

Published
2022
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38. Venovenous bypass in adult liver transplant recipients: A single-center observational case series.

Author

Weinberg, Laurence, Caragata, Rebecca, Hazard, Riley, Ludski, Jarryd, Lee, Dong-Kyu, Slifirski, Hugh, Nugraha, Patrick, Do, Daniel, Zhang, Wendell, Nicolae, Robert, Kaldas, Peter, Fink, Michael A., and Perini, Marcos V.

Subjects
*LIVER transplantation, *KIDNEYS, *LIVER, *ACUTE kidney failure, *LENGTH of stay in hospitals, *INTENSIVE care units, *ADULTS, *ERYTHROCYTES, *BILE
Abstract

Background: Very little information is currently available on the use and outcomes of venovenous bypass (VVB) in liver transplantation (LT) in adults in Australia. In this study, we explored the indications, intraoperative course, and postoperative outcomes of patients who underwent VVB in a high-volume LT unit. Methods: The study was a single-center, retrospective observational case series of adult patients who underwent VVB during LT at Austin Health in Melbourne, Australia between March 2008 and March 2022. Information on baseline preoperative status and intraoperative variables, including specific VVB characteristics as well as postoperative and VVB-related complications was collected. The lengths of intensive care unit and hospital stays as well as intraoperative and in-hospital mortality were recorded. Results: Of the 900 LTs performed at this center during the aforementioned 14-year period, 27 (3%) included a VVB procedure. VVB was performed electively in 16 of these 27 patients (59.3%) and as a rescue technique to control massive bleeding in the other 11 (40.1%). The median (interquartile range [IQR]) age of those who underwent VVB procedures was 48 (39–55) years; the median age was 56 (47–62) years in the non-VVB group (p<0.0001). The median model for end-stage liver disease (MELD) scores were similar between the two patient groups. Complete blood data was available for 622 non-VVB patients. Twenty-six VVB (96.3%) and 603 non-VVB (96.9%) patients required intraoperative blood transfusions. The median (IQR) number of units of packed red blood cells transfused was 7 (4.8–12.5) units in the VVB group compared to 3.0 units (1.0–6.0) in the non-VVB group (p<0.0001). Inpatient mortality was 18.5% and 1.1% for the VVB and non-VVB groups, respectively (p<0.0001). There were no significant differences in length of hospital stay or incidence of acute kidney injury, primary graft dysfunction, or long-term graft failure between the two groups. Patients in the VVB group experienced a higher rate of postoperative non-anastomotic biliary stricture compared to patients in the non-VVB group (33% and 7.9%, respectively; p = 0.0003). Conclusions: VVB continues to play a vital role in LT. This case series highlights the heightened risk of major complications linked to VVB. However, the global transition to selective use of VVB underscores the urgent need for collaborative multi-center studies designed to address outstanding questions and parameters related to the safe implementation of this procedure. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Frequency of hyperoxaemia during and after major surgery

Author

Karalapillai, Dharshi, Weinberg, Laurence, Peyton, Philip J, Ellard, Louise, Hu, Raymond, Pearce, Brett, Tan, Chong, Story, David, O'Donnell, Mark, Hamilton, Patrick, Oughton, Chad, Galtieri, Jonathan, Wilson, Anthony, Eastwood, Glenn, Bellomo, Rinaldo, and Jones, Daryl

Published
2020

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