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Abstract Purpose The KRAS mutation is highly prevalent in NSCLC and is associated with poor efficacy of immunotherapy. Nevertheless, the impact of KRAS mutation, mutation subtypes, and co-mutations on the effectiveness of immunotherapy remains uncertain. This study aimed to assess the influence of the KRAS mutation on the effectiveness of immunotherapy in NSCLC, specifically examining different subtypes of KRAS mutations and co-mutations. Methods We performed an extensive search of multiple databases, covering the period from January 1, 2000, to December 5, 2023. A total of 24 articles met our inclusion criteria and were included in this study. A comparative analysis assessed the influence of different subgroups, including KRAS mutation, KRAS wild-type, KRAS G12C mutation, KRAS G12D mutation, and KRAS with co-mutations in NSCLC with immunotherapy. The study outcomes include HR, with corresponding 95% CI and P-values for OS and PFS using Review Manager 5.4 software for the meta-analysis. Result The KRAS mutation appears to have a more beneficial impact on OS (HR 0.54 [95% CI: 0.41–0.71]; P

Abstract Background The fat-to-muscle mass ratio (FMR), integrating the antagonistic effects of fat and muscle mass, has been suggested as a valuable indicator to assess cardiometabolic health independent of overall adiposity. However, the specific associations of total and regional FMR with cardiometabolic risk are poorly understood. We aimed to examine sex-specific associations of total and regional FMR with single and clustered cardiometabolic risk factors (CRFs). Methods 13,505 participants aged 20 years and above were included in the cross-sectional study. Fat mass and muscle mass were assessed using a bioelectrical impedance analysis device. FMR was estimated as fat mass divided by muscle mass in corresponding body parts (whole body, arm, leg, and trunk). Clustered CRFs was defined as the presence of two or more risk factors, including hypertension, elevated blood glucose, dyslipidemia, insulin resistance (IR), and hyperuricemia. IR was assessed by the triglyceride glucose (TyG) index. Multivariable logistic regression models were applied to explore the associations of FMR in the whole body and body parts with single and clustered CRFs. Results The odds ratios (ORs) increased significantly for all single and clustered CRFs with the per quartile increase of total and regional FMR in both sexes (P for trend

Abstract Worldwide, governments imposed non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic to contain the pandemic more effectively. We examined the effectiveness of individual NPIs in the United States during the first wave of the pandemic. Three types of analyses were performed. First, a prototypical Bayesian hierarchical model was employed to gauge the effectiveness of five NPIs and they are gathering restriction, restaurant capacity restriction, business closure, school closure, and stay-at-home order in the 42 states with over 100 deaths by the end of the wave. Second, we examined the effectiveness of the face mask mandate, the sixth and most controversial NPI by counterfactual modeling, which is a variant of the prototypical Bayesian hierarchical model allowing us to answer the question of what if the state had imposed the mandate or not. The third analysis used an advanced Bayesian hierarchical model to evaluate the effectiveness of all six NPIs in all 50 states and the District of Columbia, and thereby provide a full-scale estimation of the effectiveness of NPIs and the relative effectiveness of each NPI in the entire United States. Our results have enhanced the collective knowledge on the general effectiveness of NPIs in arresting the spread of COVID-19.

Abstract Accurate calculation of equivalent circuit parameters is a prerequisite for accurately calculating the large‐capacity synchronous condenser parameter model. Due to its special transient operating conditions, the high transient magnetic saturation effect during operation causes the non‐linearity and time‐varying of the equivalent circuit parameters. The field mutual leakage reactance is the critical factor affecting the field current, and the time‐varying of the equivalent circuit parameters is closely related to the field current. However, the existing equivalent circuit parameter calculation methods considering field leakage reactance cannot achieve time‐varying parameters. A calculation method of time‐varying equivalent circuit parameters based on a back propagation neural network algorithm is proposed, which solves the calculation problem of time‐varying equivalent circuit parameters considering field mutual leakage reactance. Then, a 300MVar condenser is taken as the research object, and the proposed method is used to simulate the different operating conditions of the condenser and verified by the finite element method and experiment. The results show that the method improves the calculation accuracy of the equivalent circuit parameter model, reduces the calculation time, and applies to different operating conditions.

Objectives Diabetes is closely associated with risk of stroke and its adverse sequelae. Approximately 20%–33% of patients with stroke have diabetes. In China, however, it is unclear how stroke affects healthcare utilisation, medications and complications among people with diabetes. This study aimed to analyse the clinical characteristics, treatment options, medical expenses and complications of hospital outpatient healthcare associated with stroke in patients with diabetes in China.Design A retrospective, multicentre, observational study.Setting Beijing Municipal Medical Insurance Database, with data from 2016 to 2018.Participants The study included patients with diabetes whose data included 2016–2018 outpatient medication records and who had Beijing medical insurance. Patients who did not have continuous prescription records for more than 2 months were excluded from the analysis. In total, 2 853 036 people with diabetes were included, and patients who had and did not have a stroke were compared.Results In our study, 19.75%–22.30% of patients with diabetes suffered from stroke between 2016 and 2018. The average annual medical cost for a patient diagnosed with diabetes is ¥9606.65, and the cost increases to ¥13 428.39 when diabetes was combined with stroke; thus, stroke increases the medical cost for patients with diabetes by 39.78% (p

ObjectiveTo investigate the prevalence of chronic disease comorbidity among the elderly population in Jiangsu province to provide evidence for the development of chronic disease management strategies. MethodsA face-to-face survey was conducted among 21 344 residents aged ≥ 65 years recruited using stratified multistage cluster sampling from June to December 2021 in 12 districts/counties of six prefectures in Jiangsu province. A self-designed questionnaire and a brief cognitive impairment rating scale (Cog-12) developed by Chinese researchers were used in the survey. We analyzed the prevalence, prevalent types, and association rules of chronic comorbidity in the province's elderly population. ResultsOf the 20 724 participants with valid responses, 9 759 (47.1%) were identified as having a chronic comorbidity. Of the observed cases of comorbidity, 3 947 (40.4%), 2 731 (28.0%), and 3 081 (31.6%) had two, three, and four or more chronic conditions, respectively. The top three binary chronic disease comorbidity patterns were hypertension combined with cognitive impairment (19.69%), arthritis (16.57%), and cerebrovascular disease (12.20%). In addition, the top three chronic disease comorbidity patterns were hypertension combined with arthritis and cognitive impairment (8.05%), cerebrovascular disease and cognitive impairment (6.48%), and heart disease and cognitive impairment (5.63%). The analysis of comorbidity association rules yielded 325 strong association rules (53 binary comorbidity association rules, 137 ternary comorbidity association rules, and 135 quaternary comorbidity association rules). Among these, heart disease was strongly associated with cerebrovascular disease, renal insufficiency, chronic lung disease, and hypertension. Cerebrovascular disease was strongly associated with renal insufficiency, cognitive impairment, and hypertension. Renal insufficiency was strongly associated with diabetes, arthritis, and hypertension. Chronic pulmonary disease was strongly associated with cognitive impairment and cerebrovascular disease. ConclusionThe prevalence of chronic comorbidity among the elderly in Jiangsu province is high. Hypertension combined with arthritis, cerebrovascular disease, and cognitive dysfunction are the most common comorbidity patterns among the elderly in this region.

The frequent operation of the switching devices inside the converter valve (mainly composed of thyristors) and other equipment in the converter station of ultra-high voltage direct current (UHVDC) transmission system generates a large number of high harmonics and high-frequency interference, which is the main source of error of the DC electronic current transformers (ECT). In order to better understand the transfer characteristics of DC ECT, this paper considers the effects of temperature and frequency on the shunt and low-pass filter at the same time, and combines the field test at different temperatures with different current frequencies, the results are compared and fitted to obtain the broadband model of the transformer taking into account the temperature. Based on this model, the mechanism and degree of influence of different equipment parameters on the broadband transfer characteristics of the transformer are further analyzed by setting different analog circuit parameters and digital sampling frequencies. The results show that different temperatures, shunt radius, shunt residual inductance, low-pass filter cut-off frequency, sampling frequency of the combined unit affect the broadband transfer characteristics of the transformer, and when a certain threshold is reached, the accuracy of the transformer does not meet the current standard requirements, which should be taken into account during the analysis process, and the results have a reference value for the parameter selection of the transformer.

Optical wireless video transmission technology combines the advantages of high data rates, enhanced security, large bandwidth capacity, and strong anti-interference capabilities inherent in optical communication, establishing it as a pivotal technology in contemporary data transmission networks. However, video data comprises a large volume of image information, resulting in substantial data flow with significant redundant bits. To address this, we propose an adaptive block sampling compressive sensing algorithm that overcomes the limitations of sampling inflexibility in traditional compressive sensing, which often leads to either redundant or insufficient local sampling. This method significantly reduces the presence of redundant bits in video images. First, the sampling mechanism of the block-based compressive sensing algorithm was optimized. Subsequently, a wireless optical video transmission experimental system was developed using a Field-Programmable Gate Array chip. Finally, experiments were conducted to evaluate the transmission of video optical signals. The results demonstrate that the proposed algorithm improves the peak signal-to-noise ratio by over 3 dB compared to other algorithms, with an enhancement exceeding 1.5 dB even in field tests, thereby significantly optimizing video transmission quality. This research contributes essential technical insights for the enhancement of wireless optical video transmission performance.

A fluorescent probe based on ternary AgFeS2 quantum dots has been prepared for the design of ternary chalcogenides. The nanoparticles are synthesized with oleylamine as a stabilizer at a low temperature (particle size in the range of 2 to 3 nm) and they exhibit an intense blue emission in aqueous media. As for their internal structure, each nanoparticle’s relative stoichiometric ratio (AgFe1.01S1.91) is very close to the theoretical value of 1:1:2. Their magnetic properties have been studied with a vibrating sample magnetometer and they have ferromagnetism between 4 K and 298 K (applied magnetic field ranging between −10,000 and 10,000 Oe). In the presence of iodide ions, the emission at 458 nm derived from AgFeS2 QDs has been observed to give rise to fluorescence quenching. The detection system is based on a static quenching process and morphological change between iodide ions and AgFeS2, which has a good linear range from 0 to 37.5 μmol/L, with a limit of detection of 0.99 μM. The nanoprobe responds within 30 s for the efficient detection of iodide. Such functional quantum dots will provide a powerful indicator in environmental and bio-sensing applications.

As environmental and human changes combine, water shortage and ecological fragility are becoming increasingly serious issues in the basin. The national “14th Five-Year Plan” proposes to build resilient basins to enhance disaster resilience. On the basis of clarifying the multi-link characteristics of water resources system resilience under the influence of meteorology-hydrology-ecology-society-economy, this paper reveals the interrelationship and chain reaction among the factors affecting the resilience of water resources system by clarifying the multi-link characteristics of water resources system resilience. Based on the interconnections among meteorology-hydrology-engineering-economic society-ecology in regional water resources systems, this study constructs a resilience evaluation index for the water resources system. The index considers different objectives, dimensions, and scales to provide a comprehensive assessment of the system’s resilience. Based on the multi-dimensional relationship of the evaluation index system, the TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) method based on entropy weight method is employed to depict the resilience level of the water resources system at varying spatial and temporal scales. By focusing on Shanxi Province as the research subject, a multi-link evaluation framework for assessing the resilience of the water resources system is established, and a quantitative approach to evaluate its resilience is investigated. The results show that the level of water resources resilience in Shanxi Province has improved from 2017 to 2021, and there are certain spatial and temporal differences. In 2021, only Lvliang City and Yangquan City have low resilience level, and the resilience level of other cities has been improved. Among them, Taiyuan City has the highest resilience level of 0.56, which belongs to the high resilience level. The research results can improve the cognitive level of multi-link evolution mechanism of resilience to a certain extent, and provide scientific basis for multi-dimensional targeted regulation of water resources system resilience.

Abstract Based on quantum illumination (QI) protocol, microwave quantum radar has been developed, which has attracted great interest from radar researchers. While, according to the QI protocol, the quantum advantage of QI radar is related to the power of generated signal, which may lead to a trade‐off between its quantum advantage and the maximum detection range. However, the maximum detection range is an important indicator to measure the performance of the radar. Therefore, it is necessary to quantitatively analyse the maximum detection range and quantum advantages of microwave QI radar, which will help us understand its performance from the perspective of radar applications and further evaluate the potential application scenarios and future research directions of it. The microwave quantum radar equation is developed, by the authors, based on the classical radar equation with the consideration of the quantum properties of extremely weak signals. Then, the maximum detection range of QI radar and classical two mode noise radar in different microwave bands is comprehensively compared and analysed. The possible applications of microwave QI radars in different bands are also discussed. In addition, the authors demonstrate that the symmetrical quantum limited amplification actually has no contribution to improving the detection range of a QI radar.

In light of the ‘double reduction’ policy, which affords adolescents increased time for extracurricular pursuits, the strategic organization of these activities’ form and content is imperative. Prior research has established a robust correlation between adolescent participation in extracurricular arts and sports and the enhancement in their social and emotional skills. Nevertheless, the relationship between extracurricular arts and sports activities and the various dimensions of social and emotional skills, as well as the connection between participation in different types of these activities and the enhancement in social and emotional skills, requires further investigation. Utilizing the Theory of Multiple Intelligence and data from the OECD-SSES2019 Suzhou (China) student survey, this study employs Ordinary Least Squares (OLS) and coarsened exact matching (CEM) methodologies to address these gaps. In China, participation in extracurricular arts and sports activities is significantly positively associated with various dimensions of social and emotional skills, with a synergistic effect observed between these activities in enhancing these skills. Additionally, this study finds age-related heterogeneity in the relationship between participation in extracurricular arts and sports activities and the improvement in social and emotional skills.

Abstract Background and aims To assess the cost-effectiveness of utilizing IDegLira in comparison to other treatment regimens ( liraglutide and degludec) in managing type 2 diabetes, taking into account the Chinese healthcare system’s perspective. Methods The clinical data were obtained from the randomized controlled trials (RCTs) of the DUAL I and DUAL II evidence studies that took place in China. To estimate the lifetime quality-adjusted life-years (QALYs) and direct medical costs of patients receiving different treatment strategies from a long-term perspective, the IQVIA CORE Diabetes Model version 9.0 (IQVIA, Basel, Switzerland) was utilized. The costs were evaluated from the perspective of the China National Health System. Future costs and clinical benefits were discounted annually at 5%, and sensitivity analyses were conducted. Results IDegLira was projected to reduce the incidence of diabetes-related complications and improve quality-adjusted life expectancy (QALE) versus liraglutide and degludec. A survival benefit was observed with IDegLira over Liraglutide (0.073 years). Lifetime costs were lower by Chinese yuan (CNY) 27,945 on IDegLira than on Liraglutide therapy. A similar survival benefit was observed with IDegLira over degludec (0.068 years). Lifetime costs were lower by CNY 1196 on IDegLira than on degludec therapy. Therefore, IDegLira was found to be cost-effective versus liraglutide and degludec with incremental cost-effectiveness ratios of Dominant per QALY gained, respectively, under the threshold of three times the gross domestic product (GDP) per capita in China. Conclusion IDegLira is a cost-effective hypoglycemic treatment option that delivers positive clinical outcomes while also reducing costs for Chinese patients living with type 2 diabetes.

Global climate issues are a serious impediment to green and sustainable urban development. The purpose of this study is to explore the influence of structural change on urbanization in terms of population, energy, industry, and economics while accounting for per capita carbon emissions. In this article, three income groups are defined using the World Bank database's income criteria, and panel data for 132 countries and three income groups is regressed using a panel threshold model from 1997 to 2021. The threshold variable in this framework is carbon emissions per capita, and the explained variable is urbanization; the explanatory factors are population structure (newborn birth rate), energy structure (renewable energy), industry structure (industrialization), and economic structure (GDP). The study's findings revealed that: (1) the newborn birth rate and renewable energy inhibit urbanization; however, the mediating effect of per capita carbon emissions mitigates this phenomenon. (2) The impact of industrialization on urban development has gradually become positive, mediated by per capita carbon emissions. (3) The mediating effect of per capita carbon emissions has increased economic growth's contribution to urbanization. (4) For high-, middle-, and low-income groups, there is some variability in the non-linear connection between the variables; in particular, the association between the newborn birth rate, renewable energy, and urbanization is more substantial. Finally, based on the study's findings, important policy suggestions in terms of structural determinants and heterogeneity are presented for policymakers all around the globe to use as a guide for implementing global urban-environmentally sustainable development plans.

Compared to conventional laser powder bed fusion (c-LPBF), micro laser powder bed fusion (μ-LPBF) offers enhanced capabilities for fabricating complex components with exceptional accuracy. This is achieved through the utilization of a finer laser beam and smaller metal powder, leading to distinct differences in microstructure when compared to c-LPBF. Despite promising outcomes, a comprehensive understanding of these distinctions remains incomplete. One notable observation in the μ-LPBF samples in this study was the presence of a weaker 〈100〉 texture along the build direction. Additionally, these samples exhibited smaller grain sizes, a higher density of low-angle grain boundaries, and the presence of geometrically necessary dislocations. Significantly, μ-LPBF demonstrates the potential to produce IN718 with exceptional isotropic mechanical properties, primarily attributed to its capacity to generate refined microstructures and facilitate distinct solidification behaviors. Of particular significance was the remarkable 39.1 % increase in yield strength observed along the building direction by μ-LPBF. Furthermore, the differences in yield strength and ultimate tensile strength between various directions are notably reduced to 7 and 41 MPa, respectively, with a minimal total elongation variation of only 1.8 %. To gain deeper insights into the solidification behavior, Computational fluid dynamics were conducted in conjunction with the discrete element method.

To improve the utilization of soluble dietary fiber (SDF) from tiger nut residues, the response surface methodology was used to optimize the conditions of superfine grinding to produce SDF with antioxidant and metal-ion-binding properties. The yield was increased (30.56%) and the average particle diameter of SDF was decreased (D50: 32.80 μm) under the optimal conditions (a proportion of grinding medium of 100%, a feeding mass of 0.90 kg, a grinding time of 20 min, and a moisture content of 8.00%). In addition, superfine grinding substantially modified the surface morphology and increased the SDF content and the proportion of monosaccharides by decreasing the molecular weight. Moreover, superfine grinding remarkably enhanced the in vitro antioxidant activities (ABTS+, DPPḤ, and ·OH) of the SDF, which also exhibited favorable metal-ion-binding properties (Ca2+, Zn2+, and Co2+). These results suggest that superfine grinding can be used as a technique to modify dietary fiber to manufacture functional SDF.

The early inter-turn short-circuit fault of field winding (ISFF) occurs between adjacent strands in a single rotor slot, which is a significant safety hazard in the transient operation of the large-capacity synchronous condenser. To realize high-precision detection of early ISFF, this paper proposes a characteristics analysis method of ISFF with the field strand as the minimum unit. This method combines the novel stator winding asymmetric branch connection mode of the condenser. Compared with the fault characteristics analysis method with the field coil as the minimum unit, the proposed method can analyze ISFF characteristics between strands in a single rotor slot and has higher fault detection resolution, which is especially suitable for electric excitation synchronous generators with stator winding asymmetric branch connections. The results show that ISFF occurs in a single rotor slot, the even harmonics components appear in the field magnetomotive force and partial stator winding asymmetric branch current, and the 2nd harmonic component accounts for the largest proportion. Taking the 5 turns ISFF in slot 1 of the 2-pole 3-branch condenser as an example, the 2nd harmonic in the field magnetomotive force even harmonics accounts for 55.15%, and the number of branches with even harmonics components current accounts for 66.67% of the total number of branches. The research results can provide theoretical support for high-precision ISFF detection to avoid fault expansion.

Abstract Background As a cardiometabolic disease, hypertension has shown an obvious upward trend, becoming a global epidemic chronic disease. Lifestyle intervention is a fundamental method for lowering blood pressure. This systematic review and meta-analysis aimed to evaluate the effects of time-restricted eating (TRE) on blood pressure. Methods Studies were retrieved from the PubMed, Embase, Cochrane Library, and Web of Science databases to evaluate the effects of TRE on blood pressure. The time frame of search was from the start of database construction until July 14, 2022.There were no language restrictions. Meta-analysis and meta-regression were performed using Stata version 16. The weighted mean difference with 95% CI was used to assess the effect of TRE on blood pressure, heart rate, weight, blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides. The main ending of this article were blood pressure and heart rate, while the secondary ending were weight, blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides. Results Ten randomized controlled trials involving 694 patients were identified. TRE significantly reduced systolic blood pressure (SBP) (mean difference = −4.15; 95% CI: −6.73, −2.30; P < 0.0001), but had no significant effect on diastolic blood pressure (DBP) (mean difference = −2.06; 95% CI: −4.16, 0.02; P = 0.053) and no beneficial effect on heart rate (mean difference = 0.36; 95% CI: −2.83, 3.54; P = 0.0825). TRE promoted weight loss (mean difference = −1.63; 95% CI: −2.61, −0.64; P = 0.001) and decreased blood glucose levels (mean difference = −2.80; 95% CI: −4.64, −0.96; P = 0.003), but had no significant effect on total cholesterol (mean difference = 0.03, 95% CI: −10.01, 10.08; P = 0.995), HDL-C (mean difference = 0.85, 95% CI: −1.80, 3.49; P = 0.531), LDL-C (mean difference = −0.86, 95% CI: −6.47, 4.76; P = 0.764), or triglycerides (mean difference = −3.524, 95% CI: −9.49, 2.45; P = 0.248). In a separate meta-regression analysis, the degree of SBP change was related to weight loss (P = 0.044) but not to glucose improvement (P = 0.867). Conclusions The present meta-analysis suggests that TRE significantly reduced SBP, while no effect of reducing DBP was seen. The observed lower blood pressure may be attributed to significant weight loss. The effects of TRE on heart rate and blood lipid levels were not apparent.

Sand production significantly influences the safety and stability of gas hydrate exploitation in reservoirs with high mud content. Gravel packing is an effective method for sand control. The median grain size ratio (D50/d50) values and fine particle content of gravel pack are important factors in sand control during natural gas hydrate exploitation. This paper focuses on the sand blocking effect and permeability characteristics of different grades of gravel. The sand retention test was carried out on four samples with different ratios. The optimal D50/d50value and fine particle content for gas hydrate production were obtained. A laser particle size analyzer and geotechnical test found the reservoir and gravel layer pore structure change. The results show that the optimal GSR was 24.5, and the optimal fine particle content was about 38%. The permeability decline of the gravel layer occurs in the early stage of production, and the fine particles in the gravel will slow down the degree of seepage damage. For gravel with the same particle size range and different median particle sizes, it has little effect on sand control accuracy but mainly on permeability. The research in this paper can provide a reference for selecting sand control gravel for natural gas exploitation in marine areas.

Background and AimsNeedle injection and needle-free injection were proven effective in improving glycated hemoglobin (HbA1c) in type 2 diabetes mellitus (T2DM) patients. However, it is unclear if needle-free and needle injections of insulin during intensive insulin therapy in hospitalized patients provide similar efficacy and safety benefits.MethodsA self-controlled cross-over study was conducted on 62 patients with T2DM who received intensive long-acting and short-acting insulin injections with or without needles. The 7-point blood glucose test was performed on the 6th day after insulin administration and the injection method switched on the 7th day of hospitalization. The difference was compared in 7-point blood glucose levels.ResultsThe blood glucose levels at fasting (mean difference=-1.09 ± 2.38mmol/L, 95% CI, -1.69 to -0.48, p=0.0007) and post-breakfast (-1.14 ± 3.02mmol/L, 95%CI, -1.91 to -0.37, p=0.004) were better when patients were receiving needle-free injections compared to when receiving a needle injection. Indeed, daily blood glucose fluctuation, which presented as the area under the curve of glycemia, was decreased in needle-free injection periods (-0.3.48 ± 9.64, 95%CI, -5.95 to -1.01, p=0.0065). There was no significant difference in the dose of long-acting insulin between the two injection methods (-0.32 ± 2.69, 95%CI, -0.99 to 0.37, p>0.05). The dose of fast-acting insulin during the needle-free period was lower than that of when patients received needle injections (-1.66 ± 6.45, 95%CI, -3.29 to -0.025, p

In order to explore the structural characterization and anti-digestion characteristics of mung bean resistant dextrin, mung bean starch was used as raw material to prepare mung bean resistant dextrin by acid heat method. Its surface morphology, crystal form, polarized light, functional groups and glycosidic bonds were characterized, and its anti-digestion characteristics were explored by simulating in vitro digestion. The results showed that compared with mung bean starch, the structure of mung bean resistant dextrin was fragmented with different sizes and irregular shapes. The polarized light cross disappeared, and the chemical groups were similar. The peak positions of each functional group remained unchanged and no new peaks were generated. The crystal structure was amorphous, and the molecular weight MW of molecular degradation was 5.24×103 g/mol. The glycosidic bond was broken and a new digestion-resistant glycosidic bond was generated. The simulated in vitro digestion experiment showed that mung bean resistant dextrin had strong anti-digestion ability, and the anti-digestion content was 92.28%. This experiment aims to provide theoretical and data support for the development of functional dietary fiber.

ObjectiveDiabetic peripheral neuropathy (DPN) causes significant illness in patients and has a negative impact on the economy. The objective of this study is to evaluate the cost and quantity of anti-diabetic drugs needed by patients with or without DPN, as well as their variation trends in Beijing between 2016 and 2018.MethodsThis observational cross-sectional study used data on diabetic patients with outpatient medication records obtained from Beijing Medical Insurance from 2016 to 2018. The medications, comorbidities, diabetes-related complications, treatment strategies, and costs of drug treatment were compared between DPN patients and non-DPN patients.ResultsOf the 28,53,036 diabetic patients included in the study, 3,75,216 (13.15%) had DPN and 1,87,710 (50.03%) of the DPN patients were women. Compared with non-DPN patients, DPN patients used more mediations (4.7 ± 2.47 vs. 3.77 ± 2.32, p < 0.0001, in 2018) to treat related complications and comorbidities (2.03 ± 1.2 vs. 1.71 ± 1.05; 2.68 ± 1.93 vs. 2.06 ± 1.86, p < 0.0001, respectively, in 2018). The total annual costs of drug treatment were higher in DPN patients than in non-DPN patients (¥12583.25 ± 10671.48 vs. ¥9810.91 ± 9234.14, p < 0.0001, in 2018). The usage of DDP4i increased from 2.55 to 6.63% in non-DPN patients and from 4.45 to 10.09% in DPN patients from 2017 to 2018.ConclusionsThe number of comorbidities, diabetic complications, medications, and annual drug treatment costs were greater in DPN patients than in non-DPN patients.

In this study, manganized soluble dietary fiber (SDF–Mn(II)) was prepared from tigernut meal using a microwave solid-phase synthesis method with SDF. Microscopic morphological and structural analyses of SDF–Mn(II) were carried out using scanning electron microscopy, Fourier infrared spectroscopy, UV full-band scanning, X-ray diffraction, a thermal analyzer, gel permeation chromatography, and nuclear magnetic resonance, and its in vitro hypoglycemic activity was initially investigated. The results of these analyses revealed that the reaction of Mn(II) with SDF mainly involved hydroxyl and carbonyl groups, with the Nuclear magnetic resonance (NMR) analysis showing that specific covalent binding was produced and substitution was mainly carried out at the C6 position. Moreover, compared with SDF, the SDF–Mn(II) complex exhibited a porous structure, red-shifted, and color-enhancing effects on the UV characteristic peaks, significantly increased crystallinity and decreased molecular weight, and improved thermal stability; in addition, SDF–Mn(II) afforded significantly enhanced inhibition of α-amylase and α-glucosidase and possesses good in vitro digestive enzyme inhibition activity.

Fault diagnosis of rotating machinery plays an important role in modern industrial machines. In this paper, a modified sparse Bayesian classification model (i.e., Standard_SBC) is utilized to construct the fault diagnosis system of rotating machinery. The features are extracted and adopted as the input of the SBC-based fault diagnosis system, and the kernel neighborhood preserving embedding (KNPE) is proposed to fuse the features. The effectiveness of the fault diagnosis system of rotating machinery based on KNPE and Standard_SBC is validated by utilizing two case studies: rolling bearing fault diagnosis and rotating shaft fault diagnosis. Experimental results show that base on the proposed KNPE, the feature fusion method shows superior performance. The accuracy of case1 and case2 is improved from 93.96% to 99.92% and 98.67% to 99.64%, respectively. To further prove the superiority of the KNPE feature fusion method, the kernel principal component analysis (KPCA) and relevance vector machine (RVM) are utilized, respectively. This study lays the foundation for the feature fusion and fault diagnosis of rotating machinery.

This study unravels an important daytime Cl2 source in the extra-polar atmosphere and shows that photolysis of particle nitrate at high acidity produced unprecedented levels of Cl2, boosting the oxidative power and air pollutants like O3.

According to the Olympic Charter, the construction of new permanent venues or infrastructure for the purposes of the organization of the Olympics shall only be considered on the basis of sustainable legacy plans. However, as time passes, the Olympic legacies grow increasingly unsustainable and create conflicts between humans and nature. This perspective examined the spatial distribution of the Beijing 2022 Winter Olympics venue legacy. We presented a spatial assessment of Olympic venues’ legacy experience in terms of construction and sustainability. The findings indicate that the Beijing 2022 Winter Olympics venues incorporated sustainable land management and green ecology concepts from the Olympic Movement, and that the legacy could serve as an example for future development of Olympic infrastructure, natural sites, and resource management.

Bladder cancer is the most common malignant tumor of the urinary system, however there are several shortcomings in current diagnostic and therapeutic measures. In terms of diagnosis, the diagnostic tools currently available are not sufficiently sensitive and specific, and imaging is poor, leading to misdiagnosis and missed diagnoses, which can delay treatment. In terms of treatment, current treatment options include surgery, chemotherapy, immunotherapy, gene therapy, and other emerging treatments, as well as combination therapies. However, the main reasons for poor efficacy and side effects during treatment are the lack of specificity and targeting, improper dose control of drugs and photosensitizers, damage to normal cells while attacking cancer cells, and difficulty in delivering siRNA to cancer cells. Nanomedicine is an emerging approach. Among the many nanotechnologies applied in the medical field, nanocarrier-assisted drug delivery systems have attracted extensive research interest due to their great translational value. Well-designed nanoparticles can deliver agents or drugs to specific cell types within target organs through active targeting or passive targeting (enhanced permeability and retention), which allows for imaging, diagnosis, as well as treatment of cancer. This paper reviews advances in the application of various nanocarriers and their advantages and drawbacks, with a focus on their use in the diagnosis and treatment of bladder cancer.

Using molecular dynamics simulations, we investigate shock-induced sliding of a set of (0 0 1) twist grain boundaries (GBs) in Cu bicrystal, with shock direction parallel to GB and low shock strength. The GB sliding is produced via transverse particle motion in constituent grains and resisted by GB viscosity. Its utmost magnitude su increases first and then decreases with increasing of the angle between [1 0 0] direction in grain and shock direction. Quantitative acoustic wave equation analysis reveals that transverse particle motion exists because of the anisotropic elastic stiffness and particular grain orientation. For GBs of noteworthy sliding, boundary viscosity η is estimated according to the deceleration of volume element in grain, and decreases piecewisely with increasing misorientation angle. su is jointly determined by η and transverse particle velocity dependent on grain orientation.

Abstract Noise‐shaping (NS) successive approximation register (SAR) analogue‐to‐digital converters (ADCs) are an attractive architecture for power and area efficiency in moderate resolution and bandwidth applications. NS SAR ADCs employing a passive integrator are good candidates for their omission of power‐hungry and scaling‐unfriendly amplifiers. However, existing passive NS SAR ADCs have a very limited degree of freedom in realising their noise transfer function (NTF), resulting in poor in‐band noise suppression. In this letter, a passive switched‐capacitor 2nd‐order NS SAR ADC that is the first of its kind to offer controllable complex poles to optimise the NTF is proposed. This is achieved by eliminating a capacitor charge clearing operation in a conventional 1st‐order NS SAR. The proposed NS SAR ADC also offers simple circuits insensitive to process–voltage–temperature (PVT) variations, and small area with only two extra clock phases. Transistor‐level circuit simulation of a 7‐bit, 8‐MHz bandwidth, 128 MS/s prototype in a 65‐nm CMOS shows a 70 dB signal to noise and distortion ratio (SNDR), an improvement of 19 dB compared to that of a regular 7‐bit SAR ADC.

Keloid is a common benign skin tumor in the outpatient department, and patients are often accompanied by itching and pain. Since the pathogenesis is unknown, the effect of single method treatment is unsatisfactory, and therefore the recurrence rate is high. Therefore, comprehensive treatment is mostly used in clinical treatment. Adjuvant radiotherapy is currently one of the most effective treatments for keloid. After long-term clinical practice, brachytherapy and electron beam radiotherapy has increasingly become the gold standard of treatment, because brachytherapy provides more focused radiation treatment to focal tissue to significantly reduce recurrence rate, and better preserve normal tissue. With the development of new radiotherapy techniques, more options for the treatment of keloid. Currently, adjuvant radiotherapy has been widely recognized, but there is no consensus on the optimal protocol for adjuvant radiotherapy for keloids. This review provides a review of published treatment options and new radiotherapy techniques for adjuvant radiotherapy of keloids and gives a comprehensive evaluation for clinical treatment.

Prostate cancer (PCa) is the most common new cancer case and the second most fatal malignancy in men. Surgery, endocrine therapy, radiotherapy and chemotherapy are the main clinical treatment options for PCa. However, most prostate cancers can develop into castration-resistant prostate cancer (CRPC), and due to the invasiveness of prostate cancer cells, they become resistant to different treatments and activate tumor-promoting signaling pathways, thereby inducing chemoresistance, radioresistance, ADT resistance, and immune resistance. Nanotechnology, which can combine treatment with diagnostic imaging tools, is emerging as a promising treatment modality in prostate cancer therapy. Nanoparticles can not only promote their accumulation at the pathological site through passive targeting techniques for enhanced permeability and retention (EPR), but also provide additional advantages for active targeting using different ligands. This property results in a reduced drug dose to achieve the desired effect, a longer duration of action within the tumor and fewer side effects on healthy tissues. In addition, nanotechnology can create good synergy with radiotherapy, chemotherapy, thermotherapy, photodynamic therapy and gene therapy to enhance their therapeutic effects with greater scope, and reduce the resistance of prostate cancer. In this article, we intend to review and discuss the latest technologies regarding the use of nanomaterials as therapeutic and diagnostic tools for prostate cancer.

Inflammatory activation and intestinal flora imbalance play key roles in the development and progression of inflammatory bowel disease (IBD). Soluble dietary fiber (SDF) and selenium have been proven to be effective for preventing and relieving IBD. This study investigated and compared the therapeutic efficacy of millet-derived selenylated-soluble dietary fiber (Se-SDF) against dextran sulfate sodium (DSS)-induced colitis in mice alone or through the synergistic interaction between selenium and SDF. In female mice, Se-SDF markedly alleviated body weight loss, decreased colon length, reduced histological damage scores, and enhanced IL-10 expression to maintain the barrier function of intestinal mucosa compared to male mice. The 16S rRNA sequence analysis further indicated that pretreatment with Se-SDF restored the gut microbiota composition in female mice by increasing the relative abundance of Lactobacillus and the Firmicutes/Bacteroidetes ratio. In conclusion, these findings demonstrated that Se-SDF can protect against DSS-induced colitis in female mice by regulating inflammation and maintaining gut microbiota balance. This study, therefore, provides new insights into the development of Se-SDF as a supplement for the prevention and treatment of colitis.

In this paper, an atmospheric structure constant Cn2 model is proposed for evaluating the channel turbulence degree of atmospheric laser communication. First, we derive a mathematical model for the correlation between the atmospheric coherence length r0, the isoplanatic angle θ0 and Cn2 using the Hufnagel–Valley (HV) turbulence model. Then, we calculate the seven parameters of the HV model with the actual measured r0 and θ0 data as input quantities, so as to draw the Cn2 profile and the θ0 profile. The experimental results show that the fitted average Cn2 contours and single-day Cn2 contours have superior fitting performance compared with our historical data, and the daily correlation coefficient between the single-day computed θ0 contours and the measured θ0 contours is up to 87%. This result verifies the feasibility of the proposed method. The results validate the feasibility of the proposed method and provide a new technical tool for the inversion of turbulence Cn2 profiles.

AimsThe cost of drug regimens prescribed to Chinese patients has not been evaluated. This study aims to evaluate the medical costs and hypoglycemic agents for diabetes mellitus patients with or without chronic respiratory disease in Beijing, and to investigate the changes in the costs and number of antidiabetic medications used for diabetes patients with chronic respiratory disease from 2016 to 2018.MethodsThis observational, retrospective study included diabetes patients with outpatient medication records from Beijing Medical Insurance between 2016 and 2018. The medications, including hypoglycemic and nonhypoglycemic drugs, insulin dosage, comorbidities, diabetes-related complications, treatment strategies, and annual medical costs, were recorded.ResultsThis study included 2,853,036 diabetes patients from 2016 to 2018. About 18.95%–20.53% of patients with chronic respiratory disease were predominantly distributed among those aged 45–84 years (88.7%–89.1%). Diabetes patients with chronic respiratory disease used more medications (4.48 ± 2.41 vs. 3.76 ± 2.33) and had higher total annual drug costs (¥12,286 ± 10,385 vs. ¥9700 ± 9202) to treat more comorbidities (2.52 ± 1.53 vs. 2.05 ± 1.85) than those without chronic respiratory disease (p

With the development of the social economy and the continuous growth of the population, emergencies within field stations are becoming more frequent. To improve the efficiency of emergency evacuation of field stations and further protect people’s lives, this paper proposes a method based on improved YOLOv5s target detection and Anylogic emergency evacuation simulation. This method applies the YOLOv5s target detection network to the emergency evacuation problem for the first time, using the stronger detection capability of YOLOv5s to solve the problem of unstable data collection under unexpected conditions. This paper first uses YOLOv5s, which incorporates the SE attention mechanism, to detect pedestrians inside the site. Considering the height of the camera and the inability to capture the whole body of the pedestrian when the site is crowded, this paper adopts the detection of the pedestrian’s head to determine the specific location of the pedestrian inside the site. To ensure that the evacuation task is completed in the shortest possible time, Anylogic adopts the principle of closest distance evacuation, so that each pedestrian can leave through the exit closest to him or her. The experimental results show that the average accuracy of the YOLOv5s target detection model incorporating the SE attention mechanism can reach 94.01%; the constructed Anylogic emergency evacuation model can quickly provide an evacuation plan to guide pedestrians to leave from the nearest exit in an emergency, effectively verifying the feasibility of the method. The method can be extended and applied to research related to the construction of emergency evacuation aid decision-making systems in field stations.

In recent years, the hairpin winding flat wire motor has received more and more attention because of its high power density and high torque, but the problem of increased AC copper loss caused by the increase of its wire diameter has restricted the use of the motor. Aiming at the problem of large AC copper loss in hairpin winding flat wire motors, this paper introduces the use of formed transposition windings into permanent magnet synchronous motors. Through analysis and comparison, the transposition bar suitable for permanent magnet synchronous motor is determined, and a method of inter-turn transposition that can improve the slot full rate of the motor is proposed. Taking a 223kW permanent magnet synchronous motor as an example, the transient field of the stator bar under 360° transposition was calculated by using the field-circuit combined three-dimensional(3-D) finite element method. By calculating the data, combined with the AC copper loss calculation method of the formed transposition winding given in the article, the distribution of the DC copper loss, eddy current copper loss and circulating copper loss of the motor is obtained. Compared with hairpin windings, the use of formed transposition windings can reduce the AC copper loss of the motor to a certain extent, the feasibility of using the formed transposition winding in the permanent magnet synchronous motor is verified.

Abstract The development of ductal structures during branching morphogenesis relies on signals that specify ductal progenitors to set up a pattern for the ductal network. Here, we identify cellular asymmetries defined by the F-actin cytoskeleton and the cell adhesion protein ZO-1 as the earliest determinants of duct specification in the embryonic submandibular gland (SMG). Apical polarity protein aPKCζ is then recruited to the sites of asymmetry in a ZO-1-dependent manner and collaborates with ROCK signaling to set up apical-basal polarity of ductal progenitors and further define the path of duct specification. Moreover, the motor protein myosin IIB, a mediator of mechanical force transmission along actin filaments, becomes localized to vertices linking the apical domains of multiple ductal epithelial cells during the formation of ductal lumens and drives duct maturation. These studies identify cytoskeletal, junctional and polarity proteins as the early determinants of duct specification and the patterning of a ductal tree during branching morphogenesis of the SMG.

Permanent magnet synchronous motors with the formed winding can not only improve the slot fill factor and heat dissipation capacity but also effectively reduce the additional loss in the winding. Formed winding permanent magnet synchronous motors will become the future development tendency. Due to inherent features of the formed winding, the circulating current loss is a non-negligible issue. This paper proposes using the formed winding in permanent magnet synchronous motors and analyzes the circulating current loss in the formed winding. First, the finite element models of integer slot and fractional slot motors are established, and the magnetic field analysis are carried out. Then two commonly used methods of calculating circulating current loss are introduced in detail, and their calculation results are compared. Moreover, the high-precision field-circuit coupled finite element method is used to calculate the circulating current loss of integer and fractional motors. And circulating currents of the hairpin winding and the formed winding are compared. The analysis indicates that the circulating current in the formed winding cannot be ignored. Finally, comprehensive and in-depth research on the influencing factors of circulating current loss in the formed winding has been conducted. The results clarify that the number of parallel strands, the width of the slot opening, and the stator current have a considerable influence on the circulating current loss.

The effect of fermentation treatment on the surface morphology, crystal structure, molecular weight, chain length distribution, and physicochemical properties of corn starch was investigated using natural fermentation of corn ballast. The amylose content in corn ballast starch reduced at first after natural fermentation, then grew, following the same trend as solubility. There were certain erosion marks on the surfaces of fermented corn ballast starch granules. The crystalline structure of corn ballast starch remained the same, i.e., a typical A-type crystalline structure, at different fermentation times; however, the intensities of diffraction peaks were different. The weight-average molecular weight of starch first increased and then decreased after fermentation. The content of low-molecular-weight starch (peak 3) decreased from 25.59 to 24.7% and then increased to 25.76%, while the content of high-molecular-weight starch (peak 1) increased from 51.45 to 53.26%, and then decreased to 52.52%. The fermentation time showed a negative correlation with the viscosity of starch, and the pasting temperature first increased, and then decreased. Natural fermentation can be used as a technical means to produce corn starch products as a result of the experiments' findings, and future experiments will detect and analyze the bacterial structure of corn fermentation broth in order to better understand the molecular mechanism of natural fermentation affecting the structure and physicochemical properties of corn starch.

Abstract The objectives of this study were to analyze and compare the proteomic and peptide profiles of mung bean (Vigna radiata) seeds and sprouts. Label-free proteomics and peptidomics technologies allowed the identification and relative quantification of proteins and peptides. There were 1918 and 1955 proteins identified in mung bean seeds and sprouts, respectively. The most common biological process of proteins in these two samples was the metabolic process, followed by cellular process and single-organism process. Their dominant molecular functions were catalytic activity, binding, and structural molecule activity, and the majority of them were the cell, cell part, and organelle proteins. These proteins were primarily involved in metabolic pathways, biosynthesis of secondary metabolites, and ribosome. PCA and HCA results indicated the proteomic profile varied significantly during mung bean germination. A total of 260 differential proteins between mung bean seeds and sprouts were selected based on their relative abundance, which were associated with the specific metabolism during seed germination. There were 2364 peptides identified and 76 potential bioactive peptides screened based on the in silico analysis. Both the types and concentration of the peptides in mung bean sprouts were higher than those in seeds, and the content of bioactive peptides in mung bean sprouts was deduced to be higher.

Abstract Background The effects of whole grain diet on cardiovascular risks in obese and overweight adults is not well established. Our goal was to conduct a systematic review and meta-analysis on the effect of whole grain diet on cardiovascular risks in obese/overweight adults. Methods PubMed, Embase and Cochrane were systematically scanned for randomized controlled trials (RCTs), and studies were selected based on certain inclusion and exclusion criteria. The primary outcome was the effectiveness of whole grain food consumption in reducing body weight. The secondary outcomes were the effect of whole grain food consumption on cardiovascular disease (CVD) risk factors including plasma low-density lipoprotein cholesterol (LDL-C), insulin resistance index, blood pressure, body mass index (BMI), C-reactive protein (CRP), and waist circumference in obese/overweight adults. Results Our results showed that whole grain consumption was associated with lower body weight (mean difference (MD) = − 0.5, 95% confidence intervals (CI) [− 0.74, 0.25], I2 = 35%, P

ObjectiveThis systematic review and meta-analysis aimed to evaluate the effects of SGLT-2 inhibitors (SGLT-2i) on endothelial function and arteriosclerosis in diabetic patients.MethodsRandomized controlled trials (RCTs) were retrieved from PubMed, Embase, Cochrane Library, and Web of Science databases to evaluate the effects of SGLT-2i on endothelial function and atherosclerosis in type 2 diabetic patients.ResultsWe selected 9 RCTs and 2 cohort studys involving 868 patients. Of these, six studies provided flow-mediated dilation (FMD) levels before and after the intervention. The pooled analysis showed that SGLT-2i could significantly improve the FMD compared to the control group (SMD: 0.18, 95% CI: 0.02 ~ 0.34, P = 0.03). Three studies provided the change in FMD before and after the intervention. Pooled analysis showed no significant differences in FMD change between the SGLT-2i group and the control group. (MD: 2.1, 95%-CI: -0.11~4.31, P = 0.06). Five studies showed pulse wave velocity (PWV) results. Pooled analysis showed no significant differences in the change in PWV between the SGLT-2i group and the control group (SMD: 0.11, 95%-CI: − 0.15 ~ 0.37, P = 0.4).ConclusionsThe ability of SGLT-2 inhibitors to improve FMD was significant, but there was no significant effect on PWV levels. SGLT-2i was superior to other antidiabetic agents in improving arterial endothelial function.

Background. Exenatide is a glucagon-like peptide-1 receptor agonist that can reduce body weight. This study aimed to determine the efficacy of exenatide on body mass index (BMI) reduction in patients with type 2 diabetes mellitus (T2DM) with differing baseline body weight, blood glucose, and atherosclerotic status and to determine if there is a correlation between BMI reduction and cardiometabolic indices in these patients. Methods. This retrospective cohort study used data from our randomized controlled trial. A total of 27 T2DM patients treated with combination therapy of exenatide twice daily and metformin for 52 weeks were included. The primary endpoint was a change in the BMI from the baseline to week 52. The secondary endpoint was a correlation between BMI reduction and cardiometabolic indices. Findings. The BMIs of overweight and obesity patients and those with glycated hemoglobin (HbA1c) ≥ 9% significantly decreased −1.42 ± 1.48 kg/m2P=0.015 and −0.87 ± 0.93 kg/m2P=0.003, respectively, at the baseline after 52 weeks of treatment. There was no reduction in BMI in patients with normal weight, HbA1c

Studies have shown the indicative role of handgrip strength in health. However, there is limited evidence revealing its potential effect on death events among middle-aged and older adults in China. We aimed to prospectively evaluate if lower handgrip strength is associated with the event of death. Among 17,167 middle-aged and older adults between age 45 to 96, handgrip strength was collected by a handheld dynamometer in a Chinese longitudinal study of aging trend (CHARLS) 2011–2018. Using Cox proportional hazard models with exposures, we assessed the association between handgrip strength and death events. Elevated handgrip strength values were independently associated with the decreased death risk. These results illustrate that lower handgrip strength is an independent indicator of death risks among middle-aged and older Chinese, which highlights the significance of related intercessions. The median values of five levels of handgrip strength in the entire cohort were 16.5,23,28,33,42kg at baseline. A linear association existed between the handgrip strength values and the risk of all-cause death within 34.2kg. Handgrip strength can serve as an independent indicator for death risks.

Background. The aging population is increasingly susceptible to cardiovascular disease (CVD). Visit-to-visit variability in glucose and lipid levels both contributed to CVD risk independent of their mean values. However, whether variability in the triglyceride-glucose (TyG) index is a risk factor for CVD remains unknown. Research Design and Methods. In this retrospective study of electronic health records, 27,520 participants aged over 60 years were enrolled. The visit-to-visit variability of TyG index was calculated from annual health examination data and defined as average real variability (ARV), standard deviation (SD), or the coefficient of variability (CV). CVD events were identified from the chronic disease registry or follow-up database and included myocardial infarction, angina, coronary, and stroke. Multivariate Cox regression was used to examine the correlation between TyG variability and incident CVD. Results. Over a median follow-up of 6.2 years, there were 2,178 CVD events. When participants were divided into four quartiles according to their TyG variability, after adjusting for established CVD risk factors, subjects in the top quartile had (HR = 1.18, 95% CI 1.05–1.34, P=0.005) significantly higher CVD risk than those in the bottom quartile. The association remained significant in overweight individuals or those without diabetes (P

Due to the poor weldability of Inconel 738 alloy, defects (cracks, pores) always exist in the selective laser melting(SLM) process. In this paper, the molten pool evolution of the single track, including the morphology, porosity and crack formation, was systematically investigated by numerical simulation, and the effects of different preheating temperature and process parameters were verified by experimental analysis. The detailed temperature-dependent thermal physical properties were applied into the Volume of Fluid (VOF) method to simulate a powder bed computational domain which was established by Discrete Element Model (DEM).The simulation results show that the change of molten pool width by different laser power and preheating was not as significant as that of depth. The results also demonstrate that higher energy density and preheating temperature induced the generation of pores at the bottom of molten pool, which can be explained by the variation in cooling rates . Moreover, the change of temperature gradients in three-dimensional directions with the increase of preheating temperature was also investigated, which explained the reason for crack forming and extending through the center line. Finally, the evolution of molten pool at a higher preheating temperature 1000℃ was simulated to further underpin the positive effect of preheating on preventing cracks formation.

Abstract The reduction of the runoff to lake has become a common phenomenon of the inland lakes in northwest China, and the quantitative calculation of the driving factors affecting the runoff change has always been a challenge in lake research. In this pursuit, the present study was performed on Lake Daihai as an example, based on the relevant data from 1960 to 2018. The quantitative calculations of the runoff driving factors of Lake Daihai from 1982 to 2004 and from 2004 to 2017 were based on the slope change ratio of cumulative quantity (SCRCQ). It was concluded that human activities were the main factors affecting runoff change after 1982. The SCRCQ method was improved, which could carry out the quantitative calculations on the driving factors affecting the runoff change of the Lake Daihai from 1961 to 2017 on a yearly basis. The results show that the dominant factor of runoff changes in Lake Daihai was found to be the climate change before 1975, and it changed into human activities after 1975. Finally, based on the comparative analysis of the results of SCRCQ and improved SCRCQ, the advantages of improved SCRCQ were discussed. In addition, the reasons for the variation of the runoff to lake dominated by different factors in different periods for Lake Daihai were analyzed.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most effective and potentially curative treatment for a variety of hematologic malignancies. However, graft-versus-host disease (GVHD) is a major obstacle that limits wide application of allo-HSCT, despite the development of prophylactic strategies. Owing to experimental and clinical advances in the field, GVHD is characterized by disruption of the balance between effector and regulatory immune cells, resulting in higher inflammatory cytokine levels. A reduction in regulatory T cells (Tregs) has been associated with limiting recalibration of inflammatory overaction and maintaining immune tolerance. Moreover, accumulating evidence suggests that immunoregulation may be useful for preventing GVHD. As opposed to CD4+ Tregs, the CD8+ Tregs population, which constitutes an important proportion of all Tregs, efficiently attenuates GVHD while sparing graft-versus-leukemic (GVL) effects. CD8+ Tregs may provide another form of cellular therapy for preventing GVHD and preserving GVL effects, and understanding the underlying mechanisms that different from those of CD4+ Tregs is significant. In this review, we summarize preclinical experiments that have demonstrated the role of CD8+ Tregs during GVHD and attempted to obtain optimized CD8+ Tregs. Notably, although optimized CD8+ Tregs have obvious advantages, more exploration is needed to determine how to apply them in the clinic.

Organisms have developed common behavioral and physiological adaptations to the influence of the day/night cycle. The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input. The SCN may synchronize the growth hormone (GH) secretion rhythm with the dimming cycle through somatostatin neurons, and the change of the clock system may be related to the pulsatile release of GH. The GH—insulin-like growth factor 1 (IGF-1) axis and clock system may interact further on the metabolism through regulatory pathways in peripheral organs. We have summarized the current clinical and animal evidence on the interaction of clock systems with the GH—IGF-1 axis and discussed their effects on metabolism.