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29 results on '"Weiden, Jorieke"'

4. Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Author

Weiss, Lea, primary, Weiden, Jorieke, additional, Dölen, Yusuf, additional, Grad, Emilia M., additional, van Dinther, Eric A. W., additional, Schluck, Marjolein, additional, Eggermont, Loek J., additional, van Mierlo, Guido, additional, Gileadi, Uzi, additional, Bartoló-Ibars, Ariadna, additional, Raavé, René, additional, Gorris, Mark A. J., additional, Maassen, Lisa, additional, Verrijp, Kiek, additional, Valente, Michael, additional, Deplancke, Bart, additional, Verdoes, Martijn, additional, Benitez-Ribas, Daniel, additional, Heskamp, Sandra, additional, van Spriel, Annemiek B., additional, Figdor, Carl G., additional, and Hammink, Roel, additional

Published
2023
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8. Immunofilaments Provide a Nanoscale Platform for In Vivo T Cell Expansion and Cancer Immunotherapy

Author

Weiss, Lea, primary, Weiden, Jorieke, additional, Dölen, Yusuf, additional, Grad, Emilia M., additional, van Dinther, Eric A.W., additional, Schluck, Marjolein, additional, Eggermont, Loek J., additional, van Mierlo, Guido, additional, Gileadi, Uzi, additional, Bartoló-Ibars, Ariadna, additional, Raavé, René, additional, Gorris, Mark A.J., additional, Verrijp, Kiek, additional, Valente, Michael, additional, Deplancke, Bart, additional, Verdoes, Martijn, additional, Benitez-Ribas, Daniel, additional, Cerundolo, Vincenzo, additional, Heskamp, Sandra, additional, van Spriel, Annemiek B., additional, Figdor, Carl G., additional, and Hammink, Roel, additional

Published
2022
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10. Dictating Phenotype, Function, and Fate of Human T Cells with Co‐Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics

Author

Schluck, Marjolein, primary, Eggermont, Loek J., additional, Weiden, Jorieke, additional, Popelier, Carlijn, additional, Weiss, Lea, additional, Pilzecker, Bas, additional, Kolder, Sigrid, additional, Heinemans, Anne, additional, Rodriguez Mogeda, Carla, additional, Verdoes, Martijn, additional, Figdor, Carl G., additional, and Hammink, Roel, additional

Published
2022
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11. Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots

Author

Weiden, Jorieke, primary, Schluck, Marjolein, additional, Ioannidis, Melina, additional, van Dinther, Eric A. W., additional, Rezaeeyazdi, Mahboobeh, additional, Omar, Fawad, additional, Steuten, Juulke, additional, Voerman, Dion, additional, Tel, Jurjen, additional, Diken, Mustafa, additional, Bencherif, Sidi A., additional, Figdor, Carl G., additional, and Verdoes, Martijn, additional

Published
2021
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13. Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots

Author

Weiden, Jorieke, Schluck, Marjolein, Ioannidis, Melina, van Dinther, Eric A.W., Rezaeeyazdi, Mahboobeh, Omar, Fawad, Steuten, Juulke, Voerman, Dion, Tel, Jurjen, Diken, Mustafa, Bencherif, Sidi A., Figdor, Carl G., Verdoes, Martijn, Weiden, Jorieke, Schluck, Marjolein, Ioannidis, Melina, van Dinther, Eric A.W., Rezaeeyazdi, Mahboobeh, Omar, Fawad, Steuten, Juulke, Voerman, Dion, Tel, Jurjen, Diken, Mustafa, Bencherif, Sidi A., Figdor, Carl G., and Verdoes, Martijn

Abstract

Synthetic cancer vaccines may boost anticancer immune responses by co-delivering tumor antigens and adjuvants to dendritic cells (DCs). The accessibility of cancer vaccines to DCs and thereby the delivery efficiency of antigenic material greatly depends on the vaccine platform that is used. Three-dimensional scaffolds have been developed to deliver antigens and adjuvants locally in an immunostimulatory environment to DCs to enable sustained availability. However, current systems have little control over the release profiles of the cargo that is incorporated and are often characterized by an initial high-burst release. Here, an alternative system is designed that co-delivers antigens and adjuvants to DCs through cargo-loaded nanoparticles (NPs) incorporated within biomaterial-based scaffolds. This creates a programmable system with the potential for controlled delivery of their cargo to DCs. Cargo-loaded poly(d,l-lactic-co-glycolic acid) NPs are entrapped within the polymer walls of alginate cryogels with high efficiency while retaining the favorable physical properties of cryogels, including syringe injection. DCs cultured within these NP-loaded scaffolds acquire strong antigen-specific T cell-activating capabilities. These findings demonstrate that introduction of NPs into the walls of macroporous alginate cryogels creates a fully synthetic immunostimulatory niche that stimulates DCs and evokes strong antigen-specific T cell responses.

Published
2021

15. Human type 1 and type 2 conventional dendritic cells express indoleamine 2,3‐dioxygenase 1 with functional effects on T cell priming

Author

Sittig, Simone P., primary, van Beek, Jasper J. P., additional, Flórez‐Grau, Georgina, additional, Weiden, Jorieke, additional, Buschow, Sonja I., additional, van der Net, Mirjam C., additional, van Slooten, Rianne, additional, Verbeek, Marcel M., additional, Geurtz, P. Ben H., additional, Textor, Johannes, additional, Figdor, Carl G., additional, de Vries, I. Jolanda M., additional, and Schreibelt, Gerty, additional

Published
2021
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16. IL-17-producing [gamma][delta] T cells and neutrophils conspire to promote breast cancer metastasis

Author

Coffelt, Seth B., Kersten, Kelly, Doornebal, Chris W., Weiden, Jorieke, Vrijland, Kim, Hau, Cheei-Sing, Verstegen, Niels J. M., Ciampricotti, Metamia, Hawinkels, Lukas J. A. C., Jonkers, Jos, and de Visser, Karin E.

Subjects
Interleukins -- Physiological aspects, Breast cancer -- Physiological aspects, Cancer metastasis -- Physiological aspects, T cells -- Physiological aspects, Neutrophils -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Seth B. Coffelt [1]; Kelly Kersten [1]; Chris W. Doornebal [1]; Jorieke Weiden [1]; Kim Vrijland [1]; Cheei-Sing Hau [1]; Niels J. M. Verstegen [1]; Metamia Ciampricotti [1]; Lukas [...]

Published
2015
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17. Synthetic Semiflexible and Bioactive Brushes

Author

Voerman, Dion, primary, Schluck, Marjolein, additional, Weiden, Jorieke, additional, Joosten, Ben, additional, Eggermont, Loek J., additional, van den Eijnde, Tuur, additional, Ignacio, Bob, additional, Cambi, Alessandra, additional, Figdor, Carl G., additional, Kouwer, Paul H. J., additional, Verdoes, Martijn, additional, Hammink, Roel, additional, and Rowan, Alan E., additional

Published
2019
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19. Injectable biomimetic hydrogels as tools for efficient T Cell expansion and delivery

Author

Weiden, Jorieke, Voerman, Dion, Dölen, Yusuf, Das, Rajat K., van Duffelen, Anne, Hammink, Roel, Eggermont, Loek J., Rowan, Alan E., Tel, Jurjen, Figdor, Carl G., Weiden, Jorieke, Voerman, Dion, Dölen, Yusuf, Das, Rajat K., van Duffelen, Anne, Hammink, Roel, Eggermont, Loek J., Rowan, Alan E., Tel, Jurjen, and Figdor, Carl G.

Abstract

Biomaterial-based scaffolds are promising tools for controlled immunomodulation. They can be applied as three dimensional (3D) culture systems in vitro, whereas in vivo they may be used to dictate cellular localization and exert spatiotemporal control over cues presented to the immune system. As such, scaffolds can be exploited to enhance the efficacy of cancer immunotherapies such as adoptive T cell transfer, in which localization and persistence of tumor-specific T cells dictates treatment outcome. Biomimetic polyisocyanopeptide (PIC) hydrogels are polymeric scaffolds with beneficial characteristics as they display reversible thermally-induced gelation at temperatures above 16°C, which allows for their minimally invasive delivery via injection. Moreover, incorporation of azide-terminated monomers introduces functional handles that can be exploited to include immune cell-modulating cues. Here, we explore the potential of synthetic PIC hydrogels to promote the in vitro expansion and in vivo local delivery of pre-activated T cells. We found that PIC hydrogels support the survival and vigorous expansion of pre-stimulated T cells in vitro even at high cell densities, highlighting their potential as 3D culture systems for efficient expansion of T cells for their adoptive transfer. In particular, the reversible thermo-sensitive behavior of the PIC scaffolds favors straightforward recovery of cells. PIC hydrogels that were injected subcutaneously gelated instantly in vivo, after which a confined 3D structure was formed that remained localized for at least 4 weeks. Importantly, we noticed no signs of inflammation, indicating that PIC hydrogels are non-immunogenic. Cells co-delivered with PIC polymers were encapsulated within the scaffold in vivo. Cells egressed gradually from the PIC gel and migrated into distant organs. This confirms that PIC hydrogels can be used to locally deliver cells within a supportive environment. These results demonstrate that PIC hydrogels are

Published
2018

26. Synthetic immune niches for cancer immunotherapy

Author

Weiden, Jorieke, Tel, Jurjen, and Figdor, Carl G.

Abstract

Cancer immunotherapy can successfully promote long-term anticancer immune responses, although there is still only a limited number of patients who benefit from such treatment, and it can sometimes have severe treatment-associated adverse events. Compared with systemic immunomodulation, local immunomodulation may enable more effective treatment at lower doses and, at the same time, prevent systemic toxicity. Local delivery of engineered three-dimensional scaffolds may fulfil this role by acting as synthetic immune niches that boost anticancer immunity. In this Opinion article, we highlight the potential of scaffold-based adoptive cell transfer and scaffold-based cancer vaccines that, although applied locally, can promote systemic antitumour immunity. Furthermore, we discuss how scaffold-based cancer immunotherapy may contribute to the development of the next generation of cancer treatments.

Published
2018
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28. DNA origami nanostructures for controlled therapeutic drug delivery

Author

Weiden, Jorieke and Bastings, Maartje

Subjects
Nanomedicine, Selective targeting, Drug delivery, DNA nanomaterials, Nanotechnology, Controlled release, DNA origami, Translational therapy
Abstract

DNA nanostructures are emerging as a versatile platform for controlled drug delivery as a result of recent progress in production yield and strategies to obtain prolonged stability in biological environments. The construction of nanostructures from this unique biomaterial provides unparalleled control over structural and functional parameters. Recent applications of DNA origami-based nanocarriers for therapeutic drug delivery in preclinical phases highlight them as promising alternatives to conventional nanomaterials, as they benefit from the inherent favorable properties of DNA including biocompatibility and precise spatial addressability. By incorporating targeting aptamers and responsive properties into the nanocarrier design, more selective DNA origami-based nanocarriers are successfully prepared. On the other hand, current systems remain poorly understood in terms of biodistribution, final fate, and controlled drug release. As such, advances are needed to translate this material platform in its full potential for therapeutic applications.

29. Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Author

Weiss, Lea, Weiden, Jorieke, Dolen, Yusuf, Grad, Emilia M., van Dinther, Eric A. W., Schluck, Marjolein, Eggermont, Loek J., van Mierlo, Guido, Gileadi, Uzi, Bartolo-Ibars, Ariadna, Raave, Rene, Gorris, Mark A. J., Maassen, Lisa, Verrijp, Kiek, Valente, Michael, Deplancke, Bart, Verdoes, Martijn, Benitez-Ribas, Daniel, Heskamp, Sandra, van Spriel, Annemiek B., Figdor, Carl G., and Hammink, Roel

Subjects
nivolumab, vesicles, chimeric antigen receptor, efficacy, t cell expansion, immunofilaments, presenting cells, expansion, expression, melanoma, antitumor activity, immunotherapy, car t cells, infiltrating lymphocytes, antigen-specifict cells, synthetic dendritic cells
Abstract

Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their therapeuticpotential. We propose a radically different approach aimed at directexpansion of T cells in vivo, thereby omitting the need for large-scaleex vivo T cell production. We engineered nanosized immunofilaments(IFs), with a soluble semiflexible polyisocyanopeptide backbone thatpresents peptide-loaded major histocompatibility complexes and costimulatorymolecules multivalently. IFs readily activated and expanded antigen-specificT cells like natural APCs, as evidenced by transcriptomic analysesof T cells. Upon intravenous injection, IFs reach the spleen and lymphnodes and induce antigen-specific T cell responses in vivo. Moreover,IFs display strong antitumor efficacy resulting in inhibition of theformation of melanoma metastases and reduction of primary tumor growthin synergy with immune checkpoint blockade. In conclusion, nanosizedIFs represent a powerful modular platform for direct activation andexpansion of antigen-specific T cells in vivo, which can greatly contributeto cancer immunotherapy.

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