78 results on '"Weichun Li"'
Search Results
2. Five new species of Exalloniscus Stebbing, 1911 (Crustacea, Isopoda, Oniscidea) from China
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Chao Jiang, Chonghui Yao, Luqi Huang, and Weichun Li
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Biology (General) ,QH301-705.5 - Abstract
Exalloniscus Stebbing, 1911 is investigated from China, and eleven species of the genus are now recorded from China. Five of them are described as new: E. duospinatus Li & Jiang, sp. nov., E. curvispinatus Li & Jiang, sp. nov., E. triangulus Li & Jiang, sp. nov., E. tridentatus Li & Jiang, sp. nov. and E. taitii Li & Jiang, sp. nov. A map of China showing the recorded localities of Exalloniscus members is provided.
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- 2024
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3. Ginsenoside Rg3 targets glycosylation of PD-L1 to enhance anti-tumor immunity in non-small cell lung cancer
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Wei Wang, Min Kong, Fu Shen, Ping Li, Cheng Chen, Yueqin Li, Cheng Li, Zhiqiang Qian, Aihua Zhong, Yuhua Wang, Liang Yang, Fangkai He, and Weichun Li
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ginsenoside Rg3 ,non-small cell lung cancer ,PD-L1 ,glycosylation ,T cell activation ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundReactivate the T cell immunity by PD-1/PD-L1 checkpoint blockade is widely used in non-small cell lung cancer (NSCLC) patients, while the post-translational modification of Programmed death ligand-1 (PD-L1) is commonly existed in various cancer cells, thus increases the complexity and difficulty in therapy development. Ginsenoside Rg3 is an active component of traditional Chinese herb Ginseng with multiple pharmacological effects including immune regulation. However, the effect on the glycosylation of PD-L1 is unknown.MethodsNSCLC cell lines were tested for glycosylation of PD-L1, and the potential mechanisms were investigated. Tumor cell-T cell coculture experiment was conducted and the activation of T cells and cytotoxicity were measured by flow cytometry. In vivo xenograft mouse tumor model was used to investigate the effects of Rg3 on PD-L1-mediated immunosuppression and tumor growth.ResultsHere, we identified PD-L1 is widely N-linked glycosylated in NSCLC cell lines, while Rg3 could inhibit the glycosylation of PD-L1 by downregulating the EGFR signaling and further activate GSK3b-mediated degradation, thus resulted in reduced PD-L1 expression. Moreover, the inhibition of PD-L1 glycosylation promoted the activation and cytotoxicity of T cells under coculture condition. In addition, Rg3 could decrease the tumor volume and enhance anti-tumor T cell immunity as evidence by the upregulated expression of Granzyme B and perforin in CD8+T cells, along with elevated serum IL-2, IFN-g and TNF-a level in Rg3-treated mice.ConclusionsThese results suggest that Rg3 inhibits PD-L1 glycosylation and thus enhance anti-tumor immunity, which provide new therapeutic insight into drug discovery.
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- 2024
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4. Integrative taxonomy on the rare sky-island Ligidium species from southwest China (Isopoda, Oniscidea, Ligiidae)
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Jin Wang, Jingbo Yang, Xuegang Zeng, and Weichun Li
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Geometric morphometrics ,Molecular delimitation ,Morphology ,New species ,Terrestrial isopods ,Zoology ,QL1-991 - Abstract
Abstract Background The sky-island Ligidium species fauna in southwest China is poorly known. Before this study, six of the seven sky-island species of the genus were known to be endemic to southwest China. In morphology, Ligidium species are often difficult to identify, and an appraisal of integrative taxonomy is needed. Results We integrated morphology and molecular analyses to delimit Ligidium species. Molecular species delimitation based on distance- and evolutionary models recovered seven-candidate lineages from five gene markers (COI, 12S rRNA, 18S rRNA, 28S rRNA and NAK). We also estimated that the species divergences of sky-island Ligidium in southwest China started in late Eocene (40.97 Mya) to middle Miocene (15.19 Mya). Four new species (L. duospinatum Li, sp. nov., L. acuminatum Li, sp. nov., L. rotundum Li, sp. nov. and L. tridentatum Li, sp. nov.) are described. Morphological confusion among L. denticulatum Shen, 1949, L. inerme Nunomura & Xie, 2000 and L. sichuanense Nunomura, 2002 is clarified by integrative taxonomy. Conclusion This work confirms that an integrative approach to Ligidium taxonomy is fundamental for objective classification, and deduced the uplift of Qinghai-Tibetan Plateau in the late Eocene and middle Miocene as one of the principal reasons for the species divergences of sky-island Ligidium in southwest China. We also inferred that sky-island mountains have a huge reserve of higher Ligidium species diversity.
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- 2022
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5. Impact of post-thoracotomy analgesia with dexmedetomidine and morphine on immunocytes: a randomized clinical trial
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Pengfei Lei, Jin Wang, Shan Gao, Bo Du, Hao Wang, Weichun Li, Fei Shi, and Aijun Shan
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Toracotomia ,Dexmedetomidina ,Morfina ,Analgesia ,Linfócitos ,Anesthesiology ,RD78.3-87.3 - Abstract
Objective: This study aimed to investigate the impact of post-thoracotomy analgesia with dexmedetomidine and morphine on immunocytes. Methods: A total of 118 patients with post-thoracotomy Patient-Controlled Intravenous Analgesia (PCIA) in our hospital from March 2016 to July 2018 were randomly selected and divided into the Composite (COM) Group (57 patients administered with dexmedetomidine [1.0 μg.kg-1 body weight] and morphine [0.48 mg.kg-1 body weight]) and the Morphine (MOR) group (61 patients administered with morphine [0.48 mg.kg-1]). The values of lymphocyte subsets (CD3+, CD4+, and CD8+) and Natural Killer cells in the peripheral blood of these two groups were detected by FACSCalibur flow cytometry at different time points (before anesthesia induction [T0], immediately after tracheal extubation [T1], 12 hours after surgery [T2], 24 hours after surgery [T3], 48 hours after surgery [T4], 72 hours after surgery [T5], and 7 days after surgery [T6]). The doses of morphine at T3 to T5 and the adverse reactions between the two groups were also recorded and compared. Results: The CD3+ level and the CD4+/CD8+ ratio at T2 to T5 and the CD4+ level and NK cells at T3 to T5 were significantly higher in the COM Group than in the MOR Group (p< 0.05). The postoperative morphine dose and the incidence of postoperative itching, nausea, and vomiting were significantly lower in the COM Group than in the MOR Group (p< 0.05). Conclusions: Dexmedetomidine combined with morphine for post-thoracotomy PCIA can improve the function of immunocytes, reduce morphine consumption, and reduce the adverse reactions during analgesia induction. Resumo: Objetivo: Estudar o impacto em linfócitos causado pelo uso da dexmedetomidina associada à morfina para analgesia pós-toracotomia. Método: Um total de 118 pacientes utilizando Analgesia Intravenosa Controlada pelo Paciente (AICP) pós-toracotomia em nosso hospital de Março de 2016 a Julho de 2018 foram selecionados aleatoriamente e divididos em dois grupos: o Grupo Gombinado [COM, 57 pacientes que receberam dexmedetomidina (1,0 μg.kg-1 de peso corpóreo) associada à morfina (0,48 mg.kg-1 de peso corpóreo)] e o Grupo Morfina [MOR, 61 pacientes, que receberam somente morfina (0,48 mg.kg-1)]. Os valores dos subconjuntos de linfócitos (CD3+, CD4+ e CD8+) e das células NK no sangue periférico desses dois grupos foram medidos por citometria de fluxo FACSCalibur em diferentes momentos do estudo [antes da indução anestésica (T0), imediatamente após extubação traqueal (T1), 12 horas após a cirurgia (T2), 24 horas após a cirurgia (T3), 48 horas após a cirurgia (T4), 72 horas após a cirurgia (T5) e 7 dias após a cirurgia (T6)]. As doses de morfina do momento T3 ao T5 e as reações adversas entre os dois grupos também foram registradas e comparadas. Resultados: O nível de CD3+ e a razão CD4+/CD8+ de T2 a T5, e o nível de CD4+ e as células NK de T3 a T5 do Grupo COM foram significantemente maiores (p < 0,05), quando comparados ao Grupo MOR. A dose de morfina no pós-operatório e a incidência de prurido, náusea e vômito no pós-operatório foram significantemente menores no grupo MOR (p < 0,05). Conclusões: Dexmedetomidina combinada com morfina para AICP no período pós-toracotomia pode melhorar a função dos linfócitos, reduzir o consumo de morfina e diminuir reações adversas durante a analgesia.
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- 2020
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6. Improved Lattice-Based Signcryption in the Standard Model
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Xiaopeng Yang, Hao Cao, Weichun Li, and Hejun Xuan
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Signcryption ,lattice ,encapsulation ,ring learning with errors (RLWE) problem ,ideal short integer solution (ISIS) problem ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Signcryption is a basic cryptographic primitive that simultaneously captures the functions of encryption and signature. To realize comprehensive information security against quantum computing attacks, lattice-based signcryption schemes have been successively proposed. However, the performance of signcryption schemes should be improved in the lattice setting. An efficient lattice-based signcryption scheme in the standard model is proposed in this paper. Under the ring learning with errors (RLWE) assumption and the ideal short integer solution (ISIS) assumption, the proposed signcryption scheme achieves indistinguishability against adaptive chosen ciphertext attacks (IND-CCA2) and existential unforgeability under an adaptive chosen-message attack (EUF-ACMA). Our scheme not only reduces the communication and computational overhead but also realizes a new design that combines the partitioning technique with the idea of tag-based key encapsulation. The performance analysis results show that our scheme is more efficient than previous lattice-based signcryption schemes in the standard model.
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- 2019
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7. Immunotherapy-Associated Pancreatic Adverse Events: Current Understanding of Their Mechanism, Diagnosis, and Management
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Ya Liu, Hao Zhang, Li Zhou, Weichun Li, Le Yang, Wen Li, Kezhou Li, and Xubao Liu
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immune checkpoint inhibitors ,immune-related adverse events ,ICIs associated with diabetes mellitus ,amylase/lipase ,pancreatitis ,pancreatic exocrine insufficiency ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Immune checkpoint inhibitors (ICIs) such as anti-programmed death-1 (PD-1) and its ligand PD-L1 and anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibodies, are involved in T cell-mediated immune response augmentation and promote anti-tumor immunity. Cancer patients treated with combination of immunotherapy, chemotherapy, radiotherapy, and targeted therapy exhibit superior clinical outcomes and tolerance compared with patients treated with monotherapies. However, immutherapy is associated with several concomitant immune-related adverse events (irAEs). For instance, IrAEs interferes with function of gastrointestinal tract, endocrine, dermatological, nervous system and musculoskeletal systems. ICIs-associated pancreatic injury might causes decrease in endocrine and exocrine pancreatic function, resulting in metabolic and nutritional disorders. Clinicians who administer immune checkpoint inhibitors to cancer patients are diagnosed with hyperglycemia, abdominal pain and steatorrhea. Currently, the precise mechanism of ICIs-associated pancreatic injury has not been fully explored. This paper summarizes incidence, diagnosis, clinical characteristics, potential mechanisms, and treatment management patterns of ICIs-associated pancreatic AEs based on previous studies. In addition, possible management approaches of these adverse effects are presented in this paper. in the findings summarized in this paper lay a basis for management of ICIs-associated pancreatic AEs and expanding future immunotherapy applications.
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- 2021
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8. A Clinical Study of the Intra-Neuroendoscopic Technique for the Treatment of Subacute-Chronic and Chronic Septal Subdural Hematoma
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Bo Du, Jianzhong Xu, Jintao Hu, Xianliang Zhong, Jian Liang, Pengfei Lei, Hao Wang, Weichun Li, Yuping Peng, Aijun Shan, and Yujuan Zhang
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intra-neuroendoscopic technique (INET) ,transparent sheath ,chronic subdural hematoma (CSDH) ,inflammatory factor ,pathology ,prognosis ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective: The surgical technique, safety, efficacy, and clinical application value of the intra-neuroendoscopic technique (INET) for the treatment of subacute-chronic and chronic septal subdural hematoma was investigated based on the structure and pathological features of the hematoma wall, and the critical factors of hematoma growth and recurrence were determined, in order to provide reference for clinical drug treatment.Methods: This was non-randomized concurrent control study. A total of 94 patients who met the inclusion criteria were recruited between May 2015 and February 2019 and were divided into the INET treatment group (INET group, 45 cases) and the burr hole drainage (BHD) treatment group (control group, 49 cases). The hematoma fluid components and the morphological structure and pathological characteristics of the hematoma wall were analyzed, and the surgical duration, subdural drainage tube (SDT) placement duration, intracranial infection rate, Bender grade at the 1 month post-operative follow-up and hematoma recurrence rate within the 6 months of post-operative follow-up were compared between the two groups. A multiple logistic regression model was established to analyze the risk factors associated with recurrence within 6 months.Results: Intraoperative endoscopy showed that the adhesion bands that formed early in the hematoma cavity were strip-like and that those that formed late were lock-column-like. The hematoma cavity was divided into different-sized chambers with by these strips/columns. Pathological sections of cyst wall reveled angiogenesis inside the cyst and mucus-like changes, rupture and hemorrhage in the vascular wall. Obvious inflammatory cell infiltration and fibrous connective tissue hyperplasia were observed in the cyst wall. The osmotic pressure of the hematoma fluid was not significantly different from that of the peripheral venous blood [(296.7 ± 10.3) mOsm/kg vs. (291.5 ± 12.4) mOsm/kg, p = 0.68]. However, the D-dimer contents which reflect the severity of fibrinolysis in the hematoma and the proinflammatory cytokine interleukin 6 (IL-6) were significantly higher in the hematoma fluid than in the peripheral venous blood. The surgery duration for the INET group was significantly longer than that for the control group [(60.4 ± 10.6) min vs. (44.1 ± 9.8) min, p = 0.00], but both the hematoma recurrence rate within 6 months of post-operative follow-up (4.4 vs. 24.5%, p = 0.00) and the SDT placement duration [(2.1 ± 0.6) d vs. (3.9 ± 0.7) d, p = 0.00] for the INET group were both lower than those for the control group. The intracranial infection rate did not differ significantly between the two groups (4.4 vs. 10.2%, p = 0.50). The overall effective rate of the Bender grade at 1 month of follow-up did not differ significantly between the two groups (95.6 vs. 87.8%, p = 0.32), but the proportion of patients who recovered to Bender grade 0 with no symptoms was significantly higher in the INET group than in the control group (86.7 vs. 67.3%, p = 0.03). Multiple logistic regression analysis showed that INET surgery [odds ratio (OR) 3.71, 95% confidence interval (CI) 1.31–9.62, p = 0.02], age of 65 years or younger (OR 1.51, 95% CI 1.05–2.87, p = 0.03) and unilateral subdural hematoma (OR 1.76, 95% CI 1.05–3.41, p = 0.02) were independent factors that reduced the post-operative recurrence rate.Conclusion: The INET surgical plan based on the structure and pathological features of the subacute-chronic and chronic subdural hematoma wall can reduce the recurrence rate and improve the clinical prognosis.Trial registration:ClinicalTrials.gov, NCT02515903. Registered 5 August, 2015.
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- 2020
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9. Experimental Demonstration of a Multicorrugation-Pitch-Modulated (MCPM) DFB Semiconductor Laser Based on Reconstruction-Equivalent-Chirp Technology
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Jilin Zheng, Yunshan Zhang, Yuechun Shi, Weichun Li, Bocang Qiu, Jun Lu, Tingting Zhang, and Xiangfei Chen
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DFB semiconductor laser ,sampled grating ,spatial-hole-burning ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
A multicorrugation-pitch-modulated (MCPM) distributed-feedback semiconductor laser is experimentally demonstrated for the first time to achieve stable single longitudinal mode (SLM) performance. The MCPM structure was equivalently realized based on a sampled grating using reconstruction equivalent chirp (REC) technology. The proposed REC-MCPM structure can effectively flatten the optical intensity distribution along the laser cavity, leading to the strong suppression in spatial hole burning. In addition, the REC-MCPM grating structures can be readily fabricated using conventional holographic lithography combined with low-cost standard micrometer-level photolithography. A proof-of-principle study both in a simulation and an experiment is presented in this paper. The fabricated 400- $\mu\hbox{m} $-long REC-MCPM semiconductor laser shows very good SLM performance with SMSRs being more than 42 dB under test conditions of a large injection current range (up to 300 mA) and different ambient temperatures.
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- 2015
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10. A new species of Metaeuchromius (Lepidoptera, Crambidae) from the Tibetan glacier area of China
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Weichun Li and Dong Liu
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Zoology ,QL1-991 - Abstract
Metaeuchromius glacialis Li, sp. n. is described from the Tibetan glacier area of China. The new species is similar to M. circe Bleszynski by the distal projection of costa exceeding the apex of valva, and the phallus with strong spine-like cornuti in the male genitalia. Images of male adult, tympanal and scent organs as well as genitalia of the new species are provided.
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- 2015
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11. Impact of post-thoracotomy analgesia with dexmedetomidine and morphine on immunocytes: a randomized clinical trial
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Pengfei Lei, Jin Wang, Shan Gao, Bo Du, Hao Wang, Weichun Li, Fei Shi, and Aijun Shan
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Thoracotomy ,Dexmedetomidine ,Morphine ,Analgesia ,Immunocytes ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Objective This study aimed to investigate the impact of post-thoracotomy analgesia with dexmedetomidine and morphine on immunocytes. Methods A total of 118 patients with post-thoracotomy Patient-Controlled Intravenous Analgesia (PCIA) in our hospital from March 2016 to July 2018 were randomly selected and divided into the Composite (COM) Group (57 patients administered with dexmedetomidine [1.0 µg.kg-1 body weight] and morphine [0.48 mg.kg-1 body weight]) and the Morphine (MOR) group (61 patients administered with morphine [0.48 mg.kg-1]). The values of lymphocyte subsets (CD3+, CD4+, and CD8+) and Natural Killer cells in the peripheral blood of these two groups were detected by FACSCalibur flow cytometry at different time points (before anesthesia induction [T0], immediately after tracheal extubation [T1], 12 hours after surgery [T2], 24 hours after surgery [T3], 48 hours after surgery [T4], 72 hours after surgery [T5], and 7 days after surgery [T6]). The doses of morphine at T3 to T5 and the adverse reactions between the two groups were also recorded and compared. Results The CD3+ level and the CD4+/CD8+ ratio at T2 to T5 and the CD4+ level and NK cells at T3 to T5 were significantly higher in the COM Group than in the MOR Group (p< 0.05). The postoperative morphine dose and the incidence of postoperative itching, nausea, and vomiting were significantly lower in the COM Group than in the MOR Group (p< 0.05). Conclusions Dexmedetomidine combined with morphine for post-thoracotomy PCIA can improve the function of immunocytes, reduce morphine consumption, and reduce the adverse reactions during analgesia induction.
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12. Fabricating a novel supramolecular light-activated platform based on internal-driven forces induced by the UV-light
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Xiaoni Qi, Weichun Li, Bingbing Shi, Youming Zhang, Hong Yao, Qi Lin, and Taibao Wei
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General Chemistry - Published
- 2022
13. Capture and Removal of Iodine by a Fluorinated Leaning Pillar[6]arene with Host–Guest Interactions
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Bingbing Shi, Weichun Li, Peng Qin, Tai-Bao Wei, Wen-Juan Qu, Yuezhou Liu, and Qi Lin
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Biomaterials ,Renewable Energy, Sustainability and the Environment ,Materials Chemistry ,Energy Engineering and Power Technology - Published
- 2023
14. Fluorinated leaning pillar[6]arene: synthesis, structure and selective iodide anion binding by anion–π interactions
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Weichun Li, Peng Qin, Xing-Xing Zhao, Wen-Juan Qu, Qi Lin, Hong Yao, Tai-Bao Wei, You-Ming Zhang, Yuezhou Liu, and Bingbing Shi
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Quaternary Ammonium Compounds ,Organic Chemistry ,Electrons ,Iodides ,Physical and Theoretical Chemistry ,Biochemistry - Abstract
Anion recognition has continuously attracted significant attention due to its important role in environmental and biological sciences. Here, we have designed and synthesized an electron-deficient fluorinated leaning pillar[6]arene 1 that contains two tetrafluoro-benzene units. The electron-deficient fluorinated leaning pillar[6]arene 1 is capable of selectively recognizing iodide anions to form a host-guest complex with 1 : 1 stoichiometry driven by anion-π interactions. Our work ascribes this selective recognition to the preorganization of macrocycles, suitable cavity size, and the effect of anion-π interactions. The innovative application of this macrocycle offers us a new avenue for the design of selective receptors for anions and electron-deficient macrocyclic arenes.
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- 2022
15. Effect and mechanism of BDNF/TrkB signaling on vestibular compensation
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Dehong Mao, Weichun Li, Linglong Li, Xiaoying Fang, Zhongmei He, Feng Zhang, Wei Xuan, and Jiao Deng
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Male ,medicine.medical_specialty ,Time Factors ,Medial vestibular nucleus ,Bioengineering ,Tropomyosin receptor kinase B ,BDNF/TrkB signaling ,Applied Microbiology and Biotechnology ,Rats, Sprague-Dawley ,astrocyte ,Neurotrophic factors ,Internal medicine ,GABAergic neuron ,medicine ,Animals ,Receptor, trkB ,GABAergic Neurons ,Cell Proliferation ,vestibular compensation ,GABAAR ,Behavior, Animal ,Glial fibrillary acidic protein ,biology ,Chemistry ,Brain-Derived Neurotrophic Factor ,General Medicine ,Vestibular nerve ,Lateral vestibular nucleus ,medicine.anatomical_structure ,Endocrinology ,nervous system ,Astrocytes ,biology.protein ,GABAergic ,Vestibule, Labyrinth ,TP248.13-248.65 ,Signal Transduction ,Research Article ,Research Paper ,Biotechnology ,Astrocyte - Abstract
Brain-derived neurotrophic factor (BDNF) regulates neuronal plasticity by targeting the tyrosine kinase B receptor (TrkB) receptor, but limited researches concentrate on the role of BDNF/TrkB signaling in vestibular compensation. In this study, rats with unilateral vestibular dysfunction were established by unilateral labyrinthectomy (UL) and infusion with siBDNF or 7, 8-Dihydroxyflavone (7,8-DHF, a TrkB receptor agonist). The behavioral scores of rats with vestibular deficits were determined and the rotarod test was performed after UL. BDNF and TrkB levels after UL were determined by western blot and quantitative reverse transcription PCR (qRT-PCR). 5-bromo-2ʹ-deoxyuridine (BrdU)-positive cells (newly generated cells) and GAD67-positive cells (GABAergic neurons) were identified by immunohistochemistry. Glial fibrillary acidic protein (GFAP) (astrocyte marker)-positive cells were identified and GABA type A receptor (GABAAR) expression was detected by immunofluorescence. We found that after UL, BDNF and TrkB levels were up-regulated with a maximum value at 4 h, and then progressively down-regulated during 4 h ~ 7 d. Blocking BDNF/TrkB signaling inhibited the recovery from vestibular deficits, decreased the numbers of newly generated cells and astrocytes in medial vestibular nucleus (MVN), inferior vestibular nerve (IVN), superior vestibular nerve (SVN) and lateral vestibular nucleus (LVN), and disrupted the balances of GABAergic neurons and GABAAR expressions in the left (lesioned) side and right (intact) side of MVN, whereas activation of BDNF/TrkB signaling caused opposite results. The current study indicated that BDNF/TrkB signaling avails vestibular compensation, depending on the number of newly generated cells and astrocytes, the rebalance of GABAergic neurons, and GABAAR expression in bilateral MVN.
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- 2021
16. Effects of Vasculogenic Mimicry on Postoperative Recurrence and Progression of Non-Small Cell Lung Cancer
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Yanqing Liu, Aiqin Peng, Zhisheng Zhang, Jijun You, Jue Chen, Baoyong Ling, Yayun Qian, and Weichun Li
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Oncology ,medicine.medical_specialty ,Poor prognosis ,Tumor differentiation ,business.industry ,Distant metastasis ,General Medicine ,medicine.disease ,respiratory tract diseases ,Internal medicine ,Overall survival ,Medicine ,Vasculogenic mimicry ,Non small cell ,Stage (cooking) ,business ,Lung cancer - Abstract
Vasculogenic mimicry (VM) in lung cancer shortens overall survival (OS) but its’ associations with postoperative recurrence and progression of early non-small cell lung cancer (NSCLC) remain unclear. The purpose of this study was to analyze the association of VM with postoperative recurrence and progression of NSCLC as well as the effect of VM on postoperative recurrence-free survival (RFS). This study included NSCLC patients and detected VM in surgical specimens. The associations of VM with the recurrence and progression were analyzed to assess the effect of VM on postoperative RFS in NSCLC. A total of 80 NSCLC cases were followed up for 3 years. During follow-up, 35 cases showed recurrence and progression where 5 (6.25%) cases had simple local recurrence and the other 30 (37.5%) cases had distant metastasis. The recurrence and progression rates in the first, second, and third years were 12.50%, 23.75%, and 7.50%, respectively. The median RFS was 14.2 months. VM was detected in 30 out of 80 cases and was significantly correlated with tumor differentiation (r = 0.365) and clinical stage (r = 0.374) (both, P = 0.001). Local recurrence of NSCLC was not correlated with VM, unlike distant metastasis (r = 0.598, P < 0.001). Average RFS was significantly longer in NSCLC patients without VM compared with the VM group 3 years post-operation (32 months versus 18 months, log-rank test P < 0.001). Considering these, VM is significantly correlated with postoperative distant metastasis of NSCLC in which it is of a certain value for predicting poor prognosis in NSCLC.
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- 2021
17. SLCO4A1‐AS1 regulates laryngeal squamous cell carcinoma cell phenotypes via the Wnt pathway
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Weichun Li, Feng Zhang, Xu Zhang, Linglong Li, Zhongmei He, and Dehong Mao
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medicine.diagnostic_test ,Competing endogenous RNA ,Chemistry ,Cell ,Wnt signaling pathway ,030206 dentistry ,Antisense RNA ,Flow cytometry ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Otorhinolaryngology ,Downregulation and upregulation ,Apoptosis ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,Signal transduction ,General Dentistry - Abstract
Aim Long noncoding RNAs were widely reported to regulate laryngeal squamous cell carcinoma (LSCC), a prevalent tumor in the head and neck. We aimed to investigate the role of solute carrier organic anion transporter family member 4A1 antisense RNA 1 (SLCO4A1-AS1) in LSCC. Materials & methods CCK-8 and colony formation assays were conducted to examine the viability and proliferation of LSCC cells. The apoptosis of LSCC cells was evaluated using flow cytometry and TUNEL assays. The distribution of SLCO4A1-AS1 in LSCC cells was detected by subcellular fractionation assay. The interaction between molecules was confirmed using luciferase reporter assay. Results SLCO4A1-AS1 was overexpressed in LSCC tissues and cells. Furthermore, silenced SLCO4A1-AS1 repressed the proliferation and facilitated apoptosis of LSCC cells. Mechanistical investigation revealed that SLCO4A1-AS1 was a competing endogenous RNA (ceRNA) to upregulate SETD7 by binding with miR-7855-p. Additionally, SLCO4A1-AS1 positively regulated the Wnt/β-catenin signaling pathway by upregulating SETD7. Rescue experiments demonstrated that SLCO4A1-AS1 promoted LSCC proliferation and inhibited LSCC apoptosis by upregulation of SETD7 and activation of the Wnt/β-catenin pathway. Conclusion SLCO4A1-AS1 promotes proliferation and inhibits apoptosis of LSCC cells by upregulation of SETD7 in a miR-7855-5p dependent way to activate the Wnt/β-catenin pathway.
- Published
- 2021
18. Trachelipus rathkii (Brandt, 1833) in Alberta, the First Report of a Terrestrial Isopod from the Prairie Provinces, Canada (Isopoda: Oniscidea)
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Weichun Li
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Ecology ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
19. Detection of Aliphatic Aldehydes by a Pillar[5]arene-based Fluorescent Supramolecular Polymer with Vaporchromic Behavior
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Bingbing Shi, Yongping Chai, Peng Qin, Xing‐Xing Zhao, Weichun Li, You‐Ming Zhang, Tai‐Bao Wei, Qi Lin, Hong Yao, and Wen‐Juan Qu
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Quaternary Ammonium Compounds ,Aldehydes ,Polymers ,Organic Chemistry ,General Chemistry ,Calixarenes ,Coloring Agents ,Biochemistry - Abstract
The detection of volatile aliphatic aldehydes is of significance because of their chemical toxicity, physical volatility and widespread applications in chemical industrial processes. In this work, the direct detection of aliphatic aldehydes is tackled using a pillar[5]arene-based fluorescent supramolecular polymer with vaporchromic behavior. Thin films with strong orange-yellow fluorescence are prepared by coating the linear supramolecular polymer on glass sheets. When the thin films are exposed to aliphatic aldehydes with different carbon chain lengths, they can selectively sensing n-butyraldehyde (C
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- 2022
20. A third species of Parakermania Vandel, 1973 (Isopoda: Oniscidea: Armadillidae) from China
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XINKAI HONG, YUTAO WANG, and WEICHUN LI
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China ,Arthropoda ,Animalia ,Armadillidae ,Animals ,Animal Science and Zoology ,Biodiversity ,Malacostraca ,Animal Distribution ,Ecology, Evolution, Behavior and Systematics ,Taxonomy ,Isopoda - Abstract
Parakermania longa sp. nov., the third species of the woodlouse genus Parakermania Vandel, 1973 is described and illustrated from China. The new species differs from the other two congeners in having a different number of dorsal tubercles, and two well-developed ornamentations on the outer sides of the sixth pereonite going beyond the apex of telson. A key to Parakermania species is provided.
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- 2022
21. The steatosis-associated fibrosis estimator (SAFE) outperformed the FIB-4 score in screening the population for liver disease
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Mingkai Li, Ying Lin, Hongsheng Yu, Weichun Lin, Jianning Chen, Yidong Yang, and Bin Wu
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Fibrosis ,NAFLD ,Noninvasive test ,Referral ,Survival ,Specialties of internal medicine ,RC581-951 - Abstract
Introduction and Objectives: Assessing fibrosis risk noninvasively is essential. The steatosis-associated fibrosis estimator (SAFE) score shows promise but needs validation. Patients and Methods: This was a three-part study. In part 1, we compared the SAFE score with the Fibrosis-4 (FIB-4) and NAFLD fibrosis score (NFS) in the National Health and Nutrition Examination Survey (NHANES) cohort (2017–2020), using transient elastography (TE) as screening reference. In part 2, we examined patients who underwent liver biopsies at an Asian center between 2018 and 2020 to assess these models in various liver diseases. In part 3, the SAFE score was applied to adults in the NHANES cohort (1999–2016) to assess the correlation with mortality. Results: In part 1, we studied 6,677 patients, comprising 595 screening positive (TE ≥8 kPa). SAFE (cutoff 100) displayed a lower proportion of false positives (10.4 %) than FIB-4 (cutoff 1.3) and NFS (cutoff -1.455) (22.1 % and 43.6 %) while retaining a low proportion of false negatives (5.5 %). In part 2, SAFE outperformed FIB-4 (P = 0.04) and NFS (P = 0.04) in staging significant fibrosis (≥S2) in NAFLD and had similar accuracies in other etiologies. In part 3, the FIB-4, NFS, and SAFE score were associated with all-cause mortality in the general population, with c-statistics of 0.738, 0.736, and 0.759, respectively. Conclusions: The SAFE score reduced futile referrals more effectively than FIB-4 without raising the missed TE ≥ 8 kPa rate. It correlated with all-cause mortality in the general population and excelled in staging significant fibrosis in NAFLD.
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- 2024
- Full Text
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22. Impacto da analgesia pós‐toracotomia com dexmedetomidina e morfina em imunócitos: estudo randomizado
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Weichun Li, Shan Gao, Bo Du, Pengfei Lei, Aijun Shan, Fei Shi, Jin Wang, and Hao Wang
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03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,030202 anesthesiology - Abstract
Resumo Objetivo Estudar o impacto em linfocitos causado pelo uso da dexmedetomidina associada a morfina para analgesia pos‐toracotomia. Metodo Um total de 118 pacientes utilizando Analgesia Intravenosa Controlada pelo Paciente (AICP) pos‐toracotomia em nosso hospital, de marco de 2016 a julho de 2018, foram selecionados aleatoriamente e divididos em dois grupos: o Grupo Combinado [COM, 57 pacientes que receberam dexmedetomidina (1,0 μg.kg‐1 de peso corporeo) associada a morfina (0,48 mg.kg‐1 de peso corporeo)] e o Grupo Morfina [MOR, 61 pacientes, que receberam somente morfina (0,48 mg.kg‐)]. Os valores dos subconjuntos de linfocitos (CD3+, CD4+ e CD8+) e das celulas NK no sangue periferico desses dois grupos foram medidos por citometria de fluxo FACSCalibur em diferentes momentos do estudo [antes da inducao anestesica (T0), imediatamente apos extubacao traqueal (T1), 12 horas apos a cirurgia (T2), 24 horas apos a cirurgia (T3), 48 horas apos a cirurgia (T4), 72 horas apos a cirurgia (T5) e 7 dias apos a cirurgia (T6)]. As doses de morfina do momento T3 ao T5 e as reacoes adversas entre os dois grupos tambem foram registradas e comparadas. Resultados O nivel de CD3+ e a razao CD4+/CD8+ de T2 a T5, e o nivel de CD4+ e as celulas NK de T3 a T5 do Grupo COM foram significantemente maiores (p Conclusoes Dexmedetomidina combinada com morfina para AICP no periodo pos‐toracotomia pode melhorar a funcao dos linfocitos, reduzir o consumo de morfina e diminuir reacoes adversas durante a analgesia.
- Published
- 2020
23. A Sustainable and Comprehensive Framework for Knowledge Transfer in MNCs: An Empirical Examination Based on Country, Company and Individual Levels of Chinese MNCs
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Junshuai Cheng, Qaisar Iqbal, Guangmeng Ji, and Weichun Li
- Subjects
Renewable Energy, Sustainability and the Environment ,knowledge transfer ,Chinese MNCs ,spatial perspective ,knowledge management ,Geography, Planning and Development ,Building and Construction ,Management, Monitoring, Policy and Law - Abstract
The shift in business perspective helps test, extend, and build innovative management theory, then sustainably expand and enhance the understanding of business and management. The development of the global business model makes knowledge transfer not only focus on the process itself, but especially the knowledge transfer of multinational companies (MNCs). Thus, this study is based on the knowledge-based view (KBV) theory, using a sustainable perspective and establishing a spatial model, which includes three aspects: county, company, and employee. It has been mentioned many times in previous research that it is necessary to build such a comprehensive model and completely study the influence factors, while this study is the first to carry out an effective empirical way to test which levels have significant factors that impact the knowledge transfer of Chinese MNCs. Moreover, with the advancement of technology, such as video conference and remote online cooperation, whether human abilities and traits (cultural intelligence) still occupy a specific position, as the conclusions of previous studies have proved, is also a focus of this study. Therefore, this empirical study uses the partial least squares structural equation (PLS-SEM) to test the influence of different aspects on knowledge transfer in Chinese MNCs. Although this study just chose Chinese MNCs as the case, the comprehensive results make up and rediscover some tacit factors of the impact on knowledge transfer, and then support further sustainable research.
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- 2022
24. RESEARCH ON COMPETENCY MODEL OF HEALTH EMERGENCY MANAGEMENT CADRES BASED ON SCL-90 PSYCHOLOGICAL EVALUATION
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Weichun Li
- Subjects
Pharmacology ,Psychiatry and Mental health ,Pharmacology (medical) - Abstract
Background Since entering the 21st century, a series of public health emergencies such as SARS, influenza A and covid-19 in 2019 have occurred continuously, causing serious damage and loss to people's lives and property. In the process of social transformation and economic globalization, the probability of various new public health events is increasing, the number of group unexplained diseases is increasing, and the cross-border and cross-border impact of the virus is rising, which has brought a lot of new challenges to China's health emergency management. Health emergency management cadres are the key groups to deal with public health emergencies. So far, the existing theoretical research results have not established a unified evaluation standard and detailed evaluation index for the post competence of health emergency management cadres, which will not be conducive to the comparison and application of evaluation results. Based on the psychological test results, this study constructs the competency model of health emergency management cadres and compiles the evaluation scale, so as to provide an objective evaluation tool for comprehensively measuring the post competency of health emergency management cadres. Subjects and Methods Competency elements, also known as competency, refer to the potential characteristics that can distinguish outstanding people from ordinary people in work (or organization and Culture). Grounded theory research is a qualitative method, which refines the concept of the research object and the relationship between its elements by encoding the collected data sentence by sentence. The grounded theory (GT) was used to conduct psychological evaluation and behavioral interviews with health emergency management experts to construct the competency element system of health emergency management cadres. Through exploratory factor analysis, the competency model of health emergency management cadres was constructed. The competency evaluation of health emergency management cadres should not only be based on scientific competency elements, but also establish specific quantitative items to test the competency level of this group. According to the competency model of health emergency management cadres, the corresponding Likert five point evaluation scale is compiled in order to provide a management tool for the evaluation of the competency of health emergency management cadres. At the same time, SCL-90 scale was used to measure the psychological state of these cadres. Results The competency model of health emergency management cadres was composed of three competency dimensions: specialization, professional quality and professional ability, and 16 competency dimensions. On this basis, the competency evaluation scale of health emergency management cadres was compiled. The final scale contains 43 items. Conclusion The scale has good reliability, validity and fit. It is a reliable, effective and applicable scale. It can not only be used as a tool to evaluate the post competence of health emergency management cadres, but also provide a scientific basis for the selection, training and self-assessment of health emergency management cadres. In short, we should carry out relevant combination of industry and education according to our own advantages and characteristics. Make clear the goal of motivation by example, and regularly hold activities such as successful model sharing, experience introduction and project display, so as to set a successful example for positive emotions, clarify the specific objectives of the activities, form a strong psychological momentum, stimulate internal potential and help the realization of positive behavior. We should strengthen professional guidance, give full play to the concentration of professionals, high intelligence, professional knowledge in business fields, and give full play to the advantages of talents and intelligence. We can organize experts and scholars to establish a professional bid winning guidance team, give full play to the business projects of experts and scholars in their respective fields, and carry out scientific research on relevant projects. Acknowledgements Fund Project: 1. CAAC safety capability project: research on theoretical system of civil aviation supervision with Chinese characteristics; 2.CAAC educational talent project:(Project No.:MHJY2022018) construction of competency model and assessment scale development for senior civil aviation inspectors; 3.Special fund project of Central Universities basic scientific research business (Project No.: J2021-114): Competency model construction and evaluation scale development of civil aviation health emergency management cadres.
- Published
- 2022
25. Author response for 'SLCO4A1‐AS1 regulates laryngeal squamous cell carcinoma cell phenotypes via the Wnt pathway'
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Linglong Li, Zhongmei He, Dehong Mao, Feng Zhang, Xu Zhang, and Weichun Li
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medicine.anatomical_structure ,Cell ,medicine ,Wnt signaling pathway ,Cancer research ,Biology ,Laryngeal squamous cell carcinoma ,Phenotype - Published
- 2021
26. Notes on the genus Gargela (Lepidoptera: Crambidae), with descriptions of two new species from China
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Weichun Li, Lu-Lan Jie, and Jing-Bo Yang
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Lepidoptera genitalia ,Microlepidoptera ,biology ,Crambidae ,Zoology ,Taxonomy (biology) ,biology.organism_classification ,China ,Crambinae ,Pyraloidea ,Ecology, Evolution, Behavior and Systematics - Abstract
The present paper adds two new species to the genus Gargela Walker, 1864 from China: Gargela polyacantha Li, sp. nov. and G. grandispinata Li, sp. nov. The adults and genital structures of ...
- Published
- 2019
27. Improved Lattice-Based Signcryption in the Standard Model
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Hejun Xuan, Xiaopeng Yang, Hao Cao, and Weichun Li
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General Computer Science ,Computer science ,02 engineering and technology ,Encryption ,Lattice (order) ,Ciphertext ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,Key encapsulation ,ring learning with errors (RLWE) problem ,Quantum computer ,Signcryption ,Computer Science::Cryptography and Security ,lattice ,Cryptographic primitive ,business.industry ,General Engineering ,020206 networking & telecommunications ,020207 software engineering ,ideal short integer solution (ISIS) problem ,encapsulation ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,business ,Algorithm ,lcsh:TK1-9971 ,Learning with errors - Abstract
Signcryption is a basic cryptographic primitive that simultaneously captures the functions of encryption and signature. To realize comprehensive information security against quantum computing attacks, lattice-based signcryption schemes have been successively proposed. However, the performance of signcryption schemes should be improved in the lattice setting. An efficient lattice-based signcryption scheme in the standard model is proposed in this paper. Under the ring learning with errors (RLWE) assumption and the ideal short integer solution (ISIS) assumption, the proposed signcryption scheme achieves indistinguishability against adaptive chosen ciphertext attacks (IND-CCA2) and existential unforgeability under an adaptive chosen-message attack (EUF-ACMA). Our scheme not only reduces the communication and computational overhead but also realizes a new design that combines the partitioning technique with the idea of tag-based key encapsulation. The performance analysis results show that our scheme is more efficient than previous lattice-based signcryption schemes in the standard model.
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- 2019
28. A review of Microchilo (Lepidoptera: Crambidae) in China, including descriptions of two new species
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Weichun Li
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Lepidoptera genitalia ,Subfamily ,LSID ,biology ,Crambidae ,Microchilo ,Genus ,Insect Science ,Key (lock) ,Zoology ,biology.organism_classification ,Crambinae - Abstract
The genus Microchilo of the subfamily Crambinae is reviewed from China. Two species are described as new to science: Microchilo landryi sp. nov. and M. nussi sp. nov. Images of adults and genitalia of the new species are illustrated, and a key of the species known in China is provided. LSID urn:lsid: zoobank.org :pub:74B34A6E-87C3-487B-AD94-1167F1283E74.
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- 2018
29. Immunotherapy-Associated Pancreatic Adverse Events: Current Understanding of Their Mechanism, Diagnosis, and Management
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Le Yang, Ya Liu, Li Zhou, Hao Zhang, Kezhou Li, Weichun Li, Wen Li, and Xubao Liu
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Oncology ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,pancreatitis ,030209 endocrinology & metabolism ,lcsh:RC254-282 ,Targeted therapy ,immune checkpoint inhibitors ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Internal medicine ,medicine ,Endocrine system ,Adverse effect ,Original Research ,pancreatic exocrine insufficiency ,business.industry ,amylase/lipase ,Cancer ,Immunotherapy ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,ICIs associated with diabetes mellitus ,030220 oncology & carcinogenesis ,immune-related adverse events ,Pancreatitis ,Pancreatic injury ,business - Abstract
Immune checkpoint inhibitors (ICIs) such as anti-programmed death-1 (PD-1) and its ligand PD-L1 and anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibodies, are involved in T cell-mediated immune response augmentation and promote anti-tumor immunity. Cancer patients treated with combination of immunotherapy, chemotherapy, radiotherapy, and targeted therapy exhibit superior clinical outcomes and tolerance compared with patients treated with monotherapies. However, immutherapy is associated with several concomitant immune-related adverse events (irAEs). For instance, IrAEs interferes with function of gastrointestinal tract, endocrine, dermatological, nervous system and musculoskeletal systems. ICIs-associated pancreatic injury might causes decrease in endocrine and exocrine pancreatic function, resulting in metabolic and nutritional disorders. Clinicians who administer immune checkpoint inhibitors to cancer patients are diagnosed with hyperglycemia, abdominal pain and steatorrhea. Currently, the precise mechanism of ICIs-associated pancreatic injury has not been fully explored. This paper summarizes incidence, diagnosis, clinical characteristics, potential mechanisms, and treatment management patterns of ICIs-associated pancreatic AEs based on previous studies. In addition, possible management approaches of these adverse effects are presented in this paper. in the findings summarized in this paper lay a basis for management of ICIs-associated pancreatic AEs and expanding future immunotherapy applications.
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- 2021
30. A selective and stable vapochromic system constructed by pillar[5]arene-based host–guest interactions
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You-Ming Zhang, Peng Qin, Tai-Bo Wei, Weichun Li, Yongping Chai, Hao-Hang Yang, Qi Lin, Xiao-Ni Qi, Wen-Juan Qu, Hong Yao, Xing-Xing Zhao, and Bingbing Shi
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Glass sheet ,Materials science ,Process Chemistry and Technology ,General Chemical Engineering ,Phenazine ,Pillar ,engineering.material ,Highly selective ,Combinatorial chemistry ,chemistry.chemical_compound ,chemistry ,Coating ,Color changes ,engineering ,Thin film ,Derivative (chemistry) - Abstract
The development of new strategies for the construction of highly selective and stable vapochromic system is still in great demand. Here, we present a highly selective and stable vapochromic system constructed by pillar[5]arene-based host–guest interactions between a pillar[5]arene (EtP5) and a phenazine derivative. The present material in this work showed specific selective responsiveness to chloroform vapor. The resultant dark orange solid sample was highly stable, which can maintain the color in air for at least two months at room temperature. Moreover, CHCl3 vapor responsive thin film and light-emitting diode (LED) was successfully prepared by coating the EtP5⊃1 complex on a glass sheet and a commercially available UV-LED. This work provided a new approach for the design and construction of selective and stable vapochromic systems with obvious color changes using pillar[5]arene-based host–guest interactions.
- Published
- 2022
31. Impacto da analgesia pós-toracotomia com dexmedetomidina e morfina em imunócitos: estudo randomizado
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Aijun Shan, Pengfei Lei, Weichun Li, Bo Du, Shan Gao, Jin Wang, Fei Shi, and Hao Wang
- Subjects
Adult ,Male ,Intravenous analgesia ,medicine.medical_treatment ,Body weight ,law.invention ,Morfina ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Anesthesiology ,030202 anesthesiology ,law ,Medicine ,Humans ,Linfócitos ,RD78.3-87.3 ,Anesthesia induction ,Thoracotomy ,Dexmedetomidine ,Pain, Postoperative ,Morphine ,business.industry ,Toracotomia ,Analgesia, Patient-Controlled ,General Medicine ,Analgesics, Non-Narcotic ,Middle Aged ,Peripheral blood ,Lymphocyte Subsets ,Analgesics, Opioid ,Killer Cells, Natural ,Dexmedetomidina ,lcsh:Anesthesiology ,Immunocytes ,Anesthesia ,Female ,Analgesia ,business ,medicine.drug - Abstract
Objective This study aimed to investigate the impact of post-thoracotomy analgesia with dexmedetomidine and morphine on immunocytes. Methods A total of 118 patients with post-thoracotomy Patient-Controlled Intravenous Analgesia (PCIA) in our hospital from March 2016 to July 2018 were randomly selected and divided into the Composite (COM) Group (57 patients administered with dexmedetomidine [1.0 µg.kg-1 body weight] and morphine [0.48 mg.kg-1 body weight]) and the Morphine (MOR) group (61 patients administered with morphine [0.48 mg.kg-1]). The values of lymphocyte subsets (CD3+, CD4+, and CD8+) and Natural Killer cells in the peripheral blood of these two groups were detected by FACSCalibur flow cytometry at different time points (before anesthesia induction [T0], immediately after tracheal extubation [T1], 12 hours after surgery [T2], 24 hours after surgery [T3], 48 hours after surgery [T4], 72 hours after surgery [T5], and 7 days after surgery [T6]). The doses of morphine at T3 to T5 and the adverse reactions between the two groups were also recorded and compared. Results The CD3+ level and the CD4+/CD8+ ratio at T2 to T5 and the CD4+ level and NK cells at T3 to T5 were significantly higher in the COM Group than in the MOR Group (p< 0.05). The postoperative morphine dose and the incidence of postoperative itching, nausea, and vomiting were significantly lower in the COM Group than in the MOR Group (p< 0.05). Conclusions Dexmedetomidine combined with morphine for post-thoracotomy PCIA can improve the function of immunocytes, reduce morphine consumption, and reduce the adverse reactions during analgesia induction. Resumo Objetivo Estudar o impacto em linfócitos causado pelo uso da dexmedetomidina associada à morfina para analgesia pós-toracotomia. Método Um total de 118 pacientes utilizando Analgesia Intravenosa Controlada pelo Paciente (AICP) pós-toracotomia em nosso hospital, de março de 2016 a julho de 2018, foram selecionados aleatoriamente e divididos em dois grupos: o Grupo Combinado [COM, 57 pacientes que receberam dexmedetomidina (1,0 µg.kg-1 de peso corpóreo) associada à morfina (0,48 mg.kg-1 de peso corpóreo)] e o Grupo Morfina [MOR, 61 pacientes, que receberam somente morfina (0,48 mg.kg-)]. Os valores dos subconjuntos de linfócitos (CD3+, CD4+ e CD8+) e das células NK no sangue periférico desses dois grupos foram medidos por citometria de fluxo FACSCalibur em diferentes momentos do estudo [antes da indução anestésica (T0), imediatamente após extubação traqueal (T1), 12 horas após a cirurgia (T2), 24 horas após a cirurgia (T3), 48 horas após a cirurgia (T4), 72 horas após a cirurgia (T5) e 7 dias após a cirurgia (T6)]. As doses de morfina do momento T3 ao T5 e as reações adversas entre os dois grupos também foram registradas e comparadas. Resultados O nível de CD3+ e a razão CD4+/CD8+ de T2 a T5, e o nível de CD4+ e as células NK de T3 a T5 do Grupo COM foram significantemente maiores (p< 0,05) quando comparados ao Grupo MOR. A dose de morfina no pós-operatório e a incidência de prurido, náusea e vômito no pós-operatório foram significantemente menores no grupo MOR (p< 0,05). Conclusões Dexmedetomidina combinada com morfina para AICP no período pós-toracotomia pode melhorar a função dos linfócitos, reduzir o consumo de morfina e diminuir reações adversas durante a analgesia.
- Published
- 2020
32. Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution
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Matthieu Dos Santos, Akansha M. Shah, Yichi Zhang, Svetlana Bezprozvannaya, Kenian Chen, Lin Xu, Weichun Lin, John R. McAnally, Rhonda Bassel-Duby, Ning Liu, and Eric N. Olson
- Subjects
Science - Abstract
Abstract Skeletal muscle fibers express distinct gene programs during development and maturation, but the underlying gene regulatory networks that confer stage-specific myofiber properties remain unknown. To decipher these distinctive gene programs and how they respond to neural activity, we generated a combined multi-omic single-nucleus RNA-seq and ATAC-seq atlas of mouse skeletal muscle development at multiple stages of embryonic, fetal, and postnatal life. We found that Myogenin, Klf5, and Tead4 form a transcriptional complex that synergistically activates the expression of muscle genes in developing myofibers. During myofiber maturation, the transcription factor Maf acts as a transcriptional switch to activate the mature fast muscle gene program. In skeletal muscles of mutant mice lacking voltage-gated L-type Ca2+ channels (Cav1.1), Maf expression and myofiber maturation are impaired. These findings provide a transcriptional atlas of muscle development and reveal genetic links between myofiber formation, maturation, and contraction.
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- 2023
- Full Text
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33. A new species of Pseudohampsonella (Lepidoptera: Limacodidae) from Tibet of China
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Weichun Li and Dan Wang
- Subjects
0106 biological sciences ,biology ,Zoology ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Limacodidae ,FAMILY LIMACODIDAE ,Lepidoptera genitalia ,010602 entomology ,Data sequences ,Genus ,Insect Science ,Botany ,Key (lock) ,China - Abstract
A new species of the family Limacodidae, Pseudohampsonella lii sp. nov., is described from Tibet of China based on morphological characters and 658 bp of COI sequence data. It represents a fifth species of the genus. Images of adult and genitalia of the new species, and the key and distribution map of the genus are provided.
- Published
- 2017
34. Iterative Total Least-Squares Algorithm for Joint Detection via the Conjugate Gradient Method
- Author
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Wen Ye, Tongliang Fan, Weichun Li, and Yandong Sun
- Subjects
Computer Networks and Communications ,Computer science ,Iterative method ,020206 networking & telecommunications ,02 engineering and technology ,Derivation of the conjugate gradient method ,Nonlinear conjugate gradient method ,Conjugate gradient method ,0202 electrical engineering, electronic engineering, information engineering ,Conjugate residual method ,020201 artificial intelligence & image processing ,Total least squares ,Gradient descent ,Gradient method ,Algorithm - Published
- 2017
35. Integrative taxonomy reveals the exceptional species diversity of Eudonia (Lepidoptera: Crambidae) in Tibet, China
- Author
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Weichun Li
- Subjects
0106 biological sciences ,0301 basic medicine ,Scopariinae ,Ecology ,Species diversity ,Plant Science ,Biology ,Eudonia ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Lepidoptera genitalia ,03 medical and health sciences ,030104 developmental biology ,Crambidae ,Taxonomy (biology) ,China ,Ecology, Evolution, Behavior and Systematics - Abstract
The genus Eudonia is rarely recorded in Tibet despite having a wide occurrence in the plateau. In the taxonomy of the genus, the morphological characters are insufficient to delimit the closely related congeners due to the subtly interspecific differences and conspicuously intraspecific variability. In this study, the Tibetan species are studied with an integrative approach using molecular data and morphological characters. It is found that the number of Eudonia species in Tibet accounts for about 20% of the total species previously catalogued for the genus in China. Five species are described as new to science: Eudonia galonglaensis Li, sp. nov., E. varians Li, sp. nov., E. triangulata Li, sp. nov., E. angusta Li, sp. nov., and E. bomiensis Li, sp. nov. The potential distribution of Chinese Eudonia is predicted and illustrated using MaxEnt and DIVA-GIS. The results reveal the exceptionally high species diversity of Eudonia in Tibet for the first time, demonstrate that the integrative morphological and molecular approach is highly effective for resolving the difficult-to-distinguish morphologies, and predict the region of China to the south of 35°N and to the east of 95°E as having potentially high Eudonia species diversity. http://www.zoobank.org/urn:lsid:zoobank.org:pub:EA3C5D21-9674-46E4-838D-48D5A098314B
- Published
- 2019
- Full Text
- View/download PDF
36. The genusScoparia(Lepidoptera, Crambidae) from Galongla Snow Mountain of China, with DNA barcoding and descriptions of three new species
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Lulan Jie, Weichun Li, and Dong Liu
- Subjects
0106 biological sciences ,Cytochrome c oxidase subunit I ,010607 zoology ,Species diversity ,Plant Science ,Biology ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,DNA barcoding ,Intraspecific competition ,Lepidoptera genitalia ,Crambidae ,Botany ,Taxonomy (biology) ,Scoparia ,Ecology, Evolution, Behavior and Systematics - Abstract
Four species from Galongla Snow Mountain, southeastern Tibet of China are revealed as members of the genus Scoparia by combining DNA barcoding (658 bp of the mitochondrial gene cytochrome c oxidase subunit I, COI) and morphological characters. Three species are described as new to science: S. varians Li, sp. nov., S. nussi Li, sp. nov. and S. lii Li, sp. nov. The female of S. simplicissima Li is described for the first time. All species are described and illustrated, including the habitat, characters of intraspecific variability and sexual dimorphism. A map showing the localities on the Tibetan Plateau, where more than 40% of Chinese Scoparia species are endemic, is also provided. The results suggest the genus Scoparia has high species diversity on the Tibetan Plateau and may exhibit potential for specific adaptation to high plateau environments.
- Published
- 2016
37. A new species of Lucasioides Kwon (Isopoda: Oniscidea: Agnaridae) from China
- Author
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Weichun Li
- Subjects
Male ,China ,Cephalon ,Arthropoda ,Agnaridae ,Posterior margin ,Isopoda ,medicine ,Animals ,Body Size ,Animalia ,Malacostraca ,Ecology, Evolution, Behavior and Systematics ,Taxonomy ,Trachelipodidae ,biology ,Animal Structures ,Anatomy ,Organ Size ,Biodiversity ,biology.organism_classification ,Lobe ,Checklist ,medicine.anatomical_structure ,Animal Science and Zoology ,Taxonomy (biology) ,Female ,Animal Distribution - Abstract
Lucasioides nudus sp. n. is described from Jiangxi Province, China. The new species can be diagnosed by the cephalon having a well-developed median lobe, the pereonite 1 with acutely postero-lateral corners and sinuous posterior margin of epimeron, the male pleopod 1 endopod without setules, and the bilobed exopod with the outer lobe much shorter and broader than the acute triangular inner lobe.
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- 2017
- Full Text
- View/download PDF
38. Chemotherapeutic Response and Prognosis among Lung Cancer Patients with and without Depression
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Yi Shen, Yanqing Liu, Jue Chen, Weichun Li, Lin Cui, Hao Gu, Yayun Qian, Yaodong Zhu, and Gaoyang Chen
- Subjects
Oncology ,medicine.medical_specialty ,Pathology ,business.industry ,Nausea ,Cancer ,medicine.disease ,chemotherapy ,Regimen ,lung cancer ,Docetaxel ,Internal medicine ,Medicine ,medicine.symptom ,business ,Adverse effect ,Lung cancer ,Survival rate ,Depression (differential diagnoses) ,medicine.drug ,Research Paper - Abstract
Purpose: The current study examined quality of life, progression of disease, and survival rate during chemotherapy in newly diagnosed non-small cell lung cancer (NSCLC) patients with depression (n=48) and without depression (n=78). Further, the study explored the hypothesis that the survival benefit resulted from the chemotherapy of docetaxel and cisplatin (the DC regimen). Patients and Methods: In total, 126 patients with newly diagnosed NSCLC participated in a cross-sectional study of DC chemotherapy integrated with standard oncology care in depression and non-depression groups. The health-related quality of life (HR-QOL) was assessed using the quality of life questionnaire for Chinese cancer patients receiving chemobiotherapy (QLQ-CCC). Depression was self-rated using the Zung Self-Rating Depression Scale (Z-SDS). Both HR-QOL and Z-SDS were completed before the first and after the last cycle of chemotherapy. Association between depression and quality of life, treatment responses, adverse effects and survival rate was considered positive at the significance level of p
- Published
- 2015
39. Experimental Demonstration of a Multicorrugation-Pitch-Modulated (MCPM) DFB Semiconductor Laser Based on Reconstruction-Equivalent-Chirp Technology
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Yuechun Shi, Jun Lu, Yunshan Zhang, Bocang Qiu, Jilin Zheng, Weichun Li, Tingting Zhang, and Xiangfei Chen
- Subjects
lcsh:Applied optics. Photonics ,Distributed feedback laser ,Materials science ,business.industry ,lcsh:TA1501-1820 ,spatial-hole-burning ,sampled grating ,Laser ,DFB semiconductor laser ,Atomic and Molecular Physics, and Optics ,law.invention ,Vertical-cavity surface-emitting laser ,Semiconductor laser theory ,Optics ,law ,Quantum dot laser ,lcsh:QC350-467 ,Optoelectronics ,Semiconductor optical gain ,Laser power scaling ,Electrical and Electronic Engineering ,business ,lcsh:Optics. Light ,Tunable laser - Abstract
A multicorrugation-pitch-modulated (MCPM) distributed-feedback semiconductor laser is experimentally demonstrated for the first time to achieve stable single longitudinal mode (SLM) performance. The MCPM structure was equivalently realized based on a sampled grating using reconstruction equivalent chirp (REC) technology. The proposed REC-MCPM structure can effectively flatten the optical intensity distribution along the laser cavity, leading to the strong suppression in spatial hole burning. In addition, the REC-MCPM grating structures can be readily fabricated using conventional holographic lithography combined with low-cost standard micrometer-level photolithography. A proof-of-principle study both in a simulation and an experiment is presented in this paper. The fabricated 400- $\mu\hbox{m} $ -long REC-MCPM semiconductor laser shows very good SLM performance with SMSRs being more than 42 dB under test conditions of a large injection current range (up to 300 mA) and different ambient temperatures.
- Published
- 2015
40. The genus Eudonia Billberg, 1820 from the Hailuogou Glacier area, China (Lepidoptera: Crambidae)
- Author
-
Weichun Li
- Subjects
geography ,geography.geographical_feature_category ,biology ,Ecology ,Scopariinae ,Glacier ,biology.organism_classification ,Eudonia ,Lepidoptera genitalia ,Crambidae ,Insect Science ,Botany ,Taxonomy (biology) ,China ,Pyraloidea - Abstract
The genus Eudonia Billberg, 1820 from the Hailuogou Glacier area, China is studied for the first time. Four species are recognized including three new to science as follows: E. glaciaria Li, sp. n., E. lii Li, sp. n., E. chuanensis Li, sp. n. and E. hexamera Li et al., 2012. Images of adults and genitalia of the species are provided.
- Published
- 2015
41. SWOFT Analysis of B2C Garment Marketing in China
- Author
-
Weichun Li
- Subjects
Business ,Marketing ,China ,SWOT analysis - Published
- 2017
42. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience
- Author
-
Changnan Wang, Bingying Wang, Taruna Pandey, Yong Long, Jianxiu Zhang, Fiona Oh, Jessica Sima, Ruyin Guo, Yun Liu, Chao Zhang, Shaeri Mukherjee, Michael Bassik, Weichun Lin, Huichao Deng, Goncalo Vale, Jeffrey G. McDonald, Kang Shen, and Dengke K. Ma
- Subjects
Science - Abstract
Environmental temperature changes can alter cell membrane lipid composition but the mechanisms underlying this conserved mechanism are unclear. Here, the authors identify the megaprotein LPD-3 in C. elegans as critical for normal phospholipid distribution and cold resilience.
- Published
- 2022
- Full Text
- View/download PDF
43. Study of the Multiwavelength DFB Semiconductor Laser Array Based on the Reconstruction-Equivalent-Chirp Technique
- Author
-
Yating Zhou, Yuechun Shi, Renjia Guo, Lianyan Li, Tingting Zhang, Simin Li, Weichun Li, Linlin Lu, Jingsi Li, Liu Rui, Tang Song, and Xiangfei Chen
- Subjects
Distributed feedback laser ,Materials science ,business.industry ,Far-infrared laser ,Physics::Optics ,Laser ,Atomic and Molecular Physics, and Optics ,Vertical-cavity surface-emitting laser ,law.invention ,Semiconductor laser theory ,Optics ,law ,Chirp ,Optoelectronics ,Physics::Atomic Physics ,Laser power scaling ,business ,Tunable laser - Abstract
A detailed theoretical analysis of the lasing wavelength precision of the DFB laser array based on a reconstruction-equivalent-chirp (REC) technique is presented. Experimental results of the eight-wavelength DFB laser array with equivalent π phase shift (π-EPS) and four-wavelength DFB laser array with equivalent three shifts are also given. High lasing wavelength precision was obtained. This paper demonstrates that the REC technique is a promising way for fabricating the multiwavelength DFB laser array with low cost and high yield.
- Published
- 2013
44. Review of the genusCalamotrophaZeller (Lepidoptera: Crambidae: Crambinae) from China, with descriptions of four new species
- Author
-
Weichun Li and Houhun Li
- Subjects
Lepidoptera genitalia ,Crambidae ,biology ,Genus ,Botany ,Calamotropha ,Key (lock) ,China ,biology.organism_classification ,Crambinae ,Ecology, Evolution, Behavior and Systematics - Abstract
Four new species of the genus Calamotropha Zeller are described from China: Calamotropha duofurcata sp. nov., Calamotropha abrupta sp. nov., Calamotropha aequilata sp. nov. and Calamotropha unispinea sp. nov. Three species are redescribed: Calamotropha formosella Bleszynski, 1961, Calamotropha josettae Bleszynski, 1961 and Calamotropha melli (Caradja and Meyrick, 1933). Calamotropha latella (Snellen, 1890) is newly recorded for China. Images of adults and illustrations of genitalia of the new species and the redescribed species are provided. A checklist and a key to the known Chinese species are presented, along with a map showing the distribution of these species.
- Published
- 2012
45. High alignment tolerance III-V on Si hybrid integration using a reflective slab waveguide
- Author
-
Yue Liu, Weichun Li, Jia Linghui, Xiaochen Sun, Ning-Ning Feng, Zhian Shao, Fuxin Li, and Huang Ying
- Subjects
Waveguide lasers ,Materials science ,Silicon ,business.industry ,Speed test ,Transmitter ,Physics::Optics ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Laser ,01 natural sciences ,Waveguide (optics) ,law.invention ,010309 optics ,Optics ,chemistry ,Modulation ,law ,0103 physical sciences ,Slab ,Optoelectronics ,0210 nano-technology ,business - Abstract
A III-V on Si hybrid integration is demonstrated by using Si slab waveguides with two parabolic reflective facets to increase the alignment tolerance between flip-chip bonded lasers and modulators. DC and high speed test results of the integrated transmitter are included.
- Published
- 2016
46. Chrysoteuchia ningensis sp. n., a new pyralid moth (Lepidoptera: Crambidae) from China
- Author
-
Dong Liu and Weichun Li
- Subjects
Lepidoptera genitalia ,biology ,Crambidae ,Insect Science ,media_common.quotation_subject ,Phallus (fungus) ,Male genitalia ,Botany ,Insect ,biology.organism_classification ,China ,Chrysoteuchia ,media_common - Abstract
A new species Chrysoteuchia ningensis Li, sp. n. is described from China. The new species is similar to C. pyraustoides and C. shafferi by the phallus produced to a long and thin apical spine in the male genitalia. Images of both adult and genitalia of the new species are provided, along with two topographic maps of China showing the localities where Chrysoteuchia are recorded. Type specimens are deposited in the Insect Museum, Jiangxi Agricultural University, Nanchang, China.
- Published
- 2012
47. Notes on the genus Metaeuchromius Bleszynski (Lepidoptera: Crambidae: Crambinae) from China, with description of two new species
- Author
-
Weichun Li, Matthias Nuss, and Houhun Li
- Subjects
Lepidoptera genitalia ,Crambidae ,biology ,Genus ,Anacanthus ,Botany ,Animal Science and Zoology ,Metaeuchromius ,China ,biology.organism_classification ,Crambinae ,Ecology, Evolution, Behavior and Systematics - Abstract
The genus Metaeuchromius Bleszynski is studied in China, with four species treated in this paper. Metaeuchromius singulispinalis sp. nov. and M. anacanthus sp. nov. are described as new; M. inflatus Schouten, 1997 is newly recorded for China; and the female of M. flavofascialis Park, 1990 is described for the first time. Images of the adults and genitalia are provided, along with keys to all the known species based on male and female genitalia.
- Published
- 2009
48. Two New Species of Roxita Bleszynski (Lepidoptera: Crambidae: Crambinae) from China
- Author
-
Houhun Li and Weichun Li
- Subjects
Lepidoptera genitalia ,biology ,Roxita ,Crambidae ,Genus ,Insect Science ,Botany ,Key (lock) ,China ,biology.organism_classification ,Crambinae ,Ecology, Evolution, Behavior and Systematics - Abstract
Two new species of the genus Roxita Bleszynski are described from China: R. acutispinata sp. nov. and R. capacunca sp. nov. Images of the adults and the genitalia are provided, along with a key of the known world species.
- Published
- 2008
49. China’s environmental policy intensity for 1978–2019
- Author
-
Guoxing Zhang, Yang Gao, Jiexun Li, Bin Su, Zhanglei Chen, and Weichun Lin
- Subjects
Science - Abstract
Measurement(s) China’s environmental policy intensity Technology Type(s) machine learning algorithm
- Published
- 2022
- Full Text
- View/download PDF
50. Sheep Counting Method Based on Multiscale Module Deep Neural Network
- Author
-
Jianming Xu, Weichun Liu, Yang Qin, and Guangrong Xu
- Subjects
Sheep counting ,convolutional neural network ,feature reuse ,Csrnet network ,density estimation ,deep learning ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Due to the uneven distribution and large scale change of sheep in the pasture, it is not conducive to the counting and statistics of sheep in animal husbandry. The traditional target counting algorithm has low counting accuracy in the field of animal husbandry, and there are fewer sheep data sets for research. To solve these problems, the data set of sheep density estimation was established, and a method of grassland sheep number estimation based on multi-scale residual visual information fusion Network (MRVIFNet) was proposed. This method extracts multi-scale features of sheep targets by using multiple parallel hole convolutions with different hole rates, and designs a depth neural network that is more suitable for live counting of sheep, so as to reduce the grid effect caused by hole convolution and better adapt to multi-scale changes of sheep. In the sheep density data set, the method obtained the lowest mean absolute error (MAE) and root mean square error (RMSE). In addition, a convolutional neural network model based on view branch sharing is also studied. Compared with the five popular methods, this method can achieve better performance. It is applied to solve the problem of pedestrian scale change and chaotic distribution in complex scenes; The performance of this method is better than that of comparison method, and the application results in actual scenarios verify the effectiveness of this method.
- Published
- 2022
- Full Text
- View/download PDF
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