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Magnetospheric ultra-low frequency (ULF) waves are known to cause radial diffusion and transport of hundreds-keV to few-MeV electrons in the radiation belts, as the range of drift frequencies of such electrons overlaps with the frequencies of the waves, leading to resonant interactions. Numerous expressions have been derived to quantitatively describe radial diffusion, so that they can be incorporated in global models of radiation belt electrons; however, most expressions of the radial diffusion rates are derived only for equatorially mirroring electrons, and are based on estimates of the power of ULF waves that are obtained either from spacecraft close to the equatorial plane or from the ground. Recent studies using the Van Allen Probes and Arase have shown that the wave power in magnetic fluctuations is significantly enhanced away from the magnetic equator, consistent with models simulating the natural modes of oscillation of magnetospheric field lines. This has significant implications for the estimation of radial diffusion rates, as higher pitch angle electrons will experience considerably higher ULF wave fluctuations than equatorial electrons. In this talk, we present recent results on the distribution of the magnetic field wave power as a function of magnetic latitude in different local time sectors and under different solar and geomagnetic conditions. Furthermore, using analytic functions of wave amplitudes in 3D test particle simulations, we simulate the change in L over time for particles of different pitch angles; this change in L can be translated to novel analytic diffusion coefficients with pitch-angle, L and energy dependence. In this talk we discuss the potential implications for the radial diffusion rates as currently estimated.

Objective: To analyze risk factors associated with the flare of inflammatory markers after drainage of obstruction for patients with obstructive urosepsis(OUs) and evaluate the laboratory tests for early judgement of patients’ outcome.Methods We conducted a retrospective study including patients with OUs who received surgical decompression of obstruction in our center between February 2017and January 2022.All patients were categorized into two groups based on whether inflammatory markers flare or not after relief of obstruction. Analysis of patients’ characteristics, manner of decompression and laboratory tests were performed. Results A total of 81 patients were enrolled in this study and we identified 43 cases(53.9%) with serum leukocytes flare. The only risk factor for the flare of serum leukocytes in multivariate analyses was shock（OR=9.116,95%CI=3.028-27.438,P＜0.001）. The receiver operating characteristic curve of multivariate model showed an area of 0.796，95%CI 0.699-0.893,P＜0.001. Patients with shock were found to flare significantly more frequently when compared to those without shock for neutrophil (NEUT)（OR=6.324,95%CI=2.103-19.011,P＝0.001）and serum creatinine(Scr)（OR=2.714,95%CI=2.022-3.643,P＝0.009. Outcome analysis suggested that decreased Scr acted as a leading indicator for the early remission of sepsis（n=76，93.8%）.Conclusion The flare of leukocytes after drainage of obstruction may reflect the dysregulated migration of neutrophils caused by severe urosepsis rather than the results of decompressed procedure or exacerbated retrograde infection. Decreased serum creatinine may serve as an ideal predictor for the early detection of remission.

Objective: To investigate the outcomes of retrograde flexible ureteroscopy in managing parapelvic renal cysts and speculate the factors affecting therapeutic efficacy. Methods: Thirty-eight patient...

The data fileRBSP_PSDdata_Proton201211_201309_K011.h5 includes the calculated proton PSD for mu = 30, 50 and 80 MeV/G, K=0.11 G1/2REduring November 2012 to September 2013 with L* ranges from 3.5 to 5.5. The data fileRBSP_model_Proton201211_201309_3mu.h5contains the model resultsmu = 30, 50 and 80 MeV/G, K=0.11 G1/2REand the log difference between model and data. Formu = 30MeV/G, it also includes the simulation results runs only with radial diffusion. &nbsp

Background It is proposed a new running suture technique called Needle Adjustment Free (NAF) technique, or PAN suture. The efficiency and the safety were evaluated in laparoscopic partial nephrectomy. Methods This new running suture technique avoids the Needle Adjustment method used in traditional techniques. The new continuous suture technique (11 patients) was compared with the traditional continuous suture method (33 patients) used in both transperitoneal and retroperitoneal laparoscopic partial nephrectomy (LPN) in terms of suture time (ST), warm ischemia time (WIT), blood loss (BL), open conversion rate and post-op discharge time, post-op bleeding, post-op DVT, ΔGFR (affected side, 3 months post-op). Differences were considered significant when P Results ST in the PAN suture group was 30.37 ± 16.39 min, which was significant shorter (P = 0.0011) than in the traditional technique group which was 13.68 ± 3.33 min. WIT in the traditional technique group was 28.73 ± 7.89 min, while in the PAN suture group was 20.64 ± 5.04 min, P = 0.0028. The BL in entirety in the traditional technique group was 141.56 ± 155.23 mL, and in the PAN suture group was 43.18 ± 31.17 mL (P = 0.0017). BL in patients without massive bleeding in the traditional technique group was significantly greater than in the PAN suture group at 101.03 ± 68.73 mL versus 43.18 ± 31.17 mL (P = 0.0008). The open conversion rate was 0 % in both groups. There was no significant difference between the two groups in postoperative discharge time, post-op bleeding, post-op DVT, ΔGFR (affected side, 3 months post-op). Conclusions The NAF running suture technique, or PAN suture, leading to less ST, WIT and BL, which was shown to be more effective and safer than the traditional technique used for LPN. A further expanded research with larger sample size is needed.

BACKGROUND: Increasing evidence has demonstrated aquaporins (AQPs) to be critical players in carcinogenesis. Here, we aimed to explore the role of hydropenia in the progression of bladder cancer (BCa), as well as to assess the expression of AQP1, AQP3, and AQP4 in bladder tissues from hydropenic and N-methyl-N-nitrosourea (MNU)-treated rats. METHODS: An orthotopic BCa model was induced by administering Sprague Dawley rats with MNU. A hydropenic rat model was established by administrating rats with 2/3 of the amount of water given to the control group. At week 8, the rats were sacrificed and their bladder tissues were collected. Then, pathological alterations in the rat bladders were assessed by hematoxylin and eosin staining. The RNA and protein expression levels of AQP1, AQP3, and AQP4 were determined by using qRT-PCR and western blot assays. RESULTS: All of the rats (100%) administrated with MNU developed tumors, of which 5 were large (diameter, 0.5–1.0 cm), 10 were medium (diameter, 0.2–0.5 cm), and 5 were small (diameter

The recent Parker Solar Probe (PSP) observations of type III radio bursts show that the effects of finite background magnetic field can be an important factor in the interpretation of data. In the present paper, the effects of background magnetic field on the plasma emission process, which is believed to be the main emission mechanism for solar coronal and interplanetary type III radio bursts, are investigated by means of the particle-in-cell simulation method. The effects of ambient magnetic field are systematically surveyed by varying the ratio of plasma frequency to electron gyro-frequency. The present study shows that for a sufficiently strong ambient magnetic field, the wave-particle interaction processes lead to a highly field-aligned longitudinal mode excitation and anisotropic electron velocity distribution function, accompanied by a significantly enhanced plasma emission at the second harmonic plasma frequency. For such a case, the polarization of the harmonic emission is almost entirely in the sense of extraordinary mode. On the other hand, for moderate strengths of the ambient magnetic field, the interpretation of the simulation result is less than clear. The underlying nonlinear mode coupling processes indicate that to properly understand and interpret the simulation results require sophisticated analyses involving interactions among magnetized plasma normal modes including the two transverse modes of the magneto-active plasma, namely, extraordinary and ordinary modes, as well as electron-cyclotron-whistler, plasma oscillation, and upper-hybrid modes. At present, a nonlinear theory suitable for quantitatively analyzing such complex mode-coupling processes in magnetized plasmas is incomplete, which calls for further theoretical research, but the present simulation results could provide a guide for future theoretical efforts., Comment: 14 pages, 8 figures. This paper will be submitted to Astrophysical Journal(ApJ)

Background Beforehand transection and suturing (BTS) of the dorsal vascular complex (DVC), a novel technique in non-neurovascular bundle sparing (NVB-sparing) extraperitoneal laparoscopic radical prostatectomy (eLRP), had been proposed; this study aimed to evaluate this technique in clinical laparoscopic procedures. Methods Using this new technique, the DVC was transected and sutured after dissection of the pelvic fascia and before dissection of the prostate, especially before ligation of the bilateral prostatic pedicles. This study retrospectively analyzed the data of 90 non NVB-sparing eLRP patients [traditional technique (n=60) and BTS technique (n=30)]. Results The surgical time in the BTS technique group was 121.73±24.53 min, which was significantly shorter (P=0.0015) than the traditional technique group (144.12±39.68 min). The calculated blood loss in the traditional technique group was 388.45±232.78 mL, and 264.16±130.70 mL in the BTS technique group (P=0.0016). The estimated blood loss in the traditional technique group was 350.34±311.80 mL, which was significantly greater than the BTS technique group (250.33±145.31 mL, P=0.0422). The transfusion rate in the traditional technique group was significantly greater than the BTS technique group (15.00% vs. 0.00%; P=0.0266). The biochemical recurrence rate in traditional technique group was 48.33%, which was higher than in the BTS group (30.00%) (P=0.0465). There was no significant difference between the 2 groups with respect to the pre-operative hemoglobin (Hb) concentration, pre-operative hematocrit (HCT), post-operative Hb concentration, post-operative HCT, ΔHCT, pre-operative blood volume, rectal perforation, open conversion, apical capsule residue, false suture, post-operative bleeding, urinary leakage, re-operation, surgical site infection, post-operative stay, and emission time of urinary incontinence. Conclusions In managing the relationship between the DVC and prostate in patients undergoing non NVB-sparing eLRP, the BTS technique was shown to be more effective and safer than the traditional technique.

ObjectivesTo investigate the outcomes of internal ureteral stent versus ureteroscopy (URS) treatments for pregnant women with urolithiasis.DesignThis is a systematic review and meta-analysis of observational studies that investigated the outcomes of internal ureteral stent and ureteroscopy for pregnancy with urolithiasis. This systematic review have been registered on the PROSPERO website (www.york.ac.uk/inst/crd, registration number: CRD42020195607).Data SourcesRelevant studies published from January 1980 to April 2020 were identified through a systematic literature search in MEDLINE, EMBASE, Web of Science and the Cochrane Library.Data extraction and synthesisAll pregnant women in their all pregnancy stages who were underwent double-J (D-J) stent insertion only or URS operation for lithotripsy/stone extraction/exploration were considered. The number of related participants in study more than 10 were included. Fertility outcome and complications of intervention were extracted as main outcomes, while other data such as operation success rate, stone free rate (SFR), patient characteristics, anaesthetic method, ureteral stone characteristics, detail of interventions were obtained as well. Complications were stratified according to Clavien-Dindo criteria. Two authors independently extracted data and assessed the quality of included studies. Study-specific prevalence rates were pooled using a random-effects model. We applied the Newcastle-Ottawa Scale quality assessment to evaluate the quality of the selected studies.ResultsA total of 25 studies were identified with 131 cases undergoing serial stenting and 789 cases undergoing URS operation. The age range was from 16 to 41, and urolithiasis occurred in the second trimester most. Ultrasound was the most commonly used diagnostic method. The most common site of calculi was distal ureter. The average stone size was between 6-17mm. There were 6 studies investigating D-J stent insertion only, while 23 studies involving URS operation. The most commonly used anesthesia for internal ureteral stent therapy was local anesthesia, and for URS treatments, general anesthesia and spinal anesthesia were widely used. The pooled operation success rate was 97% for D-J stent insertion, and 99% for URS. Serial D-J stenting was an effective methods for treating ureter obstruction and only a few patients passed stone spontaneously. Different common lithotripters were used in URS operations and the pooled SFR was about 91%. For internal ureteral stent therapy; the rate of normal fertility outcome was 99%, but the pooled incidence of complications was about 45%. For the URS treatment group, the rate of normal fertility outcome was 99% as well, and the pooled incidence of complications was about 1%. However, the pooled premature and abortion incidence rate of two group were the same as less than 1%, and the same as this in serious complication incidence rate.ConclusionsBoth ureteroscopy operation and internal ureteral stent were usually used for handing pregnancy with urolithiasis. Two treatments had less side effective on fertility outcome, but internal ureteral stent may cause more complications. Evidence suggests that URS therapy may have a greater advantage for pregnancy with urolithiasis when the conditions permit. As it is proved safe and effective, internal ureteral stent could be considered at emergency condition or preoperative preparations was lack.

Background Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients’ poor prognosis. However, the functions of IMP3 and the underlying mechanisms in prostate cancer still remain unknown. Therefore, the current study was carried out to reveal the role and molecular mechanism of IMP3 in prostate cancer progression. Methods The expression levels of IMP3 in prostate cancer tissues and cells were detected by immunohistochemistry (IHC), western blotting and RT-PCR. CCK-8, clone formation, flow cytometry and in vivo tumor formation assays were used to determine cell growth, clone formation apoptosis and tumorigenesis, respectively. The effect of IMP3 on the expression levels of the key proteins in PI3K/AKT/mTOR signaling pathway, including PIP2, PIP3, p-AKT, AKT, p-mTOR, mTOR, PTEN and BAD activation of was determined by western blotting. IP (Immunoprecipitation) assay was used to evaluate the effects of IMP3 and SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) on the ubiquitination of PTEN protein. Results IMP3 expression level was significantly increased in prostate cancer tissues and cell lines (LNCap, PC3 and DU145) as compared with the paracancerous normal tissues and cells (RWPE-1), respectively. High expression of IMP3 apparently promoted cell viability, tumorigenesis and inhibited cell apoptosis in prostate cancer LNCap, DU145 and PC3 cell lines. In mechanism, IMP3 upregulation significantly increased the phosphorylation levels of AKT and mTOR, and elevated PIP3 expression level, while induced significant reductions in the expression levels of BAD, PTEN and PIP2. And, IMP3 overexpression increased SMURF1 expression, which facilitated PTEN ubiquitination. In addition, SMURF1 overexpression enhanced prostate cancer cell viability and inhibited cell apoptosis. Silence of SMURF1 rescued the enhancements in cell proliferation and tumorigenesis and the inhibition in cell apoptosis rates induced by IMP3 in prostate cancer DU145 and LNCap cells. Conclusion This study reveals that IMP3 is overdressed in prostate cancer, which accelerates the progression of prostate cancer through activating PI3K/AKT/mTOR signaling pathway via increasing SMURF1-mediated PTEN ubiquitination.

To achieve a better understanding of the dominant loss mechanisms for the rapid dropouts of radiation belt electrons, three distinct radiation belt dropout events observed by Van Allen Probes are comprehensively investigated. For each event, observations of the pitch angle distribution of electron fluxes and electromagnetic ion cyclotron (EMIC) waves are analyzed to determine the effects of atmospheric precipitation loss due to pitch angle scattering induced by EMIC waves. Last closed drift shells (LCDS) and magnetopause standoff position are obtained to evaluate the effects of magnetopause shadowing loss. Evolution of electron phase space density (PSD) versus L* profiles and the μ and K (first and second adiabatic invariants) dependence of the electron PSD drops are calculated to further analyze the dominant loss mechanisms at different L*. Our findings suggest that these radiation belt dropouts can be classified into distinct classes in terms of dominant loss mechanisms: magnetopause shadowing dominant, EMIC wave scattering dominant, and combination of both mechanisms. Different from previous understanding, our results show that magnetopause shadowing can deplete electrons at L* 4. Compared to the magnetopause standoff position, it is more reliable to use LCDS to evaluate the impact of magnetopause shadowing. The evolution of electron PSD versus L* profile and the μ, K dependence of electron PSD drops can provide critical and credible clues regarding the mechanisms responsible for electron losses at different L* over the outer radiation belt.

The most significant unknown regarding relativistic electrons in Earth's outer Van Allen radiation belt is the relative contribution of loss, transport, and acceleration processes within the inner magnetosphere. Detangling each individual process is critical to improve the understanding of radiation belt dynamics, but determining a single component is challenging due to sparse measurements in diverse spatial and temporal regimes. However, there are currently an unprecedented number of spacecraft taking measurements that sample different regions of the inner magnetosphere. With the increasing number of varied observational platforms, system dynamics can begin to be unraveled. In this work, we employ in situ measurements during the 13–14 January 2013 enhancement event to isolate transport, loss, and source dynamics in a one-dimensional radial diffusion model. We then validate the results by comparing them to Van Allen Probes and Time History of Events and Macroscale Interactions during Substorms observations, indicating that the three terms have been accurately and individually quantified for the event. Finally, a direct comparison is performed between the model containing event-specific terms and various models containing terms parameterized by geomagnetic index. Models using a simple 3/Kp loss time scale show deviation from the event-specific model of nearly 2 orders of magnitude within 72 h of the enhancement event. However, models using alternative loss time scales closely resemble the event-specific model.

Mechanisms for electron injection, trapping, and loss in the near‐Earth space environment are investigated during the October 2012 “double‐dip” storm using our ring current‐atmosphere interactions model with self‐consistent magnetic field (RAM‐SCB). Pitch angle and energy scattering are included for the first time in RAM‐SCB using L and magnetic local time (MLT)‐dependent event‐specific chorus wave models inferred from NOAA Polar‐orbiting Operational Environmental Satellites (POES) and Van Allen Probes Electric and Magnetic Field Instrument Suite and Integrated Science observations. The dynamics of the source (approximately tens of keV) and seed (approximately hundreds of keV) populations of the radiation belts simulated with RAM‐SCB is compared with Van Allen Probes Magnetic Electron Ion Spectrometer observations in the morning sector and with measurements from NOAA 15 satellite in the predawn and afternoon MLT sectors. We find that although the low‐energy (E< 100 keV) electron fluxes are in good agreement with observations, increasing significantly by magnetospheric convection during both SYM‐H dips while decreasing during the intermediate recovery phase, the injection of high‐energy electrons is underestimated by this mechanism throughout the storm. Local acceleration by chorus waves intensifies the electron fluxes at E≥50 keV considerably, and RAM‐SCB simulations overestimate the observed trapped fluxes by more than an order of magnitude; the precipitating fluxes simulated with RAM‐SCB are weaker, and their temporal and spatial evolutions agree well with POES/Medium Energy Proton and Electron Detectors data., Key Points First RAM‐SCB simulations with 2‐D (MLT‐ and L‐dependent) event‐specific chorus wave models inferred from LEO and RBSP dataThe measured low‐energy trapped and precipitating electron fluxes are well reproduced by magnetospheric convectionLocal acceleration by chorus waves intensifies the electron fluxes at energies E greater than approximately 50 keV and overestimates observations

RPID5180397newnew. Thus, we conduct a statistical study of radiation belt dropouts. If PSD drops by factor >5 within a period less than 8 hours, we call it a dropout event. Based on 4 years of VAP data, we get the dropout distribution as a function of $\mu$ , K, and L* and the relationship with solar wind parameters and geomagnetic parameters. The results show that high L* dropouts cover wider $\mu$ , K range. The low L* dropouts mainly follow the influence regions due to EMIC wave. Few dropouts at low $\mu$ , K due to injection while there are many dropouts with low $\mu$ , high K, which is likely due to EMIC waves. Dropouts occurring without EMIC influence are company with stronger solar wind and magnetic activity.

We used the fluxgate magnetometer data from Combined Release and Radiation Effects Satellite (CRRES) to estimate the power spectral density (PSD) of the compressional component of the geomagnetic field in the ∼1 mHz to ∼8 mHz range. We conclude that magnetic wave power is generally higher in the noon sector for quiet times with no significant difference between the dawn, dusk, and the midnight sectors. However, during high Kp activity, the noon sector is not necessarily dominant anymore. The magnetic PSDs have a very distinct dependence on Kp. In addition, the PSDs appear to have a weak dependence on McIlwain parameter L with power slightly increasing as L increases. The magnetic wave PSDs are used along with the Fei et al. (2006) formulation to compute DLLB[CRRES] as a function of L and Kp. The L dependence of DLLB[CRRES] is systematically studied and is shown to depend on Kp. More significantly, we conclude that DLLEis the dominant term driving radial diffusion, typically exceeding DLLB by 1–2 orders of magnitude.

Relativistic electron flux in the radiation belt can drop by orders of magnitude within the timespan of hours. In this study, we used the drift-diffusion model that includes azimuthal drift and pitch angle diffusion of electrons to simulate low-altitude electron distribution observed by POES/MetOp satellites for rapid radiation belt electron dropout event occurring on May 1, 2013. The event shows fast dropout of MeV energy electrons at L>4 over a few hours, observed by the Van Allen Probes mission. By simulating the electron distributions observed by multiple POES satellites, we resolve the precipitation loss with both high spatial and temporal resolution and a range of energies. We estimate the pitch angle diffusion coefficients as a function of energy, pitch angle, and L-shell, and calculate corresponding electron lifetimes during the event. The simulation results show fast electron precipitation loss at L>4 during the electron dropout, with estimated electron lifetimes on the order of half an hour for MeV energies. The electron loss rate show strong energy dependence with faster loss at higher energies, which suggest that this dropout event is dominated by quick and localized scattering process that prefers higher energy electrons. The improved temporal and spatial resolution of electron precipitation rates provided by multiple low-altitude observations can resolve fast-varying electron loss during rapid electron dropouts (over a few hours), which occur too fast for a single low-altitude satellite. The capability of estimating the fast-varying electron lifetimes during rapid dropout events is an important step in improving radiation belt model accuracy.

To effectively study loss due to hiss-driven precipitation of relativistic electrons in the outer radiation belt, it is useful to isolate this loss by studying a time of relatively quiet geomagnetic activity. We present a case of initial enhancement and slow, steady decay of 700 keV–2 MeV electron populations in the outer radiation belt during an extended quiescent period from ∼15 December 2012 to 13 January 2013. We incorporate particle measurements from a constellation of satellites, including the Colorado Student Space Weather Experiment (CSSWE) CubeSat, the Van Allen Probes twin spacecraft, and Time History of Events and Macroscale Interactions during Substorms (THEMIS), to understand the evolution of the electron populations across pitch angle and energy. Additional data from calculated phase space density, as well as hiss and chorus wave data from Van Allen Probes, help complete the picture of the slow precipitation loss of relativistic electrons during a quiet time. Electron loss to the atmosphere during this event is quantified through use of the Loss Index Method, utilizing CSSWE measurements at low Earth orbit. By comparing these results against equatorial Van Allen Probes electron flux data, we conclude the net precipitation loss of the outer radiation belt content to be greater than 92%, suggesting no significant acceleration during this period, and resulting in faster electron loss rates than have previously been reported.

The DREAM3D diffusion model is applied to Van Allen Probes observations of the fast dropout and strong enhancement of MeV electrons during the October 2012 “double-dip” storm. We show that in order to explain the very different behavior in the two “dips,” diffusion in all three dimensions (energy, pitch angle, and L*) coupled with data-driven, event-specific inputs, and boundary conditions is required. Specifically, we find that outward radial diffusion to the solar wind-driven magnetopause, an event-specific chorus wave model, and a dynamic lower-energy seed population are critical for modeling the dynamics. In contrast, models that include only a subset of processes, use statistical wave amplitudes, or rely on inward radial diffusion of a seed population, perform poorly. The results illustrate the utility of the high resolution, comprehensive set of Van Allen Probes' measurements in studying the balance between source and loss in the radiation belt, a principal goal of the mission.