1. Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans
- Author
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Yue Zhang, Xu-Feng Huang, Wei-Qian Zheng, Mu Yuan, Fan Jin, Ming-Zhu Bai, Jing Liu, and Minhao Hu
- Subjects
medicine.medical_specialty ,Bisphenol A ,endocrine system ,lcsh:Medicine ,Review Article ,Endocrine Disruptors ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Implantation failure ,Phenols ,Internal medicine ,Animals ,Humans ,Medicine ,Endocrine system ,Embryo Implantation ,Benzhydryl compounds ,Benzhydryl Compounds ,General Immunology and Microbiology ,business.industry ,urogenital system ,fungi ,lcsh:R ,Environmental Exposure ,General Medicine ,Environmental exposure ,Triclosan ,Endocrinology ,chemistry ,Clinical evidence ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.
- Published
- 2015