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Introduction: Propofol is a widely used anesthetic and its dose is closely related to aging. Telomere length (TL) is a unique heritable trait, and emerging as a biomarker of aging, health and disease. Telomerase RNA component (TERC) plays an important role in maintaining TL. We proposed a hypothesis that propofol dose in general anesthesia can be predicted by measuring TL before operation, which greatly reduced the risk of anesthesia, especially the elderly. Methods: The association between the propofol dose in anesthesia induction and: TL in the DNA of peripheral blood leukocytes; body weight; sex; difference of the Bispectral Index (BIS) before and after anesthesia induction in patients was evaluated by multivariable linear regression analyses. The mutation at the 5'end or 3'end of TERC was detected. We recruited 100 patients of elective surgery. Results: We found that propofol dose in anesthesia induction was clearly correlated significantly with TL (r = 0.78, p < 0.001), body weight (r = 0.84, p = 0.004), sex (r = 0.83, p= 0.84, p = 0.004), sex (r = 0.83, p = 0.004), and difference of BIS before and after anesthesia induction (r = 0.85, p = 0.029). By comparing the absolute values of standardized regression coefficients (0.58, 0.21, 0.19, and 0.12) of the four variables, it can be seen that TL contributes the most to the propofol dose in anesthesia induction. However, the mutation at the 5' end or 3' end of TERC was not found. Conclusions: These findings provide preliminary evidence that the propofol dose in anesthesia induction was clearly correlated with genetically determined TL. TL may be a promising predictor of the propofol dose, which is beneficial to improve the safety of anesthesia and reduce perioperative complications.

This study investigated the correlation between periprostatic fat thickness (PPFT) measured on magnetic resonance imaging and lower urinary tract symptoms, erectile function, and benign prostatic hyperplasia (BPH) progression. A total of 286 treatment-naive men diagnosed with BPH in our department between March 2017 and February 2019 were included. Patients were divided into two groups according to the median value of PPFT: high (PPFT >4.35 mm) PPFT group and low (PPFT

The flame-retardant high temperature vulcanized (HTV) silicone rubber was prepared with the addition of Al(OH)3, Mg(OH)2, nitrogen containing flame-retardant filler and phosphorus-nitrogen containing flame-retardant filler, respectively. The effects of the four halogen-free flame retardant fillers on the flame retardancy, mechanical properties, curing characteristics and thermal stability of the rubber were investigated by TGA. The flame retardant mechanism of HTV silicone rubber with the four above-mentioned fillers was also studied. Results show that when the vertical flame retardant properties of all the rubbers meet grade FV-0, the vertical combustion time of the flame-retardant HTV silicone rubber modified by phosphorus-nitrogen containing flame-retardant filler was the shortest, the tensile strength, elongation at break and tear strength were 6. 43 MPa, 408% and 16. 5 kN/m, respectively. The oxygen index of the flame-retardant HTV silicone rubber modified by Al(OH)3 was 45%, higher than the others. Among the four kinds of the flame-retardent HTV silicone rubber, the silicone rubber modified by nitrogen containing flame-retardant filler has the lowest curing speed. TGA results indicate that the flame-retardant HTV silicone rubber modified by Mg (OH)2 has good thermal aging stability. [ABSTRACT FROM AUTHOR]