Search

In our work, the inclusion ability and binding pattern of flavonoids (catechin, iso‐liquiritigenin, luteolin, puerarin, rutin, and curcumin) with β‐cyclodextrin (β‐CD) and curcumin (CUR) with CDs (α‐CD, β‐CD, γ‐CD, dimethyl‐β‐CD, Hydroxypropyl‐β‐CD, and glucosyl‐β‐CD) were studied by molecular docking. The results showed that CUR among the six flavonoids was more likely to form stable inclusion complexes with β‐CD, and the HP‐β‐CD is the most suitable for CUR inclusion among the 6 types of CD. Phase solubility studies showed that CUR with β‐CD or HP‐β‐CD, respectively, could form stable inclusion complexes in a stoichiometric ratio of 1 : 1. The CUR/β‐CD and CUR/HP‐β‐CD inclusion complexes (ICs) were prepared by freeze‐drying method. The successful preparation of IC was confirmed by SEM images, FT‐IR spectra, and TG‐DSC. The results of in vitro release showed that the release of CUR from IC prepared with β‐CD or HP‐β‐CD could be improved significantly, and the release effect of HP‐β‐CD was better than that of β‐CD. The inclusion with CD could be used to improve the solubility and bioavailability of CUR. [ABSTRACT FROM AUTHOR]

With the rapid development and wide application of the digital media technology,the information security problem is becoming more and more highly attention.Because of the various kinds of medias,previous research works have focused on a specific digital media from,such as text,image,audio and video.As a fact that all the objects were expressed in digital forms under the environment of computer and network,a unified form for all kinds of digital media under the complex number base system was proposed.The algorithm of the digital media signal and the complex number intercom version were given,so the relationship among the digital media could be converted to the corresponding geometric relationship on the complex plane.In the experiments,the proposed method was applied to the application of the digital media information hiding.