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36 results on '"Wei, Zhubo"'

1. The evolution of lung adenocarcinoma precursors is associated with chromosomal instability and transition from innate to adaptive immune response/evasion

Author

Zhang, Jianjun, primary, Hu, Xin, additional, Zhu, Bo, additional, Vokes, Natalie, additional, Fukuoka, Junya, additional, Alvarez, Frank Rojas, additional, Heeke, Simon, additional, Moreira, Andre, additional, Solis, Luisa, additional, Haymaker, Cara, additional, Velcheti, Vamsidhar, additional, Sterman, Daniel, additional, Pass, Harvey, additional, Cheng, Chao, additional, Lee, Jack, additional, Zhang, Jianhua, additional, Wei, Zhubo, additional, Wu, Jia, additional, Li, Xiuning, additional, Ostrin, Edwin, additional, Toumazis, Iakovos, additional, Gibbons, Don, additional, Su, Dan, additional, Antonoff, Mara, additional, Gerber, David, additional, Li, Chenyang, additional, Kadara, Humam, additional, Wang, Linghua, additional, Davis, Mark, additional, Heymach, John, additional, Hanash, Samir, additional, Wistuba, Ignacio, additional, Dubinett, Steven, additional, Alexandrov, Ludmil, additional, Lippman, Scott, additional, Spira, Avrum, additional, Futreal, Andrew, additional, and Reuben, Alexandre, additional

Published
2024
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3. A recellularized human colon model identifies cancer driver genes

Author

Chen, Huanhuan Joyce, Wei, Zhubo, Sun, Jian, Bhattacharya, Asmita, Savage, David J, Serda, Rita, Mackeyev, Yuri, Curley, Steven A, Bu, Pengcheng, Wang, Lihua, Chen, Shuibing, Cohen-Gould, Leona, Huang, Emina, Shen, Xiling, Lipkin, Steven M, Copeland, Neal G, Jenkins, Nancy A, and Shuler, Michael L

Published
2016

7. S. Table 2 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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8. S Table 5 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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9. S Table 1 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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10. Supplementary Data from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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11. Data from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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12. cohort_primary from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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13. S Table 4 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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14. S Table 3 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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22. Sleeping Beauty transposon mutagenesis identifies genes driving the initiation and metastasis of uterine leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, additional, Tien, Jean C, additional, Newberg, Justin Y, additional, Kodama, Takahiro, additional, Wei, Zhubo, additional, Rangel, Roberto, additional, Yoshihara, Kosuke, additional, Kuruma, Airi, additional, Nakae, Aya, additional, Hashimoto, Kae, additional, Sawada, Kenjiro, additional, Kimura, Tadashi, additional, Jenkins, Nancy A, additional, and Copeland, Neal G, additional

Published
2021
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35. The evolution of lung adenocarcinoma precursors is associated with chromosomal instability and transition from innate to adaptive immune response/evasion.

Author

Hu X, Zhu B, Vokes N, Fujimoto J, Rojas Alvarez FR, Heeke S, Moreira AL, Solis LM, Haymaker C, Velcheti V, Sterman DH, Pass HI, Cheng C, Lee JJ, Zhang J, Wei Z, Wu J, Le X, Ostrin E, Toumazis I, Gibbons D, Su D, Fukuoka J, Antonoff MB, Gerber DE, Li C, Kadara H, Wang L, Davis M, Heymach JV, Hannash S, Wistuba I, Dubinett S, Alexandrov L, Lippman S, Spira A, Futreal AP, Reuben A, and Zhang J

Abstract

Studying lung adenocarcinoma (LUAD) early carcinogenesis is challenging, primarily due to the lack of LUAD precursors specimens. We amassed multi-omics data from 213 LUAD and LUAD precursors to identify molecular features underlying LUAD precancer evolution. We observed progressively increasing mutations, chromosomal aberrations, whole genome doubling and genomic instability from precancer to invasive LUAD, indicating aggravating chromosomal instability (CIN). Telomere shortening, a crucial genomic alteration linked to CIN, emerged at precancer stage. Moreover, later-stage lesions demonstrated increasing cancer stemness and decreasing alveolar identity, suggesting epithelial de-differentiation during early LUAD carcinogenesis. The innate immune cells progressively diminished from precancer to invasive LUAD, concomitant with a gradual recruitment of adaptive immune cells (except CD8 + and gamma-delta T cells that decreased in later stages) and upregulation of numerous immune checkpoints, suggesting LUAD precancer evolution is associated with a shift from innate to adaptive immune response and immune evasion mediated by various mechanisms., Competing Interests: J.J.Z. reports research funding from Merck, Johnson and Johnson, Novartis, Summit, Hengenix and consultant fees from BMS, Johnson and Johnson, AstraZeneca, Geneplus, OrigMed, Innovent, Varian, Catalyst outside the submitted work. I.I.W reports Honoraria from Genentech/Roche, Bayer, Bristol-Myers Squibb, Astra Zeneca/Medimmune, Pfizer, HTG Molecular, Asuragen, Merck, GlaxoSmithKline, Guardant Health, Oncocyte, Flame, and MSD; Research support from Genentech, Oncoplex, HTG Molecular, DepArray, Merck, Bristol-Myers Squibb, Medimmune, Adaptive, Adapt immune, EMD Serono, Pfizer, Takeda, Amgen, Karus, Johnson & Johnson, Bayer, Iovance, 4D, Novartis, and Akoya. J.V.H. reports honorariums from AstraZeneca, Boehringer-Ingelheim, Catalyst, Genentech, GlaxoSmithKline, Guardant Health, Foundation medicine, Hengrui Therapeutics, Eli Lilly, Novartis, Spectrum, EMD Serono, Sanofi, Takeda, Mirati Therapeutics, BMS, BrightPath Biotherapeutics, Janssen Global Services, Nexus Health Systems, EMD Serono, Pneuma Respiratory, Kairos Venture Investments, Roche and Leads Biolabs. D.E.G. reports research funding from Astra-Zeneca, BerGenBio, Karyopharm, and Novocure; stock ownership in Gilead; consultant/advisory fees from Abbvie, Astra-Zeneca, Catalyst Pharmaceuticals, Daiichi-Sankyo, Elevation Oncology, Janssen Scientific Affairs, LLC, Jazz Pharmaceuticals, Regeneron Pharmaceuticals, and Sanofi; and serving as co-founder and chief scientific officer of OncoSeer Diagnostics, Inc. S.H. reports consulting fees from Guardant Health and AstraZeneca. S.M.D serves on the Scientific Advisory Boards for Early Diagnostics Inc. and LungLife AI, Inc. and has received research funding from Johnson & Johnson Lung Cancer Initiative and Novartis. The other authors declare no competing interests.

Published
2024
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36. Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis.

Author

Chao WT, Ashcroft F, Daquinag AC, Vadakkan T, Wei Z, Zhang P, Dickinson ME, and Kunz J

Subjects
Adaptor Proteins, Signal Transducing genetics, Adaptor Proteins, Signal Transducing metabolism, Animals, Apoptosis Regulatory Proteins, Cell Adhesion physiology, Cell Line, Cell Movement physiology, Clathrin metabolism, Cytoskeletal Proteins genetics, Cytoskeletal Proteins metabolism, Dynamin II genetics, Dynamin II metabolism, Focal Adhesion Protein-Tyrosine Kinases genetics, Focal Adhesion Protein-Tyrosine Kinases metabolism, Glycoproteins genetics, Glycoproteins metabolism, Humans, Isoenzymes genetics, Isoenzymes metabolism, Phosphatidylinositol 4,5-Diphosphate metabolism, Phosphotransferases (Alcohol Group Acceptor) genetics, RNA Interference, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins metabolism, Tumor Suppressor Proteins, Zyxin, Endocytosis physiology, Focal Adhesions metabolism, Integrin beta1 metabolism, Phosphotransferases (Alcohol Group Acceptor) metabolism
Abstract

Cell migration requires the regulated disassembly of focal adhesions, but the underlying mechanisms remain poorly defined. We have previously shown that focal adhesion disassembly requires the dynamin 2- and clathrin-dependent endocytosis of ligand-activated beta1 integrins. Here, we identify type I phosphatidylinositol phosphate kinase beta (PIPKIbeta), an enzyme that generates phosphatidylinositol-4,5-bisphosphate (PI4,5P(2)), as a key regulator of this process. We found that knockdown of PIPKIbeta by RNA interference blocks the internalization of active beta1 integrins and impairs focal adhesion turnover and cell migration. These defects are caused by the failure to target the endocytic machinery, including clathrin adaptors and dynamin 2, to focal adhesion sites. As a consequence, depletion of PIPKIbeta blocks clathrin assembly at adhesion plaques and prevents complex formation between dynamin 2 and focal adhesion kinase (FAK), a critical step in focal adhesion turnover. Together, our findings identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates integrin endocytosis at adhesion sites to control cell migration.

Published
2010
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