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Background: The common and major pathological change in ischemic stroke is atherosclerosis in the artery. Tumor necrosis factor-a (TNF-a)is closely related to the pathogenesis of atherosclerosis. The aim of our study was to investigate whetherTNF-agene variants (-238G/A and -308G/A) are associated with ischemic stroke.Methods: A total of 619 ischemic stroke patients and 612 controls were recruited to estimate the frequencies of twoTNF-a(-238G/A and -308G/A) single nucleotide polymorphisms using a Sequenom MassARRAY time-of-flight mass spectrometer. The association betweenTNF-agene polymorphisms and ischemic stroke risk was evaluated by computing the odds ratio (OR) and 95% Confidence Interval with multivariate unconditional logistic regression analyses.Results: The OR results indicated that no significant associations were found betweenTNF-agene (-238G/A and -308G/A) polymorphisms and the risk of ischemic stroke using five genetic models, including the allele model (A vs. G), co-dominant model 1 (GA vs. GG), co-dominant model 2 (AA vs. GG), the dominant model (AA+GA vs. GG), and the recessive model (GG+GA vs. AA).Conclusions: TheTNF-a(-238G/A and -308G/A) gene polymorphisms may not be a susceptible predictor of ischemic stroke in Chinese populations. [ABSTRACT FROM PUBLISHER]