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Your search keyword '"Wei, Chih-Ming"' showing total 10 results
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10 results on '"Wei, Chih-Ming"'

9. Highly Sensitive Emission Sensor Based on Surface Plasmon Enhanced Energy Transfer between Gold Nanoclusters and Silver Nanoparticles

Author

Chen, Chih-Wei, Wang, Chun-Hsiung, Wei, Chih-Ming, Hsieh, Chun-Yi, Chen, Yung-Ting, Chen, Yang-Fang, Lai, Chih-Wei, Liu, Chien-Liang, Hsieh, Cheng-Chih, and Chou, Pi-Tai

Abstract

In the study of interaction between emissive gold nanoclusters and silver nanoparticles, we explored that the emission of gold nanoclusters is very sensitive to the presence of silver nanoparticles. Quite remarkably, the quenching ratio can reach more than several hundred times. We demonstrate that the underlying mechanism can be attributed to the surface energy transfer with the quenching efficiency following the expression χ = 1/[1 + (d/d0)4], where dis the distance between gold nanoclusters and silver nanoparticles, and d0is the characteristic length of energy transfer. This highly sensitive behavior in the composite consisting of relatively nontoxic gold nanoclusters and silver nanoparticles may find a powerful potential in developing biomedical applications, such as biosensors and drugs delivery.

Published
2010
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10. Frequency and phenotypic analysis of CD4+CD25+ regulatory T cells in children with juvenile idiopathic arthritis.

Author

Wei CM, Lee JH, Wang LC, Yang YH, Chang LY, and Chiang BL

Subjects
Adolescent, Adult, Antigens, CD immunology, Arthritis, Juvenile drug therapy, Arthritis, Juvenile pathology, CTLA-4 Antigen, Case-Control Studies, Child, Child, Preschool, Female, Flow Cytometry, Follow-Up Studies, Humans, Male, Phenotype, T-Lymphocytes, Regulatory cytology, Taiwan, Arthritis, Juvenile immunology, CD4 Antigens immunology, Interleukin-2 Receptor alpha Subunit immunology, T-Lymphocytes, Regulatory immunology
Abstract

Background and Purpose: The aim of this study was to investigate the frequency of CD4(+)CD25(+) regulatory T cells and their phenotypic expression in peripheral blood of children with active and non-active juvenile idiopathic arthritis (JIA) and healthy controls, to determine if their frequency or phenotypic expression is involved in the immunoregulation of this disease., Methods: From October 2004 to October 2005, 55 JIA patients and 55 age- and gender-matched healthy controls were enrolled in the study at National Taiwan University Hospital. Flow cytometry was used to determine the frequency of CD4(+)CD25(+) and CD4(+)CD25(hi) in CD4(+) T cells and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) expression on CD4(+)CD25(+) by tricolor staining. Basic profiles, medication history, clinical symptoms and laboratory data were obtained by chart review and outpatient department interviews., Results: There was no significant difference in expression of CD4(+)CD25(+) T cells between patients with inactive JIA and normal controls (13.74+/-3.25% vs 12.85+/-3.68%, p>0.05). The expression of CD4(+)CD25(hi) T cells was significantly lower in inactive JIA patients than in normal controls (1.89+/-1.01% vs 2.76+/-1.28%, p<0.01). The expression of CTLA-4 on CD4(+)CD25(+) T cells was also significantly lower in inactive JIA patients compared with controls (4.37+/-2.02% vs 6.33+/-2.57%, p<0.001)., Conclusion: We speculate that a decreased frequency of CD4(+)CD25(hi) regulatory T cells and lower level of CTLA-4 expression on CD4(+)CD25(+) regulatory T cells might play a role in the immunoregulation of JIA.

Published
2008

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