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348 results on '"Wei, Chenchen"'

21. The pseudogene DUXAP10 contributes to gefitinib resistance in NSCLC by repressing OAS2 expression

Author

Ren Shengnan, Zhu Ya, Wang Siying, Zhang Qinqiu, Zhang Niu, Zou Xiaoteng, Wei Chenchen, and Wang Zhaoxia

Subjects
NSCLC, gefitinib resistance, DUXAP10, EZH2, OAS2, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI),is the currently recommended first-line therapy for advanced EGFR-mutant lung cancer, and understanding the mechanism of resistance is the key to formulating therapeutic strategies for EGFR-TKIs. In this study, we evaluate the expression patterns and potential biological functions of the pseudogene DUXAP10 in gefitinib resistance. We find that pseudogene DUXAP10 expression is significantly upregulated in NSCLC gefitinib-resistant cells and tissues. Gain and loss of function assays reveal that knockdown of DUXAP10 by siRNA reverses gefitinib resistance both in vitro and in vivo. Furthermore, DUXAP10 interacts with the histone methyltransferase enhancer of zeste homolog 2 (EZH2) to repress the expression of 2′,5′-oligoadenylate synthetase (OAS2). Overall, our study highlights the pivotal role of DUXAP10 in gefitinib resistance, and the DUXAP10/EZH2/OAS2 axis might be a promising therapeutic target to overcome acquired gefitinib resistance in NSCLC.

Published
2022
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32. Determinants and Pathways of Nitrous Oxide Emissions from Soil Irrigated with Reclaimed Water.

Author

Chi, Yanbing, Wei, Chenchen, Yang, Peiling, and Ma, Ning

Subjects
*GREENHOUSE gases, *IRRIGATED soils, *NITRITE reductase, *SOIL chemistry, *AMMONIA-oxidizing archaebacteria, *DENITRIFICATION
Abstract

Reclaimed water (RW), as a reliable and renewable secondary water source, has become a crucial strategy for many countries to supplement agricultural water usage and alleviate water scarcity. However, despite the increasing use of RW, there has been limited research on the factors affecting soil nitrous oxide ( N 2 O ) emissions under RW irrigation. Understanding these factors is essential for guiding RW irrigation practices and controlling greenhouse gas emissions. This research, conducted from 2014 to 2015, includes field experiments designed to systematically assess the effects of soil chemistry properties and temperature on soil N 2 O emissions under RW irrigation. Subsequent to these field studies, soil samples were collected for 15N isotope trials to examine the impact of RW on the soil N 2 O production process, including autotrophic nitrification, heterotrophic nitrification, and denitrification. The results showed that RW irrigation influenced soil N 2 O emissions by affecting soil pH, but not through changes in soil total nitrogen (TN) or soil organic carbon (SOC) content. Moreover, compared to groundwater (UW) irrigation, RW irrigation significantly reduced the temperature sensitivity of soil N 2 O emissions. The 15N isotope labeling trial indicated that autotrophic nitrification was the primary pathway for soil N 2 O production under RW irrigation, contributing 60.46%—significantly higher than that observed with UW irrigation. Primary treated sewage (PW) significantly increased soil N 2 O emissions through the heterotrophic nitrification process compared to RW, with contributions rising from 11.31% to 13.23%. Additionally, RW, compared to UW, significantly increased the copy numbers of soil nitrification genes (ammonia-oxidizing archaea [AOA-amoA]) and denitrification genes (nitrite reductase [nirK and nirS]). Therefore, it is important to appropriately control the nitrification process and balance soil pH to manage soil N 2 O emissions under RW irrigation. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Stroke in China: advances and challenges in epidemiology, prevention, and management

Author

Wu, Simiao, Wu, Bo, Liu, Ming, Chen, Zhengming, Wang, Wenzhi, Anderson, Craig S, Sandercock, Peter, Wang, Yongjun, Huang, Yining, Cui, Liying, Pu, Chuanqiang, Jia, Jianping, Zhang, Tong, Liu, Xinfeng, Zhang, Suming, Xie, Peng, Fan, Dongsheng, Ji, Xunming, Wong, Ka-Sing Lawrence, Wang, Longde, Wei, Chenchen, Wang, Yanan, Cheng, Yajun, Liu, Yunhai, Li, Xin, Dong, Qiang, Zeng, Jinsheng, Peng, Bin, Xu, Yun, Yang, Yi, Wang, Yilong, Zhao, Gang, Wang, Wei, Xu, Yuming, Yang, Qingwu, He, Zhiyi, Wang, Shaoshi, You, Chao, Gao, Ying, Zhou, Dong, He, Li, Li, Zixiao, Yang, Jie, Lei, Chunyan, Zhao, Yuhua, Liu, Junfeng, Zhang, Shuting, Tao, Wendan, Hao, Zilong, Wang, Deren, and Zhang, Shihong

Published
2019
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