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1. The genomic and evolutionary landscapes of anaplastic thyroid carcinoma

Author

Zeng, Peter YF, Prokopec, Stephenie D, Lai, Stephen Y, Pinto, Nicole, Chan-Seng-Yue, Michelle A, Clifton-Bligh, Roderick, Williams, Michelle D, Howlett, Christopher J, Plantinga, Paul, Cecchini, Matthew J, Lam, Alfred K, Siddiqui, Iram, Wang, Jianxin, Sun, Ren X, Watson, John D, Korah, Reju, Carling, Tobias, Agrawal, Nishant, Cipriani, Nicole, Ball, Douglas, Nelkin, Barry, Rooper, Lisa M, Bishop, Justin A, Garnis, Cathie, Berean, Ken, Nicolson, Norman G, Weinberger, Paul, Henderson, Ying C, Lalansingh, Christopher M, Tian, Mao, Yamaguchi, Takafumi N, Livingstone, Julie, Salcedo, Adriana, Patel, Krupal, Vizeacoumar, Frederick, Datti, Alessandro, Xi, Liu, Nikiforov, Yuri E, Smallridge, Robert, Copland, John A, Marlow, Laura A, Hyrcza, Martin D, Delbridge, Leigh, Sidhu, Stan, Sywak, Mark, Robinson, Bruce, Fung, Kevin, Ghasemi, Farhad, Kwan, Keith, MacNeil, S Danielle, Mendez, Adrian, Palma, David A, Khan, Mohammed I, Shaikh, Mushfiq, Ruicci, Kara M, Wehrli, Bret, Winquist, Eric, Yoo, John, Mymryk, Joe S, Rocco, James W, Wheeler, David, Scherer, Steve, Giordano, Thomas J, Barrett, John W, Faquin, William C, Gill, Anthony J, Clayman, Gary, Boutros, Paul C, and Nichols, Anthony C

Subjects
Biological Sciences, Genetics, Human Genome, Cancer, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Humans, Thyroid Carcinoma, Anaplastic, Thyroid Neoplasms, Mutation, Adenocarcinoma, Genomics, CP: Cancer, CP: Genomics, anaplastic thyroid cancer, cancer progression, genomics, tumour evolution, tumour heterogeneity, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes. Further, different cancer driver genes are mutated in anaplastic and differentiated thyroid carcinomas, even those arising in a single patient. Finally, we unambiguously demonstrate that anaplastic thyroid carcinomas share a genomic origin with co-occurring differentiated carcinomas and emerge from a common malignant field through acquisition of characteristic clonal driver mutations.

Published
2024

2. Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer

Author

Torlakovic, Emina E., Baniak, Nick, Barnes, Penny J., Chancey, Keith, Chen, Liam, Cheung, Carol, Clairefond, Sylvie, Cutz, Jean-Claude, Faragalla, Hala, Gravel, Denis H., Dakin Hache, Kelly, Iyengar, Pratibha, Komel, Michael, Kos, Zuzana, Lacroix-Triki, Magali, Marolt, Monna J., Mrkonjic, Miralem, Mulligan, Anna Marie, Nofech-Mozes, Sharon, Park, Paul C., Plotkin, Anna, Raphael, Simon, Rees, Henrike, Seno, H Rommel, Thai, Duc-Vinh, Troxell, Megan L., Varma, Sonal, Wang, Gang, Wang, Tao, Wehrli, Bret, and Bigras, Gilbert

Published
2024
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3. Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report

Author

Wehrli Bret M, Bella Anthony J, Parfitt Jeremy R, and Izawa Jonathan I

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms of uncertain malignant potential, which have in common the co-expression of muscle and melanocytic immunohistochemical markers. Case presentation A 48-year-old man presented with dysuria, passage of urinary sediment and lower abdominal discomfort. A three centimeter mass was identified by cystoscopy in the posterior midline of the bladder. Computerized tomography suggested an enterovesical fistula. The patient underwent laparotomy, partial cystectomy and partial small bowel resection. Pathological examination revealed PEComa of the bladder. The patient underwent adjuvant interferon-α immunotherapy. Subsequent follow-up procedures, including cystoscopy and imaging, have not revealed evidence of recurrence. The patient is clinically free of disease 48 months after surgery. Conclusion This case represents the second documented PEComa of bladder and demonstrates that adjuvant therapies, including anti-angiogenic and immunotherapy, may be considered for patients with locally advanced or metastatic genitourinary PEComa.

Published
2006
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4. Sentinel node biopsy as an adjunct to limb salvage surgery for epithelioid sarcoma of the hand

Author

Hammond Alex, Wehrli Bret, Tse Raymond, Seal Alex, and Temple Claire LF

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Epithelioid sarcomas of the hand are rare, high-grade tumors with a propensity for regional lymphatic spread approaching 40%. Case presentation A 54-year-old male with an epithelioid sarcoma of the palm was treated with neoadjuvant radiation, wide excision, and two-stage reconstruction. Sentinel lymph node biopsy was used to stage the patient's axilla. Sentinel node biopsy results were negative. The patient has remained free of local, regional and distant disease for the follow-up time of 16 months. Conclusion The rarity of this tumor makes definitive conclusions difficult but SLN biopsy appears to be a useful adjunct in the treatment of these sarcomas.

Published
2005
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5. Ectomesenchymal Chondromyxoid Tumor

Author

Dickson, Brendan C, Antonescu, Cristina R, Argyris, Prokopios P, Bilodeau, Elizabeth A, Bullock, Martin J, Freedman, Paul D, Gnepp, Douglas R, Jordan, Richard C, Koutlas, Ioannis G, Lee, Cheng-Han, Leong, Iona, Merzianu, Mihai, Purgina, Bibianna M, Thompson, Lester DR, Wehrli, Bret, Wright, John M, Swanson, David, Zhang, Lei, and Bishop, Justin A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Genetics, Human Genome, Cancer, Aetiology, 2.1 Biological and endogenous factors, Actins, Adolescent, Adult, Biomarkers, Tumor, DNA-Binding Proteins, Desmin, Female, Gene Fusion, Genetic Predisposition to Disease, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Keratins, Male, Middle Aged, Neoplasms, Connective and Soft Tissue, Phenotype, Retrospective Studies, S100 Proteins, Sequence Analysis, RNA, Tongue Neoplasms, Transcription Factors, Young Adult, ectomesenchymal chondromyxoid tumor, tongue, gene rearrangement, RREB1, MKL2, EWSR1, CREM, Pathology, Clinical sciences
Abstract

Ectomesenchymal chondromyxoid tumor is a rare and benign neoplasm with a predilection for the anterior dorsal tongue. Despite morphologic heterogeneity, most cases are characterized by a proliferation of bland spindle cells with a distinctive reticular growth pattern and myxoid stroma. The immunophenotype of these neoplasms is likewise variable; most cases express glial fibrillary acid protein and S100 protein, with inconsistent reports of keratin and myoid marker expression. The molecular pathogenesis is poorly understood; however, a subset of cases has been reported to harbor EWSR1 gene rearrangement. Following identification of an RREB1-MKL2 fusion gene by RNA Sequencing in an index patient, a retrospective review of additional cases of ectomesenchymal chondromyxoid tumors was performed to better characterize the clinical, immunohistochemical, and molecular attributes of this neoplasm. A total of 21 cases were included in this series. A marked predisposition for the dorsal tongue was confirmed. Most cases conformed to prior morphologic descriptions; however, hypercellularity, hyalinized stroma, and necrosis were rare attributes not previously emphasized. The neoplastic cells frequently coexpressed glial fibrillary acid protein, S100 protein, keratin, smooth muscle actin, and/or desmin; a single case was found to contain significant myogenin expression. An RREB1-MKL2 fusion product was identified in 19 tumors (90%), a single tumor (5%) had an EWSR1-CREM fusion product, and the remaining case lacked any known fusion gene by RNA Sequencing. The latter 2 cases subtly differed morphologically from many in the cohort. This series illustrates that recurrent RREB1-MKL2 fusions occur in most, perhaps all, cases of ectomesenchymal chondromyxoid tumor.

Published
2018

8. Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial

Author

Nichols, Anthony C, Theurer, Julie, Prisman, Eitan, Read, Nancy, Berthelet, Eric, Tran, Eric, Fung, Kevin, de Almeida, John R, Bayley, Andrew, Goldstein, David P, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S Danielle, Winquist, Eric, Hammond, J Alex, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Chen, Jeff, Corsten, Martin, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Parker, Christina, Wehrli, Bret, Kwan, Keith, and Palma, David A

Published
2019
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9. A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.

Author

Nichols, Anthony C, Chan-Seng-Yue, Michelle, Yoo, John, Agrawal, Sumit K, Starmans, Maud HW, Waggott, Daryl, Harding, Nicholas J, Dowthwaite, Samuel A, Palma, David A, Fung, Kevin, Wehrli, Bret, Macneil, S Danielle, Lambin, Philippe, Winquist, Eric, Koropatnick, James, Mymryk, Joe S, Boutros, Paul C, and Barrett, John W

Abstract

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.

Published
2013

10. A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing

Author

Nichols, Anthony C, Chan-Seng-Yue, Michelle, Yoo, John, Xu, Wei, Dhaliwal, Sandeep, Basmaji, John, Szeto, Christopher CT, Dowthwaite, Samuel, Todorovic, Biljana, Starmans, Maud HW, Lambin, Philippe, Palma, David A, Fung, Kevin, Franklin, Jason H, Wehrli, Bret, Kwan, Keith, Koropatnick, James, Mymryk, Joe S, Boutros, Paul, and Barrett, John W

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Clinical Sciences, Oncology and Carcinogenesis, Human Genome, Rare Diseases, Dental/Oral and Craniofacial Disease, Sexually Transmitted Infections, Cervical Cancer, Infectious Diseases, Clinical Research, Cancer, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being
Abstract

Background. Next-generation sequencing of cancers has identified important therapeutic targets and biomarkers. The goal of this pilot study was to compare the genetic changes in a human papillomavirus- (HPV-)positive and an HPV-negative head and neck tumor. Methods. DNA was extracted from the blood and primary tumor of a patient with an HPV-positive tonsillar cancer and those of a patient with an HPV-negative oral tongue tumor. Exome enrichment was performed using the Agilent SureSelect All Exon Kit, followed by sequencing on the ABI SOLiD platform. Results. Exome sequencing revealed slightly more mutations in the HPV-negative tumor (73) in contrast to the HPV-positive tumor (58). Multiple mutations were noted in zinc finger genes (ZNF3, 10, 229, 470, 543, 616, 664, 638, 716, and 799) and mucin genes (MUC4, 6, 12, and 16). Mutations were noted in MUC12 in both tumors. Conclusions. HPV-positive HNSCC is distinct from HPV-negative disease in terms of evidence of viral infection, p16 status, and frequency of mutations. Next-generation sequencing has the potential to identify novel therapeutic targets and biomarkers in HNSCC.

Published
2012

11. Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony C., Lang, Pencilla, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, de Almeida, John R., Bayley, Andrew, Goldstein, David P., Eskander, Antoine, Husain, Zain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S. Danielle, Mendez, Adrian, Winquist, Eric, Read, Nancy, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Rajaraman, Murali, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, Matthews, T. Wayne, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David A.

Published
2020
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13. The genomic and evolutionary landscapes of anaplastic thyroid carcinoma

Author

Zeng, Peter YF, primary, Prokopec, Stephenie D., additional, Lai, Stephen Y., additional, Pinto, Nicole, additional, Chan-Seng-Yue, Michelle A., additional, Clifton-Bligh, Roderick, additional, Williams, Michelle D., additional, Howlett, Christopher J., additional, Plantinga, Paul, additional, Cecchini, Matthew, additional, Lam, Alfred K., additional, Siddiqui, Iram, additional, Wang, Jianxin, additional, Sun, Ren, additional, Watson, John, additional, Korah, Reju, additional, Carling, Tobias, additional, Agrawal, Nishant, additional, Cipriani, Nicole, additional, Ball, Douglas, additional, Nelkin, Barry, additional, Rooper, Lisa M., additional, Bishop, Justin A., additional, Garnis, Cathie, additional, Berean, Ken, additional, Nicolson, Norman, additional, Weinberger, Paul, additional, Henderson, Ying C., additional, Lalansingh, Christopher M., additional, Tian, Mao, additional, Yamaguchi, Takafumi, additional, Livingstone, Julie, additional, Salcedo, Adriana, additional, Patel, Krupal, additional, Vizeacoumar, Frederick, additional, Datti, Alessandro, additional, Xi, Liu, additional, Nikiforov, Yuri, additional, Smallridge, Robert, additional, Copland, John A., additional, Marlow, Laura A., additional, Hyrcza, Martin D., additional, Delbridge, Leigh, additional, Sidhu, Stan, additional, Sywak, Mark, additional, Robinson, Bruce, additional, Fung, Kevin, additional, Ghasemi, Farhad, additional, Kwan, Keith, additional, MacNeil, Danielle, additional, Mendez, Adrian, additional, Palma, David A., additional, Khan, Mohammed I., additional, Shaikh, Mushfiq, additional, Ruicci, Kara M., additional, Wehrli, Bret, additional, Winquist, Eric, additional, Yoo, John, additional, Mymryk, Joe, additional, Rocco, James W., additional, Wheeler, David, additional, Scherer, Steve, additional, Giordano, Thomas J., additional, Barrett, John W., additional, Faquin, William C., additional, Gill, Anthony J., additional, Clayman, Gary, additional, Boutros, Paul C., additional, and Nichols, Anthony C., additional

Published
2023
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18. Ectomesenchymal Chondromyxoid Tumor: A Neoplasm Characterized by Recurrent RREB1-MKL2 Fusions

Author

Dickson, Brendan C., Antonescu, Cristina R., Argyris, Prokopios P., Bilodeau, Elizabeth A., Bullock, Martin J., Freedman, Paul D., Gnepp, Douglas R., Jordan, Richard C., Koutlas, Ioannis G., Lee, Cheng-Han, Leong, Iona, Merzianu, Mihai, Purgina, Bibianna M., Thompson, Lester D.R., Wehrli, Bret, Wright, John M., Swanson, David, Zhang, Lei, and Bishop, Justin A.

Published
2018
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20. Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Author

Palma, David A., primary, Prisman, Eitan, additional, Berthelet, Eric, additional, Tran, Eric, additional, Hamilton, Sarah, additional, Wu, Jonn, additional, Eskander, Antoine, additional, Higgins, Kevin, additional, Karam, Irene, additional, Poon, Ian, additional, Husain, Zain, additional, Enepekides, Danny, additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Johnson-Obaseki, Stephanie, additional, Odell, Michael, additional, Bayley, Andrew, additional, Dowthwaite, Samuel, additional, Jackson, James E., additional, Dzienis, Marcin, additional, O’Neil, John, additional, Chandarana, Shamir, additional, Banerjee, Robyn, additional, Hart, Robert, additional, Chung, Jeffson, additional, Tenenholtz, Todd, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, Mendez, Adrian, additional, Winquist, Eric, additional, Kuruvilla, Sara, additional, Stewart, Paul, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, Theurer, Julie, additional, Sathya, Jinka, additional, Hammond, J. Alex, additional, Read, Nancy, additional, Venkatesan, Varagur, additional, MacNeil, S. Danielle, additional, Fung, Kevin, additional, and Nichols, Anthony C., additional

Published
2022
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22. Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial

Author

Nichols, Anthony C., primary, Theurer, Julie, additional, Prisman, Eitan, additional, Read, Nancy, additional, Berthelet, Eric, additional, Tran, Eric, additional, Fung, Kevin, additional, de Almeida, John R., additional, Bayley, Andrew, additional, Goldstein, David P., additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, MacNeil, S. Danielle, additional, Winquist, Eric, additional, Hammond, J. Alex, additional, Venkatesan, Varagur, additional, Kuruvilla, Sara, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Corsten, Martin, additional, Johnson-Obaseki, Stephanie, additional, Odell, Michael, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, and Palma, David A., additional

Published
2022
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23. Additional file 5 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 5. Study Information and Informed Consent Form.

Published
2020
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24. Additional file 4 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Subjects
ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES
Abstract

Additional file 4. Lab Guidelines.

Published
2020
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25. Additional file 6 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 6. World Health Organization Trial Registration Dataset.

Published
2020
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26. Additional file 1 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 1. Treatment Planning Guidelines.

Published
2020
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27. Additional file 2 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 2. Surgical Credentialling Form.

Published
2020
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28. Additional file 3 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, Data_FILES, ComputingMilieux_COMPUTERSANDEDUCATION, ComputingMilieux_MISCELLANEOUS
Abstract

Additional file 3. Schedule of Enrolment, Interventions and Assessments.

Published
2020
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40. 88 Radiotherapy Versus Trans-Oral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Results of a Randomized Trial

Author

Palma, David, primary, Theurer, Julie, additional, Prisman, Eitan, additional, Read, Nancy, additional, Berthelet, Eric, additional, Tran, Eric, additional, Fung, Kevin, additional, de Almeida, John, additional, Hope, Andrew, additional, Goldstein, David, additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, MacNeil, Danielle, additional, Winquist, Eric, additional, Hammond, Alex, additional, Venkatesan, Varagur, additional, Kuruvilla, Sara, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Corsten, Martin, additional, Johnson-Obaseki, Stephanie, additional, Eapen, Libni, additional, Odell, Michael, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, and Nichols, Anthony, additional

Published
2019
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43. MP38-10 WINDOW OF OPPORTUNITY STUDY EVALUATING THE ANTIPROLIFERATIVE EFFECTS OF NEOADJUVANT METFORMIN PLUS SIMVASTATIN PRIOR TO RADICAL CYSTECTOMY FOR BLADDER CANCER: INTERIM ANALYSIS SHOWS REDUCTION IN PI3K/AKT/MTOR SIGNALING PATHWAY

Author

McPherson*, Victor, primary, Hetou, Khalil, additional, Nair, Shiva, additional, Howlett, Christopher, additional, Chin, Joseph, additional, Power, Nicholas, additional, Winquist, Eric, additional, Ernst, Scott, additional, Potvin, Kylea, additional, Wehrli, Bret, additional, and Izawa, Jonathan, additional

Published
2019
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45. Ectomesenchymal Chondromyxoid Tumor: A Neoplasm Characterized by Recurrent RREB1-MKL2 Fusions.

Author

Dickson, Brendan C, Dickson, Brendan C, Antonescu, Cristina R, Argyris, Prokopios P, Bilodeau, Elizabeth A, Bullock, Martin J, Freedman, Paul D, Gnepp, Douglas R, Jordan, Richard C, Koutlas, Ioannis G, Lee, Cheng-Han, Leong, Iona, Merzianu, Mihai, Purgina, Bibianna M, Thompson, Lester DR, Wehrli, Bret, Wright, John M, Swanson, David, Zhang, Lei, Bishop, Justin A, Dickson, Brendan C, Dickson, Brendan C, Antonescu, Cristina R, Argyris, Prokopios P, Bilodeau, Elizabeth A, Bullock, Martin J, Freedman, Paul D, Gnepp, Douglas R, Jordan, Richard C, Koutlas, Ioannis G, Lee, Cheng-Han, Leong, Iona, Merzianu, Mihai, Purgina, Bibianna M, Thompson, Lester DR, Wehrli, Bret, Wright, John M, Swanson, David, Zhang, Lei, and Bishop, Justin A

Abstract

Ectomesenchymal chondromyxoid tumor is a rare and benign neoplasm with a predilection for the anterior dorsal tongue. Despite morphologic heterogeneity, most cases are characterized by a proliferation of bland spindle cells with a distinctive reticular growth pattern and myxoid stroma. The immunophenotype of these neoplasms is likewise variable; most cases express glial fibrillary acid protein and S100 protein, with inconsistent reports of keratin and myoid marker expression. The molecular pathogenesis is poorly understood; however, a subset of cases has been reported to harbor EWSR1 gene rearrangement. Following identification of an RREB1-MKL2 fusion gene by RNA Sequencing in an index patient, a retrospective review of additional cases of ectomesenchymal chondromyxoid tumors was performed to better characterize the clinical, immunohistochemical, and molecular attributes of this neoplasm. A total of 21 cases were included in this series. A marked predisposition for the dorsal tongue was confirmed. Most cases conformed to prior morphologic descriptions; however, hypercellularity, hyalinized stroma, and necrosis were rare attributes not previously emphasized. The neoplastic cells frequently coexpressed glial fibrillary acid protein, S100 protein, keratin, smooth muscle actin, and/or desmin; a single case was found to contain significant myogenin expression. An RREB1-MKL2 fusion product was identified in 19 tumors (90%), a single tumor (5%) had an EWSR1-CREM fusion product, and the remaining case lacked any known fusion gene by RNA Sequencing. The latter 2 cases subtly differed morphologically from many in the cohort. This series illustrates that recurrent RREB1-MKL2 fusions occur in most, perhaps all, cases of ectomesenchymal chondromyxoid tumor.

Published
2018

46. An atypical lipomatous tumor mimicking a giant fibrovascular polyp of the hypopharynx

Author

Ioanidis, Khrystyna E., MacNeil, Stephanie Danielle, Tay, Keng Yeow, and Wehrli, Bret

Subjects
liposarcoma, otorhinolaryngologic diseases, hypopharynx, Medicine and Health Sciences, case report, giant fibrovascular polyp
Abstract

Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. Rationale: Giant fibrovascular polyps (GFVPs) found in the hypopharynx are exceedingly rare. These are benign tumors which are identified by CT or MRI and usually treated based on symptoms. Even more rarely, pathology may identify one of these masses as an atypical lipomatous tumor (ALT). This paper will present a case of an ALT of the hypopharynx that was originally classified as a GFVP, highlighting the difficulty in distinguishing between them and the importance of making the correct diagnosis. Patient Concerns: An 84-year-old man presented to the emergency department with a 6-month history of a pedunculated hypopharyngeal growth, dysphagia, and intermittent dyspnea. Diagnoses: The mass was characterized as a GFVP by barium swallow and MRI. Interventions: The hypopharyngeal mass was resected for obstructive symptoms and to confirm the diagnosis. Final pathology found the mass to be more consistent with an atypical lipomatous tumor (ALT). Outcomes: The patient's dysphagia and dyspnea resolved. He was free of recurrence at 22 months postoperative. Lessons: Both GFVPs and ALTs are very rarely found in the hypopharynx but can be easily misclassified as one another. Imaging is useful to initially characterize the mass, but to definitively differentiate between them, pathological analysis is necessary. Although they are rare, it is important to consider both possibilities on the differential for hypopharyngeal masses. Further, accurate analysis is essential to distinguish between them because their definitive management and follow-up is different.

Published
2017

49. Rapidly Destructive Inflammatory Arthritis of the Hip

Author

Shu, Jenny, Ross, Ian, Wehrli, Bret, McCalden, Richard W., and Barra, Lillian

Subjects
musculoskeletal diseases, Article Subject
Abstract

Rapidly destructive coxarthrosis (RDC) is a rare syndrome that involves aggressive hip joint destruction within 6–12 months of symptom onset with no single diagnostic laboratory, pathological, or radiographic finding. We report an original case of RDC as an initial presentation of seronegative rheumatoid arthritis (RA) in a 57-year-old Caucasian woman presenting with 6 months of progressive right groin pain and no preceding trauma or chronic steroid use. Over 5 months, she was unable to ambulate and plain films showed complete resorption of the right femoral head and erosion of the acetabulum. There were inflammatory features seen on computed tomography (CT) and magnetic resonance imaging (MRI). She required a right total hip arthroplasty, but arthritis in other joints showed improvement with triple disease modifying antirheumatic drugs (DMARD) therapy and almost complete remission with the addition of adalimumab. We contrast our case of RDC as an initial presentation of RA to 8 RDC case reports of patients with established RA. Furthermore, this case highlights the importance of obtaining serial imaging to evaluate a patient with persistent hip symptoms and rapid functional deterioration.

Published
2014
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