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2. Leber und Pankreas

Author

Wehinger, H., Stephan, U., Wiesemann, H. G., Götze, H., Reinhardt, Dietrich, editor, and von Harnack, Gustav-Adolf, editor

Published
1991
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3. Eisenmangel im Wachstumsalter

Author

Wehinger, H., Heimpel, H., editor, Ruhenstroth-Bauer, G., editor, Stich, W., editor, Löhr, Georg-Wilhelm, editor, Arnold, Heidwolf, editor, Engelhardt, Rupert, editor, Möbius, Walter, editor, Mähr, Gert, editor, Schmalzl, Franz, editor, and Sauter, Christian, editor

Published
1978
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6. Propionacidämie mit hypertrophischer Pylorusstenose und Entgleisungen im Glukosestoffwechsel

Author

Lehnert, W., Junker, A., Wehinger, H., Zöberlein, H. G., Baumgartner, R., Ropers, H.-H., Bachmann, K. D., editor, Berger, H., editor, Bierich, J., editor, Boda, D., editor, Bremer, H.-J., editor, Brodehl, J., editor, Burgio, G. R., editor, Fischer, K., editor, Gladtke, E., editor, Hadorn, B., editor, Hagberg, B., editor, Hallman, N., editor, Hansen, H. G., editor, Harbauer, H., editor, von Harnack, G.-A., editor, Hecker, W. C., editor, Helge, H., editor, Hitzig, W. H., editor, Huth, E., editor, Kleihauer, E., editor, Künzer, W., editor, Lassrich, M. A., editor, Leiber, B., editor, Lindquist, B., editor, Marget, W., editor, Oehme, J., editor, Olbing, H., editor, Pfeiffer, R. A., editor, Prader, A., editor, Riegel, K., editor, Rossi, E., editor, Schärer, K., editor, Schmidt, E., editor, Schulte, F.-J., editor, Spiess, H., editor, Spranger, J., editor, Stalder, G., editor, Stephan, U., editor, Stoermer, J., editor, Ströder, J., editor, Teller, W., editor, Zetterström, R., editor, and Zweymüller, E., editor

Published
1980
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8. Leber und Pankreas

Author

Wehinger, H., Künzer, W., Stephan, U., Wiesemann, H. G., Götze, H., and von Harnack, Gustav-Adolf, editor

Published
1985
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22. Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95

Author

Möricke, A, Reiter, A, Zimmermann, M, Gadner, H, Stanulla, M, Dördelmann, N, Löning, L, Beier, R, Ludwig, W D, Ratei, R, Harbott, J, Boos, H, Mann, G, Niggli, F, Feldges, A, Henze, G, Welte, K, Beck, J D, Klingebiel, T, Niemeyer, C, Zintl, F, Bode, U, Urban, C, Wehinger, H, Niethammer, D, Riehm, H, Schrappe, M, Möricke, A, Reiter, A, Zimmermann, M, Gadner, H, Stanulla, M, Dördelmann, N, Löning, L, Beier, R, Ludwig, W D, Ratei, R, Harbott, J, Boos, H, Mann, G, Niggli, F, Feldges, A, Henze, G, Welte, K, Beck, J D, Klingebiel, T, Niemeyer, C, Zintl, F, Bode, U, Urban, C, Wehinger, H, Niethammer, D, Riehm, H, and Schrappe, M

Abstract

The trial ALL-BFM 95 for treatment of childhood acute lymphoblastic leukemia was designed to reduce acute and long-term toxicity in selected patient groups with favorable prognosis and to improve outcome in poor-risk groups by treatment intensification. These aims were pursued through a stratification strategy using white blood cell count, age, immunophenotype, treatment response, and unfavorable genetic aberrations providing an excellent discrimination of risk groups. Estimated 6-year event-free survival (6y-pEFS) for all 2169 patients was 79.6% (+/- 0.9%). The large standard-risk (SR) group (35% of patients) achieved an excellent 6y-EFS of 89.5% (+/- 1.1%) despite significant reduction of anthracyclines. In the medium-risk (MR) group (53% of patients), 6y-pEFS was 79.7% (+/- 1.2%); no improvement was accomplished by the randomized use of additional intermediate-dose cytarabine after consolidation. Omission of preventive cranial irradiation in non-T-ALL MR patients was possible without significant reduction of EFS, although the incidence of central nervous system relapses increased. In the high-risk (HR) group (12% of patients), intensification of consolidation/reinduction treatment led to considerable improvement over the previous ALL-BFM trials yielding a 6y-pEFS of 49.2% (+/- 3.2%). Compared without previous trial ALL-BFM 90, consistently favorable results in non-HR patients were achieved with significant treatment reduction in the majority of these patients.

Published
2008

36. Latex phagocytosis by polymorphonuclear leukocytes. In vitro and in vivo studies with a simple screening test.

Author

Wehinger, H and Hofacker, M

Abstract

A simple semiquantitative slide test to assess the phagocytic activity of periphera polymorphonuclear leukocytes is described. Leukocytes are isolated from one drop of blood and latex particles are offered for phagocytosis. Cellular capacities and serum opsonins can be assessed separately. In the presence of pooled adult serum no defect of phagocytosis was seen in preterm and full-term newborns nor in pediatric patients with infectious or other diseases. In 4 of 7 premature newborns a definite deficiency of serum opsonins was demonstrated. In in vitro studies complement (plus possibly other heat-labile factors) promoted phagocytosis. Phagocytic rates were depressed by endotoxin and phenylbutazone. [ABSTRACT FROM AUTHOR]

Published
1976

37. Heterozygoter NADH-Meth�moglobin-Reduktase-Defekt mit Meth�moglobin�mie bei einem S�gling

Author

Wehinger H, Schuchmann L, Wilhelm Künzer, Seibert G, Gunkel J, and Irene Witt

Subjects
Gynecology, medicine.medical_specialty, business.industry, Pediatrics, Perinatology and Child Health, medicine, NADH methemoglobin reductase, Methemoglobinemia, medicine.disease, business
Abstract

Bei einem weiblichen Saugling kam es im Alter von 3 Wochen im Verlaufe einer Dyspepsie akut zu einer erheblichen Methamoglobinamie von 18% des vorhandenen Hamoglobins. In den folgenden Monaten traten wiederholt dyspeptische Schube auf, die jeweils mit einem Anstieg der Methamoglobin-Konzentration, zeitweise bis 50%, verbunden waren. In den Erythrocyten des Kindes wurde eine auf 50% des Normalwertes verminderte Aktivitat der NADH-abhangigen Methamoglobin-Reduktase gefunden. Offensichtlich handelt es sich um einen heterozygoten Enzymdefekt. Bei der Untersuchung der Familie wurden 13 weitere heterozygote Defekttrager beobachtet. Das Auftreten einer schweren Methamoglobinamie ist bei heterozygotem Reduktasemangel sehr selten. Bei unserer Patientin hat vermutlich eine wahrend der Dyspepsien entstandene Noxe zur vermehrten Bildung von Methamoglobin gefuhrt. Da Neugeborene nur 50% der Methamoglobin-Reduktase-Aktivitat von Erwachsenen haben, kommt es bei einem gleichzeitigen Methamoglobin-Reduktase-Defekt nicht zu einer ausreichenden Reduktion des entstandenen Methamoglobins.

Published
1973

39. Verschiedene, Ph1-positive und Ph1-negative cytogenetische Stammlinien bei myelomonocytärem Proliferationssyndrom im frühen Kindesalter

Author

Wehinger, H., Niederhoff, H., Bethge, D., Künzer, W., Hoehn, H., and Cohen, G.

Abstract

Summary The authors report on an infant with myeloproliferative syndrome of the myelomonocytic type. The findings fulfilled the criteria for juvenile chronic myeloid leukemia except that there was no increase of fetal hemoglobin and no depression of erythrocyte carbonic anhydrase I. In one half of the bone marrow cells a Ph1-chromosome was found. During the course of the disease the Ph1-positive clone was successively replaced by cell lines with different chromosomal aberrations. The relationship between the cytogenetic mosaicism and the clinical and laboratory findings is discussed.

Published
1975
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42. [Vitamin D deficiency rickets after vitamin D hypersensitivity with subcutaneous fat necrosis in the newborn period]

Author

Wehinger H

Subjects
medicine.medical_specialty, Necrosis, Hypercalcaemia, Period (gene), chemistry.chemical_element, Rickets, Calcium, vitamin D deficiency, Infant, Newborn, Diseases, Diagnosis, Differential, Drug Hypersensitivity, Internal medicine, medicine, Vitamin D and neurology, Humans, Vitamin D, Asphyxia Neonatorum, business.industry, Infant, Newborn, Calcinosis, Infant, medicine.disease, Radiography, Endocrinology, chemistry, Adipose Tissue, Pediatrics, Perinatology and Child Health, Toxicity, Hypercalcemia, medicine.symptom, business
Published
1969

47. Therapiestudie BFM 79/81 zur Behandlung der akuten lymphoblastischen Leukämie bei Kindern und Jugendlichen: intensivierte Reinduktionstherapie für Patientengruppen mit unterschiedlichem Rezidivrisiko

Author

Henze, G., primary, Langermann, H., additional, Fengler, R., additional, Brandeis, M., additional, Evers, K., additional, Gadner, H., additional, Hinderfeld, L., additional, Jobke, A., additional, Kornhuber, B., additional, Lampert, F., additional, Lasson, U., additional, Ludwig, R., additional, Müller-Weihrich, S., additional, Neidhardt, M., additional, Nessler, G., additional, Niethammer, D., additional, Rister, M., additional, Ritter, J., additional, Schaaff, A., additional, Schellong, G., additional, Stollmann, B., additional, Treuner, J., additional, Wahlen, W., additional, Weinel, P., additional, Wehinger, H., additional, and Riehm, H., additional

Published
1982
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