43 results on '"Wegelius, Asko"'
Search Results
2. Antipsychotic medications and sleep problems in patients with schizophrenia
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Kyttälä, Aija, Kämpe, Anders, Tuulio-Henriksson, Annamari, Ahola-Olli, Ari, Wegelius, Asko, Toivola, Auli, Neale, Benjamin, Shen, Huei-yi, Västrik, Imre, Lönnqvist, Jouko, Veijola, Juha, Niemi-Pynttäri, Jussi, Häkkinen, Katja, Suokas, Kimmo, Daly, Mark, Ristiluoma, Noora, Pietiläinen, Olli, Kajanne, Risto, Hyman, Steven E., Singh, Tarjinder, Männynsalo, Teemu, Jukuri, Tuomas, Haaki, Willehard, Cederlöf, Erik, Holm, Minna, Taipale, Heidi, Tiihonen, Jari, Tanskanen, Antti, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Palotie, Aarno, Suvisaari, Jaana, and Paunio, Tiina
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- 2024
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3. Association of antidepressant and benzodiazepine use, and anticholinergic burden with cognitive performance in schizophrenia
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Mäkipelto, Ville, Tuulio-Henriksson, Annamari, Hakulinen, Christian, Niemelä, Solja, Lähteenvuo, Markku, Wegelius, Asko, Kieseppä, Tuula, Isometsä, Erkki, Tiihonen, Jari, Kampman, Olli, Lahdensuo, Kaisla, Mazumder, Atiqul, Suvisaari, Jaana, and Holm, Minna
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- 2024
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4. Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder
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Häkkinen, Katja, Kiiski, Johanna I., Lähteenvuo, Markku, Jukuri, Tuomas, Suokas, Kimmo, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Lahdensuo, Kaisla, Kajanne, Risto, Kaunisto, Mari A., Tuulio-Henriksson, Annamari, Kampman, Olli, Hietala, Jarmo, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Paunio, Tiina, Suvisaari, Jaana, Kalso, Eija, Niemi, Mikko, Tiihonen, Jari, Daly, Mark, Palotie, Aarno, and Ahola-Olli, Ari V.
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- 2022
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5. Differences in psychosocial functioning between psychotic disorders in the Finnish SUPER study
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Ahti, Johan, Kieseppä, Tuula, Suvisaari, Jaana, Suokas, Kimmo, Holm, Minna, Wegelius, Asko, Ahola-Olli, Ari, Häkkinen, Katja, Kampman, Olli, Lähteenvuo, Markku, Paunio, Tiina, Tiihonen, Jari, Tuulio-Henriksson, Annamari, and Isometsä, Erkki
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- 2022
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6. Antipsychotic medications and sleep problems in patients with schizophrenia
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Cederlöf, Erik, Holm, Minna, Taipale, Heidi, Tiihonen, Jari, Tanskanen, Antti, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kampman, Olli, Wegelius, Asko, Isometsä, Erkki, Kieseppä, Tuula, Palotie, Aarno, Suvisaari, Jaana, Paunio, Tiina, Kyttälä, Aija, Kämpe, Anders, Tuulio-Henriksson, Annamari, Ahola-Olli, Ari, Toivola, Auli, Neale, Benjamin, Shen, Huei-yi, Västrik, Imre, Lönnqvist, Jouko, Veijola, Juha, Niemi-Pynttäri, Jussi, Häkkinen, Katja, Suokas, Kimmo, Daly, Mark, Ristiluoma, Noora, Pietiläinen, Olli, Kajanne, Risto, Hyman, Steven E., Singh, Tarjinder, Männynsalo, Teemu, Jukuri, Tuomas, Haaki, Willehard, Cederlöf, Erik, Holm, Minna, Taipale, Heidi, Tiihonen, Jari, Tanskanen, Antti, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kampman, Olli, Wegelius, Asko, Isometsä, Erkki, Kieseppä, Tuula, Palotie, Aarno, Suvisaari, Jaana, Paunio, Tiina, Kyttälä, Aija, Kämpe, Anders, Tuulio-Henriksson, Annamari, Ahola-Olli, Ari, Toivola, Auli, Neale, Benjamin, Shen, Huei-yi, Västrik, Imre, Lönnqvist, Jouko, Veijola, Juha, Niemi-Pynttäri, Jussi, Häkkinen, Katja, Suokas, Kimmo, Daly, Mark, Ristiluoma, Noora, Pietiläinen, Olli, Kajanne, Risto, Hyman, Steven E., Singh, Tarjinder, Männynsalo, Teemu, Jukuri, Tuomas, and Haaki, Willehard
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Background: Sleep problems are common and related to a worse quality of life in patients with schizophrenia. Almost all patients with schizophrenia use antipsychotic medications, which usually increase sleep. Still, the differences in subjective sleep outcomes between different antipsychotic medications are not entirely clear. Methods: This study assessed 5466 patients with schizophrenia and is part of the nationwide Finnish SUPER study. We examined how the five most common antipsychotic medications (clozapine, olanzapine, quetiapine, aripiprazole, and risperidone) associate with questionnaire-based sleep problems in logistic regression analyses, including head-to-head analyses between different antipsychotic medications. The sleep problems were difficulties initiating sleep, early morning awakenings, fatigue, poor sleep quality, short (≤6 h) and long sleep duration (≥10 h). Results: The average number of antipsychotic medications was 1.59 per patient. Clozapine was associated with long sleep duration (49.0 % of clozapine users vs 30.2 % of other patients, OR = 2.05, 95 % CI 1.83–2.30, p < .001). Olanzapine and risperidone were in head-to-head analyses associated with less sleep problems than patients using aripiprazole, quetiapine, or no antipsychotic medication. Aripiprazole and quetiapine were associated with more insomnia symptoms and poorer sleep quality. Patients without antipsychotic medications (N = 159) had poorer sleep quality than patients with antipsychotic use, and short sleep duration was common (21.5 % of patients using antipsychotics vs 7.8 % of patients using antipsychotics, OR = 2.97, 95 % CI 1.98–4.44, p < .001). Conclusions: Prevalence of sleep problems is markedly related to the antipsychotic medication the patient uses. These findings underline the importance of considering and assessing sleep problems when treating schizophrenia patients with antipsychotics.
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- 2024
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7. Differences in psychosocial functioning between psychotic disorders in the Finnish SUPER study
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SUPER Researchers Listed Acknowle, Ahti, Johan, Kieseppä, Tuula, Suvisaari, Jaana, Suokas, Kimmo, Holm, Minna, Wegelius, Asko, Ahola-Olli, Ari, Hakkinen, Katja, Kampman, Olli, Lähteenvuo, Markku, Paunio, Tiina, Tiihonen, Jari, Tuulio-Henriksson, Annamari, Isometsä, Erkki, HUS Psychiatry, Department of Psychiatry, Clinicum, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Genomics of Neurological and Neuropsychiatric Disorders, Department of Psychology and Logopedics, Faculty Common Matters (Faculty of Education), Tampere University, Department of Child Psychiatry, Health Sciences, Department of Psychotic Disorders, and Clinical Medicine
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Depressive Disorder, Major ,GENDER-DIFFERENCES ,Schizoaffective disorder ,Bipolar disorder ,MAJOR DEPRESSION ,HOSPITAL DISCHARGE REGISTER ,BIPOLAR I DISORDER ,3124 Neurology and psychiatry ,Level of functioning ,3141 Health care science ,Psychosocial Functioning ,Psychiatry and Mental health ,Cross-Sectional Studies ,Psychotic depression ,Psychotic Disorders ,SCHIZOPHRENIA ,Humans ,Female ,Schizophrenic Psychology ,Child ,PREDICTORS ,EPISODE ,Finland ,Biological Psychiatry ,Outcome - Abstract
Background: Psychotic disorders differ in their impact on psychosocial functioning. However, few studies have directly compared psychosocial functioning and its determinants between schizophrenia, schizoaffective disorder (SAD), bipolar disorder (BD), and major depressive disorder with psychotic features (psychotic MDD). Objective: We compared rates of independent living, employment, marriage, and having children between these diagnostic groups in a large national sample of participants with psychotic disorders in Finland. Methods: A cross-sectional substudy of participants (N = 9148) aged 18 to 65 years in the Finnish SUPER study, recruited nationwide from health- and social care settings and with advertisements. Psychosis diagnoses, age of onset, and hospitalizations were collected from healthcare registers. Participants were interviewed for psychosocial functioning. Associations of age of onset, hospitalizations, gender, and education with psychosocial functioning were analyzed using logistic regression models. Results: Of participants, 13.8% were employed or studying, 72.0% living independently and 32.5% had children. Overall, BD was associated with best, SAD and psychotic MDD with intermediate, and schizophrenia with worst level of psychosocial functioning. Greatest differences were found in independent living (OR 4.06 for BD vs. schizophrenia). In multivariate models, gender and number of hospitalizations predicted employment, marriage, and independent living in all diagnostic categories, and age of onset in some diagnostic categories. Conclusions: Level of functioning and psychosocial outcomes differed markedly between psychotic disorders, particularly in independent living. Outcomes were worst for schizophrenia and best for BD. Across all psychotic disorders, female gender and lifetime number of hospitalizations had strong independent associations with marriage, employment, and independent living. publishedVersion
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- 2022
8. Cohort profile: SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders
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Lähteenvuo, Markku, primary, Ahola-Olli, Ari, additional, Suokas, Kimmo, additional, Holm, Minna, additional, Misiewicz, Zuzanna, additional, Jukuri, Tuomas, additional, Männynsalo, Teemu, additional, Wegelius, Asko, additional, Haaki, Willehard, additional, Kajanne, Risto, additional, Kyttälä, Aija, additional, Tuulio-Henriksson, Annamari, additional, Lahdensuo, Kaisla, additional, Häkkinen, Katja, additional, Hietala, Jarmo, additional, Paunio, Tiina, additional, Niemi-Pynttäri, Jussi, additional, Kieseppä, Tuula, additional, Veijola, Juha, additional, Lönnqvist, Jouko, additional, Isometsä, Erkki, additional, Kampman, Olli, additional, Tiihonen, Jari, additional, Hyman, Steven, additional, Neale, Benjamin, additional, Daly, Mark, additional, Suvisaari, Jaana, additional, and Palotie, Aarno, additional
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- 2023
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9. Cohort profile: SUPER-Finland - the Finnish study for hereditary mechanisms of psychotic disorders
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Lähteenvuo, Markku, Ahola-Olli, Ari, Suokas, Kimmo, Holm, Minna, Misiewicz, Zuzanna, Jukuri, Tuomas, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Kajanne, Risto, Kyttälä, Aija, Tuulio-Henriksson, Annamari, Lahdensuo, Kaisla, Häkkinen, Katja, Hietala, Jarmo, Paunio, Tiina, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Kampman, Olli, Tiihonen, Jari, Hyman, Steven, Neale, Benjamin, Daly, Mark, Suvisaari, Jaana, Palotie, Aarno, Lähteenvuo, Markku, Ahola-Olli, Ari, Suokas, Kimmo, Holm, Minna, Misiewicz, Zuzanna, Jukuri, Tuomas, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Kajanne, Risto, Kyttälä, Aija, Tuulio-Henriksson, Annamari, Lahdensuo, Kaisla, Häkkinen, Katja, Hietala, Jarmo, Paunio, Tiina, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Kampman, Olli, Tiihonen, Jari, Hyman, Steven, Neale, Benjamin, Daly, Mark, Suvisaari, Jaana, and Palotie, Aarno
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PURPOSE: SUPER-Finland is a large Finnish collection of psychosis cases. This cohort also represents the Finnish contribution to the Stanley Global Neuropsychiatric Genetics Initiative, which seeks to diversify genetic sample collection to include Asian, Latin American and African populations in addition to known population isolates, such as Finland. PARTICIPANTS: 10 474 individuals aged 18 years or older were recruited throughout the country. The subjects have been genotyped with a genome-wide genotyping chip and exome sequenced. A subset of 897 individuals selected from known population sub-isolates were selected for whole-genome sequencing. Recruitment was done between November 2015 and December 2018. FINDINGS TO DATE: 5757 (55.2%) had a diagnosis of schizophrenia, 944 (9.1%) schizoaffective disorder, 1612 (15.5%) type I or type II bipolar disorder, 532 (5.1 %) psychotic depression, 1047 (10.0%) other psychosis and for 530 (5.1%) self-reported psychosis at recruitment could not be confirmed from register data. Mean duration of schizophrenia was 22.0 years at the time of the recruitment. By the end of the year 2018, 204 of the recruited individuals had died. The most common cause of death was cardiovascular disease (n=61) followed by neoplasms (n=40). Ten subjects had psychiatric morbidity as the primary cause of death. FUTURE PLANS: Compare the effects of common variants, rare variants and copy number variations (CNVs) on severity of psychotic illness. In addition, we aim to track longitudinal course of illness based on nation-wide register data to estimate how phenotypic and genetic differences alter it.
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- 2023
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10. An interaction between NDE1 and high birth weight increases schizophrenia susceptibility
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Wegelius, Asko, Pankakoski, Maiju, Tomppo, Liisa, Lehto, Ulriika, Lönnqvist, Jouko, Suvisaari, Jaana, Paunio, Tiina, and Hennah, William
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- 2015
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11. Substance Use and Sleep Problems in Patients With Psychotic Disorders
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Cederlöf, Erik, primary, Holm, Minna, additional, Ahti, Johan, additional, Lähteenvuo, Markku, additional, Hietala, Jarmo, additional, Häkkinen, Katja, additional, Isometsä, Erkki, additional, Kampman, Olli, additional, Lahdensuo, Kaisla, additional, Lönnqvist, Jouko, additional, Suvisaari, Jaana, additional, Tiihonen, Jari, additional, Wegelius, Asko, additional, Veijola, Juha, additional, Palotie, Aarno, additional, Kieseppä, Tuula, additional, Niemelä, Solja, additional, and Paunio, Tiina, additional
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- 2022
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12. Virtual reality intervention for psychotic disorders using 360-degree video - agile development of an easy to implement protocol
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Mikkonen, Kasperi, primary, Salmijärvi, Laura, additional, Lindgren, Maija, additional, Kröger, Heta, additional, Karpov, Boris, additional, Manninen, Marko, additional, and Wegelius, Asko, additional
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- 2022
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13. An association between both low and high birth weight and increased disorganized and negative symptom severity in schizophrenia and other psychoses
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Wegelius, Asko, Pankakoski, Maiju, Lehto, Ulriika, Suokas, Jaana, Häkkinen, Laura, Tuulio-Henriksson, Annamari, Lönnqvist, Jouko, Paunio, Tiina, and Suvisaari, Jaana
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- 2013
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14. DIGITAL HEALTH TECHNOLOGIES IN THE PSYCHOSOCIAL TREATMENT OF CORE SYMPTOMS OF PSYCHOTIC DISORDERS — LITERATURE REVIEW AND PRACTICAL ASPECTS
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Mikkonen, Kasperi, Wegelius, Asko, Salmijärvi, Laura, Paunio, Tiina, Kieseppä, Tuula, HUS Psychiatry, Department of Psychiatry, and Staff Services
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schizophrenia ,cognitive deficits ,ehealth ,education ,paranoia ,virtual reality ,Neurosciences. Biological psychiatry. Neuropsychiatry ,hallucinations ,avatar-therapy ,3124 Neurology and psychiatry ,RC321-571 - Abstract
The use of various digital health technologies is increasing in the treatment of psychotic disorders, as well as in psychiatry in general. In this review we present key studies on how technology is practically used to treat cognitive deficits, hallucinations and delusions of psychotic patients. The goal of this literature review is to provide the reader a comprehensive understanding on how technology is currently being utilized in the treatment of psychotic disorders, and to discuss how technology can pave the way towards a more integrative approach of treating psychotic disorders. The search for each symptom category was performed through PubMed and Google Scholar databases over the last 10-15 years. Computer-based cognitive rehabilitation seems to be as effective as the non-computerized equivalent, but has several additional advantages. AVATAR therapy and virtual reality-based treatments show promise in treating both hallucinations and delusions, but more research in this area is required. Digital solutions offer new ways to monitor and assess the different symptoms of psychotic disorders and to administer selfmanagement in the daily lives of patients. Digital health technology belongs to the treatment of psychotic disorders, but it should be further studied in order to more fully understand the underlying psychological mechanisms involved, and to further validate the approaches that will be the most beneficial for large scale clinical use.
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- 2020
15. An association between high birth weight and schizophrenia in a Finnish schizophrenia family study sample
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Wegelius, Asko, Tuulio-Henriksson, Annamari, Pankakoski, Maiju, Haukka, Jari, Lehto, Ulriika, Paunio, Tiina, Lönnqvist, Jouko, and Suvisaari, Jaana
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- 2011
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16. Sleep in Psychotic Disorders: Results From Nationwide SUPER Finland Study
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Cederlöf, Erik, primary, Holm, Minna, additional, Lähteenvuo, Markku, additional, Haaki, Willehard, additional, Hietala, Jarmo, additional, Häkkinen, Katja, additional, Isometsä, Erkki, additional, Jukuri, Tuomas, additional, Kajanne, Risto, additional, Kampman, Olli, additional, Kieseppä, Tuula, additional, Lahdensuo, Kaisla, additional, Lönnqvist, Jouko, additional, Männynsalo, Teemu, additional, Niemi-Pynttäri, Jussi, additional, Suokas, Kimmo, additional, Suvisaari, Jaana, additional, Tiihonen, Jari, additional, Turunen, Hannu, additional, Wegelius, Asko, additional, Veijola, Juha, additional, Palotie, Aarno, additional, and Paunio, Tiina, additional
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- 2022
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17. Cognitive functioning and cannabis use in first-episode psychosis
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Karpov, Boris, primary, Lindgren, Maija, additional, Kieseppä, Tuula, additional, Wegelius, Asko, additional, and Suvisaari, Jaana, additional
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- 2021
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18. Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
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Mazumder, Atiqul Haq, Barnett, Jennifer, Isometsä, Erkki Tapio, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Ahola-Olli, Ari, Hietala, Jarmo, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Tiihonen, Jari, Paunio, Tiina, Vainio, Seppo Juhani, Palotie, Aarno, Niemelä, Solja, Suvisaari, Jaana, Veijola, Juha, Mazumder, Atiqul Haq [0000-0002-2148-4070], Isometsä, Erkki Tapio [0000-0001-5956-2399], Torniainen-Holm, Minna [0000-0003-2149-855X], Lähteenvuo, Markku [0000-0002-7244-145X], Kerkelä, Martta [0000-0002-1181-2632], Ahola-Olli, Ari [0000-0002-4451-3487], Hietala, Jarmo [0000-0002-3179-6780], Kampman, Olli [0000-0001-6891-2266], Häkkinen, Katja [0000-0001-8222-7505], Haaki, Willehard [0000-0002-2850-7650], Kajanne, Risto [0000-0002-3405-7115], Suokas, Kimmo [0000-0001-6296-6343], Tiihonen, Jari [0000-0002-0400-6798], Paunio, Tiina [0000-0002-5560-0666], Vainio, Seppo Juhani [0000-0001-9319-3566], Palotie, Aarno [0000-0002-2527-5874], Niemelä, Solja [0000-0003-1130-9161], Suvisaari, Jaana [0000-0001-7167-0990], Veijola, Juha [0000-0002-4139-9981], Apollo - University of Cambridge Repository, Department of Psychiatry, HUS Psychiatry, University of Helsinki, Clinicum, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Staff Services, Centre of Excellence in Complex Disease Genetics, Research Programme of Molecular Medicine, and Aarno Palotie / Principal Investigator
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cognition ,Hazardous drinking ,Schizoaffective disorder ,Bipolar disorder ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Article ,MODERATE ALCOHOL-USE ,3124 Neurology and psychiatry ,Cognition ,DEPENDENCE ,COHORT ,RISK ,OLDER ,Reaction time ,reaction time ,bipolar disorder ,3112 Neurosciences ,CONSUMPTION ,PERFORMANCE ,COGNITIVE IMPAIRMENT ,schizoaffective disorder ,hazardous drinking ,LIFE ,schizophrenia ,Schizophrenia ,PGS ,Visual memory ,visual memory ,MIDLIFE ,RC321-571 - Abstract
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
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- 2021
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19. Substance Use and Sleep Problems in Patients With Psychotic Disorders.
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Cederlöf, Erik, Holm, Minna, Ahti, Johan, Lähteenvuo, Markku, Hietala, Jarmo, Häkkinen, Katja, Isometsä, Erkki, Kampman, Olli, Lahdensuo, Kaisla, Lönnqvist, Jouko, Suvisaari, Jaana, Tiihonen, Jari, Wegelius, Asko, Veijola, Juha, Palotie, Aarno, Kieseppä, Tuula, Niemelä, Solja, and Paunio, Tiina
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SUBSTANCE abuse risk factors ,RESEARCH ,SLEEP quality ,CONFIDENCE intervals ,PSYCHOSES ,CROSS-sectional method ,MULTIPLE regression analysis ,SLEEP disorders ,RISK assessment ,DESCRIPTIVE statistics ,QUESTIONNAIRES ,ALCOHOL drinking ,CHI-squared test ,RESEARCH funding ,FATIGUE (Physiology) ,ODDS ratio ,SMOKING ,DRUGS of abuse ,LONGITUDINAL method ,DISEASE risk factors - Abstract
Background Substance use and sleep problems are common in patients with psychotic disorders, but their associations in these patients have not been evaluated. We aimed to investigate associations between substance use and sleep problems in a large nationwide cohort of patients with a psychotic disorder. Study Design This study is part of the Finnish SUPER study, which belongs to the Stanley Global Neuropsychiatric Genomics Initiative. In this cross-sectional, multicenter study, participants (N = 8616) were recruited from primary and specialized healthcare. Patients with schizophrenia, schizoaffective disorder, bipolar disorder, and psychotic depression were included. Information on current alcohol (Alcohol Use Disorders Identification Test-Concise) and cigarette use as well as on lifetime illicit drug use, including cannabis, benzodiazepines, amphetamines, and opioids, was collected using questionnaires. The sleep outcomes in our logistic regression analysis were short (≤6 h) and long sleep (≥10 h) duration, difficulties initiating asleep, early morning awakenings, fatigue, and poor sleep quality (SQ). Results Self-reported substance use was associated with a higher prevalence of sleep problems. After adjustments with age, gender, diagnostic group, and living status, hazardous alcohol use (eg, poor SQ odds ratio [OR] = 1.80, 95% CI: 1.49 to 2.16, P <.001), current smoking (short sleep duration OR = 1.28, 95% CI: 1.08 to 1.52, P =.005), and lifetime benzodiazepine misuse (difficulties initiating sleep OR = 2.00, 95% CI: 1.55 to 2.48, P <.001) were associated with sleep problems. Conclusions Substance use was associated with sleep problems. Our findings underline the potential benefits of screening substance use when treating sleep problems in patients with psychotic disorders. [ABSTRACT FROM AUTHOR]
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- 2023
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20. Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective and Bipolar Disorder
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Mazumder, Atiqul Haq, primary, Barnett, Jennifer, additional, Isometsä, Erkki Tapio, additional, Lindberg, Nina, additional, Torniainen-Holm, Minna, additional, Lähteenvuo, Markku, additional, Lahdensuo, Kaisla, additional, Kerkelä, Martta, additional, Ahola-Olli, Ari, additional, Hietala, Jarmo, additional, Kampman, Olli, additional, Kieseppä, Tuula, additional, Jukuri, Tuomas, additional, Häkkinen, Katja, additional, Cederlöf, Erik, additional, Haaki, Willehard, additional, Kajanne, Risto, additional, Wegelius, Asko, additional, Männynsalo, Teemu, additional, Niemi-Pynttäri, Jussi, additional, Suokas, Kimmo, additional, Lönnqvist, Jouko, additional, Tiihonen, Jari, additional, Paunio, Tiina, additional, Vainio, Seppo Juhani, additional, Palotie, Aarno, additional, Niemelä, Solja, additional, Suvisaari, Jaana, additional, and Veijola, Juha, additional
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- 2021
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21. Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder
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Mazumder, Atiqul Haq, primary, Barnett, Jennifer, additional, Isometsä, Erkki Tapio, additional, Lindberg, Nina, additional, Torniainen-Holm, Minna, additional, Lähteenvuo, Markku, additional, Lahdensuo, Kaisla, additional, Kerkelä, Martta, additional, Ahola-Olli, Ari, additional, Hietala, Jarmo, additional, Kampman, Olli, additional, Kieseppä, Tuula, additional, Jukuri, Tuomas, additional, Häkkinen, Katja, additional, Cederlöf, Erik, additional, Haaki, Willehard, additional, Kajanne, Risto, additional, Wegelius, Asko, additional, Männynsalo, Teemu, additional, Niemi-Pynttäri, Jussi, additional, Suokas, Kimmo, additional, Lönnqvist, Jouko, additional, Tiihonen, Jari, additional, Paunio, Tiina, additional, Vainio, Seppo Juhani, additional, Palotie, Aarno, additional, Niemelä, Solja, additional, Suvisaari, Jaana, additional, and Veijola, Juha, additional
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- 2021
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22. Cognitive functioning and cannabis use in first-episode psychosis.
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Karpov, Boris, Lindgren, Maija, Kieseppä, Tuula, Wegelius, Asko, and Suvisaari, Jaana
- Subjects
GENERAL factor (Psychology) ,COGNITIVE ability ,PSYCHIATRIC rating scales ,PSYCHOSES - Abstract
Cannabis use is common in people with psychotic disorders. However, the effect of cannabis on cognition in psychosis remains unclear. Our study investigates relationships between the history of cannabis use and cognitive performance in patients with first-episode psychosis (FEP) during a one-year follow-up. The present study included FEP (N = 91) and control (N = 61) groups. Cannabis use was evaluated with a self-report questionnaire, clinical assessment, and medical records during a lifetime and 12 months prior to the treatment onset (recent). Symptoms of psychosis and anxiety were evaluated on the brief psychiatric rating scale. Negative symptoms were assessed using the scale for the assessment of negative symptoms. Cognitive tests were used to evaluate neurocognition (summarized in the g factor) and social cognition. Crude regression analyses for the g factor included variables of cannabis use as independent variables. Full regression models were controlled for gender, education, and clinical symptoms. In the FEP group, men used cannabis more frequently than women. In the crude regression model for FEP patients, never having used cannabis was associated with a better neurocognitive profile at 12 months. In the full model, more severe anxiety symptoms were associated with better neurocognition at two months, and less severe negative symptoms were associated with better neurocognition at 12 months. Cannabis use was not associated with social cognition. No associations between cognitive performance and cannabis use emerged in the controls. Negative and affective symptom severity in FEP was associated with cognitive performance to a greater degree than a lifetime history of cannabis use. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
23. Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder
- Author
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Mazumder, Atiqul Haq, primary, Barnett, Jennifer, additional, Lindberg, Nina, additional, Torniainen-Holm, Minna, additional, Lähteenvuo, Markku, additional, Lahdensuo, Kaisla, additional, Kerkelä, Martta, additional, Hietala, Jarmo, additional, Isometsä, Erkki Tapio, additional, Kampman, Olli, additional, Kieseppä, Tuula, additional, Jukuri, Tuomas, additional, Häkkinen, Katja, additional, Cederlöf, Erik, additional, Haaki, Willehard, additional, Kajanne, Risto, additional, Wegelius, Asko, additional, Männynsalo, Teemu, additional, Niemi-Pynttäri, Jussi, additional, Suokas, Kimmo, additional, Lönnqvist, Jouko, additional, Niemelä, Solja, additional, Tiihonen, Jari, additional, Paunio, Tiina, additional, Palotie, Aarno, additional, Suvisaari, Jaana, additional, and Veijola, Juha, additional
- Published
- 2021
- Full Text
- View/download PDF
24. Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder
- Author
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Mazumder, Atiqul Haq, Barnett, Jennifer, Isometsä, Erkki Tapio, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Ahola-Olli, Ari, Hietala, Jarmo, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Tiihonen, Jari, Paunio, Tiina, Vainio, Seppo Juhani, Palotie, Aarno, Niemelä, Solja, Suvisaari, Jaana, Veijola, Juha, Tampere University, Department of Psychotic Disorders, and Clinical Medicine
- Subjects
3124 Neurology and psychiatry - Abstract
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder. publishedVersion
- Published
- 2021
25. Reaction Time and Visual Memory in Connection to Alcohol Use In Schizophrenia and Schizoaffective Disorder
- Author
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Mazumder, Atiqul Haq, primary, Barnett, Jennifer, additional, Lindberg, Nina, additional, Torniainen-Holm, Minna, additional, Lähteenvuo, Markku, additional, Lahdensuo, Kaisla, additional, Kerkelä, Martta, additional, Hietala, Jarmo, additional, Isometsä, Erkki, additional, Kampman, Olli, additional, Kieseppä, Tuula, additional, Jukuri, Tuomas, additional, Häkkinen, Katja, additional, Cederlöf, Erik, additional, Haaki, Willehard, additional, Kajanne, Risto, additional, Wegelius, Asko, additional, Männynsalo, Teemu, additional, Niemi-Pynttäri, Jussi, additional, Suokas, Kimmo, additional, Lönnqvist, Jouko, additional, Niemelä, Solja, additional, Tiihonen, Jari, additional, Paunio, Tiina, additional, Tuulio-Henriksson, Annamari, additional, Palotie, Aarno, additional, Suvisaari, Jaana, additional, and Veijola, Juha, additional
- Published
- 2021
- Full Text
- View/download PDF
26. Anxiety symptoms in first‐episode psychosis
- Author
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Karpov, Boris, primary, Kieseppä, Tuula, additional, Lindgren, Maija, additional, Wegelius, Asko, additional, and Suvisaari, Jaana, additional
- Published
- 2020
- Full Text
- View/download PDF
27. Implementation of CYP2D6copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder
- Author
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Häkkinen, Katja, Kiiski, Johanna I., Lähteenvuo, Markku, Jukuri, Tuomas, Suokas, Kimmo, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Lahdensuo, Kaisla, Kajanne, Risto, Kaunisto, Mari A., Tuulio-Henriksson, Annamari, Kampman, Olli, Hietala, Jarmo, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Paunio, Tiina, Suvisaari, Jaana, Kalso, Eija, Niemi, Mikko, Tiihonen, Jari, Daly, Mark, Palotie, Aarno, and Ahola-Olli, Ari V.
- Abstract
We demonstrate that CYP2D6copy-number variation (CNV) can be imputed using existing imputation algorithms. Additionally, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genetically bottle-necked population of Finland. We combined GWAS chip and CYP2D6CNV data from the Breast Cancer Pain Genetics study to construct an imputation panel (n= 902) for CYP2D6CNV. The resulting data set was used as a CYP2D6CNV imputation panel in 9262 non-related individuals from the SUPER-Finland study. Based on imputation of 9262 individuals we confirm the higher frequency of CYP2D6 ultrarapid metabolizers and a 22-fold enrichment of the UGT1A1decreased function variant rs4148323 (UGT1A1*6) in Finland compared with non-Finnish Europeans. Similarly, the NUDT15variant rs116855232 was highly enriched in Finland. We demonstrate that imputation of CYP2D6CNV is possible and the methodology enables studying CYP2D6in large biobanks with genome-wide data.
- Published
- 2022
- Full Text
- View/download PDF
28. Anxiety symptoms in first‐episode psychosis.
- Author
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Karpov, Boris, Kieseppä, Tuula, Lindgren, Maija, Wegelius, Asko, and Suvisaari, Jaana
- Subjects
PSYCHIATRIC rating scales ,ANXIETY ,DISEASE remission - Abstract
Aim: Anxiety disorders and symptoms are common in people with psychotic disorders, having a negative impact on clinical status, function level and overall prognosis. However, research on the significance of anxiety in predicting remission and long‐term functioning in first‐episode psychosis (FEP) is still scarce. This study investigated the effects of anxiety and obsessive‐compulsive symptoms (OCS) on clinical and functional improvement in individuals with FEP. Methods: FEP patients (N = 97) aged 18‐40 years were recruited from the University Hospital District of Helsinki and the City of Helsinki. Psychotic and anxiety symptoms were measured using the Brief Psychiatric Rating Scale. Obsessive‐compulsive symptoms were assessed using the Obsessive‐Compulsive Inventory (OCI‐R), and functioning was evaluated using the Social and Occupational Functioning Assessment Scale (SOFAS). Follow‐up measurements were performed at 2 and 12 months. We specifically studied whether anxiety and obsessive‐compulsive symptoms at the 2‐month follow‐up assessment, at a time when the initial treatment response had been achieved, would predict outcomes at 12 months. Results: Symptoms of anxiety and OCS correlated moderately with each other and psychotic symptoms, but at the 12‐month follow‐up, OCS no longer correlated significantly with psychotic and anxiety symptoms. When the level of psychotic symptoms was adjusted for, more severe OCS at the 2‐month follow‐up was associated with a lower rate of remission at 12 months, whereas a higher level of anxiety symptoms at 2 months was associated with better functioning at 12 months. Conclusions: OCS may be predictive of poorer clinical outcomes, whereas anxiety symptoms may predict better functional outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
29. Influence of birth weight on the risk and clinical presentation of schizophrenia
- Author
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Wegelius, Asko, University of Helsinki, Faculty of Medicine, Clinicum, Department of Psychiatry, National Institute for Health and Welfare, Mental Health Unit, Helsingin yliopisto, lääketieteellinen tiedekunta, Clinicum, Helsingfors universitet, medicinska fakulteten, Clinicum, Korkeila, Jyrki, Suvisaari, Jaana, and Paunio, Tiina
- Subjects
lääketiede, Psykiatria - Abstract
Pre- and perinatal environmental factors have been associated with increased schizophrenia risk, particularly in combination with genetic liability. Both low and high birth weight have been associated with an increased risk of autism spectrum disorders and schizophrenia. The interaction of specific schizophrenia susceptibility genes and specified pre- and perinatal environmental factors have recently been described in relation to augmented schizophrenia risk. In this thesis, the relationship between birth weight and schizophrenia risk was investigated as part of a large Finnish schizophrenia family study sample based on the Genetic Epidemiology and Molecular Genetics of Schizophrenia in Finland study, in which genetic susceptibility for schizophrenia is known to be elevated relative to the general population (Study I). The study sample consisted of two subsamples having at least one sibling with a diagnosis of schizophrenia. The associations between birth weight and symptom severity of schizophrenia and psychotic disorders (Study II) and cognitive functioning in schizophrenia (Study III) were also characterized. A gene-environment interaction, focusing on birth weight and specific genes from the DISC1 network (Study IV), which had previously been found to be associated with increased schizophrenia risk in the same cohort, was also investigated in relation to schizophrenia risk. A 1.68-fold increase in schizophrenia risk was observed in subjects presenting with a high birth weight (>4000 g) relative to subjects with an intermediate birth weight of 3000-4000 g (Study I). In particular, schizophrenia risk was elevated among high birth weight individuals in combination with specific variants of the NDE1 gene (Study IV). Both low and high birth weight were found to be associated with increased severity of disorganized and negative symptom dimensions, whereas birth weight was not associated with symptoms of reality distortion (Study II). Both low and high birth weight, compared with the intermediate birth weight range, were associated with a slight decrease in cognitive performance among both subjects with schizophrenia and their unaffected first-degree relatives (Study III). The observations in the thesis corroborate existing findings describing an association between high birth weight and increased schizophrenia risk. An association between low birth weight and increased schizophrenia risk, a finding widely documented in the literature, was not seen here. Birth weight was found to influence both symptom severity and cognitive performance in schizophrenia. The findings also suggest that the functions of NDE1 during the early stages of neurodevelopment are vulnerable to the influence of pre- and perinatal environmental factors associated with high birth weight, with the propensity to augment subsequent schizophrenia susceptibility among offspring. The mechanisms underlying the association between high birth weight and schizophrenia risk are speculative, but may involve factors such as pre- or perinatal hypoxia, maternal metabolic and immunological mechanisms during pregnancy. Graviditets- och förlossningsfaktorer påverkar vår predisposition för schizofreni, framför allt i kombination med ett ärftligt anlag för sjukdomen. I denna doktorsavhandling undersöks sambandet mellan födelsevikten och risken för att utveckla schizofreni samt schizofrenisjukdomens kliniska symtombild i finländska familjer med ett känt anlag för schizofreni. Avhandlingen undersöker även hur DISC1-genvarianter, som deltar i utvecklingen av det centrala nervsystemet, tillsammans med födelsevikten påverkar predispositionen för schizofreni. Doktorsavhandlingen är en del av forskningsprojektet Genetisk epidemiologi och molekylärgenetisk bakgrund vid allvarliga psykiska störningar i regi av Institutet för hälsa och välfärd. Undersökningen påvisade förhöjd predisposition för schizofreni hos individer med hög födelsevikt (> 4000 g). Dessutom upptäcktes ett samband mellan hög och låg födelsevikt å ena sidan och svårare symtombild och en lägre kognitiv kapacitet å andra sidan, i jämförelse med normal födelsevikt. Förhöjd predisposition för schizofreni förelåg framför allt hos individer med vissa NDE1-genvarianter av DISC1-gentypen och hög födelsevikt. Födelsevikten anses avspegla graviditets- och förlossningsmiljöns inverkan på det växande fostret. Dessa forskningsrön stödjer uppfattningen om att födelsevikten har ett samband med utvecklingen av det centrala nervsystemet och med en förhöjd disposition för schizofreni samt bl.a. att NDE1-genen påverkas av graviditets- och förlossningsfaktorer. Även om denna avhandling inte undersökte de direkta förklaringarna bakom dessa observationer är det känt att födelsevikten har ett samband med metabola och immunologiska faktorer hos modern under graviditeten samt med syrebrist hos barnet i samband med förlossning. Detta är så vitt det är känt den mest omfattande undersökningen av sambanden mellan födelsevikten och en genetisk predisposition för schizofreni och det är en ny upptäckt att samspelet mellan graviditets- och förlossningsfaktorer och genen som deltar i utvecklingen av det centrala nervsystemet innebär en förhöjd predisposition för schizofreni. Dessa resultat bidrar till en ökad förståelse av schizofrenisjukdomens långsiktiga natur och utveckling där predisponerande biologiska faktorer för schizofreni aktiveras i ett mycket tidigt utvecklingsstadium. Dessa forskningsrön väcker frågor om huruvida graviditets- och förlossningsfaktorer bör uppmärksammas mer som en del av utvecklingen av mödra- och barnrådgivningsverksamheten för psykiatriska riskgrupper. Genetisk forskning kommer i framtiden att bidra med ökad kunskap om biologiska riskfaktorer för psykiatriska sjukdomar samtidigt som forskningen erbjuder utökade möjligheter för att undersöka sambanden mellan de genetiska och miljömässiga faktorer som ger upphov till psykiatriska sjukdomar.
- Published
- 2017
30. O5.5. SLEEP IN MAJOR PSYCHIATRIC DISORDERS: RESULTS FROM NATIONWIDE SUPER FINLAND STUDY
- Author
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Torniainen-Holm, Minna, primary, Cederlöf, Erik, additional, Haaki, Willehard, additional, Hietala, Jarmo, additional, Häkkinen, Katja, additional, Isometsä, Erkki, additional, Joutsenniemi, Kaisla, additional, Jukuri, Tuomas, additional, Kajanne, Risto, additional, Kampman, Olli, additional, Kieseppä, Tuula, additional, Lindberg, Nina, additional, Lähteenvuo, Markku, additional, Lönnqvist, Jouko, additional, Männynsalo, Teemu, additional, Niemi-Pynttäri, Jussi, additional, Suokas, Kimmo, additional, Suvisaari, Jaana, additional, Tiihonen, Jari, additional, Tuulio-Henriksson, Annamari, additional, Wegelius, Asko, additional, Veijola, Juha, additional, Palotie, Aarno, additional, and Paunio, Tiina, additional
- Published
- 2018
- Full Text
- View/download PDF
31. S56. PHOENIX GROUP, A PROJECT TO PREVENT RELAPSES IN SCHIZOPHRENIA
- Author
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Chiramberro, Marcelo, primary, Kieseppä, Tuula, additional, Wegelius, Asko, additional, Töhönen, Tuomo, additional, Ilvonen, Jenna, additional, Väisänen, Heli, additional, Sarkkinen, Katja, additional, Tikkala, Jenni, additional, Leiponen, Marita, additional, Ruppa, Markku, additional, Hyytiäinen, Matias, additional, Hynninen-Sundelin, Ira, additional, and Anttonen, Esa, additional
- Published
- 2018
- Full Text
- View/download PDF
32. An interaction between NDE1 and high birth weight increases schizophrenia susceptibility
- Author
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University of Helsinki, Clinicum, University of Helsinki, Hjelt Institute, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Wegelius, Asko, Pankakoski, Maiju, Tomppo, Liisa, Lehto, Ulriika, Lonnqvist, Jouko, Suvisaari, Jaana, Paunio, Tiina, Hennah, William, University of Helsinki, Clinicum, University of Helsinki, Hjelt Institute, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Wegelius, Asko, Pankakoski, Maiju, Tomppo, Liisa, Lehto, Ulriika, Lonnqvist, Jouko, Suvisaari, Jaana, Paunio, Tiina, and Hennah, William
- Abstract
Pre- and perinatal environmental factors have been shown to increase schizophrenia risk particularly when combined with genetic liability. The investigation of specific gene environment interactions in the etiology of psychiatric disorders has gained momentum. We used multivariate GEE regression modeling to investigate the interaction between genes of the DISCI pathway and birth weight, in relation to schizophrenia susceptibility in a Finnish schizophrenia family cohort. The study sample consisted of 457 subjects with both genotype and birth weight information. Gender and place of birth were adjusted for in the models. We found a significant interaction between birth weight and two NDE1 markers in relation to increased schizophrenia risk: a four SNP haplotype spanning NDE1 (b = 1.26, SE= 0.5, p = 0.012) and one of its constituent SNPs rs4781678 (b = 1.33, SE = 0.51, p = 0.010). Specifically, high birth weight (> 4000 g) was associated with increased schizophrenia risk among subjects homozygous for the previously identified risk alleles. The study was based on a family study sample with high genetic loading for schizophrenia and thus our findings cannot directly be generalized as representing the general population. Our results suggest that the functions mediated by NDE1 during the early stages of neurodevelopment are susceptible to the additional disruptive effects of pre- and perinatal environmental factors associated with high birth weight, augmenting schizophrenia susceptibility. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
- Published
- 2015
33. Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder
- Author
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Mazumder, Atiqul Haq, Barnett, Jennifer, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Hietala, Jarmo, Isometsä, Erkki Tapio, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Niemelä, Solja, Tiihonen, Jari, Paunio, Tiina, Palotie, Aarno, Suvisaari, Jaana, and Veijola, Juha
- Subjects
cognition ,reaction time ,schizophrenia ,alcohol ,schizoaffective disorder ,visual memory ,3. Good health - Abstract
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.
34. Cognitive functioning and cannabis use in first-episode psychosis
- Author
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Karpov, Boris, Lindgren, Maija, Kieseppä, Tuula, Wegelius, Asko, and Suvisaari, Jaana
- Subjects
3. Good health - Abstract
Cannabis use is common in people with psychotic disorders. However, the effect of cannabis on cognition in psychosis remains unclear. Our study investigates relationships between the history of cannabis use and cognitive performance in patients with first-episode psychosis (FEP) during a one-year follow-up. The present study included FEP (N = 91) and control (N = 61) groups. Cannabis use was evaluated with a self-report questionnaire, clinical assessment, and medical records during a lifetime and 12 months prior to the treatment onset (recent). Symptoms of psychosis and anxiety were evaluated on the brief psychiatric rating scale. Negative symptoms were assessed using the scale for the assessment of negative symptoms. Cognitive tests were used to evaluate neurocognition (summarized in the g factor) and social cognition. Crude regression analyses for the g factor included variables of cannabis use as independent variables. Full regression models were controlled for gender, education, and clinical symptoms. In the FEP group, men used cannabis more frequently than women. In the crude regression model for FEP patients, never having used cannabis was associated with a better neurocognitive profile at 12 months. In the full model, more severe anxiety symptoms were associated with better neurocognition at two months, and less severe negative symptoms were associated with better neurocognition at 12 months. Cannabis use was not associated with social cognition. No associations between cognitive performance and cannabis use emerged in the controls. Negative and affective symptom severity in FEP was associated with cognitive performance to a greater degree than a lifetime history of cannabis use.
35. Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder
- Author
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Mazumder, Atiqul Haq, Barnett, Jennifer, Isomets��, Erkki Tapio, Lindberg, Nina, Torniainen-Holm, Minna, L��hteenvuo, Markku, Lahdensuo, Kaisla, Kerkel��, Martta, Ahola-Olli, Ari, Hietala, Jarmo, Kampman, Olli, Kiesepp��, Tuula, Jukuri, Tuomas, H��kkinen, Katja, Cederl��f, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, M��nnynsalo, Teemu, Niemi-Pyntt��ri, Jussi, Suokas, Kimmo, L��nnqvist, Jouko, Tiihonen, Jari, Paunio, Tiina, Vainio, Seppo Juhani, Palotie, Aarno, Niemel��, Solja, Suvisaari, Jaana, and Veijola, Juha
- Subjects
Reaction time ,Visual Memory ,Cognition ,Bipolar disorder ,Alcohol ,3. Good health - Abstract
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder. Alcohol use was assessed through hazardous drinking and alcohol-related disorder including alcohol use disorder (AUD). Hazardous drinking was screened with the Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) screening tool. Alcohol-related disorder diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on A tablet computer: the 5-choice serial reaction time task, or reaction time (RT) test and the Paired Associative Learning (PAL) test. Depressive symptoms were assessed with the Mental Health Inventory with five items (MHI-5). However, no assessment of current manic symptoms was available. Association between RT-test and alcohol use was analyzed with log-linear regression, and e�� with 95% confidence intervals (CI) are reported. PAL first trial memory score was analyzed with linear regression, and �� with 95% CI are reported. PAL total errors adjusted was analyzed with logistic regression and odds ratios (OR) with 95% CI are reported. After adjustment of age, education, housing status and depression, hazardous drinking was associated with lower median and less variable RT in females while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores in females. Our findings of positive associations between alcohol use and cognition in persons with bipolar disorder are difficult to explain because of the methodological flaw of not being able to separately assess only participants in euthymic phase.
36. Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder
- Author
-
Mazumder, Atiqul Haq, Barnett, Jennifer, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Hietala, Jarmo, Isometsä, Erkki Tapio, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Niemelä, Solja, Tiihonen, Jari, Paunio, Tiina, Palotie, Aarno, Suvisaari, Jaana, and Veijola, Juha
- Subjects
Reaction time ,Visual Memory ,Cognition ,Schizoaffective Disorder ,Schizophrenia ,Alcohol ,3. Good health - Abstract
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.
37. Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder
- Author
-
Mazumder, Atiqul Haq, Barnett, Jennifer, Isometsä, Erkki Tapio, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Ahola-Olli, Ari, Hietala, Jarmo, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Tiihonen, Jari, Paunio, Tiina, Vainio, Seppo Juhani, Palotie, Aarno, Niemelä, Solja, Suvisaari, Jaana, and Veijola, Juha
- Subjects
cognition ,reaction time ,bipolar disorder ,alcohol ,visual memory ,3. Good health - Abstract
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder. Alcohol use was assessed through hazardous drinking and alcohol-related disorder including alcohol use disorder (AUD). Hazardous drinking was screened with the Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) screening tool. Alcohol-related disorder diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on A tablet computer: the 5-choice serial reaction time task, or reaction time (RT) test and the Paired Associative Learning (PAL) test. Depressive symptoms were assessed with the Mental Health Inventory with five items (MHI-5). However, no assessment of current manic symptoms was available. Association between RT-test and alcohol use was analyzed with log-linear regression, and eβ with 95% confidence intervals (CI) are reported. PAL first trial memory score was analyzed with linear regression, and β with 95% CI are reported. PAL total errors adjusted was analyzed with logistic regression and odds ratios (OR) with 95% CI are reported. After adjustment of age, education, housing status and depression, hazardous drinking was associated with lower median and less variable RT in females while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores in females. Our findings of positive associations between alcohol use and cognition in persons with bipolar disorder are difficult to explain because of the methodological flaw of not being able to separately assess only participants in euthymic phase.
38. Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder
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Mazumder, Atiqul Haq, Barnett, Jennifer, Isometsä, Erkki Tapio, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Ahola-Olli, Ari, Hietala, Jarmo, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Tiihonen, Jari, Paunio, Tiina, Vainio, Seppo Juhani, Palotie, Aarno, Niemelä, Solja, Suvisaari, Jaana, and Veijola, Juha
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bipolar disorder ,cognition ,reaction time ,alcohol ,visual memory ,3. Good health - Abstract
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder. Alcohol use was assessed through hazardous drinking and alcohol-related disorder including alcohol use disorder (AUD). Hazardous drinking was screened with the Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) screening tool. Alcohol-related disorder diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on A tablet computer: the 5-choice serial reaction time task, or reaction time (RT) test and the Paired Associative Learning (PAL) test. Depressive symptoms were assessed with the Mental Health Inventory with five items (MHI-5). However, no assessment of current manic symptoms was available. Association between RT-test and alcohol use was analyzed with log-linear regression, and eβ with 95% confidence intervals (CI) are reported. PAL first trial memory score was analyzed with linear regression, and β with 95% CI are reported. PAL total errors adjusted was analyzed with logistic regression and odds ratios (OR) with 95% CI are reported. After adjustment of age, education, housing status and depression, hazardous drinking was associated with lower median and less variable RT in females while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores in females. Our findings of positive associations between alcohol use and cognition in persons with bipolar disorder are difficult to explain because of the methodological flaw of not being able to separately assess only participants in euthymic phase.
39. Cognitive functioning and cannabis use in first-episode psychosis
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Karpov, Boris, Lindgren, Maija, Kieseppä, Tuula, Wegelius, Asko, and Suvisaari, Jaana
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3. Good health - Abstract
Cannabis use is common in people with psychotic disorders. However, the effect of cannabis on cognition in psychosis remains unclear. Our study investigates relationships between the history of cannabis use and cognitive performance in patients with first-episode psychosis (FEP) during a one-year follow-up. The present study included FEP (N = 91) and control (N = 61) groups. Cannabis use was evaluated with a self-report questionnaire, clinical assessment, and medical records during a lifetime and 12 months prior to the treatment onset (recent). Symptoms of psychosis and anxiety were evaluated on the brief psychiatric rating scale. Negative symptoms were assessed using the scale for the assessment of negative symptoms. Cognitive tests were used to evaluate neurocognition (summarized in the g factor) and social cognition. Crude regression analyses for the g factor included variables of cannabis use as independent variables. Full regression models were controlled for gender, education, and clinical symptoms. In the FEP group, men used cannabis more frequently than women. In the crude regression model for FEP patients, never having used cannabis was associated with a better neurocognitive profile at 12 months. In the full model, more severe anxiety symptoms were associated with better neurocognition at two months, and less severe negative symptoms were associated with better neurocognition at 12 months. Cannabis use was not associated with social cognition. No associations between cognitive performance and cannabis use emerged in the controls. Negative and affective symptom severity in FEP was associated with cognitive performance to a greater degree than a lifetime history of cannabis use.
40. Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder
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Mazumder, Atiqul Haq, Barnett, Jennifer, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Hietala, Jarmo, Isometsä, Erkki, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Niemelä, Solja, Tiihonen, Jari, Paunio, Tiina, Palotie, Aarno, Suvisaari, Jaana, and Veijola, Juha
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cognition ,reaction time ,schizophrenia ,alcohol ,visual memory ,schizoaffective disorder ,3. Good health - Abstract
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.
41. Cognitive behavioural therapy for insomnia (CBT-I) in schizophrenia and schizoaffective disorder: protocol for a randomised controlled trial.
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Tanskanen TE, Wegelius A, Härkönen T, Gummerus EM, Stenberg JH, Selinheimo SIK, Alakuijala A, Tenhunen M, Paajanen T, Järnefelt H, Kajaste S, Blom K, Kieseppä T, Tuisku K, and Paunio T
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- Humans, Randomized Controlled Trials as Topic, Adult, Female, Male, Finland, Sleep Initiation and Maintenance Disorders therapy, Sleep Initiation and Maintenance Disorders etiology, Cognitive Behavioral Therapy methods, Schizophrenia therapy, Schizophrenia complications, Psychotic Disorders therapy, Psychotic Disorders complications, Quality of Life
- Abstract
Introduction: Insomnia is a common symptom among patients with schizophrenia and schizoaffective disorder, negatively impacting symptom severity, functioning and well-being; however, it is rarely the direct focus of treatment. The main recommended treatment for insomnia is cognitive behavioural therapy (CBT-I). There is some evidence that CBT-I can also be used to treat insomnia in patients with schizophrenia, but only a few randomised controlled trials (RCTs) have been published. The aim of this ongoing RCT is to determine whether we can alleviate symptoms of insomnia and improve the quality of life in patients with schizophrenia and schizoaffective disorder through CBT-I delivered via the internet or in a group mode., Methods and Analyses: The aim of this study is to recruit 84-120 outpatients from the Psychosis Clinics of Helsinki University Hospital and the City of Helsinki Health Services. The main inclusion criteria are a diagnosis of schizophrenia or schizoaffective disorder and self-reported sleep problems. The study will be performed on a cyclic basis, with a target of 12-24 patients per cycle. Participants are randomly assigned into three groups: (1) a group receiving only treatment as usual (TAU), (2) internet-based individual therapy for insomnia (iCBT-I)+TAU or (3) group therapy for insomnia (GCBT-I) conducted via a virtual platform+TAU. The primary outcome measures are quantitative changes in the Insomnia Severity Index score and/or changes in health-related quality of life using the 15D quality of life measure. Secondary outcomes include self-reported variables for sleep, health, stress and the severity of psychotic and depressive symptoms; objective outcomes include actigraphy and bed sensor data to evaluate circadian rhythms and motor activity. Outcome measures are assessed at baseline and after the treatment period at weeks 12, 24 and 36., Ethics and Dissemination: The Coordinating Ethics Committee of the Hospital District of Helsinki and Uusimaa, Finland, approved the study protocol. The results will be published in peer-reviewed journals., Trial Registration Number: NCT04144231., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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42. Antipsychotic medications and sleep problems in patients with schizophrenia.
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Cederlöf E, Holm M, Taipale H, Tiihonen J, Tanskanen A, Lähteenvuo M, Lahdensuo K, Kampman O, Wegelius A, Isometsä E, Kieseppä T, Palotie A, Suvisaari J, and Paunio T
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- Humans, Male, Female, Adult, Middle Aged, Finland epidemiology, Aripiprazole adverse effects, Aripiprazole administration & dosage, Schizophrenia drug therapy, Schizophrenia complications, Schizophrenia epidemiology, Antipsychotic Agents adverse effects, Sleep Wake Disorders chemically induced, Sleep Wake Disorders epidemiology
- Abstract
Background: Sleep problems are common and related to a worse quality of life in patients with schizophrenia. Almost all patients with schizophrenia use antipsychotic medications, which usually increase sleep. Still, the differences in subjective sleep outcomes between different antipsychotic medications are not entirely clear., Methods: This study assessed 5466 patients with schizophrenia and is part of the nationwide Finnish SUPER study. We examined how the five most common antipsychotic medications (clozapine, olanzapine, quetiapine, aripiprazole, and risperidone) associate with questionnaire-based sleep problems in logistic regression analyses, including head-to-head analyses between different antipsychotic medications. The sleep problems were difficulties initiating sleep, early morning awakenings, fatigue, poor sleep quality, short (≤6 h) and long sleep duration (≥10 h)., Results: The average number of antipsychotic medications was 1.59 per patient. Clozapine was associated with long sleep duration (49.0 % of clozapine users vs 30.2 % of other patients, OR = 2.05, 95 % CI 1.83-2.30, p < .001). Olanzapine and risperidone were in head-to-head analyses associated with less sleep problems than patients using aripiprazole, quetiapine, or no antipsychotic medication. Aripiprazole and quetiapine were associated with more insomnia symptoms and poorer sleep quality. Patients without antipsychotic medications (N = 159) had poorer sleep quality than patients with antipsychotic use, and short sleep duration was common (21.5 % of patients not using antipsychotics vs 7.8 % of patients using antipsychotics, OR = 2.97, 95 % CI 1.98-4.44, p < .001)., Conclusions: Prevalence of sleep problems is markedly related to the antipsychotic medication the patient uses. These findings underline the importance of considering and assessing sleep problems when treating schizophrenia patients with antipsychotics., Competing Interests: Declaration of competing interest Regarding conflicts of interest, Markku Lähteenvuo is an owner and board member of Genomi Solutions Ltd. and Nursie Health Ltd. and has received honoraria from Sunovion, Orion Pharma, Janssen-Cilag, Otsuka Pharma, Lundbeck, and Medscape, travel funds from Sunovion, and research grants from the Finnish Medical Foundation, the Emil Aaltonen Foundation, and the Finnish Cultural Foundation. Jari Tiihonen has participated in research projects funded by grants from Janssen-Cilag and Eli Lilly to their employing institution; has received personal fees from the Finnish Medicines Agency (Fimea), European Medicines Agency (EMA), Eli Lilly, Janssen-Cilag, Lundbeck, and Otsuka; is a member of the advisory board for Lundbeck; and has received grants from the Stanley Foundation and the Sigrid Jusélius Foundation. None of the other authors report any financial relationships with commercial interests., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2024
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43. Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.
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Mazumder AH, Barnett J, Isometsä ET, Lindberg N, Torniainen-Holm M, Lähteenvuo M, Lahdensuo K, Kerkelä M, Ahola-Olli A, Hietala J, Kampman O, Kieseppä T, Jukuri T, Häkkinen K, Cederlöf E, Haaki W, Kajanne R, Wegelius A, Männynsalo T, Niemi-Pynttäri J, Suokas K, Lönnqvist J, Tiihonen J, Paunio T, Vainio SJ, Palotie A, Niemelä S, Suvisaari J, and Veijola J
- Abstract
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
- Published
- 2021
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