Search

Your search keyword '"Weerasooriya C"' showing total 3 results
Start Over Author "Weerasooriya C"
3 results on '"Weerasooriya C"'

1. Dynamics of the hysteretic voltage-induced torsional strain in tantalum trisulfide

Author

Nichols, J., Weerasooriya, C. Sandamali, and Brill, J. W.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We have studied how the hysteretic voltage-induced torsional strain, associated with charge-density-wave depinning, in orthorhombic tantalum trisulfide depends on square-wave and triangle-wave voltages of different frequencies and amplitudes. The strains are measured by placing the sample, with a wire glued to the center as a transducer, in a radio frequency cavity and measuring the modulated response of the cavity. From the triangle waves, we map out the time dependence of the hysteresis loops, and find that the hysteresis loops broaden for waves with periods less than 30 seconds. The square-wave response shows that the dynamic response to positive and negative voltages can be quite different. The overall frequency dependence is relaxational, but with multiple relaxation times which typically decrease with increasing voltage. The detailed dynamic response is very sample dependent, suggesting that it depends in detail on interactions of the CDW with sample defects., Comment: 13 pages, 6 figures, to be published in Journal of Physics: Cond. Matt

Published
2009
Full Text
View/download PDF

3. Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation.

Author

Suciu RM, Luvaga IK, Hazeen A, Weerasooriya C, Richardson SK, Firestone AJ, Shannon K, Howell AR, and Cravatt BF

Subjects
Humans, Lactones metabolism, Lactones pharmacology, Molecular Structure, Propiolactone analysis, Propiolactone metabolism, Propiolactone pharmacology, Sulfones metabolism, Sulfones pharmacology, ras Proteins antagonists & inhibitors, ras Proteins chemistry, Lactones analysis, Propiolactone analogs & derivatives, Proteomics, Sulfones analysis, ras Proteins metabolism
Abstract

S-Palmitoylation is a reversible post-translational lipid modification that regulates protein trafficking and signaling. The enzymatic depalmitoylation of proteins is inhibited by the beta-lactones Palmostatin M and B, which have been found to target several serine hydrolases. In efforts to better understand the mechanism of action of Palmostatin M, we describe herein the synthesis, chemical proteomic analysis, and functional characterization of analogs of this compound. We identify Palmostatin M analogs that maintain inhibitory activity in N-Ras depalmitoylation assays while displaying complementary reactivity across the serine hydrolase class as measured by activity-based protein profiling. Active Palmostatin M analogs inhibit the recently characterized ABHD17 subfamily of depalmitoylating enzymes, while sparing other candidate depalmitoylases such as LYPLA1 and LYPLA2. These findings improve our understanding of the structure-activity relationship of Palmostatin M and refine the set of serine hydrolase targets relevant to the compound's effects on N-Ras palmitoylation dynamics., (Copyright © 2021. Published by Elsevier Ltd.)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results