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1. Novel transcriptomic signatures associated with premature kidney allograft failure

Author

Hruba, Petra, Klema, Jiri, Le, Anh Vu, Girmanova, Eva, Mrazova, Petra, Massart, Annick, Maixnerova, Dita, Voska, Ludek, Piredda, Gian Benedetto, Biancone, Luigi, Puga, Ana Ramirez, Seyahi, Nurhan, Sever, Mehmet Sukru, Weekers, Laurent, Muhfeld, Anja, Budde, Klemens, Watschinger, Bruno, Miglinas, Marius, Zahradka, Ivan, Abramowicz, Marc, Abramowicz, Daniel, and Viklicky, Ondrej

Published
2023
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2. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M., Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, and Bahram, Seiamak

Published
2022
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3. Allogeneic mesenchymal stromal cell therapy in kidney transplantation: should repeated human leukocyte antigen mismatches be avoided?

Author

Bezstarosti, Suzanne, Erpicum, Pauline, Maggipinto, Gianni, Dreyer, Geertje J., Reinders, Marlies E. J., Meziyerh, Soufian, Roelen, Dave L., De Fijter, Johan W., Kers, Jesper, Weekers, Laurent, Beguin, Yves, Jouret, François, and Heidt, Sebastiaan

Subjects
HLA histocompatibility antigens, AMINO acid analysis, HISTOCOMPATIBILITY antigens, KIDNEY transplantation, STROMAL cells
Abstract

Mesenchymal stromal cells (MSCs) have immunomodulatory properties and are therefore considered promising tools in kidney transplantation. Although most studies have been conducted with autologous MSCs, using allogeneic MSCs as an off-the-shelf product is more feasible in clinical settings. However, allogeneic MSCs could potentially induce an immune response, which might eventually be directed towards the kidney allograft because of shared human leukocyte antigen (HLA) epitope mismatches between the kidney and MSC donor. In this study, we performed in-depth analyses of two cohorts (n = 20) that received third-party MSC therapy after kidney transplantation. While the Neptune Study from Leiden University Medical Center specifically selected MSC to avoid repeated HLA antigen mismatches between kidney and MSC donors, the study from the University of Liège did not perform specific MSC selection. The comparative analyses of amino acid mismatches between these cohorts showed that MSC selection to avoid repeated HLA mismatches at the split antigen level was not sufficient to prevent repeated mismatches at the amino acid level. However, repeated amino acid mismatches were not associated with the occurrence of donor-specific antibodies (DSAs). Thus, the clinical relevance of repeated amino acid mismatches seems to be limited with regard to the risk of DSA formation. Since DSA formation was limited (3 of 20 patients) in this study, larger studies are required to investigate the relevance of preventing repeated HLA mismatches in allogeneic MSC therapy in kidney transplantation. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Antibiotics versus no therapy in kidney transplant recipients with asymptomatic bacteriuria (BiRT): a pragmatic, multicentre, randomized, controlled trial

Author

Beq, Audrey, Besse-Hammer, Tatiana, Blondel-Halley, Marie-Noëlle, Borsu, Arnaud, Charpy, Vianney, Couzi, Lionel, Debelle, Frédéric, Bello, Arnaud del, de Solere, Marie, Frade, Sara, Frimat, Luc, Grimbert, Philippe, Guerif, Pierrick, Hellemans, Rachel, Hodemon-Corne, Bénédicte, Hougardy, Jean-Michel, Le Moine, Alain, Lietaer, Nicole, Lortholary, Olivier, Loudon, Kirsty, Massart, Annick, Meersman, Els, Ouk, Thavarak, Pipeleers, Lissa, Roisin, Sandrine, Tollot, Sarah, Verhofstede, Sabine, Wojcik, Martin, Coussement, Julien, Kamar, Nassim, Matignon, Marie, Weekers, Laurent, Scemla, Anne, Giral, Magali, Racapé, Judith, Alamartine, Éric, Mesnard, Laurent, Kianda, Mireille, Ghisdal, Lidia, Catalano, Concetta, Broeders, Emine N., Denis, Olivier, Wissing, Karl M., Hazzan, Marc, and Abramowicz, Daniel

Published
2021
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9. International comparison and time trends of first kidney transplant recipient characteristics across Europe: an ERA Registry study.

Author

Boenink, Rianne, Kramer, Anneke, Masoud, Sherry, Rodríguez-Benot, Alberto, Helve, Jaakko, Bistrup, Claus, Segelmark, Mårten M, Arévalo, Olga L Rodríguez, Kerschbaum, Julia, Vries, Aiko P J de, Lundgren, Torbjörn, Bell, Samira, Crespo, Marta, Sørensen, Søren S, Ferraro, Pietro Manuel, Arnol, Miha, Bakkaloglu, Sevcan A, Weekers, Laurent, Reisæter, Anna Varberg, and Rebić, Damir

Subjects
KIDNEY transplantation, AGE differences, AGE distribution, KIDNEY diseases, DIABETES
Abstract

Background The aim of this study was to provide an overview of age, sex and primary renal disease (PRD) distribution among first kidney transplant recipients across Europe. Method The European Renal Association (ERA) Registry database was used to obtain data on patients aged 20 years or older receiving their first kidney transplant between 2010 and 2019 from 12 European countries. The numbers and percentages of recipients in each age, sex and PRD group were calculated by country, donor type and year. Results In total, 99 543 adults received a first kidney transplant. Overall, 23% of the recipients were 65 years or older, 36% were female, and 21% had glomerulonephritis and 15% diabetes mellitus as PRD. Compared with deceased donor kidney transplant recipients, living donor kidney transplant recipients were less often 65 years or older (13% versus 26%), more often had glomerulonephritis (25% versus 20%) and less often diabetes mellitus (8% versus 17%) as PRD. We found large international differences, which were most prominent for age and PRD and less prominent for sex. Over time, the largest change in recipient characteristics was observed for the percentage of recipients aged 65 years or older, increasing from 18% in 2010 to 28% in 2019 for all countries combined with a similar trend in most countries. Conclusion We observed large differences for age and PRD distribution between recipients of living and deceased donor kidneys and between European countries. Over time, the percentage of older first kidney transplant recipients increased. [ABSTRACT FROM AUTHOR]

Published
2024
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11. International comparison and time trends of first kidney transplant recipient characteristics across Europe: an ERA Registry study

Author

Boenink, Rianne, primary, Kramer, Anneke, additional, Masoud, Sherry, additional, Rodríguez-Benot, Alberto, additional, Helve, Jaakko, additional, Bistrup, Claus, additional, Segelmark, Mårten M, additional, Rodríguez Arévalo, Olga L, additional, Kerschbaum, Julia, additional, de Vries, Aiko P J, additional, Lundgren, Torbjörn, additional, Bell, Samira, additional, Crespo, Marta, additional, Sørensen, Søren S, additional, Ferraro, Pietro Manuel, additional, Arnol, Miha, additional, Bakkaloglu, Sevcan A, additional, Weekers, Laurent, additional, Reisæter, Anna Varberg, additional, Rebić, Damir, additional, Ortiz, Alberto, additional, Jager, Kitty J, additional, and Stel, Vianda S, additional

Published
2023
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12. The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes

Author

Fank, Hélène, primary, Weekers, Laurent, additional, Lovinfosse, Pierre, additional, Pottel, Hans, additional, Seidel, Laurence, additional, Jadoul, Alexandre, additional, Bouquegneau, Antoine, additional, Bonvoisin, Catherine, additional, Bovy, Christophe, additional, Grosch, Stephanie, additional, Erpicum, Pauline, additional, Hustinx, Roland, additional, and Jouret, François, additional

Published
2023
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15. The Effect of Elective Ligation of the Arteriovenous Fistula on Cardiac and Renal Functions in Kidney Transplant Recipients

Author

Masson, Grégoire, primary, Viva, Tommaso, additional, Huart, Justine, additional, Weekers, Laurent, additional, Bonvoisin, Catherine, additional, Bouquegneau, Antoine, additional, Maweja, Sylvie, additional, Hamoir, Etienne, additional, Seidel, Laurence, additional, Pottel, Hans, additional, Lancellotti, Patrizio, additional, and Jouret, François, additional

Published
2023
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21. Age-adapted percentiles of measured glomerular filtration in healthy individuals : extrapolation to living kidney donors over 65 years.

Author

Delanaye, Pierre, Gaillard, François, van der Weijden, Jessica, Mjøen, Geir, Ferhman-Ekholm, Ingela, Dubourg, Laurence, Ebert, Natalie, Schaeffner, Elke, Åkerfeldt, Torbjörn, Goffin, Karolien, Couzi, Lionel, Garrouste, Cyril, Rostaing, Lionel, Courbebaisse, Marie, Legendre, Christophe, Hourmant, Maryvonne, Kamar, Nassim, Cavalier, Etienne, Weekers, Laurent, Bouquegneau, Antoine, de Borst, Martin H, Mariat, Christophe, Pottel, Hans, van Londen, Marco, Delanaye, Pierre, Gaillard, François, van der Weijden, Jessica, Mjøen, Geir, Ferhman-Ekholm, Ingela, Dubourg, Laurence, Ebert, Natalie, Schaeffner, Elke, Åkerfeldt, Torbjörn, Goffin, Karolien, Couzi, Lionel, Garrouste, Cyril, Rostaing, Lionel, Courbebaisse, Marie, Legendre, Christophe, Hourmant, Maryvonne, Kamar, Nassim, Cavalier, Etienne, Weekers, Laurent, Bouquegneau, Antoine, de Borst, Martin H, Mariat, Christophe, Pottel, Hans, and van Londen, Marco

Abstract

OBJECTIVES: Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we calculated percentiles of measured GFR (mGFR) in donors <65 years old and extrapolated these to donors ≥65 years old. METHODS: mGFR percentiles were calculated from a development cohort of French/Belgian living kidney donors <65 years (n=1,983), using quantiles modeled as cubic splines (two linear parts joining at 40 years). Percentiles were extrapolated and validated in an internal cohort of donors ≥65 years (n=147, France) and external cohort of donors and healthy subjects ≥65 years (n=329, Germany, Sweden, Norway, France, The Netherlands) by calculating percentages within the extrapolated 5th-95th percentile (P5-P95). RESULTS: Individuals in the development cohort had a higher mGFR (99.9 ± 16.4 vs. 86.4 ± 14 and 82.7 ± 15.5 mL/min/1.73 m2) compared to the individuals in the validation cohorts. In the internal validation cohort, none (0%) had mGFR below the extrapolated P5, 12 (8.2%) above P95 and 135 (91.8%) between P5-P95. In the external validation cohort, five subjects had mGFR below the extrapolated P5 (1.5%), 25 above P95 (7.6%) and 299 (90.9%) between P5-P95. CONCLUSIONS: We demonstrate that extrapolation of mGFR from younger donors is possible and might aid with decision-making in elderly donors.

Published
2022
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22. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

Süsal, Caner, Carapito, Raphael; Aouadi, Ismail; Verniquet, Martin; Untrau, Meiggie; Pichot, Angelique; Beaudrey, Thomas; Bassand, Xavier; Meyer, Sebastien; Faucher, Loic; Posson, Juliane; Morlon, Aurore; Kotova, Irina; Delbos, Florent; Walencik, Alexandre; Aarnink, Alice; Kennel, Anne; Suberbielle, Caroline; Taupin, Jean-Luc; Matern, Benedict M.; Spierings, Eric; Congy-Jolivet, Nicolas; Essaydi, Arnaud; Perrin, Peggy; Blancher, Antoine; Charron, Dominique; Cereb, Nezih; Maumy-Bertrand, Myriam; Bertrand, Frederic; Garrigue, Valerie; Pernin, Vincent; Weekers, Laurent; Naesens, Maarten; Kamar, Nassim; Legendre, Christophe; Glotz, Denis; Caillard, Sophie; Ladriere, Marc; Giral, Magali; Anglicheau, Dany; Bahram, Seiamak, School of Medicine, Süsal, Caner, Carapito, Raphael; Aouadi, Ismail; Verniquet, Martin; Untrau, Meiggie; Pichot, Angelique; Beaudrey, Thomas; Bassand, Xavier; Meyer, Sebastien; Faucher, Loic; Posson, Juliane; Morlon, Aurore; Kotova, Irina; Delbos, Florent; Walencik, Alexandre; Aarnink, Alice; Kennel, Anne; Suberbielle, Caroline; Taupin, Jean-Luc; Matern, Benedict M.; Spierings, Eric; Congy-Jolivet, Nicolas; Essaydi, Arnaud; Perrin, Peggy; Blancher, Antoine; Charron, Dominique; Cereb, Nezih; Maumy-Bertrand, Myriam; Bertrand, Frederic; Garrigue, Valerie; Pernin, Vincent; Weekers, Laurent; Naesens, Maarten; Kamar, Nassim; Legendre, Christophe; Glotz, Denis; Caillard, Sophie; Ladriere, Marc; Giral, Magali; Anglicheau, Dany; Bahram, Seiamak, and School of Medicine

Abstract

The identity of histocompatibility loci, besides human leukocyte antigen (HLA), remains elusive. The major histocompatibility complex (MHC) class I MICA gene is a candidate histocompatibility locus. Here, we investigate its role in a French multicenter cohort of 1,356 kidney transplants. MICA mismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45-3.11; P < 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) were strongly associated with increased antibody-mediated rejection (ABMR) (HR, 3.79; 95% CI: 1.94-7.39; P < 0.001; HR, 9.92; 95% CI: 7.43-13.20; P < 0.001, respectively). This effect was synergetic with that of anti-HLA DSA before and after transplantation (HR, 25.68; 95% CI: 3.31-199.41; P = 0.002; HR, 82.67; 95% CI: 33.67-202.97; P < 0.001, respectively). De novo-developed anti-MICA DSA were the most harmful because they were also associated with reduced graft survival (HR, 1.29; 95% CI: 1.05-1.58; P = 0.014). Finally, the damaging effect of anti-MICA DSA on graft survival was confirmed in an independent cohort of 168 patients with ABMR (HR, 1.71; 95% CI: 1.02-2.86; P = 0.041). In conclusion, assessment of MICA matching and immunization for the identification of patients at high risk for transplant rejection and loss is warranted., ‘Laboratoire d’Excellence’ (LabEx) TRANSPLANTEX; IdEx Unistra; SFRI-STRAT’US; INSERM; European Union (EU); European Regional Development Fund; INTERREG V Program; France’s National Research Agency (Agence Nationale de Recherche; ANR); Investment for the Future Program (Programme des Investissements d’Avenir; PIA); Strasbourg’s Interdisciplinary Thematic Institute (ITI) for Precision Medicine; TRANSPLANTEX NG; ITI 2021–2028 Program of the University of Strasbourg; CNRS; Institut Universitaire de France (IUF); Fédération Hospitalo-Universitaire (FHU) OMICARE; MSD Avenir ‘Autogen’

Published
2022

23. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

CDL HLA, CTI Spierings, Infection & Immunity, Cancer, Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M, Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, Bahram, Seiamak, CDL HLA, CTI Spierings, Infection & Immunity, Cancer, Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M, Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, and Bahram, Seiamak

Published
2022

27. The ahus registry results in Belgium

Author

Massart, Annick, Vande Walle, Johan, Snauwaert, Evelien, and Weekers, Laurent

Subjects
ahus, Medicine and Health Sciences, complement, TMA
Published
2022

30. Age-adapted percentiles of measured glomerular filtration in healthy individuals: extrapolation to living kidney donors over 65 years

Author

Delanaye, Pierre, primary, Gaillard, François, additional, van der Weijden, Jessica, additional, Mjøen, Geir, additional, Ferhman-Ekholm, Ingela, additional, Dubourg, Laurence, additional, Ebert, Natalie, additional, Schaeffner, Elke, additional, Åkerfeldt, Torbjörn, additional, Goffin, Karolien, additional, Couzi, Lionel, additional, Garrouste, Cyril, additional, Rostaing, Lionel, additional, Courbebaisse, Marie, additional, Legendre, Christophe, additional, Hourmant, Maryvonne, additional, Kamar, Nassim, additional, Cavalier, Etienne, additional, Weekers, Laurent, additional, Bouquegneau, Antoine, additional, de Borst, Martin H., additional, Mariat, Christophe, additional, Pottel, Hans, additional, and van Londen, Marco, additional

Published
2021
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31. The prospective screening for SARS-CoV-2 S1/S2 antibodies delineates the factual incidence of COVID-19 and shows a sustained serological response postCOVID-19 in kidney transplant recipients

Author

Firket, Louis, Bouquegneau, Antoine, Seidel, Laurence, Bonvoisin, Catherine, Grosch, Stéphanie, Hayette, Marie-Pierre, Jouret, François, and Weekers, Laurent

Abstract

ABSTRACTBackgroundThe impact of immunosuppression on the occurrence of Coronavirus Disease 2019 (COVID-19) remains unclear.MethodsWe conducted a prospective screening of anti-S1/S2 IgGs against SARS-CoV-2 Spike protein from March, 1 2020 to May, 15 2021 (prior to the vaccination campaign) in a cohort of 713 kidney transplant recipients (KTRs). In a first phase, the factual incidence and seroprevalence of COVID-19 was established in this cohort: cases diagnosed by serology were added to RT-PCR-based diagnoses to obtain the overall incidence of COVID-19 in both symptomatic and asymptomatic KTRs. In the second phase, the kinetics of the post-COVID-19 humoral response were studied, taking into account the severity of the disease defined by the need for oxygen therapy (group S, ”severe”) or not (group nS, ”not severe”).ResultsThe combined diagnostic approaches identified 138 COVID-19 cases (19.2%), with 37 diagnoses by serology (26.8%). The rate of asymptomatic KTRs reached 20.3% (28/138). Thirteen patients (9.4%) died from COVID-19. The seroconversion rate was 91.7% (99/108). The peak anti-S1/S2 IgG level was 85 [30-150] AU/ml and was similar between the S and nS groups (117 [38; 186] AU/ml versus73 [23; 140] AU/ml). A high probability of persistence of anti-S1/S2 IgG post-COVID-19 was observed, with only 10.1% (7/69) of the patients having negated their serology during the 9-month follow-up.ConclusionOur pragmatic serological screening combined with RT-PCR tests provides a better estimation of the real incidence of COVID-19 in KTRs. A significant proportion of KTRs develop humoral immunity postCOVID-19, which most often persists beyond 9 months.

Published
2023
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32. Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher (eGFR <45 mL/min)

Author

Bilo, Henk, Coentrão, Luis, Couchoud, Cécile, Covic, Adrian, De Sutter, Johan, Drechsler, Christiane, Gnudi, Luigi, Goldsmith, David, Heaf, James, Heimburger, Olof, Jager, Kitty J., Nacak, Hakan, Soler, Maria José, Van Huffel, Liesbeth, Tomson, Charlie, Van Laecke, Steven, Weekers, Laurent, Wieçek, Andrzej, Bolignano, Davide, Haller, Maria, Nagler, Evi, Nistor, Ionut, van der Veer, Sabine, and Van Biesen, Wim

Published
2015
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33. Dialysis modality choice in diabetic patients with end-stage kidney disease: a systematic review of the available evidence

Author

Couchoud, Cecile, Bolignano, Davide, Nistor, Ionut, Jager, Kitty J., Heaf, James, Heimburger, Olle, Van Biesen, Wim, Bilo, Henk, Bolignano, Davide, Coentrao, Louis, Couchoud, Cecile, Covic, Adrian, Drechsler, Christiane, De Sutter, Johan, Goldsmith, David, Gnudi, Luigi, Heaf, James, Heimburger, Olle, Jager, Kitty, Nacak, Hakan, Nistor, Ionut, Soler, Maria, Tomson, Charlie, Van Biesen, Wim, Vanhuffel, Liesbeth, Van Laecke, Steven, Weekers, Laurent, and Wiecek, Andrzej

Published
2015
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35. Recurrence and Outcome of Anti-Glomerular Basement Membrane Glomerulonephritis After Kidney Transplantation.

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Coche, Sophie, Sprangers, Ben, Van Laecke, Steven, Weekers, Laurent, De Meyer, Vicky, Hellemans, Rachel, Castanares Zapatero, Diego, Ameye, Heleen, Goffin, Eric, Demoulin, Nathalie, Gillion, Valentine, Mourad, Michel, Darius, Tom, Buemi, Antoine, Devresse, Arnaud, Kanaan, Nada, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Coche, Sophie, Sprangers, Ben, Van Laecke, Steven, Weekers, Laurent, De Meyer, Vicky, Hellemans, Rachel, Castanares Zapatero, Diego, Ameye, Heleen, Goffin, Eric, Demoulin, Nathalie, Gillion, Valentine, Mourad, Michel, Darius, Tom, Buemi, Antoine, Devresse, Arnaud, and Kanaan, Nada

Abstract

Recurrence of anti-glomerular basement membrane (anti-GBM) glomerulonephritis in the kidney graft is a rare event, described in limited reports. The aim of this study was to evaluate, in a large cohort of patients with long follow-up, the risk of recurrence of anti-GBM disease, the risk factors associated with clinical recurrence, and the long-term patient and graft survival. This was a multicenter retrospective study. Inclusion criteria were patients with anti-GBM glomerulonephritis who underwent transplantation of a kidney between 1977 and 2015. Exclusion criteria were systemic vasculitis, lupus erythematosus, and cryoglobulinemia. Recurrence was defined as reappearance of clinical signs of glomerulonephritis along with histological signs of proliferative glomerulonephritis and linear IgG staining on kidney biopsy, with or without anti-GBM antibodies. A total of 53 patients were included. Recurrence of anti-GBM glomerulonephritis in a first kidney transplant occurred in only 1 patient 5 years after transplantation (a prevalence rate of 1.9%) in the context of cessation of immunosuppressive drugs, and resulted in graft loss due to recurrence. Linear IgG staining on kidney biopsy in the absence of histological signs of proliferative glomerulonephritis was observed in 4 patients, in the context of cellular rejection. Patient survival was 100%, 94%, and 89% at 5, 10, and 15 years, respectively. Death-censored first-graft survival rates were 88%, 83%, and 79% at 5, 10, and 15 years, respectively. The recurrence rate of anti-GBM glomerulonephritis after transplantation is very low but is associated with graft loss. The long-term patient and graft survival rates are excellent.

Published
2021

36. Are there better alternatives than haemoglobin A1c to estimate glycaemic control in the chronic kidney disease population?

Author

Speeckaert, Marijn, Van Biesen, Wim, Delanghe, Joris, Slingerland, Robbert, Wiecek, Andrej, Heaf, James, Drechsler, Christiane, Lacatus, Raluca, Vanholder, Raymond, Nistor, Ionut, Bilo, Henk, Bolignano, Davide, Couchoud, Cecile, Covic, Adrian, Coentrao, Louis, Sutter, Johan De, Drechsler, Christiane, Gnudi, Luigi, Goldsmith, David, Heaf, James, Heimburger, Olle, Jager, Kitty, Nacak, Hakan, Nistor, Ionut, Soler, Maria, Tomson, Charlie, Vanhuffel, Liesbeth, Biesen, Wim Van, Laecke, Steven Van, Weekers, Laurent, and Wiecek, Andrzej

Published
2014
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39. FC 055PERCENTILES OF NORMAL MEASURED GLOMERULAR FILTRATION RATE BASED ON DATA FROM LIVING KIDNEY DONORS

Author

Gaillard, François, primary, Delanaye, Pierre, additional, Van Der Weijden, Jessica, additional, Mjøen, Geir, additional, Fehrman-Ekholm, Ingela, additional, Dubourg, Laurence, additional, Ebert, Natalie, additional, Schaeffner, Elke, additional, Akerfeldt, Torbjorn, additional, Goffin, Karolien, additional, Couzi, Lionel, additional, Garrouste, Cyril, additional, Rostaing, Lionel, additional, Courbebaisse, Marie, additional, Legendre, Christophe, additional, HOURMANT, Maryvonne, additional, Kamar, Nassim, additional, Weekers, Laurent, additional, Bouquegneau, Antoine, additional, De Borst, Martin, additional, Mariat, Christophe, additional, Pottel, Hans, additional, and Van Londen, Marco, additional

Published
2021
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40. MO939RECURRENCE AND OUTCOME OF ANTI-GLOMERULAR BASEMENT MEMBRANE GLOMERULONEPHRITIS AFTER KIDNEY TRANSPLANTATION: A BELGIAN MULTICENTER STUDY

Author

Coche, Sophie, primary, Sprangers, Ben, additional, Van Laecke, Steven, additional, Weekers, Laurent, additional, De Meyer, Vicky, additional, Hellemans, Rachel, additional, Castanares, Diego, additional, Ameye, Heleen, additional, Goffin, Eric Jean, additional, Demoulin, Nathalie, additional, Gillion, Valentine, additional, Mourad, Michel, additional, Darius, Tom, additional, Antoine, Buemi, additional, Arnaud, Devresse, additional, and Kanaan, Nada, additional

Published
2021
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42. Repeated kidney re-transplantation-the Eurotransplant experience: a retrospective multicenter outcome analysis

Author

Assfalg, Volker, Selig, Katharina, Tolksdorf, Johanna, van Meel, Marieke, de Vries, Erwin, Ramsoebhag, Anne-Marie, Rahmel, Axel, Renders, Lutz, Novotny, Alexander, Matevossian, Edouard, Schneeberger, Stefan, Rosenkranz, Alexander R., Berlakovich, Gabriela, Ysebaert, Dirk, Knops, Noel, Kuypers, Dirk, Weekers, Laurent, Muehlfeld, Anja, Rump, Lars-Christian, Hauser, Ingeborg, Pisarski, Przemyslaw, Weimer, Rolf, Fornara, Paolo, Fischer, Lutz, Kliem, Volker, Sester, Urban, Stippel, Dirk, Arns, Wolfgang, Hau, Hans-Michael, Nitschke, Martin, Hoyer, Joachim, Thorban, Stefan, Weinmann-Menke, Julia, Heller, Katharina, Banas, Bernhard, Schwenger, Vedat, Nadalin, Silvio, Lopau, Kai, Hueser, Norbert, Heemann, Uwe, Assfalg, Volker, Selig, Katharina, Tolksdorf, Johanna, van Meel, Marieke, de Vries, Erwin, Ramsoebhag, Anne-Marie, Rahmel, Axel, Renders, Lutz, Novotny, Alexander, Matevossian, Edouard, Schneeberger, Stefan, Rosenkranz, Alexander R., Berlakovich, Gabriela, Ysebaert, Dirk, Knops, Noel, Kuypers, Dirk, Weekers, Laurent, Muehlfeld, Anja, Rump, Lars-Christian, Hauser, Ingeborg, Pisarski, Przemyslaw, Weimer, Rolf, Fornara, Paolo, Fischer, Lutz, Kliem, Volker, Sester, Urban, Stippel, Dirk, Arns, Wolfgang, Hau, Hans-Michael, Nitschke, Martin, Hoyer, Joachim, Thorban, Stefan, Weinmann-Menke, Julia, Heller, Katharina, Banas, Bernhard, Schwenger, Vedat, Nadalin, Silvio, Lopau, Kai, Hueser, Norbert, and Heemann, Uwe

Abstract

In Eurotransplant kidney allocation system (ETKAS), candidates can be considered unlimitedly for repeated re-transplantation. Data on outcome and benefit are indeterminate. We performed a retrospective 15-year patient and graft outcome data analysis from 1464 recipients of a third or fourth or higher sequential deceased donor renal transplantation (DDRT) from 42 transplant centers. Repeated re-DDRT recipients were younger (mean 43.0 vs. 50.2 years) compared to first DDRT recipients. They received grafts with more favorable HLA matches (89.0% vs. 84.5%) but thereby no statistically significant improvement of patient and graft outcome was found as comparatively demonstrated in 1st DDRT. In the multivariate modeling accounting for confounding factors, mortality and graft loss after 3rd and >= 4th DDRT (P < 0.001 each) and death with functioning graft (DwFG) after 3rd DDRT (P = 0.001) were higher as compared to 1st DDRT. The incidence of primary nonfunction (PNF) was also significantly higher in re-DDRT (12.7%) than in 1st DDRT (7.1%; P < 0.001). Facing organ shortage, increasing waiting time, and considerable mortality on dialysis, we question the current policy of repeated re-DDRT. The data from this survey propose better HLA matching in first DDRT and second DDRT and careful selection of candidates, especially for >= 4th DDRT.

Published
2020

43. Antibiotics versus no therapy in kidney transplant recipients with asymptomatic bacteriuria (BiRT): a pragmatic, multicentre, randomized, controlled trial.

Author

Coussement, Julien, Kamar, Nassim, Matignon, Marie, Weekers, Laurent, Scemla, Anne, Giral, Magali, Racapé, Judith, Alamartine, Eric, Mesnard, Laurent, Kianda, Mireille N, Ghisdal, Lidia, Catalano, Concetta, Broeders, Emine Nilufer, Denis, Olivier, Wissing, Karl Martin, Hazzan, Marc, Abramowicz, Daniel, Bacteriuria in Renal Transplantation (BiRT) study group, Coussement, Julien, Kamar, Nassim, Matignon, Marie, Weekers, Laurent, Scemla, Anne, Giral, Magali, Racapé, Judith, Alamartine, Eric, Mesnard, Laurent, Kianda, Mireille N, Ghisdal, Lidia, Catalano, Concetta, Broeders, Emine Nilufer, Denis, Olivier, Wissing, Karl Martin, Hazzan, Marc, Abramowicz, Daniel, and Bacteriuria in Renal Transplantation (BiRT) study group

Abstract

Many transplant physicians screen for and treat asymptomatic bacteriuria (ASB) during post-kidney-transplant surveillance. We investigated whether antibiotics are effective in reducing the occurrence of symptomatic urinary tract infection (UTI) in kidney transplant recipients with ASB., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

44. Antibiotics versus no therapy in kidney transplant recipients with asymptomatic bacteriuria (BiRT): a pragmatic, multicentre, randomized, controlled trial

Author

Coussement, Julien, primary, Kamar, Nassim, additional, Matignon, Marie, additional, Weekers, Laurent, additional, Scemla, Anne, additional, Giral, Magali, additional, Racapé, Judith, additional, Alamartine, Éric, additional, Mesnard, Laurent, additional, Kianda, Mireille, additional, Ghisdal, Lidia, additional, Catalano, Concetta, additional, Broeders, Emine N., additional, Denis, Olivier, additional, Wissing, Karl M., additional, Hazzan, Marc, additional, Abramowicz, Daniel, additional, Beq, Audrey, additional, Besse-Hammer, Tatiana, additional, Blondel-Halley, Marie-Noëlle, additional, Borsu, Arnaud, additional, Charpy, Vianney, additional, Couzi, Lionel, additional, Debelle, Frédéric, additional, Bello, Arnaud del, additional, de Solere, Marie, additional, Frade, Sara, additional, Frimat, Luc, additional, Grimbert, Philippe, additional, Guerif, Pierrick, additional, Hellemans, Rachel, additional, Hodemon-Corne, Bénédicte, additional, Hougardy, Jean-Michel, additional, Le Moine, Alain, additional, Lietaer, Nicole, additional, Lortholary, Olivier, additional, Loudon, Kirsty, additional, Massart, Annick, additional, Meersman, Els, additional, Ouk, Thavarak, additional, Pipeleers, Lissa, additional, Roisin, Sandrine, additional, Tollot, Sarah, additional, Verhofstede, Sabine, additional, and Wojcik, Martin, additional

Published
2021
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49. BELGIAN EXPERIENCE OF DCD KIDNEY TRANSPLANTATION: O-157

Author

Darius, Tom, Jochmans, Ina, Ledinh, Hieu, Monbaliu, Diethard, Kuypers, Dirk, Mourad, Michel, De Pauw, Luc, Lerut, Jan, Detry, Olivier, Meurisse, Michel, Weekers, Laurent, Peeters, Patrick, Randon, Caren, Vandervennet, Marc, Bosmans, Jean-Louis, Roeyen, Geert, Ysebaert, Dirk, Abramovicz, Daniel, Mikhlaski, Dimitri, Sennesael, Jacques, Wissing, Martin, Rahmel, Axel, Squifflet, Jean-Paul, and Pirenne, Jacques

Published
2011

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