Search

Your search keyword '"Wee Joseph"' showing total 419 results
Start Over Author "Wee Joseph"
419 results on '"Wee Joseph"'

3. Analysis and design of randomised clinical trials involving competing risks endpoints

Author

Wee Joseph, Tai Bee-Choo, and Machin David

Subjects
Medicine (General), R5-920
Abstract

Abstract Background In randomised clinical trials involving time-to-event outcomes, the failures concerned may be events of an entirely different nature and as such define a classical competing risks framework. In designing and analysing clinical trials involving such endpoints, it is important to account for the competing events, and evaluate how each contributes to the overall failure. An appropriate choice of statistical model is important for adequate determination of sample size. Methods We describe how competing events may be summarised in such trials using cumulative incidence functions and Gray's test. The statistical modelling of competing events using proportional cause-specific and subdistribution hazard functions, and the corresponding procedures for sample size estimation are outlined. These are illustrated using data from a randomised clinical trial (SQNP01) of patients with advanced (non-metastatic) nasopharyngeal cancer. Results In this trial, treatment has no effect on the competing event of loco-regional recurrence. Thus the effects of treatment on the hazard of distant metastasis were similar via both the cause-specific (unadjusted csHR = 0.43, 95% CI 0.25 - 0.72) and subdistribution (unadjusted subHR 0.43; 95% CI 0.25 - 0.76) hazard analyses, in favour of concurrent chemo-radiotherapy followed by adjuvant chemotherapy. Adjusting for nodal status and tumour size did not alter the results. The results of the logrank test (p = 0.002) comparing the cause-specific hazards and the Gray's test (p = 0.003) comparing the cumulative incidences also led to the same conclusion. However, the subdistribution hazard analysis requires many more subjects than the cause-specific hazard analysis to detect the same magnitude of effect. Conclusions The cause-specific hazard analysis is appropriate for analysing competing risks outcomes when treatment has no effect on the cause-specific hazard of the competing event. It requires fewer subjects than the subdistribution hazard analysis for a similar effect size. However, if the main and competing events are influenced in opposing directions by an intervention, a subdistribution hazard analysis may be warranted.

Published
2011
Full Text
View/download PDF

4. Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data from randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01)

Author

Wee Joseph, Li Hui, Hwang Jacqueline, Loong Susan, Yap Swee, Chua Melvin, Fong Kam, and Tan Terence

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Over-expression of cyclooxygenase-2 (COX-2) enzyme has been reported in nasopharyngeal carcinoma (NPC). However, the prognostic significance of this has yet to be conclusively determined. Thus, from our randomized trial of radiation versus concurrent chemoradiation in endemic NPC, we analyzed a cohort of tumour samples collected from participants from one referral hospital. Methods 58 out of 88 patients from this institution had samples available for analysis. COX-2 expression levels were stratified by immunohistochemistry, into negligible, weak, moderate and strong, and correlated with overall and disease specific survivals. Results 58% had negligible or weak COX-2 expression, while 14% and 28% had moderate and strong expression respectively. Weak COX-2 expression conferred a poorer median overall survival, 1.3 years for weak versus 6.3 years for negligible, 7.8 years, strong and not reached for moderate. There was a similar trend for disease specific survival. Conclusion Contrary to literature published on other malignancies, our findings seemed to indicate that over-expression of COX-2 confer a better prognosis in patients with endemic NPC. Larger studies are required to conclusively determine the significance of COX-2 expression in these patients.

Published
2009
Full Text
View/download PDF

5. Order effects: a randomised study of three major cancer-specific quality of life instruments

Author

Thumboo Julian, Goh Cynthia, Lim Celestine, Cheung Yin-Bun, and Wee Joseph

Subjects
health-related quality of life, cancer, order effect, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background In methodological studies and outcomes research, questionnaires often comprise several health-related quality of life (HRQoL) measures. Previous psychological studies have suggested that changing the sequential order of measurement scales within a questionnaire could alter the pattern of responses. Yet, information on the presence or absence of order effects on the assessment of HRQoL in cancer patients is limited. Methods An incomplete block design was used in this study of 1277 cancer patients. Each patient filled out a questionnaire package that contained two of the three major cancer-specific HRQoL instruments, namely the Functional Assessment of Cancer Therapy – General, the European Organization for the Research and Treatment of Cancer Core Quality of Life Questionnaire and the Functional Living Index – Cancer. Within a questionnaire package the sequential order of the instruments contained were randomised. Measurement properties of the instruments, including the number of missing values, mean HRQoL scores, known-groups validity and internal consistency were compared between samples of different presentation orders. Results No effect of presentation order on the four properties aforementioned was found. Conclusion Presentation order is unlikely to alter the responses to these HRQoL instruments administered in cancer patients when any two of them are used together.

Published
2005
Full Text
View/download PDF

6. Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis

Author

Aupérin, Anne, Blanchard, Pierre, Benhamou, Ellen, Bourhis, Jean, Carmel, Alexandra, Chakrabandhu, Somvilai, Chan, Anthony TC, Chen, Lei, Chen, Ming-Yuan, Chen, Qiu-Yan, Chen, Yong, Chappell, Richard J, Choi, Horace, Chua, Daniel TT, Chua, Melvien Lee Kiang, Fountzilas, George, Higgins, Julian, Hong, Ming Huang, Hong, Ruey-Long, Huang, Pei-Yu, Hui, Edwin Pun, Hsiao, Chin-Fu, Kam, Michael, Koliou, Georgia Angeliki, Kwong, Dora L W, Lacas, Benjamin, Lai, Shu-Chuan, Lam, Ka On, LeBlanc, Michael L, Lee, Anne WM, Lee, Ho Fun Victor, Li, Wen Fei, Lim, Yoke, Ma, Brigette, Ma, Jun, Mai, Hai-Qiang, Mo, Frankie, Moon, James, Ng, Wai Tong, Ngan, Roger, Ollivier, Camille, O'Sullivan, Brian, Petit, Claire, Pignon, Jean-Pierre, Poh, Sharon X, Rücker, Gerta, Sham, Jonathan, Soong, Yoke Lim, Sun, Ying, Tan, Terence, Tang, Lin-Quan, Tung, Yuk, Wee, Joseph, Wu, Xuang, Xu, Tingting, Zhang, Li, Zhang, Yuan, Zhu, Guopei, Lee, Anne, Chan, Anthony T C, Li, Wen-Fei, Ngan, Roger K C, Hui, Edwin P, and Auperin, Anne

Published
2023
Full Text
View/download PDF

8. International recommendations for plasma Epstein-Barr virus DNA measurement in nasopharyngeal carcinoma in resource-constrained settings: lessons from the COVID-19 pandemic

Author

Lee, Victor Ho-Fun, Adham, Marlinda, Ben Kridis, Wala, Bossi, Paolo, Chen, Ming-Yuan, Chitapanarux, Imjai, Gregoire, Vincent, Hao, Sheng Po, Ho, Cheryl, Ho, Gwo Fuang, Kannarunimit, Danita, Kwong, Dora Lai-Wan, Lam, Ka-On, Lam, Wai Kei Jacky, Le, Quynh-Thu, Lee, Anne Wing-Mui, Lee, Nancy Y, Leung, To-Wai, Licitra, Lisa, Lim, Darren Wan-Teck, Lin, Jin-Ching, Loh, Kwok Seng, Lou, Pei-Jen, Machiels, Jean-Pascal, Mai, Hai-Qiang, Mesía, Ricard, Ng, Wai-Tong, Ngan, Roger Kai-Cheong, Tay, Joshua K, Tsang, Raymond King-Yin, Tong, Chi-Chung, Wang, Hung-Ming, and Wee, Joseph T

Published
2022
Full Text
View/download PDF

9. Self‐Degrading Molecular Organogels: Self‐Assembled Gels Programmed to Spontaneously Liquefy after a Set Time.

Author

Burni, Faraz A., Xu, Wenhao, Spencer, Reuben G., Bergstrom, Evan, Chappell, David, Wee, Joseph K., and Raghavan, Srinivasa R.

Subjects
SMALL molecules, FLUID flow, HYDROCHLORIC acid, ORGANIC solvents, SORBITOL
Abstract

Gels are used in the oilfield. For example, during oil recovery, organogels are pumped underground into fractures within oil‐bearing rock, so as to block fluid flow. However, after several days, the gels must be degraded (liquefied) to enable oil extraction through the fractures. To degrade gels, 'degrading agents' as well as external stimuli have been examined. Here, a concept is demonstrated that avoids external agents and stimuli: self‐degrading organogels based on the self‐assembly of molecular gelators. The gels are a) extremely robust (free standing solids) at time t = 0 and (b) degrade spontaneously into a sol after a set time t = tdegr that can be minutes, hours, or days. These properties are achieved by combining two readily available molecules — the organogelator (1,3:2,4)‐dibenzylidene sorbitol (DBS) and an acid (e.g., hydrochloric acid, HCl) — in an organic solvent. DBS self‐assembles into nanoscale fibrils, which connect into a 3‐D network, thereby gelling the solvent. The acid type and concentration set the value of tdegr at a given temperature. Degradation occurs because the acid slowly hydrolyzes the acetals on DBS, thereby converting DBS into small molecules that cannot form fibrils. DBS gels with a pre‐programmed "degradation clock" can be made with both polar and non‐polar organic solvents. The concept can be a game‐changer for oil recovery as it promises to make it safer, more efficient, and sustainable. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Meta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients

Author

Aupérin, Anne, Blanchard, Pierre, Benhamou, Ellen, Bourhis, Jean, Carmel, Alexandra, Chakrabandhu, Somvilai, TC Chan, Anthony, Chen, Lei, Chen, Ming-Yuan, Chen, Qiu-Yan, Chen, Yong, Chappell, Richard J, Choi, Horace, TT Chua, Daniel, Lee Kiang Chua, Melvin, Fountzilas, George, Higgins, Julian, Hong, Ming-Huang, Hong, Ruey-Long, Huang, Pei-Yu, Pun Hui, Edwin, Hsiao, C.F., Kam, Michael, Angeliki Koliou, Georgia, LW Kwong, Dora, Lacas, Benjamin, Lai, Shu-Chuan, On Lam, Ka, LeBlanc, Michael L, WM Lee, Anne, Fun Victor Lee, Ho, Fei Li, Wen, Ma, Brigette, Ma, Jun, Mai, Hai-Qiang, Mo, Frankie, Moon, James, Tong Ng, Wai, Ngan, Roger, Ollivier, Camille, O'Sullivan, Brian, Petit, Claire, Pierre Pignon, Jean, Poh, Sharon X., Rücker, Gerta, Sham, Jonathan, Lim Soong, Yoke, Sun, Ying, Tan, Terence, Tang, Lin-Quan, Tung, Yuk, Wee, Joseph, Wu, Xuang, Xu, Tingting, Zhang, Li, Zhang, Yuan, Zhu, Guopei, Lee, Anne W.M., Wai Tong, Ng, Chan, Anthony T.C., Hong, Ruey Long, Li, Wen-Fei, Kwong, Dora L.W., Poh, Sharon S.X., and Pignon, Jean-Pierre

Published
2022
Full Text
View/download PDF

11. International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma

Author

Ng, Wai Tong, Soong, Yoke Lim, Ahn, Yong Chan, AlHussain, Hussain, Choi, Horace C.W., Corry, June, Grégoire, Vincent, Harrington, Kevin J., Hu, Chao Su, Jensen, Kenneth, Kwong, Dora L., Langendijk, Johannes A., Le, Quynh Thu, Lee, Nancy Y., Lin, Jin Ching, Lu, Tai Xiang, Mendenhall, William M., O’Sullivan, Brian, Ozyar, Enis, Pan, Jian Ji, Peters, Lester J., Poh, Sharon S., Rosenthal, David I., Sanguineti, Giuseppe, Tao, Yungan, Wee, Joseph T., Yom, Sue S., Chua, Melvin L.K., and Lee, Anne W.M.

Published
2021
Full Text
View/download PDF

13. High-Dimensional Characterization of the Systemic Immune Landscape Informs on Synergism Between Radiation Therapy and Immune Checkpoint Blockade

Author

Chua, Kevin L.M., Fehlings, Michael, Yeo, Eugenia L.L., Nardin, Alessandra, Sumatoh, Hermi, Chu, Pek Lim, Nei, Wen-long, Ong, Enya H.W., Woo, Wai Yee, Low, Kar Perng, Wang, Haitao, Poon, Dennis J.J., Liang, Zhong-guo, Yao, Kai, Huang, Luo, Toh, Chee Keong, Ang, Mei-Kim, Farid, Mohamad, Cheng, Xin Min, Kanesvaran, Ravindran, Dent, Rebecca, Wee, Joseph T.S., Lim, Tony K.H., Iyer, N. Gopalakrishna, Tan, Daniel S.W., Soo, Khee Chee, Newell, Evan W., and Chua, Melvin L.K.

Published
2020
Full Text
View/download PDF

15. Genomic analyses inform on migration events during the peopling of Eurasia

Author

Pagani, Luca, Lawson, Daniel John, Jagoda, Evelyn, Mörseburg, Alexander, Eriksson, Anders, Mitt, Mario, Clemente, Florian, Hudjashov, Georgi, DeGiorgio, Michael, Saag, Lauri, Wall, Jeffrey D, Cardona, Alexia, Mägi, Reedik, Sayres, Melissa A Wilson, Kaewert, Sarah, Inchley, Charlotte, Scheib, Christiana L, Järve, Mari, Karmin, Monika, Jacobs, Guy S, Antao, Tiago, Iliescu, Florin Mircea, Kushniarevich, Alena, Ayub, Qasim, Tyler-Smith, Chris, Xue, Yali, Yunusbayev, Bayazit, Tambets, Kristiina, Mallick, Chandana Basu, Saag, Lehti, Pocheshkhova, Elvira, Andriadze, George, Muller, Craig, Westaway, Michael C, Lambert, David M, Zoraqi, Grigor, Turdikulova, Shahlo, Dalimova, Dilbar, Sabitov, Zhaxylyk, Sultana, Gazi Nurun Nahar, Lachance, Joseph, Tishkoff, Sarah, Momynaliev, Kuvat, Isakova, Jainagul, Damba, Larisa D, Gubina, Marina, Nymadawa, Pagbajabyn, Evseeva, Irina, Atramentova, Lubov, Utevska, Olga, Ricaut, François-Xavier, Brucato, Nicolas, Sudoyo, Herawati, Letellier, Thierry, Cox, Murray P, Barashkov, Nikolay A, Škaro, Vedrana, Mulahasanovic´, Lejla, Primorac, Dragan, Sahakyan, Hovhannes, Mormina, Maru, Eichstaedt, Christina A, Lichman, Daria V, Abdullah, Syafiq, Chaubey, Gyaneshwer, Wee, Joseph TS, Mihailov, Evelin, Karunas, Alexandra, Litvinov, Sergei, Khusainova, Rita, Ekomasova, Natalya, Akhmetova, Vita, Khidiyatova, Irina, Marjanović, Damir, Yepiskoposyan, Levon, Behar, Doron M, Balanovska, Elena, Metspalu, Andres, Derenko, Miroslava, Malyarchuk, Boris, Voevoda, Mikhail, Fedorova, Sardana A, Osipova, Ludmila P, Lahr, Marta Mirazón, Gerbault, Pascale, Leavesley, Matthew, Migliano, Andrea Bamberg, Petraglia, Michael, Balanovsky, Oleg, Khusnutdinova, Elza K, Metspalu, Ene, Thomas, Mark G, Manica, Andrea, Nielsen, Rasmus, Villems, Richard, Willerslev, Eske, Kivisild, Toomas, and Metspalu, Mait

Subjects
Human Genome, Biotechnology, Genetics, Generic health relevance, Africa, Animals, Asia, Datasets as Topic, Estonia, Europe, Fossils, Gene Flow, Genetics, Population, Genome, Human, Genomics, Heterozygote, History, Ancient, Human Migration, Humans, Native Hawaiian or Other Pacific Islander, Neanderthals, New Guinea, Population Dynamics, Racial Groups, General Science & Technology
Abstract

High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history and refuelled the debate on the mutation rate in humans. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record, and admixture between AMHs and Neanderthals predating the main Eurasian expansion, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago.

Published
2016

16. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

Author

Mallick, Swapan, Li, Heng, Lipson, Mark, Mathieson, Iain, Gymrek, Melissa, Racimo, Fernando, Zhao, Mengyao, Chennagiri, Niru, Nordenfelt, Susanne, Tandon, Arti, Skoglund, Pontus, Lazaridis, Iosif, Sankararaman, Sriram, Fu, Qiaomei, Rohland, Nadin, Renaud, Gabriel, Erlich, Yaniv, Willems, Thomas, Gallo, Carla, Spence, Jeffrey P, Song, Yun S, Poletti, Giovanni, Balloux, Francois, van Driem, George, de Knijff, Peter, Romero, Irene Gallego, Jha, Aashish R, Behar, Doron M, Bravi, Claudio M, Capelli, Cristian, Hervig, Tor, Moreno-Estrada, Andres, Posukh, Olga L, Balanovska, Elena, Balanovsky, Oleg, Karachanak-Yankova, Sena, Sahakyan, Hovhannes, Toncheva, Draga, Yepiskoposyan, Levon, Tyler-Smith, Chris, Xue, Yali, Abdullah, M Syafiq, Ruiz-Linares, Andres, Beall, Cynthia M, Di Rienzo, Anna, Jeong, Choongwon, Starikovskaya, Elena B, Metspalu, Ene, Parik, Jüri, Villems, Richard, Henn, Brenna M, Hodoglugil, Ugur, Mahley, Robert, Sajantila, Antti, Stamatoyannopoulos, George, Wee, Joseph TS, Khusainova, Rita, Khusnutdinova, Elza, Litvinov, Sergey, Ayodo, George, Comas, David, Hammer, Michael F, Kivisild, Toomas, Klitz, William, Winkler, Cheryl A, Labuda, Damian, Bamshad, Michael, Jorde, Lynn B, Tishkoff, Sarah A, Watkins, W Scott, Metspalu, Mait, Dryomov, Stanislav, Sukernik, Rem, Singh, Lalji, Thangaraj, Kumarasamy, Pääbo, Svante, Kelso, Janet, Patterson, Nick, and Reich, David

Subjects
Human Genome, Genetics, Animals, Australia, Black People, Datasets as Topic, Genetic Variation, Genetics, Population, Genome, Human, Genomics, History, Ancient, Human Migration, Humans, Mutation Rate, Native Hawaiian or Other Pacific Islander, Neanderthals, New Guinea, Phylogeny, Racial Groups, Sequence Analysis, DNA, Species Specificity, Time Factors, General Science & Technology
Abstract

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.

Published
2016

17. Global diversity, population stratification, and selection of human copy-number variation.

Author

Krumm, Niklas, Huddleston, John, Coe, Bradley, Baker, Carl, Nordenfelt, Susanne, Bamshad, Michael, Jorde, Lynn, Posukh, Olga, Sahakyan, Hovhannes, Watkins, W, Yepiskoposyan, Levon, Abdullah, M, Bravi, Claudio, Capelli, Cristian, Hervig, Tor, Wee, Joseph, Tyler-Smith, Chris, van Driem, George, Romero, Irene, Jha, Aashish, Karachanak-Yankova, Sena, Toncheva, Draga, Comas, David, Kivisild, Toomas, Ruiz-Linares, Andres, Sajantila, Antti, Metspalu, Ene, Parik, Jüri, Villems, Richard, Starikovskaya, Elena, Ayodo, George, Beall, Cynthia, Di Rienzo, Anna, Hammer, Michael, Khusainova, Rita, Khusnutdinova, Elza, Klitz, William, Winkler, Cheryl, Labuda, Damian, Metspalu, Mait, Tishkoff, Sarah, Dryomov, Stanislav, Sukernik, Rem, Patterson, Nick, Reich, David, Eichler, Evan, Mallick, Swapan, Nelson, Bradley, Hormozdiari, Fereydoun, Henn, Brenna, and Sudmant, Peter

Subjects
Animals, Black People, DNA Copy Number Variations, Evolution, Molecular, Gene Duplication, Genome, Human, Hominidae, Humans, Native Hawaiian or Other Pacific Islander, Phylogeny, Polymorphism, Single Nucleotide, Population, Selection, Genetic, Sequence Deletion
Abstract

In order to explore the diversity and selective signatures of duplication and deletion human copy-number variants (CNVs), we sequenced 236 individuals from 125 distinct human populations. We observed that duplications exhibit fundamentally different population genetic and selective signatures than deletions and are more likely to be stratified between human populations. Through reconstruction of the ancestral human genome, we identify megabases of DNA lost in different human lineages and pinpoint large duplications that introgressed from the extinct Denisova lineage now found at high frequency exclusively in Oceanic populations. We find that the proportion of CNV base pairs to single-nucleotide-variant base pairs is greater among non-Africans than it is among African populations, but we conclude that this difference is likely due to unique aspects of non-African population history as opposed to differences in CNV load.

Published
2015

18. Global diversity, population stratification, and selection of human copy-number variation

Author

Sudmant, Peter H, Mallick, Swapan, Nelson, Bradley J, Hormozdiari, Fereydoun, Krumm, Niklas, Huddleston, John, Coe, Bradley P, Baker, Carl, Nordenfelt, Susanne, Bamshad, Michael, Jorde, Lynn B, Posukh, Olga L, Sahakyan, Hovhannes, Watkins, W Scott, Yepiskoposyan, Levon, Abdullah, M Syafiq, Bravi, Claudio M, Capelli, Cristian, Hervig, Tor, Wee, Joseph TS, Tyler-Smith, Chris, van Driem, George, Romero, Irene Gallego, Jha, Aashish R, Karachanak-Yankova, Sena, Toncheva, Draga, Comas, David, Henn, Brenna, Kivisild, Toomas, Ruiz-Linares, Andres, Sajantila, Antti, Metspalu, Ene, Parik, Jüri, Villems, Richard, Starikovskaya, Elena B, Ayodo, George, Beall, Cynthia M, Di Rienzo, Anna, Hammer, Michael F, Khusainova, Rita, Khusnutdinova, Elza, Klitz, William, Winkler, Cheryl, Labuda, Damian, Metspalu, Mait, Tishkoff, Sarah A, Dryomov, Stanislav, Sukernik, Rem, Patterson, Nick, Reich, David, and Eichler, Evan E

Subjects
Genetics, Human Genome, Animals, Black People, DNA Copy Number Variations, Evolution, Molecular, Gene Duplication, Genome, Human, Hominidae, Humans, Native Hawaiian or Other Pacific Islander, Phylogeny, Polymorphism, Single Nucleotide, Population, Selection, Genetic, Sequence Deletion, General Science & Technology
Abstract

In order to explore the diversity and selective signatures of duplication and deletion human copy-number variants (CNVs), we sequenced 236 individuals from 125 distinct human populations. We observed that duplications exhibit fundamentally different population genetic and selective signatures than deletions and are more likely to be stratified between human populations. Through reconstruction of the ancestral human genome, we identify megabases of DNA lost in different human lineages and pinpoint large duplications that introgressed from the extinct Denisova lineage now found at high frequency exclusively in Oceanic populations. We find that the proportion of CNV base pairs to single-nucleotide-variant base pairs is greater among non-Africans than it is among African populations, but we conclude that this difference is likely due to unique aspects of non-African population history as opposed to differences in CNV load.

Published
2015

19. International Guideline on Dose Prioritization and Acceptance Criteria in Radiation Therapy Planning for Nasopharyngeal Carcinoma

Author

Lee, Anne W., Ng, Wai Tong, Pan, Jian Ji, Chiang, Chi-Leung, Poh, Sharon S., Choi, Horace C., Ahn, Yong Chan, AlHussain, Hussain, Corry, June, Grau, Cai, Grégoire, Vincent, Harrington, Kevin J., Hu, Chao Su, Kwong, Dora L., Langendijk, Johannes A., Le, Quynh Thu, Lee, Nancy Y., Lin, Jin Ching, Lu, Tai Xiang, Mendenhall, William M., O'Sullivan, Brian, Ozyar, Enis, Peters, Lester J., Rosenthal, David I., Sanguineti, Giuseppe, Soong, Yoke Lim, Tao, Yungan, Yom, Sue S., and Wee, Joseph T.

Published
2019
Full Text
View/download PDF

24. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines

Author

Grégoire, Vincent, Evans, Mererid, Le, Quynh-Thu, Bourhis, Jean, Budach, Volker, Chen, Amy, Eisbruch, Abraham, Feng, Mei, Giralt, Jordi, Gupta, Tejpal, Hamoir, Marc, Helito, Juliana K., Hu, Chaosu, Hunter, Keith, Johansen, Jorgen, Kaanders, Johannes, Laskar, Sarbani Ghosh, Lee, Anne, Maingon, Philippe, Mäkitie, Antti, Micciche', Francesco, Nicolai, Piero, O'Sullivan, Brian, Poitevin, Adela, Porceddu, Sandro, Składowski, Krzysztof, Tribius, Silke, Waldron, John, Wee, Joseph, Yao, Min, Yom, Sue S., Zimmermann, Frank, and Grau, Cai

Published
2018
Full Text
View/download PDF

25. International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma

Author

Lee, Anne W., Ng, Wai Tong, Pan, Jian Ji, Poh, Sharon S., Ahn, Yong Chan, AlHussain, Hussain, Corry, June, Grau, Cai, Grégoire, Vincent, Harrington, Kevin J., Hu, Chao Su, Kwong, Dora L., Langendijk, Johannes A., Le, Quynh Thu, Lee, Nancy Y., Lin, Jin Ching, Lu, Tai Xiang, Mendenhall, William M., O'Sullivan, Brian, Ozyar, Enis, Peters, Lester J., Rosenthal, David I., Soong, Yoke Lim, Tao, Yungan, Yom, Sue S., and Wee, Joseph T.

Published
2018
Full Text
View/download PDF

26. The Americanization of a Filipina U.S. Navy Wife

Author

Wee, Joseph Ryan

Subjects
Filipina, Glass ceiling, Navy, Wife, immigrant, Asian American Studies, Ethnic Studies
Abstract

This story places a biography in the context of history. It describes the life of a Filipina immigrant to the United States during the Civil Rights movement and the Cold War in the context of U.S.-Philippine international relations and the boom of the aerospace industry.

Published
2012

28. Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis

Author

Petit, Claire, primary, Lee, Anne, additional, Ma, Jun, additional, Lacas, Benjamin, additional, Ng, Wai Tong, additional, Chan, Anthony T C, additional, Hong, Ruey-Long, additional, Chen, Ming-Yuan, additional, Chen, Lei, additional, Li, Wen-Fei, additional, Huang, Pei-Yu, additional, Tan, Terence, additional, Ngan, Roger K C, additional, Zhu, Guopei, additional, Mai, Hai-Qiang, additional, Hui, Edwin P, additional, Fountzilas, George, additional, Zhang, Li, additional, Carmel, Alexandra, additional, Kwong, Dora L W, additional, Moon, James, additional, Bourhis, Jean, additional, Auperin, Anne, additional, Pignon, Jean-Pierre, additional, Blanchard, Pierre, additional, Aupérin, Anne, additional, Benhamou, Ellen, additional, Chakrabandhu, Somvilai, additional, Chan, Anthony TC, additional, Chen, Qiu-Yan, additional, Chen, Yong, additional, Chappell, Richard J, additional, Choi, Horace, additional, Chua, Daniel TT, additional, Chua, Melvien Lee Kiang, additional, Higgins, Julian, additional, Hong, Ming Huang, additional, Hui, Edwin Pun, additional, Hsiao, Chin-Fu, additional, Kam, Michael, additional, Koliou, Georgia Angeliki, additional, Lai, Shu-Chuan, additional, Lam, Ka On, additional, LeBlanc, Michael L, additional, Lee, Anne WM, additional, Lee, Ho Fun Victor, additional, Li, Wen Fei, additional, Lim, Yoke, additional, Ma, Brigette, additional, Mo, Frankie, additional, Ngan, Roger, additional, Ollivier, Camille, additional, O'Sullivan, Brian, additional, Petit, Claire, additional, Poh, Sharon X, additional, Rücker, Gerta, additional, Sham, Jonathan, additional, Soong, Yoke Lim, additional, Sun, Ying, additional, Tang, Lin-Quan, additional, Tung, Yuk, additional, Wee, Joseph, additional, Wu, Xuang, additional, Xu, Tingting, additional, and Zhang, Yuan, additional

Published
2023
Full Text
View/download PDF

31. 18F‐FMISO PET‐guided dose escalation with multifield optimization intensity‐modulated proton therapy in nasopharyngeal carcinoma

Author

Sommat, Kiattisa, primary, Tong, Aaron Kian Ti, additional, Ong, Ashley Li Kuan, additional, Hu, Jing, additional, Sin, Sze Yarn, additional, Lam, Winnie Wing Chuen, additional, Xie, Wanying, additional, Khor, Yiu Ming, additional, Lim, Cindy, additional, Lim, Tze Wei, additional, Selvarajan, Sathiyamoorthy, additional, Wang, Fuqiang, additional, Tan, Terence Wee Kiat, additional, Wee, Joseph Tien Seng, additional, Soong, Yoke Lim, additional, Fong, Kam Weng, additional, Hennedige, Tiffany, additional, and Hua, Thng Choon, additional

Published
2023
Full Text
View/download PDF

32. Supplementary Materials from Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials

Author

Chen, Yu-Pei, primary, Tang, Ling-Long, primary, Yang, Qi, primary, Poh, Sharon-Shuxian, primary, Hui, Edwin P., primary, Chan, Anthony T.C., primary, Ong, Whee-Sze, primary, Tan, Terence, primary, Wee, Joseph, primary, Li, Wen-Fei, primary, Chen, Lei, primary, Ma, Brigette B.Y., primary, Tong, Macy, primary, Tan, Sze-Huey, primary, Cheah, Shie-Lee, primary, Fong, Kam-Weng, primary, Sommat, Kiattisa, primary, Soong, Yoke Lim, primary, Guo, Ying, primary, Lin, Ai-Hua, primary, Sun, Ying, primary, Hong, Ming-Huang, primary, Cao, Su-Mei, primary, Chen, Ming-Yuan, primary, and Ma, Jun, primary

Published
2023
Full Text
View/download PDF

39. Intra-patient and inter-patient comparisons of DNA damage response biomarkers in Nasopharynx Cancer (NPC): analysis of NCC0901 randomised controlled trial of induction chemotherapy in locally advanced NPC

Author

Chua, Kevin Lee Min, Yeo, Eugenia Li Ling, Shihabudeen, Waseem Ahamed, Tan, Sze Huey, Shwe, Than Than, Ong, Enya Hui Wen, Lam, Paula Yeng Po, Soo, Khee Chee, Soong, Yoke Lim, Fong, Kam Weng, Tan, Terence Wee Kiat, Wee, Joseph Tien Seng, and Chua, Melvin Lee Kiang

Published
2018
Full Text
View/download PDF

43. Meta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients

Author

Blanchard, Pierre, primary, Lee, Anne W.M., additional, Carmel, Alexandra, additional, Wai Tong, Ng, additional, Ma, Jun, additional, Chan, Anthony T.C., additional, Hong, Ruey Long, additional, Chen, Ming-Yuan, additional, Chen, Lei, additional, Li, Wen-Fei, additional, Huang, Pei-Yu, additional, Kwong, Dora L.W., additional, Poh, Sharon S.X., additional, Ngan, Roger, additional, Mai, Hai-Qiang, additional, Ollivier, Camille, additional, Fountzilas, George, additional, Zhang, Li, additional, Bourhis, Jean, additional, Aupérin, Anne, additional, Lacas, Benjamin, additional, Pignon, Jean-Pierre, additional, Blanchard, Pierre, additional, Benhamou, Ellen, additional, Chakrabandhu, Somvilai, additional, TC Chan, Anthony, additional, Chen, Qiu-Yan, additional, Chen, Yong, additional, Chappell, Richard J, additional, Choi, Horace, additional, TT Chua, Daniel, additional, Lee Kiang Chua, Melvin, additional, Higgins, Julian, additional, Hong, Ming-Huang, additional, Hong, Ruey-Long, additional, Pun Hui, Edwin, additional, Hsiao, C.F., additional, Kam, Michael, additional, Angeliki Koliou, Georgia, additional, LW Kwong, Dora, additional, Lai, Shu-Chuan, additional, On Lam, Ka, additional, LeBlanc, Michael L, additional, WM Lee, Anne, additional, Fun Victor Lee, Ho, additional, Fei Li, Wen, additional, Ma, Brigette, additional, Mo, Frankie, additional, Moon, James, additional, Tong Ng, Wai, additional, O'Sullivan, Brian, additional, Petit, Claire, additional, Pierre Pignon, Jean, additional, Poh, Sharon X., additional, Rücker, Gerta, additional, Sham, Jonathan, additional, Lim Soong, Yoke, additional, Sun, Ying, additional, Tan, Terence, additional, Tang, Lin-Quan, additional, Tung, Yuk, additional, Wee, Joseph, additional, Wu, Xuang, additional, Xu, Tingting, additional, Zhang, Yuan, additional, and Zhu, Guopei, additional

Published
2022
Full Text
View/download PDF

46. HUMAN GENOMICS: Global diversity, population stratification, and selection of human copy-number variation

Author

Sudmant, Peter H., Mallick, Swapan, Nelson, Bradley J., Hormozdiari, Fereydoun, Krumm, Niklas, Huddleston, John, Coe, Bradley P., Baker, Carl, Nordenfelt, Susanne, Bamshad, Michael, Jorde, Lynn B., Posukh, Olga L., Sahakyan, Hovhannes, Watkins, Scott W., Yepiskoposyan, Levon, Abdullah, Syafiq M., Bravi, Claudio M., Capelli, Cristian, Hervig, Tor, Wee, Joseph T. S., Tyler-Smith, Chris, van Driem, George, Romero, Irene Gallego, Jha, Aashish R., Karachanak-Yankova, Sena, Toncheva, Draga, Comas, David, Henn, Brenna, Kivisild, Toomas, Ruiz-Linares, Andres, Sajantila, Antti, Metspalu, Ene, Parik, Jüri, Villems, Richard, Starikovskaya, Elena B., Ayodo, George, Beall, Cynthia M., Di Rienzo, Anna, Hammer, Michael F., Khusainova, Rita, Khusnutdinova, Elza, Klitz, William, Winkler, Cheryl, Labuda, Damian, Metspalu, Mait, Tishkoff, Sarah A., Dryomov, Stanislav, Sukernik, Rem, Patterson, Nick, Reich, David, and Eichler, Evan E.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results