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4. Meta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients

Author

Aupérin, Anne, Blanchard, Pierre, Benhamou, Ellen, Bourhis, Jean, Carmel, Alexandra, Chakrabandhu, Somvilai, TC Chan, Anthony, Chen, Lei, Chen, Ming-Yuan, Chen, Qiu-Yan, Chen, Yong, Chappell, Richard J, Choi, Horace, TT Chua, Daniel, Lee Kiang Chua, Melvin, Fountzilas, George, Higgins, Julian, Hong, Ming-Huang, Hong, Ruey-Long, Huang, Pei-Yu, Pun Hui, Edwin, Hsiao, C.F., Kam, Michael, Angeliki Koliou, Georgia, LW Kwong, Dora, Lacas, Benjamin, Lai, Shu-Chuan, On Lam, Ka, LeBlanc, Michael L, WM Lee, Anne, Fun Victor Lee, Ho, Fei Li, Wen, Ma, Brigette, Ma, Jun, Mai, Hai-Qiang, Mo, Frankie, Moon, James, Tong Ng, Wai, Ngan, Roger, Ollivier, Camille, O'Sullivan, Brian, Petit, Claire, Pierre Pignon, Jean, Poh, Sharon X., Rücker, Gerta, Sham, Jonathan, Lim Soong, Yoke, Sun, Ying, Tan, Terence, Tang, Lin-Quan, Tung, Yuk, Wee, Joseph, Wu, Xuang, Xu, Tingting, Zhang, Li, Zhang, Yuan, Zhu, Guopei, Lee, Anne W.M., Wai Tong, Ng, Chan, Anthony T.C., Hong, Ruey Long, Li, Wen-Fei, Kwong, Dora L.W., Poh, Sharon S.X., and Pignon, Jean-Pierre

Published
2022
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7. Monocytic Myeloid-Derived Suppressor Cells Underpin Resistance to Adoptive T Cell Therapy in Nasopharyngeal Carcinoma

Author

Hopkins, Richard, Xiang, Wenwei, Marlier, Damien, Au, Veonice Bijin, Ching, Qianting, Wu, Lynn Xue, Guan, Rujun, Lee, Bernett, Chia, Whay-Kuang, Wang, Who-Whong, Wee, Joseph, Ng, Joanna, Cheong, Rachael, Han, Shuting, Chu, Axel, Chee, Chit Lai, Shuen, Timothy, Podinger, Michael, Lezhava, Alexander, Toh, Han Chong, and Connolly, John E.

Published
2021
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8. 18F‐FMISO PET‐guided dose escalation with multifield optimization intensity‐modulated proton therapy in nasopharyngeal carcinoma.

Author

Sommat, Kiattisa, Tong, Aaron Kian Ti, Ong, Ashley Li Kuan, Hu, Jing, Sin, Sze Yarn, Lam, Winnie Wing Chuen, Xie, Wanying, Khor, Yiu Ming, Lim, Cindy, Lim, Tze Wei, Selvarajan, Sathiyamoorthy, Wang, Fuqiang, Tan, Terence Wee Kiat, Wee, Joseph Tien Seng, Soong, Yoke Lim, Fong, Kam Weng, Hennedige, Tiffany, and Hua, Thng Choon

Subjects
POSITRON emission tomography computed tomography, PROTON therapy, MUSCLE tumors, COMPUTED tomography, NASOPHARYNX cancer, RADIOTHERAPY, VOLUMETRIC-modulated arc therapy
Abstract

Purpose: The purpose of this study was to evaluate the radiotherapy planning feasibility of dose escalation with intensity‐modulated proton therapy (IMPT) to hypoxic tumor regions identified on 18F‐Fluoromisonidazole (FMISO) positron emission tomography and computed tomography (PET‐CT) in NPC. Materials and methods: Nine patients with stages T3‐4N0‐3M0 NPC underwent 18F‐FMISO PET‐CT before and during week 3 of radiotherapy. The hypoxic volume (GTVhypo) is automatically generated by applying a subthresholding algorithm within the gross tumor volume (GTV) with a tumor to muscle standardized uptake value (SUV) ratio of 1.3 on the 18F‐FMISO PET‐CT scan. Two proton plans were generated for each patient, a standard plan to 70 Gy and dose escalation plan with upfront boost followed by standard 70GyE plan. The stereotactic boost was planned with single‐field uniform dose optimization using two fields to deliver 10 GyE in two fractions to GTVhypo. The standard plan was generated with IMPT with robust optimization to deliver 70GyE, 60GyE in 33 fractions using simultaneous integrated boost technique. A plan sum was generated for assessment. Results: Eight of nine patients showed tumor hypoxia on the baseline 18F‐FMISO PET‐CT scan. The mean hypoxic tumor volume was 3.9 cm3 (range.9–11.9cm3). The average SUVmax of the hypoxic volume was 2.2 (range 1.44–2.98). All the dose‐volume parameters met the planning objectives for target coverage. Dose escalation was not feasible in three of eight patients as the D0.03cc of temporal lobe was greater than 75GyE. Conclusions: The utility of boost to the hypoxic volume before standard course of radiotherapy with IMPT is dosimetrically feasible in selected patients. Clinical trials are warranted to determine the clinical outcomes of this approach. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Genomic analyses inform on migration events during the peopling of Eurasia

Author

Pagani, Luca, Lawson, Daniel John, Jagoda, Evelyn, Mörseburg, Alexander, Eriksson, Anders, Mitt, Mario, Clemente, Florian, Hudjashov, Georgi, DeGiorgio, Michael, Saag, Lauri, Wall, Jeffrey D, Cardona, Alexia, Mägi, Reedik, Sayres, Melissa A Wilson, Kaewert, Sarah, Inchley, Charlotte, Scheib, Christiana L, Järve, Mari, Karmin, Monika, Jacobs, Guy S, Antao, Tiago, Iliescu, Florin Mircea, Kushniarevich, Alena, Ayub, Qasim, Tyler-Smith, Chris, Xue, Yali, Yunusbayev, Bayazit, Tambets, Kristiina, Mallick, Chandana Basu, Saag, Lehti, Pocheshkhova, Elvira, Andriadze, George, Muller, Craig, Westaway, Michael C, Lambert, David M, Zoraqi, Grigor, Turdikulova, Shahlo, Dalimova, Dilbar, Sabitov, Zhaxylyk, Sultana, Gazi Nurun Nahar, Lachance, Joseph, Tishkoff, Sarah, Momynaliev, Kuvat, Isakova, Jainagul, Damba, Larisa D, Gubina, Marina, Nymadawa, Pagbajabyn, Evseeva, Irina, Atramentova, Lubov, Utevska, Olga, Ricaut, François-Xavier, Brucato, Nicolas, Sudoyo, Herawati, Letellier, Thierry, Cox, Murray P, Barashkov, Nikolay A, Škaro, Vedrana, Mulahasanovic´, Lejla, Primorac, Dragan, Sahakyan, Hovhannes, Mormina, Maru, Eichstaedt, Christina A, Lichman, Daria V, Abdullah, Syafiq, Chaubey, Gyaneshwer, Wee, Joseph TS, Mihailov, Evelin, Karunas, Alexandra, Litvinov, Sergei, Khusainova, Rita, Ekomasova, Natalya, Akhmetova, Vita, Khidiyatova, Irina, Marjanović, Damir, Yepiskoposyan, Levon, Behar, Doron M, Balanovska, Elena, Metspalu, Andres, Derenko, Miroslava, Malyarchuk, Boris, Voevoda, Mikhail, Fedorova, Sardana A, Osipova, Ludmila P, Lahr, Marta Mirazón, Gerbault, Pascale, Leavesley, Matthew, Migliano, Andrea Bamberg, Petraglia, Michael, Balanovsky, Oleg, Khusnutdinova, Elza K, Metspalu, Ene, Thomas, Mark G, Manica, Andrea, Nielsen, Rasmus, Villems, Richard, Willerslev, Eske, Kivisild, Toomas, and Metspalu, Mait

Subjects
Human Genome, Biotechnology, Genetics, Generic health relevance, Africa, Animals, Asia, Datasets as Topic, Estonia, Europe, Fossils, Gene Flow, Genetics, Population, Genome, Human, Genomics, Heterozygote, History, Ancient, Human Migration, Humans, Native Hawaiian or Other Pacific Islander, Neanderthals, New Guinea, Population Dynamics, Racial Groups, General Science & Technology
Abstract

High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history and refuelled the debate on the mutation rate in humans. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record, and admixture between AMHs and Neanderthals predating the main Eurasian expansion, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago.

Published
2016

10. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

Author

Mallick, Swapan, Li, Heng, Lipson, Mark, Mathieson, Iain, Gymrek, Melissa, Racimo, Fernando, Zhao, Mengyao, Chennagiri, Niru, Nordenfelt, Susanne, Tandon, Arti, Skoglund, Pontus, Lazaridis, Iosif, Sankararaman, Sriram, Fu, Qiaomei, Rohland, Nadin, Renaud, Gabriel, Erlich, Yaniv, Willems, Thomas, Gallo, Carla, Spence, Jeffrey P, Song, Yun S, Poletti, Giovanni, Balloux, Francois, van Driem, George, de Knijff, Peter, Romero, Irene Gallego, Jha, Aashish R, Behar, Doron M, Bravi, Claudio M, Capelli, Cristian, Hervig, Tor, Moreno-Estrada, Andres, Posukh, Olga L, Balanovska, Elena, Balanovsky, Oleg, Karachanak-Yankova, Sena, Sahakyan, Hovhannes, Toncheva, Draga, Yepiskoposyan, Levon, Tyler-Smith, Chris, Xue, Yali, Abdullah, M Syafiq, Ruiz-Linares, Andres, Beall, Cynthia M, Di Rienzo, Anna, Jeong, Choongwon, Starikovskaya, Elena B, Metspalu, Ene, Parik, Jüri, Villems, Richard, Henn, Brenna M, Hodoglugil, Ugur, Mahley, Robert, Sajantila, Antti, Stamatoyannopoulos, George, Wee, Joseph TS, Khusainova, Rita, Khusnutdinova, Elza, Litvinov, Sergey, Ayodo, George, Comas, David, Hammer, Michael F, Kivisild, Toomas, Klitz, William, Winkler, Cheryl A, Labuda, Damian, Bamshad, Michael, Jorde, Lynn B, Tishkoff, Sarah A, Watkins, W Scott, Metspalu, Mait, Dryomov, Stanislav, Sukernik, Rem, Singh, Lalji, Thangaraj, Kumarasamy, Pääbo, Svante, Kelso, Janet, Patterson, Nick, and Reich, David

Subjects
Human Genome, Genetics, Animals, Australia, Black People, Datasets as Topic, Genetic Variation, Genetics, Population, Genome, Human, Genomics, History, Ancient, Human Migration, Humans, Mutation Rate, Native Hawaiian or Other Pacific Islander, Neanderthals, New Guinea, Phylogeny, Racial Groups, Sequence Analysis, DNA, Species Specificity, Time Factors, General Science & Technology
Abstract

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.

Published
2016

11. Global diversity, population stratification, and selection of human copy-number variation.

Author

Krumm, Niklas, Huddleston, John, Coe, Bradley, Baker, Carl, Nordenfelt, Susanne, Bamshad, Michael, Jorde, Lynn, Posukh, Olga, Sahakyan, Hovhannes, Watkins, W, Yepiskoposyan, Levon, Abdullah, M, Bravi, Claudio, Capelli, Cristian, Hervig, Tor, Wee, Joseph, Tyler-Smith, Chris, van Driem, George, Romero, Irene, Jha, Aashish, Karachanak-Yankova, Sena, Toncheva, Draga, Comas, David, Kivisild, Toomas, Ruiz-Linares, Andres, Sajantila, Antti, Metspalu, Ene, Parik, Jüri, Villems, Richard, Starikovskaya, Elena, Ayodo, George, Beall, Cynthia, Di Rienzo, Anna, Hammer, Michael, Khusainova, Rita, Khusnutdinova, Elza, Klitz, William, Winkler, Cheryl, Labuda, Damian, Metspalu, Mait, Tishkoff, Sarah, Dryomov, Stanislav, Sukernik, Rem, Patterson, Nick, Reich, David, Eichler, Evan, Mallick, Swapan, Nelson, Bradley, Hormozdiari, Fereydoun, Henn, Brenna, and Sudmant, Peter

Subjects
Animals, Black People, DNA Copy Number Variations, Evolution, Molecular, Gene Duplication, Genome, Human, Hominidae, Humans, Native Hawaiian or Other Pacific Islander, Phylogeny, Polymorphism, Single Nucleotide, Population, Selection, Genetic, Sequence Deletion
Abstract

In order to explore the diversity and selective signatures of duplication and deletion human copy-number variants (CNVs), we sequenced 236 individuals from 125 distinct human populations. We observed that duplications exhibit fundamentally different population genetic and selective signatures than deletions and are more likely to be stratified between human populations. Through reconstruction of the ancestral human genome, we identify megabases of DNA lost in different human lineages and pinpoint large duplications that introgressed from the extinct Denisova lineage now found at high frequency exclusively in Oceanic populations. We find that the proportion of CNV base pairs to single-nucleotide-variant base pairs is greater among non-Africans than it is among African populations, but we conclude that this difference is likely due to unique aspects of non-African population history as opposed to differences in CNV load.

Published
2015

12. Global diversity, population stratification, and selection of human copy-number variation

Author

Sudmant, Peter H, Mallick, Swapan, Nelson, Bradley J, Hormozdiari, Fereydoun, Krumm, Niklas, Huddleston, John, Coe, Bradley P, Baker, Carl, Nordenfelt, Susanne, Bamshad, Michael, Jorde, Lynn B, Posukh, Olga L, Sahakyan, Hovhannes, Watkins, W Scott, Yepiskoposyan, Levon, Abdullah, M Syafiq, Bravi, Claudio M, Capelli, Cristian, Hervig, Tor, Wee, Joseph TS, Tyler-Smith, Chris, van Driem, George, Romero, Irene Gallego, Jha, Aashish R, Karachanak-Yankova, Sena, Toncheva, Draga, Comas, David, Henn, Brenna, Kivisild, Toomas, Ruiz-Linares, Andres, Sajantila, Antti, Metspalu, Ene, Parik, Jüri, Villems, Richard, Starikovskaya, Elena B, Ayodo, George, Beall, Cynthia M, Di Rienzo, Anna, Hammer, Michael F, Khusainova, Rita, Khusnutdinova, Elza, Klitz, William, Winkler, Cheryl, Labuda, Damian, Metspalu, Mait, Tishkoff, Sarah A, Dryomov, Stanislav, Sukernik, Rem, Patterson, Nick, Reich, David, and Eichler, Evan E

Subjects
Genetics, Human Genome, Animals, Black People, DNA Copy Number Variations, Evolution, Molecular, Gene Duplication, Genome, Human, Hominidae, Humans, Native Hawaiian or Other Pacific Islander, Phylogeny, Polymorphism, Single Nucleotide, Population, Selection, Genetic, Sequence Deletion, General Science & Technology
Abstract

In order to explore the diversity and selective signatures of duplication and deletion human copy-number variants (CNVs), we sequenced 236 individuals from 125 distinct human populations. We observed that duplications exhibit fundamentally different population genetic and selective signatures than deletions and are more likely to be stratified between human populations. Through reconstruction of the ancestral human genome, we identify megabases of DNA lost in different human lineages and pinpoint large duplications that introgressed from the extinct Denisova lineage now found at high frequency exclusively in Oceanic populations. We find that the proportion of CNV base pairs to single-nucleotide-variant base pairs is greater among non-Africans than it is among African populations, but we conclude that this difference is likely due to unique aspects of non-African population history as opposed to differences in CNV load.

Published
2015

15. The Americanization of a Filipina U.S. Navy Wife

Author

Wee, Joseph Ryan

Subjects
Filipina, Glass ceiling, Navy, Wife, immigrant, Asian American Studies, Ethnic Studies
Abstract

This story places a biography in the context of history. It describes the life of a Filipina immigrant to the United States during the Civil Rights movement and the Cold War in the context of U.S.-Philippine international relations and the boom of the aerospace industry.

Published
2012

16. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines

Author

Grégoire, Vincent, Evans, Mererid, Le, Quynh-Thu, Bourhis, Jean, Budach, Volker, Chen, Amy, Eisbruch, Abraham, Feng, Mei, Giralt, Jordi, Gupta, Tejpal, Hamoir, Marc, Helito, Juliana K., Hu, Chaosu, Hunter, Keith, Johansen, Jorgen, Kaanders, Johannes, Laskar, Sarbani Ghosh, Lee, Anne, Maingon, Philippe, Mäkitie, Antti, Micciche', Francesco, Nicolai, Piero, O'Sullivan, Brian, Poitevin, Adela, Porceddu, Sandro, Składowski, Krzysztof, Tribius, Silke, Waldron, John, Wee, Joseph, Yao, Min, Yom, Sue S., Zimmermann, Frank, and Grau, Cai

Published
2018
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17. International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma

Author

Lee, Anne W., Ng, Wai Tong, Pan, Jian Ji, Poh, Sharon S., Ahn, Yong Chan, AlHussain, Hussain, Corry, June, Grau, Cai, Grégoire, Vincent, Harrington, Kevin J., Hu, Chao Su, Kwong, Dora L., Langendijk, Johannes A., Le, Quynh Thu, Lee, Nancy Y., Lin, Jin Ching, Lu, Tai Xiang, Mendenhall, William M., O'Sullivan, Brian, Ozyar, Enis, Peters, Lester J., Rosenthal, David I., Soong, Yoke Lim, Tao, Yungan, Yom, Sue S., and Wee, Joseph T.

Published
2018
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21. Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis

Author

Petit, Claire, primary, Lee, Anne, additional, Ma, Jun, additional, Lacas, Benjamin, additional, Ng, Wai Tong, additional, Chan, Anthony T C, additional, Hong, Ruey-Long, additional, Chen, Ming-Yuan, additional, Chen, Lei, additional, Li, Wen-Fei, additional, Huang, Pei-Yu, additional, Tan, Terence, additional, Ngan, Roger K C, additional, Zhu, Guopei, additional, Mai, Hai-Qiang, additional, Hui, Edwin P, additional, Fountzilas, George, additional, Zhang, Li, additional, Carmel, Alexandra, additional, Kwong, Dora L W, additional, Moon, James, additional, Bourhis, Jean, additional, Auperin, Anne, additional, Pignon, Jean-Pierre, additional, Blanchard, Pierre, additional, Aupérin, Anne, additional, Benhamou, Ellen, additional, Chakrabandhu, Somvilai, additional, Chan, Anthony TC, additional, Chen, Qiu-Yan, additional, Chen, Yong, additional, Chappell, Richard J, additional, Choi, Horace, additional, Chua, Daniel TT, additional, Chua, Melvien Lee Kiang, additional, Higgins, Julian, additional, Hong, Ming Huang, additional, Hui, Edwin Pun, additional, Hsiao, Chin-Fu, additional, Kam, Michael, additional, Koliou, Georgia Angeliki, additional, Lai, Shu-Chuan, additional, Lam, Ka On, additional, LeBlanc, Michael L, additional, Lee, Anne WM, additional, Lee, Ho Fun Victor, additional, Li, Wen Fei, additional, Lim, Yoke, additional, Ma, Brigette, additional, Mo, Frankie, additional, Ngan, Roger, additional, Ollivier, Camille, additional, O'Sullivan, Brian, additional, Petit, Claire, additional, Poh, Sharon X, additional, Rücker, Gerta, additional, Sham, Jonathan, additional, Soong, Yoke Lim, additional, Sun, Ying, additional, Tang, Lin-Quan, additional, Tung, Yuk, additional, Wee, Joseph, additional, Wu, Xuang, additional, Xu, Tingting, additional, and Zhang, Yuan, additional

Published
2023
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22. 18F‐FMISO PET‐guided dose escalation with multifield optimization intensity‐modulated proton therapy in nasopharyngeal carcinoma

Author

Sommat, Kiattisa, primary, Tong, Aaron Kian Ti, additional, Ong, Ashley Li Kuan, additional, Hu, Jing, additional, Sin, Sze Yarn, additional, Lam, Winnie Wing Chuen, additional, Xie, Wanying, additional, Khor, Yiu Ming, additional, Lim, Cindy, additional, Lim, Tze Wei, additional, Selvarajan, Sathiyamoorthy, additional, Wang, Fuqiang, additional, Tan, Terence Wee Kiat, additional, Wee, Joseph Tien Seng, additional, Soong, Yoke Lim, additional, Fong, Kam Weng, additional, Hennedige, Tiffany, additional, and Hua, Thng Choon, additional

Published
2023
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25. Supplementary Materials from Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials

Author

Chen, Yu-Pei, primary, Tang, Ling-Long, primary, Yang, Qi, primary, Poh, Sharon-Shuxian, primary, Hui, Edwin P., primary, Chan, Anthony T.C., primary, Ong, Whee-Sze, primary, Tan, Terence, primary, Wee, Joseph, primary, Li, Wen-Fei, primary, Chen, Lei, primary, Ma, Brigette B.Y., primary, Tong, Macy, primary, Tan, Sze-Huey, primary, Cheah, Shie-Lee, primary, Fong, Kam-Weng, primary, Sommat, Kiattisa, primary, Soong, Yoke Lim, primary, Guo, Ying, primary, Lin, Ai-Hua, primary, Sun, Ying, primary, Hong, Ming-Huang, primary, Cao, Su-Mei, primary, Chen, Ming-Yuan, primary, and Ma, Jun, primary

Published
2023
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26. International recommendations for plasma Epstein-Barr virus DNA measurement in nasopharyngeal carcinoma in resource-constrained settings: lessons from the COVID-19 pandemic

Author

Lee, Victor Ho-Fun, primary, Adham, Marlinda, additional, Ben Kridis, Wala, additional, Bossi, Paolo, additional, Chen, Ming-Yuan, additional, Chitapanarux, Imjai, additional, Gregoire, Vincent, additional, Hao, Sheng Po, additional, Ho, Cheryl, additional, Ho, Gwo Fuang, additional, Kannarunimit, Danita, additional, Kwong, Dora Lai-Wan, additional, Lam, Ka-On, additional, Lam, Wai Kei Jacky, additional, Le, Quynh-Thu, additional, Lee, Anne Wing-Mui, additional, Lee, Nancy Y, additional, Leung, To-Wai, additional, Licitra, Lisa, additional, Lim, Darren Wan-Teck, additional, Lin, Jin-Ching, additional, Loh, Kwok Seng, additional, Lou, Pei-Jen, additional, Machiels, Jean-Pascal, additional, Mai, Hai-Qiang, additional, Mesía, Ricard, additional, Ng, Wai-Tong, additional, Ngan, Roger Kai-Cheong, additional, Tay, Joshua K, additional, Tsang, Raymond King-Yin, additional, Tong, Chi-Chung, additional, Wang, Hung-Ming, additional, and Wee, Joseph T, additional

Published
2022
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29. Intra-patient and inter-patient comparisons of DNA damage response biomarkers in Nasopharynx Cancer (NPC): analysis of NCC0901 randomised controlled trial of induction chemotherapy in locally advanced NPC

Author

Chua, Kevin Lee Min, Yeo, Eugenia Li Ling, Shihabudeen, Waseem Ahamed, Tan, Sze Huey, Shwe, Than Than, Ong, Enya Hui Wen, Lam, Paula Yeng Po, Soo, Khee Chee, Soong, Yoke Lim, Fong, Kam Weng, Tan, Terence Wee Kiat, Wee, Joseph Tien Seng, and Chua, Melvin Lee Kiang

Published
2018
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35. Meta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients

Author

Blanchard, Pierre, primary, Lee, Anne W.M., additional, Carmel, Alexandra, additional, Wai Tong, Ng, additional, Ma, Jun, additional, Chan, Anthony T.C., additional, Hong, Ruey Long, additional, Chen, Ming-Yuan, additional, Chen, Lei, additional, Li, Wen-Fei, additional, Huang, Pei-Yu, additional, Kwong, Dora L.W., additional, Poh, Sharon S.X., additional, Ngan, Roger, additional, Mai, Hai-Qiang, additional, Ollivier, Camille, additional, Fountzilas, George, additional, Zhang, Li, additional, Bourhis, Jean, additional, Aupérin, Anne, additional, Lacas, Benjamin, additional, Pignon, Jean-Pierre, additional, Blanchard, Pierre, additional, Benhamou, Ellen, additional, Chakrabandhu, Somvilai, additional, TC Chan, Anthony, additional, Chen, Qiu-Yan, additional, Chen, Yong, additional, Chappell, Richard J, additional, Choi, Horace, additional, TT Chua, Daniel, additional, Lee Kiang Chua, Melvin, additional, Higgins, Julian, additional, Hong, Ming-Huang, additional, Hong, Ruey-Long, additional, Pun Hui, Edwin, additional, Hsiao, C.F., additional, Kam, Michael, additional, Angeliki Koliou, Georgia, additional, LW Kwong, Dora, additional, Lai, Shu-Chuan, additional, On Lam, Ka, additional, LeBlanc, Michael L, additional, WM Lee, Anne, additional, Fun Victor Lee, Ho, additional, Fei Li, Wen, additional, Ma, Brigette, additional, Mo, Frankie, additional, Moon, James, additional, Tong Ng, Wai, additional, O'Sullivan, Brian, additional, Petit, Claire, additional, Pierre Pignon, Jean, additional, Poh, Sharon X., additional, Rücker, Gerta, additional, Sham, Jonathan, additional, Lim Soong, Yoke, additional, Sun, Ying, additional, Tan, Terence, additional, Tang, Lin-Quan, additional, Tung, Yuk, additional, Wee, Joseph, additional, Wu, Xuang, additional, Xu, Tingting, additional, Zhang, Yuan, additional, and Zhu, Guopei, additional

Published
2022
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36. HUMAN GENOMICS: Global diversity, population stratification, and selection of human copy-number variation

Author

Sudmant, Peter H., Mallick, Swapan, Nelson, Bradley J., Hormozdiari, Fereydoun, Krumm, Niklas, Huddleston, John, Coe, Bradley P., Baker, Carl, Nordenfelt, Susanne, Bamshad, Michael, Jorde, Lynn B., Posukh, Olga L., Sahakyan, Hovhannes, Watkins, Scott W., Yepiskoposyan, Levon, Abdullah, Syafiq M., Bravi, Claudio M., Capelli, Cristian, Hervig, Tor, Wee, Joseph T. S., Tyler-Smith, Chris, van Driem, George, Romero, Irene Gallego, Jha, Aashish R., Karachanak-Yankova, Sena, Toncheva, Draga, Comas, David, Henn, Brenna, Kivisild, Toomas, Ruiz-Linares, Andres, Sajantila, Antti, Metspalu, Ene, Parik, Jüri, Villems, Richard, Starikovskaya, Elena B., Ayodo, George, Beall, Cynthia M., Di Rienzo, Anna, Hammer, Michael F., Khusainova, Rita, Khusnutdinova, Elza, Klitz, William, Winkler, Cheryl, Labuda, Damian, Metspalu, Mait, Tishkoff, Sarah A., Dryomov, Stanislav, Sukernik, Rem, Patterson, Nick, Reich, David, and Eichler, Evan E.

Published
2015
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45. Abstract 2258: Germline variants associated with poorer disease prognosis in nasopharyngeal carcinoma

Author

Sim, Adelene Y.L., primary, Ong, Enya H.w., additional, Huang, Luo, additional, Low, Kar Perng, additional, Susanti, Dewi, additional, Tan, Terence W.k., additional, Fong, Kam Weng, additional, Soong, Yoke Lim, additional, Tan, Gek San, additional, Lim, Tony K.H., additional, Wee, Joseph T.s., additional, Lim, Darren W.t., additional, Iyer, N. Gopalakrishna, additional, Hwang, Jacqueline S.G., additional, Abazeed, Mohamed E., additional, Bei, Jin-Xin, additional, and Chua, Melvin L.k., additional

Published
2021
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46. International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma

Author

Ng, Wai Tong, primary, Soong, Yoke Lim, additional, Ahn, Yong Chan, additional, AlHussain, Hussain, additional, Choi, Horace C.W., additional, Corry, June, additional, Grégoire, Vincent, additional, Harrington, Kevin J., additional, Hu, Chao Su, additional, Jensen, Kenneth, additional, Kwong, Dora L., additional, Langendijk, Johannes A., additional, Le, Quynh Thu, additional, Lee, Nancy Y., additional, Lin, Jin Ching, additional, Lu, Tai Xiang, additional, Mendenhall, William M., additional, O’Sullivan, Brian, additional, Ozyar, Enis, additional, Pan, Jian Ji, additional, Peters, Lester J., additional, Poh, Sharon S., additional, Rosenthal, David I., additional, Sanguineti, Giuseppe, additional, Tao, Yungan, additional, Wee, Joseph T., additional, Yom, Sue S., additional, Chua, Melvin L.K., additional, and Lee, Anne W.M., additional

Published
2021
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49. International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Ng, Wai Tong, Soong, Yoke Lim, Ahn, Yong Chan, AlHussain, Hussain, Choi, Horace C W, Corry, June, Grégoire, Vincent, Harrington, Kevin J, Hu, Chao Su, Jensen, Kenneth, Kwong, Dora L, Langendijk, Johannes A, Le, Quynh Thu, Lee, Nancy Y, Lin, Jin Ching, Lu, Tai Xiang, Mendenhall, William M, O'Sullivan, Brian, Ozyar, Enis, Pan, Jian Ji, Peters, Lester J, Poh, Sharon S, Rosenthal, David I, Sanguineti, Giuseppe, Tao, Yungan, Wee, Joseph T, Yom, Sue S, Chua, Melvin L K, Lee, Anne W M, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Ng, Wai Tong, Soong, Yoke Lim, Ahn, Yong Chan, AlHussain, Hussain, Choi, Horace C W, Corry, June, Grégoire, Vincent, Harrington, Kevin J, Hu, Chao Su, Jensen, Kenneth, Kwong, Dora L, Langendijk, Johannes A, Le, Quynh Thu, Lee, Nancy Y, Lin, Jin Ching, Lu, Tai Xiang, Mendenhall, William M, O'Sullivan, Brian, Ozyar, Enis, Pan, Jian Ji, Peters, Lester J, Poh, Sharon S, Rosenthal, David I, Sanguineti, Giuseppe, Tao, Yungan, Wee, Joseph T, Yom, Sue S, Chua, Melvin L K, and Lee, Anne W M

Abstract

PURPOSE: Reirradiation for locally recurrent nasopharyngeal carcinoma (NPC) is challenging because prior radiation dose delivered in the first course is often close to the tolerance limit of surrounding normal structures. A delicate balance between achieving local salvage and minimizing treatment toxicities is needed. However, high-level evidence is lacking because available reports are mostly retrospective studies on small series of patients. Pragmatic consensus guidelines, based on an extensive literature search and the pooling of opinions by leading specialists, will provide a useful reference to assist decision-making for these difficult decisions. METHODS AND MATERIALS: A thorough review of available literature on recurrent NPC was conducted. A set of questions and preliminary draft guideline was circulated to a panel of international specialists with extensive experience in this field for voting on controversial areas and comments. A refined second proposal, based on a summary of the initial voting and different opinions expressed, was recirculated to the whole panel for review and reconsideration. The current guideline was based on majority voting after repeated iteration for final agreement. RESULTS: The initial round of questions showed variations in clinical practice even among the specialists, reflecting the lack of high-quality supporting data and the difficulties in formulating clinical decisions. Through exchange of comments and iterative revisions, recommendations with high-to-moderate agreement were formulated on general treatment strategies and details of reirradiation (including patient selection, targets contouring, dose prescription, and constraints). CONCLUSION: This paper provides useful reference on radical salvage treatment strategies for recurrent NPC and optimization of reirradiation through review of published evidence and consensus building. However, the final decision by the attending clinician must include full consideration of an indiv

Published
2021

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