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1. Long-term outcomes of operable stage III NSCLC in the pre-immunotherapy era: results from a pooled analysis of the SAKK 16/96, SAKK 16/00, SAKK 16/01, and SAKK 16/08 trials

Author

König, D., Schär, S., Vuong, D., Guckenberger, M., Furrer, K., Opitz, I., Weder, W., Rothschild, S.I., Ochsenbein, A., Zippelius, A., Addeo, A., Mark, M., Eboulet, E.I., Hayoz, S., Thierstein, S., Betticher, D.C., Ris, H.-B., Stupp, R., Curioni-Fontecedro, A., Peters, S., Pless, M., and Früh, M.

Published
2022
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5. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

Author

Jougon, J., Velly, J.-F., Rozé, H., Blanchard, E., Dromer, C., Antoine, M., Cappello, M., Ruiz, M., Sokolow, Y., Vanden Eynden, F., Van Nooten, G., Barvais, L., Berré, J., Brimioulle, S., De Backer, D., Créteur, J., Engelman, E., Huybrechts, I., Ickx, B., Preiser, T.J.C., Tuna, T., Van Obberghe, L., Vancutsem, N., Vincent, J.-L., De Vuyst, P., Etienne, I., Féry, F., Jacobs, F., Knoop, C., Vachiéry, J.L., Van den Borne, P., Wellemans, I., Amand, G., Collignon, L., Giroux, M., Angelescu, D., Chavanon, O., Hacini, R., Pirvu, A., Porcu, P., Albaladejo, P., Allègre, C., Bataillard, A., Bedague, D., Briot, E., Casez-Brasseur, M., Colas, D., Dessertaine, G., Durand, M., Francony, G., Hebrard, A., Marino, M.R., Oummahan, B., Protar, D., Rehm, D., Robin, S., Rossi-Blancher, M., Augier, C., Bedouch, P., Boignard, A., Bouvaist, H., Briault, A., Camara, B., Claustre, J., Chanoine, S., Dubuc, M., Quétant, S., Maurizi, J., Pavèse, P., Pison, C., Saint-Raymond, C., Wion, N., Chérion, C., Grima, R., Jegaden, O., Maury, J.-M., Tronc, F., Flamens, C., Paulus, S., Mornex, J.-F., Philit, F., Senechal, A., Glérant, J.-C., Turquier, S., Gamondes, D., Chalabresse, L., Thivolet-Bejui, F., Barnel, C., Dubois, C., Tiberghien, A., Le Pimpec-Barthes, F., Bel, A., Mordant, P., Achouh, P., Boussaud, V., Guillemain, R., Méléard, D., Bricourt, M.O., Cholley, B., Pezella, V., Brioude, G., D'Journo, X.B., Doddoli, C., Thomas, P., Trousse, D., Dizier, S., Leone, M., Papazian, L., Bregeon, F., Basire, A., Coltey, B., Dufeu, N., Dutau, H., Garcia, S., Gaubert, J.Y., Gomez, C., Laroumagne, S., Nieves, A., Picard, L.C., Reynaud-Gaubert, M., Secq, V., Mouton, G., Baron, O., Lacoste, P., Perigaud, C., Roussel, J.C., Danner, I., Haloun, A., Magnan, A., Tissot, A., Lepoivre, T., Treilhaud, M., Botturi-Cavaillès, K., Brouard, S., Danger, R., Loy, J., Morisset, M., Pain, M., Pares, S., Reboulleau, D., Royer, P.-J., Fabre, D., Fadel, E., Mercier, O., Mussot, S., Stephan, F., Viard, P., Cerrina, J., Dorfmuller, P., Ghigna, S.M., Hervén, Ph., Le Roy Ladurie, F., Le Pavec, J., Thomas de Montpreville, V., Lamrani, L., Castier, Y., Cerceau, P., Augustin, P., Jean-Baptiste, S., Boudinet, S., Montravers, P., Brugière, O., Dauriat, G., Jébrak, G., Mal, H., Marceau, A., Métivier, A.-C., Thabut, G., Lhuillier, E., Dupin, C., Bunel, V., Falcoz, P., Massard, G., Santelmo, N., Ajob, G., Collange, O., Helms, O., Hentz, J., Roche, A., Bakouboula, B., Degot, T., Dory, A., Hirschi, S., Ohlmann-Caillard, S., Kessler, L., Kessler, R., Schuller, A., Bennedif, K., Vargas, S., Stauder, J., Ali-Azouaou, S., Bonnette, P., Chapelier, A., Puyo, P., Sage, E., Bresson, J., Caille, V., Cerf, C., Devaquet, J., Dumans-Nizard, V., Felten, M.-L., Fischler, M., Si Larbi, A.-G., Leguen, M., Ley, L., Liu, N., Trebbia, G., De Miranda, S., Douvry, B., Gonin, F., Grenet, D., Hamid, A.M., Neveu, H., Parquin, F., Picard, C., Roux, A., Stern, M., Bouillioud, F., Cahen, P., Colombat, M., Dautricourt, C., Delahousse, M., D'Urso, B., Gravisse, J., Guth, A., Hillaire, S., Honderlick, P., Lequintrec, M., Longchampt, E., Mellot, F., Scherrer, A., Temagoult, L., Tricot, L., Vasse, M., Veyrie, C., Zemoura, L., Berjaud, J., Brouchet, L., Dahan, M., Mathe, F.O., Benahoua, H., DaCosta, M., Serres, I., Merlet-Dupuy, V., Grigoli, M., Didier, A., Murris, M., Crognier, L., Fourcade, O., Krueger, T., Ris, H.B., Gonzalez, M., Jolliet, Ph., Marcucci, C., Chollet, M., Gronchi, F., Courbon, C., Berutto, C., Manuel, O., Koutsokera, A., Aubert, J.-D., Nicod, L.P., Mouraux, S., Bernasconi, E., Pattaroni, C., Marsland, B.J., Soccal, P.M., Rochat, T., Lücker, L.M., Hillinger, S., Inci, I., Weder, W., Schuepbach, R., Zalunardo, M., Benden, C., Schuurmans, M.M., Gaspert, A., Holzmann, D., Müller, N., Schmid, C., Vrugt, B., Fritz, A., Maier, D., Deplanche, K., Koubi, D., Ernst, F., Paprotka, T., Schmitt, M., Wahl, B., Boissel, J.-P., Olivera-Botello, G., Trocmé, C., Toussaint, B., Bourgoin-Voillard, S., Sève, M., Benmerad, M., Siroux, V., Slama, R., Auffray, C., Charron, D., Lefaudeux, D., Pellet, J., Mouraux, Stéphane, Bernasconi, Eric, Pattaroni, Céline, Koutsokera, Angela, Aubert, John-David, Claustre, Johanna, Pison, Christophe, Royer, Pierre-Joseph, Magnan, Antoine, Kessler, Romain, Benden, Christian, Soccal, Paola M., Marsland, Benjamin J., and Nicod, Laurent P.

Published
2018
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6. Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: results from the ETOP Lungscape Project

Author

Kerr, K.M., Dafni, U., Schulze, K., Thunnissen, E., Bubendorf, L., Hager, H., Finn, S., Biernat, W., Vliegen, L., Losa, J.H., Marchetti, A., Cheney, R., Warth, A., Speel, E.-J., Blackhall, F., Monkhorst, K., Jantus Lewintre, E., Tischler, V., Clark, C., Bertran-Alamillo, J., Meldgaard, P., Gately, K., Wrona, A., Vandenberghe, P., Felip, E., De Luca, G., Savic, S., Muley, T., Smit, E.F., Dingemans, A.-M.C., Priest, L., Baas, P., Camps, C., Weder, W., Polydoropoulou, V., Geiger, T.R., Kammler, R., Sumiyoshi, T., Molina, M.A., Shames, D.S., Stahel, R.A., and Peters, S.

Published
2018
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8. CCL19 reduces tumour burden in a model of advanced lung cancer

Author

Hillinger, S, Yang, S-C, Batra, RK, Strieter, RM, Weder, W, Dubinett, SM, and Sharma, S

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Rare Diseases, Lung, 5.1 Pharmaceuticals, Adenocarcinoma, Bronchiolo-Alveolar, Animals, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Chemokine CCL19, Chemokines, CC, Disease Models, Animal, Flow Cytometry, Immunotherapy, Lung Neoplasms, Mice, Mice, Transgenic, lung cancer, immunotherapy, chemokines, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Epstein-Barr virus-induced molecule 1 ligand chemokine (CCL19) is a CC chemokine that chemoattracts both dendritic cells (DC) and T lymphocytes. We evaluated the antitumour efficacy of CCL19 in a murine model of spontaneous bronchoalveolar cell carcinoma. These transgenic mice (CC-10 TAg) express the SV40 large T antigen under the Clara Cell promoter, develop bilateral, multifocal, pulmonary carcinomas and die at 4 months owing to progressive pulmonary tumour burden. To mimic therapy in late-stage disease, 3-month-old transgenic mice were treated with recombinant CCL19 (0.5 microg dose(-1)) by intranodal (axillary lymph node region) injection three times per week for 4 weeks. CCL19 treatment led to a marked reduction in tumour burden with extensive mononuclear infiltration of the tumours compared to diluent treated controls. Flow cytometric analyses showed significant increases in CD4 and CD8T cell subsets as well as DC in the lungs of CCL19-treated mice. Lung tissue cytokine profiles showed a shift towards immune stimulatory molecules with a decrease in the immunosuppressive cytokine TGF-beta. Our findings show that CCL19 may serve as a potential immune stimulator and provide a strong rationale for the evaluation of CCL19 in cancer immunotherapy.

Published
2006

9. The IASLC Mesothelioma Staging Project: Proposals for the M Descriptors and for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Mesothelioma

Author

Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David, Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank C., Eberhardt, Wilfried Ernst Erich, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Toni, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan P., Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas W., Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie W., Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Jr., Travis, William D., Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Asamura, H., Batirel, H., Bille, A., Pastorino, U., Call, S., Cangir, A., Cedres, S., Friedberg, J., Galateau-Sallé, F., Hasagawa, S., Kernstine, K., Kindler, H., McCaughan, B., Nakano, T., Nowak, A., Ozturk, C. Atinkaya, Pass, H., de Perrot, M., Rea, F., Rice, D., Rintoul, R., Ruffini, E., Rusch, V., Spaggiari, L., Galetta, D., Syrigos, K., Thomas, C., van Meerbeeck, J.P., Nafteux, P., Vansteenkiste, J., Weder, W., Optiz, I., Yoshimura, M., Kindler, Hedy L., Nowak, Anna K., Pass, Harvey I., Rice, David C., McCaughan, Brian C., and Yoshimura, Masahiro

Published
2016
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10. The IASLC Mesothelioma Staging Project: Proposals for Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural Mesothelioma

Author

Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David, Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Eberhardt, Wilfried Ernst Erich, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Jr., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Asamura, H., Batirel, H., Bille, A., Pastorino, U., Call, S., Cangir, A., Cedres, S., Friedberg, J., Galateau-Salle, F., Hasagawa, S., Kernstine, K., Kindler, H., McCaughan, B., Nakano, T., Nowak, A., Ozturk, C. Atinkaya, Pass, H., de Perrot, M., Rea, F., Rice, D., Rintoul, R., Ruffini, E., Rusch, V., Spaggiari, L, Galetta, D, Syrigos, K., Thomas, C., van Meerbeeck, J., Nafteux, P., Vansteenkiste, J., Weder, W., Optiz, I., Yoshimura, M., Nowak, Anna K., Rice, David C., Pass, Harvey I., Kindler, Hedy L., Billé, Andrea, Rintoul, Robert C., Batirel, Hasan F., Thomas, Charles F., Friedberg, Joseph, Cedres, Susana, de Perrot, Marc, and Rusch, Valerie W.

Published
2016
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11. The IASLC Mesothelioma Staging Project: Improving Staging of a Rare Disease Through International Participation

Author

Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David, Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Eberhardt, Wilfried Ernst Erich, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Jr., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Asamura, H., Batirel, H., Bille, A., Pastorino, U., Call, S., Cangir, A., Cedres, S., Friedberg, J., Galateau-Salle, F., Hasagawa, Kernstine, K., Kindler, H., McCaughan, B., Nakano, T., Nowak, A., Ozturk, C. Atinkaya, Pass, H., de Perrot, M., Rea, F., Rice, D., Rintoul, R., Ruffini, E., Rusch, V., Spaggiari, L., Galetta, D., Syrigos, K., Thomas, C., van Meerbeeck, J., Vansteenkiste, J., Weder, W., Opitz, I., Yoshimura, M., Cangir, Ayten K., Waller, David, Weder, Walter, Hoffmann, Hans, van Meerbeeck, Jan P., and Rusch, Valerie W.

Published
2016
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13. 2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer

Author

Eberhardt, W.E.E., De Ruysscher, D., Weder, W., Le Péchoux, C., De Leyn, P., Hoffmann, H., Westeel, V., Stahel, R., Felip, E., Peters, S., Stahel, Rolf, Felip, Enriqueta, Peters, Solange, Kerr, Keith, Besse, Benjamin, Vansteenkiste, Johan, Eberhardt, Wilfried, Edelman, Martin, Mok, Tony, O'Byrne, Ken, Novello, Silvia, Bubendorf, Lukas, Marchetti, Antonio, Baas, Paul, Reck, Martin, Syrigos, Konstantinos, Paz-Ares, Luis, Smit, Egbert F., Meldgaard, Peter, Adjei, Alex, Nicolson, Marianne, Crinó, Lucio, Van Schil, Paul, Senan, Suresh, Faivre-Finn, Corinne, Rocco, Gaetano, Veronesi, Giulia, Douillard, Jean-Yves, Lim, Eric, Dooms, Christophe, Weder, Walter, De Ruysscher, Dirk, Le Pechoux, Cecile, De Leyn, Paul, and Westeel, Virginie

Published
2015
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16. 929MO Platform study of neoadjuvant durvalumab (D) alone or combined with novel agents in patients (pts) with resectable, early-stage non-small cell lung cancer (NSCLC): Pharmacodynamic correlates and circulating tumor DNA (ctDNA) dynamics in the NeoCOAST study

Author

Spicer, J., primary, Cascone, T., additional, Kar, G., additional, Zheng, Y., additional, Blando, J., additional, Tan, T.H., additional, Cheng, M., additional, Mager, R., additional, Hamid, O., additional, Soo-Hoo, Y., additional, Forde, P.M., additional, Weder, W., additional, Garcia Campelo, M.R., additional, Grenga, I., additional, Kumar, R., additional, and McGrath, L., additional

Published
2022
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20. Corrigendum to ‘Long-term outcomes of operable stage III NSCLC in the pre-immunotherapy era: results from a pooled analysis of the SAKK 16/96, SAKK 16/00, SAKK 16/01, and SAKK 16/08 trials’: [ESMO Open Volume 7, Issue 2, (2022), 100455]

Author

König, D., Schär, S., Vuong, D., Guckenberger, M., Furrer, K., Opitz, I., Weder, W., Rothschild, S.I., Ochsenbein, A., Zippelius, A., Addeo, A., Mark, M., Eboulet, E.I., Hayoz, S., Thierstein, S., Betticher, D.C., Ris, H.-B., Stupp, R., Curioni-Fontecedro, A., Peters, S., Pless, M., and Früh, M.

Published
2022
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22. Aktive Immunisierung mit IGN 101 als adjuvante Therapie nach radikaler Resektion des nicht kleinzelligen Bronchialkarzinoms: Ergebnisse einer prospektiven randomisierten doppelblinden plazebokontrollierten multizentrischen Studie

Author

Stoelben, Erich, Loibner, H., Weder, W., Schmoll, C., Bijelovic, M., Hasse, J., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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27. Smoking prevention intervention with school classes in university hospital by thoracic surgeon und pulmonologist. The Zurich prevention project

Author

Furrer, K, Schuurmans, M M, Hebeisen, M, Schulte, S, Schneiter, D, Weder, W, Opitz, I, Hillinger, S, Furrer, K, Schuurmans, M M, Hebeisen, M, Schulte, S, Schneiter, D, Weder, W, Opitz, I, and Hillinger, S

Abstract

Smoking prevention in schoolchildren to inform and prevent smoking initiation has been widely studied; however, the potential effect of interventions provided in a hospital setting is unknown. An intervention program named "Schoolchildren smoking prevention in the hospital" was developed in which the health aspects of smoking and its individual consequences were presented in an interactive informational event provided by a thoracic surgeon and a pulmonologist. We aimed to assess the feasibility and the short-term effect of smoking-related knowledge improvement in schoolchildren in a hospital setting. Scholars of 45 classes in Canton of Zurich in Switzerland filled in an anonymous 5-item questionnaire with questions on general knowledge about smoking. The answers were evaluated in this prospective observational cohort study. The primary endpoint was to compare the knowledge improvement by interpretation of answers before-and-after the smoking prevention intervention. Additionally, the performance of children was compared after setting up an overall score and specific subgroups according to gender and school-level. Between Jan 2010, and Oct 2019, schoolchildren aged 10 to 16 years participated in this intervention program and completed the questionnaire before (N = 1270) and after (N = 1264) the intervention. The amount of correctly answered questions increased from 40% (±20) before to 81% (±17), p < 0·0001 after the educational session. An intervention program on health effects of smoking provided by lung specialists in the hospital is feasible, well received, leads to a substantial increase of knowledge, and hopefully can be further explored in the development of smoking prevention programs for schoolchildren. Keywords: Adolescent; BASEC, Business Administration System for Ethics Committees; CI, Confidence interval; IQR, Interquartile range; OR, Odds radio; RCT, Randomized control trial; SD, Standard deviation; Schoolchildren; Smoking adverse effects; Smoking cessat

Published
2022

28. Corrigendum to 'Long-term outcomes of operable stage III NSCLC in the pre-immunotherapy era: results from a pooled analysis of the SAKK 16/96, SAKK 16/00, SAKK 16/01, and SAKK 16/08 trials': [ESMO Open Volume 7, Issue 2, (2022), 100455]

Author

König, D, Schär, S, Vuong, Diem; https://orcid.org/0000-0001-7153-4219, Guckenberger, Matthias; https://orcid.org/0000-0002-7146-9071, Furrer, K, Opitz, I, Weder, W, Rothschild, S I, Ochsenbein, A, Zippelius, A, Addeo, A, Mark, M, Eboulet, E I, Hayoz, S, Thierstein, S, Betticher, D C, Ris, H-B, Stupp, R, Curioni-Fontecedro, A, Peters, S, Pless, M, Früh, M, König, D, Schär, S, Vuong, Diem; https://orcid.org/0000-0001-7153-4219, Guckenberger, Matthias; https://orcid.org/0000-0002-7146-9071, Furrer, K, Opitz, I, Weder, W, Rothschild, S I, Ochsenbein, A, Zippelius, A, Addeo, A, Mark, M, Eboulet, E I, Hayoz, S, Thierstein, S, Betticher, D C, Ris, H-B, Stupp, R, Curioni-Fontecedro, A, Peters, S, Pless, M, and Früh, M

Published
2022

29. Long-term outcomes of operable stage III NSCLC in the pre-immunotherapy era: results from a pooled analysis of the SAKK 16/96, SAKK 16/00, SAKK 16/01, and SAKK 16/08 trials

Author

König, D, Schär, S, Vuong, Diem; https://orcid.org/0000-0001-7153-4219, Guckenberger, Matthias; https://orcid.org/0000-0002-7146-9071, Furrer, K, Opitz, I, Weder, W, Rothschild, S I, Ochsenbein, A, Zippelius, A, Addeo, A, Mark, M, Eboulet, E I, Hayoz, S, Thierstein, S, Betticher, D C, Ris, H-B, Stupp, R, Curioni-Fontecedro, A, Peters, S, Pless, M, Früh, M, König, D, Schär, S, Vuong, Diem; https://orcid.org/0000-0001-7153-4219, Guckenberger, Matthias; https://orcid.org/0000-0002-7146-9071, Furrer, K, Opitz, I, Weder, W, Rothschild, S I, Ochsenbein, A, Zippelius, A, Addeo, A, Mark, M, Eboulet, E I, Hayoz, S, Thierstein, S, Betticher, D C, Ris, H-B, Stupp, R, Curioni-Fontecedro, A, Peters, S, Pless, M, and Früh, M

Abstract

BACKGROUND Chemoradiotherapy with durvalumab consolidation has yielded excellent results in stage III non-small-cell lung cancer (NSCLC). Therefore, it is essential to identify patients who might benefit from a surgical approach. MATERIAL AND METHODS Data from 437 patients with operable stage III NSCLC enrolled in four consecutive Swiss Group for Clinical Cancer Research (SAKK) trials (16/96, 16/00, 16/01, 16/08) were pooled and outcomes were analyzed in 431 eligible patients. All patients were treated with three cycles of induction chemotherapy (cisplatin/docetaxel), followed in some patients by neoadjuvant radiotherapy (44 Gy, 22 fractions) (16/00, 16/01, 16/08) and cetuximab (16/08). RESULTS With a median follow-up time of 9.3 years (range 8.5-10.3 years), 5- and 10-year overall survival (OS) rates were 37% and 25%, respectively. Overall, 342 patients (79%) underwent tumor resection, with a complete resection (R0) rate of 80%. Patients (n = 272, 63%) with R0 had significantly longer OS compared to patients who had surgery but incomplete resection (64.8 versus 19.2 months, P < 0.001). OS for patients who achieved pathological complete remission (pCR) (n = 66, 15%) was significantly better compared to resected patients without pCR (86.5 versus 37.0 months, P = 0.003). For patients with pCR, the 5- and 10-year event-free survival and OS rates were 45.7% [95% confidence interval (CI) 32.8% to 57.7%] and 28.1% (95% CI 15.2% to 42.6%), and 58.2% (95% CI 45.2% to 69.2%) and 45.0% (95% CI 31.5% to 57.6%), respectively. CONCLUSION We report favorable long-term outcomes in patients with operable stage III NSCLC treated with neoadjuvant chemotherapy with cisplatin and docetaxel ± neoadjuvant sequential radiotherapy from four prospective SAKK trials. Almost two-third of the patients underwent complete resection after neoadjuvant therapy. We confirm R0 resection and pCR as important predictors of outcome.

Published
2022

32. Thorax und Gefäße

Author

Okada, M., Kozawa, S., Yoshida, M., Cassina, P. C., Jülke, M., Weder, W., Schröder, D. W., Elfeldt, R. J., Walz, M. K., Thürauf, N., Eigler, F.-W., Post, S., Allenberg, J. R., Kasprzak, P., Pließ, M., Raithel, D., Hartel, W., editor, and Hierholzer, G.

Published
1995
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44. P30.01 Extended Resections for Advanced Stages T3/T4 NSCLC After Neoadjuvant Treatment: Conclusions of SAKK Pooled Analysis (16/96, 16/00, 16/01)

Author

Furrer, K., primary, Weder, W., additional, Eboulet, E., additional, Betticher, D., additional, Pless, M., additional, Stupp, R., additional, Krueger, T., additional, Perentes, J.Y., additional, Schmid, R., additional, Lardinois, D., additional, Furrer, M., additional, Fruh, M., additional, Peters, S., additional, Curioni-Fontecedro, A., additional, Stahel, R., additional, Rothschild, S., additional, Hayoz, S., additional, Thierstein, S., additional, Biaggi, C., additional, and Opitz, I., additional

Published
2021
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45. Chirurgische Lungenvolumenreduktion

Author

Weder W, C Caviezel, D Franzen, University of Zurich, and Weder, W

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, 10255 Clinic for Thoracic Surgery, business.industry, 610 Medicine & health, respiratory system, Lung volume reduction surgery, respiratory tract diseases, Resection, 03 medical and health sciences, 0302 clinical medicine, 2740 Pulmonary and Respiratory Medicine, 030220 oncology & carcinogenesis, Medicine, 030211 gastroenterology & hepatology, Radiology, 10178 Clinic for Pneumology, business, Lung function, Pulmonologists
Abstract

Lung volume reduction surgery (LVRS) offers improvement in lung function, quality of life and even survival in well selected patients with severe emphysema. Patients with all types of emphysema morphology can profit from LVRS when certain selection criteria are present. Hyperinflation plays a key role in qualifying for the procedure. Candidate selection should be performed at high volume centers with a multidisciplinary emphysema board. Qualified thoracic surgeons together with pulmonologists and radiologists identify the suitable patient considering emphysema morphology with its target areas for resection, lung function parameters and cardiac comorbidities. This review outlines candidate selection, technique and results of LVRS to inform referring physicians how to screen und inform their patients.

Published
2018
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49. Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: first report of FAPME, a phase I clinical trial

Author

Hiltbrunner, S, Britschgi, C, Schuberth, P, Bankel, L, Nguyen-Kim, T D L, Gulati, P, Weder, W, Opitz, I, Lauk, O, Caviezel, C, Bachmann, H, Tabor, A, Schröder, P, Knuth, A, Münz, C, Stahel, R, Boyman, O, Renner, C, Petrausch, U, Curioni-Fontecedro, A, Hiltbrunner, S, Britschgi, C, Schuberth, P, Bankel, L, Nguyen-Kim, T D L, Gulati, P, Weder, W, Opitz, I, Lauk, O, Caviezel, C, Bachmann, H, Tabor, A, Schröder, P, Knuth, A, Münz, C, Stahel, R, Boyman, O, Renner, C, Petrausch, U, and Curioni-Fontecedro, A

Published
2021

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