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2. Synchronization of repolarization after cardiac resynchronization therapy: A combined clinical and modeling study

Author

Verzaal, N.J., Deursen, C.J.M. van, Pezzuto, S., Wecke, L., Everdingen, W.M. van, Vernooy, K., Delhaas, T., Auricchio, A., Prinzen, F.W., Verzaal, N.J., Deursen, C.J.M. van, Pezzuto, S., Wecke, L., Everdingen, W.M. van, Vernooy, K., Delhaas, T., Auricchio, A., and Prinzen, F.W.

Abstract

Contains fulltext : 283528.pdf (Publisher’s version ) (Open Access), INTRODUCTION: The changes in ventricular repolarization after cardiac resynchronization therapy (CRT) are poorly understood. This knowledge gap is addressed using a multimodality approach including electrocardiographic and echocardiographic measurements in patients and using patient-specific computational modeling. METHODS: In 33 patients electrocardiographic and echocardiographic measurements were performed before and at various intervals after CRT, both during CRT-ON and temporary CRT-OFF. T-wave area was calculated from vectorcardiograms, and reconstructed from the 12-lead electrocardiography (ECG). Computer simulations were performed using a patient-specific eikonal model of cardiac activation with spatially varying action potential duration (APD) and repolarization rate, fit to a patient's ECG. RESULTS: During CRT-ON T-wave area diminished within a day and remained stable thereafter, whereas QT-interval did not change significantly. During CRT-OFF T-wave area doubled within 5 days of CRT, while QT-interval and peak-to-end T-wave interval hardly changed. Left ventricular (LV) ejection fraction only increased significantly increased after 1 month of CRT. Computer simulations indicated that the increase in T-wave area during CRT-OFF can be explained by changes in APD following chronic CRT that are opposite to the change in CRT-induced activation time. These APD changes were associated with a reduction in LV dispersion in repolarization during chronic CRT. CONCLUSION: T-wave area during CRT-OFF is a sensitive marker for adaptations in ventricular repolarization during chronic CRT that may include a reduction in LV dispersion of repolarization.

Published
2022

4. Vragen voor parlementaire enquête Irak

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Contains fulltext : 46120.pdf (Publisher’s version ) (Closed access)

Published
2007

5. Heimwee naar de kruisraket

Author

Wecke, L.

Subjects
Onderzoek Studiecentrum voor Vredesvraagstukken
Abstract

Item does not contain fulltext 9 p.

Published
2000

6. Inkeer (Column)

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 67400.pdf (Publisher’s version ) (Open Access)

Published
2005

7. Leon Wecke over terrorisme

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 3 p.

Published
2005

8. Schrijven

Author

Wecke, L.

Published
2008

9. Verbeelding

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 2 p.

Published
2008

10. Gewonden tellen mee

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext

Published
2008

12. Een humane krijgsmacht?

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 5 p.

Published
2008

13. Onderscheid

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 1 p.

Published
2008

14. Baan

Author

Wecke, L.

Published
2008

16. Draagvlak

Author

Wecke, L.

Published
2008

17. Hobby

Author

Wecke, L.

Published
2008

18. Projecten als projectie

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 1 p.

Published
2008

19. Legitimation of military operations

Author

Wecke, L., Ribbelink, O.M., and Ribbelink, O.M.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext

Published
2008

20. Negatieve beelden en PTSS

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 1 p.

Published
2008

21. Amerikanen niet gek, Europeanen evenmin

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 68956.pdf (Publisher’s version ) (Open Access) C. Groenhuijsen Amerikanen zijn niet gek :Uitgeverij Balans ,2007 9789050188661

Published
2008

22. Terrorisme en onzekerheid

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 68705.pdf (Publisher’s version ) (Open Access) 3 p.

Published
2008

23. Ontwikkelingen naar wereldgezag

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 4 p.

Published
2008

24. Brood en Spelen

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext

Published
2008

25. Niet de vijf geven

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 68829.pdf (Publisher’s version ) (Open Access) 3 p.

Published
2008

26. CIA-vluchten vallen onder afspraak

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 14 juni 2007

Published
2007

28. Nederlanders, vredelievend en laf?

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext De Balie, 26 november 2007

Published
2007

31. Verenigde Staten en terrorisme

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext gastdocent Willem Post, Clingendael, 07 mei 2007

Published
2007

32. Discussiebijdrage over Nederlands veiligheidsbeleid

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext Symposium t.g.v. 25 jaar vredescentrum Eindhoven, 22 september 2007

Published
2007

33. Religie en geweld

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 2 p.

Published
2007

34. Missie ondermijnt legitimiteit leger

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 15 juli 2007

Published
2007

35. Andere veteranen

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext

Published
2007

39. Justitie en mediamacht

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 01 februari 2007

Published
2007

40. Te huur

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext

Published
2007

41. Democratie als legitimatie-instrument

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext college Legitimatie van Veiligheids- en Defensiebeleid, 12 januari 2007

Published
2007

42. Workshop Minorities, Conflict and Media

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext Workshop Minorities, Conflict and Media, 17 oktober 2007

Published
2007

48. Draagvlak slinkt na verliezen

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management
Abstract

Item does not contain fulltext 28 juni 2007

Published
2007

50. Maakt belofte aan VS altijd schuld?

Author

Wecke, L.

Subjects
Center for International Conflict-Analysis and -Management, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 45722.pdf (Publisher’s version ) (Open Access)

Published
2007

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