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1. Quantification of Mucosal Mast Cells in the Gastrointestinal Tract: A Primer for Practicing Pathologists

Author

Genta, Robert M., Turner, Kevin O., Collins, Margaret H., Wechsler, Joshua B., Arva, Nicoleta C., Pletneva, Maria A., Dellon, Evan S., and Walker, Marjorie M.

Subjects
Gastrointestinal system, Gastrointestinal diseases, Health
Abstract

* Context.--Mast cells are essential components of the immune system and play crucial pathogenetic roles in several digestive diseases, including mastocytic enterocolitis and eosinophilic gastrointestinal disorders. Pathologists have rarely been asked to evaluate the distribution and density of mast cells in gastrointestinal (GI) biopsy specimens. However, such requests are becoming more common because of an increasing awareness of the role of mast cells in functional GI disease and in both esophageal and nonesophageal eosinophilic gastrointestinal disorders. Objective.--To provide pathologists with tools to incorporate the assessment of mast cells in the evaluation of esophageal, gastric, and intestinal specimens by developing a systematic approach to their evaluation, counting, and reporting. Design.--This study consisted of a review of the literature followed by multiple consensus sessions to decide where to count mast cells and what a countable mast cell is. Results.--We reviewed 135 papers addressing the content of mast cells in the digestive tract, selected 21 that detailed how cells were counted (microscope lens, area of high-power fields, locations evaluated, type of cells considered as countable), and summarized their data in a table. Then, drawing from both the acceptable literature and our own extensive experience, we reached a tentative consensus on: (1) the normal numbers in the different segments of the GI tract; (2) the morphology of countable mast cells; and (3) the locations and strategies for counting them. Conclusions.--The result is a set of suggestions for reporting mast cell counts, their distribution, and their location in a way clinicians can understand and use for management decisions. (Arch Pathol Lab Med. 2024; 148:e25-e35; doi: 10.5858/arpa.2023-0070-OA), The discovery of mast cells and the gradual understanding of their role in the immune system have been described in fascinating detail by Blank et al. (1) First reported by [...]

Published
2024
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2. Long-term durability between parent and child patient-reported outcomes in eosinophilic esophagitis

Author

Martin, Lisa J., Zhang, Xue, Chehade, Mirna, Davis, Carla M., Dellon, Evan S., Falk, Gary W., Gupta, Sandeep K., Hirano, Ikuo, Hiremath, Girish S., Katzka, David A., Khoury, Paneez, Leung, John, Menard-Katcher, Paul, Gonsalves, Nirmala, Pesek, Robert D., Spergel, Jonathan M., Wechsler, Joshua B., Kliewer, Kara, Arva, Nicoleta C., Collins, Margaret H., Pletneva, Maria, Yang, Guang-Yu, Furuta, Glenn T., Rothenberg, Marc E., and Aceves, Seema S.

Published
2024
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3. Advances and ongoing challenges in eosinophilic gastrointestinal disorders presented at the CEGIR/TIGERs Symposium at the 2024 American Academy of Allergy, Asthma & Immunology meeting

Author

Wright, Benjamin L., Abonia, Juan Pablo, Abud, Edsel M., Aceves, Seema S., Ackerman, Steven J., Braskett, Melinda, Chang, Joy W., Chehade, Mirna, Constantine, Gregory M., Davis, Carla M., Dellon, Evan S., Doyle, Alfred D., Durban, Raquel, Hill, David A., Jensen, Elizabeth T., Kewalramani, Anupama, Khoury, Paneez, Klion, Amy D., Kottyan, Leah, Kuang, Fei Li, McGowan, Emily C., Ruffner, Melanie A., Spencer, Lisa A., Spergel, Jonathan M., Uchida, Amiko M., Wechsler, Joshua B., and Pesek, Robert D.

Published
2024
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4. Clinical and molecular correlates of the Index of Severity for Eosinophilic Esophagitis

Author

Sato, Hiroki, Dellon, Evan S., Aceves, Seema S., Arva, Nicoleta C., Chehade, Mirna, Collins, Margaret H., Davis, Carla M., Falk, Gary W., Furuta, Glenn T., Gonsalves, Nirmala P., Gupta, Sandeep K., Hirano, Ikuo, Hiremath, Girish, Katzka, David A., Khoury, Paneez, Leung, John, Menard-Katcher, Paul, Pesek, Robbie, Peterson, Kathryn A., Pletneva, Maria A., Spergel, Jonathan M., Wechsler, Joshua B., Yang, Guang-Yu, Rothenberg, Marc E., and Shoda, Tetsuo

Published
2024
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8. One-food versus 4-food elimination diet for pediatric eosinophilic esophagitis: A multisite randomized trial

Author

Kliewer, Kara L., Abonia, J. Pablo, Aceves, Seema S., Atkins, Dan, Bonis, Peter A., Capocelli, Kelley E., Chehade, Mirna, Collins, Margaret H., Dellon, Evan S., Fei, Lin, Furuta, Glenn T., Gupta, Sandeep K., Kagalwalla, Amir, Leung, John, Mir, Sabina, Mukkada, Vincent A., Pesek, Robbie, Rosenberg, Chen, Shoda, Tetsuo, Spergel, Jonathan M., Sun, Qin, Wechsler, Joshua B., Yang, Guang-Yu, and Rothenberg, Marc E.

Published
2024
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9. Nonepithelial Gene Expression Correlates With Symptom Severity in Adults With Eosinophilic Esophagitis

Author

Kim, Seung, Ben-Baruch Morgenstern, Netali, Osonoi, Kasumi, Aceves, Seema S., Arva, Nicoleta C., Chehade, Mirna, Collins, Margaret H., Dellon, Evan S., Falk, Gary W., Furuta, Glenn T., Gonsalves, Nirmala P., Gupta, Sandeep K., Hirano, Ikuo, Hiremath, Girish, Katzka, David A., Khoury, Paneez, Leung, John, Pesek, Robbie, Peterson, Kathryn A., Pletneva, Maria A., Spergel, Jonathan M., Wechsler, Joshua B., Yang, Guang-Yu, Rothenberg, Marc E., and Shoda, Tetsuo

Published
2024
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10. Esophageal Epithelium and Lamina Propria Are Unevenly Involved in Eosinophilic Esophagitis

Author

Hiremath, Girish, Sun, Lili, Collins, Margaret H., Bonis, Peter A., Arva, Nicoleta C., Capocelli, Kelley E., Chehade, Mirna, Davis, Carla M., Falk, Gary W., Gonsalves, Nirmala, Gupta, Sandeep K., Hirano, Ikuo, Leung, John, Khoury, Paneez, Mukkada, Vincent A., Martin, Lisa J., Spergel, Jonathan M., Wechsler, Joshua B., Yang, Guang-Yu, Aceves, Seema S., Furuta, Glenn T., Rothenberg, Marc.E., Koyama, Tatsuki, and Dellon, Evan S.

Published
2023
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11. Development of a Practical Guide to Implement and Monitor Diet Therapy for Eosinophilic Esophagitis

Author

Aceves, Seema S., Abonia, Pablo, Atkins, Dan, Bonis, Peter A., Chehade, Mirna, Falk, Gary W., Furuta, Glenn T., Gupta, Sandeep K., Kagalwalla, Amir F., Kodroff, Ellyn, Kyle, Scholeigh, Leung, John, Menard-Katcher, Paul, Mir, Sabina, Mukkada, Vincent A., Pesek, Robert, Rothenberg, Marc E., Spergel, Jonathan M., Strobel, Mary Jo, Wechsler, Joshua B., Chang, Joy W., Kliewer, Kara, Haller, Emily, Lynett, Amanda, Doerfler, Bethany, Katzka, David A., Peterson, Kathryn A., Dellon, Evan S., and Gonsalves, Nirmala

Published
2023
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12. Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study

Author

Shoda, Tetsuo, Wen, Ting, Caldwell, Julie M, Collins, Margaret H, Besse, John A, Osswald, Garrett A, Abonia, J Pablo, Arva, Nicoleta C, Atkins, Dan, Capocelli, Kelley E, Dellon, Evan S, Falk, Gary W, Gonsalves, Nirmala, Gupta, Sandeep K, Hirano, Ikuo, Mukkada, Vincent A, Putnam, Philip E, Sheridan, Rachel M, Spergel, Amanda K Rudman, Spergel, Jonathan M, Wechsler, Joshua B, Yang, Guang-Yu, Aceves, Seema S, Furuta, Glenn T, Rothenberg, Marc E, and Researchers, Consortium of Eosinophilic Gastrointestinal Disease

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Clinical Research, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Adolescent, Adult, Biomarkers, Child, Cytokines, Endoscopy, Gastrointestinal, Enteritis, Eosinophilia, Female, Gastritis, Humans, Male, Biomarker, diagnostic panel, eosinophil, eosinophilic gastritis, transcriptome, Consortium of Eosinophilic Gastrointestinal Disease Researchers, Immunology, Allergy
Abstract

BackgroundEosinophilic gastritis (EG) is a clinicopathologic disorder with marked gastric eosinophilia and clinical symptoms. There is an unmet need among patients with EG for more precise diagnostic tools.ObjectiveWe aimed to develop tissue- and blood-based diagnostic platforms for EG.MethodsPatients with EG and control subjects without EG were enrolled across 9 Consortium of Eosinophilic Gastrointestinal Disease Researchers-associated sites. An EG Diagnostic Panel (EGDP; gastric transcript subset) and EG blood biomarker panel (protein multiplex array) were analyzed. EGDP18 scores were derived from the expression of 18 highly dysregulated genes, and blood EG scores were derived from dysregulated cytokine/chemokine levels.ResultsGastric biopsy specimens and blood samples from 185 subjects (patients with EG, n = 74; control subjects without EG, n = 111) were analyzed. The EGDP (1) identified patients with active EG (P < .0001, area under the curve ≥ 0.95), (2) effectively monitored disease activity in longitudinal samples (P = .0078), (3) highly correlated in same-patient samples (antrum vs body, r = 0.85, P < .0001), and (4) inversely correlated with gastric peak eosinophil levels (r = -0.83, P < .0001), periglandular circumferential collars (r = -0.73, P < .0001), and endoscopic nodularity (r = -0.45, P < .0001). For blood-based platforms, eotaxin-3, thymus and activation-regulated chemokine, IL-5, and thymic stromal lymphopoietin levels were significantly increased. Blood EG scores (1) distinguished patients with EG from control subjects without EG (P < .0001, area under the curve ≥ 0.91), (2) correlated with gastric eosinophil levels (plasma: r = 0.72, P = .0002; serum: r = 0.54, P = .0015), and (3) inversely correlated with EGDP18 scores (plasma: r = -0.64, P = .0015; serum: r = -0.46, P = .0084). Plasma eotaxin-3 levels strongly associated with gastric CCL26 expression (r = 0.81, P < .0001).ConclusionWe developed tissue- and blood-based platforms for assessment of EG and uncovered robust associations between specific gastric molecular profiles and histologic and endoscopic features, providing insight and clinical readiness tools for this emerging rare disease.

Published
2020

15. Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes

Author

Muir, Amanda B, Jensen, Elizabeth T, Wechsler, Joshua B, Menard-Katcher, Paul, Falk, Gary W, Aceves, Seema S, Furuta, Glenn T, Dellon, Evan S, Rothenberg, Mark E, and Spergel, Jonathan M

Subjects
Biomedical and Clinical Sciences, Immunology, Adult, Child, Colitis, Colon, Diagnosis, Differential, Diagnostic Errors, Eosinophilia, Eosinophils, Humans, International Classification of Diseases, Retrospective Studies, United States
Published
2019

16. International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Author

Dellon, Evan S., Gonsalves, Nirmala, Abonia, J. Pablo, Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Attwood, Stephen E., Auth, Marcus K.H., Bailey, Dominique D., Biederman, Luc, Blanchard, Carine, Bonis, Peter A., Bose, Paroma, Bredenoord, Albert J., Chang, Joy W., Chehade, Mirna, Collins, Margaret H., Di Lorenzo, Carlo, Dias, Jorge Amil, Dohil, Ranjan, Dupont, Christophe, Falk, Gary W., Ferreira, Cristina T., Fox, Adam T., Genta, Robert M., Greuter, Thomas, Gupta, Sandeep K., Hirano, Ikuo, Hiremath, Girish S., Horsley-Silva, Jennifer L., Ishihara, Shunji, Ishimura, Norihisa, Jensen, Elizabeth T., Gutiérrez-Junquera, Carolina, Katzka, David A., Khoury, Paneez, Kinoshita, Yoshikazu, Kliewer, Kara L., Koletzko, Sibylle, Leung, John, Liacouras, Chris A., Lucendo, Alfredo J., Martin, Lisa J., McGowan, Emily C., Menard-Katcher, Calies, Metz, David C., Miller, Talya L., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Murch, Simon, Nhu, Quan M., Nomura, Ichiro, Nurko, Samuel, Ohtsuka, Yoshikazu, Oliva, Salvatore, Orel, Rok, Papadopoulou, Alexandra, Patel, Dhyanesh A., Pesek, Robert D., Peterson, Kathryn A., Philpott, Hamish, Putnam, Philip E., Richter, Joel E., Rosen, Rachel, Ruffner, Melanie A., Safroneeva, Ekaterina, Schreiner, Philipp, Schoepfer, Alain, Schroeder, Shauna R., Shah, Neil, Souza, Rhonda F., Spechler, Stuart J., Spergel, Jonathan M., Straumann, Alex, Talley, Nicholas J., Thapar, Nikhil, Vandenplas, Yvan, Venkatesh, Rajitha D., Vieira, Mario C., von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Wershil, Barry K., Wright, Benjamin L., Yamada, Yoshiyuki, Yang, Guang-Yu, Zevit, Noam, Rothenberg, Marc E., Furuta, Glenn T., and Aceves, Seema S.

Published
2022
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19. Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study

Author

Pablo Abonia, J., Aceves, Seema, Almonte, Samuel, Andrews, Rachel, Anvari, Sara, Arrington, Ashley, Arva, Nicoleta, Atkins, Fred, Bailey, Dominique, Berry, Alexis, Besl, Bridget, Bolton, Scott, Bonis, Peter, Book, Wendy, Bray, Kimberly, Brown, Teresa, Burger, Cassandra, Burke, Deirdre, Cahoon, Jonathon, Capocelli, Kelley, Chehade, Mirna, Chiou, Eric, Collins, Margaret, Davis, Carla, Dellon, Evan, DeMarshall, Maureen, DiTommaso, Lauren, Dohil, Ranjan, Eby, Michael, Falk, Gary, Fleischer, David, Foote, Heather, Foss, Kelci, Friedlander, Joel, Fulkerson, Patricia, Furuta, Glenn, Geno, Debra, Gonsalves, Nirmala, Greuter, Thomas, Gupta, Sandeep, Hamilton, Frank, Harris, Kirk, Harris, Jennifer, Hirano, Ikuo, Hiremath, Girish, Holland-Thomas, Nicole, Jacinto, Lea, Kagalwalla, Amir, Kaseta, Timothy, Katzka, David, Keeley, Kaitlin, Khosh-Hemmat, Emad, Khoury, Paneez, King, Eileen, Kliewer, Kara, Klion, Amy, Knowles, Jennifer, Kocher, Kendra, Kodroff, Ellyn, Krischer, Jeffrey, Kyle, Shay, Leung, John, Levy, Meredith, Liacouras, Chris, Mack, Denise, Martin, Lisa, Martin, Ellen, McCright-Gill, Talaya, Menard-Katcher, Paul, Menard-Katcher, Calies, Mendoza, Gabriela, Mingler, Melissa, Minnicozzi, Mike, Muir, Amanda, Mukkada, Vincent, Murray-Petzold, Cristin, Newbury, Robert, Nhu, Quan, Olive, Anthony, Oyibo, Oghenekpaobor (Joel), Paliana, Allisa, Pan, Zhaoxing, Pesek, Robbie, Peterson, Kathryn, Poppendeck, Heidi, Putnam, Philip, Rivera, Fabian, Rothenberg, Marc, Spergel, Amanda Rudman, Sable, Kathleen, Schoepfer, Alain, Scott, Melissa, Sheridan, Rachel, Sinanovic, Selma, Spergel, Jonathan, Strobel, Mary Jo, Sun, Kiki, Tasco, Amy, Tholen, Crystal, Thompson, Katherine, Tomkinson, Tiffany, Tran, Daisy, Tylicki, Alexandra, Urv, Tiina, Wang, Mei-Lun, Wechsler, Joshua, Wershil, Barry, Wheatley, Lisa, Wilkey, Leah, Yang, Guang-Yu, Zalewski, Angelika, Zicarelli, Amy, Shoda, Tetsuo, Collins, Margaret H., Rochman, Mark, Wen, Ting, Caldwell, Julie M., Mack, Lydia E., Osswald, Garrett A., Besse, John A., Haberman, Yael, Aceves, Seema S., Arva, Nicoleta C., Capocelli, Kelley E., Davis, Carla M., Dellon, Evan S., Falk, Gary W., Gupta, Sandeep K., Mukkada, Vincent A., Putnam, Philip E., Spergel, Jonathan M., Wechsler, Joshua B., Furuta, Glenn T., Denson, Lee A., and Rothenberg, Marc E.

Published
2022
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20. Somatic, emotional, and gastrointestinal symptom severity are increased among children and adolescents with COVID‐19.

Author

Wechsler, Joshua B., Berken, Jonathan A., Keeley, Kaitlyn, Singer, Wolfgang, Jhaveri, Ravi, Katz, Ben Z., Fortunato, John E., and Saps, Miguel

Subjects
*POST-acute COVID-19 syndrome, *ELECTRONIC health records, *CHILDREN'S hospitals, *EOSINOPHILIC esophagitis, *DIAGNOSTIC use of polymerase chain reaction
Abstract

Background: Post‐infectious disorders of gut‐brain interaction (PI‐DGBI) have significant impact on children and adolescents. The effect of COVID‐19 on PI‐DGBI‐associated symptoms in this population, however, is unknown. Methods: We performed electronic medical record searches to identify patients 8–17 years old with a SARS‐CoV2 PCR test at Lurie Children's Hospital between November 2020 and March 2021 (cohort 1) and April–October 2021 (cohort 2). Questionnaires were administered to assess symptoms prior to and 3 months following the test. This included the Pediatric Eosinophilic Esophagitis Symptom Score (PEESS), questionnaire of pediatric gastrointestinal symptoms—Rome IV, Nausea Profile (NP), dyspepsia symptom survey (DSS), nausea severity profile (NSP), and Pediatric Quality of Life Inventory (PedsQL). We grouped patients based on the presence of symptoms prior to COVID‐19 test or the test result. Results: One hundred and ninety‐six parent(s) or guardian(s) in cohort 1 and 274 in cohort 2 completed surveys and self‐reported their child's COVID‐19 result. Cohort 1 had increased PEESS and DSS scores, lower PedsQL scores, and increased frequency of abdominal pain disorders among patients with symptoms prior to COVID‐19 testing. Both cohorts had increased NP and NSP scores among patients with symptoms prior to COVID‐19 testing that was highest among patients with a positive COVID‐19 test. Abdominal pain and diarrhea prior to COVID‐19 testing predicted higher NP scores. Conclusions: Among symptomatic COVID‐19 tested children, we found increased severity of nausea‐associated somatic, emotional, and gastrointestinal symptoms in the 3 months following the test that was most increased among patients with a positive COVID‐19 test. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell–Fibroblast Crosstalk

Author

Abonia, J. Pablo, Aceves, Seema, Almonte, Samuel, Andrews, Rachel, Arrington, Ashley, Arva, Nicoleta, Atkins, Fred, Bailey, Dominique, Berry, Alexis, Besl, Bridget, Bolton, Scott, Bonis, Peter, Book, Wendy, Bray, Kimberly, Brown, Teresa, Burger, Cassandra, Burke, Deirdre, Cahoon, Jonathon, Capocelli, Kelley, Chehade, Mirna, Collins, Margaret, Davis, Carla, Dellon, Evan, DeMarshall, Maureen, DiTommaso, Lauren, Dohil, Ranjan, Eby, Michael, Falk, Gary, Fleischer, David, Foote, Heather, Foss, Kelci, Friedlander, Joel, Fulkerson, Patricia, Furuta, Glenn, Geno, Debra, Gonsalves, Nirmala, Greuter, Thomas, Gupta, Sandeep, Hamilton, Frank, Harris, Kirk, Harris, Jennifer, Hirano, Ikuo, Hiremath, Girish, Holland-Thomas, Nicole, Jacinto, Lea, Kagalwalla, Amir, Kaseta, Timothy, Katzka, David, Keeley, Kaitlin, Khosh-Hemmat, Emad, Khoury, Paneez, King, Eileen, Kliewer, Kara, Klion, Amy, Knowles, Jennifer, Kocher, Kendra, Kodroff, Ellyn, Krischer, Jeffrey, Kyle, Shay, Leung, John, Levy, Meredith, Liacouras, Chris, Mack, Denise, Martin, Lisa, Martin, Ellen, McCright-Gill, Talaya, Menard-Katcher, Paul, Menard-Katcher, Calies, Mendoza, Gabriela, Mingler, Melissa, Minnicozzi, Mike, Muir, Amanda, Mukkada, Vincent, MurrayPetzold, Cristin, Newbury, Robert, Nhu, Quan, Oyibo, Oghenekpaobor (Joel), Paliana, Allisa, Pan, Zhaoxing, Pesek, Robbie, Peterson, Kathryn, Poppendeck, Heidi, Putnam, Philip, Rivera, Fabian, Rothenberg, Marc, Spergel, Amanda Rudman, Sable, Kathleen, Schoepfer, Alain, Scott, Melissa, Sheridan, Rachel, Sinanovic, Selma, Spergel, Jonathan, Strobel, MaryJo, Sun, Kiki, Tasco, Amy, Tholen, Crystal, Thompson, Katherine, Tomkinson, Tiffany, Tran, Daisy, Tylicki, Alexandra, Urv, Tiina, Wang, Mei-Lun, Wechsler, Joshua, Wershil, Barry, Wheatley, Lisa, Wilkey, Leah, Yang, Guang-Yu, Zalewski, Angelika, Zicarelli, Amy, Shoda, Tetsuo, Wen, Ting, Caldwell, Julie M., Ben-Baruch Morgenstern, Netali, Osswald, Garrett A., Rochman, Mark, Mack, Lydia E., Felton, Jennifer M., Arva, Nicoleta C., Atkins, Dan, Bonis, Peter A., Capocelli, Kelley E., Collins, Margaret H., Dellon, Evan S., Falk, Gary W., Gupta, Sandeep K., Menard-Katcher, Paul A., Mukkada, Vincent A., Putnam, Philip E., Rudman Spergel, Amanda K., Spergel, Jonathan M., Wechsler, Joshua B., Aceves, Seema S., Furuta, Glenn T., and Rothenberg, Marc E.

Published
2022
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22. Mucosal Microbiota Associated With Eosinophilic Esophagitis and Eosinophilic Gastritis

Author

Furuta, Glenn T., Fillon, Sophie A., Williamson, Kayla M., Robertson, Charles E., Stevens, Mark J., Aceves, Seema S., Arva, Nicoleta C., Chehade, Mirna, Collins, Margaret H., Davis, Carla M., Dellon, Evan S., Falk, Gary W., Gonsalves, Nirmala, Gupta, Sandeep K., Hirano, Ikuo, Khoury, Paneez, Leung, John, Martin, Lisa J., Menard-Katcher, Paul, Mukkada, Vincent A., Peterson, Kathryn, Spergel, Jonathan M., Wechsler, Joshua B., Yang, Guang-Yu, Rothenberg, Marc E., and Harris, J. Kirk

Published
2023
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23. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference

Author

Dellon, Evan S, Liacouras, Chris A, Molina-Infante, Javier, Furuta, Glenn T, Spergel, Jonathan M, Zevit, Noam, Spechler, Stuart J, Attwood, Stephen E, Straumann, Alex, Aceves, Seema S, Alexander, Jeffrey A, Atkins, Dan, Arva, Nicoleta C, Blanchard, Carine, Bonis, Peter A, Book, Wendy M, Capocelli, Kelley E, Chehade, Mirna, Cheng, Edaire, Collins, Margaret H, Davis, Carla M, Dias, Jorge A, Di Lorenzo, Carlo, Dohil, Ranjan, Dupont, Christophe, Falk, Gary W, Ferreira, Cristina T, Fox, Adam, Gonsalves, Nirmala P, Gupta, Sandeep K, Katzka, David A, Kinoshita, Yoshikazu, Menard-Katcher, Calies, Kodroff, Ellyn, Metz, David C, Miehlke, Stephan, Muir, Amanda B, Mukkada, Vincent A, Murch, Simon, Nurko, Samuel, Ohtsuka, Yoshikazu, Orel, Rok, Papadopoulou, Alexandra, Peterson, Kathryn A, Philpott, Hamish, Putnam, Philip E, Richter, Joel E, Rosen, Rachel, Rothenberg, Marc E, Schoepfer, Alain, Scott, Melissa M, Shah, Neil, Sheikh, Javed, Souza, Rhonda F, Strobel, Mary J, Talley, Nicholas J, Vaezi, Michael F, Vandenplas, Yvan, Vieira, Mario C, Walker, Marjorie M, Wechsler, Joshua B, Wershil, Barry K, Wen, Ting, Yang, Guang-Yu, Hirano, Ikuo, and Bredenoord, Albert J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Food Allergies, Digestive Diseases, Clinical Research, Algorithms, Consensus, Diagnostic Techniques, Digestive System, Eosinophilic Esophagitis, Gastroenterology, Humans, Predictive Value of Tests, Prognosis, Proton Pump Inhibitors, Diagnosis, Esophageal Eosinophilia, Proton Pump Inhibitor, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsOver the last decade, clinical experiences and research studies raised concerns regarding use of proton pump inhibitors (PPIs) as part of the diagnostic strategy for eosinophilic esophagitis (EoE). We aimed to clarify the use of PPIs in the evaluation and treatment of children and adults with suspected EoE to develop updated international consensus criteria for EoE diagnosis.MethodsA consensus conference was convened to address the issue of PPI use for esophageal eosinophilia using a process consistent with standards described in the Appraisal of Guidelines for Research and Evaluation II. Pediatric and adult physicians and researchers from gastroenterology, allergy, and pathology subspecialties representing 14 countries used online communications, teleconferences, and a face-to-face meeting to review the literature and clinical experiences.ResultsSubstantial evidence documented that PPIs reduce esophageal eosinophilia in children, adolescents, and adults, with several mechanisms potentially explaining the treatment effect. Based on these findings, an updated diagnostic algorithm for EoE was developed, with removal of the PPI trial requirement.ConclusionsEoE should be diagnosed when there are symptoms of esophageal dysfunction and at least 15 eosinophils per high-power field (or approximately 60 eosinophils per mm2) on esophageal biopsy and after a comprehensive assessment of non-EoE disorders that could cause or potentially contribute to esophageal eosinophilia. The evidence suggests that PPIs are better classified as a treatment for esophageal eosinophilia that may be due to EoE than as a diagnostic criterion, and we have developed updated consensus criteria for EoE that reflect this change.

Published
2018

24. New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting

Author

Spergel, Jonathan M, Aceves, Seema S, Kliewer, Kara, Gonsalves, Nirmala, Chehade, Mirna, Wechsler, Joshua B, Groetch, Marion, Friedlander, Joshua, Dellon, Evan S, Book, Wendy, Hirano, Ikuo, Muir, Amanda B, Cianferoni, Antonella, Spencer, Lisa, Liacouras, Chris A, Cheng, Edaire, Kottyan, Leah, Wen, Ting, Platts-Mills, Thomas, and Rothenberg, Marc E

Subjects
Biomedical and Clinical Sciences, Immunology, Asthma, Food Allergies, Vaccine Related, Digestive Diseases, Lung, Respiratory, Inflammatory and immune system, Allergy and Immunology, Enteritis, Eosinophilia, Gastritis, Gastroenterology, Humans, Eosinophilic esophagitis, food allergy, treatment, diagnosis, Allergy
Abstract

The Consortium of Eosinophilic Gastrointestinal Diseases and the International Gastrointestinal Eosinophil Researchers organized a day-long symposium at the recent 2018 Annual Meeting of the American Academy of Allergy, Asthma & Immunology, which was coupled for the first time with the World Allergy Organization meeting to create an international platform. The symposium featured experts in many facets of eosinophilic gastrointestinal diseases, including allergy, immunology, gastroenterology, pathology, and nutrition, and was a well-attended event. The basic science, genetics, cellular immunology, and clinical features of the diseases, with a focus on epithelial, eosinophil, and mast cell responses, as well as current and emerging treatment options, were reviewed. Here we briefly review some of the highlights of the material presented at the meeting.

Published
2018

31. Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

Author

Legrand, Fanny, Cao, Yun, Wechsler, Joshua B., Zhu, Xiang, Zimmermann, Nives, Rampertaap, Shakuntala, Monsale, Joseph, Romito, Kimberly, Youngblood, Bradford A., Brock, Emily C., Makiya, Michelle A., Tomasevic, Nenad, Bebbington, Christopher, Maric, Irina, Metcalfe, Dean D., Bochner, Bruce S., and Klion, Amy D.

Published
2019
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36. Efficacy of a 4-Food Elimination Diet for Children With Eosinophilic Esophagitis

Author

Kagalwalla, Amir F., Wechsler, Joshua B., Amsden, Katie, Schwartz, Sally, Makhija, Melanie, Olive, Anthony, Davis, Carla M., Manuel-Rubio, Maria, Marcus, Seth, Shaykin, Ronda, Sulkowski, Maureen, Johnson, Kristen, Ross, Jessica N., Riffle, Mary Ellen, Groetch, Marion, Melin-Aldana, Hector, Schady, Deborah, Palac, Hannah, Kim, Kwan-Youn A., Wershil, Barry K., Collins, Margaret H., and Chehade, Mirna

Published
2017
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37. Ascending to New Heights for Novel Therapeutics for Eosinophilic Esophagitis

Author

Straumann, Alex, Schoepfer, Alain, Chang, Joy W., Peterson, Kathryn, Talley, Nicholas J., Biedermann, Luc, von Arnim, Ulrike, Savarino, Edoardo Vincenzo, Schlag, Christoph, Wershil, Barry K., Menard-Katcher, Calies, Muir, Amanda B., Wechsler, Joshua B., Chehade, Mirna, Spergel, Jonathan M., Atkins, Dan, Oliva, Salvatore, Collins, Margaret, Arva, Nicoleta C., Yang, Guang-Yu, Jensen, Elizabeth T., Safroneeva, Ekaterina, Ackerman, Steven, Gupta, Sandeep K., Couras, Lia, Rothenberg, Marc, Katzka, David, Pletneva, Maria, Wright, Benjamin L., Hiremath, Girish, Klion, Amy, Khoury, Paneez, Attwood, Stephen, Bonis, Peter, Aceves, Seema, Larsson, Helen M., Ghisa, Matteo, Miehlke, Stephan, Vanuytsel, Tim, Woodland, Philip, Greuter, Thomas, Kuang, Fei Li, Hirano, Ikuo, Dellon, Evan S., Falk, Gary W., Gonsalves, Nirmala P., Furuta, Glenn T., and Bredenoord, Albert J.

Published
2024
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39. Bulk T‐Cell Receptor Sequencing Confirms Clonality in Pediatric EoE and Identifies a Food‐Specific Repertoire

Author

Janarthanam, Rethavathi, primary, Kuang, Fei Li, additional, Zalewski, Angelika, additional, Amsden, Katie, additional, Wang, Ming‐Yu, additional, Ostilla, Lorena, additional, Keeley, Kaitlyn, additional, Hirano, Ikuo, additional, Kagalwalla, Amir, additional, Wershil, Barry K., additional, Gonsalves, Nirmala, additional, and Wechsler, Joshua B., additional

Published
2023
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42. Development of a Practical Guide to Implement and Monitor Diet Therapy for Eosinophilic Esophagitis

Author

Chang, Joy W., primary, Kliewer, Kara, additional, Haller, Emily, additional, Lynett, Amanda, additional, Doerfler, Bethany, additional, Katzka, David A., additional, Peterson, Kathryn A., additional, Dellon, Evan S., additional, Gonsalves, Nirmala, additional, Aceves, Seema S., additional, Abonia, Pablo, additional, Atkins, Dan, additional, Bonis, Peter A., additional, Chehade, Mirna, additional, Falk, Gary W., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Kagalwalla, Amir F., additional, Kodroff, Ellyn, additional, Kyle, Scholeigh, additional, Leung, John, additional, Menard-Katcher, Paul, additional, Mir, Sabina, additional, Mukkada, Vincent A., additional, Pesek, Robert, additional, Rothenberg, Marc E., additional, Spergel, Jonathan M., additional, Strobel, Mary Jo, additional, and Wechsler, Joshua B., additional

Published
2023
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44. Bulk T‐cell receptor sequencing confirms clonality in pediatric eosinophilic esophagitis and identifies a food‐specific repertoire.

Author

Janarthanam, Rethavathi, Kuang, Fei Li, Zalewski, Angelika, Amsden, Katie, Wang, Ming‐Yu, Ostilla, Lorena, Keeley, Kaitlyn, Hirano, Ikuo, Kagalwalla, Amir, Wershil, Barry K., Gonsalves, Nirmala, and Wechsler, Joshua B.

Subjects
EOSINOPHILIC esophagitis, T cells, ELIMINATION diets, THERAPEUTICS, ELEMENTAL diet
Abstract

Background: Eosinophilic esophagitis (EoE) involves a chronic immune‐mediated response to dietary antigens. Recent work identifies T‐cell clonality in children with EoE, however, it is unknown whether this is true in adults or whether there is a restricted food‐specific T‐cell repertoire. We sought to confirm T‐cell receptor (TCR) clonality in EoE and assess for differences with specific food triggers. Methods: Bulk TCR sequencing was performed on mRNA isolated from esophageal biopsies obtained from adults and children with EoE (n = 15) who had food triggers confirmed by endoscopic evaluation. Non‐EoE adult and pediatric controls (n = 10) were included. Differences in TCR clonality by disease and treatment status were assessed. Shared and similar V‐J‐CDR3s were assessed based on specific food triggers. Results: Active EoE biopsies from children but not adults displayed decreased unique TCRα/β clonotypes and increased relative abundance of TCRs comprising >1% of the total compared to non‐EoE controls and paired inactive EoE samples. Among patients in which baseline, post diet elimination, and food trigger reintroduction samples (n = 6) were obtained, we observed ~1% of TCRs were shared only between pre‐diet elimination and trigger reintroduction. Patients with a shared EoE trigger (milk) had a greater degree of shared and similar TCRs compared to patients with differing triggers (seafood, wheat, egg, soy). Conclusion: We confirmed relative clonality in children but not adults with active EoE and identified potential food‐specific TCRs, particularly for milk‐triggered EoE. Further studies are needed to better identify the broad TCR repertoire relevant to food triggers. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Enhancing diversity, equity, inclusion, and accessibility in eosinophilic gastrointestinal disease research: the consortium for eosinophilic gastrointestinal disease researchers’ journey

Author

Chehade, Mirna, primary, Furuta, Glenn, additional, Klion, Amy, additional, Abonia, J Pablo, additional, Aceves, Seema, additional, Bose, Paroma, additional, Collins, Margaret H., additional, Davis, Carla, additional, Dellon, Evan S., additional, Eickel, Grant, additional, Falk, Gary, additional, Gupta, Sandeep, additional, Hiremath, Girish, additional, Howard, Amari, additional, Jensen, Elizabeth T., additional, Kesh, Susamita, additional, Khoury, Paneez, additional, Kocher, Kendra, additional, Kodroff, Ellyn, additional, Kyle, Shay, additional, Mak, NaDea, additional, McCoy, Dawn, additional, Mehta, Pooja, additional, Menard-Katcher, Paul, additional, Mukkada, Vincent, additional, Paliana, Ally, additional, Rothenberg, Marc, additional, Sable, Kathleen, additional, Schmitt, Cara, additional, Scott, Melissa, additional, Spergel, Jonathan, additional, Strobel, Mary Jo, additional, Wechsler, Joshua B., additional, Yang, Guang-Yu, additional, Zicarelli, Amy, additional, Muir, Amanda B., additional, Wright, Benjamin L., additional, and Bailey, Dominique D., additional

Published
2023
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47. Mucosal microbiota associated with eosinophilic esophagitis and eosinophilic gastritis

Author

Furuta, Glenn T., primary, Fillon, Sophie A., additional, Williamson, Kayla M., additional, Robertson, Charles E., additional, Stevens, Mark J., additional, Aceves, Seema S., additional, Arva, Nicoleta C., additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Davis, Carla M., additional, Dellon, Evan S., additional, Falk, Gary W., additional, Gonsalves, Nirmala, additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Khoury, Paneez, additional, Leung, John, additional, Martin, Lisa J., additional, Menard-Katcher, Paul, additional, Mukkada, Vincent A., additional, Peterson, Kathryn, additional, Spergel, Jonathan M., additional, Wechsler, Joshua B., additional, Yang, Guang-Yu, additional, Rothenberg, Marc E., additional, and Harris, J. Kirk, additional

Published
2022
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50. Reliability and responsiveness of endoscopic disease activity assessment in eosinophilic esophagitis

Author

Ma, Christopher, primary, Bredenoord, Albert J., additional, Dellon, Evan S., additional, Alexander, Jeffrey A., additional, Biedermann, Luc, additional, Hogan, Malcolm, additional, Guizzetti, Leonardo, additional, Zou, Guangyong, additional, Katzka, David A., additional, Chehade, Mirna, additional, Falk, Gary W., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Kagalwalla, Amir F., additional, Schoepfer, Alain M., additional, Miehlke, Stephan, additional, Moawad, Fouad J., additional, Peterson, Kathryn, additional, Gonsalves, Nirmala P., additional, Straumann, Alex, additional, Wechsler, Joshua B., additional, Rémillard, Julie, additional, Shackelton, Lisa M., additional, Almonte, Hector S., additional, Feagan, Brian G., additional, Jairath, Vipul, additional, and Hirano, Ikuo, additional

Published
2022
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