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310 results on '"Webers, Carroll A.B."'

8. Understanding the clinical and molecular basis of thyroid orbitopathy:a review of recent evidence

Author

Nivean, Pratheeba Devi, Madhivanan, Nivean, Kumaramanikavel, Govindasamy, Berendschot, Tos T.J.M., Webers, Carroll A.B., Paridaens, Dion, Nivean, Pratheeba Devi, Madhivanan, Nivean, Kumaramanikavel, Govindasamy, Berendschot, Tos T.J.M., Webers, Carroll A.B., and Paridaens, Dion

Abstract

Thyroid eye disease (TED) is an autoimmune orbital inflammatory disease which ranges from mild to severe. Tissue remodeling, fibrosis and fat proliferation cause changes in the orbital tissues which can affect esthetics and visual function. In its severe form, it is sight threatening, debilitating, and disfiguring and may lead to social stigma, the embarrassment about which has an impact on the quality of life of those affected and the family members. The pathogenesis of TED, which is influenced by genetic, immunological, and environmental factors, is complex and not fully elucidated. However, it remains unknown what factors determine the severity of the disease. Recent research has revealed a number of diagnostic and prognostic biomarkers of this disease. In this overview of TED, we focus on new insights and perspectives regarding biological agents that may provide a basis for new treatment modalities.

Published
2024

11. Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening.

Author

Agarwal, Aniruddha, Corvi, Federico, Kumar Menia, Nitin, Aggarwal, Kanika, Erckens, Roel J., Berendschot, Tos T.J.M., Webers, Carroll A.B., Invernizzi, Alessandro, Gupta, Vishali, and Sadda, SriniVas

Subjects
OPTICAL coherence tomography, INDOCYANINE green, ANGIOGRAPHY, TOMOGRAPHY, UVEITIS
Abstract

The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC). In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW). Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3% on OCTA in eyes without PW and 35.4 ± 5.0% on SS-OCTA with PW (p =.77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9% and 28.0 ± 4.2% (p <.001) without PW, respectively, and increased to 42.9 ± 4.4% and 48.8 ± 4.1% (p <.001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p <.001). Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Microvascular Dysfunction and Whole‐Brain White Matter Connectivity: The Maastricht Study

Author

Beran, Magdalena, primary, van Gennip, April C.E., additional, Stehouwer, Coen D.A., additional, Jansen, Jacobus F.A., additional, Gupta, Monideepa D., additional, Houben, Alfons J.H.M., additional, Berendschot, Tos T.J.M., additional, Webers, Carroll A.B., additional, Wesselius, Anke, additional, Schalkwijk, Casper G., additional, Backes, Walter H., additional, de Jong, Joost J.A., additional, van der Kallen, Carla J.H., additional, van Greevenbroek, Marleen M.J., additional, Köhler, Sebastian, additional, Vonk, Jet M.J., additional, Geerlings, Mirjam I., additional, Schram, Miranda T., additional, and van Sloten, Thomas T., additional

Published
2024
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15. Biomarkers of microvascular dysfunction and cerebral white matter connectivity: The Maastricht Study

Author

Beran, Magdalena, primary, van Gennip, April C.E., additional, Stehouwer, Coen D.A., additional, Jansen, Jacobus F.A., additional, Gupta, Monideepa D., additional, Houben, Alfons J.H.M., additional, Berendschot, Tos T.J.M., additional, Webers, Carroll A.B., additional, Wesselius, Anke, additional, Schalkwijk, Casper, additional, Backes, Walter H., additional, de Jong, Joost J., additional, van der Kallen, Carla J.H., additional, van Greevenbroek, Marleen M.J., additional, Köhler, Sebastian, additional, Vonk, Jet M.J., additional, Geerlings, Mirjam I., additional, Schram, Miranda T., additional, and van Sloten, Thomas T., additional

Published
2023
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16. Tear biomarkers for Alzheimer’s disease screening and diagnosis (The TearAD study): design and rationale of an observational longitudinal multicenter study

Author

van de Sande, Nienke, primary, Ramakers, Inez H.G.B., additional, Visser, Pieter Jelle, additional, Verhey, Frans R.J., additional, Verbraak, Frank D., additional, Bouwman, Femke H., additional, Berendschot, Tos T.J.M., additional, Nuijts, Rudy M.M.A., additional, Webers, Carroll A.B., additional, and Gijs, Marlies, additional

Published
2023
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21. Tear biomarkers for Alzheimer’s disease screening and diagnosis (The TearAD study): design and rationale of an observational longitudinal multicenter study

Author

de Sande, Nienke van, primary, Ramakers, Inez H.G.B., additional, Visser, Pieter Jelle, additional, Verhey, Frans R.J., additional, Verbraak, Frank D., additional, Bouwman, Femke H., additional, Berendschot, Tos T.J.M., additional, Nuijts, Rudy M.M.A., additional, Webers, Carroll A.B., additional, and Gijs, Marlies, additional

Published
2023
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24. Retinal Functional and Structural Neural Indices: Potential Biomarkers for the Monitoring of Cerebral Neurodegeneration: The Maastricht Study

Author

van der Heide, Frank C.T., primary, Mokhtar, Sara, additional, Khanna, Anjani, additional, Said, Mozhda, additional, Henry, Ronald M.A., additional, Kroon, Abraham A., additional, Dagnelie, Pieter C., additional, Eussen, Simone J.P.M., additional, Berendschot, Tos T.J.M., additional, Schouten, Jan S.A.G., additional, Schram, Miranda T., additional, van der Kallen, Carla J.H., additional, van Greevenbroek, Marleen M.J., additional, Wesselius, Anke, additional, Savelberg, Hans H.C.M., additional, Schaper, Nicolaas C., additional, Webers, Carroll A.B., additional, and Stehouwer, Coen D.A., additional

Published
2023
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25. Quantitative Analysis of the Choroidal Vascularity in Eyes with Uveitis Using Optical Coherence Tomography Angiography: A Systematic Review.

Author

Agarwal, Aniruddha, Singh, Rohan Bir, Erckens, Roel J., Berendschot, Tos T.J.M., and Webers, Carroll A.B.

Subjects
OPTICAL coherence tomography, CHOROID, UVEITIS, ANGIOGRAPHY, INDOCYANINE green
Abstract

The purpose of this systematic review is to identify techniques used for quantification of choriocapillaris (CC) flow in eyes with uveitis using optical coherence tomography angiography (OCTA), report reliability and level of correlation with techniques such as indocyanine green angiography (ICGA). A systematic search of several databases was done. The studies were analyzed for techniques of measurement, reliability, and correlation with other modalities. Risk of bias assessment was performed. Thirteen studies were included. CC vessel density (7 studies) and flow deficit area (4 studies) were the most used indices. There was significant heterogeneity in the studies due to differences in the scan protocol, thresholding strategy, and analysis. Comparison with ICGA was performed by only one study, and reliability indices were reported by only two studies. OCTA is a useful tool to measure the CC vascularity in eyes with uveitis. However, standardized acquisition and analysis protocols are needed. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Association of Markers of Microvascular Dysfunction With Prevalent and Incident Depressive Symptoms: The Maastricht Study

Author

Geraets, Anouk F.J., van Agtmaal, Marnix J.M., Stehouwer, Coen D.A., Sörensen, Ben M., Berendschot, Tos T.J.M., Webers, Carroll A.B., Schaper, Nicolaas C., Henry, Ronald M.A., van der Kallen, Carla J.H., Eussen, Simone J.P.M., Koster, Annemarie, van Sloten, Thomas T., Köhler, Sebastian, Schram, Miranda T., and Houben, Alfons J.H.M.

Published
2020
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28. Blood pressure variability and microvascular dysfunction: the Maastricht Study

Author

Zhou, Tan Lai, Rensma, Sytze P., van der Heide, Frank C.T., Henry, Ronald M.A., Kroon, Abraham A., Houben, Alfons J.H.M., Jansen, Jacobus F.A., Backes, Walter H., Berendschot, Tos T.J.M., Schouten, Jan S.A.G., van Dongen, Martien C.J.M., Eussen, Simone J.P.M., Dagnelie, Pieter C., Webers, Carroll A.B., Schram, Miranda T., Schalkwijk, Casper G., van Sloten, Thomas T., and Stehouwer, Coen D.A.

Published
2020
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41. Effect of combined water drinking test and dark room provocative testing in Caucasian eyes with narrow angles

Author

Römkens, Hellen C.S., Beckers, Henny J.M., Schouten, Jan S.A.G., Berendschot, Tos T.J.M., Webers, Carroll A.B., Römkens, Hellen C.S., Beckers, Henny J.M., Schouten, Jan S.A.G., Berendschot, Tos T.J.M., and Webers, Carroll A.B.

Abstract

Purpose: To assess the usefulness of water drinking test and dark room provocative testing (WDT + DRPT) in current clinical practice by evaluating input parameters from Swept-source Optical Coherence Tomography (SS-OCT) images, and to determine if clinical factors like axial length, central endothelial cell count (CECC) and retinal nerve fibre layer thickness (RNFL) thickness are associated with a positive WDT + DRPT. Methods: SS-OCT examination was performed in consecutive subjects presenting as new patients in the outpatient clinic aged > 40 years. If at least one eye met the inclusion criteria (anterior chamber angles <20° and anterior chamber depth < 2.5 mm on SS-OCT), subjects were included in this study and WDT + DRPT was carried out. The eye with the smallest angle was analysed. The difference in parameters between eyes with a positive (≥8 mmHg) and negative (<8 mmHg) increase in intraocular pressure (IOP) after WDT + DRPT were statistically analysed. Second, the correlation between IOP increase after WDT + DRPT and anterior chamber angle parameters (RNFL thickness, CECC and axial length) was studied. Results: A total of 95 subjects with a mean age of 64 years were included. There was an association between IOP increase after WDT + DRPT and anterior chamber angle characteristics, however this was not of clinical significance. No positive results after WDT + DRPT were found in patients with anterior chamber angles ≥ 20°. Conclusions: The present findings indicate that this combined provocative test has no definite correlative or predictive value in angle closure disease. Further, the test is not useful in predicting early diagnosis or possible CECC or RNFL loss.

Published
2022

43. A systematically derived overview of the non-ubiquitous pathways and genes that define the molecular and genetic signature of the healthy trabecular meshwork

Author

Liesenborghs, Ilona, primary, Schouten, Johannes S.A.G., additional, Kutmon, Martina, additional, Gorgels, Theo G.M.F., additional, Evelo, Chris T., additional, Hubens, Wouter H.G., additional, Beckers, Henny J.M., additional, Webers, Carroll A.B., additional, and Eijssen, Lars M.T., additional

Published
2022
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48. Reply

Author

Beckers, Henny J.M., primary, Aptel, Florent, additional, Webers, Carroll A.B., additional, Bluwol, Elisa, additional, Martínez-de-la-Casa, José M., additional, García-Feijoó, Julián, additional, Lachkar, Yves, additional, Méndez-Hernández, Carmen D., additional, Riss, Isabelle, additional, Shao, Hui, additional, Pinchuk, Leonard, additional, Angeles, Raymund, additional, Sadruddin, Omar, additional, and Shaarawy, Tarek M., additional

Published
2021
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49. Safety and Effectiveness of the PRESERFLO® MicroShunt in Primary Open-Angle Glaucoma: Results from a 2-Year Multicenter Study

Author

Beckers, Henny J.M., Aptel, Florent, Webers, Carroll A.B., Angeles, Raymund, Bluwol, Elisa, Martínez de la Casa, Jose Maria, García Feijoo, Julián, Lachkar, Yves, Méndez Hernández, Carmen Dora, Riss, Isabelle, Shao, Hui, Pinchuk, Leonard, Sadruddin, Omar, Shaarawy, Tarek M., RS: MHeNs - R3 - Neuroscience, MUMC+: MA UECM Oogartsen MUMC (9), Oogheelkunde, MUMC+: MA UECM AIOS (9), MUMC+: *MA Oogheelkunde (3), and MUMC+: University Eye Center Maastricht (3)

Subjects
Clinical trial, genetic structures, Cirugía, MIGS, SIBS, Oftalmología, Óptica oftálmica, Primary open angle glaucoma, eye diseases, Glaucoma filtration surgery, ddc:616.8
Abstract

PURPOSE: To assess the safety and effectiveness of the PRESERFLO® MicroShunt (formerly InnFocus MicroShunt) in patients with primary open-angle glaucoma (POAG). DESIGN: The MicroShunt, a controlled ab externo glaucoma filtration surgery device, was investigated in a 2-year, multicenter, single-arm study. PARTICIPANTS: Eligible patients were aged 18-85 years with POAG inadequately controlled on maximal tolerated medical therapy with intraocular pressure (IOP) ≥18 and ≤35 mmHg or when glaucoma progression warranted surgery. METHODS: The MicroShunt was implanted as a stand-alone procedure with adjunctive use of topical mitomycin C (MMC; 0.2-0.4 mg/ml) for 2-3 minutes. MAIN OUTCOME MEASURES: The primary effectiveness outcome was IOP reduction and success (not requiring reoperation or pressure failures [IOP > 21 mmHg and < 20% reduction in IOP]) at year 1. Additional end points at year 2 included IOP reduction, success, glaucoma medications, adverse events (AEs), and reoperations. Results are reported in the overall population and subgroups of patients receiving 0.2 or 0.4 mg/ml MMC. RESULTS: In 81 patients, mean (± standard deviation [SD]) IOP decreased from 21.7 ± 3.4 mmHg at baseline to 14.5 ± 4.6 mmHg at year 1 and 14.1 ± 3.2 mmHg at year 2 (P < 0.0001). Overall success (with and without supplemental glaucoma medication use) at year 1 was 74.1%. Mean (± SD) number of medications decreased from 2.1 ± 1.3 at baseline to 0.5 ± 0.9 at year 2 (P < 0.0001), and 73.8% of patients were medication free. Most common nonserious AEs were increased IOP requiring medication or selective laser trabeculoplasty (25.9%) and mild-to-moderate keratitis (11.1%). There were 6 (7.4%) reoperations and 5 (6.2%) needlings by year 2. In an analysis (post hoc) according to MMC concentration, overall success was 78.1% (0.2 mg/ml) and 74.4% (0.4 mg/ml; P = 0.710). In the 0.2 and 0.4 mg/ml MMC groups, 51.9% and 90.3% of patients were medication free, respectively (P = 0.001). There was a trend toward lower IOP and higher medication reduction in the 0.4 mg/ml MMC subgroup. CONCLUSIONS: In this study, mean IOP and glaucoma medication reductions were significant and sustained over 2 years postsurgery. No long-term, sight-threatening AEs were reported. Further studies may confirm potential risk/benefits of higher MMC concentration.

Published
2021

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