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1. Greater exposure to PM2.5 and PM10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study

Author

Mokhtar, Sara B. A., Viljoen, Jessica, van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Albers, Jeroen D., Soeterboek, Jens, Scarpa, Fabio, Colonna, Alessia, van der Heide, Frank C. T., van Greevenbroek, Marleen M. J., Bosm, Hans, Kroon, Abraham A., Nuijts, Rudy M. M. A., Gijs, Marlies, Lakerveld, Jeroen, Malik, Rayaz A., Webers, Carroll A. B., Stehouwer, Coen D. A., and Koster, Annemarie

Published
2024
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5. (Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study

Author

Mokhtar, Sara B. A., van der Heide, Frank C. T., Oyaert, Karel A. M., van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Scarpa, Fabio, Colonna, Alessia, de Galan, Bastiaan E., van Greevenbroek, Marleen M. J., Dagnelie, Pieter C., Schalkwijk, Casper G., Nuijts, Rudy M. M. A., Schaper, Nicolaas C., Kroon, Abraham A., Schram, Miranda T., Webers, Carroll A. B., and Stehouwer, Coen D. A.

Published
2023
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8. Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study

Author

van der Heide, Frank C. T., Eussen, Simone J. P. M., Houben, Alfons J. H. M., Henry, Ronald M. A., Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Koster, Annemarie, Jansen, Jacobus F. A., Backes, Walter H., Beulens, Joline W. J., and Stehouwer, Coen D. A.

Published
2023
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10. (Pre)diabetes, glycemia, and daily glucose variability are associated with retinal nerve fiber layer thickness in The Maastricht Study

Author

van der Heide, Frank C. T., Foreman, Yuri D., Franken, Iris W. M., Henry, Ronald M. A., Kroon, Abraham A., Dagnelie, Pieter C., Eussen, Simone J. P. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., Schram, Miranda T., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Schaper, Nicolaas C., Brouwers, Martijn C. G. J., and Stehouwer, Coen D. A.

Published
2022
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11. Greater exposure to PM2.5 and PM10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study.

Author

Mokhtar, Sara B. A., Viljoen, Jessica, van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Albers, Jeroen D., Soeterboek, Jens, Scarpa, Fabio, Colonna, Alessia, van der Heide, Frank C. T., van Greevenbroek, Marleen M. J., Bosm, Hans, Kroon, Abraham A., Nuijts, Rudy M. M. A., Gijs, Marlies, Lakerveld, Jeroen, Malik, Rayaz A., Webers, Carroll A. B., Stehouwer, Coen D. A., and Koster, Annemarie

Subjects
AIR pollutants, TYPE 2 diabetes, PARTICULATE matter, FRACTAL dimensions, AIR pollution
Abstract

Background: Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy. Methods: We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.3 years, 51.6% were women, and 19.9% had type 2 diabetes) living in the Maastricht area. Using the Geoscience and hEalth Cohort COnsortium (GECCO) data we linked the yearly average exposure levels of ambient air pollutants at home address-level [particulate matter with diameters of ≤ 2.5 µm (PM2.5), and ≤ 10.0 µm (PM10), nitrogen dioxide (NO2), and elemental carbon (EC)]. We used linear regression analysis to study the associations between Z-score for ambient air pollutants concentrations (PM2.5, PM10, NO2, and EC) and Z-score for individual corneal nerve measures (corneal nerve bifurcation density, corneal nerve density, corneal nerve length, and fractal dimension). Results: After adjustment for potential confounders (age, sex, level of education, glucose metabolism status, corneal confocal microscopy lag time, inclusion year of participants, smoking status, and alcohol consumption), higher Z-scores for PM2.5 and PM10 were associated with lower Z-scores for corneal nerve bifurcation density, nerve density, nerve length, and nerve fractal dimension [stβ (95% CI): PM2.5 -0.10 (-0.14; -0.05), -0.04 (-0.09; 0.01), -0.11 (-0.16; -0.06), -0.20 (-0.24; -0.15); and PM10 -0.08 (-0.13; -0.03), -0.04 (-0.09; 0.01), -0.08 (-0.13; -0.04), -0.17 (-0.21; -0.12)], respectively. No associations were found between NO2 and EC and corneal nerve measures. Conclusions: Our population-based study demonstrated that exposure to higher levels of PM2.5 and PM10 are associated with higher levels of corneal neurodegeneration, estimated from lower corneal nerve measures. Our results suggest that air pollution may be a determinant for neurodegeneration assessed in the cornea and may impact the ocular surface health as well. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study

Author

van Gennip, April C. E., primary, Gupta, Monideepa D., additional, Houben, Alfons J. H. M., additional, Berendschot, Tos T. J. M., additional, Webers, Carroll A. B., additional, van Greevenbroek, Marleen M. J., additional, van der Kallen, Carla J. H., additional, Koster, Annemarie, additional, Wesselius, Anke, additional, Eussen, Simone J. P. M., additional, Schalkwijk, Casper G., additional, de Galan, Bastiaan E., additional, Köhler, Sebastian, additional, Schram, Miranda T., additional, Stehouwer, Coen D. A., additional, and van Sloten, Thomas T., additional

Published
2024
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14. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure-The Maastricht Study

Author

MS Interne Geneeskunde, Circulatory Health, van der Heide, Frank C T, Steens, Indra L M, Limmen, Betsie, Mokhtar, Sara, van Boxtel, Martin P J, Schram, Miranda T, Köhler, Sebastian, Kroon, Abraham A, van der Kallen, Carla J H, Dagnelie, Pieter C, van Dongen, Martien C J M, Eussen, Simone J P M, Berendschot, Tos T J M, Webers, Carroll A B, van Greevenbroek, Marleen M J, Koster, Annemarie, van Sloten, Thomas T, Jansen, Jacobus F A, Backes, Walter H, Stehouwer, Coen D A, MS Interne Geneeskunde, Circulatory Health, van der Heide, Frank C T, Steens, Indra L M, Limmen, Betsie, Mokhtar, Sara, van Boxtel, Martin P J, Schram, Miranda T, Köhler, Sebastian, Kroon, Abraham A, van der Kallen, Carla J H, Dagnelie, Pieter C, van Dongen, Martien C J M, Eussen, Simone J P M, Berendschot, Tos T J M, Webers, Carroll A B, van Greevenbroek, Marleen M J, Koster, Annemarie, van Sloten, Thomas T, Jansen, Jacobus F A, Backes, Walter H, and Stehouwer, Coen D A

Published
2024

15. Microvascular Dysfunction and Whole-Brain White Matter Connectivity: The Maastricht Study

Author

Cardiovasculaire Epi Team 7a, Circulatory Health, Cardiovasculaire Epi Team 5, Brain, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Beran, Magdalena, van Gennip, April C E, Stehouwer, Coen D A, Jansen, Jacobus F A, Gupta, Monideepa D, Houben, Alfons J H M, Berendschot, Tos T J M, Webers, Carroll A B, Wesselius, Anke, Schalkwijk, Casper G, Backes, Walter H, de Jong, Joost J A, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Köhler, Sebastian, Vonk, Jet M J, Geerlings, Mirjam I, Schram, Miranda T, van Sloten, Thomas T, Cardiovasculaire Epi Team 7a, Circulatory Health, Cardiovasculaire Epi Team 5, Brain, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Beran, Magdalena, van Gennip, April C E, Stehouwer, Coen D A, Jansen, Jacobus F A, Gupta, Monideepa D, Houben, Alfons J H M, Berendschot, Tos T J M, Webers, Carroll A B, Wesselius, Anke, Schalkwijk, Casper G, Backes, Walter H, de Jong, Joost J A, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Köhler, Sebastian, Vonk, Jet M J, Geerlings, Mirjam I, Schram, Miranda T, and van Sloten, Thomas T

Published
2024

17. Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study.

Author

Gennip, April C. E. van, Gupta, Monideepa D., Houben, Alfons J. H. M., Berendschot, Tos T. J. M., Webers, Carroll A. B., Greevenbroek, Marleen M. J. van, Kallen, Carla J. H. van der, Koster, Annemarie, Wesselius, Anke, Eussen, Simone J. P. M., Schalkwijk, Casper G., Galan, Bastiaan E. de, Köhler, Sebastian, Schram, Miranda T., Stehouwer, Coen D. A., and Sloten, Thomas T. van

Subjects
MENTAL depression risk factors, RISK assessment, RESEARCH funding, SECONDARY analysis, BLOOD vessels, BRAIN, REFLEXES, QUESTIONNAIRES, DESCRIPTIVE statistics, ODDS ratio, RETINA, CEREBRAL circulation, CONFIDENCE intervals, MENTAL depression
Abstract

Background Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular function, a proxy for microvascular function in the brain, with incidence and trajectories of clinically relevant depressive symptoms. Methods Longitudinal data are from The Maastricht Study of 5952 participants (59.9 ± 8.5 years/49.7% women) without clinically relevant depressive symptoms at baseline (2010–2017). Central retinal arteriolar equivalent and central retinal venular equivalent (CRAE and CRVE) and a composite score of flicker light-induced retinal arteriolar and venular dilation were assessed at baseline. We assessed incidence and trajectories of clinically relevant depressive symptoms (9-item Patient Health Questionnaire score ⩾10). Trajectories included continuously low prevalence (low, n = 5225 [87.8%]); early increasing, then chronic high prevalence (early-chronic, n = 157 [2.6%]); low, then increasing prevalence (late-increasing, n = 247 [4.2%]); and remitting prevalence (remitting, n = 323 [5.4%]). Results After a median follow-up of 7.0 years (range 1.0–11.0), 806 (13.5%) individuals had incident clinically relevant depressive symptoms. After full adjustment, a larger CRAE and CRVE were each associated with a lower risk of clinically relevant depressive symptoms (hazard ratios [HRs] per standard deviation [ s.d. ]: 0.89 [95% confidence interval (CI) 0.83–0.96] and 0.93 [0.86–0.99], respectively), while a lower flicker light-induced retinal dilation was associated with a higher risk of clinically relevant depressive symptoms (HR per s.d. : 1.10 [1.01–1.20]). Compared to the low trajectory, a larger CRAE was associated with lower odds of belonging to the early-chronic trajectory (OR: 0.83 [0.69–0.99]) and a lower flicker light-induced retinal dilation was associated with higher odds of belonging to the remitting trajectory (OR: 1.23 [1.07–1.43]). Conclusions These findings support the hypothesis that cerebral microvascular dysfunction contributes to the development of depressive symptoms. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Mitochondrial DNA D-loop variants correlate with a primary open-angle glaucoma subgroup

Author

Vallbona-Garcia, Antoni, primary, Lindsey, Patrick J., additional, Kamps, Rick, additional, Stassen, Alphons P. M., additional, Nguyen, Nhan, additional, van Tienen, Florence H. J., additional, Hamers, Ilse H. J., additional, Hardij, Rianne, additional, van Gisbergen, Marike W., additional, Benedikter, Birke J., additional, de Coo, Irenaeus F. M., additional, Webers, Carroll A. B., additional, Gorgels, Theo G. M. F., additional, and Smeets, Hubert J. M., additional

Published
2024
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22. Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study

Author

de Ritter, Rianneke, Sep, Simone J. S., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., de Jong, Marit, Vos, Rimke C., Bots, Michiel L., Reulen, Jos P. H., Houben, Alfons J. H. M., Webers, Carroll A. B., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Peters, Sanne A. E., and Stehouwer, Coen D. A.

Published
2021
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24. Factors affecting corneal deformation amplitude measured by Corvis ST in eyes with open-angle glaucoma.

Author

Pradhan, Zia S., Sreenivasaiah, Shruthi, Deshmukh, Sujit, Mangala, Lavi, Shroff, Sujani, Devi, Sathi, Webers, Carroll A. B., and Rao, Harsha L.

Subjects
OPEN-angle glaucoma, CORNEA, INTRAOCULAR pressure, EYE examination, GLAUCOMA
Abstract

Purpose: To evaluate the factors affecting corneal deformation amplitude (DA) measured using Corvis ST in eyes with open-angle glaucoma. Methods: This prospective, longitudinal study included 48 eyes with open-angle glaucoma who required additional intraocular pressure (IOP)-lowering drops. All eyes underwent a complete eye examination at baseline, including a Corvis ST, which was repeated 4-8 weeks after the change in therapy. Factors affecting the corneal biomechanics, namely the DA, were determined using mixed effect models. Results: The mean age of the cohort was 65.0 ± 7.9 years. The mean IOP reduced from 23.4 ± 5.4 mmHg to 17.9 ± 5 mmHg after the change in glaucoma treatment (P < 0.001). The DA increased from 0.89 ± 0.16 mm to 1.00 ± 0.13 mm after IOP reduction (P < 0.001). On mixed effect model analysis, IOP (-0.02 ± 0.001, P < 0.001) and corneal pachymetry (-0.0003 ± 0.0001, P = 0.02) affected the change in the DA. Conclusion: IOP and corneal pachymetry affect the DA and must be accounted for when using Corvis ST to evaluate corneal biomechanics in glaucoma. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Retinal Functional and Structural Neural Indices: Potential Biomarkers for the Monitoring of Cerebral Neurodegeneration: The Maastricht Study

Author

van der Heide, Frank C T, Mokhtar, Sara, Khanna, Anjani, Said, Mozhda, Henry, Ronald M A, Kroon, Abraham A, Dagnelie, Pieter C, Eussen, Simone J P M, Berendschot, Tos T J M, Schouten, Jan S A G, Schram, Miranda T, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Wesselius, Anke, Savelberg, Hans H C M, Schaper, Nicolaas C, Webers, Carroll A B, Stehouwer, Coen D A, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Interne Geneeskunde, RS: MHeNs - R3 - Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: HVC Pieken Maastricht Studie (8), RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Nutrition and Movement Sciences, MUMC+: MA Endocrinologie (9), MUMC+: University Eye Center Maastricht (3), MUMC+: *MA Oogheelkunde (3), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), and MUMC+: MA Maag Darm Lever (9)

Subjects
Psychiatry and Mental health, Clinical Psychology, General Neuroscience, General Medicine, Geriatrics and Gerontology
Abstract

BACKGROUND: If retinal indices of neurodegeneration are to be biomarkers for the monitoring of cerebral neurodegeneration, it is important to establish whether potentially modifiable risk factors for dementia are associated with retinal neurodegenerative changes.OBJECTIVE: To study associations of dementia risk factors with retinal sensitivity, an index of retinal neural function, and retinal nerve fiber layer (RNFL) thickness, an index of retinal neural structure.METHODS: We used cross-sectional data from The Maastricht Study (up to 5,666 participants, 50.5% men, mean age 59.7), and investigated associations with regression analyses (adjusted for potential confounders).RESULTS: Most risk factors under study (i.e., hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) were significantly associated with lower retinal sensitivity and lower RNFL thickness.CONCLUSION: Findings of this population-based study support the concept that retinal neural indices may be biomarkers for the monitoring of therapeutic strategies that aim to prevent early-stage cerebral neurodegeneration and, ultimately, dementia.

Published
2023

27. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure—The Maastricht Study

Author

van der Heide, Frank C. T., primary, Steens, Indra L. M., additional, Limmen, Betsie, additional, Mokhtar, Sara, additional, van Boxtel, Martin P. J., additional, Schram, Miranda T., additional, Köhler, Sebastian, additional, Kroon, Abraham A., additional, van der Kallen, Carla J. H., additional, Dagnelie, Pieter C., additional, van Dongen, Martien C. J. M., additional, Eussen, Simone J. P. M., additional, Berendschot, Tos T. J. M., additional, Webers, Carroll A. B., additional, van Greevenbroek, Marleen M. J., additional, Koster, Annemarie, additional, van Sloten, Thomas T., additional, Jansen, Jacobus F. A., additional, Backes, Walter H., additional, and Stehouwer, Coen D. A., additional

Published
2023
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29. Microvascular Dysfunction and Whole-Brain White Matter Connectivity: The Maastricht Study.

Author

Beran, Magdalena, van Gennip, April C. E., Stehouwer, Coen D. A., Jansen, Jacobus F. A., Gupta, Monideepa D., Houben, Alfons J. H. M., Berendschot, Tos T. J. M., Webers, Carroll A. B., Wesselius, Anke, Schalkwijk, Casper G., Backes, Walter H., de Jong, Joost J. A., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Köhler, Sebastian, Vonk, Jet M. J., Geerlings, Mirjam I., Schram, Miranda T., and van Sloten, Thomas T.

Published
2024
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30. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure—The Maastricht Study.

Author

van der Heide, Frank C. T., Steens, Indra L. M., Limmen, Betsie, Mokhtar, Sara, van Boxtel, Martin P. J., Schram, Miranda T., Köhler, Sebastian, Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Eussen, Simone J. P. M., Berendschot, Tos T. J. M., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Koster, Annemarie, van Sloten, Thomas T., Jansen, Jacobus F. A., Backes, Walter H., and Stehouwer, Coen D. A.

Abstract

INTRODUCTION: The retina may provide non‐invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross‐sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study

Author

Maasen, Kim, primary, Eussen, Simone J P M, additional, Dagnelie, Pieter C, additional, Houben, Alfons J H M, additional, Webers, Carroll A B, additional, Schram, Miranda T, additional, Berendschot, Tos T J M, additional, Stehouwer, Coen D A, additional, Opperhuizen, Antoon, additional, van Greevenbroek, Marleen M J, additional, and Schalkwijk, Casper G, additional

Published
2022
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36. Effect of combined water drinking test and dark room provocative testing in Caucasian eyes with narrow angles

Author

Römkens, Hellen C S, Römkens, Hellen C S, Beckers, Henny J M, Schouten, Jan S A G, Berendschot, Tos T J M, Webers, Carroll A B, Römkens, Hellen C S, Römkens, Hellen C S, Beckers, Henny J M, Schouten, Jan S A G, Berendschot, Tos T J M, and Webers, Carroll A B

Abstract

PURPOSE: To assess the usefulness of water drinking test and dark room provocative testing (WDT + DRPT) in current clinical practice by evaluating input parameters from Swept-source Optical Coherence Tomography (SS-OCT) images, and to determine if clinical factors like axial length, central endothelial cell count (CECC) and retinal nerve fibre layer thickness (RNFL) thickness are associated with a positive WDT + DRPT.METHODS: SS-OCT examination was performed in consecutive subjects presenting as new patients in the outpatient clinic aged > 40 years. If at least one eye met the inclusion criteria (anterior chamber angles <20° and anterior chamber depth < 2.5 mm on SS-OCT), subjects were included in this study and WDT + DRPT was carried out. The eye with the smallest angle was analysed. The difference in parameters between eyes with a positive (≥8 mmHg) and negative (<8 mmHg) increase in intraocular pressure (IOP) after WDT + DRPT were statistically analysed. Second, the correlation between IOP increase after WDT + DRPT and anterior chamber angle parameters (RNFL thickness, CECC and axial length) was studied.RESULTS: A total of 95 subjects with a mean age of 64 years were included. There was an association between IOP increase after WDT + DRPT and anterior chamber angle characteristics, however this was not of clinical significance. No positive results after WDT + DRPT were found in patients with anterior chamber angles ≥ 20°.CONCLUSIONS: The present findings indicate that this combined provocative test has no definite correlative or predictive value in angle closure disease. Further, the test is not useful in predicting early diagnosis or possible CECC or RNFL loss.

Published
2022

39. Luminosity rectified blind Richardson-Lucy deconvolution for single retinal image restoration

Author

Zhang, Shuhe, Webers, Carroll A B, Berendschot, Tos T J M, Oogheelkunde, RS: MHeNs - R3 - Neuroscience, MUMC+: University Eye Center Maastricht (3), and RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health

Subjects
History, Polymers and Plastics, Health Informatics, Business and International Management, Industrial and Manufacturing Engineering, Software, Computer Science Applications
Abstract

BACKGROUND AND OBJECTIVE: Due to imperfect imaging conditions, retinal images can be degraded by uneven/insufficient illumination, blurriness caused by optical aberrations and unintentional motions. Degraded images reduce the effectiveness of diagnosis by an ophthalmologist. To restore the image quality, in this research we propose the luminosity rectified Richardson-Lucy (LRRL) blind deconvolution framework for single retinal image restoration.METHODS: We established an image formation model based on the double-pass fundus reflection feature and developed a differentiable non-convex cost function that jointly achieves illumination correction and blind deconvolution. To solve this non-convex optimization problem, we derived the closed-form expression of the gradients and used gradient descent with Nesterov-accelerated adaptive momentum estimation to accelerate the optimization, which is more efficient than the traditional half quadratic splitting method.RESULTS: The LRRL was tested on 1719 images from three public databases. Four image quality matrixes including image definition, image sharpness, image entropy, and image multiscale contrast were used for objective assessments. The LRRL was compared against the state-of-the-art retinal image blind deconvolution methods.CONCLUSIONS: Our LRRL corrects the problematic illumination and improves the clarity of the retinal image simultaneously, showing its superiority in terms of restoration quality and implementation efficiency. The MATLAB code is available on Github.

Published
2023

42. Association of Retinal Nerve Fiber Layer Thickness, an Index of Neurodegeneration, With Depressive Symptoms Over Time

Author

van der Heide, Frank C. T., primary, Steens, Indra L. M., additional, Geraets, Anouk F. J., additional, Foreman, Yuri D., additional, Henry, Ronald M. A., additional, Kroon, Abraham A., additional, van der Kallen, Carla J. H., additional, van Sloten, Thomas T., additional, Dagnelie, Pieter C., additional, van Dongen, Martien C. J. M., additional, Eussen, Simone J. P. M., additional, Berendschot, Tos T. J. M., additional, Schouten, Jan S. A. G., additional, Webers, Carroll A. B., additional, van Greevenbroek, Marleen M. J., additional, Wesselius, Anke, additional, Koster, Annemarie, additional, Schaper, Nicolaas C., additional, Schram, Miranda T., additional, Köhler, Seb, additional, and Stehouwer, Coen D. A., additional

Published
2021
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43. In-Depth Investigation of Conjunctival Swabs and Tear Fluid of Symptomatic COVID-19 Patients, an Observational Cohort Study

Author

Gijs, Marlies, primary, Veugen, Judith M. J., additional, Wolffs, Petra F. G., additional, Savelkoul, Paul H. M., additional, Tas, Jeanette, additional, van Bussel, Bas C. T., additional, de Kruif, Martijn D., additional, Henry, Ronald M. A., additional, Webers, Carroll A. B., additional, Dickman, Mor M., additional, and Nuijts, Rudy M. M. A., additional

Published
2021
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44. A genome-wide association study for corticosteroid-induced increase in eye pressure after using topical corticosteroids

Author

Liesenborghs, Ilona, van Beek, Daan, Berend-Schot, Tos T. J. M., Adriaens, Michiel E., Gorgels, Theo G. M. F., Cornelissen, Michiel F., Beckers, Henny J. M., Webers, Carroll A. B., Ramdas, Wishal D., Nuijts, Rudy M. M. A., Schouten, Johannes S. A. G., Maastricht Centre for Systems Biology, MUMC+: MA UECM AIOS (9), RS: FSE MaCSBio, RS: FPN MaCSBio, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: MHeNs - R3 - Neuroscience, Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), RS: FHML MaCSBio, MUMC+: *AB Onderzoekers (9), MUMC+: *MA Oogheelkunde (3), MUMC+: University Eye Center Maastricht (3), and MUMC+: *AB Refractie Chirurgie Oogheelkunde (9)

Published
2021

46. Additional file 1 of Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study

Author

De Ritter, Rianneke, Sep, Simone J. S., Van Der Kallen, Carla J. H., Van Greevenbroek, Marleen M. J., De Jong, Marit, Rimke C. Vos, Bots, Michiel L., Reulen, Jos P. H., Houben, Alfons J. H. M., Webers, Carroll A. B., Tos T. J. M. Berendschot, Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Peters, Sanne A. E., and Stehouwer, Coen D. A.

Abstract

Additional file 1: Table S1. Differences within and between sexes in mean differences in microvascular complications and retinal measures according to glucose metabolism status. Table S2. Differences within and between sexes in mean differences in microvascular complications and retinal measures according to HbA1c, fasting glucose and 2-h postload glucose (all models). Table S3. Differences between sexes in mean differences in microvascular complications and retinal measures according to glucose metabolism status – with BMI used instead of waist circumference. Table S4. Differences within and between sexes in mean differences in microvascular complications and retinal measures according to glucose metabolism status – premenopausal women excluded. Table S5. Differences within and between sexes in mean differences in neuropathy according to glucose metabolism status – with additional adjustment for metformin use (model 2 and 3).

Published
2021
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47. Association between retinal vascular caliber and brain structure in schizophrenia

Author

Korann, Vittal, Korann, Vittal, Appaji, Abhishek, Jacob, Arpitha, Devi, Priyanka, Nagendra, Bhargavi, Chako, Dona Maria, Padmanabha, Ananth, Thonse, Umesh, Bharath, Rose Dawn, Kumar, Vijay, Varambally, Shivarama, Venkatasubramanian, Ganesan, Rao, Shyam Vasudeva, Webers, Carroll A B, Berendschot, Tos T J M, Rao, Naren P, Korann, Vittal, Korann, Vittal, Appaji, Abhishek, Jacob, Arpitha, Devi, Priyanka, Nagendra, Bhargavi, Chako, Dona Maria, Padmanabha, Ananth, Thonse, Umesh, Bharath, Rose Dawn, Kumar, Vijay, Varambally, Shivarama, Venkatasubramanian, Ganesan, Rao, Shyam Vasudeva, Webers, Carroll A B, Berendschot, Tos T J M, and Rao, Naren P

Abstract

OBJECTIVE: Several lines of research in the last decade have indicated the potential utility of retina as a window to the brain. Emerging evidence suggests abnormalities in retinal vascular caliber in schizophrenia. However, the relationship between retinal vascular measures and brain structure has not been examined in schizophrenia to date. Hence, we examined the relationship between retinal vasculature measured using fundus photography and brain structure measured using magnetic resonance imaging.METHOD: We recruited 17 healthy volunteers and 20 patients with schizophrenia. Using a non-mydriatic camera, we captured the images for left and right eyes separately and retinal vascular calibers were calculated using a semi-automated software package. Whole-brain anatomical T1 MPRAGE images were acquired using a 3-Tesla MRI scanner. Whole-brain and regional volume and cortical thickness were calculated using the Freesurfer software package. We used FreeSurfer's QDEC interface to compute vertex-by-vertex for analysis of the volume and cortical thickness. The relation between brain volume, cortical thickness, and retinal vascular caliber was examined using partial correlation and regression analysis.RESULTS: There was a significant negative correlation between average CRVE and global cortical mean thickness in schizophrenia but not in healthy. In schizophrenia patients, there was a significant negative correlation between average CRVE and cortical thickness in frontal regions - left rostral middle frontal, left superior frontal, and right caudal middle frontal gyri and posterior brain regions - left lateral occipital gyrus and left posterior cingulate cortex.DISCUSSION: The findings of the study suggest potential utility of retinal venular diameter as a proxy marker to abnormal neurodevelopment in schizophrenia.

Published
2021

48. Vascular risk factors for optical coherence tomography-detected macular cysts: The Maastricht Study

Author

De Clerck, Eline E B, De Clerck, Eline E B, Schouten, Jan S A G, Berendschot, Tos T J M, Goezinne, Fleur, Liesenborghs, Ilona, Dagnelie, Pieter C, Schaper, Nicolaas C, Kroon, Abraham A, Henry, Ronald M A, Reesink, Koen D, Schram, Miranda T, Stehouwer, Coen D A, Webers, Carroll A B, De Clerck, Eline E B, De Clerck, Eline E B, Schouten, Jan S A G, Berendschot, Tos T J M, Goezinne, Fleur, Liesenborghs, Ilona, Dagnelie, Pieter C, Schaper, Nicolaas C, Kroon, Abraham A, Henry, Ronald M A, Reesink, Koen D, Schram, Miranda T, Stehouwer, Coen D A, and Webers, Carroll A B

Abstract

PURPOSE: To investigate whether higher blood pressure and greater arterial stiffness are associated with the presence of macular cysts and whether this association is already present in the absence of micro-aneurysms in individuals with and without type 2 diabetes.METHODS: Using spectral domain optical coherence tomography (OCT), we performed a macular volume scan in 2647 individuals (mean age 60 ± 8 years, 50% men, 27% type 2 diabetes). The association between macular cysts and 24-hour systolic and diastolic blood pressure, pulse pressure, mean arterial blood pressure, carotid-femoral pulse wave velocity and carotid distensibility was assessed by use of logistic regression.RESULTS: Twenty-four hours systolic blood pressure was associated with the presence of macular cysts [OR = 1.03 (95% CI 1.00-1.05) per 1 mmHg, p = 0.03]. 24 hr pulse pressure [OR = 1.61 (95% CI 1.11-2.34) per 10 mmHg, p = 0.01] and carotid-femoral pulse wave velocity [OR = 1.16 (95% CI 1.02-1.32) per 1 m/s, p = 0.02] were associated with macular cysts, while carotid distensibility was not [OR = 1.03 (95% CI 0.96-1.11) per 1.0*10-3 /kPa, p = 0.45]. Associations were similar in individuals with and without type 2 diabetes and were already present in the absence of micro-aneurysms.CONCLUSION: Twenty-four hours systolic blood pressure, 24 hr pulse pressure and carotid-femoral pulse wave velocity are associated with the presence of OCT-detected macular cysts in individuals with and without type 2 diabetes, even in the absence of micro-aneurysms. Therefore, blood pressure and aortic stiffness are potential factors contributing to macular cysts.

Published
2021

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