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Karl-Josef Franke,1,2 Ulrike Domanski,1 Maik Schroeder,1 Volker Jansen,3 Frank Artmann,4 Uwe Weber,5 Rainer Ettler,6 Georg Nilius1,2 1Department of Pneumology and Critical Care Medicine, Helios Klinik Ambrock, Hagen, 2Witten/Herdecke University, Witten, 3Lung Practice Jansen, Menden, 4Aeroprax Wuppertal, Wuppertal, 5Lung Practice Witten, Witten, 6Lung Practice Ettler, Hagen, Germany Background: Regular physical activity is associated with reduced mortality in patients with chronic obstructive pulmonary disease (COPD). Interventions to reduce time spent in sedentary behavior could improve outcomes. The primary purpose was to investigate the impact of telemonitoring with supportive phone calls on daily exercise times with newly established home exercise bicycle training. The secondary aim was to examine the potential improvement in health-related quality of life and physical activity compared to baseline. Methods: This prospective crossover-randomized study was performed over 6 months in stable COPD patients. The intervention phase (domiciliary training with supporting telephone calls) and the control phase (training without phone calls) were randomly assigned to the first or the last 3 months. In the intervention phase, patients were called once a week if they did not achieve a real-time monitored daily cycle time of 20 minutes. Secondary aims were evaluated at baseline and after 3 and 6 months. Health-related quality of life was measured by the COPD Assessment Test (CAT), physical activity by the Godin Leisure Time Exercise Questionnaire (GLTEQ). Results: Of the 53 included patients, 44 patients completed the study (forced expiratory volume in 1 second 47.5%±15.8% predicted). In the intervention phase, daily exercise time was significantly higher compared to the control phase (24.2±9.4 versus 19.6±10.3 minutes). Compared to baseline (17.6±6.1), the CAT-score improved in the intervention

Die vorliegende Untersuchung hatte zum Ziel, retrospektiv die Krankengeschichten von 70 Patienten mit chronischen myeloproliferativen Erkrankungen zu analysieren und das klinische Krankheitsbild so weit wie möglich in Beziehung zur Hannover-Klassifikation der CMPE, welche ausschließlich auf der Histopathologie des Knochenmarks beruht, in Beziehung zu setzen. Es konnte gezeigt werden, dass die Hannover-Klassifikation insbesondere hinsichtlich Beschwerdesymptomatik, Milz- und Lebergröße, hämatologischer Befunde sowie ALP-Index auch klinische Relevanz besitzt und dem Hämatologen darüber hinaus wertvolle Hinweise zum Krankheitsbild und ein besseres Verständnis für die biologische Natur der CMPE vermitteln kann., The following study was designed as a retrospective analysis on 70 patients with CMPD and examined the correlation between their clinical presentation and their classification in the "Hannover-classification" system, a system that solely relies on the histopathological examination of the bone marrow. We are able to show that the "Hannover-classification" correlates with the patients complaints and symptoms, size of spleen and liver, ALP-Index as well as laboratory values and therefore not only contains clinically relevant information for the Hematologist but also helps deepen our understanding of the biological course and nature of CMPD's.

Die vorliegende Untersuchung hatte zum Ziel, retrospektiv die Krankengeschichten von 70 Patienten mit chronischen myeloproliferativen Erkrankungen zu analysieren und das klinische Krankheitsbild so weit wie möglich in Beziehung zur Hannover-Klassifikation der CMPE, welche ausschließlich auf der Histopathologie des Knochenmarks beruht, in Beziehung zu setzen. Es konnte gezeigt werden, dass die Hannover-Klassifikation insbesondere hinsichtlich Beschwerdesymptomatik, Milz- und Lebergröße, hämatologischer Befunde sowie ALP-Index auch klinische Relevanz besitzt und dem Hämatologen darüber hinaus wertvolle Hinweise zum Krankheitsbild und ein besseres Verständnis für die biologische Natur der CMPE vermitteln kann., The following study was designed as a retrospective analysis on 70 patients with CMPD and examined the correlation between their clinical presentation and their classification in the "Hannover-classification" system, a system that solely relies on the histopathological examination of the bone marrow. We are able to show that the "Hannover-classification" correlates with the patients complaints and symptoms, size of spleen and liver, ALP-Index as well as laboratory values and therefore not only contains clinically relevant information for the Hematologist but also helps deepen our understanding of the biological course and nature of CMPD's.