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We present a detailed study of the coherence of a tunable capacitively-shunted flux qubit, designed for coherent quantum annealing applications. The measured relaxation at the qubit symmetry point is mainly due to intrinsic flux noise in the main qubit loop for qubit frequencies below $\sim3~\text{GHz}$. At higher frequencies, thermal noise in the bias line makes a significant contribution to the relaxation, arising from the design choice to experimentally explore both fast annealing and high-frequency control. The measured dephasing rate is primarily due to intrinsic low-frequency flux noise in the two qubit loops, with additional contribution from the low-frequency noise of control electronics used for fast annealing. The flux-bias dependence of the dephasing time also reveals apparent noise correlation between the two qubit loops, possibly due to non-local sources of flux noise or junction critical-current noise. Our results are relevant for ongoing efforts toward building superconducting quantum annealers with increased coherence., Comment: 18 pages, 10 figures

Flux tunability is an important engineering resource for superconducting circuits. Large-scale quantum computers based on flux-tunable superconducting circuits face the problem of flux crosstalk, which needs to be accurately calibrated to realize high-fidelity quantum operations. Typical calibration methods either assume that circuit elements can be effectively decoupled and simple models can be applied, or require a large amount of data. Such methods become ineffective as the system size increases and circuit interactions become stronger. Here we propose a new method for calibrating flux crosstalk, which is independent of the underlying circuit model. Using the fundamental property that superconducting circuits respond periodically to external fluxes, crosstalk calibration of N flux channels can be treated as N independent optimization problems, with the objective functions being the periodicity of a measured signal depending on the compensation parameters. We demonstrate this method on a small-scale quantum annealing circuit based on superconducting flux qubits, achieving comparable accuracy with previous methods. We also show that the objective function usually has a nearly convex landscape, allowing efficient optimization.

Landau-Zener (LZ) tunneling, describing transitions in a two-level system during a sweep through an anti-crossing, is a model applicable to a wide range of physical phenomena, such as atomic collisions, chemical reactions, and molecular magnets, and has been extensively studied theoretically and experimentally. Dissipation due to coupling between the system and environment is an important factor in determining the transition rates. Here we report experimental results on the dissipative LZ transition. Using a tunable superconducting flux qubit, we observe for the first time the crossover from weak to strong coupling to the environment. The weak coupling limit corresponds to small system-environment coupling and leads to environment-induced thermalization. In the strong coupling limit, environmental excitations dress the system and transitions occur between the dressed states. Our results confirm previous theoretical studies of dissipative LZ tunneling in the weak and strong coupling limits. Our results for the intermediate regime are novel and could stimulate further theoretical development of open system dynamics. This work provides insight into the role of open system effects on quantum annealing, which employs quantum tunneling to search for low-energy solutions to hard computational problems., Comment: 18 pages, 12 figures

Magnetic flux tunability is an essential feature in most approaches to quantum computing based on superconducting qubits. Independent control of the fluxes in multiple loops is hampered by crosstalk. Calibrating flux crosstalk becomes a challenging task when the circuit elements interact strongly. We present a novel approach to flux crosstalk calibration, which is circuit model independent and relies on an iterative process to gradually improve calibration accuracy. This method allows us to reduce errors due to the inductive coupling between loops. The calibration procedure is automated and implemented on devices consisting of tunable flux qubits and couplers with up to 27 control loops. We devise a method to characterize the calibration error, which is used to show that the errors of the measured crosstalk coefficients are all below 0.17%., Comment: 22 pages, 15 figures

As the field of superconducting quantum computing advances from the few-qubit stage to larger-scale processors, qubit addressability and extensibility will necessitate the use of 3D integration and packaging. While 3D integration is well-developed for commercial electronics, relatively little work has been performed to determine its compatibility with high-coherence solid-state qubits. Of particular concern, qubit coherence times can be suppressed by the requisite processing steps and close proximity of another chip. In this work, we use a flip-chip process to bond a chip with superconducting flux qubits to another chip containing structures for qubit readout and control. We demonstrate that high qubit coherence ($T_1$, $T_{2,\rm{echo}} > 20\,\mu$s) is maintained in a flip-chip geometry in the presence of galvanic, capacitive, and inductive coupling between the chips.

We observe the quantum Zeno effect -- where the act of measurement slows the rate of quantum state transitions -- in a superconducting qubit using linear circuit quantum electrodynamics readout and a near-quantum-limited following amplifier. Under simultaneous strong measurement and qubit drive, the qubit undergoes a series of quantum jumps between states. These jumps are visible in the experimental measurement record and are analyzed using maximum likelihood estimation to determine qubit transition rates. The observed rates agree with both analytical predictions and numerical simulations. The analysis methods are suitable for processing general noisy random telegraph signals., Comment: 15 pages, 8 figures

In this review, we discuss recent experiments that investigate how the quantum sate of a superconducting qubit evolves during measurement. We provide a pedagogical overview of the measurement process, when the qubit is dispersively coupled to a microwave frequency cavity, and the qubit state is encoded in the phase of a microwave tone that probes the cavity. A continuous measurement record is used to reconstruct the individual quantum trajectories of the qubit state, and quantum state tomography is performed to verify that the state has been tracked accurately. Furthermore, we discuss ensembles of trajectories, time-symmetric evolution, two-qubit trajectories, and potential applications in measurement-based quantum error correction.

A central feature of quantum mechanics is that a measurement is intrinsically probabilistic. As a result, continuously monitoring a quantum system will randomly perturb its natural unitary evolution. The ability to control a quantum system in the presence of these fluctuations is of increasing importance in quantum information processing and finds application in fields ranging from nuclear magnetic resonance to chemical synthesis. A detailed understanding of this stochastic evolution is essential for the development of optimized control methods. Here we reconstruct the individual quantum trajectories of a superconducting circuit that evolves in competition between continuous weak measurement and driven unitary evolution. By tracking individual trajectories that evolve between an arbitrary choice of initial and final states we can deduce the most probable path through quantum state space. These pre- and post-selected quantum trajectories also reveal the optimal detector signal in the form of a smooth time-continuous function that connects the desired boundary conditions. Our investigation reveals the rich interplay between measurement dynamics, typically associated with wave function collapse, and unitary evolution of the quantum state as described by the Schrodinger equation. These results and the underlying theory, based on a principle of least action, reveal the optimal route from initial to final states, and may enable new quantum control methods for state steering and information processing., Comment: 12 pages, 9 figures

The length of time that a quantum system can exist in a superposition state is determined by how strongly it interacts with its environment. This interaction entangles the quantum state with the inherent fluctuations of the environment. If these fluctuations are not measured, the environment can be viewed as a source of noise, causing random evolution of the quantum system from an initially pure state into a statistical mixture-a process known as decoherence. However, by accurately measuring the environment in real time, the quantum system can be maintained in a pure state and its time evolution described by a quantum trajectory conditioned on the measurement outcome. We employ weak measurements to monitor a microwave cavity embedding a superconducting qubit and track the individual quantum trajectories of the system. In this architecture, the environment is dominated by the fluctuations of a single electromagnetic mode of the cavity. Using a near-quantum-limited parametric amplifier, we selectively measure either the phase or amplitude of the cavity field, and thereby confine trajectories to either the equator or a meridian of the Bloch sphere. We perform quantum state tomography at discrete times along the trajectory to verify that we have faithfully tracked the state of the quantum system as it diffuses on the surface of the Bloch sphere. Our results demonstrate that decoherence can be mitigated by environmental monitoring and validate the foundations of quantum feedback approaches based on Bayesian statistics. Moreover, our experiments suggest a new route for implementing what Schrodinger termed "quantum steering"-harnessing action at a distance to manipulate quantum states via measurement., Comment: 7 pages, 6 figures

Quantum fluctuations of the electromagnetic vacuum are responsible for physical effects such as the Casimir force and the radiative decay of atoms, and set fundamental limits on the sensitivity of measurements. Entanglement between photons can produce correlations that result in a reduction of these fluctuations below the vacuum level allowing measurements that surpass the standard quantum limit in sensitivity. Here we demonstrate that the radiative decay rate of an atom that is coupled to quadrature squeezed electromagnetic vacuum can be reduced below its natural linewidth. We observe a two-fold reduction of the transverse radiative decay rate of a superconducting artificial atom coupled to continuum squeezed vacuum generated by a Josephson parametric amplifier, allowing the transverse coherence time T_2 to exceed the vacuum decay limit of 2T_1. We demonstrate that the measured radiative decay dynamics can be used to tomographically reconstruct the Wigner distribution of the the itinerant squeezed state. Our results are the first confirmation of a canonical prediction of quantum optics and open the door to new studies of the quantum light-matter interaction., Comment: 9 pages, 5 figures

When a frequency chirped excitation is applied to a classical high-Q nonlinear oscillator, its motion becomes dynamically synchronized to the drive and large oscillation amplitude is observed, provided the drive strength exceeds the critical threshold for autoresonance. We demonstrate that when such an oscillator is strongly coupled to a quantized superconducting qubit, both the effective nonlinearity and the threshold become a non-trivial function of the qubit-oscillator detuning. Moreover, the autoresonant threshold is sensitive to the quantum state of the qubit and may be used to realize a high fidelity, latching readout whose speed is not limited by the oscillator Q., Comment: 5 pages, 4 figures

We demonstrate quantum bath engineering for a superconducting artificial atom coupled to a microwave cavity. By tailoring the spectrum of microwave photon shot noise in the cavity, we create a dissipative environment that autonomously relaxes the atom to an arbitrarily specified coherent superposition of the ground and excited states. In the presence of background thermal excitations, this mechanism increases the state purity and effectively cools the dressed atom state to a low temperature.

We observe measurement-induced qubit state mixing in a transmon qubit dispersively coupled to a planar readout cavity. Our results indicate that dephasing noise at the qubit-readout detuning frequency is up-converted by readout photons to cause spurious qubit state transitions, thus limiting the nondemolition character of the readout. Furthermore, we use the qubit transition rate as a tool to extract an equivalent flux noise spectral density at f ~ 1 GHz and find agreement with values extrapolated from a $1/f^\alpha$ fit to the measured flux noise spectral density below 1 Hz., Comment: 5 pages, 4 figures. Final journal version

The act of measurement bridges the quantum and classical worlds by projecting a superposition of possible states into a single, albeit probabilistic, outcome. The time-scale of this "instantaneous" process can be stretched using weak measurements so that it takes the form of a gradual random walk towards a final state. Remarkably, the interim measurement record is sufficient to continuously track and steer the quantum state using feedback. We monitor the dynamics of a resonantly driven quantum two-level system -- a superconducting quantum bit --using a near-noiseless parametric amplifier. The high-fidelity measurement output is used to actively stabilize the phase of Rabi oscillations, enabling them to persist indefinitely. This new functionality shows promise for fighting decoherence and defines a path for continuous quantum error correction., Comment: Manuscript: 5 Pages and 3 figures ; Supplementary Information: 9 pages and 3 figures

We present measurements of 1/f frequency noise in both linear and Josephson-junction-embedded superconducting aluminum resonators in the low power, low temperature regime - typical operating conditions for superconducting qubits. The addition of the Josephson junction does not result in additional frequency noise, thereby placing an upper limit for fractional critical current fluctuations of $10^{-8}$ (Hz$^{-1/2}$) at 1 Hz for sub-micron, shadow evaporated junctions. These values imply a minimum dephasing time for a superconducting qubit due to critical current noise of 40 -- 1400 $\mu$s depending on qubit architecture. Occasionally, at temperatures above 50 mK, we observe the activation of individual fluctuators which increase the level of noise significantly and exhibit Lorentzian spectra.

PURPOSE: The objective was to investigate the ability of a glycosteroid (TC002) to increase the oral bioavailability of gentamicin. METHODS: Admixtures of gentamicin and TC002 were administered to the rat ileum by injection and to dogs by ileal or jejunal externalized ports, or PO. Bioavailability of gentamicin was determined by HPLC. 3H-TC002 was injected via externalized cannulas into rat ileum or jejunum, or PO and its distribution and elimination was determined. The metabolism of TC002 in rats was evaluated by solid phase extraction and HPLC analysis of plasma, urine and feces following oral or intestinal administration. RESULTS: The bioavailability of gentamicin was substantially increased in the presence of TC002 in both rats and dogs. The level of absorption was dependent on the concentration of TC002 and site of administration. Greatest absorption occurred following ileal orjejunal administration. TC002 was significantly more efficacious than sodium taurocholate, but similar in cytotoxicity. TC002 remained primarily in the GI tract following oral or intestinal administration and cleared rapidly from the body. It was only partly metabolized in the GI tract, but was rapidly and completely converted to its metabolite in plasma and urine. CONCLUSIONS: TC002 shows promise as a new drug transport agent for promoting intestinal absorption of polar molecules such as gentamicin.