3,703 results on '"Weber, Robert"'
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2. A US perspective on closing the carbon cycle to defossilize difficult-to-electrify segments of our economy
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Shaw, Wendy J, Kidder, Michelle K, Bare, Simon R, Delferro, Massimiliano, Morris, James R, Toma, Francesca M, Senanayake, Sanjaya D, Autrey, Tom, Biddinger, Elizabeth J, Boettcher, Shannon, Bowden, Mark E, Britt, Phillip F, Brown, Robert C, Bullock, R Morris, Chen, Jingguang G, Daniel, Claus, Dorhout, Peter K, Efroymson, Rebecca A, Gaffney, Kelly J, Gagliardi, Laura, Harper, Aaron S, Heldebrant, David J, Luca, Oana R, Lyubovsky, Maxim, Male, Jonathan L, Miller, Daniel J, Prozorov, Tanya, Rallo, Robert, Rana, Rachita, Rioux, Robert M, Sadow, Aaron D, Schaidle, Joshua A, Schulte, Lisa A, Tarpeh, William A, Vlachos, Dionisios G, Vogt, Bryan D, Weber, Robert S, Yang, Jenny Y, Arenholz, Elke, Helms, Brett A, Huang, Wenyu, Jordahl, James L, Karakaya, Canan, Kian, Kourosh Cyrus, Kothandaraman, Jotheeswari, Lercher, Johannes, Liu, Ping, Malhotra, Deepika, Mueller, Karl T, O’Brien, Casey P, Palomino, Robert M, Qi, Long, Rodriguez, José A, Rousseau, Roger, Russell, Jake C, Sarazen, Michele L, Sholl, David S, Smith, Emily A, Stevens, Michaela Burke, Surendranath, Yogesh, Tassone, Christopher J, Tran, Ba, Tumas, William, and Walton, Krista S
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Chemical Sciences ,Climate Action ,Responsible Consumption and Production ,Chemical sciences - Abstract
Electrification to reduce or eliminate greenhouse gas emissions is essential to mitigate climate change. However, a substantial portion of our manufacturing and transportation infrastructure will be difficult to electrify and/or will continue to use carbon as a key component, including areas in aviation, heavy-duty and marine transportation, and the chemical industry. In this Roadmap, we explore how multidisciplinary approaches will enable us to close the carbon cycle and create a circular economy by defossilizing these difficult-to-electrify areas and those that will continue to need carbon. We discuss two approaches for this: developing carbon alternatives and improving our ability to reuse carbon, enabled by separations. Furthermore, we posit that co-design and use-driven fundamental science are essential to reach aggressive greenhouse gas reduction targets.
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- 2024
3. Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies
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Mason, James Paul, Werth, Alexandra, West, Colin G., Youngblood, Allison A., Woodraska, Donald L., Peck, Courtney, Lacjak, Kevin, Frick, Florian G., Gabir, Moutamen, Alsinan, Reema A., Jacobsen, Thomas, Alrubaie, Mohammad, Chizmar, Kayla M., Lau, Benjamin P., Dominguez, Lizbeth Montoya, Price, David, Butler, Dylan R., Biron, Connor J., Feoktistov, Nikita, Dewey, Kai, Loomis, N. E., Bodzianowski, Michal, Kuybus, Connor, Dietrick, Henry, Wolfe, Aubrey M., Guerrero, Matt, Vinson, Jessica, Starbuck, Peter, Litton, Shelby D, Beck, M. G., Fisch, Jean-Paul, West, Ayana, Muniz, Alexis A., Chavez, Luis, Upthegrove, Zachary T., Runyon, Brenton M., Salazar, J., Kritzberg, Jake E., Murrel, Tyler, Ho, Ella, LaFemina, Quintin Y., Elbashir, Sara I., Chang, Ethan C., Hudson, Zachary A., Nussbaum, Rosemary O., Kennedy, Kellen, Kim, Kevin, Arango, Camila Villamil, Albakr, Mohammed A., Rotter, Michael, Garscadden, A. J., Salcido-Alcontar JR, Antonio, Pearl, Harrison M., Stepaniak, Tyler, Marquez, Josie A., Marsh, Lauren, Andringa, Jesse C, Osogwin, Austin, Shields, Amanda M., Brookins, Sarah, Hach, Grace K., Clausi, Alexis R., Millican, Emily B., Jaimes, Alan A, Graham, Alaina S., Burritt, John J., Perez, J. S., Ramirez, Nathaniel, Suri, Rohan, Myer, Michael S., Kresek, Zoe M., Goldsberry, C. A., Payne, Genevieve K., Jourabchi, Tara, Hu, J., Lucca, Jeffrey, Feng, Zitian, Gilpatrick, Connor B., Khan, Ibraheem A., Warble, Keenan, Sweeney, Joshua D., Dorricott, Philip, Meyer, Ethan, Kothamdi, Yash S., Sohail, Arman S., Grell, Kristyn, Floyd, Aidan, Bard, Titus, Mathieson, Randi M., Reed, Joseph, Cisneros, Alexis, Payne, Matthew P., Jarriel, J. R., Mora, Jacqueline Rodriguez, Sundell, M. E., Patel, Kajal, Alesmail, Mohammad, Alnasrallah, Yousef A, Abdullah, Jumana T., Molina-Saenz, Luis, Tayman, K. E., Brown, Gabriel T., Kerr-Layton, Liana, Berriman-Rozen, Zachary D., Hiatt, Quinn, Kalra, Etash, Ong, Jason, Vadayar, Shreenija, Shannahan, Callie D., Benke, Evan, zhang, Jinhua, Geisman, Jane, Martyr, Cara, Ameijenda, Federico, Akruwala, Ushmi H., Nehring, Molly, Kissner, Natalie, Rule, Ian C., Learned, Tyler, Smith, Alexandra N., Mazzotta, Liam, Rounsefell, Tyndall, Eyeson, Elizabeth A., Shelby, Arlee K., Moll, Tyler S, Menke, Riley, Shahba, Hannan, House Jr., Tony A., Clark, David B., Burns, Annemarie C., de La Beaujardiere, Tristan, Trautwein, Emily D., Plantz, Will, Reeves, Justin, Faber, Ian, Buxton, B. W., Highhouse, Nigel, Landrey, Kalin, Hansen, Connor M, Chen, Kevin, Hales, Ryder Buchanan, Borgerding, Luke R., Guo, Mutian, Crow, Christian J., Whittall, Lloyd C., Simmons, Conor, Folarin, Adeduni, Parkinson, Evan J., Rahn, Anna L., Blevins, Olivia, Morelock, Annalise M., Kelly, Nicholas, Parker, Nathan L., Smith, Kelly, Plzak, Audrey E., Saeb, David, Hares, Cameron T., Parker, Sasha R., McCoy, Andrew, Pham, Alexander V., Lauzon, Megan, Kennedy, Cayla J., Reyna, Andrea B., Acosta, Daniela M. Meza, Cool, Destiny J., Steinbarth, Sheen L., Mendoza-Anselmi, Patricia, Plutt, Kaitlyn E., Kipp, Isabel M, Rakhmonova, M., Brown, Cameron L., Van Anne, Gabreece, Moss, Alexander P., Golden, Olivia, Kirkpatrick, Hunter B., Colleran, Jake R., Sullivan, Brandon J, Tran, Kevin, Carpender, Michael Andrew, Mundy, Aria T., Koenig, Greta, Oudakker, Jessica, Engelhardt, Rasce, Ales, Nolan, Wexler, Ethan Benjamin, Beato, Quinn I, Chen, Lily, Cochran, Brooke, Hill, Paula, Hamilton, Sean R., Hashiro, Kyle, Khan, Usman, Martinez, Alexa M., Brockman, Jennifer L., Mallory, Macguire, Reed, Charlie, Terrile, Richard, Singh, Savi, Watson, James Adam, Creany, Joshua B., Price, Nicholas K., Miften, Aya M., Tran, Bryn, Kamenetskiy, Margaret, Martinez, Jose R., Opp, Elena N., Huang, Jianyang, Fails, Avery M., Belei, Brennan J., Slocum, Ryan, Astalos, Justin, East, Andrew, Nguyen, Lena P., Pherigo, Callie C, East, Andrew N., Li, David Y., Nelson, Maya LI, Taylor, Nicole, Odbayar, Anand, Rives, Anna Linnea, Mathur, Kabir P., Billingsley, Jacob, Polikoff, Hyden, Driscoll, Michael, Wilson, Orion K., Lahmers, Kyle, Toon, Nathaniel J., Lippincott, Sam, Musgrave, Andrew J., Gregory, Alannah H., Pitsuean-Meier, Sedique, Jesse, Trevor, Smith, Corey, Miles, Ethan J., Kainz, Sabrina J. H. T., Ji, Soo Yeun, Nguyen, Lena, Aryan, Maryam, Dinser, Alexis M., Shortman, Jadon, Bastias, Catalina S, Umbricht, Thomas D, Cage, Breonna, Randolph, Parker, Pollard, Matthew, Simone, Dylan M., Aramians, Andrew, Brecl, Ariana E., Robert, Amanda M., Zenner, Thomas, Saldi, Maxwell, Morales, Gavin, Mendez, Citlali, Syed, Konner, Vogel, Connor Maklain, Cone, Rebecca A., Berhanu, Naomi, Carpenter, Emily, Leoni, Cecilia, Bryan, Samuel, Ramachandra, Nidhi, Shaw, Timothy, Lee, E. C., Monyek, Eli, Wegner, Aidan B., Sharma, Shajesh, Lister, Barrett, White, Jamison R., Willard, John S., Sulaiman, S. A, Blandon, Guillermo, Narayan, Anoothi, Ruger, Ryan, Kelley, Morgan A., Moreno, Angel J., Balcer, Leo M, Ward-Chene, N. R. D., Shelby, Emma, Reagan, Brian D., Marsh, Toni, Sarkar, Sucheta, Kelley, Michael P., Fell, Kevin, Balaji, Sahana, Hildebrand, Annalise K., Shoha, Dominick, Nandu, Kshmya, Tucker, Julia, Cancio, Alejandro R., Wang, Jiawei, Rapaport, Sarah Grace, Maravi, Aimee S., Mayer, Victoria A., Miller, Andrew, Bence, Caden, Koke, Emily, Fauntleroy, John T, Doermer, Timothy, Al-Ghazwi, Adel, Morgan, Remy, Alahmed, Mohammed S., Mathavan, Adam Izz Khan Mohd Reduan, Silvester, H. K., Weiner, Amanda M., Liu, Nianzi, Iovan, Taro, Jensen, Alexander V., AlHarbi, Yazeed A., Jiang, Yufan, Zhang, Jiaqi, Jones, Olivia M., Huang, Chenqi, Reh, Eileen N., Alhamli, Dania, Pettine, Joshua, Zhou, Chongrui, Kriegman, Dylan, Yang, Jianing, Ash, Kevin, Savage, Carl, Kaiser, Emily, Augenstein, Dakota N., Padilla, Jacqueline, Stark, Ethan K., Hansen, Joshua A., Kokes, Thomas, Huynh, Leslie, Sanchez-Sanchez, Gustavo, Jeseritz, Luke A., Carillion, Emma L., Vepa, Aditya V., Khanal, Sapriya, Behr, Braden, Martin, Logan S., McMullan, Jesse J., Zhao, Tianwei, Williams, Abigail K., Alqabani, Emeen, Prinster, Gale H., Horne, Linda, Ruggles-Delgado, Kendall, Otto, Grant, Gomez, Angel R., Nguyen, Leonardo, Brumley, Preston J., Venegas, Nancy Ortiz, Varela, Ilian, Brownlow, Jordi, Cruz, Avril, Leiker, Linzhi, Batra, Jasleen, Hutabarat, Abigail P., Nunes-Valdes, Dario, Jameson, Connor, Naqi, Abdulaziz, Adams, Dante Q., Biediger, Blaine B., Borelli, William T, Cisne, Nicholas A., Collins, Nathaniel A., Curnow, Tyler L., Gopalakrishnan, Sean, Griffin, Nicholas F., Herrera, Emanuel, McGarvey, Meaghan V., Mellett, Sarah, Overchuk, Igor, Shaver, Nathan, Stratmeyer, Cooper N., Vess, Marcus T., Juels, Parker, Alyami, Saleh A., Gale, Skylar, Wallace, Steven P., Hunter, Samuel C, Lonergan, Mia C., Stewart, Trey, Maksimuk, Tiffany E., Lam, Antonia, Tressler, Judah, Napoletano, Elena R., Miller, Joshua B., Roy, Marc G., Chanders, Jasey, Fischer, Emmalee, Croteau, A. J., Kuiper, Nicolas A., Hoffman, Alex, DeBarros, Elyse, Curry, Riley T., Brzostowicz, A., Courtney, Jonas, Zhao, Tiannie, Szabo, Emi, Ghaith, Bandar Abu, Slyne, Colin, Beck, Lily, Quinonez, Oliver, Collins, Sarah, Madonna, Claire A., Morency, Cora, Palizzi, Mallory, Herwig, Tim, Beauprez, Jacob N., Ghiassi, Dorsa, Doran, Caroline R., Yang, Zhanchao, Padgette, Hannah M., Dicken, Cyrus A., Austin, Bryce W., Phalen, Ethan J., Xiao, Catherine, Palos, Adler, Gerhardstein, Phillip, Altenbern, Ava L., Orbidan, Dan, Dorr, Jackson A., Rivas, Guillermo A., Ewing, Calvin A, Giebner, B. C., McEntee, Kelleen, Kite, Emily R., Crocker, K. A., Haley, Mark S., Lezak, Adrienne R., McQuaid, Ella, Jeong, Jacob, Albaum, Jonathan, Hrudka, E. M., Mulcahy, Owen T., Tanguma, Nolan C., Oishi-Holder, Sean, White, Zachary, Coe, Ryan W., Boyer, Christine, Chapman, Mitchell G., Fortino, Elise, Salgado, Jose A., Hellweg, Tim, Martinez, Hazelia K., Mitchell, Alexander J., Schubert, Stephanie H., Schumacher, Grace K, Tesdahl, Corey D, Uphoff, C. H., Vassilyev, Alexandr, Witkoff, Briahn, Wolle, Jackson R., Dice, Kenzie A., Behrer, Timothy A., Bowen, Troy, Campbell, Andrew J, Clarkson, Peter C, Duong, Tien Q., Hawat, Elijah, Lopez, Christian, Olson, Nathaniel P., Osborn, Matthew, Peou, Munisettha E., Vaver, Nicholas J., Husted, Troy, Kallemeyn, Nicolas Ian, Spangler, Ava A, Mccurry, Kyle, Schultze, Courtney, Troisi, Thomas, Thomas, Daniel, Ort, Althea E., Singh, Maya A., Soon, Caitlin, Patton, Catherine, Billman, Jayce A., Jarvis, Sam, Hitt, Travis, Masri, Mirna, Albalushi, Yusef J., Schofer, Matthew J, Linnane, Katherine B., Knott, Philip Whiting, Valencia, Whitney, Arias-Robles, Brian A., Ryder, Diana, Simone, Anna, Abrams, Jonathan M., Belknap, Annelene L., Rouse, Charlotte, Reynolds, Alexander, Petric, Romeo S. L., Gomez, Angel A., Meiselman-Ashen, Jonah B., Carey, Luke, Dias, John S., Fischer-White, Jules, Forbes, Aidan E., Galarraga, Gabriela, Kennedy, Forrest, Lawlor, Rian, Murphy, Maxwell J., Norris, Cooper, Quarderer, Josh, Waller, Caroline, Weber, Robert J., Gunderson, Nicole, Boyne, Tom, Gregory, Joshua A., Propper, Henry Austin, von Peccoz, Charles B. Beck, Branch, Donovan, Clarke, Evelyn, Cutler, Libby, Dabberdt, Frederick M., Das, Swagatam, Figueirinhas, John Alfred D., Fougere, Benjamin L., Roy, Zoe A., Zhao, Noah Y., Cox, Corben L., Barnhart, Logan D. W., Craig, Wilmsen B., Moll, Hayden, Pohle, Kyle, Mueller, Alexander, Smith, Elena K., Spicer, Benjamin C., Aycock, Matthew C., Bat-Ulzii, Batchimeg, Murphy, Madalyn C., Altokhais, Abdullah, Thornally, Noah R., Kleinhaus, Olivia R., Sarfaraz, Darian, Barnes, Grant M., Beard, Sara, Banda, David J, Davis, Emma A. B., Huebsch, Tyler J., Wagoner, Michaela, Griego, Justus, Hale, Jack J. Mc, Porter, Trevor J., Abrashoff, Riley, Phan, Denise M., Smith, Samantha M., Srivastava, Ashish, Schlenker, Jared A. W., Madsen, Kasey O., Hirschmann, Anna E., Rankin, Frederick C, Akbar, Zainab A., Blouin, Ethan, Coleman-Plante, Aislinn, Hintsa, Evan, Lookhoff, Emily, Amer, Hamzi, Deng, Tianyue, Dvorak, Peter, Minimo, Josh, Plummer, William C., Ton, Kelly, Solt, Lincoln, AlAbbas, Batool H., AlAwadhi, Areej A., Cooper, Nicholas M., Corbitt, Jessica S, Dunlap, Christian, Johnson, Owen, Malone, Ryan A., Tellez, Yesica, Wallace, Logan, Ta, Michael-Tan D., Wheeler, Nicola H., Ramirez, Ariana C., Huang, Shancheng, Mehidic, Amar, Christiansen, Katherine E, Desai, Om, Domke, Emerson N., Howell, Noah H., Allsbrook, Martin, Alnaji, Teeb, England, Colin, Siles, Nathan, Burton, Nicholas David, Cruse, Zoe, Gilmartin, Dalton, Kim, Brian T., Hattendorf, Elsie, Buhamad, Maryam, Gayou, Lily, Seglem, Kasper, Alkhezzi, Tameem, Hicks, Imari R., Fife, Ryann, Pelster, Lily M., Fix, Alexander, Sur, Sohan N., Truong, Joshua K., Kubiak, Bartlomiej, Bondar, Matthew, Shi, Kyle Z., Johnston, Julia, Acevedo, Andres B., Lee, Junwon, Solorio, William J., Johnston, Braedon Y., McCormick, Tyler, Olguin, Nicholas, Pastor, Paige J., Wilson, Evan M., Trunko, Benjamin L., Sjoroos, Chris, Adams, Kalvyn N, Bell, Aislyn, Brumage-Heller, Grant, Canales, Braden P., Chiles, Bradyn, Driscoll, Kailer H., Hill, Hallie, Isert, Samuel A., Ketterer, Marilyn, Kim, Matthew M., Mewhirter, William J., Phillips, Lance, Phommatha, Krista, Quinn, Megan S., Reddy, Brooklyn J., Rippel, Matthew, Russell, Bowman, Williams, Sajan, Pixley, Andrew M., Gapin, Keala C., Peterson, B., Ruprecht, Collin, Hardie, Isabelle, Li, Isaac, Erickson, Abbey, Gersabeck, Clint, Gopalani, Mariam, Allanqawi, Nasser, Burton, Taylor, Cahn, Jackson R., Conti, Reese, White, Oliver S., Rojec, Stewart, Hogen, Blake A., Swartz, Jason R., Dick, R., Battist, Lexi, Dunn, Gabrielle M., Gasser, Rachel, Logan, Timothy W., Sinkovic, Madeline, Schaller, Marcus T., Heintz, Danielle A., Enrich, Andrew, Sanchez, Ethan S., Perez, Freddy, Flores, Fernando, Kapla, Shaun D., Shockley, Michael C., Phillips, Justin, Rumley, Madigan, Daboub, Johnston, Karsh, Brennan J., Linders, Bridget, Chen, Sam, Do, Helen C., Avula, Abhinav, French, James M., Bertuccio, Chrisanna, Hand, Tyler, Lee, Adrianna J., Neeland, Brenna K, Salazar, Violeta, Andrew, Carter, Barmore, Abby, Beatty, Thomas, Alonzi, Nicholas, Brown, Ryan, Chandler, Olivia M., Collier, Curran, Current, Hayden, Delasantos, Megan E., Bonilla, Alberto Espinosa de los Monteros, Fowler, Alexandra A., Geneser, Julianne R., Gentry, Eleanor, Gustavsson, E. R., Hansson, Jonathan, Hao, Tony Yunfei, Herrington, Robert N., Kelly, James, Kelly, Teagan, Kennedy, Abigail, Marquez, Mathew J., Meillon, Stella, Palmgren, Madeleine L., Pesce, Anneliese, Ranjan, Anurag, Robertson, Samuel M., Smith, Percy, Smith, Trevor J, Soby, Daniel A., Stratton, Grant L., Thielmann, Quinn N., Toups, Malena C., Veta, Jenna S., Young, Trenton J., Maly, Blake, Manzanares, Xander R., Beijer, Joshua, George, Jacob D., Mills, Dylan P., Ziebold, Josh J, Chambers, Paige, Montoya, Michael, Cheang, Nathan M., Anderson, Hunter J., Duncan, Sheridan J., Ehrlich, Lauren, Hudson, Nathan C., Kiechlin, Jack L., Koch, Will, Lee, Justin, Menassa, Dominic, Oakes, S. H., Petersen, Audrey J., Bunsow, J. R. Ramirez, Bay, Joshua, Ramirez, Sacha, Fenwick, Logan D., Boyle, Aidan P., Hibbard, Lea Pearl, Haubrich, Calder, Sherry, Daniel P., Jenkins, Josh, Furney, Sebastian, Velamala, Anjali A., Krueger, Davis J., Thompson, William N., Chhetri, Jenisha, Lee, Alexis Ying-Shan, Ray, Mia G. V., Recchia, John C., Lengerich, Dylan, Taulman, Kyle, Romero, Andres C., Steward, Ellie N., Russell, Sloan, Hardwick, Dillon F., Wootten, Katelynn, Nguyen, Valerie A., Quispe, Devon, Ragsdale, Cameron, Young, Isabel, Atchley-Rivers, N. S., Stribling, Jordin L., Gentile, Julia G, Boeyink, Taylor A., Kwiatkowski, Daniel, Dupeyron, Tomi Oshima, Crews, Anastasia, Shuttleworth, Mitchell, Dresdner, Danielle C., Flackett, Lydia, Haratsaris, Nicholas, Linger, Morgan I, Misener, Jay H., Patti, Samuel, Pine, Tawanchai P., Marikar, Nasreen, Matessi, Giorgio, Routledge, Allie C., Alkaabi, Suhail, Bartman, Jessica L., Bisacca, Gabrielle E., Busch, Celeste, Edwards, Bree, Staudenmier, Caitlyn, Starling, Travis, McVey, Caden, Montano, Maximus, Contizano, Charles J., Taylor, Eleanor, McIntyre, James K., Victory, Andrew, McCammon, Glen S., Kimlicko, Aspen, Sheldrake, Tucker, Shelchuk, Grace, Von Reich, Ferin J., Hicks, Andrew J., O'neill, Ian, Rossman, Beth, Taylor, Liam C., MacDonald, William, Becker, Simone E., Han, Soonhee, O'Sullivan, Cian, Wilcove, Isaac, Brennan, David J., Hanley, Luke C., Hull, Owen, Wilson, Timothy R., Kalmus, Madison H., Berv, Owen A., Harris, Logan Swous, Doan, Chris H, Londres, Nathan, Parulekar, Anish, Adam, Megan M., Angwin, Abigail, Cabbage, Carter C., Colleran, Zachary, Pietras, Alex, Seux, Octave, Oros, Ryan, Wilkinson, Blake C., Nguyen, Khoa D, Trank-Greene, Maedee, Barone, Kevin M., Snyder, G. L., Biehle, Samuel J, Billig, Brennen, Almquist, Justin Thomas, Dixon, Alyssa M., Erickson, Benjamin, Evans, Nathan, Genne, SL, Kelly, Christopher M, Marcus, Serafima M., Ogle, Caleb, Patel, Akhil, Vendetti, Evan, Courtney, Olivia, Deel, Sean, Del Foco, Leonardo, Gjini, Michael, Haines, Jessica, Hoff, Isabelle J., Jones, M. R., Killian, Dominic, Kuehl, Kirsten, Kuester, Chrisanne, Lantz, Maxwell B., Lee, Christian J, Mauer, Graham, McKemey, Finbar K., Millican, Sarah J., Rosasco, Ryan, Stewart, T. C., VanEtten, Eleanor, Derwin, Zachary, Serio, Lauren, Sickler, Molly G., Blake, Cassidy A., Patel, Neil S., Fox, Margaret, Gray, Michael J, Ziegler, Lucas J., Kumar, Aman Priyadarshi, Polly, Madelyn, Mesgina, Sarah, McMorris, Zane, Griffin, Kyle J., Haile, L. N., Bassel, Claire, Dixon, Thomas J., Beattie, Ryan, Houck, Timothy J, Rodgers, Maeve, Trofino, Tyson R., Lukianow, Dax, Smart, Korben, Hall, Jacqueline L., Bone, Lauren, Baldwin, James O., Doane, Connor, Almohsen, Yousef A., Stamos, Emily, Acha, Iker, Kim, Jake, Samour II, Antonio E., Chavali, S., Kanokthippayakun, Jeerakit, Gotlib, Nicholas, Murphy, Ryan C., Archibald, Jack. W., Brimhall, Alexander J, Boyer, Aidan, Chapman, Logan T., Chadda, Shivank, Sibrell, Lisa, Vallery, Mia M., Conroy, Thomas C., Pan, Luke J., Balajonda, Brian, Fuhrman, Bethany E. S., Alkubaisi, Mohamed, Engelstad, Jacob, Dodrill, Joshua, Fuchs, Calvin R., Bullard-Connor, Gigi, Alhuseini, Isehaq, Zygmunt, James C., Sipowicz, Leo, Hayrynen, Griffin A., McGill, Riley M., Keating, Caden J., Hart, Omer, Cyr, Aidan St., Steinsberger, Christopher H., Thoman, Gerig, Wood, Travis M., Ingram, Julia A., Dominguez, J., Georgiades, Nathaniel James, Johnson, Matthew, Johnson, Sawyer, Pedersen, Alexander J., Ralapanawe, Anoush K, Thomas, Jeffrey J., Sato, Ginn A., Reynolds, Hope, Nasser, Liebe, Mizzi, Alexander Z., Damgaard, Olivia, Baflah, Abdulrahman A., Liu, Steven Y., Salindeho, Adam D., Norden, Kelso, Gearhart, Emily E., Krajnak, Zack, Szeremeta, Philip, Amos, Meggan, Shin, Kyungeun, Muckenthaler, Brandon A., Medialdea, Melissa, Beach, Simone, Wilson, Connor B., Adams, Elena R, Aldhamen, Ahmed, Harris, Coyle M., Hesse, Troy M., Golding, Nathan T., Larter, Zachary, Hernandez, Angel, Morales, Genaro, Traxler, Robert B., Alosaimi, Meshal, Fitton, Aidan F., Aaron, James Holland, Lee, Nathaniel F., Liao, Ryan Z., Chen, Judy, French, Katherine V., Loring, Justin, Colter, Aurora, McConvey, Rowan, Colozzi, Michael, Vann, John D., Scheck, Benjamin T., Weigand, Anthony A, Alhabeeb, Abdulelah, Idoine, Yolande, Woodard, Aiden L., Medellin, Mateo M., Ratajczyk, Nicholas O, Tobin, Darien P., Collins, Jack C., Horning, Thomas M., Pellatz, Nick, Pitten, John, Lordi, Noah, Patterson, Alyx, Hoang, Thi D, Zimmermann, Ingrid H, Wang, Hongda, Steckhahn, Daniel, Aradhya, Arvind J., Oliver, Kristin A., Cai, Yijian, Wang, Chaoran, Yegovtsev, Nikolay, Wu, Mengyu, Ganesan, Koushik, Osborne, Andrew, Wickenden, Evan, Meyer, Josephine C., Chaparro, David, Visal, Aseem, Liu, Haixin, Menon, Thanmay S., Jin, Yan, Wilson, John, Erikson, James W., Luo, Zheng, Shitara, Nanako, Nelson, Emma E, Geerdts, T. R., Ortiz, Jorge L Ramirez, and Lewandowski, H. J.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Flare frequency distributions represent a key approach to addressing one of the largest problems in solar and stellar physics: determining the mechanism that counter-intuitively heats coronae to temperatures that are orders of magnitude hotter than the corresponding photospheres. It is widely accepted that the magnetic field is responsible for the heating, but there are two competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To date, neither can be directly observed. Nanoflares are, by definition, extremely small, but their aggregate energy release could represent a substantial heating mechanism, presuming they are sufficiently abundant. One way to test this presumption is via the flare frequency distribution, which describes how often flares of various energies occur. If the slope of the power law fitting the flare frequency distribution is above a critical threshold, $\alpha=2$ as established in prior literature, then there should be a sufficient abundance of nanoflares to explain coronal heating. We performed $>$600 case studies of solar flares, made possible by an unprecedented number of data analysts via three semesters of an undergraduate physics laboratory course. This allowed us to include two crucial, but nontrivial, analysis methods: pre-flare baseline subtraction and computation of the flare energy, which requires determining flare start and stop times. We aggregated the results of these analyses into a statistical study to determine that $\alpha = 1.63 \pm 0.03$. This is below the critical threshold, suggesting that Alfv\'en waves are an important driver of coronal heating., Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The Astrophysical Journal on 2023-05-09, volume 948, page 71
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- 2023
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4. Direct In-Situ Capture, Separation and Visualization of Biological Particles with Fluid-Screen in the Context of Venus Life Finder Mission Concept Study
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Weber, Robert E., Petkowski, Janusz J., and Weber, Monika U.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Quantitative Biology - Other Quantitative Biology - Abstract
Evidence of chemical disequilibria and other anomalous observations in the Venusian atmosphere motivate the search for life within the planet's temperate clouds. To find signs of a Venusian aerial biosphere, a dedicated astrobiological space mission is required. Venus Life Finder (VLF) missions encompass unique mission concepts with specialized instruments to search for habitability indicators, biosignatures and even life itself. A key in the search for life is direct capture, concentration and visualization of particles of biological potential. Here, we present a short overview of Fluid-Screen (FS) technology, a recent advancement in the dielectrophoretic (DEP) microbial particle capture, concentration and separation. FS is capable of capturing and separating biochemically diverse particles, including multicellular molds, eukaryotic cells, different species of bacteria and even viruses, based on particle dielectric properties. In this short communication, we discuss the possible implementation of Fluid-Screen in the context of the VLF missions, emphasizing the unique science output of the Fluid-Screen instrument. FS can be coupled with other highly sophisticated instruments such as an autofluorescence microscope or a laser desorption mass spectrometer. We discuss possible configurations of Fluid-Screen that upon modification and testing, could be adapted for Venus. We discuss the unique science output of the FS technology that can capture biological particles in their native state and hold them in the focal plane of the microscope for the direct imaging of the captured material. We discuss the challenges for the proposed method posed by the concentrated sulfuric acid environment of Venus' clouds. While Venus' clouds are a particularly challenging environment, other bodies of the solar system, e.g., with liquid water present, might be especially suitable for Fluid-Screen application., Comment: Published in Aerospace as a part of the Special Issue "The Search for Signs of Life on Venus: Science Objectives and Mission Designs" (https://www.mdpi.com/journal/aerospace/special_issues/Search_Life_Venus_Science_Objectives_Mission_Designs)
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- 2022
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5. The Cover
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Overmier, Judith A. and Weber, Robert K
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- 2003
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6. Behavior Change for Low-Income Individuals Resulting from a Cooperative Extension Financial Capability Program
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Tobe, Erica, Eschbach, Cheryl, Weber, Robert, Ortquist, Jinnifer, and Hendrian, William V.
- Abstract
An evaluation was implemented over a 3-year period to assess a statewide financial capability program for low-income, diverse clientele in Michigan. Pre- and post- program evaluation data was used to determine knowledge gain and intended behavior change. Follow-up evaluation data confirmed behavior changes across 10 financial practices. Using the Transtheoretical Model of Behavior Change, research findings revealed participants were better able to maintain change in key financial practices including making wise money decisions, creating a spending plan, and managing debt as a result of the educational program. Recommendations are provided to support future programs with similar clientele.
- Published
- 2021
7. Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution
- Author
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Murrow, Lyndsay M, Weber, Robert J, Caruso, Joseph A, McGinnis, Christopher S, Phong, Kiet, Gascard, Philippe, Rabadam, Gabrielle, Borowsky, Alexander D, Desai, Tejal A, Thomson, Matthew, Tlsty, Thea, and Gartner, Zev J
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,Breast Cancer ,Prevention ,Estrogen ,Contraception/Reproduction ,Obesity ,Cancer ,2.1 Biological and endogenous factors ,Underpinning research ,1.1 Normal biological development and functioning ,Aetiology ,Metabolic and endocrine ,Breast ,Cell Communication ,Estrogens ,Female ,Humans ,Pregnancy ,Progesterone ,cell-cell interactions ,hormone signaling ,human breast ,sample heterogeneity ,scRNA-seq ,single-cell genomics ,Biochemistry and cell biology - Abstract
The rise and fall of estrogen and progesterone across menstrual cycles and during pregnancy regulates breast development and modifies cancer risk. How these hormones impact each cell type in the breast remains poorly understood because they act indirectly through paracrine networks. Using single-cell analysis of premenopausal breast tissue, we reveal a network of coordinated transcriptional programs representing the tissue-level response to changing hormone levels. Our computational approach, DECIPHER-seq, leverages person-to-person variability in breast composition and cell state to uncover programs that co-vary across individuals. We use differences in cell-type proportions to infer a subset of programs that arise from direct cell-cell interactions regulated by hormones. Further, we demonstrate that prior pregnancy and obesity modify hormone responsiveness through distinct mechanisms: obesity reduces the proportion of hormone-responsive cells, whereas pregnancy dampens the direct response of these cells to hormones. Together, these results provide a comprehensive map of the cycling human breast.
- Published
- 2022
8. Aldosterone-independent regulation of K+ secretion in the distal nephron
- Author
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Demko, John, Weber, Robert, Pearce, David, and Saha, Bidisha
- Published
- 2024
- Full Text
- View/download PDF
9. Electrochemical upvaluing of waste plastic
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Weber, Robert S.
- Published
- 2024
- Full Text
- View/download PDF
10. Global zenith wet delay modeling with surface meteorological data and machine learning
- Author
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Li, Qinzheng, Böhm, Johannes, Yuan, Linguo, and Weber, Robert
- Published
- 2024
- Full Text
- View/download PDF
11. Recommendations for improving rigor and reproducibility in site specific characterization
- Author
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Wrasman, Cody J., Bell, Alexis T., Chandler, Bert D., Harris, James W., Kwon, Stephanie, Ball, Madelyn R., Krishna, Siddarth H., Khatib, Sheima J., Bollini, Praveen, Román-Leshkov, Yuriy, “Bean” Getsoian, Andrew, Weber, Robert S., Lercher, Johannes A., Liu, Dongxia, Resasco, Daniel E., Bates, Jason S., Hall, Jacklyn N., Lebrón-Rodríguez, Edgard A., Paz Herrera, Laura, Notestein, Justin M., and Schaidle, Joshua A.
- Published
- 2024
- Full Text
- View/download PDF
12. Application of the Total Variation Method in Near Real-Time GNSS Tropospheric Tomography
- Author
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Adavi, Zohreh, Weber, Robert, Freymueller, Jeffrey T., Series Editor, and Sánchez, Laura, Assistant Editor
- Published
- 2023
- Full Text
- View/download PDF
13. Corporate Podcasts als Instrument der B2B-Kommunikation – Narrativität in der Unternehmenskommunikation und die Konvergenz von Funktionen
- Author
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Banholzer, Volker M., Maciel, Nina Klimpel, Weber, Robert, Janich, Nina, Series Editor, Nielsen, Martin, Series Editor, Schmidt, Christopher M., Series Editor, Grove Ditlevsen, Marianne, editor, and Julius Pedersen, Anne Grethe, editor
- Published
- 2023
- Full Text
- View/download PDF
14. Earth Rotation and Its Parameters
- Author
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Halilovic, Dzana, Mulić, Medžida, Weber, Robert, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Ademović, Naida, editor, Mujčić, Edin, editor, Mulić, Medžida, editor, Kevrić, Jasmin, editor, and Akšamija, Zlatan, editor
- Published
- 2023
- Full Text
- View/download PDF
15. Mapping competence: operative entrustability assessments demonstrate competency profiles across cases central to plastic surgery training
- Author
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Puthumana, Joseph S., Kuo, Shih-Chiang Edward, Tiongco, Rafael P., Khan, Iman F., Megee, David M., Korentager, Richard A., Weber, Robert A., Jarrett, Nicole J., Lifchez, Scott D., Cooney, Damon S., and Cooney, Carisa M.
- Published
- 2023
- Full Text
- View/download PDF
16. An open-source software package for Precise Point Positioning: raPPPid
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Glaner, Marcus Franz and Weber, Robert
- Published
- 2023
- Full Text
- View/download PDF
17. High-Resolution Exposure Assessment for Volatile Organic Compounds in Two California Residences
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Lunderberg, David M, Misztal, Pawel K, Liu, Yingjun, Arata, Caleb, Tian, Yilin, Kristensen, Kasper, Weber, Robert J, Nazaroff, William W, and Goldstein, Allen H
- Published
- 2021
18. Measurement of Volatile Compounds for Real-Time Analysis of Soil Microbial Metabolic Response to Simulated Snowmelt.
- Author
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Kim, Junhyeong, Goldstein, Allen H, Chakraborty, Romy, Jardine, Kolby, Weber, Robert, Sorensen, Patrick O, Wang, Shi, Faybishenko, Boris, Misztal, Pawel K, and Brodie, Eoin L
- Subjects
global change biology ,microbial volatile compounds ,non-destructive sampling ,soil biogeochemistry ,soil metabolomics ,soil microbiome ,Environmental Science and Management ,Soil Sciences ,Microbiology - Abstract
Snowmelt dynamics are a significant determinant of microbial metabolism in soil and regulate global biogeochemical cycles of carbon and nutrients by creating seasonal variations in soil redox and nutrient pools. With an increasing concern that climate change accelerates both snowmelt timing and rate, obtaining an accurate characterization of microbial response to snowmelt is important for understanding biogeochemical cycles intertwined with soil. However, observing microbial metabolism and its dynamics non-destructively remains a major challenge for systems such as soil. Microbial volatile compounds (mVCs) emitted from soil represent information-dense signatures and when assayed non-destructively using state-of-the-art instrumentation such as Proton Transfer Reaction-Time of Flight-Mass Spectrometry (PTR-TOF-MS) provide time resolved insights into the metabolism of active microbiomes. In this study, we used PTR-TOF-MS to investigate the metabolic trajectory of microbiomes from a subalpine forest soil, and their response to a simulated wet-up event akin to snowmelt. Using an information theory approach based on the partitioning of mutual information, we identified mVC metabolite pairs with robust interactions, including those that were non-linear and with time lags. The biological context for these mVC interactions was evaluated by projecting the connections onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) network of known metabolic pathways. Simulated snowmelt resulted in a rapid increase in the production of trimethylamine (TMA) suggesting that anaerobic degradation of quaternary amine osmo/cryoprotectants, such as glycine betaine, may be important contributors to this resource pulse. Unique and synergistic connections between intermediates of methylotrophic pathways such as dimethylamine, formaldehyde and methanol were observed upon wet-up and indicate that the initial pulse of TMA was likely transformed into these intermediates by methylotrophs. Increases in ammonia oxidation signatures (transformation of hydroxylamine to nitrite) were observed in parallel, and while the relative role of nitrifiers or methylotrophs cannot be confirmed, the inferred connection to TMA oxidation suggests either a direct or indirect coupling between these processes. Overall, it appears that such mVC time-series from PTR-TOF-MS combined with causal inference represents an attractive approach to non-destructively observe soil microbial metabolism and its response to environmental perturbation.
- Published
- 2021
19. Heat transfer constraints and performance mapping of a closed liquid sorption heat storage process
- Author
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Fumey, Benjamin, Weber, Robert, and Baldini, Luca
- Published
- 2023
- Full Text
- View/download PDF
20. Corporate Podcasts als Instrument der B2B-Kommunikation – Narrativität in der Unternehmenskommunikation und die Konvergenz von Funktionen
- Author
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Banholzer, Volker M., primary, Maciel, Nina Klimpel, additional, and Weber, Robert, additional
- Published
- 2023
- Full Text
- View/download PDF
21. The Infrared Imaging Spectrograph (IRIS) for TMT: advancing the data reduction system
- Author
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Walth, Gregory L., Wright, Shelley A., Rundquist, Nils-Erik, Andersen, David, Chapin, Edward, Chisholm, Eric, Do, Tuan, Dunn, Jennifer, Ellerbroek, Brent, Gillies, Kim, Hayano, Yutaka, Johnson, Chris, Larkin, James, Nakamoto, Takashi, Riddle, Reed, Simard, Luc, Smith, Roger, Suzuki, Ryuji, Sohn, Ji Man, Weber, Robert, Weissd, Jason, and Zhang, Kai
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Infrared Imaging Spectrograph (IRIS) is the first light instrument for the Thirty Meter Telescope (TMT) that consists of a near-infrared (0.84 to 2.4 micron) imager and integral field spectrograph (IFS) which operates at the diffraction-limit utilizing the Narrow-Field Infrared Adaptive Optics System (NFIRAOS). The imager will have a 34 arcsec x 34 arcsec field of view with 4 milliarcsecond (mas) pixels. The IFS consists of a lenslet array and slicer, enabling four plate scales from 4 mas to 50 mas, multiple gratings and filters, which in turn will operate hundreds of individual modes. IRIS, operating in concert with NFIRAOS will pose many challenges for the data reduction system (DRS). Here we present the updated design of the real-time and post-processing DRS. The DRS will support two modes of operation of IRIS: (1) writing the raw readouts sent from the detectors and performing the sampling on all of the readouts for a given exposure to create a raw science frame; and (2) reduction of data from the imager, lenslet array and slicer IFS. IRIS is planning to save the raw readouts for a given exposure to enable sophisticated processing capabilities to the end users, such as the ability to remove individual poor seeing readouts to improve signal-to-noise, or from advanced knowledge of the point spread function (PSF). The readout processor (ROP) is a key part of the IRIS DRS design for writing and sampling of the raw readouts into a raw science frame, which will be passed to the TMT data archive. We discuss the use of sub-arrays on the imager detectors for saturation/persistence mitigation, on-detector guide windows, and fast readout science cases (< 1 second)., Comment: 14 pages, 5 figures, 6 tables, Proceeding 10707-112 of the SPIE Astronomical Telescopes + Instrumentation 2018
- Published
- 2018
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- View/download PDF
22. Earth Rotation and Its Parameters
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Halilovic, Dzana, primary, Mulić, Medžida, additional, and Weber, Robert, additional
- Published
- 2022
- Full Text
- View/download PDF
23. Disseminated Cutaneous and Osteoarticular Sporotrichosis Mimicking Pyoderma Gangrenosum
- Author
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Saeed, Lina, Weber, Robert J, Puryear, Sarah B, Bahrani, Eman, Peluso, Michael J, Babik, Jennifer M, Haemel, Anna, and Coates, Sarah J
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Arthritis ,Infection ,ulcer ,deep fungal infection ,septic arthritis ,Sporothrix ,disseminated fungal infection ,United States of America ,Clinical sciences ,Medical microbiology - Abstract
Disseminated sporotrichosis may present with inflammatory arthritis and cutaneous ulcerations that mimic noninfectious skin conditions such as pyoderma gangreonsum (PG). Sporotrichosis must therefore be ruled out before administering immunosuppressive agents for PG. Furthermore, dimorphic fungi such as sporotrichosis may grow as yeast in bacterial cultures, even before fungal cultures become positive. We present a case of disseminated cutaneous and osteoarticular sporotrichosis mimicking PG and describe the differential diagnosis and the diagnostic and treatment approach to this condition.
- Published
- 2019
24. Characterizing sources and emissions of volatile organic compounds in a northern California residence using space‐ and time‐resolved measurements
- Author
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Liu, Yingjun, Misztal, Pawel K, Xiong, Jianyin, Tian, Yilin, Arata, Caleb, Weber, Robert J, Nazaroff, William W, and Goldstein, Allen H
- Subjects
Earth Sciences ,Atmospheric Sciences ,Air Pollution ,Indoor ,California ,Construction Materials ,Cooking ,Environmental Monitoring ,Female ,Housing ,Humans ,Interior Design and Furnishings ,Male ,Middle Aged ,Seasons ,Volatile Organic Compounds ,air quality ,cooking ,material balance ,occupancy ,source apportionment ,ventilation ,Engineering ,Medical and Health Sciences ,Building & Construction ,Earth sciences ,Health sciences - Abstract
We investigate source characteristics and emission dynamics of volatile organic compounds (VOCs) in a single-family house in California utilizing time- and space-resolved measurements. About 200 VOC signals, corresponding to more than 200 species, were measured during 8 weeks in summer and five in winter. Spatially resolved measurements, along with tracer data, reveal that VOCs in the living space were mainly emitted directly into that space, with minor contributions from the crawlspace, attic, or outdoors. Time-resolved measurements in the living space exhibited baseline levels far above outdoor levels for most VOCs; many compounds also displayed patterns of intermittent short-term enhancements (spikes) well above the indoor baseline. Compounds were categorized as "high-baseline" or "spike-dominated" based on indoor-to-outdoor concentration ratio and indoor mean-to-median ratio. Short-term spikes were associated with occupants and their activities, especially cooking. High-baseline compounds indicate continuous indoor emissions from building materials and furnishings. Indoor emission rates for high-baseline species, quantified with 2-hour resolution, exhibited strong temperature dependence and were affected by air-change rates. Decomposition of wooden building materials is suggested as a major source for acetic acid, formic acid, and methanol, which together accounted for ~75% of the total continuous indoor emissions of high-baseline species.
- Published
- 2019
25. Speciated and total emission factors of particulate organics from burning western US wildland fuels and their dependence on combustion efficiency
- Author
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Jen, Coty N, Hatch, Lindsay E, Selimovic, Vanessa, Yokelson, Robert J, Weber, Robert, Fernandez, Arantza E, Kreisberg, Nathan M, Barsanti, Kelley C, and Goldstein, Allen H
- Subjects
CE-CERT - Published
- 2019
26. My Cancer Experience Taught Me to Put Patients First
- Author
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Weber, Robert J., primary
- Published
- 2022
- Full Text
- View/download PDF
27. Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation
- Author
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Krummel, Matthew F, Mahale, Jagdish N, Uhl, Lion FK, Hardison, Emily A, Mujal, Adriana M, Mazet, Julie M, Weber, Robert J, Gartner, Zev J, and Gérard, Audrey
- Subjects
Prevention ,Infectious Diseases ,Vaccine Related ,Biodefense ,1.1 Normal biological development and functioning ,Underpinning research ,Inflammatory and immune system ,Infection ,Animals ,CD8-Positive T-Lymphocytes ,Cell Differentiation ,Cellular Microenvironment ,Immunologic Memory ,Immunological Synapses ,Integrins ,Interferon-gamma ,Killer Cells ,Natural ,Listeria monocytogenes ,Lymph Nodes ,Lymphocyte Activation ,Mice ,Mice ,Inbred C57BL ,Paracrine Communication ,Primary Cell Culture ,Signal Transduction ,Spleen ,Tetradecanoylphorbol Acetate ,T cell differentiation ,cytokines ,cell biology ,integrins - Abstract
The cytokine IFN-γ is a critical regulator of immune system development and function. Almost all leukocytes express the receptor for IFN-γ, yet each cell type elicits a different response to this cytokine. Cell type-specific effects of IFN-γ make it difficult to predict the outcomes of the systemic IFN-γ blockade and limit its clinical application, despite many years of research. To better understand the cell-cell interactions and cofactors that specify IFN-γ functions, we focused on the function of IFN-γ on CD8 T cell differentiation. We demonstrated that during bacterial infection, IFN-γ is a dominant paracrine trigger that skews CD8 T cell differentiation toward memory. This skewing is preferentially driven by contact-dependent T cell-T cell (T-T) interactions and the localized IFN-γ secretion among activated CD8 T cells in a unique splenic microenvironment, and is less sensitive to concurrent IFN-γ production by other immune cell populations such as natural killer (NK) cells. Modulation of CD8 T cell differentiation by IFN-γ relies on a nonconventional IFN-γ outcome that occurs specifically within 24 hours following infection. This is driven by IFN-γ costimulation by integrins at T-T synapses, and leads to synergistic phosphorylation of the proximal STAT1 molecule and accelerated IL-2 receptor down-regulation. This study provides evidence of the importance of context-dependent cytokine signaling and gives another example of how cell clusters and the microenvironment drive unique biology.
- Published
- 2018
28. Changes in epithelial proportions and transcriptional state underlie major premenopausal breast cancer risks
- Author
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Murrow, Lyndsay M, Weber, Robert J, Caruso, Joseph A, McGinnis, Christopher S, Phong, Kiet, Gascard, Philippe, Borowsky, Alexander D, Desai, Tejal A, Thomson, Matthew, Tlsty, Thea, and Gartner, Zev J
- Subjects
Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Biological Sciences ,Prevention ,Aging ,Cancer ,Estrogen ,Breast Cancer ,Aetiology ,1.1 Normal biological development and functioning ,Underpinning research ,2.1 Biological and endogenous factors - Abstract
Abstract: The human breast undergoes lifelong remodeling in response to estrogen and progesterone, but hormone exposure also increases breast cancer risk. Here, we use single-cell analysis to identify distinct mechanisms through which breast composition and cell state affect hormone signaling. We show that prior pregnancy reduces the transcriptional response of hormone-responsive (HR+) epithelial cells, whereas high body mass index (BMI) reduces overall HR+ cell proportions. These distinct changes both impact neighboring cells by effectively reducing the magnitude of paracrine signals originating from HR+ cells. Because pregnancy and high BMI are known to protect against hormone-dependent breast cancer in premenopausal women, our findings directly link breast cancer risk with person-to-person heterogeneity in hormone responsiveness. More broadly, our findings illustrate how cell proportions and cell state can collectively impact cell communities through the action of cell-to-cell signaling networks.
- Published
- 2018
29. Speciated and total emission factors of particulate organics fromburning western U.S. wildland fuels and their dependence oncombustion efficiency
- Author
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Jen, Coty N, Hatch, Lindsay E, Selimovic, Vanessa, Yokelson, Robert J, Weber, Robert, Fernandez, Arantza E, Kreisberg, Nathan M, Barsanti, Kelley C, and Goldstein, Allen H
- Published
- 2018
30. “Impact of ACAPS Coordinated Interview Release Policy: Applicant and Program Attitudes, Adherence and Interview Trends”
- Author
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Davis, Greta L., Reghunathan, Meera, Dean, Riley A., Cronin, Brendan J., Weber, Robert A., and Gosman, Amanda A.
- Published
- 2022
- Full Text
- View/download PDF
31. Epidemiological and genetic characteristics of vancomycin-resistant Enterococcus faecium isolates in a University Children's Hospital in Germany: 2019 to 2020
- Author
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Trautmannsberger, Ilona, Kolberg, Laura, Meyer-Buehn, Melanie, Huebner, Johannes, Werner, Guido, Weber, Robert, Heselich, Valerie, Schroepf, Sebastian, Muench, Hans-Georg, and von Both, Ulrich
- Published
- 2022
- Full Text
- View/download PDF
32. Balancing sodium and potassium: Implication of mTORC2-mediated ENaC activation in DCT2 and early CNT for potassium balance in high dietary potassium
- Author
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Saha, Bidisha, primary, Takagi, Enzo, additional, Demko, John, additional, Weber, Robert, additional, Saha, Shrutirupa, additional, and Pearce, David, additional
- Published
- 2024
- Full Text
- View/download PDF
33. High Potassium Suppresses Glycosuria and Gluconeogenesis in Tubule-specific mTORC2 Knockout Mice
- Author
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Demko, John, primary, Saha, Bidisha, additional, Takagi, Enzo, additional, Weber, Robert, additional, and Pearce, David, additional
- Published
- 2024
- Full Text
- View/download PDF
34. The Infrared Imaging Spectrograph (IRIS) for TMT: Instrument Overview
- Author
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Larkin, James E., Moore, Anna M., Wright, Shelley A., Wincentsen, James E., Anderson, David, Chisholm, Eric M., Dekany, Richard G., Dunn, Jennifer S., Ellerbroek, Brent L., Hayano, Yutaka, Phillips, Andrew C., Simard, Luc, Smith, Roger, Suzuki, Ryuji, Weber, Robert W., Weiss, Jason L., and Zhang, Kai
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
IRIS is a near-infrared (0.84 to 2.4 microns) integral field spectrograph and wide-field imager being developed for first light with the Thirty Meter (TMT). It mounts to the advanced optics (AO) system NFIRAOS and has integrated on-instrument wavefront sensors (OIWFS) to achieve diffraction-limited spatial resolution at wavelengths longer than 1 micron. With moderate spectral resolution (R ~4,000 - 8,000) and large bandpass over a continuous field of view, IRIS will open new opportunities in virtually every area of astrophysical science. It will be able to resolve surface features tens of kilometers across Titan, while also mapping the distant galaxies at the scale of an individual star forming region. This paper summarizes the entire design and capabilities, and includes the results from the nearly completed preliminary design phase., Comment: 13 pages, SPIE proceeedings
- Published
- 2016
- Full Text
- View/download PDF
35. Quantitative assessment of motor impairment and surgical outcome in Hirayama disease with proximal involvement using motor unit number index
- Author
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Zheng, Chaojun, Zhu, Yu, Yu, Qifeng, Zhu, Dongqing, Li, Jun, Lyu, Feizhou, Weber, Robert, Qiao, Kai, and Jiang, Jianyuan
- Published
- 2021
- Full Text
- View/download PDF
36. Early surgery improves peripheral motor axonal dysfunction in acute traumatic central cord syndrome: A prospective cohort study
- Author
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Zheng, Chaojun, Zhu, Dongqing, Zhu, Yu, Lyu, Feizhou, Weber, Robert, Jin, Xiang, and Jiang, Jianyuan
- Published
- 2021
- Full Text
- View/download PDF
37. Application of the Total Variation Method in Near Real-Time GNSS Tropospheric Tomography
- Author
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Adavi, Zohreh, primary and Weber, Robert, additional
- Published
- 2022
- Full Text
- View/download PDF
38. Non-autonomous cell proliferation in the mammary gland and cancer.
- Author
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Weber, Robert J, Desai, Tejal A, and Gartner, Zev J
- Subjects
Macrophages ,Animals ,Humans ,Breast Neoplasms ,Cell Proliferation ,Tumor Microenvironment ,Breast Cancer ,Stem Cell Research - Nonembryonic - Human ,Cancer ,Stem Cell Research ,Underpinning research ,1.1 Normal biological development and functioning ,Generic health relevance ,Biochemistry and Cell Biology ,Developmental Biology - Abstract
Cells decide whether to grow and divide by integrating internal and external signals. Non-autonomous cell growth and proliferation occurs when microenvironmental signals from neighboring cells, both physical and secreted, license this decision. Understanding these processes is vital to developing an accurate framework for cell-cell interactions and cellular decision-making, and is useful for advancing new therapeutic strategies to prevent dysregulated growth. Here, we review some recent examples of non-autonomous cell growth in the mammary gland and tumor cell proliferation.
- Published
- 2017
39. Cycling test of liquid sorption thermal energy storage using sodium hydroxide
- Author
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Fumey, Benjamin, Weber, Robert, Baldini, Luca, Fumey, Benjamin, Weber, Robert, and Baldini, Luca
- Abstract
In this paper results of an absorption heat storage cycling test are presented. The specific application is long term heat storage, the test setup is based on a spiral finned tube heat and mass exchanger constructed of stainless steel type 1.4571 and the absorbent working pair is sodium hydroxide and water. A total of 7 cycles areperformed at approximately 13.5 hours of absorption and 17 hours of desorption time per cycle. Average concentration of sodium hydroxide in the solution is 48 wt% after desorption and 27 wt% after absorption. Comparison of thermal performance among different cycles is made. No clear tendency of cycling improvement or degradation is found., + ID der Publikation: hslu_101873 + Art des Beitrages: Referat/Vortrag + Veranstalter: International Solar Energy Society + Sprache: Englisch + Letzte Aktualisierung: 2024-03-21 08:20:27
- Published
- 2024
40. Impaired 11β-HSD1 Activity in a Male Patient With Cushing Disease Resulting in Lack of the Full Cushingoid Phenotype.
- Author
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Weber, Robert J, Kawaja, Christopher, Wallerstein, Robert, Kunwar, Sandeep M, and Liu, Chienying
- Subjects
- *
CUSHING'S syndrome , *GLUCOCORTICOID receptors , *CORTISONE , *HYDROCORTISONE , *ADRENOCORTICOTROPIC hormone - Abstract
We present a patient who had surgically confirmed CD but without the full cushingoid phenotype despite markedly elevated cortisol. Nonpathologic causes of elevated ACTH and cortisol were eliminated as were pathogenic variants in the glucocorticoid receptor gene. Further studies of urine metabolites, cortisol half-life, and the ratios of cortisone to cortisol conversion revealed impaired 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity. There have only been 2 prior reports of impaired 11β-HSD1 resulting in lack of classic cushingoid features in the past 2 decades. Our patient's presentation and previous reports demonstrate the key role of 11β-HSD1 in modulating intracellular cortisol concentration, therefore shielding the peripheral tissues from the effects of excess cortisol. When patients present with markedly elevated cortisol but without classic cushingoid features, impaired 11β-HSD1 should be considered in the differential diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Aldosterone-independent regulation of K+ secretion in the distal nephron.
- Author
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Demko, John, Weber, Robert, Pearce, David, and Saha, Bidisha
- Published
- 2024
- Full Text
- View/download PDF
42. Toward Rational Design of Nickel Catalysts for Thermocatalytic Decomposition of Methane for Carbon Dioxide‐Free Hydrogen and Value‐Added Carbon Co‐Product: A Review.
- Author
-
Weber, Robert S., Xu, Mengze, Lopez‐Ruiz, Juan A., Jiang, Changle, Hu, Jianli, and Dagle, Robert A.
- Subjects
- *
CHEMICAL vapor deposition , *CARBON emissions , *PARTICLE size distribution , *CARBON nanotubes , *PRICES - Abstract
Thermocatalytic decomposition of methane provides opportunities for hydrogen (H2) production with no emission of carbon dioxide. However, high‐value carbon products need to be produced for economic deployment of thermocatalytic decomposition and to achieve a minimum H2 selling price below the U.S, Department of Energy target of $ 1/kg H2. In this review, we re‐evaluate data on catalyst development reported in the literature and propose correlations between catalyst characteristics, catalytic stability, and properties of carbon co‐products. In the first part of the review, growth mechanisms for carbon nanotubes using state‐of‐the‐art chemical vapor deposition are reviewed to catalog the effects of catalyst characteristics, the influence of carbon sources, interactions between metal particles and supports, and metal particle sizes on carbon growth. In the second part, representative developments in mono‐, bi‐, and tri‐metallic nickel catalysts are highlighted. We present kinetic analysis of reactions catalyzed by mono‐metallic nickel catalysts, which generates a correlation between metal particle size and catalyst stability. Rational design of Ni‐based catalysts for TCD of methane requires attention to the size of the metal particle and effective normalization of the reaction rates. Further attention to the distribution of the metal particle sizes may help identify catalyst properties that contribute longevity and selectivity to processes that use them. While it is tempting to focus on the highest valued carbon products (e. g. CNTs and CFs), analysis of the markets for other carbon products suggests that a more flexible approach may generate comparable returns without the risk associated with specialization. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
43. Thirty years of VRE in Germany – “expect the unexpected”: The view from the National Reference Centre for Staphylococci and Enterococci
- Author
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Becker, Karsten, Borgmann, Stefan, Diefenbach, Andreas, Hamprecht, Axel, Hogardt, Michael, Wichelhaus, Thomas, Kemp, Volkhard, Huebner, Nils-Olaf, Kaasch, Achim, Geginat, Gernot, Kohnen, Wolfgang, Menzer, Alexander, Krause, T., Miethke, Thomas, Pranada, Felix, Radojn, Florian, Tobisch, Steffen, Jansen, Verena, Regnath, Thomas, Bührlen, Uwe, Schneider-Brachert, Wulf, Schwarz, Roman, Luemen, Michaela, Skov, Robert, Thuermer, Alexander, Baum, Heike von, Weig, Michael, Uwe, Groß, Zabel, Lutz, Wulffen, Hinrik von, Döring, Stefanie, Werner, Guido, Neumann, Bernd, Weber, Robert E., Kresken, Michael, Wendt, Constanze, and Bender, Jennifer K.
- Published
- 2020
- Full Text
- View/download PDF
44. Development and validation of a sensitive UHPLC-MS/MS analytical method for venetoclax in mouse plasma, and its application to pharmacokinetic studies
- Author
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Eisenmann, Eric D., Jin, Yan, Weber, Robert H., Sparreboom, Alex, and Baker, Sharyn D.
- Published
- 2020
- Full Text
- View/download PDF
45. Assessing the Correlation Between a Surgeon's Ability to Draw a Procedure and Ability to Perform the Procedure
- Author
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Weber, Robert A., Wong, Stacy, Allen, Samantha J., and Fornfeist, Douglas S.
- Published
- 2020
- Full Text
- View/download PDF
46. Toward Rational Design of Nickel Catalysts in Thermocatalytic Decomposition of Methane for Carbon Dioxide‐Free Hydrogen and Value‐Added Carbon Co‐Product: A Review
- Author
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Weber, Robert, primary, Xu, Mengze, additional, Lopez-Ruiz, Juan, additional, Jiang, Changle, additional, Hu, Jianli, additional, and Dagle, Robert, additional
- Published
- 2024
- Full Text
- View/download PDF
47. Antivirale Photodynamische Therapie bei Covid-19: Ein neuer Ansatz zur Behandlung in frühen Krankheitsstadien
- Author
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Weber, Michael, Mehran, Yasaman Zandi, Orthaber, Armin, Saadat, Hadi Hosseini, Weber, Robert, and Wojcik, Matthias
- Published
- 2021
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48. Rapid Organoid Reconstitution by Chemical Micromolding
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Weber, Robert J, Cerchiari, Alec E, Delannoy, Lucas S, Garbe, James C, LaBarge, Mark A, Desai, Tejal A, and Gartner, Zev J
- Subjects
Engineering ,Biomedical Engineering ,Biotechnology ,Genetics ,Bioengineering ,Regenerative Medicine ,Underpinning research ,1.1 Normal biological development and functioning ,Generic health relevance ,organoid ,synthetic biology ,3D tissue culture ,DNA programmed assembly ,microwell ,mammary gland ,Biomedical engineering - Abstract
Purified populations of cells can be reconstituted into organoids that recapitulate aspects of their in vivo structure and function. These organoids are useful as models of healthy and diseased tissue in the basic sciences, in vitro screens, and regenerative medicine. Existing strategies to reconstitute organoids from purified cells face obstacles with respect to cell-viability, multicellular connectivity, scalability, and compatibility with subsequent experimental or analytical techniques. To address these challenges, we developed a strategy for rapidly casting populations of cells into microtissues of prescribed size and shape. This approach begins by chemically remodeling the adhesive properties of living cells with membrane-anchored ssDNA with modest annealing kinetics. Populations of complementary labeled cells are then combined into microwells that rapidly mold the DNA-adhesive cell populations into 3D aggregates of uniform size and shape. Once formed, aggregates are removed from the molds in the presence of "capping" oligonucleotides that block hybridization of residual surface DNA between aggregates in suspension. Finally, transfer of aggregates to biomimetic gels for 3D culture completes the process of reconstitution. This strategy of chemical micromolding allows for control over aggregate internal topology and does not perturb the natural process of self-organization in primary human mammary epithelial cells.
- Published
- 2016
49. GM-CSF and ipilimumab therapy in metastatic melanoma: Clinical outcomes and immunologic responses
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Kwek, Serena S, Kahn, James, Greaney, Samantha K, Lewis, Jera, Cha, Edward, Zhang, Li, Weber, Robert W, Leonard, Lonnie, Markovic, Svetomir N, Fong, Lawrence, and Spitler, Lynn E
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Cancer ,Vaccine Related ,Immunization ,Clinical Trials and Supportive Activities ,Clinical Research ,6.2 Cellular and gene therapies ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,CD4(+) effector T cells ,CD8(+) T cells ,clinical trial ,CTLA-4 ,GM-CSF ,immunotherapy ,ipilimumab ,metastatic melanoma ,PD-1 ,CD4+ effector T cells ,CD8+ T cells ,Immunology ,Oncology and Carcinogenesis - Abstract
We conducted a phase II clinical trial of anti-CTLA-4 antibody (ipilimumab) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in 22 patients with metastatic melanoma and determined clinical outcomes and immunologic responses. The treatment consisted of a 3-mo induction with ipilimumab at 10 mg/kg administered every 3 weeks for four doses in combination with GM-CSF at 125 µg/m2 for 14 d beginning on the day of the ipilimumab infusion and then GM-CSF for 3 mo on the same schedule without ipilimumab. This was followed by maintenance therapy with the combination every 3 mo for up to 2 y or until disease progression or unacceptable toxicity. Blood samples for determination of immune subsets were obtained before treatment, at week 3 (end of cycle 1) and at week 6 (end of cycle 2). Blood samples were also obtained from seven subjects who were cancer-free. The immune response disease control (irDC) rate at 24 weeks was 41% and the overall response rate (ORR) was 32%. The median progression free-survival (PFS) was 3.5 mo and the median overall survival (OS) was 21.1 mo. 41% of the patients experienced Grade 3 to 4 adverse events. We conclude that this combination is safe and the results suggest the combination may be more effective than ipilimumab monotherapy. Further, the results suggest that lower levels of CD4+ effector T cells but higher levels of CD8+ T cells expressing PD-1 at pre-treatment could be a potential biomarker for disease control in patients who receive immunotherapy with ipilimumab and GM-CSF. Further trials of this combination are warranted.
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- 2016
50. Assessment of regularization techniques in GNSS tropospheric tomography based on single- and dual-frequency observations
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Adavi, Zohreh, Weber, Robert, and Glaner, Marcus Franz
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- 2022
- Full Text
- View/download PDF
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