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1. Process intensification education contributes to sustainable development goals. Part 2

Author

Fernandez Rivas, David, Boffito, Daria C., Faria-Albanese, Jimmy, Glassey, Jarka, Afraz, Nona, Akse, Henk, Boodhoo, Kamelia V.K., Bos, Rene, Cantin, Judith, (Emily) Chiang, Yi Wai, Commenge, Jean Marc, Dubois, Jean Luc, Galli, Federico, de Mussy, Jean Paul Gueneau, Harmsen, Jan, Kalra, Siddharth, Keil, Frerich J., Morales-Menendez, Ruben, Navarro-Brull, Francisco J., Noël, Timothy, Ogden, Kim, Patience, Gregory S., Reay, David, Santos, Rafael M., Smith-Schoettker, Ashley, Stankiewicz, A.I., van den Berg, Henk, van Gerven, Tom, van Gestel, Jeroen, van der Stelt, Michiel, van de Ven, Mark, Weber, R. S., Universidad de Alicante. Departamento de Química Física, Universidad de Alicante. Instituto Universitario de Electroquímica, Grupo de Fotoquímica y Electroquímica de Semiconductores (GFES), Micro Flow Chemistry and Synthetic Meth., Laboratoire Réactions et Génie des Procédés (LRGP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Mesoscale Chemical Systems, Catalytic Processes and Materials, and Sustainable Process Technology

Subjects
FLOW, General Chemical Engineering, UT-Hybrid-D, Social Sciences, 02 engineering and technology, ENERGY, DESIGN, ComputingMilieux_COMPUTERSANDEDUCATION, Technik [600], ComputingMilieux_MISCELLANEOUS, Pedagogy, 05 social sciences, 050301 education, SCIENCE, Education challenge, TIME, Sustainability, Work (electrical), ddc:540, SIMULATION, Process Intensification, Entrepreneurship, Technology and Engineering, STRATEGIES, Higher education, Process (engineering), Lifelong learning, Context (language use), 12. Responsible consumption, Education, Chemical engineering, 020401 chemical engineering, SYSTEMS, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Química Física, Industry challenge, 0204 chemical engineering, Education, Scientific Disciplines, Sustainable development, Chemie [540], business.industry, PERFORMANCE, Education & Educational Research, TRENDS, Engineering management, Process design, business, ddc:600, 0503 education
Abstract

Achieving the United Nations sustainable development goals requires industry and society to develop tools and processes that work at all scales, enabling goods delivery, services, and technology to large conglomerates and remote regions. Process Intensification (PI) is a technological advance that promises to deliver means to reach these goals, but higher education has yet to totally embrace the program. Here, we present practical examples on how to better teach the principles of PI in the context of the Bloom's taxonomy and summarise the current industrial use and the future demands for PI, as a continuation of the topics discussed in Part 1. In the appendices, we provide details on the existing PI courses around the world, as well as teaching activities that are showcased during these courses to aid students' lifelong learning. The increasing number of successful commercial cases of PI highlight the importance of PI education for both students in academia and industrial staff. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of Institution of Chemical Engineers. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Published
2020
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3. Process intensification education contributes to sustainable development goals. Part 2

Author

Fernandez Rivas, David (author), Boffito, Daria C. (author), Faria-Albanese, Jimmy (author), Glassey, Jarka (author), Afraz, Nona (author), Akse, Henk (author), Boodhoo, Kamelia V.K. (author), Bos, Rene (author), Cantin, Judith (author), (Emily) Chiang, Yi Wai (author), Commenge, Jean Marc (author), Dubois, Jean Luc (author), Galli, Federico (author), de Mussy, Jean Paul Gueneau (author), Harmsen, Jan (author), Kalra, Siddharth (author), Keil, Frerich J. (author), Morales-Menendez, Ruben (author), Navarro-Brull, Francisco J. (author), Noël, Timothy (author), Ogden, Kim (author), Patience, Gregory S. (author), Reay, David (author), Santos, Rafael M. (author), Smith-Schoettker, Ashley (author), Stankiewicz, A.I. (author), van den Berg, Henk (author), van Gerven, Tom (author), van Gestel, Jeroen (author), van der Stelt, Michiel (author), van de Ven, Mark (author), Weber, R. S. (author), Fernandez Rivas, David (author), Boffito, Daria C. (author), Faria-Albanese, Jimmy (author), Glassey, Jarka (author), Afraz, Nona (author), Akse, Henk (author), Boodhoo, Kamelia V.K. (author), Bos, Rene (author), Cantin, Judith (author), (Emily) Chiang, Yi Wai (author), Commenge, Jean Marc (author), Dubois, Jean Luc (author), Galli, Federico (author), de Mussy, Jean Paul Gueneau (author), Harmsen, Jan (author), Kalra, Siddharth (author), Keil, Frerich J. (author), Morales-Menendez, Ruben (author), Navarro-Brull, Francisco J. (author), Noël, Timothy (author), Ogden, Kim (author), Patience, Gregory S. (author), Reay, David (author), Santos, Rafael M. (author), Smith-Schoettker, Ashley (author), Stankiewicz, A.I. (author), van den Berg, Henk (author), van Gerven, Tom (author), van Gestel, Jeroen (author), van der Stelt, Michiel (author), van de Ven, Mark (author), and Weber, R. S. (author)

Abstract

Achieving the United Nations sustainable development goals requires industry and society to develop tools and processes that work at all scales, enabling goods delivery, services, and technology to large conglomerates and remote regions. Process Intensification (PI) is a technological advance that promises to deliver means to reach these goals, but higher education has yet to totally embrace the program. Here, we present practical examples on how to better teach the principles of PI in the context of the Bloom’s taxonomy and summarise the current industrial use and the future demands for PI, as a continuation of the topics discussed in Part 1. In the appendices, we provide details on the existing PI courses around the world, as well as teaching activities that are showcased during these courses to aid students’ lifelong learning. The increasing number of successful commercial cases of PI highlight the importance of PI education for both students in academia and industrial staff., Intensified Reaction and Separation Systems

Published
2020
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4. Diffeomorphic Temporal Alignment Nets

Author

Weber, R. S., Eyal, M., Detlefsen, N. S., Oren Shriki, and Freifeld, O.

Abstract

Time-series analysis is confounded by nonlinear time warping of the data. Traditional methods for joint alignment do not generalize: after aligning a given signal ensemble, they lack a mechanism, that does not require solving a new optimization problem, to align previously-unseen signals. In the multi-class case, they must also first classify the test data before aligning it. Here we propose the Diffeomorphic Temporal Alignment Net (DTAN), a learning-based method for time-series joint alignment. Via flexible temporal transformer layers, DTAN learns and applies an input-dependent nonlinear time warping to its input signal. Once learned, DTAN easily aligns previously-unseen signals by its inexpensive forward pass. In a single-class case, the method is unsupervised: the ground-truth alignments are unknown. In the multi-class case, it is semi-supervised in the sense that class labels (but not the ground-truth alignments) are used during learning; in test time, however, the class labels are unknown. As we show, DTAN not only outperforms existing joint-alignment methods in aligning training data but also generalizes well to test data. Our code is available at https://github.com/BGU-CS-VIL/dtan.

Published
2019

6. Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction

Author

Gupta, A. K., Mckenna, W. G., Weber, C. N., Machtay, M., David Rosenthal, Bakanauskas, V. J., Cerniglia, G. J., Bernhard, E. J., Feldman, M. D., Goldsmith, J. D., Muschel, R. J., Mick, R., and Weber, R. S.

Abstract

PURPOSE: Locoregional recurrence is the dominant form of treatment failure in head and neck (HandN) cancer. The epidermal growth factor receptor (EGFR) is frequently amplified in this disease (

Published
2002

7. Head and neck: Editorial

Author

Weber, R. S., Abemayor, E., Adams, G. L., Adelstein, D. J., Alavi, A., Alford, E., Al-Sarraf, M., Alvi, A., Ambinder, R., Amdur, R., Amedee, R. G., Anand, V. K., Andersen, P., Anderson, T., Ang, K. K., Antonelli, P. J., Ariyan, S., Aviv, J. E., Ayala, A., Baatenburg de Jong, R. J., Backous, D., Bailey, B. J., Baker, S., Baloch, Z. W., Barnes, E. L., Barrera, J., Bastian, R., Batsakis, J. G., Bauman, N., Becker, D., Beenken, S., Beitler, J. J., Berke, G., Blacklock, J. B., Blackwell, K., Blitzer, A., Blom, E., Bolger, W. E., Bone, R. C., Boyd, J., Boyd, D., Boyle, J., Braakhuis, B., Bradford, C., Bradley, P. J., Brakenhoff, R., Breitbart, W., Brizel, D., Brock, W. A., Brown, R. E., Brown, A., Buatti, J., Burgess, M. A., Burkey, B., Busse, P., Byers, R. M., Cabanillas, F., Cady, B., Calcaterra, T., Calhoun, K., Califano J., Jr, Callender, D. L., Campbell, B. H., Carew, J., Carey, T. E., Carrau, R. L., Carroll, W. R., Cassisi, N. J., Chalian, A. A., Charous, S., Chen, A., Cheney, M., Cheville, A., Chonkich, G., Chonkick, G., Civantos, F., Clark, K. F., Clayman, G., Close, L. G., Cohen, J. I., Coleman, J. J., Coleves, A. D., Coltrera, M. D., Cooper, J., Costantino, P., Cotton, R. T., Couch, M., Crumley, R. L., Cullen, K., Cummings, C., Cunningham, M., Curley, S. A., D'Agostino, Jr, Davidson, B. J., Davidson, T. M., Davis, R. K., Davis, R. E., Day, T., Delclos, L., Otolaryngology / Head & Neck Surgery, AII - Cancer immunology, CCA - Cancer biology and immunology, and CCA - Imaging and biomarkers

Published
2001
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8. A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC).

Author

Ang, K. K., primary, Zhang, Q. E., additional, Rosenthal, D. I., additional, Nguyen-Tan, P., additional, Sherman, E. J., additional, Weber, R. S., additional, Galvin, J. M., additional, Schwartz, D. L., additional, El-Naggar, A. K., additional, Gillison, M. L., additional, Jordan, R., additional, List, M. A., additional, Konski, A. A., additional, Thorstad, W. L., additional, Trotti, A., additional, Beitler, J. J., additional, Garden, A. S., additional, Spanos, W. J., additional, Yom, S. S., additional, and Axelrod, R. S., additional

Published
2011
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10. Randomized trial of a short course of erlotinib 150 to 300 mg daily prior to surgery for squamous cell carcinomas of the head and neck (SCCHN) in current, former, and never smokers: Objective responses and clinical outcomes.

Author

William Junior, W. N., primary, Weber, R. S., additional, Lee, J. J., additional, Myers, J., additional, Ginsberg, L. E., additional, El-Naggar, A. K., additional, Sturgis, E. M., additional, Sabichi, A. L., additional, Kies, M. S., additional, Hanna, E. Y., additional, Hessel, A. C., additional, Lu, C., additional, Lai, S. Y., additional, Ayuste, R., additional, Lippman, S. M., additional, and Kim, E. S., additional

Published
2011
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22. Long-term results of Intergroup RTOG 91–11: A phase III trial to preserve the larynx—Induction cisplatin/5-FU and radiation therapy versus concurrent cisplatin and radiation therapy versus radiation therapy

Author

Forastiere, A. A., primary, Maor, M., additional, Weber, R. S., additional, Pajak, T., additional, Glisson, B., additional, Trotti, A., additional, Ridge, J., additional, Ensley, J., additional, Chao, C., additional, and Cooper, J., additional

Published
2006
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47. Detection of recurrent head and neck squamous cell carcinomas after radiation therapy with 2-18F-fluoro-2-deoxy-D-glucose positron emission tomography.

Author

Farber LA, Benard F, Machtay M, Smith RJ, Weber RS, Weinstein GS, Chalian AA, Alavi A, Rosenthal DI, Farber, L A, Benard, F, Machtay, M, Smith, R J, Weber, R S, Weinstein, G S, Chalian, A A, Alavi, A, and Rosenthal, D I

Abstract

Objectives/hypothesis: Fluorodeoxyglucose positron emission tomography (FDG-PET) has been proposed as a sensitive method to diagnose and stage various malignancies. We assessed the efficacy of FDG-PET imaging in distinguishing tumor persistence/recurrence from posttreatment changes following radiation therapy for squamous carcinomas of the head and neckStudy Design: Retrospective analysis of FDG-PET results compared with biopsy results or outcome, or both.Methods: Twenty-eight patients who had undergone radiation therapy with or without surgery for treatment of squamous cell carcinoma were studied with FDG-PET imaging. There was clinical suspicion for recurrence in each patient, but no obvious mass or lesion to biopsy was found on physical examination or anatomic imaging. The results of FDG-PET imaging were compared with those of biopsy or clinical follow-up of at least 6 months, or both.Results: FDG-PET imaging was positive in 13 patients, and the presence of active disease was confirmed in 12. Two thirds of the 12 received further cancer treatment. There were 15 negative FDG-PET images. Thirteen of these were confirmed true-negative images, but two studies were false-negative images. The sensitivity and specificity of FDG-PET were 86% and 93%, respectively, with positive and negative predictive values of 92% and 87%, respectively. The overall accuracy was 89%.Conclusion: FDG-PET imaging is a useful modality to distinguish tumor persistence/recurrence from radiation-induced tissue changes in the neck following treatment for head and neck cancer. FDG-PET can identify patients who may benefit from further treatment, and may lead to improved outcome for individual patients. [ABSTRACT FROM AUTHOR]

Published
1999

48. Nerve cell adhesion molecule expression in squamous cell carcinoma of the head and neck: a predictor of propensity toward perineural spread.

Author

McLaughlin RB Jr., Montone KT, Wall SJ, Chalian AA, Weinstein GS, Roberts SA, Wolf PF, Weber RS, McLaughlin, R B Jr, Montone, K T, Wall, S J, Chalian, A A, Weinstein, G S, Roberts, S A, Wolf, P F, and Weber, R S

Abstract

Objective: To evaluate head and neck squamous cell carcinomas (SCCAs) for the expression of nerve cell adhesion molecule (N-CAM). We propose that expression of N-CAM by tumor cells may be associated with perineural invasion in SCCA of the head and neck.Methods: Seventy-six archived specimens of histologically proven SCCA were analyzed by immunohistochemistry for the expression of N-CAM. Positive and negative controls were used to assess staining. Two sections of each specimen were reviewed for the presence of perineural invasion. A retrospective chart review was performed for each patient that corresponded to the above specimens.Results: Perineural invasion was present in 28 (37%) of the 76 patients evaluated for the expression of N-CAM. N-CAM expression was demonstrated in 38 (50%) of the 76 specimens. The incidence of N-CAM expression was significantly associated with perineural invasion (P = .002). There was no significant association between the presence of staining or the presence of perineural invasion and the incidence of locoregional recurrence, distant metastasis, or survival status; however, the mean follow-up was only 13.6 months (range, 1-49 mo).Conclusion: There is a positive correlation between the presence of N-CAM expression and perineural invasion in SCCA of the head and neck. The expression of this adhesion molecule by tumor cells may facilitate both homophilic cell-to-cell and heterophilic cell-to-substrate adhesion, thereby enabling the tumor cells to use the perineural tissues or neural cells, or both as a conduit for perineural spread. [ABSTRACT FROM AUTHOR]

Published
1999

49. Prognostic factors affecting outcome in lower gingival carcinoma.

Author

Overholt, S. Mark, Eicher, Susan A., Wolf, Pat, Weber, Randal S., Overholt, S M, Eicher, S A, Wolf, P, and Weber, R S

Abstract

Squamous cell carcinoma of the lower gingiva is a rare lesion that frequently invades the mandible. To determine the factors that affect local disease control and overall survival, a retrospective review of 155 previously untreated patients was performed. Primary lesions larger than 3 cm (P = .021) and persistently disease-positive surgical margins (P = .027) were found to be associated with decreased local control rates. Survival was adversely affected by advanced T stage (P = .001), positive initial and final surgical margins (P = .004), mandibular invasion (P = .014), and cervical metastases (P<.001). Extent of mandibular resection, tumor extension beyond the lower gingiva, recent dental extractions in the region of the primary, perineural invasion, and histologic grade did not affect local control or survival. Although lower gingival carcinoma tends to involve the mandible, our findings indicate that tumor size is more important than mandibular invasion in predicting local disease control. Larger tumors that have a greater propensity for local recurrence and poorer survival require a more extensive surgical resection. [ABSTRACT FROM AUTHOR]

Published
1996
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50. Wound prophylaxis with metronidazole in head and neck surgical oncology.

Author

Robbins, K. T., Byers, R. M., Fainstein, V., Schantz, S. P., Wolf, P., Cole, R., Guillamondegui, O. M., Weber, R. S., and Goepfert, H.

Abstract

Anaerobic organisms are thought to be an important source of wound infection in head and neck oncologic surgery. Antibiotic prophylaxis consisting of agents specific for anaerobes combined with broad-spectrum agents that provide coverage for other well-recognized pathogens should be an effective combination regimen for this group of patients. We conducted a prospective, randomized study comparing the efficacy of prophylaxis using combination of metronidazole and cefazolin-designated group A, to prophylaxis using cefazolin alone-group B, for patients undergoing oncologic procedures of the head and neck. The rate of wound infection in the cefazolin-metronidazole group (158 patients) was 9.5%, compared with 18.6% in the cefazolin group (172 patients) ( p=0.03). Patients undergoing clean procedures had a 4.9% infection rate overall, compared with 17.9% for clean-contaminated procedures, and 33.3% for contaminated procedures. The average length of hospitalization was 20.7 days for patients who developed infections, compared with 8.9 days for patients without infection. Anaerobic organisms were cultured in 12 of 26 patients, ten of whom did not receive metronidazole. The lower rate of wound infection among patients who received metronidazole suggests that anaerobic organisms are an important source of wound infection in head and neck oncologic surgery. Chemoprophylaxis for these patients should, therefore, include specific anaerobic coverage in addition to the broad-spectrum agents that cover the more familiar aerobic organisms. [ABSTRACT FROM AUTHOR]

Published
1988
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