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2. Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies

Author

Hasan Ali, Omar, Bomze, David, Risch, Lorenz, Brugger, Silvio D, Paprotny, Matthias, Weber, Myriam, Thiel, Sarah, Kern, Lukas, Albrich, Werner C, Kohler, Philipp, Kahlert, Christian R, Vernazza, Pietro, Bühler, Philipp K, Schüpbach, Reto A, Gómez-Mejia, Alejandro, Popa, Alexandra M, Bergthaler, Andreas, Penninger, Josef M, Flatz, Lukas, and University of Zurich

Subjects
610 Medicine & health, 10023 Institute of Intensive Care Medicine, COVID
Published
2021

3. Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies

Author

Hasan Ali, Omar, primary, Bomze, David, additional, Risch, Lorenz, additional, Brugger, Silvio D, additional, Paprotny, Matthias, additional, Weber, Myriam, additional, Thiel, Sarah, additional, Kern, Lukas, additional, Albrich, Werner C, additional, Kohler, Philipp, additional, Kahlert, Christian R, additional, Vernazza, Pietro, additional, Bühler, Philipp K, additional, Schüpbach, Reto A, additional, Gómez-Mejia, Alejandro, additional, Popa, Alexandra M, additional, Bergthaler, Andreas, additional, Penninger, Josef M, additional, and Flatz, Lukas, additional

Published
2021
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4. Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies

Author

Hasan Ali, Omar, Bomze, David, Risch, Lorenz, Brugger, Silvio D, Paprotny, Matthias, Weber, Myriam, Thiel, Sarah, Kern, Lukas, Albrich, Werner C, Kohler, Philipp, Kahlert, Christian R, Vernazza, Pietro, Bühler, Philipp K, Schüpbach, Reto A, Gómez-Mejia, Alejandro, Popa, Alexandra M, Bergthaler, Andreas, Penninger, Josef M, Flatz, Lukas, Hasan Ali, Omar, Bomze, David, Risch, Lorenz, Brugger, Silvio D, Paprotny, Matthias, Weber, Myriam, Thiel, Sarah, Kern, Lukas, Albrich, Werner C, Kohler, Philipp, Kahlert, Christian R, Vernazza, Pietro, Bühler, Philipp K, Schüpbach, Reto A, Gómez-Mejia, Alejandro, Popa, Alexandra M, Bergthaler, Andreas, Penninger, Josef M, and Flatz, Lukas

Abstract

BACKGROUND Severe coronavirus disease 2019 (COVID-19) frequently entails complications that bear similarities to autoimmune diseases. To date, there is little data on possible IgA-mediated autoimmune responses. Here, we aim to determine whether COVID-19 is associated with a vigorous total IgA response and if IgA antibodies are associated with complications of severe illness. Since thrombotic events are frequent in severe COVID-19 and resemble hypercoagulation of antiphospholipid syndrome (APS), our approach focused on antiphospholipid antibodies (aPL). METHODS In this retrospective cohort study clinical data and aPL from 64 patients with COVID-19 were compared from three independent tertiary hospitals (one in Liechtenstein, two in Switzerland). Samples were collected from April 9 th to May 1 st, 2020. RESULTS Clinical records of 64 patients with COVID-19 were reviewed and divided into a cohort with mild illness (mCOVID) (41%), a discovery cohort with severe illness (sdCOVID) (22%) and a confirmation cohort with severe illness (scCOVID) (38%). Total IgA, IgG and aPL were measured with clinical diagnostic kits. Severe illness was significantly associated with increased total IgA (sdCOVID, P=0.01; scCOVID, p-value<0.001), but not total IgG. Among aPL, both cohorts with severe illness significantly correlated with elevated anti-Cardiolipin IgA (sdCOVID and scCOVID, p-value<0.001), anti-Cardiolipin IgM (sdCOVID, P=0.003; scCOVID, P<0.001), and anti-Beta2 Glycoprotein-1 IgA (sdCOVID and scCOVID, P<0.001). Systemic lupus erythematosus was excluded from all patients as a potential confounder. CONCLUSIONS Higher total IgA and IgA-aPL were consistently associated with severe illness. These novel data strongly suggest that a vigorous antiviral IgA-response, possibly triggered in the bronchial mucosa, induces systemic autoimmunity.

Published
2021

6. Characteristics of Three Different Chemiluminescence Assays for Testing for SARS-CoV-2 Antibodies

Author

Weber, Myriam C., primary, Risch, Martin, additional, Thiel, Sarah L., additional, Grossmann, Kirsten, additional, Nigg, Susanne, additional, Wohlwend, Nadia, additional, Lung, Thomas, additional, Hillmann, Dorothea, additional, Ritzler, Michael, additional, Ferrara, Francesca, additional, Bigler, Susanna, additional, Egli, Konrad, additional, Bodmer, Thomas, additional, Imperiali, Mauro, additional, Salimi, Yacir, additional, Fleisch, Felix, additional, Cusini, Alexia, additional, Heer, Sonja, additional, Renz, Harald, additional, Paprotny, Matthias, additional, Kohler, Philipp, additional, Vernazza, Pietro, additional, Risch, Lorenz, additional, and Kahlert, Christian R., additional

Published
2021
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7. Characterization of a Pan-Immunoglobulin Assay Quantifying Antibodies Directed against the Receptor Binding Domain of the SARS-CoV-2 S1-Subunit of the Spike Protein: A Population-Based Study

Author

Schaffner, Anna, primary, Risch, Lorenz, additional, Aeschbacher, Stefanie, additional, Risch, Corina, additional, Weber, Myriam C., additional, Thiel, Sarah L., additional, Jüngert, Katharina, additional, Pichler, Michael, additional, Grossmann, Kirsten, additional, Wohlwend, Nadia, additional, Lung, Thomas, additional, Hillmann, Dorothea, additional, Bigler, Susanna, additional, Bodmer, Thomas, additional, Imperiali, Mauro, additional, Renz, Harald, additional, Kohler, Philipp, additional, Vernazza, Pietro, additional, Kahlert, Christian R., additional, Twerenbold, Raphael, additional, Paprotny, Matthias, additional, Conen, David, additional, and Risch, Martin, additional

Published
2020
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8. Sustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: a population-based study

Author

Schaffner, Anna, primary, Risch, Lorenz, additional, Weber, Myriam, additional, Thiel, Sarah, additional, Jüngert, Katharina, additional, Pichler, Michael, additional, Wohlwend, Nadia, additional, Lung, Thomas, additional, Ritzler, Michael, additional, Hillmann, Dorothea, additional, Copeland, Sandra, additional, Renz, Harald, additional, Paprotny, Matthias, additional, and Risch, Martin, additional

Published
2020
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9. Temporal Course of SARS-CoV-2 Antibody Positivity in Patients with COVID-19 following the First Clinical Presentation

Author

Risch, Martin, primary, Weber, Myriam, additional, Thiel, Sarah, additional, Grossmann, Kirsten, additional, Wohlwend, Nadia, additional, Lung, Thomas, additional, Hillmann, Dorothea, additional, Ritzler, Michael, additional, Ferrara, Francesca, additional, Bigler, Susanna, additional, Egli, Konrad, additional, Bodmer, Thomas, additional, Imperiali, Mauro, additional, Salimi, Yacir, additional, Fleisch, Felix, additional, Cusini, Alexia, additional, Renz, Harald, additional, Kohler, Philipp, additional, Vernazza, Pietro, additional, Kahlert, Christian R., additional, Paprotny, Matthias, additional, and Risch, Lorenz, additional

Published
2020
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10. Characteristics of three different chemiluminescence assays for testing for SARS-CoV-2 antibodies

Author

Weber, Myriam C., primary, Risch, Martin, additional, Thiel, Sarah L., additional, Grossmann, Kirsten, additional, Nigg, Susanne, additional, Wohlwend, Nadia, additional, Lung, Thomas, additional, Hillmann, Dorothea, additional, Ritzler, Michael, additional, Ferrara, Francesca, additional, Bigler, Susanna, additional, Egli, Konrad, additional, Bodmer, Thomas, additional, Imperiali, Mauro, additional, Salimi, Yacir, additional, Fleisch, Felix, additional, Cusini, Alexia, additional, Heer, Sonja, additional, Renz, Harald, additional, Paprotny, Matthias, additional, Kohler, Philipp, additional, Vernazza, Pietro, additional, Risch, Lorenz, additional, and Kahlert, Christian R., additional

Published
2020
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11. Flattening the curve in 52 days: characterisation of the COVID-19 pandemic in the Principality of Liechtenstein – an observational study

Author

Thiel, Sarah L., primary, Weber, Myriam C., additional, Risch, Lorenz, additional, Wohlwend, Nadia, additional, Lung, Thomas, additional, Hillmann, Dorothea, additional, Ritzler, Michael, additional, Risch, Martin, additional, Kohler, Philipp, additional, Vernazza, Pietro, additional, Kahlert, Christian R, additional, Fleisch, Felix, additional, Cusini, Alexia, additional, Karajan, Tomas V., additional, Copeland, Sandra, additional, and Paprotny, Matthias, additional

Published
2020
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12. Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies

Author

Hasan Ali, Omar, primary, Bomze, David, additional, Risch, Lorenz, additional, Brugger, Silvio D, additional, Paprotny, Matthias, additional, Weber, Myriam, additional, Thiel, Sarah, additional, Kern, Lukas, additional, Albrich, Werner C, additional, Kohler, Philipp, additional, Kahlert, Christian R, additional, Vernazza, Pietro, additional, Bühler, Philipp K, additional, Schüpbach, Reto A, additional, Gómez-Mejia, Alejandro, additional, Popa, Alexandra M, additional, Bergthaler, Andreas, additional, Penninger, Josef M, additional, and Flatz, Lukas, additional

Published
2020
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13. Frequency of serological non-responders and false-negative RT-PCR results in SARS-CoV-2 testing: a population-based study

Author

Baron, Rita Christiane, primary, Risch, Lorenz, additional, Weber, Myriam, additional, Thiel, Sarah, additional, Grossmann, Kirsten, additional, Wohlwend, Nadia, additional, Lung, Thomas, additional, Hillmann, Dorothea, additional, Ritzler, Michael, additional, Bigler, Susanna, additional, Egli, Konrad, additional, Ferrara, Francesca, additional, Bodmer, Thomas, additional, Imperiali, Mauro, additional, Heer, Sonja, additional, Renz, Harald, additional, Flatz, Lukas, additional, Kohler, Philipp, additional, Vernazza, Pietro, additional, Kahlert, Christian R., additional, Paprotny, Matthias, additional, and Risch, Martin, additional

Published
2020
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14. EDTA-Anticoagulated Whole Blood for SARS-CoV-2 Antibody Testing by Electrochemiluminescence Immunoassay (ECLIA) and Enzyme-Linked Immunosorbent Assay (ELISA)

Author

Kovac, Marc, primary, Risch, Lorenz, additional, Thiel, Sarah, additional, Weber, Myriam, additional, Grossmann, Kirsten, additional, Wohlwend, Nadja, additional, Lung, Thomas, additional, Hillmann, Dorothea, additional, Ritzler, Michael, additional, Bigler, Susanna, additional, Ferrara, Francesca, additional, Bodmer, Thomas, additional, Egli, Konrad, additional, Imperiali, Mauro, additional, Heer, Sonja, additional, Salimi, Yacir, additional, Renz, Harald, additional, Kohler, Philipp, additional, Vernazza, Pietro, additional, Kahlert, Christian R., additional, Paprotny, Matthias, additional, and Risch, Martin, additional

Published
2020
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15. Severe COVID-19 is associated with elevated serum IgA and antiphospholipid IgA-antibodies

Author

Ali, Omar Hasan, primary, Bomze, David, additional, Risch, Lorenz, additional, Brugger, Silvio D., additional, Paprotny, Matthias, additional, Weber, Myriam, additional, Thiel, Sarah, additional, Kern, Lukas, additional, Albrich, Werner C., additional, Kohler, Philipp, additional, Kahlert, Christian R., additional, Vernazza, Pietro, additional, Bühler, Philipp K., additional, Schüpbach, Reto A., additional, Gómez-Mejia, Alejandro, additional, Popa, Alexandra M., additional, Bergthaler, Andreas, additional, Penninger, Josef M., additional, and Flatz, Lukas, additional

Published
2020
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16. Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies.

Author

Ali, Omar Hasan, Bomze, David, Risch, Lorenz, Brugger, Silvio D, Paprotny, Matthias, Weber, Myriam, Thiel, Sarah, Kern, Lukas, Albrich, Werner C, Kohler, Philipp, Kahlert, Christian R, Vernazza, Pietro, Bühler, Philipp K, Schüpbach, Reto A, Gómez-Mejia, Alejandro, Popa, Alexandra M, Bergthaler, Andreas, Penninger, Josef M, and Flatz, Lukas

Subjects
AUTOANTIBODIES, DIAGNOSTIC reagents & test kits, RESPIRATORY mucosa, COVID-19, IMMUNOGLOBULINS, ANTIPHOSPHOLIPID syndrome, RETROSPECTIVE studies, TERTIARY care, COMPARATIVE studies, SEVERITY of illness index, MEDICAL records, DESCRIPTIVE statistics, STATISTICAL correlation, VIRAL antibodies, DATA analysis software, LONGITUDINAL method
Abstract

Background Severe coronavirus disease 2019 (COVID-19) frequently entails complications that bear similarities to autoimmune diseases. To date, there are little data on possible immunoglobulin (Ig) A–mediated autoimmune responses. Here, we aim to determine whether COVID-19 is associated with a vigorous total IgA response and whether IgA antibodies are associated with complications of severe illness. Since thrombotic events are frequent in severe COVID-19 and resemble hypercoagulation of antiphospholipid syndrome, our approach focused on antiphospholipid antibodies (aPL). Methods In this retrospective cohort study, clinical data and aPL from 64 patients with COVID-19 were compared from 3 independent tertiary hospitals (1 in Liechtenstein, 2 in Switzerland). Samples were collected from 9 April to 1 May 2020. Results Clinical records of 64 patients with COVID-19 were reviewed and divided into a cohort with mild illness (mCOVID; 41%), a discovery cohort with severe illness (sdCOVID; 22%) and a confirmation cohort with severe illness (scCOVID; 38%). Total IgA, IgG, and aPL were measured with clinical diagnostic kits. Severe illness was significantly associated with increased total IgA (sdCOVID, P =.01; scCOVID, P <.001), but not total IgG. Among aPL, both cohorts with severe illness significantly correlated with elevated anticardiolipin IgA (sdCOVID and scCOVID, P <.001), anticardiolipin IgM (sdCOVID, P =.003; scCOVID, P <.001), and anti–beta 2 glycoprotein-1 IgA (sdCOVID and scCOVID, P <.001). Systemic lupus erythematosus was excluded from all patients as a potential confounder. Conclusions Higher total IgA and IgA-aPL were consistently associated with severe illness. These novel data strongly suggest that a vigorous antiviral IgA response, possibly triggered in the bronchial mucosa, induces systemic autoimmunity. [ABSTRACT FROM AUTHOR]

Published
2021
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17. Sustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: a population-based study.

Author

Schaffner, Anna, Risch, Lorenz, Weber, Myriam, Thiel, Sarah, Jüngert, Katharina, Pichler, Michael, Wohlwend, Nadia, Lung, Thomas, Ritzler, Michael, Hillmann, Dorothea, Copeland, Sandra, Renz, Harald, Paprotny, Matthias, and Risch, Martin

Subjects
SARS-CoV-2, COVID-19, MEDICAL personnel, IMMUNOGLOBULINS, COVID-19 pandemic
Abstract

Keywords: antibody; coronavirus; COVID-19; kinetics; SARS-CoV-2 EN antibody coronavirus COVID-19 kinetics SARS-CoV-2 e49 e51 3 01/21/21 20210201 NES 210201 To the Editor, Antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 spike (S) protein are known to decay rapidly in patients with mild COVID-19 [[1]]. Table 1: Sensitivities of for SARS-CoV-2 N antigen total antibody, SARS-CoV-2 N-antigen IgG, SARS-CoV-2 S protein IgG, and SARS-CoV-2 S protein IgA at median 48 and 140 days after symptom onset is shown. IgA and IgG against the SARS-CoV-2 S-protein show a decrease; however, the total antibody levels directed against the SARS-CoV-2 N-antigen remain stable despite a decrease in SARS-CoV-2 N-antigen IgG. [Extracted from the article]

Published
2021
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21. Prenatal diagnosis of congenital upper limb differences: a current concept review.

Author

Alrabai, Hamza M., Farr, Alex, Bettelheim, Dieter, Weber, Myriam, and Farr, Sebastian

Subjects
ARM abnormalities, PRENATAL diagnosis, DIAGNOSTIC ultrasonic imaging, FETAL MRI, GENETIC disorders in children, PRENATAL genetic testing, DIAGNOSIS
Abstract

Congenital upper limb differences are frequently associated with complex syndromes. Ultrasonography is considered as the first-line diagnostic modality, and fetal MRI can be useful to further evaluate ill-defined areas. Genetic and non-invasive prenatal testing help to identify the underlying genetic disorder. The diagnostic assessment is a multidisciplinary task that should involve early prenatal consultations with specialists involved in case management and treatment planning. Obstetricians, geneticists, radiologists, psychologists and dedicated surgeons are needed to provide good parental education, prenatal and postnatal care, and successful outcomes. The purpose of this review is to provide an overview of the clinicopathologic background, current diagnostic and imaging procedures in affected fetuses. [ABSTRACT FROM AUTHOR]

Published
2017
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22. Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies.

Author

Ali, Omar Hasan, Bomze, David, Risch, Lorenz, Brugger, Silvio D, Paprotny, Matthias, Weber, Myriam, Thiel, Sarah, Kern, Lukas, Albrich, Werner C, Kohler, Philipp, Kahlert, Christian R, Vernazza, Pietro, Bühler, Philipp K, Schüpbach, Reto A, Gómez-Mejia, Alejandro, Popa, Alexandra M, Bergthaler, Andreas, Penninger, Josef M, and Flatz, Lukas

Subjects
COVID-19, IMMUNOGLOBULINS
Abstract

The article presents a correction to article "Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies" published in a previous issue of the periodical.

Published
2021
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23. Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies.

Author

Hasan Ali O, Bomze D, Risch L, Brugger SD, Paprotny M, Weber M, Thiel S, Kern L, Albrich WC, Kohler P, Kahlert CR, Vernazza P, Bühler PK, Schüpbach RA, Gómez-Mejia A, Popa AM, Bergthaler A, Penninger JM, and Flatz L

Subjects
Antibodies, Antiphospholipid, Humans, Immunoglobulin A, Retrospective Studies, SARS-CoV-2, COVID-19
Abstract

Background: Severe coronavirus disease 2019 (COVID-19) frequently entails complications that bear similarities to autoimmune diseases. To date, there are little data on possible immunoglobulin (Ig) A-mediated autoimmune responses. Here, we aim to determine whether COVID-19 is associated with a vigorous total IgA response and whether IgA antibodies are associated with complications of severe illness. Since thrombotic events are frequent in severe COVID-19 and resemble hypercoagulation of antiphospholipid syndrome, our approach focused on antiphospholipid antibodies (aPL)., Methods: In this retrospective cohort study, clinical data and aPL from 64 patients with COVID-19 were compared from 3 independent tertiary hospitals (1 in Liechtenstein, 2 in Switzerland). Samples were collected from 9 April to 1 May 2020., Results: Clinical records of 64 patients with COVID-19 were reviewed and divided into a cohort with mild illness (mCOVID; 41%), a discovery cohort with severe illness (sdCOVID; 22%) and a confirmation cohort with severe illness (scCOVID; 38%). Total IgA, IgG, and aPL were measured with clinical diagnostic kits. Severe illness was significantly associated with increased total IgA (sdCOVID, P = .01; scCOVID, P < .001), but not total IgG. Among aPL, both cohorts with severe illness significantly correlated with elevated anticardiolipin IgA (sdCOVID and scCOVID, P < .001), anticardiolipin IgM (sdCOVID, P = .003; scCOVID, P< .001), and anti-beta 2 glycoprotein-1 IgA (sdCOVID and scCOVID, P< .001). Systemic lupus erythematosus was excluded from all patients as a potential confounder., Conclusions: Higher total IgA and IgA-aPL were consistently associated with severe illness. These novel data strongly suggest that a vigorous antiviral IgA response, possibly triggered in the bronchial mucosa, induces systemic autoimmunity., (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)

Published
2021
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