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Your search keyword '"Weber, Frederike"' showing total 8 results
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8 results on '"Weber, Frederike"'

1. Iatrogenic botulism after intragastric botulinum neurotoxin injections – a major outbreak

Author

Goerttler, Tsepo, Dorner, Martin B., van der Linden, Christina, Kienitz, Ricardo, Petrik, Stephan, Blechinger, Stephan, Spickschen, Jonah, Betz, Iris R., Hinrichs, Carl, Steindl, David, Weber, Frederike, Musacchio, Thomas, Wunderlich, Gilbert, Rueger, Maria Adele, Barbe, Michael T., Dafsari, Haidar, Demir, Seda, Lapa, Sriramya, Zeiner, Pia S., Strzelczyk, Adam, Tinnemann, Peter, Kleine, Christian, Totzeck, Andreas, Klebe, Stephan, Mikolajewska, Agata, Dorner, Brigitte G., Fertl, Elisabeth, Grefkes-Hermann, Christian, Fink, Gereon, Kleinschnitz, Christoph, and Hagenacker, Tim

Published
2024
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7. Von Automatisierung bis Wirtschaftsingenieurwesen: Trends und offene Fragen im Ausbildungs- und Berufsfeld 'Technik'

Author

Senn, Claudia and Weber, Frederike

Subjects
Anforderungsprofil, ddc:330, Technische Berufe, Österreich
Abstract

Im Zuge berufskundlicher Recherchen im Auftrag des AMS Österreich, Abteilung Arbeitsmarktforschung und Berufsinformation, analysierte die Prospect Unternehmensberatung im Jahr 2007 einige Trends wie auch offene Fragen zum Ausbildungs- und Berufsfeld 'Technik'.

Published
2008

8. From the Total Synthesis of Semi-Viriditoxin, Semi-Viriditoxic Acid and Dimeric Naphthopyranones to their Biological Activities in Burkitt B Cell Lymphoma.

Author

Weber F, Weber A, Schmitt L, Lechtenberg I, Greb J, Henßen B, Wesselborg S, and Pietruszka J

Subjects
Structure-Activity Relationship, Cell Line, Tumor, Humans, Stereoisomerism, Apoptosis drug effects, Lactones chemistry, Lactones pharmacology, Lactones chemical synthesis, Cyclization, Antineoplastic Agents pharmacology, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Burkitt Lymphoma drug therapy, Burkitt Lymphoma pathology
Abstract

Dimeric naphthopyranones are known to be biologically active, however, for the corresponding monomeric naphthopyranones this information is still elusive. Here the first enantioselective total synthesis of semi-viriditoxic acid as well as the synthesis of semi-viriditoxin and derivatives is reported. The key intermediate in the synthesis of naphthopyranones is an α,β-unsaturated δ-lactone, which we synthesized in two different ways (Ghosez-cyclization and Grubbs ring-closing metathesis), while the domino-Michael-Dieckmann reaction of the α,β-unsaturated δ-lactone with an orsellinic acid derivative is the key reaction. A structure-activity relationship study was performed measuring the cytotoxicity in Burkitt B lymphoma cells (Ramos). The dimeric structure was found to be crucial for biological activity: Only the dimeric naphthopyranones showed cytotoxic and apoptotic activity, whereas the monomers did not display any activity at all., (© 2024 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)

Published
2024
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