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3 results on '"Weaver, Madison L."'

1. Low Diversity and Instability of the Sinus Microbiota over Time in Adults with Cystic Fibrosis

Author

Armbruster, Catherine R., primary, Li, Kelvin, additional, Kiedrowski, Megan R., additional, Zemke, Anna C., additional, Melvin, Jeffrey A., additional, Moore, John, additional, Atteih, Samar, additional, Fitch, Adam C., additional, DuPont, Matthew, additional, Manko, Christopher D., additional, Weaver, Madison L., additional, Gaston, Jordon R., additional, Alcorn, John F., additional, Morris, Alison, additional, Methé, Barbara A., additional, Lee, Stella E., additional, and Bomberger, Jennifer M., additional

Published
2022
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2. Adaptation and genomic erosion in fragmented Pseudomonas aeruginosa populations in the sinuses of people with cystic fibrosis

Author

Armbruster, Catherine R., primary, Marshall, Christopher W., additional, Garber, Arkadiy I., additional, Melvin, Jeffrey A., additional, Zemke, Anna C., additional, Moore, John, additional, Zamora, Paula F., additional, Li, Kelvin, additional, Fritz, Ian L., additional, Manko, Christopher D., additional, Weaver, Madison L., additional, Gaston, Jordan R., additional, Morris, Alison, additional, Methé, Barbara, additional, DePas, William H., additional, Lee, Stella E., additional, Cooper, Vaughn S., additional, and Bomberger, Jennifer M., additional

Published
2021
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3. Adaptation and genomic erosion in fragmented Pseudomonas aeruginosapopulations in the sinuses of people with cystic fibrosis

Author

Armbruster, Catherine R., Marshall, Christopher W., Garber, Arkadiy I., Melvin, Jeffrey A., Zemke, Anna C., Moore, John, Zamora, Paula F., Li, Kelvin, Fritz, Ian L., Manko, Christopher D., Weaver, Madison L., Gaston, Jordan R., Morris, Alison, Methé, Barbara, DePas, William H., Lee, Stella E., Cooper, Vaughn S., and Bomberger, Jennifer M.

Abstract

Pseudomonas aeruginosanotoriously adapts to the airways of people with cystic fibrosis (CF), yet how infection-site biogeography and associated evolutionary processes vary as lifelong infections progress remains unclear. Here we test the hypothesis that early adaptations promoting aggregation influence evolutionary-genetic trajectories by examining longitudinal P. aeruginosafrom the sinuses of six adults with CF.Highly host-adapted lineages harbored mutator genotypes displaying signatures of early genome degradation associated with recent host restriction. Using an advanced imaging technique (MiPACT-HCR [microbial identification after passive clarity technique]), we find population structure tracks with genome degradation, with the most host-adapted, genome-degraded P. aeruginosa(the mutators) residing in small, sparse aggregates. We propose that following initial adaptive evolution in larger populations under strong selection for aggregation, P. aeruginosapersists in small, fragmented populations that experience stronger effects of genetic drift. These conditions enrich for mutators and promote degenerative genome evolution. Our findings underscore the importance of infection-site biogeography to pathogen evolution.

Published
2021
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