496 results on '"Weale, Michael E."'
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2. Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information.
3. Abstract 17308: Patient and Primary Care Provider Experiences From an Implementation Study of a Risk Prediction Tool Integrating a Polygenic Risk Score and the QRISK2 Cardiovascular Risk Calculator
4. Polygenic risk score adds to a clinical risk score in the prediction of cardiovascular disease in a clinical setting
5. A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release.
6. Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries
7. A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting
8. The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population
9. Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study
10. Genetic Signatures Reveal High-Altitude Adaptation in a Set of Ethiopian Populations
11. Anti-Apostatic Selection by Wild Birds on Quasi-Natural Morphs of the Land Snail Cepaea hortensis: A Generalised Linear Mixed Models Approach
12. Little genetic differentiation as assessed by uniparental markers in the presence of substantial language variation in peoples of the Cross River region of Nigeria
13. Inferences from DNA Data: Population Histories, Evolutionary Processes and Forensic Match Probabilities
14. The Influence of Density on Frequency-Dependent Food Selection: A Comparison of Four Experiments with Wild Birds
15. The Influence of Density on Frequency-Dependent Selection by Wild Birds Feeding on Artificial Prey
16. Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture
17. Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture
18. Systematic assessment of the influence of complement gene polymorphisms on kidney transplant outcome
19. Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals: Genomic Precision Medicine May Dispense With Ethnicity
20. Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis
21. Analysis of subcellular RNA fractions demonstrates significant genetic regulation of gene expression in human brain post-transcriptionally.
22. Phenome-wide association studies across large population cohorts support drug target validation
23. Insights into TREM2 biology by network analysis of human brain gene expression data
24. Analysis of nucleus and cytoplasm-specific RNA fractions demonstrates that a significant proportion of the genetic regulation of gene expression across the human brain occurs post-transcriptionally
25. Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders
26. Delta-Centralization Fails to Control for Population Stratification in Genetic Association Studies
27. Sex‐Specific Genetic Data Support One of Two Alternative Versions of the Foundation of the Ruling Dynasty of the Nso′ in Cameroon
28. A survey of genetic simulation software for population and epidemiological studies
29. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
30. Network-Informed Gene Ranking Tackles Genetic Heterogeneity in Exome-Sequencing Studies of Monogenic Disease
31. Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
32. A survey of current software for haplotype phase inference
33. Abstract 11316: Analytical Validation for an Integrated Risk Tool for Cardiovascular Disease Combining Conventional Risk Factors and Polygenic Risk Inferred from Snp Array and Low-Pass Whole Genome Sequencing
34. Abstract 12101: Clinical Implications of Integrating Polygenic Risk Into Established Cardiovascular Disease Risk Scores
35. Recursive splicing in long vertebrate genes
36. Common genetic variants influence human subcortical brain structures
37. Genomics software: The view from 10,000 feet
38. Multiple Rare Variants as a Cause of a Common Phenotype: Several Different Lactase Persistence Associated Alleles in a Single Ethnic Group
39. A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis
40. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
41. Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction
42. A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?
43. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study
44. Evolution of a length polymorphism in the human PER3 gene, a component of the circadian system
45. The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans
46. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A
47. The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinsonʼs disease with a sexual dimorphism
48. Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies
49. Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci
50. Multiple origins of Ashkenazi Levites: Y chromosome evidence for both Near Eastern and European ancestries
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