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8. ManyBabies 5: A large-scale investigation of the proposed shift from familiarity preference to novelty preference in infant looking time

Author

Kosie, J., Zettersten, M., Abu-Zhaya, R., Amso, D., Babineau, M., Baumgartne, H., Bazhydai, r., Belia, M., Benavides, S., Bergmann, C., Berteletti, I., Black, A., Borges, P., Borovsky, A., Byers-Heinlein, K., Cabrera, L., Calignano, G., Cao, A., Cox, C., Ben, R., Dautriche, I., DeBolt, M., Exner, A., Fisher-Thompson, D., Frank, M., Gönül, G., Gonzalez-Gomez, N., Grosse Wiesmann, C., Hamlin, K., Havron, N., Hochmann, J., Hoehl, S., Houston-Price, C., Kachergis, G., Kaldy, Z., Kingo, O., Ko, E., Kong, S., Krøjgaard, P., Liu, S., Lu, H., Maganti, M., Mather, E., Mayor, J., McMillan, B., Molnar, M., Moreau, D., Moriguchi, Y., Moulson, M., Mueller, J., Oakes, L., Peperkamp, S., Peykarjou, S., Taveira, M., Raz, P., Requena, P., Rocha-Hidalgo, J., Saffran, J., Schaetz, C., Schuwerk, T., Shinskey, J., Simpson, E., Singh, L., Smolak, E., Soderstrom, M., Sonne, T., Ssemata, A., Visser, I., Holzen, K., Waxman, S., Westermann, G., White, K., Woodruff, K., Katharina, C., Henriette, Z., Lucie, Z., Zorana, Z., Casey, Z., and Lew-Williams

Abstract

Much of our basic understanding of cognitive and social processes in infancy relies on measures of looking time, and specifically on infants’ visual preference for a novel or familiar stimulus. However, despite being the foundation of many behavioral tasks in infant research, the determinants of infants’ visual preferences are poorly understood, and differences in the expression of preferences can be difficult to interpret. In this large-scale study, we test predictions from the Hunter and Ames model of infants' visual preferences. We investigate the effects of three factors predicted by this model to determine infants’ preference for novel versus familiar stimuli: age, stimulus familiarity, and stimulus complexity. Drawing from a large and diverse sample of infant participants (N = XX), this study will provide crucial empirical evidence for a robust and generalizable model of infant visual preferences, leading to a more solid theoretical foundation for understanding the mechanisms that underlie infants’ responses in common behavioral paradigms. Moreover, our findings will guide future studies that rely on infants' visual preferences to measure cognitive and social processes.

Published
2023

14. THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Overview

Author

Alexander, Stephen PH, Kelly, Eamonn, Marrion, Neil, Peters, John A, Benson, Helen E, Faccenda, Elena, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Buneman, Peter O, Catterall, William A, Cidlowski, John A, Davenport, Anthony P, Fabbro, Doriano, Fan, Grace, McGrath, John C, Spedding, Michael, Davies, Jamie A, Aldrich, R, Attali, B, Bäck, M l, Barnes, N M, Bathgate, R, Beart, P M, Becirovic, E, Biel, M, Birdsall, N J, Boison, D, Bräuner-Osborne, H, Bröer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, S L, Chandy, K G, Chiang, N, Christakos, S, Christopoulos, A, Chun, J J, Chung, J-J, Clapham, D E, Connor, M A, Coons, L, Cox, H M, Dautzenberg, F M, Dent, G, Douglas, S D, Dubocovich, M L, Edwards, D P, Farndale, R, Fong, T M, Forrest, D, Fowler, C J, Fuller, P, Gainetdinov, R R, Gershengorn, M A, Goldin, A, Goldstein, S AN, Grimm, S L, Grissmer, S, Gundlach, A L, Hagenbuch, B, Hammond, J R, Hancox, J C, Hartig, S, Hauger, R L, Hay, D L, Hébert, T, Hollenberg, A N, Holliday, N D, Hoyer, D, Ijzerman, A P, Inui, K I, Ishii, S, Jacobson, K A, Jan, L Y, Jarvis, G E, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, L K, Kanai, Y, Kang, H S, Karnik, S, Kerr, I D, Korach, K S, Lange, C A, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, S J, Macewan, D, Maguire, J J, May, J M, Mazella, J, Mcardle, C A, Mcdonnell, D P, Michel, M C, Miller, L J, Mitolo, V, Monie, T, Monk, P N, Mouillac, B, Murphy, P M, Nahon, J-L, Nerbonne, J, Nichols, C G, Norel, X, Oakley, R, Offermanns, S, Palmer, L G, Panaro, M A, Perez-Reyes, E, Pertwee, R G, Pike, J W, Pin, J P, Pintor, S, Plant, L D, Poyner, D R, Prossnitz, E R, Pyne, S, Ren, D, Richer, J K, Rondard, P, Ross, R A, Sackin, H, Safi, R, Sanguinetti, M C, Sartorius, C A, Segaloff, D L, Sladek, F M, Stewart, G, Stoddart, L A, Striessnig, J, Summers, R J, Takeda, Y, Tetel, M, Toll, L, Trimmer, J S, Tsai, M-J, Tsai, S Y, Tucker, S, Usdin, T B, Vilargada, J-P, Vore, M, Ward, D T, Waxman, S G, Webb, P, Wei, A D, Weigel, N, Willars, G B, Winrow, C, Wong, S S, Wulff, H, Ye, R D, Young, M, and Zajac, J-M

Published
2015
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17. Clinical outcomes in COVID-19 patients with in-hospital cardiac arrest – an insight from multi-centre data

Author

Mughal, M, primary, Kaur, I, additional, Waxman, S, additional, Gandhi, H, additional, Kakadia, M, additional, Khakwani, Z, additional, Okoh, A, additional, Shah, K, additional, Obaid, A, additional, Sirpal, V, additional, Azad, S, additional, Jaffery, A, additional, Jagdey, H, additional, Tawfik, I, additional, and Alam, M, additional

Published
2021
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31. Quantifying sources of variability in infancy research using the Infant-Directed-Speech preference

Author

ManyBabies Consortium, T, Frank, M, Jane Alcock, K, Arias-Trejo, N, Aschersleben, G, Baldwin, D, Barbu, S, Bergelson, E, Bergmann, C, Black, A, Blything, R, Böhland, M, Bolitho, P, Borovsky, A, Brady, S, Braun, B, Brown, A, Byers-Heinlein, K, Campbell, L, Cashon, C, Choi, M, Christodoulou, J, Cirelli, L, Conte, S, Cordes, S, Cox, C, Cristia, A, Cusack, R, Davies, C, de Klerk, M, Delle Luche, C, de Ruiter, L, Dinakar, D, Dixon, K, Durier, V, Durrant, S, Fennell, C, Ferguson, B, Ferry, A, Fikkert, P, Flanagan, T, Floccia, C, Foley, M, Fritzsche, T, Frost, R, Gampe, A, Gervain, J, Gonzalez-Gomez, N, Gupta, A, Hahn, L, Kiley Hamlin, J, Hannon, E, Havron, N, Hay, J, Hernik, M, Höhle, B, Houston, D, Howard, L, Ishikawa, M, Itakura, S, Jackson, I, Jakobsen, K, Jarto, M, Johnson, S, Junge, C, Karadag, D, Kartushina, N, Kellier, D, Keren-Portnoy, T, Klassen, K, Kline, M, Ko, E, Kominsky, J, Kosie, J, Kragness, H, Krieger, A, Krieger, F, Lany, J, Lazo, R, Lee, M, Leservoisier, C, Levelt, C, Lew-Williams, C, Lippold, M, Liszkowski, U, Liu, L, Luke, S, Lundwall, R, MACCHI CASSIA, V, Mani, N, Marino, C, Martin, A, Mastroberardino, M, Mateu, V, Mayor, J, Menn, K, Michel, C, Moriguchi, Y, Morris, B, Nave, K, Nazzi, T, Noble, C, Novack, M, Olesen, N, John Orena, A, Ota, M, Panneton, R, Parvanezadeh Esfahani, S, Paulus, M, Pletti, C, Polka, L, Potter, C, Rabagliati, H, Ramachandran, S, Rennels, J, Reynolds, G, Roth, K, Rothwell, C, Rubez, D, Ryjova, Y, Saffran, J, Sato, A, Savelkouls, S, Schachner, A, Schafer, G, Schreiner, M, Seidl, A, Shukla, M, Simpson, E, Singh, L, Skarabela, B, Soley, G, Sundara, M, Theakston, A, Thompson, A, Trainor, L, Trehub, S, Trøan, A, Sin-Mei Tsui, A, Twomey, K, Von Holzen, K, Wang, Y, Waxman, S, Werker, J, Wermelinger, S, Woolard, A, Yurovsky, D, Zahner, K, Zettersten, M, Soderstrom, M, The ManyBabies Consortium, Michael C. Frank, Katherine Jane Alcock, Natalia Arias-Trejo, Gisa Aschersleben, Dare Baldwin, Stéphanie Barbu, Elika Bergelson, Christina Bergmann, Alexis K. Black, Ryan Blything, Maximilian P. Böhland, Petra Bolitho, Arielle Borovsky, Shannon M. Brady, Bettina Braun, Anna Brown, Krista Byers-Heinlein, Linda E. Campbell, Cara Cashon, Mihye Choi, Joan Christodoulou, Laura K. Cirelli, Stefania Conte, Sara Cordes, Christopher Cox, Alejandrina Cristia, Rhodri Cusack, Catherine Davies, Maartje de Klerk, Claire Delle Luche, Laura de Ruiter, Dhanya Dinakar, Kate C. Dixon, Virginie Durier, Samantha Durrant, Christopher Fennell, Brock Ferguson, Alissa Ferry, Paula Fikkert, Teresa Flanagan, Caroline Floccia, Megan Foley, Tom Fritzsche, Rebecca L. A. Frost, Anja Gampe, Judit Gervain, Nayeli Gonzalez-Gomez, Anna Gupta, Laura E. Hahn, J. Kiley Hamlin, Erin E. Hannon, Naomi Havron, Jessica Hay, Mikołaj Hernik, Barbara Höhle, Derek M. Houston, Lauren H. Howard, Mitsuhiko Ishikawa, Shoji Itakura, Iain Jackson, Krisztina V. Jakobsen, Marianna Jarto, Scott P. Johnson, Caroline Junge, Didar Karadag, Natalia Kartushina, Danielle J. Kellier, Tamar Keren-Portnoy, Kelsey Klassen, Melissa Kline, Eon-Suk Ko, Jonathan F. Kominsky, Jessica E. Kosie, Haley E. Kragness, Andrea A. R. Krieger, Florian Krieger, Jill Lany, Roberto J. Lazo, Michelle Lee, Chloé Leservoisier, Claartje Levelt, Casey Lew-Williams, Matthias Lippold, Ulf Liszkowski, Liquan Liu, Steven G. Luke, Rebecca A. Lundwall, Viola Macchi Cassia, Nivedita Mani, Caterina Marino, Alia Martin, Meghan Mastroberardino, Victoria Mateu, Julien Mayor, Katharina Menn, Christine Michel, Yusuke Moriguchi, Benjamin Morris, Karli M. Nave, Thierry Nazzi, Claire Noble, Miriam A. Novack, Nonah M. Olesen, Adriel John Orena, Mitsuhiko Ota, Robin Panneton, Sara Parvanezadeh Esfahani, Markus Paulus, Carolina Pletti, Linda Polka, Christine Potter, Hugh Rabagliati, Shruthilaya Ramachandran, Jennifer L. Rennels, Greg D. Reynolds, Kelly C. Roth, Charlotte Rothwell, Doroteja Rubez, Yana Ryjova, Jenny Saffran, Ayumi Sato, Sophie Savelkouls, Adena Schachner, Graham Schafer, Melanie S. Schreiner, Amanda Seidl, Mohinish Shukla, Elizabeth A. Simpson, Leher Singh, Barbora Skarabela, Gaye Soley, Megha Sundara, Anna Theakston, Abbie Thompson, Laurel J. Trainor, Sandra E. Trehub, Anna S. Trøan, Angeline Sin-Mei Tsui, Katherine Twomey, Katie Von Holzen, Yuanyuan Wang, Sandra Waxman, Janet F. Werker, Stephanie Wermelinger, Alix Woolard, Daniel Yurovsky, Katharina Zahner, Martin Zettersten, Melanie Soderstrom, ManyBabies Consortium, T, Frank, M, Jane Alcock, K, Arias-Trejo, N, Aschersleben, G, Baldwin, D, Barbu, S, Bergelson, E, Bergmann, C, Black, A, Blything, R, Böhland, M, Bolitho, P, Borovsky, A, Brady, S, Braun, B, Brown, A, Byers-Heinlein, K, Campbell, L, Cashon, C, Choi, M, Christodoulou, J, Cirelli, L, Conte, S, Cordes, S, Cox, C, Cristia, A, Cusack, R, Davies, C, de Klerk, M, Delle Luche, C, de Ruiter, L, Dinakar, D, Dixon, K, Durier, V, Durrant, S, Fennell, C, Ferguson, B, Ferry, A, Fikkert, P, Flanagan, T, Floccia, C, Foley, M, Fritzsche, T, Frost, R, Gampe, A, Gervain, J, Gonzalez-Gomez, N, Gupta, A, Hahn, L, Kiley Hamlin, J, Hannon, E, Havron, N, Hay, J, Hernik, M, Höhle, B, Houston, D, Howard, L, Ishikawa, M, Itakura, S, Jackson, I, Jakobsen, K, Jarto, M, Johnson, S, Junge, C, Karadag, D, Kartushina, N, Kellier, D, Keren-Portnoy, T, Klassen, K, Kline, M, Ko, E, Kominsky, J, Kosie, J, Kragness, H, Krieger, A, Krieger, F, Lany, J, Lazo, R, Lee, M, Leservoisier, C, Levelt, C, Lew-Williams, C, Lippold, M, Liszkowski, U, Liu, L, Luke, S, Lundwall, R, MACCHI CASSIA, V, Mani, N, Marino, C, Martin, A, Mastroberardino, M, Mateu, V, Mayor, J, Menn, K, Michel, C, Moriguchi, Y, Morris, B, Nave, K, Nazzi, T, Noble, C, Novack, M, Olesen, N, John Orena, A, Ota, M, Panneton, R, Parvanezadeh Esfahani, S, Paulus, M, Pletti, C, Polka, L, Potter, C, Rabagliati, H, Ramachandran, S, Rennels, J, Reynolds, G, Roth, K, Rothwell, C, Rubez, D, Ryjova, Y, Saffran, J, Sato, A, Savelkouls, S, Schachner, A, Schafer, G, Schreiner, M, Seidl, A, Shukla, M, Simpson, E, Singh, L, Skarabela, B, Soley, G, Sundara, M, Theakston, A, Thompson, A, Trainor, L, Trehub, S, Trøan, A, Sin-Mei Tsui, A, Twomey, K, Von Holzen, K, Wang, Y, Waxman, S, Werker, J, Wermelinger, S, Woolard, A, Yurovsky, D, Zahner, K, Zettersten, M, Soderstrom, M, The ManyBabies Consortium, Michael C. Frank, Katherine Jane Alcock, Natalia Arias-Trejo, Gisa Aschersleben, Dare Baldwin, Stéphanie Barbu, Elika Bergelson, Christina Bergmann, Alexis K. Black, Ryan Blything, Maximilian P. Böhland, Petra Bolitho, Arielle Borovsky, Shannon M. Brady, Bettina Braun, Anna Brown, Krista Byers-Heinlein, Linda E. Campbell, Cara Cashon, Mihye Choi, Joan Christodoulou, Laura K. Cirelli, Stefania Conte, Sara Cordes, Christopher Cox, Alejandrina Cristia, Rhodri Cusack, Catherine Davies, Maartje de Klerk, Claire Delle Luche, Laura de Ruiter, Dhanya Dinakar, Kate C. Dixon, Virginie Durier, Samantha Durrant, Christopher Fennell, Brock Ferguson, Alissa Ferry, Paula Fikkert, Teresa Flanagan, Caroline Floccia, Megan Foley, Tom Fritzsche, Rebecca L. A. Frost, Anja Gampe, Judit Gervain, Nayeli Gonzalez-Gomez, Anna Gupta, Laura E. Hahn, J. Kiley Hamlin, Erin E. Hannon, Naomi Havron, Jessica Hay, Mikołaj Hernik, Barbara Höhle, Derek M. Houston, Lauren H. Howard, Mitsuhiko Ishikawa, Shoji Itakura, Iain Jackson, Krisztina V. Jakobsen, Marianna Jarto, Scott P. Johnson, Caroline Junge, Didar Karadag, Natalia Kartushina, Danielle J. Kellier, Tamar Keren-Portnoy, Kelsey Klassen, Melissa Kline, Eon-Suk Ko, Jonathan F. Kominsky, Jessica E. Kosie, Haley E. Kragness, Andrea A. R. Krieger, Florian Krieger, Jill Lany, Roberto J. Lazo, Michelle Lee, Chloé Leservoisier, Claartje Levelt, Casey Lew-Williams, Matthias Lippold, Ulf Liszkowski, Liquan Liu, Steven G. Luke, Rebecca A. Lundwall, Viola Macchi Cassia, Nivedita Mani, Caterina Marino, Alia Martin, Meghan Mastroberardino, Victoria Mateu, Julien Mayor, Katharina Menn, Christine Michel, Yusuke Moriguchi, Benjamin Morris, Karli M. Nave, Thierry Nazzi, Claire Noble, Miriam A. Novack, Nonah M. Olesen, Adriel John Orena, Mitsuhiko Ota, Robin Panneton, Sara Parvanezadeh Esfahani, Markus Paulus, Carolina Pletti, Linda Polka, Christine Potter, Hugh Rabagliati, Shruthilaya Ramachandran, Jennifer L. Rennels, Greg D. Reynolds, Kelly C. Roth, Charlotte Rothwell, Doroteja Rubez, Yana Ryjova, Jenny Saffran, Ayumi Sato, Sophie Savelkouls, Adena Schachner, Graham Schafer, Melanie S. Schreiner, Amanda Seidl, Mohinish Shukla, Elizabeth A. Simpson, Leher Singh, Barbora Skarabela, Gaye Soley, Megha Sundara, Anna Theakston, Abbie Thompson, Laurel J. Trainor, Sandra E. Trehub, Anna S. Trøan, Angeline Sin-Mei Tsui, Katherine Twomey, Katie Von Holzen, Yuanyuan Wang, Sandra Waxman, Janet F. Werker, Stephanie Wermelinger, Alix Woolard, Daniel Yurovsky, Katharina Zahner, Martin Zettersten, and Melanie Soderstrom

Abstract

Psychological scientists have become increasingly concerned with issues related to methodology and replicability, and infancy researchers in particular face specific challenges related to replicability: For example, high-powered studies are difficult to conduct, testing conditions vary across labs, and different labs have access to different infant populations. Addressing these concerns, we report on a large-scale, multisite study aimed at (a) assessing the overall replicability of a single theoretically important phenomenon and (b) examining methodological, cultural, and developmental moderators. We focus on infants’ preference for infant-directed speech (IDS) over adult-directed speech (ADS). Stimuli of mothers speaking to their infants and to an adult in North American English were created using seminaturalistic laboratory-based audio recordings. Infants’ relative preference for IDS and ADS was assessed across 67 laboratories in North America, Europe, Australia, and Asia using the three common methods for measuring infants’ discrimination (head-turn preference, central fixation, and eye tracking). The overall meta-analytic effect size (Cohen’s d) was 0.35, 95% confidence interval = [0.29, 0.42], which was reliably above zero but smaller than the meta-analytic mean computed from previous literature (0.67). The IDS preference was significantly stronger in older children, in those children for whom the stimuli matched their native language and dialect, and in data from labs using the head-turn preference procedure. Together, these findings replicate the IDS preference but suggest that its magnitude is modulated by development, native-language experience, and testing procedure.

Published
2020

40. Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha

Author

Cheng, G.-X., Zhu, X.-H., Men, X.-Q., Wang, L., Huang, Q.-H., Jin, X.L., Xiong, S.-M., Zhu, J., Guo, W.-M., Chen, J.-Q., Xu, S.-F., Chan, L.-C., Waxman, S., Zelent, A., Chen, G.-Q., Dong, S., Liu, J.-X., and Chen, S.-J.

Subjects
Acute leukemia, Promyelocytic -- Genetic aspects, Chromosome abnormalities -- Research, Translocation (Genetics) -- Research, Gene fusion -- Research, Science and technology
Abstract

Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation involving RAR[Alpha] and one of four fusion partners: PML, PLZF, NPM, and NuMA genes. To study the leukemogenic potential of the fusion genes in vivo, we generated transgenic mice with PLZF-RAR[Alpha] and NPM-RAR[Alpha]. PLZF-RAR[Alpha] transgenic animals developed chronic myeloid leukemia-like phenotypes at an early stage of life (within 3 months in five of six mice), whereas three NPM-RAR[Alpha] transgenic mice showed a spectrum of phenotypes from typical APL to chronic myeloid leukemia relatively late in life (from 12 to 15 months). In contrast to bone marrow cells from PLZFRAR[Alpha] transgenic mice, those from NPM-RAR[Alpha] transgenic mice could be induced to differentiate by all-trans-retinoic acid (ATRA). We also studied RARE binding properties and interactions between nuclear corepressor SMRT and various fusion proteins in response to ATRA. Dissociation of SMRT from different receptors was observed at ATRA concentrations of 0.01 [[micro]molar], 0.1 [[micro]molar], and 1.0 [[micro]molar] for RAR[Alpha]-RXR[Alpha], NPM-RAR[Alpha], and PML-RAR[Alpha], respectively, but not observed for PLZF-RAR[Alpha] even in the presence of 10 [[micro]molar] ATRA. We also determined the expression of the tissue factor gene in transgenic mice, which was detected only in bone marrow cells of mice expressing the fusion genes. These data clearly establish the leukemogenic role of PLZF-RAR[Alpha] and NPM-RAR[Alpha] and the importance of fusion receptor/corepressor interactions in the pathogenesis as well as in determining different clinical phenotypes of APL.

Published
1999

44. Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

Author

Koken, M.H.M., Reid, A., Quignon, F., Cihelbi-Alix, M.K., Davies, J.M., Kabarowski, J.H.S., Zhu, J., Dong, S., Chen, S-J., Chen, Z., Tan, C.C., Licht, J., Waxman, S., The, H. De, and Zelent, A.

Subjects
Acute leukemia, Promyelocytic -- Genetic aspects, Interferon -- Analysis, Translocation (Genetics) -- Research, Science and technology
Abstract

In acute promyelocytic leukemia (APL), the typical t(15;17) and the rare t(11;17) translocations express, respectively, the PML/RAR[Alpha] and PLZF/RAR[Alpha] fusion proteins (where RAR[Alpha] is retinoic acid receptor [Alpha]). Herein, we demonstrate that the PLZF and PML proteins interact with each other and colocalize onto nuclear bodies (NBs). Furthermore, induction of PML expression by interferons leads to a recruitment of PLZF onto NBs without increase in the levels of the PLZF protein. PML/RAR[Alpha] and PLZF/RAR[Alpha] localize to the same microspeckled nuclear domains that appear to be common targets for the two fusion proteins in APL. Although PLZF/RAR[Alpha] does not affect the localization of PML, PML/ RAR[Alpha] delocalizes the endogenous PLZF protein in t(15;17)-positive NB4 cells, pointing to a hierarchy in the nuclear targeting of these proteins. Thus, our results unify the molecular pathogenesis of APL with at least two different RAR[Alpha] gene translocations and stress the importance of alterations of PLZF and RAR[Alpha] nuclear localizations in this disease.

Published
1997

50. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Author

Alexander, Stephen PH, Kelly, Eamonn, Marrion, Neil V, Peters, John A, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Buneman, O Peter, Cidlowski, John A, Christopoulos, Arthur, Davenport, Anthony P, Fabbro, Doriano, Spedding, Michael, Striessnig, Jörg, Davies, Jamie A, Abbracchio, M. -P., Aldrich, R., Al-Hosaini, K., Arumugam, T. V., Attali, B., Bäck, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M., Birdsall, N. J., Blaho, V., Boison, D., Bräuner-osborne, H., Bröer, S., Bryant, C., Burnstock, G., Calo, G., Catterall, W. A., Ceruti, S., Chan, S. L., Chandy, K. G., Chazot, P., Chiang, N., Chun, J. J., Chung, J. -J., Clapham, D. E., Clapp, L., Connor, M. A., Cox, H. M., Davies, P., Dawson, P. A., Decaen, P., Dent, G., Doherty, P., Douglas, S. D., Dubocovich, M. L., Fong, T. M., Fowler, C. J., Frantz, A., Fuller, P., Fumagalli, M., Futerman, A. H., Gainetdinov, R. R., Gershengorn, M. A., Goldin, A., Goldstein, S. A. N., Goudet, C., Gregory, K., Grissmer, S., Gundlach, A. L., Hagenbuch, B., Hamann, J., Hammond, J. R., Hancox, J. C., Hanson, J., Hanukoglu, I., Hay, D. L., Hobbs, A. J., Hollenberg, A. N., Holliday, N. D., Hoyer, D., Ijzerman, A. P., Inui, K. I., Irving, A. J., Ishii, S., Jacobson, K. A., Jan, L. Y., Jarvis, M. F., Jensen, R., Jockers, R., Kaczmarek, L. K., Kanai, Y., Karnik, S., Kellenberger, S., Kemp, S., Kennedy, C., Kerr, I. D., Kihara, Y., Kukkonen, J., Larhammar, D., Leach, K., Lecca, D., Leeman, S., Leprince, J., Lolait, S. J., Macewan, D., Maguire, J. J., Marshall, F., Mazella, J., Mcardle, C. A., Michel, M. C., Miller, L. J., Mitolo, V., Mizuno, H., Monk, P. N., Mouillac, B., Murphy, P. M., Nahon, J. -L., Nerbonne, J., Nichols, C. G., Norel, X., Offermanns, S., Palmer, L. G., Panaro, M. A., Papapetropoulos, A., Perez-reyes, E., Pertwee, R. G., Pintor, S., Pisegna, J. R., Plant, L. D., Poyner, D. R., Prossnitz, E. R., Pyne, S., Ramachandran, R., Ren, D., Rondard, P., Ruzza, C., Sackin, H., Sanger, G., Sanguinetti, M. C., Schild, L., Schiöth, H., Schulte, G., Schulz, S., Segaloff, D. L., Serhan, C. N., Singh, K. D., Slesinger, P. A., Snutch, T. P., Sobey, C. G., Stewart, G., Stoddart, L. A., Summers, R. J., Szabo, C., Thwaites, D., Toll, L., Trimmer, J. S., Tucker, S., Vaudry, H., Verri, T., Vilargada, J. -P., Waldman, S. A., Ward, D. T., Waxman, S. G., Wei, A. D., Willars, G. B., Wong, S. S., Woodruff, T. M., Wulff, H., Ye, R. D., Yung, Y., Zajac, J. -M., Alexander, Stephen PH, Kelly, Eamonn, Marrion, Neil V, Peters, John A, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Buneman, O Peter, Cidlowski, John A, Christopoulos, Arthur, Davenport, Anthony P, Fabbro, Doriano, Spedding, Michael, Striessnig, Jörg, Davies, Jamie A, Abbracchio, M. -P., Aldrich, R., Al-Hosaini, K., Arumugam, T. V., Attali, B., Bäck, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M., Birdsall, N. J., Blaho, V., Boison, D., Bräuner-osborne, H., Bröer, S., Bryant, C., Burnstock, G., Calo, G., Catterall, W. A., Ceruti, S., Chan, S. L., Chandy, K. G., Chazot, P., Chiang, N., Chun, J. J., Chung, J. -J., Clapham, D. E., Clapp, L., Connor, M. A., Cox, H. M., Davies, P., Dawson, P. A., Decaen, P., Dent, G., Doherty, P., Douglas, S. D., Dubocovich, M. L., Fong, T. M., Fowler, C. J., Frantz, A., Fuller, P., Fumagalli, M., Futerman, A. H., Gainetdinov, R. R., Gershengorn, M. A., Goldin, A., Goldstein, S. A. N., Goudet, C., Gregory, K., Grissmer, S., Gundlach, A. L., Hagenbuch, B., Hamann, J., Hammond, J. R., Hancox, J. C., Hanson, J., Hanukoglu, I., Hay, D. L., Hobbs, A. J., Hollenberg, A. N., Holliday, N. D., Hoyer, D., Ijzerman, A. P., Inui, K. I., Irving, A. J., Ishii, S., Jacobson, K. A., Jan, L. Y., Jarvis, M. F., Jensen, R., Jockers, R., Kaczmarek, L. K., Kanai, Y., Karnik, S., Kellenberger, S., Kemp, S., Kennedy, C., Kerr, I. D., Kihara, Y., Kukkonen, J., Larhammar, D., Leach, K., Lecca, D., Leeman, S., Leprince, J., Lolait, S. J., Macewan, D., Maguire, J. J., Marshall, F., Mazella, J., Mcardle, C. A., Michel, M. C., Miller, L. J., Mitolo, V., Mizuno, H., Monk, P. N., Mouillac, B., Murphy, P. M., Nahon, J. -L., Nerbonne, J., Nichols, C. G., Norel, X., Offermanns, S., Palmer, L. G., Panaro, M. A., Papapetropoulos, A., Perez-reyes, E., Pertwee, R. G., Pintor, S., Pisegna, J. R., Plant, L. D., Poyner, D. R., Prossnitz, E. R., Pyne, S., Ramachandran, R., Ren, D., Rondard, P., Ruzza, C., Sackin, H., Sanger, G., Sanguinetti, M. C., Schild, L., Schiöth, H., Schulte, G., Schulz, S., Segaloff, D. L., Serhan, C. N., Singh, K. D., Slesinger, P. A., Snutch, T. P., Sobey, C. G., Stewart, G., Stoddart, L. A., Summers, R. J., Szabo, C., Thwaites, D., Toll, L., Trimmer, J. S., Tucker, S., Vaudry, H., Verri, T., Vilargada, J. -P., Waldman, S. A., Ward, D. T., Waxman, S. G., Wei, A. D., Willars, G. B., Wong, S. S., Woodruff, T. M., Wulff, H., Ye, R. D., Yung, Y., and Zajac, J. -M.

Subjects
Pharmacology
Abstract

The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified ‘Other protein targets’ which fall outside of the subsequent categorisation, there are eight areas of focus: G protein‐coupled receptors, ligand‐gated ion channels, voltage‐gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Published
2017

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