103 results on '"Wauters, C."'
Search Results
2. Performance characteristics of specimen radiography for margin assessment for ductal carcinoma in situ: a systematic review
- Author
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Versteegden, D. P. A., Keizer, L. G. G., Schlooz-Vries, M. S., Duijm, L. E. M., Wauters, C. A. P., and Strobbe, L. J. A.
- Published
- 2017
- Full Text
- View/download PDF
3. Sentinel lymph node biopsy can be omitted in DCIS patients treated with breast conserving therapy
- Author
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van Roozendaal, L. M., Goorts, B., Klinkert, M., Keymeulen, K. B. M. I., De Vries, B., Strobbe, L. J. A., Wauters, C. A. P., van Riet, Y. E., Degreef, E., Rutgers, E. J. T., Wesseling, J., and Smidt, M. L.
- Published
- 2016
- Full Text
- View/download PDF
4. Conclusiveness of fine needle aspiration in 2419 histologically confirmed benign and malignant breast lesions
- Author
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Kooistra, B., Wauters, C., Wobbes, T., and Strobbe, L.
- Published
- 2011
- Full Text
- View/download PDF
5. Ultrasound-guided fine-needle aspiration of suspicious nodes in breast cancer patients; selecting patients with extensive nodal involvement
- Author
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van Wely, B. J., de Wilt, J. H. W., Schout, P. J. C., Kooistra, B., Wauters, C. A. P., Venderinck, D., and Strobbe, L. J. A.
- Published
- 2013
- Full Text
- View/download PDF
6. Contribution of CSF cytology in the diagnostic work-up of breast cancer patients with neurological symptoms: a retrospective analysis over two decades
- Author
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Wauters, C. A. P., Poelen, J., Mulder, I., Venderink, D., Strobbe, L. J. A., and Wesseling, P.
- Published
- 2012
- Full Text
- View/download PDF
7. PO-0973: Axillary lymph node dissection after neoadjuvant chemotherapy for node-positive breast cancer.
- Author
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Van Zeeland, M., primary, Westhoff, P., additional, Wauters, C., additional, Bult, P., additional, Werner, A., additional, Laurens, N., additional, Strobbe, L., additional, and Meijer, H., additional
- Published
- 2020
- Full Text
- View/download PDF
8. Modified core wash cytology procedure for the immediate diagnosis of core needle biopsies of breast lesions
- Author
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Wauters, C. A. P., Sanders-Eras, C. T., Kooistra, B. W., and Strobbe, L. J. A.
- Published
- 2009
- Full Text
- View/download PDF
9. The role of laboratory processing in determining diagnostic conclusiveness of breast fine needle aspirations: conventional smearing versus a monolayer preparation
- Author
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Wauters, C A P, Kooistra, B, and Strobbe, L J A
- Published
- 2009
- Full Text
- View/download PDF
10. False-negative sentinel lymph node biopsy
- Author
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van Wely, B. J., Smidt, M. L., de Kievit, I. M., Wauters, C. A. P., and Strobbe, L. J. A.
- Published
- 2008
11. Intraoperative scrape cytology of the sentinel lymph node in patients with breast cancer
- Author
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Smidt, M. L., Besseling, R., Wauters, C. A. P., and Strobbe, L. J. A.
- Published
- 2002
12. Intraoperative lymphatic mapping and the sentinel node concept in colorectal carcinoma
- Author
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Joosten, J. J. A., Strobbe, L. J. A., Wauters, C. A. P., Pruszczynski, M., Wobbes, Th., and Ruers, T. J. M.
- Published
- 1999
13. Effect of the relative shift between the electron density and temperature pedestal position on the pedestal stability in JET-ILW and comparison with JET-C
- Author
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Stefanikova, E., Frassinetti, L., Saarelma, S., Loarte, A., Nunes, I., Garzotti, L., Lomas, P., Rimini, F., Drewelow, P., Kruezi, U., Lomanowski, B., De La Luna, E., Meneses, L., Peterka, M., Viola, B., Giroud, C., Litaudon, Maggi C., Abduallev, X., Abhangi, S., Abreu, M., Afzal, P., Aggarwal, M., Ahlgren, K. M., Ahn, T., J. H., Aho, Mantila, Aiba, L., Airila, N., Albanese, M., Aldred, R., Alegre, V., Alessi, D., Aleynikov, E., Alfier, P., Alberto, Alkseev, Allinson, A., Alper, M., Alves, B., Ambrosino, E., Ambrosino, G., Amicucci, R., Amosov, L., Andersson, Sundã©n, Angelone, E., Anghel, M., Angioni, M., Appel, C., Appelbee, L., Arena, C., Ariola, P., Arnichand, M., Arshad, H., Ash, S., Ashikawa, A., Aslanyan, N., Asunta, V., Auriemma, O., Fulvio, Austin, Avotina, Y., Axton, L., Ayres, M. D., Bacharis, C., Baciero, M., Baiã¡o, A., Bailey, D., Baker, S., Balboa, A., Balden, I., Balshaw, M., Bament, N., Banks, R., Baranov, J. W., Barnard, Y. F., Barnes, M. A., Barnes, D., Barnsley, M., Baron, Wiechec, Barrera, Orte, Baruzzo, L., Matteo, Basiuk, Bassan, V., Bastow, M., Batista, R., Batistoni, A., Baughan, P., Bauvir, R., Baylor, B., Bazylev, L., Beal, B., Beaumont, J., Beckers, P. S., Beckett, M., Becoulet, B., Bekris, A., Beldishevski, N., Bell, M., Belli, K., Bellinger, F., Belonohy, M., Ben, Ayed, Benterman, N., Bergsã¥ker, N. A., Bernardo, H., Bernert, J., Berry, M., Bertalot, M., Besliu, L., Beurskens, C., Bieg, M., Bielecki, B., Biewer, J., Bigi, T., Bã¬lkovã¡, M., Binda, P., Bisoffi, F., Bizarro, A., Bjã¶rkas, J. P. S., Blackburn, C., Blackman, J., Blackman, K., Blanchard, T. R., Blatchford, P., Bobkov, P., Boboc, V., Bodnã¡r, A., Bogar, G., Bolshakova, O., Bolzonella, I., Tommaso, Bonanomi, Bonelli, N., Boom, F., Booth, J., Borba, J., Borodin, D., Borodkina, D., Botrugno, I., Bottereau, A., Boulting, C., Bourdelle, P., Bowden, C., Bower, M., Bowman, C., Boyce, C., Boyd, T., Boyer, C., Bradshaw, H. J., Braic, J. M. A., Bravanec, V., Breizman, R., Bremond, B., Brennan, S., Breton, P. D., Brett, S., Brezinsek, A., Bright, S., Brix, M. D. J., Broeckx, M., Brombin, W., Matteo, Broså‚awski, Brown, A., Brown, D. P. D., Bruno, M., Bucalossi, E., Buch, J., Buchanan, J., Buckley, J., Budny, M. A., Bufferand, R., Bulman, H., Bulmer, M., Bunting, N., Buratti, P., Burckhart, P., Buscarino, A., Busse, A., Butler, A., Bykov, N. K., Byrne, I., Cahyna, J., Calabrã², P., Calvo, G., Camenen, I., Camp, Y., Campling, P., Cane, D. C., Cannas, J., Capel, B., Card, A. J., Cardinali, P. J., Carman, A., Carr, P., Carralero, M., Carraro, D., Carvalho, L., Carvalho, B. B., Carvalho, I., Casson, P., Castaldo, F. J., Catarino, C., Caumont, N., Causa, J., Cavazzana, F., Cave, Ayland, Cavinato, K., Cecconello, M., Ceccuzzi, M., Cecil, S., Cenedese, E., Angelo, Cesario, Challis, R., Chandler, C. D., Chandra, M., Chang, D., Chankin, C. S., Chapman, A., Chapman, I. T., Chernyshova, S. C., Chitarin, M., Giuseppe, Ciraolo, Ciric, G., Citrin, D., Clairet, J., Clark, F., Clark, E., Clarkson, M., Clatworthy, R., Clements, D., Cleverly, C., Coad, M., Coates, J. P., Cobalt, P. A., Coccorese, A., Cocilovo, V., Coda, V., Coelho, S., Coenen, R., Coffey, J. W., Colas, I., Collins, L., Conka, S., Conroy, D., Conway, S., Coombs, N., Cooper, D., Corradino, S. R., Corre, C., Corrigan, Y., Cortes, G., Coster, S., Couchman, D., Cox, A. S., Craciunescu, M. P., Cramp, T., Craven, S., Crisanti, R., Croci, F., Croft, G., Crombã©, D., Crowe, K., Cruz, R., Cseh, N., Cufar, G., Cullen, A., Curuia, A., Czarnecka, M., Dabirikhah, A., Dalgliesh, H., Dalley, P., Dankowski, S., Darrow, J., Davies, D., Davis, O., Day, W., Day, C., I. E., Bock, De, Castro, De, De La Cal, De La Luna, Masi, De, Pablos, De, J. L., Temmerman, De, Tommasi, De, Vries, De, Deakin, P., Deane, K., Degli, Agostini, Dejarnac, F., Delabie, R., Den, Harder, Dendy, N., Denis, R. O., Denner, J., Devaux, P., Devynck, S., Maio, Di, Siena, Di, Troia, Di, Dinca, C., D'Inca, P., Ding, R., Dittmar, B., Doerk, T., Doerner, H., Donnã©, R. P., Dorling, T., S. E., Dormido, Canto, Doswon, S., Douai, S., Doyle, D., Drenik, P. T., Drewelow, A., Drews, P., Duckworth, P., Dumont, P. h., Dumortier, R., Dunai, P., Dunne, D., Äžuran, M., Durodiã©, I., Dutta, F., Duval, P., Dux, B. P., Dylst, R., Dzysiuk, K., Edappala, N., Edmond, P. V., Edwards, J., Edwards, A. M., Eich, J., Ekedahl, T. h., Jorf, El, Elsmore, R., Enachescu, C. G., Ericsson, M., Eriksson, G., Eriksson, F., Eriksson, J., Esposito, L. G., Esquembri, B., Esser, S., Esteve, H. G., Evans, D., Evans, B., Evison, G. E., Ewart, G., Fagan, G. D., Faitsch, D., Falie, M., Fanni, D., Fasoli, A., Faustin, A., Fawlk, J. M., Fazendeiro, N., Fedorczak, L., Felton, N., Fenton, R. C., Fernades, K., Fernandes, A., Ferreira, H., Fessey, J., Fã©vrier, J. A., Ficker, O., Field, O., Fietz, A., Figueiredo, S., Figueiredo, A., Fil, J., Finburg, A., Firdaouss, P., Fischer, M., Fittill, U., Fitzgerald, L., Flammini, M., Flanagan, D., Fleming, J., Flinders, C., Fonnesu, K., Fontdecaba, N., Formisano, J. M., Forsythe, A., Fortuna, L., Fortuna, Zalesna, Fortune, E., Foster, M., Franke, S., Franklin, T., Frasca, T., Frassinetti, M., Freisinger, L., Fresa, M., Frigione, R., Fuchs, D., Fuller, V., Futatani, D., Fyvie, S., Gã¡l, J., Galassi, K., Gaå‚azka, D., Galdon, Quiroga, Gallagher, J., Gallart, J., Galvã¡o, D., Gao, R., Gao, X., Garcia, Y., Garcia, Carrasco, Garcã¬a, Muã±oz, Gardarein, M., Garzotti, J. L., Gaudio, L., Gauthier, P., Gear, E., Gee, D. F., Geiger, S. J., Gelfusa, B., Gerasimov, M., Gervasini, S., Gethins, G., Ghani, M., Ghate, Z., Gherendi, M., Giacalone, M., Giacomelli, J. C., Gibson, L., Giegerich, C. S., Gil, T., Gil, C., Gilligan, L., Gin, S., Giovannozzi, D., Girardo, E., Giroud, J. B., Giruzzi, C., Gerardo, Glã¶ggler, Godwin, S., Goff, J., Gohil, J., Goloborod'Ko, P., Gomes, V., Goncalves, R., Goniche, B., Goodliffe, M., Goodyear, M., Gorini, A., Gosk, G., Goulding, M., Goussarov, R., Gowland, A., Graham, R., Graham, B., Graves, M. E., Grazier, J. P., Grazier, N., Green, P., Greuner, N. R., Grierson, H., Griph, B., Grisolia, F. S., Grist, C., Groth, D., Grove, M., Grundy, R., Grzonka, C. N., Guard, J., Guã©rard, D., Guillemaut, C., Guirlet, C., Gurl, R., Utoh, C., Hackett, H. H., Hacquin, L. J., Hagar, S., Hager, A., Hakola, R., Halitovs, A., Hall, M., S. J., Hallworth, Cook, S. P., Hamlyn, Harris, Hammond, C., Harrington, K., Harrison, C., Harting, J., Hasenbeck, D., Hatano, F., Hatch, Y., Haupt, D. R., Hawes, T. D. V., Hawkes, J., Hawkins, N. C., Hawkins, J., Haydon, P., Hayter, P. W., Hazel, N., Heesterman, S., Heinola, P. J. L., Hellesen, K., Hellsten, C., Helou, T., Hemming, W., Hender, O. N., Henderson, T. C., Henderson, M., Henriques, S. S., Hepple, R., Hermon, D., Hertout, G., Hidalgo, P., Highcock, C., Hill, E. G., Hillairet, M., Hillesheim, J., Hillis, J., Hizanidis, D., Hjalmarsson, K., Hobirk, A., Hodille, J., Hogben, E., Hogeweij, C. H. A., Hollingsworth, G. M. D., Hollis, A., Homfray, S., Horã¡äek, D. A., Hornung, J., Horton, G., Horton, A. R., Horvath, L. D., Hotchin, L., Hough, S. P., Howarth, M. R., Hubbard, P. J., Huber, A., Huddleston, V., Hughes, T. M., Huijsmans, M., Hunter, G. T. A., Huynh, C. L., Hynes, P., Iglesias, A. M., Imazawa, D., Imbeaux, N., Imrã¬å¡ek, F., Incelli, M., Innocente, M., Irishkin, P., Ivanova, Stanik, Jachmich, I., Jacobsen, S., Jacquet, A. S., Jansons, P., Jardin, J., Jã¤rvinen, A., Jaulmes, A., Jednorã³g, F., Jenkins, S., Jeong, I., Jepu, C., Joffrin, I., Johnson, E., Johnson, R., Johnston, T., Jane, Joita, Jones, L., Jones, G., Hoshino, T. T. C., Kallenbach, K. K., Kamiya, A., Kaniewski, K., Kantor, J., Kappatou, A., Karhunen, A., Karkinsky, J., Karnowska, D., Kaufman, I., Kaveney, M., Kazakov, G., Kazantzidis, Y., Keeling, V., Keenan, D. L., Keep, T., Kempenaars, J., Kennedy, M., Kenny, C., Kent, D., Kent, J., Khilkevich, O. N., Kim, E., Kim, H. T., Kinch, H. S., King, A., King, C., King, D., Kinna, R. F., Kiptily, D. J., Kirk, V., Kirov, A., Kirschner, K., Kizane, A., Klepper, G., Klix, C., Knight, A., Knipe, P., Knott, S. J., Kobuchi, S., Kã¶chl, T., Kocsis, F., Kodeli, G., Kogan, I., Kogut, L., Koivuranta, D., Kominis, S., Kã¶ppen, Y., Kos, M., Koskela, B., Koslowski, T., Koubiti, H. R., Kovari, M., Kowalska, Strzè©ciwilk, Krasilnikov, E., Krasilnikov, A., Krawczyk, V., Kresina, N., Krieger, M., Krivska, K., Kruezi, A., Ksiaå¼ek, U., Kukushkin, I., Kundu, A., Kurki, Suonio, Kwak, T., Kwiatkowski, S., Kwon, R., Laguardia, O. J., Lahtinen, L., Laing, A., Lam, A., Lambertz, N., Lane, H. T., Lang, C., Lanthaler, P. T., Lapins, S., Lasa, J., Last, A., Åaszyå„ska, J. R., Lawless, E., Lawson, R., Lawson, A., Lazaros, K. D., Lazzaro, A., Leddy, E., Lee, J., Lefebvre, S., Leggate, X., Lehmann, H. J., Lehnen, J., Leichtle, M., Leichuer, D., Leipold, P., Lengar, F., Lennholm, I., Lerche, M., Lescinskis, E., Lesnoj, A., Letellier, S., Leyland, E., Leysen, M., Li, W., Liang, L., Likonen, Y., Linke, J., Linsmeier, J., Lipschultz, C. h., Liu, B., Liu, G., Schiavo, Lo, Loarer, V. P., Loarte, T., Lobel, A., Lomanowski, R. C., Lomas, B., Lã¶nnroth, P. J., Lã³pez, J., J. M., Lã³pez, Razola, Lorenzini, J., Losada, R., Lovell, U., Loving, J. J., Lowry, A. B., Luce, C., Lucock, T., Lukin, R. M. A., Luna, A., Lungaroni, C., Lungu, M., Lungu, C. P., Lunniss, M., Lupelli, A., Lyssoivan, I., Macdonald, A., Macheta, N., Maczewa, P., Magesh, K., Maget, B., Maggi, P., Maier, C., Mailloux, H., Makkonen, J., Makwana, T., Malaquias, R., Malizia, A., Manas, A., Manning, P., Manso, A., Mantica, M. E., Mantsinen, P., Manzanares, M., Maquet, A., Marandet, P. h., Marcenko, Y., Marchetto, N., Marchuk, C., Marinelli, O., Marinucci, M., Markoviä, M., Marocco, T., Marot, D., Marren, L., Marshal, C. A., Martin, R., Martin, A., Martìn De Aguilera, Martã¬nez, A., F. J., Martã¬n, Solã¬s, Martynova, J. R., Maruyama, Y., Masiello, S., Maslov, A., Matejcik, M., Mattei, S., Matthews, M., Maviglia, G. F., Mayer, F., Mayoral, M., M. L., May, Smith, Mazon, T., Mazzotta, D., Mcadams, C., Mccarthy, R., Mcclements, P. J., Mccormack, K. G., Mccullen, O., Mcdonald, P. A., Mcintosh, D., Mckean, S., Mckehon, R., Meadows, J., Meakins, R. C., Medina, A., Medland, F., Medley, M., Meigh, S., Meigs, S., Meisl, A. G., Meitner, G., Meneses, S., Menmuir, L., Mergia, S., Merrigan, K., Mertens, I. R., Meshchaninov, P. h., Messiaen, S., Meyer, A., Mianowski, H., Michling, S., Middleton, Gear, Miettunen, D., Militello, J., Militello, Asp, Miloshevsky, E., Mink, G., Minucci, F., Miyoshi, S., Mlynã¡å™, Y., Molina, J., Monakhov, D., Moneti, I., Mooney, M., Moradi, R., Mordijck, S., Moreira, S., Moreno, L., Moro, R., Morris, F., Morris, A. W., Moser, J., Mosher, L., Moulton, S., Murari, D., Muraro, A., Murphy, A., Asakura, S., N. N., Na, Nabais, Y. S., Naish, F., Nakano, R., Nardon, T., Naulin, E., Nave, V., Nedzelski, M. F. F., Nemtsev, I., Nespoli, G., Neto, F., Neu, A., Neverov, R., Newman, V. S., Nicholls, M., Nicolas, K. J., Nielsen, T., Nielsen, A. H., Nilsson, P., Nishijima, E., Noble, D., Nocente, C., Nodwell, M., Nordlund, D., Nordman, K., Nouailletas, H., Nunes, R., Oberkofler, I., Odupitan, M., Ogawa, T., O'Gorman, M. T., Okabayashi, T., Olney, M., Omolayo, R., O'Mullane, O., Ongena, M., Orsitto, J., Orszagh, F., Oswuigwe, J., Otin, B. I., Owen, R., Paccagnella, A., Pace, R., Pacella, N., Packer, D., Page, L. W., Pajuste, A., Palazzo, E., Pamela, S., Panja, S., Papp, S., Paprok, P., Parail, R., Park, V., Parra, Diaz, Parsons, F., Pasqualotto, M., Patel, R., Pathak, A., Paton, S., Patten, D., Pau, H., Pawelec, A., Paz, Soldan, Peackoc, C., Pearson, A., Pehkonen, I. J., Peluso, S. P., Penot, E., Pereira, C., Pereira, A., Pereira, Puglia, P. P., Perez Von Thun, Peruzzo, C., Peschanyi, S., Peterka, S., Petersson, M., Petravich, P., Petre, G., Petrella, A., Petrå¾ilka, N., Peysson, V., Pfefferlã©, Y., Philipps, D., Pillon, V., Pintsuk, M., Piovesan, G., Pires Dos Reis, Piron, Lidia, Pironti, A., Pisano, F., Pitts, R., Pizzo, F., Plyusnin, V., Pomaro, N., Pompilian, O. G., Pool, P. J., Popovichev, S., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Powell, T., Pozzi, J., Prajapati, V., Prakash, R., Prestopino, G., Price, D., Price, M., Price, R., Prior, P., Proudfoot, R., Pucella, G., Puglia, P., Puiatti, M. E., Pulley, D., Purahoo, K., Pã¼tterich, T. h., Rachlew, E., Rack, M., Ragona, R., Rainford, M. S. J., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, J. J., Rathod, K., Rattã¡, G., Ratynskaia, S., Ravera, G., Rayner, C., Rebai, M., Reece, D., Reed, A., Rã©fy, D., Regan, B., Regaã±a, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes, Cortes, Reynolds, S. D. A., Riccardo, S., Richardson, V., Riddle, N., Rigamonti, K., Rimini, D., Risner, F. G., Riva, J., Roach, M., Robins, C., Robinson, R. J., Robinson, S. A., Robson, T., Roccella, D. W., Rodionov, R., Rodrigues, R., Rodriguez, P., Rohde, J., Romanelli, V., Romanelli, F., Romanelli, M., Romazanov, S., Rowe, J., Rubel, S., Rubinacci, M., Rubino, G., Ruchko, G., Ruiz, L., Ruset, M., Rzadkiewicz, C., Saarelma, J., Sabot, S., Safi, R., Sagar, E., Saibene, P., Saint, Laurent, Salewski, F., Salmi, M., Salmon, A., Salzedas, R., Samaddar, F., Samm, D., Sandiford, U., Santa, D., Santala, P., Santos, M. I. K., Santucci, B., Sartori, A., Sartori, F., Sauter, R., Scannell, O., Schlummer, R., Schmid, T., Schmidt, K., Schmuck, V., Schneider, S., Schã¶pf, M., Schwã¶rer, K., Scott, D., Sergienko, S. D., Sertoli, G., Shabbir, M., Sharapov, A., Shaw, S. E., Shaw, A., Sheikh, R., Shepherd, H., Shevelev, A., Shumack, A., Sias, A., Sibbald, G., Sieglin, M., Silburn, B., Silva, S., Silva, A., Simmons, C., Simpson, P. A., Simpson, Hutchinson, Sinha, J., Sipilã¤, A., Sips, S. K., Sirã©n, A. C. C., Sirinelli, P., Sjã¶strand, A., Skiba, H., Skilton, M., Slabkowska, R., Slade, K., Smith, B., Smith, N., Smith, P. G., Smith, R., Smithies, T. J., Snoj, M., Soare, L., Solano, S., Somers, E. R., Sommariva, A., Sonato, C., Piergiorgio, Sopplesa, Sousa, A., Sozzi, J., Spagnolo, C., Silvia, Spelzini, Spineanu, T., Stables, F., Stamatelatos, G., Stamp, I., Staniec, M. F., Stankå«nas, P., Stan, Sion, Stead, C., Stefanikova, M. J., Stepanov, E., Stephen, I., Stephen, A. V., Stevens, M., Stevens, A., Strachan, B. D., Strand, J., Strauss, P., Strã¶m, H. R., Stubbs, P., Studholme, G., Subba, W., Summers, F., Svensson, H. P., Åšwiderski, J., Szabolics, Å. ., Szawlowski, T., Szepesi, M., Suzuki, G., Tã¡l, T. T., Tala, B., Talbot, T., Talebzadeh, A. R., Taliercio, S., Cesare, Tamain, Tame, P., Tang, C., Tardocchi, W., Taroni, M., Taylor, L., Taylor, D., Tegnered, K. A., Telesca, D., Teplova, G., Terranova, N., David, Testa, Tholerus, D., Thomas, E., Thomas, J., Thomas, J. D., Thompson, P., Thompson, A., Thompson, C. A., Thorne, V. K., Thornton, L., Thrysã¸e, A., Tigwell, A. S., Tipton, P. A., Tiseanu, N., Tojo, I., Tokitani, H., Tolias, M., Tomeå¡, P., Tonner, M., Towndrow, P., Trimble, M., Tripsky, P., Tsalas, M., Tsavalas, M., Tskhakaya, Jun, Turner, D., Turner, I., Turnyanskiy, M. M., Tvalashvili, M., Tyrrell, G., Uccello, S. G. J., Abidin, Ul, Uljanovs, Z., Ulyatt, J., Urano, D., Uytdenhouwen, H., Vadgama, I., Valcarcel, A. P., Valentinuzzi, D., Valisa, M., Vallejos, Olivares, Valovic, P., Van De Mortel, Van, Eester, Van, Renterghem, Van, Rooij, Varje, G. J., Varoutis, J., Vartanian, S., Vasava, S., Vasilopoulou, K., Vega, T., Verdoolaege, J., Verhoeven, G., Verona, R., Verona, Rinati, Veshchev, G., Vianello, E., Vicente, N., Viezzer, J., Villari, E., Villone, S., Vincenzi, F., Pietro, Vinyar, Viola, I., Vitins, B., Vizvary, A., Vlad, Z., Voitsekhovitch, M., Vondrã¡äek, I., Vora, P., Vu, N., Pires De Sa, Wakeling, W. W., Waldon, B., Walkden, C. W. F., Walker, N., Walker, M., Walsh, R., Wang, M., Wang, E., Warder, N., Warren, S., Waterhouse, R. J., Watkins, J., Watts, N. W., Wauters, C., Weckmann, T., Weiland, A., Weisen, J., Weiszflog, H., Wellstood, M., West, C., Wheatley, A. T., Whetham, M. R., Whitehead, S., Whitehead, A. M., Widdowson, B. D., Wiesen, A. M., Wilkinson, S., Williams, J., Wilson, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wischmeier, J., Withenshaw, M., Withycombe, G., Witts, A., Wood, D. M., Wood, D., Woodley, R., Wray, C., Wright, S., Wright, J., J. C., Wu, Wukitch, J., Wynn, S., Xu, A., Yadikin, T., Yanling, D., Yao, W., Yavorskij, L., Yoo, V., Young, M. G., Young, C., Young, D., Young, I. D., Zacks, R., Zagorski, J., Zaitsev, R., Zanino, F. S., Zarins, R., Zastrow, A., Zerbini, K. D., Zhang, M., Zhou, W., Zilli, Y., Zoita, E., Zoletnik, V., Zychor, S., I, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. RNM138: Física Nuclear Aplicada, JET Contributors, Viola, B., Department of Physics, and Materials Physics
- Subjects
Nuclear and High Energy Physics ,Electron density ,Materials science ,Physics::Instrumentation and Detectors ,Thomson scattering ,education ,114 Physical sciences ,01 natural sciences ,010305 fluids & plasmas ,Pedestal ,ASDEX Upgrade ,Physics::Plasma Physics ,Position (vector) ,0103 physical sciences ,Pedestal position ,pedestal stability ,010306 general physics ,Jet (fluid) ,EUROPED ,JET ,pedestal ,pedestal position ,Pedestal stability ,Plasma ,Condensed Matter Physics ,Electron temperature ,Atomic physics ,physics - Abstract
The electron temperature and density pedestals tend to vary in their relative radial positions, as observed in DIII-D (Beurskens et al 2011 Phys. Plasmas 18 056120) and ASDEX Upgrade (Dunne et al 2017 Plasma Phys. Control. Fusion 59 14017). This so-called relative shift has an impact on the pedestal magnetohydrodynamic (MHD) stability and hence on the pedestal height (Osborne et al 2015 Nucl. Fusion 55 063018). The present work studies the effect of the relative shift on pedestal stability of JET ITER-like wall (JET-ILW) baseline low triangularity (δ) unseeded plasmas, and similar JET-C discharges. As shown in this paper, the increase of the pedestal relative shift is correlated with the reduction of the normalized pressure gradient, therefore playing a strong role in pedestal stability. Furthermore, JET-ILW tends to have a larger relative shift compared to JET carbon wall (JET-C), suggesting a possible role of the plasma facing materials in affecting the density profile location. Experimental results are then compared with stability analysis performed in terms of the peeling-ballooning model and with pedestal predictive model EUROPED (Saarelma et al 2017 Plasma Phys. Control. Fusion). Stability analysis is consistent with the experimental findings, showing an improvement of the pedestal stability, when the relative shift is reduced. This has been ascribed mainly to the increase of the edge bootstrap current, and to minor effects related to the increase of the pedestal pressure gradient and narrowing of the pedestal pressure width. Pedestal predictive model EUROPED shows a qualitative agreement with experiment, especially for low values of the relative shift. EURATOM 633053 Swedish Energy Agency 40146-1
- Published
- 2018
14. Isotope effects on L-H threshold and confinement in tokamak plasmas
- Author
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Maggi, C. F., Weisen, H., Hillesheim, J. C., Chankin, A., Delabie, E., Horvath, L., Auriemma, F., Carvalho, I. S., Corrigan, G., Flanagan, J., Garzotti, L., Keeling, D., King, D., Lerche, E., Lorenzini, R., Maslov, M., Menmuir, S., Saarelma, S., Sips, A. C. C., Solano, E. R., Belonohy, E., Casson, F. J., Challis, C., Giroud, C., Parail, V., Silva, C., Valisa, M., Lambertz, N., Lane, H. T., Lang, C., Lanthaler, P. T., Lapins, S., Lasa, J., Last, A., Åaszyå„ska, J. R., Lawless, E., Lawson, R., Lawson, A., Lazaros, K. D., Lazzaro, A., Leddy, E., Lee, J., Lefebvre, S., Leggate, X., Lehmann, H. J., Lehnen, J., Leichtle, M., Leichuer, D., Leipold, P., Lengar, F., Lennholm, I., Lerche, M., Lescinskis, E., Lesnoj, A., Letellier, S., Leyland, E., Leysen, M., Li, W., Liang, L., Likonen, Y., Linke, J., Linsmeier, J., Lipschultz, C. h., Liu, B., Liu, G., Schiavo, Lo, Loarer, V. P., Loarte, T., Lobel, A., Lomanowski, R. C., Lomas, B., Lã¶nnroth, P. J., Lã³pez, J., J. M., Lã³pez, Razola, Lorenzini, J., Losada, R., Lovell, U., Loving, J. J., Lowry, A. B., Luce, C., Lucock, T., Lukin, R. M. A., Luna, A., Lungaroni, C., Lungu, M., Lungu, C. P., Lunniss, M., Lupelli, A., Lyssoivan, I., Macdonald, A., Macheta, N., Maczewa, P., Magesh, K., Maget, B., Maggi, P., Maier, C., Mailloux, H., Makkonen, J., Makwana, T., Malaquias, R., Malizia, A., Manas, A., Manning, P., Manso, A., Mantica, M. E., Mantsinen, P., Manzanares, M., Maquet, A., Marandet, P. h., Marcenko, Y., Marchetto, N., Marchuk, C., Marinelli, O., Marinucci, M., Markoviä, M., Marocco, T., Marot, D., Marren, L., Marshal, C. A., Martin, R., Martin, A., Martìn De Aguilera, Martã¬nez, A., F. J., Martã¬n, Solã¬s, Martynova, J. R., Maruyama, Y., Masiello, S., Maslov, A., Matejcik, M., Mattei, S., Matthews, M., Maviglia, G. F., Mayer, F., Mayoral, M., M. L., May, Smith, Mazon, T., Mazzotta, D., Mcadams, C., Mccarthy, R., Mcclements, P. J., Mccormack, K. G., Mccullen, O., Mcdonald, P. A., Mcintosh, D., Mckean, S., Mckehon, R., Meadows, J., Meakins, R. C., Medina, A., Medland, F., Medley, M., Meigh, S., Meigs, S., Meisl, A. G., Meitner, G., Meneses, S., Menmuir, L., Mergia, S., Merrigan, K., Mertens, I. R., Meshchaninov, P. h., Messiaen, S., Meyer, A., Mianowski, H., Michling, S., Middleton, Gear, Miettunen, D., Militello, J., Militello, Asp, Miloshevsky, E., Mink, G., Minucci, F., Miyoshi, S., Mlynã¡å™, Y., Molina, J., Monakhov, D., Moneti, I., Mooney, M., Moradi, R., Mordijck, S., Moreira, S., Moreno, L., Moro, R., Morris, F., Morris, A. W., Moser, J., Mosher, L., Moulton, S., Murari, D., Muraro, A., Murphy, A., Asakura, S., N. N., Na, Nabais, Y. S., Naish, F., Nakano, R., Nardon, T., Naulin, E., Nave, V., Nedzelski, M. F. F., Nemtsev, I., Nespoli, G., Neto, F., Neu, A., Neverov, R., Newman, V. S., Nicholls, M., Nicolas, K. J., Nielsen, T., Nielsen, A. H., Nilsson, P., Nishijima, E., Noble, D., Nocente, C., Nodwell, M., Nordlund, D., Nordman, K., Nouailletas, H., Nunes, R., Oberkofler, I., Odupitan, M., Ogawa, T., O'Gorman, M. T., Okabayashi, T., Olney, M., Omolayo, R., O'Mullane, O., Ongena, M., Orsitto, J., Orszagh, F., Oswuigwe, J., Otin, B. I., Owen, R., Paccagnella, A., Pace, R., Pacella, N., Packer, D., Page, L. W., Pajuste, A., Palazzo, E., Pamela, S., Panja, S., Papp, S., Paprok, P., Parail, R., Park, V., Parra, Diaz, Parsons, F., Pasqualotto, M., Patel, R., Pathak, A., Paton, S., Patten, D., Pau, H., Pawelec, A., Paz, Soldan, Peackoc, C., Pearson, A., Pehkonen, I. J., Peluso, S. P., Penot, E., Pereira, C., Pereira, A., Pereira, Puglia, P. P., Perez Von Thun, Peruzzo, C., Peschanyi, S., Peterka, S., Petersson, M., Petravich, P., Petre, G., Petrella, A., Petråilka, N., Peysson, V., Pfefferlã©, Y., Philipps, D., Pillon, V., Pintsuk, M., Piovesan, G., Pires Dos Reis, Piron, Lidia, Pironti, A., Pisano, F., Pitts, R., Pizzo, F., Plyusnin, V., Pomaro, N., Pompilian, O. G., Pool, P. J., Popovichev, S., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Powell, T., Pozzi, J., Prajapati, V., Prakash, R., Prestopino, G., Price, D., Price, M., Price, R., Prior, P., Proudfoot, R., Pucella, G., Puglia, P., Puiatti, M. E., Pulley, D., Purahoo, K., Pã¼tterich, T. h., Rachlew, E., Rack, M., Ragona, R., Rainford, M. S. J., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, J. J., Rathod, K., Rattã¡, G., Ratynskaia, S., Ravera, G., Rayner, C., Rebai, M., Reece, D., Reed, A., Rã©fy, D., Regan, B., Regaã±a, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes, Cortes, Reynolds, S. D. A., Riccardo, S., Richardson, V., Riddle, N., Rigamonti, K., Rimini, D., Risner, F. G., Riva, J., Roach, M., Robins, C., Robinson, R. J., Robinson, S. A., Robson, T., Roccella, D. W., Rodionov, R., Rodrigues, R., Rodriguez, P., Rohde, J., Romanelli, V., Romanelli, F., Romanelli, M., Romazanov, S., Rowe, J., Rubel, S., Rubinacci, M., Rubino, G., Ruchko, G., Ruiz, L., Ruset, M., Rzadkiewicz, C., Saarelma, J., Sabot, S., Safi, R., Sagar, E., Saibene, P., Saint, Laurent, Salewski, F., Salmi, M., Salmon, A., Salzedas, R., Samaddar, F., Samm, D., Sandiford, U., Santa, D., Santala, P., Santos, M. I. K., Santucci, B., Sartori, A., Sartori, F., Sauter, R., Scannell, O., Schlummer, R., Schmid, T., Schmidt, K., Schmuck, V., Schneider, S., Schã¶pf, M., Schwã¶rer, K., Scott, D., Sergienko, S. D., Sertoli, G., Shabbir, M., Sharapov, A., Shaw, S. E., Shaw, A., Sheikh, R., Shepherd, H., Shevelev, A., Shumack, A., Sias, A., Sibbald, G., Sieglin, M., Silburn, B., Silva, S., Silva, A., Simmons, C., Simpson, P. A., Simpson, Hutchinson, Sinha, J., Sipilã¤, A., Sips, S. K., Sirã©n, A. C. C., Sirinelli, P., Sjã¶strand, A., Skiba, H., Skilton, M., Slabkowska, R., Slade, K., Smith, B., Smith, N., Smith, P. G., Smith, R., Smithies, T. J., Snoj, M., Soare, L., Solano, S., Somers, E. R., Sommariva, A., Sonato, C., Piergiorgio, Sopplesa, Sousa, A., Sozzi, J., Spagnolo, C., Silvia, Spelzini, Spineanu, T., Stables, F., Stamatelatos, G., Stamp, I., Staniec, M. F., Stankå«nas, P., Stan, Sion, Stead, C., Stefanikova, M. J., Stepanov, E., Stephen, I., Stephen, A. V., Stevens, M., Stevens, A., Strachan, B. D., Strand, J., Strauss, P., Strã¶m, H. R., Stubbs, P., Studholme, G., Subba, W., Summers, F., Svensson, H. P., Åšwiderski, J., Szabolics, Å. ., Szawlowski, T., Szepesi, M., Suzuki, G., Tã¡l, T. T., Tala, B., Talbot, T., Talebzadeh, A. R., Taliercio, S., Cesare, Tamain, Tame, P., Tang, C., Tardocchi, W., Taroni, M., Taylor, L., Taylor, D., Tegnered, K. A., Telesca, D., Teplova, G., Terranova, N., David, Testa, Tholerus, D., Thomas, E., Thomas, J., Thomas, J. D., Thompson, P., Thompson, A., Thompson, C. A., Thorne, V. K., Thornton, L., Thrysã¸e, A., Tigwell, A. S., Tipton, P. A., Tiseanu, N., Tojo, I., Tokitani, H., Tolias, M., Tomeå¡, P., Tonner, M., Towndrow, P., Trimble, M., Tripsky, P., Tsalas, M., Tsavalas, M., Tskhakaya, Jun, Turner, D., Turner, I., Turnyanskiy, M. M., Tvalashvili, M., Tyrrell, G., Uccello, S. G. J., Abidin, Ul, Uljanovs, Z., Ulyatt, J., Urano, D., Uytdenhouwen, H., Vadgama, I., Valcarcel, A. P., Valentinuzzi, D., Vallejos, Olivares, Valovic, P., Van De Mortel, Van, Eester, Van, Renterghem, Van, Rooij, Varje, G. J., Varoutis, J., Vartanian, S., Vasava, S., Vasilopoulou, K., Vega, T., Verdoolaege, J., Verhoeven, G., Verona, R., Verona, Rinati, Veshchev, G., Vianello, E., Vicente, N., Viezzer, J., Villari, E., Villone, S., Vincenzi, F., Pietro, Vinyar, Viola, I., Vitins, B., Vizvary, A., Vlad, Z., Voitsekhovitch, M., Vondrã¡äek, I., Vora, P., Vu, N., Pires De Sa, Wakeling, W. W., Waldon, B., Walkden, C. W. F., Walker, N., Walker, M., Walsh, R., Wang, M., Wang, E., Warder, N., Warren, S., Waterhouse, R. J., Watkins, J., Watts, N. W., Wauters, C., Weckmann, T., Weiland, A., Weisen, J., Weiszflog, H., Wellstood, M., West, C., Wheatley, A. T., Whetham, M. R., Whitehead, S., Whitehead, A. M., Widdowson, B. D., Wiesen, A. M., Wilkinson, S., Williams, J., Wilson, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wischmeier, J., Withenshaw, M., Withycombe, G., Witts, A., Wood, D. M., Wood, D., Woodley, R., Wray, C., Wright, S., Wright, J., J. C., Wu, Wukitch, J., Wynn, S., Xu, A., Yadikin, T., Yanling, D., Yao, W., Yavorskij, L., Yoo, V., Young, M. G., Young, C., Young, D., Young, I. D., Zacks, R., Zagorski, J., Zaitsev, R., Zanino, F. S., Zarins, R., Zastrow, A., Zerbini, K. D., Zhang, M., Zhou, W., Zilli, Y., Zoita, E., Zoletnik, V., Zychor, S., and JET Contributors
- Subjects
Tokamak ,Materials science ,Isotope ,Turbulence ,Magnetic confinement fusion ,L-H threshold ,Plasma ,Condensed Matter Physics ,01 natural sciences ,confinement ,isotope effects ,tokamaks ,010305 fluids & plasmas ,law.invention ,Ion ,Nuclear Energy and Engineering ,Physics::Plasma Physics ,law ,Physics::Space Physics ,0103 physical sciences ,Kinetic isotope effect ,Physics::Atomic Physics ,Atomic physics ,010306 general physics - Abstract
The dependence of plasma transport and confinement on the main hydrogenic ion isotope mass is of fundamental importance for understanding turbulent transport and, therefore, for accurate extrapolations of confinement from present tokamak experiments, which typically use a single hydrogen isotope, to burning plasmas such as ITER, which will operate in deuterium-tritium mixtures. Knowledge of the dependence of plasma properties and edge transport barrier formation on main ion species is critical in view of the initial, low-activation phase of ITER operations in hydrogen or helium and of its implications on the subsequent operation in deuterium-tritium. The favourable scaling of global energy confinement time with isotope mass, which has been observed in many tokamak experiments, remains largely unexplained theoretically. Moreover, the mass scaling observed in experiments varies depending on the plasma edge conditions. In preparation for upcoming deuterium-tritium experiments in the JET tokamak with the ITER-like Be/W Wall (JET-ILW), a thorough experimental investigation of isotope effects in hydrogen, deuterium and tritium plasmas is being carried out, in order to provide stringent tests of plasma energy, particle and momentum transport models. Recent hydrogen and deuterium isotope experiments in JET-ILW on L-H power threshold, L-mode and H-mode confinement are reviewed and discussed in the context of past and more recent isotope experiments in tokamak plasmas, highlighting common elements as well as contrasting observations that have been reported. The experimental findings are discussed in the context of fundamental aspects of plasma transport models.
- Published
- 2018
- Full Text
- View/download PDF
15. Erosion and deposition in the JET divertor during the second ITER-like wall campaign
- Author
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Mayer, M., Krat, S., Baron-Wiechec, A., Gasparyan, Y., Heinola, K., Koivuranta, S., Likonen, J., Ruset, C., De Saint-Aubin, G., Litaudon, Widdowson A., Abduallev, X., Abhangi, S., Abreu, M., Afzal, P., Aggarwal, M., Ahlgren, K. M., Ahn, T., J. H., Aho, Mantila, Aiba, L., Airila, N., Albanese, M., Aldred, R., Alegre, V., Alessi, D., Aleynikov, E., Alfier, P., Alberto, Alkseev, Allinson, A., Alper, M., Alves, B., Ambrosino, E., Ambrosino, G., Amicucci, R., Amosov, L., Andersson, Sundã©n, Angelone, E., Anghel, M., Angioni, M., Appel, C., Appelbee, L., Arena, C., Ariola, P., Arnichand, M., Arshad, H., Ash, S., Ashikawa, A., Aslanyan, N., Asunta, V., Auriemma, O., Fulvio, Austin, Avotina, Y., Axton, L., Ayres, M. D., Bacharis, C., Baciero, M., Baiã¡o, A., Bailey, D., Baker, S., Balboa, A., Balden, I., Balshaw, M., Bament, N., Banks, R., Baranov, J. W., Barnard, Y. F., Barnes, M. A., Barnes, D., Barnsley, M., Baron, Wiechec, Barrera, Orte, Baruzzo, L., Matteo, Basiuk, Bassan, V., Bastow, M., Batista, R., Batistoni, A., Baughan, P., Bauvir, R., Baylor, B., Bazylev, L., Beal, B., Beaumont, J., Beckers, P. S., Beckett, M., Becoulet, B., Bekris, A., Beldishevski, N., Bell, M., Belli, K., Bellinger, F., Belonohy, M., Ben, Ayed, Benterman, N., Bergsã¥ker, N. A., Bernardo, H., Bernert, J., Berry, M., Bertalot, M., Besliu, L., Beurskens, C., Bieg, M., Bielecki, B., Biewer, J., Bigi, T., Bã¬lkovã¡, M., Binda, P., Bisoffi, F., Bizarro, A., Bjã¶rkas, J. P. S., Blackburn, C., Blackman, J., Blackman, K., Blanchard, T. R., Blatchford, P., Bobkov, P., Boboc, V., Bodnã¡r, A., Bogar, G., Bolshakova, O., Bolzonella, I., Tommaso, Bonanomi, Bonelli, N., Boom, F., Booth, J., Borba, J., Borodin, D., Borodkina, D., Botrugno, I., Bottereau, A., Boulting, C., Bourdelle, P., Bowden, C., Bower, M., Bowman, C., Boyce, C., Boyd, T., Boyer, C., Bradshaw, H. J., Braic, J. M. A., Bravanec, V., Breizman, R., Bremond, B., Brennan, S., Breton, P. D., Brett, S., Brezinsek, A., Bright, S., Brix, M. D. J., Broeckx, M., Brombin, W., Matteo, Broså‚awski, Brown, A., Brown, D. P. D., Bruno, M., Bucalossi, E., Buch, J., Buchanan, J., Buckley, J., Budny, M. A., Bufferand, R., Bulman, H., Bulmer, M., Bunting, N., Buratti, P., Burckhart, P., Buscarino, A., Busse, A., Butler, A., Bykov, N. K., Byrne, I., Cahyna, J., Calabrã², P., Calvo, G., Camenen, I., Camp, Y., Campling, P., Cane, D. C., Cannas, J., Capel, B., Card, A. J., Cardinali, P. J., Carman, A., Carr, P., Carralero, M., Carraro, D., Carvalho, L., Carvalho, B. B., Carvalho, I., Casson, P., Castaldo, F. J., Catarino, C., Caumont, N., Causa, J., Cavazzana, F., Cave, Ayland, Cavinato, K., Cecconello, M., Ceccuzzi, M., Cecil, S., Cenedese, E., Angelo, Cesario, Challis, R., Chandler, C. D., Chandra, M., Chang, D., Chankin, C. S., Chapman, A., Chapman, I. T., Chernyshova, S. C., Chitarin, M., Giuseppe, Ciraolo, Ciric, G., Citrin, D., Clairet, J., Clark, F., Clark, E., Clarkson, M., Clatworthy, R., Clements, D., Cleverly, C., Coad, M., Coates, J. P., Cobalt, P. A., Coccorese, A., Cocilovo, V., Coda, V., Coelho, S., Coenen, R., Coffey, J. W., Colas, I., Collins, L., Conka, S., Conroy, D., Conway, S., Coombs, N., Cooper, D., Corradino, S. R., Corre, C., Corrigan, Y., Cortes, G., Coster, S., Couchman, D., Cox, A. S., Craciunescu, M. P., Cramp, T., Craven, S., Crisanti, R., Croci, F., Croft, G., Crombã©, D., Crowe, K., Cruz, R., Cseh, N., Cufar, G., Cullen, A., Curuia, A., Czarnecka, M., Dabirikhah, A., Dalgliesh, H., Dalley, P., Dankowski, S., Darrow, J., Davies, D., Davis, O., Day, W., Day, C., I. E., Bock, De, Castro, De, De La Cal, De La Luna, Masi, De, Pablos, De, J. L., Temmerman, De, Tommasi, De, Vries, De, Deakin, P., Deane, K., Degli, Agostini, Dejarnac, F., Delabie, R., Den, Harder, Dendy, N., Denis, R. O., Denner, J., Devaux, P., Devynck, S., Maio, Di, Siena, Di, Troia, Di, Dinca, C., D'Inca, P., Ding, R., Dittmar, B., Doerk, T., Doerner, H., Donnã©, R. P., Dorling, T., S. E., Dormido, Canto, Doswon, S., Douai, S., Doyle, D., Drenik, P. T., Drewelow, A., Drews, P., Duckworth, P., Dumont, P. h., Dumortier, R., Dunai, P., Dunne, D., Äžuran, M., Durodiã©, I., Dutta, F., Duval, P., Dux, B. P., Dylst, R., Dzysiuk, K., Edappala, N., Edmond, P. V., Edwards, J., Edwards, A. M., Eich, J., Ekedahl, T. h., Jorf, El, Elsmore, R., Enachescu, C. G., Ericsson, M., Eriksson, G., Eriksson, F., Eriksson, J., Esposito, L. G., Esquembri, B., Esser, S., Esteve, H. G., Evans, D., Evans, B., Evison, G. E., Ewart, G., Fagan, G. D., Faitsch, D., Falie, M., Fanni, D., Fasoli, A., Faustin, A., Fawlk, J. M., Fazendeiro, N., Fedorczak, L., Felton, N., Fenton, R. C., Fernades, K., Fernandes, A., Ferreira, H., Fessey, J., Fã©vrier, J. 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F., Walker, N., Walker, M., Walsh, R., Wang, M., Wang, E., Warder, N., Warren, S., Waterhouse, R. J., Watkins, J., Watts, N. W., Wauters, C., Weckmann, T., Weiland, A., Weisen, J., Weiszflog, H., Wellstood, M., West, C., Wheatley, A. T., Whetham, M. R., Whitehead, S., Whitehead, A. M., Widdowson, B. D., Wiesen, A. M., Wilkinson, S., Williams, J., Wilson, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wischmeier, J., Withenshaw, M., Withycombe, G., Witts, A., Wood, D. M., Wood, D., Woodley, R., Wray, C., Wright, S., Wright, J., J. C., Wu, Wukitch, J., Wynn, S., Xu, A., Yadikin, T., Yanling, D., Yao, W., Yavorskij, L., Yoo, V., Young, M. G., Young, C., Young, D., Young, I. D., Zacks, R., Zagorski, J., Zaitsev, R., Zanino, F. S., Zarins, R., Zastrow, A., Zerbini, K. D., Zhang, M., Zhou, W., Zilli, Y., Zoita, E., Zoletnik, V., Zychor, S., I, and JET Contributors
- Subjects
Jet (fluid) ,Surface analysis ,Materials science ,Divertor ,JET-ILW ,Material deposition ,Material erosion ,Nuclear engineering ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,010305 fluids & plasmas ,13. Climate action ,Material Erosion ,0103 physical sciences ,Erosion ,010306 general physics ,Deposition (chemistry) ,Mathematical Physics - Abstract
Erosion of plasma-facing materials and successive transport and redeposition of eroded material are crucial processes determining the lifetime of plasma-facing components and the trapped tritium inventory in redeposited material layers. Erosion and deposition in the JET divertor were studied during the second JET ITER-like wall campaign ILW-2 in 2013-2014 by using a poloidal row of specially prepared divertor marker tiles including the tungsten bulk tile 5. The marker tiles were analyzed using elastic backscattering with 3-4.5 MeV incident protons and nuclear reaction analysis using 0.8-4.5 MeV 3He ions before and after the campaign. The erosion/deposition pattern observed during ILW-2 is qualitatively comparable to the first campaign ILW-1 in 2011-2012: deposits consist mainly of beryllium with 5-20 at.% of carbon and oxygen and small amounts of Ni and W. The highest deposition with deposited layer thicknesses up to 30 μm per campaign is still observed on the upper and horizontal parts of the inner divertor. Outer divertor tiles 5, 6, 7 and 8 are net W erosion areas. The observed D inventory is roughly comparable to the inventory observed during ILW-1. The results obtained during ILW-2 therefore confirm the positive results observed in ILW-1 with respect to reduced material deposition and hydrogen isotopes retention in the divertor.
- Published
- 2017
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16. Overview of fuel inventory in JET with the ITER-like wall
- Author
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Widdowson, A., Coad, J. P., Alves, E., Baron-Wiechec, A., Barradas, N. P., Brezinsek, S., Catarino, N., Corregidor, V., Heinola, K., Koivuranta, S., Krat, S., Lahtinen, A., Likonen, J., Matthews, G. F., Mayer, M., Petersson, P., Litaudon, Rubel M., Abduallev, X., Abhangi, S., Abreu, M., Afzal, P., Aggarwal, M., Ahlgren, K. M., Ahn, T., J. H., Aho, Mantila, Aiba, L., Airila, N., Albanese, M., Aldred, R., Alegre, V., Alessi, D., Aleynikov, E., Alfier, P., Alberto, Alkseev, Allinson, A., Alper, M., Alves, B., Ambrosino, E., Ambrosino, G., Amicucci, R., Amosov, L., Andersson, Sundã©n, Angelone, E., Anghel, M., Angioni, M., Appel, C., Appelbee, L., Arena, C., Ariola, P., Arnichand, M., Arshad, H., Ash, S., Ashikawa, A., Aslanyan, N., Asunta, V., Auriemma, O., Fulvio, Austin, Avotina, Y., Axton, L., Ayres, M. D., Bacharis, C., Baciero, M., Baiã¡o, A., Bailey, D., Baker, S., Balboa, A., Balden, I., Balshaw, M., Bament, N., Banks, R., Baranov, J. W., Barnard, Y. F., Barnes, M. 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F., Walker, N., Walker, M., Walsh, R., Wang, M., Wang, E., Warder, N., Warren, S., Waterhouse, R. J., Watkins, J., Watts, N. W., Wauters, C., Weckmann, T., Weiland, A., Weisen, J., Weiszflog, H., Wellstood, M., West, C., Wheatley, A. T., Whetham, M. R., Whitehead, S., Whitehead, A. M., Widdowson, B. D., Wiesen, A. M., Wilkinson, S., Williams, J., Wilson, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wischmeier, J., Withenshaw, M., Withycombe, G., Witts, A., Wood, D. M., Wood, D., Woodley, R., Wray, C., Wright, S., Wright, J., J. C., Wu, Wukitch, J., Wynn, S., Xu, A., Yadikin, T., Yanling, D., Yao, W., Yavorskij, L., Yoo, V., Young, M. G., Young, C., Young, D., Young, I. D., Zacks, R., Zagorski, J., Zaitsev, R., Zanino, F. S., Zarins, R., Zastrow, A., Zerbini, K. D., Zhang, M., Zhou, W., Zilli, Y., Zoita, E., Zoletnik, V., Zychor, S., I, and JET Contributors
- Subjects
Nuclear and High Energy Physics ,Jet (fluid) ,Hydrogen ,Plasma parameters ,JET ITER-like wall ,Divertor ,Nuclear engineering ,chemistry.chemical_element ,Condensed Matter Physics ,01 natural sciences ,fuel retention ,010305 fluids & plasmas ,material migration ,chemistry ,Sputtering ,visual_art ,0103 physical sciences ,visual_art.visual_art_medium ,Environmental science ,Tile ,010306 general physics - Abstract
Post mortem analyses of JET ITER-Like-Wall tiles and passive diagnostics have been completed after each of the first two campaigns (ILW-1 and ILW-2). They show that the global fuel inventory is still dominated by co-deposition; hence plasma parameters and sputtering processes affecting material migration influence the distribution of retained fuel. In particular, differences between results from the two campaigns may be attributed to a greater proportion of pulses run with strike points in the divertor corners, and having about 300 discharges in hydrogen at the end of ILW-2. Recessed and remote areas can contribute to fuel retention due to the larger areas involved, e.g. recessed main chamber walls, gaps in castellated Be main chamber tiles and material migration to remote divertor areas. The fuel retention and material migration due to the bulk W Tile 5 during ILW-1 are presented. Overall these tiles account for only a small percentage of the global accountancy for ILW-1.
- Published
- 2017
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17. MeV-range velocity-space tomography from gamma-ray and neutron emission spectrometry measurements at JET
- Author
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Salewski, M., Nocente, M., Jacobsen, A. S., Binda, F., Cazzaniga, C., Ericsson, G., Eriksson, J., Gorini, G., Hellesen, C., Hjalmarsson, A., Kiptily, V. G., Koskela, T., Korsholm, S. B., Kurki-Suonio, T., Leipold, F., Madsen, J., Moseev, D., Nielsen, S. K., Rasmussen, J., Schneider, M., Sharapov, S. E., Stejner, M., Litaudon, Tardocchi M., Abduallev, X., Abhangi, S., Abreu, M., Afzal, P., Aggarwal, M., Ahlgren, K. M., Ahn, T., J. H., Aho, Mantila, Aiba, L., Airila, N., Albanese, M., Aldred, R., Alegre, V., Alessi, D., Aleynikov, E., Alfier, P., Alberto, Alkseev, Allinson, A., Alper, M., Alves, B., Ambrosino, E., Ambrosino, G., Amicucci, R., Amosov, L., Andersson, Sundã©n, Angelone, E., Anghel, M., Angioni, M., Appel, C., Appelbee, L., Arena, C., Ariola, P., Arnichand, M., Arshad, H., Ash, S., Ashikawa, A., Aslanyan, N., Asunta, V., Auriemma, O., Fulvio, Austin, Avotina, Y., Axton, L., Ayres, M. D., Bacharis, C., Baciero, M., Baiã¡o, A., Bailey, D., Baker, S., Balboa, A., Balden, I., Balshaw, M., Bament, N., Banks, R., Baranov, J. W., Barnard, Y. F., Barnes, M. A., Barnes, D., Barnsley, M., Baron, Wiechec, Barrera, Orte, Baruzzo, L., Matteo, Basiuk, Bassan, V., Bastow, M., Batista, R., Batistoni, A., Baughan, P., Bauvir, R., Baylor, B., Bazylev, L., Beal, B., Beaumont, J., Beckers, P. S., Beckett, M., Becoulet, B., Bekris, A., Beldishevski, N., Bell, M., Belli, K., Bellinger, F., Belonohy, M., Ben, Ayed, Benterman, N., Bergsã¥ker, N. A., Bernardo, H., Bernert, J., Berry, M., Bertalot, M., Besliu, L., Beurskens, C., Bieg, M., Bielecki, B., Biewer, J., Bigi, T., Bã¬lkovã¡, M., Binda, P., Bisoffi, F., Bizarro, A., Bjã¶rkas, J. P. S., Blackburn, C., Blackman, J., Blackman, K., Blanchard, T. 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- Subjects
Nuclear and High Energy Physics ,gamma-ray spectrometry ,Neutron emission ,Fluids & Plasmas ,Astrophysics::High Energy Astrophysical Phenomena ,Nuclear Theory ,01 natural sciences ,7. Clean energy ,Atomic ,010305 fluids & plasmas ,Ion ,Nuclear physics ,Particle and Plasma Physics ,Physics::Plasma Physics ,0103 physical sciences ,fast ion ,γ-ray spectrometry ,Neutron ,Nuclear ,Emission spectrum ,fast ions ,010306 general physics ,Nuclear Experiment ,tokamak ,Nuclear and High Energy Physic ,Physics ,Jet (fluid) ,Neutron stimulated emission computed tomography ,Gamma ray ,Molecular ,neutron emission spectrometry ,velocity-space tomography ,Condensed Matter Physics ,Physics::Accelerator Physics ,Atomic physics ,Ion cyclotron resonance - Abstract
© 2017 Technical University of Denmark. We demonstrate the measurement of a 2D MeV-range ion velocity distribution function by velocity-space tomography at JET. Deuterium ions were accelerated into the MeV-range by third harmonic ion cyclotron resonance heating. We made measurements with three neutron emission spectrometers and a high-resolution γ-ray spectrometer detecting the γ-rays released in two reactions. The tomographic inversion based on these five spectra is in excellent agreement with numerical simulations with the ASCOT-RFOF and the SPOT-RFOF codes. The length of the measured fast-ion tail corroborates the prediction that very few particles are accelerated above 2 MeV due to the weak wave-particle interaction at higher energies.
- Published
- 2017
- Full Text
- View/download PDF
18. CTNNB1-mutated melanocytic lesions with DPN like features: a distinct subtype of melanocytic tumors? A report of two cases
- Author
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Teunissen, B. T., primary, Knuiman, G. J., additional, Eijkelenboom, A., additional, Wauters, C. A. P., additional, Wouda, S., additional, and Blokx, W. A. M., additional
- Published
- 2017
- Full Text
- View/download PDF
19. Auditsoftware onder de loep
- Author
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van der Pijl, GJ (Gert), Wauters, C, and Business Economics
- Published
- 2006
20. Sentinel lymph node biopsy can be omitted in DCIS patients treated with breast conserving therapy.
- Author
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Roozendaal, L., Goorts, B., Klinkert, M., Keymeulen, K., Vries, B., Strobbe, L., Wauters, C., Riet, Y., Degreef, E., Rutgers, E., Wesseling, J., and Smidt, M.
- Abstract
Breast cancer guidelines advise sentinel lymph node biopsy (SLNB) in patients with ductal carcinoma in situ (DCIS) on core biopsy at high risk of invasive cancer or in case of mastectomy. This study investigates the incidence of SLNB and SLN metastases and the relevance of indications in guidelines and literature to perform SLNB in order to validate whether SLNB is justified in patients with DCIS on core biopsy in current era. Clinically node negative patients diagnosed from 2004 to 2013 with only DCIS on core needle biopsy were selected from a national database. Incidence of SLN biopsy and metastases was calculated. With Fisher exact tests correlation between SLNB indications and actual presence of SLN metastases was studied. Further, underestimation rate for invasive cancer and correlation with SLN metastases was analysed. 910 patients were included. SLNB was performed in 471 patients (51.8 %): 94.5 % had pN0, 3.0 % pN1mi and 2.5 % pN1. Patients undergoing mastectomy had 7 % SLN metastases versus 3.5 % for breast conserving surgery (BCS) ( p = 0.107). The only factors correlating to SLN metastases were smaller core needle size ( p = 0.01) and invasive cancer ( p < 0.001). Invasive cancer was detected in 16.7 % by histopathology with 15.6 % SLN metastases versus only 2 % in pure DCIS. SLNB showed metastases in 5.5 % of patients; 3.5 % in case of BCS (any histopathology) and 2 % when pure DCIS was found at definitive histopathology (BCS and mastectomy). Consequently, SLNB should no longer be performed in patients diagnosed with DCIS on core biopsy undergoing BCS. If definitive histopathology shows invasive cancer, SLNB can still be considered after initial surgery. [ABSTRACT FROM AUTHOR]
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- 2016
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21. Preoperative cytological and histological diagnosis of breast lesions: A critical review
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Kooistra, B., primary, Wauters, C., additional, Strobbe, L., additional, and Wobbes, T., additional
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- 2010
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22. ChemInform Abstract: Recovery of Bromine from Waste Gas-Phase Hydrogen Bromide Streams Using an Electrolytic Membrane.
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WAUTERS, C. N., primary and WINNICK, J., additional
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- 2010
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23. 383 Contribution of cytological CSF analysis to the management of patients with breast cancer; a retrospective analysis over two decades
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Wauters, C., primary, Poelen, J., additional, Strobbe, L., additional, and Wesseling, P., additional
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- 2010
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24. Everything You Always Wanted To Know about Core Wash Cytology in a Same-Day Breast Clinic * but Were Afraid To Ask.
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Wauters, C., primary, Sanders-Eras, M., additional, de Kievit-van der Heijden, I., additional, Venderink, D., additional, van Dijk Azn, R., additional, van den Wildenberg, F., additional, Kooistra, B., additional, and Strobbe, L., additional
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- 2009
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25. The diagnostic value of nipple discharge cytology in 618 consecutive patients
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Kooistra, B.W., primary, Wauters, C., additional, van de Ven, S., additional, and Strobbe, L., additional
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- 2009
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26. The effect of Chinese herbal medicines (CHM) on menopausal symptoms compared to hormone replacement therapy (HRT) and placebo
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Kwee, S.H., primary, Tan, H.H., additional, Marsman, A., additional, and Wauters, C., additional
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- 2007
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27. An unusual case of multiple endocrine neoplasia type 1 and the role of In-pentetreotide scintigraphy
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PONSSEN, H, primary, DEHERDER, W, additional, BONJER, H, additional, WAUTERS, C, additional, KRENNING, E, additional, and LAMBERTS, S, additional
- Published
- 1996
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28. Foreign Material in Postoperative Adhesions
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Luijendijk, R. W., primary, de Lange, D. C.D., additional, Wauters, C. C.A.P., additional, Hop, W. C.J., additional, Duron, J. J., additional, Pailler, J. L., additional, Camprodon, B. R., additional, Holmdahl, L., additional, van Geldorp, H. J., additional, and Jeekel, J., additional
- Published
- 1996
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29. Ultrasound-guided fine-needle aspiration of suspicious nodes in breast cancer patients; selecting patients with extensive nodal involvement.
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Wely, B., Wilt, J., Schout, P., Kooistra, B., Wauters, C., Venderinck, D., and Strobbe, L.
- Abstract
The aim of this study was to evaluate the value of Ultrasonography (US) guided fine-needle aspiration (FNA) of the axilla to identify breast cancer patients with extensive nodal involvement. A prospective database of breast cancer patients who underwent US-guided FNA of suspicious nodes, diagnosed between 2000 and 2007 was analyzed. Patients with a negative axillary US or C2 (benign) FNA result underwent SLNB. Patients with C5 (malignant) FNA result underwent axillary lymph node dissection (ALND). All SLNB positive patients underwent completion ALND. The number of positive nodes after ALND was documented and analyzed. A total of 1,448 patients were included. US sensitivity was 34.2 %, specificity was 96.2 % and the accuracy was 71.7 %. For US-guided FNA this was 89, 100 and 90.4 %, respectively. In 234/1,448 patients (16.2 %) US-guided FNA was performed. A total of 19/41 C2 patients (46.3 %) had a positive SLNB. A median of 1 (range 1-6) positive node was found. A median of 4 (range 1-30) positive nodes were found in 158 C5 patients. In 376/1,214 patients with a negative US, SLNB was positive. A median of 2 (range 1-38) positive nodes were found. There was a significant difference in nodal involvement between C5 and SLNB positive patients ( p = 0.043 and p < 0.0001, respectively). Ultrasound-guided FNA is a highly specific technique for detecting axillary metastases in breast cancer patients. Patients with US-guided FNA-diagnosed axillary metastases have significantly more involved nodes compared to SLNB positive patients. [ABSTRACT FROM AUTHOR]
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- 2013
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30. Isolation and partial characterization of an unusual human immunodeficiency retrovirus from two persons of west-central African origin
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De Leys, R, primary, Vanderborght, B, additional, Vanden Haesevelde, M, additional, Heyndrickx, L, additional, van Geel, A, additional, Wauters, C, additional, Bernaerts, R, additional, Saman, E, additional, Nijs, P, additional, and Willems, B, additional
- Published
- 1990
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31. Bilateral profound hearing loss due to meningeal carcinomatosis
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Wagemakers, M., Verhagen, W., Borne, B.v.d., Venderink, D., Wauters, C., and Strobbe, L.
- Abstract
Meningeal carcinomatosis (MC) is an uncommon form of metastasis of solid tumors. Hearing loss as the presenting symptom of MC is very uncommon. A patient with an esophageal signet ring cell carcinoma 3 years previously presented with sudden onset of profound hearing loss affecting both ears. He had no evidence of local tumor recurrence. Brain magnetic resonance imaging (MRI) showed swelling and increased signal intensity on T2 weighted images of both acoustic nerves and the right trigeminal nerve. After gadolinium administration, enhancement of both acoustic and trigeminal nerves was seen. He later developed unsteadiness and head-movement-dependent oscillopsia due to vestibular areflexia and diplopia. At that time MRI showed leptomeningeal enhancement. MC was diagnosed, although cerebrospinal fluid cytology could not confirm that diagnosis. The patient died 16 weeks after the onset of deafness. In patients with progressive unilateral and bilateral hearing loss, meningeal carcinomatosis should be considered, especially if there is a history of previous malignancy.
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- 2005
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32. Testicular Granulocytic Sarcoma without Systemic Leukemia.
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Lagerveld, B. W., Wauters, C. A. P., and Karthaus, H. F. M.
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- *
SARCOMA , *MYELOID sarcoma , *LEUKEMIA , *DRUG therapy , *MYELOID leukemia - Abstract
This case report describes a unilateral testicular granulocytic sarcoma or chloroma. Because of the relatively immature nature of the tumor cells, the histological diagnosis can be difficult. Granulocytic sarcomas are well known in patients with systemic leukemia and can sometimes precede a systemic leukemic outcome. A solitary granulocytic sarcoma not followed by a hematological proliferation of the myelocytic stem cells is very rare. No prognostic factors that are able to predict a systemic outcome are known. Therefore, in this case with no signs of systemic disease, we adopted a wait-and-see policy after radical orchidectomy. Up to now, after a follow-up period of 7 years, the patient is still free of disease. Diagnosis and therapy of this urologic disease are discussed and the literature is reviewed. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2005
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33. Infection Familiale A Yersinia Enterocolitica
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Craux, Ch., primary and Wauters, C., additional
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- 1966
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34. ChemInform Abstract: Recovery of Bromine from Waste Gas-Phase Hydrogen Bromide Streams Using an Electrolytic Membrane.
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WAUTERS, C. N. and WINNICK, J.
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- 1996
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35. Unexpected borderline malignant and malignant smooth muscle cell tumors of the uterine corpus in women with LH-RH analogues
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Wauters, C. C. A. P., Harmsel, B. W. A. Ter, Hermans, M. P. M., and Smedts, F.
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- 1995
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36. High-risk human papillomavirus detection in self-sampling compared to physician-taken smear in a responder population of the Dutch cervical screening: Results of the VERA study.
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Ketelaars, P J W, Bosgraaf, R P, Siebers, A G, Massuger, L F A G, van der Linden, J C, Wauters, C A P, Rahamat-Langendoen, J C, van den Brule, A J C, IntHout, J, Melchers, W J G, and Bekkers, R L M
- Subjects
- *
PAPILLOMAVIRUS disease diagnosis , *COLLECTION & preservation of biological specimens , *PAP test , *PAPILLOMAVIRUSES , *PHYSICIANS , *SELF-evaluation , *EARLY detection of cancer , *DIAGNOSIS ,CERVIX uteri tumors - Abstract
In 2017 the cervical cancer screening program in The Netherlands will be revised. Cervical smears will primarily be tested for the presence of high-risk human papillomavirus (hrHPV) instead of cytology, and vaginal self-sampling will be offered to non-responders. This includes a potential risk that part of the women who would otherwise opt for a cervical smear will wait for self-sampling. However, self-sampling for hrHPV in a responder population has never been studied yet. The aim of this study was to investigate the applicability and accuracy of self-sampling in detecting hrHPV in a screening responder population. A total of 2049 women, aged 30-60years, participating in the screening program in The Netherlands were included from April 2013 to May 2015. After they had their cervical smear taken, women self-collected a cervicovaginal sample with a brush-based device, the Evalyn Brush. Both the cervical smear and self-sample specimen were tested with the COBAS 4800 HPV platform. The hrHPV prevalence was 8.0% (95% CI 6.9-9.2) among the physician-taken samples, and 10.0% (95% CI 8.7-11.3) among the self-samples. There was 96.8% (95% CI 96.0-97.5) concordance of hrHPV prevalence between self-samples and physician-taken samples. Women in our study evaluated self-sampling as convenient (97.1%), user-friendly (98.5%), and 62.8% preferred self-sampling over a physician-taken sampling for the next screening round. In conclusion, self-sampling showed high concordance with physician-taken sampling for hrHPV detection in a responder screening population and highly acceptable to women. Implementation of HPV-self-sampling for the responder population as a primary screening tool may be considered. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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37. Flat Epithelial Atypia: Management and outcome in three Dutch teaching hospitals.
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Ghuijs, P. M., de Vries, B., Strobbe, L. J. A., van Deurzen, C. H. M., Heuts, E. M., Keymeulen, K. B. M. I., Lobbes, M. B. I., Wauters, C. A. P., Van de Vijver, K. K. B. T., and Smidt, M. L.
- Subjects
- *
BREAST cancer research , *EPITHELIAL cells , *MAMMOGRAMS , *DUCTAL carcinoma , *BREAST cancer risk factors - Abstract
Background: Flat Epithelial Atypia (FEA) is a presumably neoplastic alteration of terminal duct-lobular units, characterized by the replacement of native luminal epithelium by ductal cells demonstrating low-grade cytologic atypia. The architecture shows stratification of epithelial cells. FEA is often accompanied by microcalcifications and therefore discovered in biopsies following screening mammography. FEA is frequently seen in association with ADH (atypical ductal hyperplasia), DCIS (ductal carcinoma in situ), lobular neoplasia and invasive tubular carcinomas. There is emerging evidence suggesting FEA may represent a precursor to DCIS. The risk of subsequent breast carcinoma remains to be defined. The aim of this study is therefore to inventorise the management and outcome of solitary FEA in histological biopsies in three Dutch teaching hospitals. Materials and Methods: Data of this retrospective multicentre study were collected in a database. Local pathology databases were screened with the terms: 'FEA', 'Flat Epithelial Atypia', 'columnar atypia' and Dutch equivalents. Results were manually screened, only including solitary FEA. Patient files were viewed for information on presentation, mammography, ultrasound and management: surgery vs follow-up. In case of excision, definitive pathology was added. Results: We included 103 patients showing only solitary FEA in the primary biopsy. Management of these patients consisted of follow-up for 60 patients (58,3%) and surgery for 43 patients (41,7%, 49 excisions): lumpectomy (42) or mastectomy (7). Reason for choosing mastectomy was preventive in case of contralateral breast cancer or increased familial or genetic risk. Definitive pathology of lumpectomy or mastectomy showed no abnormalities or solitary FEA in 31 patients; other findings were ADH in 7, LCIS in 4 and DCIS in 7 patients. Some patients showed more than one finding. Invasive breast cancer (IBC) was detected in 3 patients. Only one mastectomy showed invasive disease, located in a different lobe, however. No incidents occurred in the follow-up group. Conclusions: No consistent management exists concerning solitary FEA in these three hospitals. Also, one hospital used the diagnosis of FEA inconsistently and interchangingly with other terms. Lack of this study is the retrospective gathering of data, making it difficult to detect the reasons for the chosen management. DCIS or IBC was discovered in 20,4% of all surgical specimens. It was concluded that FEA should be seen as a red flag, indicating the possible presence of a more malignant lesion. Additional research is warranted concerning long term follow-up for this patient group. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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38. Computer-Aided Assessment of Melanocytic Lesions by Means of a Mitosis Algorithm.
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Sturm B, Creytens D, Smits J, Ooms AHAG, Eijken E, Kurpershoek E, Küsters-Vandevelde HVN, Wauters C, Blokx WAM, and van der Laak JAWM
- Abstract
An increasing number of pathology laboratories are now fully digitised, using whole slide imaging (WSI) for routine diagnostics. WSI paves the road to use artificial intelligence (AI) that will play an increasing role in computer-aided diagnosis (CAD). In melanocytic skin lesions, the presence of a dermal mitosis may be an important clue for an intermediate or a malignant lesion and may indicate worse prognosis. In this study a mitosis algorithm primarily developed for breast carcinoma is applied to melanocytic skin lesions. This study aimed to assess whether the algorithm could be used in diagnosing melanocytic lesions, and to study the added value in diagnosing melanocytic lesions in a practical setting. WSI's of a set of hematoxylin and eosin (H&E) stained slides of 99 melanocytic lesions (35 nevi, 4 intermediate melanocytic lesions, and 60 malignant melanomas, including 10 nevoid melanomas), for which a consensus diagnosis was reached by three academic pathologists, were subjected to a mitosis algorithm based on AI. Two academic and six general pathologists specialized in dermatopathology examined the WSI cases two times, first without mitosis annotations and after a washout period of at least 2 months with mitosis annotations based on the algorithm. The algorithm indicated true mitosis in lesional cells, i.e., melanocytes, and non-lesional cells, i.e., mainly keratinocytes and inflammatory cells. A high number of false positive mitosis was indicated as well, comprising melanin pigment, sebaceous glands nuclei, and spindle cell nuclei such as stromal cells and neuroid differentiated melanocytes. All but one pathologist reported more often a dermal mitosis with the mitosis algorithm, which on a regular basis, was incorrectly attributed to mitoses from mainly inflammatory cells. The overall concordance of the pathologists with the consensus diagnosis for all cases excluding nevoid melanoma ( n = 89) appeared to be comparable with and without the use of AI (89% vs. 90%). However, the concordance increased by using AI in nevoid melanoma cases ( n = 10) (75% vs. 68%). This study showed that in general cases, pathologists perform similarly with the aid of a mitosis algorithm developed primarily for breast cancer. In nevoid melanoma cases, pathologists perform better with the algorithm. From this study, it can be learned that pathologists need to be aware of potential pitfalls using CAD on H&E slides, e.g., misinterpreting dermal mitoses in non-melanotic cells.
- Published
- 2022
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39. Omission of axillary lymph node dissection after neoadjuvant chemotherapy for clinically node-positive breast cancer: How can we select patients?
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van Zeeland M, Westhoff P, Wauters C, Bult P, Werner A, Laurens N, Strobbe L, and Meijer H
- Subjects
- Antineoplastic Combined Chemotherapy Protocols, Axilla, Chemotherapy, Adjuvant, Female, Humans, Lymph Node Excision, Lymph Nodes diagnostic imaging, Lymph Nodes surgery, Sentinel Lymph Node Biopsy, Breast Neoplasms drug therapy, Breast Neoplasms surgery, Neoadjuvant Therapy
- Published
- 2020
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40. Can Ex Vivo Magnetic Resonance Imaging of Rectal Cancer Specimens Improve the Mesorectal Lymph Node Yield for Pathological Examination?
- Author
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Stijns R, Philips B, Wauters C, de Wilt J, Nagtegaal I, and Scheenen T
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Neoplasm Staging, Prospective Studies, Lymph Nodes diagnostic imaging, Lymph Nodes pathology, Magnetic Resonance Imaging methods, Rectal Neoplasms diagnostic imaging, Rectal Neoplasms pathology
- Abstract
Purpose: The aim of this study was to use 7 T ex vivo magnetic resonance imaging (MRI) scans to determine the size of lymph nodes (LNs) in total mesorectal excision (TME) specimens and to increase the pathological yield of LNs with MR-guided pathology., Materials and Methods: Twenty-two fixated TME specimens containing adenocarcinoma were scanned on a 7 T preclinical MRI system with a T1-weighted 3-dimensional gradient echo sequence with frequency-selective lipid excitation (repetition time/echo time, 15/3 milliseconds; resolution, 0.293 mm) and a water-excited 3-dimensional multigradient echo (repetition time, 30 milliseconds; computed echo time, 6.2 milliseconds; resolution, 0.293 mm) pulse sequence.The first series of 11 TME specimens (S1) revealed the number and size of LNs on both ex vivo MRI and histopathology. The second series of 11 TME specimens (S2) was used to perform MR-guided pathology. The number, size, and percentages of yielded LNs of S1 and S2 were compared., Results: In all specimens (22/22), a median number of 34 LNs (interquartile range, 26-34) was revealed on ex vivo MRI compared with 14 LNs (interquartile range, 7.5-21.5) on histopathology (P = 0.003). Mean size of all LNs did not differ between the 2 series (ex vivo MRI: 2.4 vs 2.5 mm, P = 0.267; pathology: 3.6 vs 3.5 mm, P = 0.653). The median percentages of harvested LNs compared with nodes visible on ex vivo MRI per specimen for both series were not significantly different (40% vs 43%, P = 0.718). By using a size threshold of greater than 2 mm, the percentage improved to 71% (S1) and to 78% (S2, P = 0.895). The median number of harvested LNs per specimen did not increase by performing MR-guided pathology (S1, 14 LNs; S2, 20 LNs; P = 0.532)., Conclusions: Ex vivo MRI visualizes more LNs than (MR-guided) pathology is able to harvest. Current pathological examination was not further improved by MR guidance. The majority of LNs or LN-like structures visible on ex vivo MRI below 2 mm in size remain unexplained, which warrants a 3-dimensional approach for pathological reconstruction of specimens.
- Published
- 2019
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41. Validation of Whole-slide Digitally Imaged Melanocytic Lesions: Does Z-Stack Scanning Improve Diagnostic Accuracy?
- Author
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Sturm B, Creytens D, Cook MG, Smits J, van Dijk MCRF, Eijken E, Kurpershoek E, Küsters-Vandevelde HVN, Ooms AHAG, Wauters C, Blokx WAM, and van der Laak JAWM
- Abstract
Background: Accurate diagnosis of melanocytic lesions is challenging, even for expert pathologists. Nowadays, whole-slide imaging (WSI) is used for routine clinical pathology diagnosis in several laboratories. One of the limitations of WSI, as it is most often used, is the lack of a multiplanar focusing option. In this study, we aim to establish the diagnostic accuracy of WSI for melanocytic lesions and investigate the potential accuracy increase of z-stack scanning. Z-stack enables pathologists to use a software focus adjustment, comparable to the fine-focus knob of a conventional light microscope., Materials and Methods: Melanocytic lesions ( n = 102) were selected from our pathology archives: 35 nevi, 5 spitzoid tumors of unknown malignant potential, and 62 malignant melanomas, including 10 nevoid melanomas. All slides were scanned at a magnification comparable to use of a ×40 objective, in z-stack mode. A ground truth diagnosis was established on the glass slides by four academic dermatopathologists with a special interest in the diagnosis of melanoma. Six nonacademic surgical pathologists subspecialized in dermatopathology examined the cases by WSI., Results: An expert consensus diagnosis was achieved in 99 (97%) of cases. Concordance rates between surgical pathologists and the ground truth varied between 75% and 90%, excluding nevoid melanoma cases. Concordance rates of nevoid melanoma varied between 10% and 80%. Pathologists used the software focusing option in 7%-28% of cases, which in 1 case of nevoid melanoma resulted in correcting a misdiagnosis after finding a dermal mitosis., Conclusion: Diagnostic accuracy of melanocytic lesions based on glass slides and WSI is comparable with previous publications. A large variability in diagnostic accuracy of nevoid melanoma does exist. Our results show that z-stack scanning, in general, does not increase the diagnostic accuracy of melanocytic., Competing Interests: There are no conflicts of interest.
- Published
- 2019
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42. Whole-Slide Mitosis Detection in H&E Breast Histology Using PHH3 as a Reference to Train Distilled Stain-Invariant Convolutional Networks.
- Author
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Tellez D, Balkenhol M, Otte-Holler I, van de Loo R, Vogels R, Bult P, Wauters C, Vreuls W, Mol S, Karssemeijer N, Litjens G, van der Laak J, and Ciompi F
- Abstract
Manual counting of mitotic tumor cells in tissue sections constitutes one of the strongest prognostic markers for breast cancer. This procedure, however, is time-consuming and error-prone. We developed a method to automatically detect mitotic figures in breast cancer tissue sections based on convolutional neural networks (CNNs). Application of CNNs to hematoxylin and eosin (H&E) stained histological tissue sections is hampered by noisy and expensive reference standards established by pathologists, lack of generalization due to staining variation across laboratories, and high computational requirements needed to process gigapixel whole-slide images (WSIs). In this paper, we present a method to train and evaluate CNNs to specifically solve these issues in the context of mitosis detection in breast cancer WSIs. First, by combining image analysis of mitotic activity in phosphohistone-H3 restained slides and registration, we built a reference standard for mitosis detection in entire H&E WSIs requiring minimal manual annotation effort. Second, we designed a data augmentation strategy that creates diverse and realistic H&E stain variations by modifying H&E color channels directly. Using it during training combined with network ensembling resulted in a stain invariant mitosis detector. Third, we applied knowledge distillation to reduce the computational requirements of the mitosis detection ensemble with a negligible loss of performance. The system was trained in a single-center cohort and evaluated in an independent multicenter cohort from the cancer genome atlas on the three tasks of the tumor proliferation assessment challenge. We obtained a performance within the top three best methods for most of the tasks of the challenge.
- Published
- 2018
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43. 1399 H&E-stained sentinel lymph node sections of breast cancer patients: the CAMELYON dataset.
- Author
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Litjens G, Bandi P, Ehteshami Bejnordi B, Geessink O, Balkenhol M, Bult P, Halilovic A, Hermsen M, van de Loo R, Vogels R, Manson QF, Stathonikos N, Baidoshvili A, van Diest P, Wauters C, van Dijk M, and van der Laak J
- Subjects
- Algorithms, Female, Humans, Lymphatic Metastasis pathology, Neoplasm Staging, Breast Neoplasms pathology, Databases as Topic, Sentinel Lymph Node pathology, Staining and Labeling
- Abstract
Background: The presence of lymph node metastases is one of the most important factors in breast cancer prognosis. The most common way to assess regional lymph node status is the sentinel lymph node procedure. The sentinel lymph node is the most likely lymph node to contain metastasized cancer cells and is excised, histopathologically processed, and examined by a pathologist. This tedious examination process is time-consuming and can lead to small metastases being missed. However, recent advances in whole-slide imaging and machine learning have opened an avenue for analysis of digitized lymph node sections with computer algorithms. For example, convolutional neural networks, a type of machine-learning algorithm, can be used to automatically detect cancer metastases in lymph nodes with high accuracy. To train machine-learning models, large, well-curated datasets are needed., Results: We released a dataset of 1,399 annotated whole-slide images (WSIs) of lymph nodes, both with and without metastases, in 3 terabytes of data in the context of the CAMELYON16 and CAMELYON17 Grand Challenges. Slides were collected from five medical centers to cover a broad range of image appearance and staining variations. Each WSI has a slide-level label indicating whether it contains no metastases, macro-metastases, micro-metastases, or isolated tumor cells. Furthermore, for 209 WSIs, detailed hand-drawn contours for all metastases are provided. Last, open-source software tools to visualize and interact with the data have been made available., Conclusions: A unique dataset of annotated, whole-slide digital histopathology images has been provided with high potential for re-use.
- Published
- 2018
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44. Modified Core Wash Cytology: A reliable same day biopsy result for breast clinics.
- Author
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Bulte JP, Wauters CA, Duijm LE, de Wilt JH, and Strobbe LJ
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Breast Diseases diagnosis, Breast Diseases pathology, Breast Neoplasms diagnosis, Carcinoma, Ductal, Breast diagnosis, Carcinoma, Intraductal, Noninfiltrating diagnosis, Carcinoma, Lobular diagnosis, Cytological Techniques, Female, Fibroadenoma diagnosis, Humans, Image-Guided Biopsy, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Time Factors, Ultrasonography, Mammary, Young Adult, Biopsy, Large-Core Needle methods, Breast Neoplasms pathology, Carcinoma, Ductal, Breast pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Carcinoma, Lobular pathology, Fibroadenoma pathology
- Abstract
Background: Fine Needle Aspiration Biopsy (FNAB), Core Needle biopsy (CNB) and hybrid techniques including Core Wash Cytology (CWC) are available for same-day diagnosis in breast lesions. In CWC a washing of the biopsy core is processed for a provisional cytological diagnosis, after which the core is processed like a regular CNB. This study focuses on the reliability of CWC in daily practice., Methods: All consecutive CWC procedures performed in a referral breast centre between May 2009 and May 2012 were reviewed, correlating CWC results with the CNB result, definitive diagnosis after surgical resection and/or follow-up. Symptomatic as well as screen-detected lesions, undergoing CNB were included., Results: 1253 CWC procedures were performed. Definitive histology showed 849 (68%) malignant and 404 (32%) benign lesions. 80% of CWC procedures yielded a conclusive diagnosis: this percentage was higher amongst malignant lesions and lower for benign lesions: 89% and 62% respectively. Sensitivity and specificity of a conclusive CWC result were respectively 98.3% and 90.4%. The eventual incidence of malignancy in the cytological 'atypical' group (5%) was similar to the cytological 'benign' group (6%)., Conclusion: CWC can be used to make a reliable provisional diagnosis of breast lesions within the hour. The high probability of conclusive results in malignant lesions makes CWC well suited for high risk populations., (Copyright © 2016 Elsevier Ltd, BASO ~ the Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.)
- Published
- 2016
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45. Is the sentinel lymph node pathology protocol in breast cancer patients associated with the risk of regional recurrence?
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Bolster MJ, Pepels MJ, Wauters CA, Schapers RF, Meijer JW, Strobbe LJ, van Berlo CL, Klinkenbijl JH, Wobbes T, Voogd AC, Bult P, and Tjan-Heijnen VC
- Subjects
- Adult, Aged, Axilla, Female, Humans, Lymph Node Excision, Lymph Nodes pathology, Lymph Nodes surgery, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Prospective Studies, Risk Factors, Survival Rate, Breast Neoplasms pathology, Lymphatic Metastasis pathology, Sentinel Lymph Node Biopsy
- Abstract
Background: Internationally, there is no consensus on the pathology protocol to be used to examine the sentinel lymph node (SN) in breast cancer patients. Previously, we reported that ultra-staging led to more axillary lymph node dissections (ALND). The question was, whether ultra-staging is effective in reducing the risk of regional relapse., Methods: From January 2002 to July 2003, 541 patients from 4 hospitals were prospectively registered when they underwent a SN biopsy. In hospitals A, B, and C, 3 levels of the SN were examined pathologically, whereas in hospital D at least 7 additional levels were examined. Patients with a positive SN, including isolated tumor cells, underwent an ALND. This analysis focuses on the 341 patients with a negative SN. Primary endpoint was 5-year regional recurrence rate., Results: In hospital D 34% of the patients had a negative SN as compared to 71% in hospitals A, B, and C combined (p < 0.001). At 5 years follow-up, 9 (2.6%) patients had developed a regional lymph node relapse. In hospital D none of the patients had a regional recurrence, as compared to 9 (2.9%) cases of recurrence in hospitals A, B, and C., Conclusion: The less intensified SN pathology protocol appeared to be associated with a slightly increased risk of regional recurrence. The absolute risk was still less than 3%, and does not seem to justify the intensified SN pathology protocol of hospital D., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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46. "Axillary recurrences after sentinel lymph node biopsy: a multicentre analysis and follow-up of sentinel lymph node negative breast cancer patients".
- Author
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van Wely BJ, van den Wildenberg FJ, Gobardhan P, van Dalen T, Borel Rinkes IH, Theunissen EB, Wijsman JH, Ernst M, van der Pol CC, Madsen EV, Vles WJ, Wauters CA, de Wilt JH, and Strobbe LJ
- Subjects
- Adult, Aged, Axilla, Breast Neoplasms therapy, Cohort Studies, Combined Modality Therapy, Confidence Intervals, Databases, Factual, Disease-Free Survival, Female, Follow-Up Studies, Humans, Lymph Node Excision methods, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Odds Ratio, Prospective Studies, Risk Assessment, Sentinel Lymph Node Biopsy methods, Sentinel Lymph Node Biopsy statistics & numerical data, Survival Analysis, Treatment Outcome, Breast Neoplasms mortality, Breast Neoplasms pathology, Lymph Nodes pathology, Neoplasm Recurrence, Local etiology, Neoplasm Recurrence, Local mortality, Sentinel Lymph Node Biopsy adverse effects
- Abstract
Introduction: The objective of this study was to conduct a multicentre data analysis to identify prognostic factors for developing an axillary recurrence (AR) after negative sentinel lymph node biopsy (SLNB) in a large cohort of breast cancer patients with long follow-up., Patients and Methods: The prospective databases from different hospitals of clinically node negative breast cancer patients operated on between, 2000 and 2002 were analyzed. SLNB was performed and pathological analysis done by local pathologists according to national guidelines. Adjuvant treatment was given according to contemporary guidelines. Multivariate analysis was performed using all available variables, a p-value of <0,05 was considered to be significant., Results: A total of 929 patients who did not undergo axillary lymph node dissection were identified. After a median follow up of 77 (range 1-106) months, fifteen patients developed an isolated AR (AR rate 1,6%). Multivariate analysis showed that young age (p = 0.007) and the absence of radiotherapy (p = 0.010) significantly increased the risk of developing an AR. Distant metastasis free survival (DMFS) was significantly worse for patients with an AR compared to all other breast cancer patients (p < 0,0001)., Conclusion: Even after long-term follow up, the risk of developing an AR after a negative SLN in breast cancer is low. Young age and absence of radiation therapy are highly significant factors for developing an axillary recurrence. DMFS is worse for AR patients compared to patients initially diagnosed with N0 or N1 disease., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2012
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47. Modified core wash cytology (CWC), an asset in the diagnostic work-up of breast lesions.
- Author
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Wauters CA, Sanders-Eras MC, de Kievit-van der Heijden IM, Wesseling P, Venderink DJ, van Dijk Azn R, van den Wildenberg F, Kooistra BW, and Strobbe LJ
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, Ambulatory Care methods, Breast Diseases diagnosis, Breast Diseases pathology, Breast Diseases surgery, Breast Neoplasms diagnosis, Cohort Studies, Cytodiagnosis methods, Diagnosis, Differential, Female, Hospitals, Teaching, Humans, Immunohistochemistry, Middle Aged, Neoplasm Staging, Netherlands, Preoperative Care methods, Reproducibility of Results, Risk Assessment, Sensitivity and Specificity, Biopsy, Needle methods, Breast Neoplasms pathology, Neoplasm Invasiveness pathology
- Abstract
Aim: A quick and reliable preliminary diagnosis is essential in the management of a same-day breast clinic. In a preclinical study we developed an alternative method of core wash cytology (CWC). This study is an evaluation of this new CWC method introduced into the clinical setting., Methods: From April 2008 to April 2009, biopsies were taken from lesions in the breast. CWC was obtained from core needle biopsy (CNB) with a modified technique and classified into the categories: malignant, suspicious for malignancy, atypical, benign and inadequate. CWC and CNB diagnoses were correlated with the histopathology of subsequently obtained resection specimens. The sensitivity and specificity were calculated., Results: CWC was obtained from 226 breast lesions. In 167 of these cases subsequent resection of the lesion was performed revealing 149 carcinomas and 18 benign lesions. Of the 149 malignant cases, 136 were considered as either malignant or suspicious for malignancy by CWC, 7 as atypical, 4 as benign and 2 as inadequate. None of the 18 benign lesions were classified as suspicious or malignant on CWC. Eight out of 149 resected carcinomas were not recognized as malignant by histological analysis of the CNB, while 7 of these cases the CWC was considered malignant. The sensitivity and specificity were 97% and 100%, respectively., Conclusions: In the vast majority of patients the modified CWC technique can provide a quick and reliable diagnosis of malignant breast lesions. Furthermore, combining CWC with CNB histology can improve adequate, preoperative recognition of the malignant character of breast lesions., (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Published
- 2010
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48. Indeterminate breast fine-needle aspiration: repeat aspiration or core needle biopsy?
- Author
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Kooistra B, Wauters C, and Strobbe L
- Subjects
- Biopsy, Fine-Needle, Biopsy, Needle, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasm Staging, Prognosis, Retrospective Studies, Breast Neoplasms pathology, Carcinoma in Situ pathology, Carcinoma, Ductal, Breast pathology, Carcinoma, Lobular pathology
- Abstract
Fine-needle aspiration (FNA) of breast lesions provides indeterminate (C1, C3, and C4) diagnoses in a high proportion of cases. The aim of the present study was to retrospectively determine whether repeat FNA or core needle biopsy (CNB) most frequently provides a correct and more conclusive diagnosis. All patients who had an indeterminate primary FNA followed by repeat FNA or CNB within 1 month from 1992 to 2007 were included. FNA was diagnosed as C1-C5; CNB was diagnosed as B1-B5. Improvement in preoperative diagnosis by repeat FNA or CNB was defined as C2/B2 in benign lesions, C3/B3 in premalignant lesions, C4/B4 or C5/B5 in malignant lesions where primary FNA was C1, and C5/B5 in malignant lesions where primary FNA was C3 or C4. Among 255 eligible cases, CNB improved the preoperative diagnosis more often than did repeat FNA (78.0% vs. 54.8%, odds ratio = 2.9, P < .001). When corrected for patient age, appearance on mammogram (mass or not), clinical findings (palpable or not), tumor size, and aspiration mode (freehand vs. image guided), this difference slightly increased (odds ratio = 3.0, P = .001). CNB should be performed after an indeterminate FNA of a breast lesion to obtain a reliable and clear preoperative diagnosis.
- Published
- 2009
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49. [Granulomatous lobular mastitis: a benign abnormality that mimics malignancy].
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Vingerhoedt NM, Janssen S, Mravunac M, Wauters CA, and Strobbe LJ
- Subjects
- Adult, Anti-Inflammatory Agents therapeutic use, Azathioprine therapeutic use, Breast Neoplasms diagnosis, Breast Neoplasms drug therapy, Breast Neoplasms pathology, Cytodiagnosis, Diagnosis, Differential, Female, Granuloma pathology, Humans, Mastitis pathology, Middle Aged, Prednisone therapeutic use, Recurrence, Treatment Outcome, Granuloma diagnosis, Granuloma drug therapy, Mastitis diagnosis, Mastitis drug therapy
- Abstract
A palpable abnormality of the breast was found in three women, one aged 57 and two aged 41. The first two patients predominantly showed the characteristics of a purulent inflammation, and on mammogram the third patient appeared to have mastitis carcinomatosa. Histopathological investigation revealed a lobular, non-caseating granulomatous inflammation. They were treated with prednisone and the first and third patients also received azathioprine. After some time, the condition recurred in the contralateral breast in the second and third patients. Once again, medicinal treatment was given. When a palpable tumour of the breast is found the primary goal is to exclude malignancy. Granulomatous lobular mastitis is a rare and benign tumour of the breast that clinically mimics carcinoma. Often, conventional imaging does not lead to the diagnosis. A histological needle biopsy is the best way to reach a diagnosis. Immunosuppressive therapy is effective and is preferred over surgery.
- Published
- 2008
50. An unusual case of multiple endocrine neoplasia type 1 and the role of 111In-pentetreotide scintigraphy.
- Author
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Ponssen HH, de Herder WW, Bonjer HJ, Wauters CC, Krenning EP, and Lamberts SW
- Subjects
- Carcinoid Tumor diagnostic imaging, Carcinoid Tumor surgery, Female, Humans, Ileal Neoplasms surgery, Ileocecal Valve, Middle Aged, Radionuclide Imaging, Ileal Neoplasms diagnostic imaging, Indium Radioisotopes, Multiple Endocrine Neoplasia Type 1 diagnostic imaging, Somatostatin analogs & derivatives
- Abstract
A 50-year-old woman is described with a very unusual combination of MEN-1 syndrome with a negative family history. At first she had been treated because of a clinically non-functioning pituitary adenoma in the maxillary sinus. Six years later a carcinoid tumour was discovered by means of 111In-pentreotide scintigraphy.
- Published
- 1996
- Full Text
- View/download PDF
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