1. A Novel Anti-nucleocapsid Antibody Avidity Method for Identifying SARS-CoV-2 Reinfections.
- Author
-
Golding, Liam, Watts, Allison W, Shew, Jacob, Paramo, Marina Viñeta, Mâsse, Louise C, Goldfarb, David M, Abu-Raya, Bahaa, and Lavoie, Pascal M
- Subjects
- *
SARS-CoV-2 , *SARS-CoV-2 Omicron variant , *VIRAL transmission , *REINFECTION , *CONFIDENCE intervals - Abstract
Detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections is challenging with current serology assays and is further complicated by the marked decrease in routine viral testing practices as viral transmission increased during Omicron. Here, we provide proof-of-principle that high-avidity anti-nucleocapsid (N) antibodies detects reinfections after a single infection with higher specificity (85%; 95% confidence interval [95% CI], 80%–90%) compared to anti-N antibody levels (72%; 95% CI, 66%–79%) in a vaccinated cohort. This method could be used to retroactively investigate the epidemiology and incremental long-term health consequences of SARS-CoV-2 reinfections. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF