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1. Sarcoidosis developing after COVID‐19: A case report

Author

Dujrath Somboonviboon, Anan Wattanathum, Narumon Keorochana, and Kittisak Wongchansom

Subjects
COVID‐19, granulomatous, sarcoidosis, uveitis, Diseases of the respiratory system, RC705-779
Abstract

Abstract COVID‐19 has been implicated in the development of a range of autoimmune diseases and medical consequences. Sarcoidosis is an inflammatory disease with sustained granulomatous inflammation. The possible main pathogenesis of sarcoidosis is a dysregulation between immune response and certain environmental antigens. We present a case of sarcoidosis as an interesting sequela of COVID‐19. The patient was hospitalized due to SARS‐CoV‐2 without complication. Ten weeks after the illness, his chest computed tomography (CT) showed bilateral hilar, paratracheal and subcarinal lymph node enlargement. Endobronchial ultrasound with transbronchial needle aspiration (EBUS‐TBNA) was performed; pathologic findings were that of well‐formed non‐necrotizing granulomas. Complete eye examination reported panuveitis and papillitis in both eyes. On the basis of these findings, sarcoidosis was diagnosed. Therefore, sarcoidosis developing after COVID‐19 was suggested as a possible link between the viral infection and dysregulation of the inflammation process. However, further studies are needed to confirm this association.

Published
2022
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2. Pulmonary pseudoaneurysm presented as a lung nodule after recovering from Covid‐19 pneumonia

Author

Dujrath Somboonviboon and Anan Wattanathum

Subjects
Covid‐19, embolization, haemoptysis, pulmonary pseudoaneurysm, Diseases of the respiratory system, RC705-779
Abstract

Abstract Pulmonary pseudoaneurysms (PAPs) are an uncommon complication of severe acute respiratory syndrome coronavirus 2 infection, although they are a potentially life‐threatening condition. We present this interesting condition of severe coronavirus disease 2019 (Covid‐19) pneumonia. The patient presented with abnormal lung nodule and developed massive haemoptysis after recovering from Covid‐19 pneumonia. PAP was diagnosed by computed tomography angiography. Endovascular embolization was performed and the bleeding was stopped.

Published
2022
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3. Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis.

Author

Sutopa Talukdar, Vipa Thanachartwet, Varunee Desakorn, Supat Chamnanchanunt, Duangjai Sahassananda, Mukda Vangveeravong, Siripen Kalayanarooj, and Anan Wattanathum

Subjects
Medicine, Science
Abstract

Delayed plasma leakage recognition could lead to improper fluid administration resulting in dengue shock syndrome, subsequently, multi-organ failure, and death. This prospective observational study was conducted in Bangkok, Thailand, between March 2018 and February 2020 to determine predictors of plasma leakage and develop a plasma leakage predictive score among dengue patients aged ≥15 years. Of 667 confirmed dengue patients, 318 (47.7%) developed plasma leakage, and 349 (52.3%) had no plasma leakage. Multivariate analysis showed three independent factors associated with plasma leakage, including body mass index ≥25.0 kg/m2 (odds ratio [OR] = 1.784; 95% confidence interval [CI] = 1.040-3.057; P = 0.035), platelet count

Published
2021
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9. Serum Procalcitonin and Peripheral Venous Lactate for Predicting Dengue Shock and/or Organ Failure: A Prospective Observational Study.

Author

Vipa Thanachartwet, Varunee Desakorn, Duangjai Sahassananda, Akanitt Jittmittraphap, Nittha Oer-Areemitr, Sathaporn Osothsomboon, Manoon Surabotsophon, and Anan Wattanathum

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

BACKGROUND:Currently, there are no biomarkers that can predict the incidence of dengue shock and/or organ failure, although the early identification of risk factors is important in determining appropriate management to reduce mortality. Therefore, we sought to determine the factors associated with dengue shock and/or organ failure and to evaluate the prognostic value of serum procalcitonin (PCT) and peripheral venous lactate (PVL) levels as biomarkers of dengue shock and/or organ failure. METHODOLOGY/PRINCIPAL FINDINGS:A prospective observational study was conducted among adults hospitalized for confirmed viral dengue infection at the Hospital for Tropical Diseases in Bangkok, Thailand between October 2013 and July 2015. Data, including baseline characteristics, clinical parameters, laboratory findings, serum PCT and PVL levels, management, and outcomes, were recorded on pre-defined case report forms. Of 160 patients with dengue, 128 (80.0%) patients had dengue without shock or organ failure, whereas 32 (20.0%) patients developed dengue with shock and/or organ failure. Using a stepwise multivariate logistic regression analysis, PCT ≥0.7 ng/mL (odds ratio [OR]: 4.80; 95% confidence interval [CI]: 1.60-14.45; p = 0.005) and PVL ≥2.5 mmol/L (OR: 27.99, 95% CI: 8.47-92.53; p

Published
2016
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10. Dynamic Measurement of Hemodynamic Parameters and Cardiac Preload in Adults with Dengue: A Prospective Observational Study.

Author

Vipa Thanachartwet, Anan Wattanathum, Duangjai Sahassananda, Petch Wacharasint, Supat Chamnanchanunt, Ei Khine Kyaw, Akanitt Jittmittraphap, Mali Naksomphun, Manoon Surabotsophon, and Varunee Desakorn

Subjects
Medicine, Science
Abstract

Few previous studies have monitored hemodynamic parameters to determine the physiological process of dengue or examined inferior vena cava (IVC) parameters to assess cardiac preload during the clinical phase of dengue. From January 2013 to July 2015, we prospectively studied 162 hospitalized adults with confirmed dengue viral infection using non-invasive cardiac output monitoring and bedside ultrasonography to determine changes in hemodynamic and IVC parameters and identify the types of circulatory shock that occur in patients with dengue. Of 162 patients with dengue, 17 (10.5%) experienced dengue shock and 145 (89.5%) did not. In patients with shock, the mean arterial pressure was significantly lower on day 6 after fever onset (P = 0.045) and the pulse pressure was significantly lower between days 4 and 7 (P50% between days 4 and 5 (P

Published
2016
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12. Evaluating extravascular lung water in sepsis: Three lung-ultrasound techniques compared against transpulmonary thermodilution

Author

Pirompanich, Pattarin, Karakitsos, Dimitrios, Alharthy, Abdulrahman, Gillman, Lawrence, Blaivas, Michael, Buchanan, Brian, Brindley, Peter, and Wattanathum, Anan

Subjects
Lung -- Health aspects, Ultrasound imaging -- Usage -- Comparative analysis, Cardiac output -- Usage -- Comparative analysis, Sepsis -- Risk factors -- Diagnosis, Health
Abstract

Byline: Pattarin. Pirompanich, Dimitrios. Karakitsos, Abdulrahman. Alharthy, Lawrence. Gillman, Michael. Blaivas, Brian. Buchanan, Peter. Brindley, Anan. Wattanathum Background: Excessive extravascular lung water (EVLW) is associated with increased morbidity and mortality. [...]

Published
2018

17. Predictive model of return of spontaneous circulation among patients with out‐of‐hospital cardiac arrest in Thailand: The WATCH‐CPR Score

Author

Duangjai Sahassananda, Vipa Thanachartwet, Anan Wattanathum, Varunee Desakorn, Kumpol Amnuaypattanapon, Supat Chamnanchanunt, and Sasithon Pukrittayakamee

Subjects
Male, Emergency Medical Services, medicine.medical_specialty, medicine.medical_treatment, 030204 cardiovascular system & hematology, Return of spontaneous circulation, Odds, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Cardiopulmonary resuscitation, Prospective cohort study, Aged, Receiver operating characteristic, business.industry, Models, Cardiovascular, General Medicine, Emergency department, Middle Aged, Prognosis, Thailand, Cardiopulmonary Resuscitation, Patient Discharge, Confidence interval, Heart Arrest, Cardiology, Female, Observational study, business, Out-of-Hospital Cardiac Arrest
Abstract

BACKGROUND Out-of-hospital cardiac arrest is an emergency that requires immediate management to save lives. However, some predictive scores for the immediate outcomes of patients with out-of-hospital cardiac arrest are difficult to use in clinical practice. AIMS This study aimed to identify predictors of sustained return of spontaneous circulation and to develop a predictive score. METHODS This prospective observational study evaluated sustained return of spontaneous circulation among out-of-hospital cardiac arrest patients in a Thai emergency department between July 2014 and March 2018. The baseline characteristics and prehospital and hospital findings were analysed. RESULTS Of 347 patients, 126 (36.3%) had sustained return of spontaneous circulation and 20 (5.8%) were discharged. Witnessed arrest (odds ratio = 2.9, 95% confidence interval 1.3-6.2), time from arrest to chest compression

Published
2020

18. PREDICTED MALIGNANCY OF PULMONARY LESION BY USING TUMOR INSPECTOR VERSION 1 PROGRAM IN PHRAMONGKUTKLAO HOSPITAL

Author

Jutamas Dechsanga, Anan Wattanathum, Virisorn Wongsrichanalai, Kingpeth Promthong, Banphatree Khomkham, Rajalida Lapikorn, and Wannapon Suravorachet

Abstract

Background:Bronchoscopy for diagnosis had been performed for decade for tissue diagnosis. Pulmonary nodule can be originated from any caused, ranging from benign granuloma and infectious process to malignancy. Establishing the etiology of pulmonary nodule in accurate manner assumes critical importance, since surgical resection in a patient with early-stage lung cancer provides the highest chance of cure. By the same token, avoiding thoracic surgery for benign SPN whenever possible does obviate significant morbidity. At present Endobronchial ultrasound have been performed more often. The characteristic of endobronchial ultrasound with guide sheath can be predicted which pulmonary nodule could be benign or malignant in picture. There will be vary in interpreted outcome due to depending on pulmonologist’s experienced. We developed a tumor inspector program V.1 for helping to interpreted characteristic of endobronchial ultrasound picture which make it more stable, faster to interpreted and used for further treatment planning. Objective: To evaluate accuracy in interpretation characteristic endobronchial ultrasound picture of tumor inspector program V.1 compared with three pulmonology interventionists agreement. Methods:Cross-sectional study including patients who had pulmonary nodule that undergo EBUS-GS and obtained pathological tissue diagnosis. Results:Two hundred and eight patients were included in this study, mean age 61 years old were studied. One hundred and twenty-six (60.58%) were male. Thirty-four (16.35%) patients had history of smoking. Thirty-four patients (16.35%) had previous malignancy. In study we used pathological report as a gold standard. There were sensitivity 90.6% ,specificity 22.5% ,PPV 65.2%, NPV 60% and accuracy 64.42% in humans interpretation that compatible with pathological report. And there were sensitivity 90.0%%, specificity 81.2%, PPV 88.5% ,NPV 84.4% and accuracy 87.0% in version 1 tumor inspector program. Conclusions:In patients with pulmonary nodule, tumor inspector V.1 program had significantly higher specificity and accuracy to predict malignancy possibility than three pulmonology interventionists agreement.gram.

Published
2018

19. Evaluating Extravascular Lung Water in Sepsis: Three Lung-Ultrasound Techniques Compared against Transpulmonary Thermodilution

Author

Lawrence M. Gillman, Peter G. Brindley, Abdulrahman Alharthy, Anan Wattanathum, Dimitrios Karakitsos, Pattarin Pirompanich, Michael Blaivas, and Brian Buchanan

Subjects
ARDS, medicine.medical_specialty, Acute respiratory distress, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Sepsis, B-lines, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, In patient, Trial registration, lung ultrasound, business.industry, 030208 emergency & critical care medicine, respiratory system, medicine.disease, Pulmonary edema, Lung ultrasound, Lung water, extravascular lung water, Cardiology, transpulmonary thermodilution, Acute interstitial syndrome, business, Research Article
Abstract

Background: Excessive extravascular lung water (EVLW) is associated with increased morbidity and mortality. We compared three lung-ultrasound (L-US) techniques against the reference-standard transpulmonary thermodilution (TPTD) technique to access EVLW. Materials and Methods: This was a prospective, single-blind, cross-sectional study. Forty-four septic patients were enrolled. EVLW index was measured by the TPTD method, and an index of ≥10 mL/kg was considered diagnostic of pulmonary edema. EVLW index was then compared to three established bedside L-US protocols that evaluate sonographic B-lines: (1) a 28-zone protocol (total B-line score [TBS]) (2) a scanning 8-region examination, and (3) a 4-point examination. Results: Eighty-nine comparisons were obtained. A statistically significant positive correlation was found between L-US TBS and an EVLW index ≥10 mL/kg (r = 0.668,P < 0.001). The 28-zone protocol score ≥39 has a sensitivity of 81.6% and a specificity of 76.5% to define EVLW index ≥10 mL/kg. In contrast, the positive 4-point examination and scanning 8-regions showed low sensitivity (23.7% and 50.0%, respectively) but high specificity (96.1% and 88.2%, respectively). Ten patients with a total of 21 comparisons met criteria for acute respiratory distress syndrome (ARDS). In this subgroup, only the TBS had statistically significant positive correlation to EVLW (r = 0.488,P = 0.025). Conclusion: L-US is feasible in patients with severe sepsis. In addition, L-US 28-zone protocol demonstrated high specificity and better sensitivity than abbreviated 4- and 8-zone protocols. In ARDS, the L-US 28-zone protocol was more accurate than the 4- and 8-zone protocols in predicting EVLW. Consideration of limitations of the latter protocols may prevent clinicians from reaching premature conclusions regarding the prediction of EVLW. Trial Registration: ISRCTN11419081. Registered 4 February 2015 retrospectively.

Published
2018

20. FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia

Author

File, Thomas M., Jr, Low, Donald E., Eckburg, Paul B., Talbot, George H., Friedland, H. David, Lee, Jon, Llorens, Lily, Critchley, Ian A., Thye, Dirk A., Pullman, John, Giordano, Philip, Welker, James, Manos, Paul, Mehra, Purvi, File, Thomas, Jr, De Santo, Joseph, Venkateswaralu, Bhaskar, Gerald Schrock, Christian, Tillis, William, Winetz, Jan Alan, Gonzalez, J. Mario, Ramage, Anthony, Eisenhower, Dwight D., Koegelenberg, Coenie, Engelbrecht, Ingrid, Jurgens, Jaco, Mitha, Ishmail, Breedt, Johannes, Gani, Mashra, Roos, Johannes, Basson, Matthys, Van Zyl, Louis, Meeding, Ronel, Fulat, Muhammed, Le Roux, Marius, Bonvehi, Pablo Eduardo, Ganaha, Maria Cristina, Gurini, Ana Leticia, Daniel Lopardo, Gustavo, Cristina, Lucia, Edwardo Prieto, Sergio, Rodiguez, Claudia Gabriela, Augusto Teijeiro, Ricardo, Carmen Pallone, Elida, Pryluka, Daniel Horacio, da Cunha, Clovis Arns, da Silva, Nilton Brandao, de Faria Freire, Antonio Tarcisio, Ferreira Starling, Carlos Ernesto, Costa Fiterman, Jussara, Góngora Rubio, Fernando, Carlos Losso, Luis, Patelli, Maria, Souza Lima, Juliani, Zimermann Teixeira, Paulo José, Carmo Moreira, Maria Auxiliadora, Abreu de Oliveira, Julio César, Roudas, Vsevolod, Gamal, Evgeny A., Leschenko, Igor, Rudnov, Vladimir A., Yevdokimova, Anna G., Vertkin, Arkadiy L., Ambalov, Yuriy M., Dvoryashina, Irina V., Zilber, Elmira, Khamitov, Rustem F., Galustyan, Anna N., Reshetko, Olga V., Senior, Victoria Arama, Grosan, Mihaela Flavia, Jimborean, Gabriela, Lupse, Mihaela, Aron, Gheorgita, Olteanu, Dan, Puschita, Maria, Gavris, Claudia, Tudorache, Voicu Mircea, Youroukova, Vania, Petkova, Mila, Troshanova, Evelina, Dzhabalyan, Mari, Kavtaradze, George, Makhviladze, Manana, Tabukashvili, Revaz, Pons, Marco, Garbino, Jorge, Genne, Daniel, Rothen, Madeleine, de Saracho, Juan Oriz, Capelastegui, Alberto, Menendez, Rosario, Torres, Antoni, Shum, Conrado, Falco, Vincenç, Bouza, Emilio, Bru, Jean-Pierre, Misset, Benoit, Megarbane, Bruno, Sollet, Jean Pierre, Molina, Jean-Michel, Dalhoff, Klaus, Lorenz, Joachim, Petermann, Wolfgang, Rohde, Gernot, Schumann, Christian, Tasci, Selcuk, Zerbst, Joachim, Auch-Schwelk, Wolfgang, Suttorp, Norbert, Henrich, Rolf, Fertl, Andreas, Grohe, Christian, Jakobeit, Christian, Deppermann, Karl-Matthius, Batura-Gabryel, Halina, Pupek-Musialik, Danuta, Piotrowicz, Pawe, Marcisz, Czeslaw, Czarnobilski, Krzysztof, Jankowska, Renata, Janik, Krzysztof, Gutowska-Jablonska, Malgorzata, Hamankiewicz, Maciej, Kus, Jan, Rydzewski, Andrzej, Dulawa, Jan, Ziolko, Ewa, Baranska, Eliza, Wendland, Marian, Trebas-Pietras, Ewa, Tyszkiewic, Ireneusz, Bonelli, Johannes, Balikó, Zoltán, Bisits, Márta, Losonczy, Gyorgy, Mark, Zsuzsa, Albert, Istvan, Francovszky, Eva, Fonay, Karoly, Tetiana Pertseva, Tetiana, Yefimov, Volodymyr, Havrysyuk, Volodymyr, Melnyk, Vasyl, Yashyna, Lyudmyla, Monogarova, Nadiya, Kolchyn, Yuriy, Dutka, Roman, Smolyanyi, Oleksandr, Tryshchuk, Nadiya, Kaydashev, Igor, Rodionova, Victoria, Neyko, Vasyl, Chopey, Ivan, Alekniene, Birute, Kramilius, Ginataras, Naudziunas, Stanislovas, Miliauskas, Skaidrius, Nausediene, Vitalija, Valavicius, Arvydas, Mitic-Milikic, Marija, Celeketic, Dusica, Lazic, Zorica, Milinic, Nikola, Pejcic, Tatjana, Sukles, Kai, Jaanus, Martti, Meriste, Sulev, Ahmad Mahayiddin, Datin Hjh Aziah, Bin Abdul Muttalif, Abdul Pazak, Kuang Kiat, Kiew, Binte, Roslina, Manap, Abdul, bt Tarekh, Noor Aliza, Anekthananon, Thanomsak, Mootsikapun, Piroon, Intalapaporn, Poj, Pothirat, Chaicharn, Horsin, Pinyo, Churchottaworn, Charoen, Wattanathum, Anan, Dukat, Andrej, and Plutinsky, Jan

Published
2011
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24. Potential Development Model for Quality Control Personnel of Boiler Manufacturer

Author

Pariyasut Wattanathum, Somnuk Wisutthipat, Preeda Attawinijtrakan, and Taweesak Roopsing

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, business.industry, media_common.quotation_subject, Boiler (power generation), Focus group, Honesty, Analytical skill, Model development, Operations management, Business, Human resources, Welfare, Qualitative research, media_common
Abstract

The purposes of this research are to study the successful factor for quality control personnel in manufacturing of boiler industrials and to develop and evaluate a model of potential developing for quality control personnel in manufacturing of boiler industrials. This research was conducted under the method of quantitative and qualitative research. The qualitative research tool was informal questionnaires used for in-depth interview 10 boiler entrepreneurs and focus group with 15 professionals; a group of academician, a group of boiler entrepreneur and a group of Human Resources expert. The other tool was quantitative research using questionnaires which were designed for collecting primary data from 400 boiler entrepreneurs. The research statistics resulted in form of percentage, mean, standard deviation, and multiple regression analysis.The results of a model of potential developing for quality control personnel in manufacturing of boiler industrials that consisted of 3 core factors and 18 sub-factors. There are as follows: 1) operational skill consisted of 5 sub-factors; policies on quality control personnel improvement, role and duty of quality control personnel, role and duty of quality control personnel , career progress, team development, attitude for quality control personnel, 2) Managerial role consisted of 6 sub-factors; honesty and ethics on job, coordinate on job,earnestness on job, authority decision on job, compensation and welfare, performance in communicate, 3) knowledge consisted of 7 sub-factors; knowledge on job, continued work experiences, knowledge of boiler regulation and standard, training curriculum, analytic in problem solving, continued personnel improvement, analytical thinking. The results of model development and evaluation from focus group with experts found that Potential Development Model for Quality Control Personnel of Boiler Manufacturer will have been appropriate and possible to adopting various organizations.

Published
2019

30. COMPARATIVE STUDY OF SENSITIVITY BETWEEN THORACOSCOPY AND CT-GUIDED CLOSED PLEURAL BIOPSY FOR UNDIAGNOSED PLEURAL EFFUSION WITH DIFFERENT PLEURAL FEATURES

Author

A. Wattanathum and S. Kungsukool

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Pleural effusion, Thoracoscopy, Medicine, Radiology, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business, medicine.disease, Pleural biopsy
Published
2020

32. Peripheral pulmonary lesion classification from endobronchial ultrasonography images using weight-sum of upper and lower GLCM feature

Author

Rajalida Lipikorn, Banphatree Khomkham, and Anan Wattanathum

Subjects
Endobronchial ultrasonography, Computer science, business.industry, Feature extraction, Pattern recognition, Feature selection, 030218 nuclear medicine & medical imaging, Peripheral, Support vector machine, Lesion, Correlation, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, medicine, Entropy (information theory), Artificial intelligence, medicine.symptom, business
Abstract

This paper aims to classify a peripheral pulmonary lesion whether it is malignant or benign by proposing the new method to select a window of interest (WOI) using window slicing and the new feature called the "weight-sum of upper and lower gray level co-occurrence matrix (GLCM)" of an endobronchial ultrasound (EBUS) image. The proposed feature can be used to determine the heterogeneity of pulmonary lesion which is one of the most important characteristics of lung cancer. The proposed feature is used as input into three different feature selection methods and three different classifiers for lesion classification. In order to evaluate the classification, a set of 89 EBUS images were used as a sample set. The classifications were performed three times with three different sets of features that were extracted from sample images using the same classification process. The first set of features consists of only standard features which are mean, contrast, homogeneity, correlation, entropy, and energy. The second set of features consists of the proposed feature, and the last set of features consists of both standard features and the proposed feature. The classification results show that using genetic selection as feature selection method with support vector machine as classifier with only the proposed features as input data gives the highest accuracy rate. The statistical results show that the accuracy, the sensitivity, and the specificity are 84.27%, 82.53%, and 88.46%, respectively.

Published
2017

33. 37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3)

Author

Karavana, V., Smith, I., Kanellis, G., Sigala, I., Kinsella, T., Zakynthinos, S., Liu, L., Chen, J., Zhang, X., Liu, A., Guo, F., Liu, S., Yang, Y., Qiu, H., Grimaldi, D. G., Kaya, E., Acicbe, O., Kayaalp, I., Asar, S., Dogan, M., Eren, G., Hergunsel, O., Pavelescu, D., Grintescu, I., Mirea, L., Guanziroli, M., Gotti, M., Marino, A., Cressoni, M., Vergani, G., Chiurazzi, C., Chiumello, D., Gattinoni, L., Spano, S., Massaro, F., Moustakas, A., Johansson, S., Larsson, A., Perchiazzi, G., Zhang, X. W., Guo, F. M., Chen, J. X., Xue, M., Qiu, H. B., Yang, L., Fister, M., Knafelj, R., Suzer, M. A., Kavlak, M. E., Atalan, H. K., Gucyetmez, B., Cakar, N., Weller, D., Grootendorst, A. F., Dijkstra, A., Kuijper, T. M., Cleffken, B. I., Regli, A., De Keulenaer, B., Van Heerden, P., Hadfield, D., Hopkins, P. A., Penhaligon, B., Reid, F., Hart, N., Rafferty, G. F., Grasselli, G., Mauri, T., Lazzeri, M., Carlesso, E., Cambiaghi, B., Eronia, N., Maffezzini, E., Bronco, A., Abbruzzese, C., Rossi, N., Foti, G., Bellani, G., Pesenti, A., Bassi, G. Li, Panigada, M., Ranzani, O., Kolobow, T., Zanella, A., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Girardis, M., Barbagallo, M., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Torres, A., Ranzani, O. T., Umbrello, M., Taverna, M., Formenti, P., Mistraletti, G., Vetrone, F., Baisi, A., Garnero, A. G., Novotni, D. N., Arnal, J. A., Urner, M., Fan, E., Dres, M., Vorona, S., Brochard, L., Ferguson, N. D., Goligher, E. C., Leung, C., Joynt, G., Wong, W., Lee, A., Gomersall, C., Poels, S., Casaer, M., Schetz, M., Van den Berghe, G., Meyfroidt, G., Holzgraefe, B., Von Kobyletzki, L. B., Cianchi, G., Becherucci, F., Batacchi, S., Cozzolino, M., Franchi, F., Di Valvasone, S., Ferraro, M. C., Peris, A., Phiphitthanaban, H., Wacharasint, P., Wongsrichanalai, V., Lertamornpong, A., Pengpinij, O., Wattanathum, A., Oer-areemitr, N., Boddi, M., Cappellini, E., Ciapetti, M., Di Lascio, G., Bonizzoli, M., Lazzeri, C., Katsin, M. L., Hurava, M. Y., Dzyadzko, A. M., Hermann, A., Schellongowski, P., Bojic, A., Riss, K., Robak, O., Lamm, W., Sperr, W., Staudinger, T., Buoninsegni, L. Tadini, Parodo, J., Ottaviano, A., Cecci, L., Corsi, E., Ricca, V., de Garibay, A. Perez Ruiz, Ende-Schneider, B., Schreiber, C., Kreymann, B., Turani, F., Resta, M., Niro, D., Castaldi, P., Boscolo, G., Gonsales, G., Martini, S., Belli, A., Zamidei, L., Falco, M., Lamas, T., Mendes, J., Galazzi, A., Benco, B., Binda, F., Masciopinto, L., Lissoni, A., Adamini, I., Thamjamrassri, T., Watcharotayangul, J., Numthavaj, P., Kongsareepong, S., Higuera, J., Cabestrero, D., Rey, L., Narváez, G., Blandino, A., Aroca, M., Saéz, S., De Pablo, R., Mohamed, A., Sklar, M., Munshi, L., Alban, L., Turrini, C., Taccone, P., Marenghi, C., Spadaro, S., Volta, C., Alonso, D. Cabestrero, González, L. Rey, Franci, A., Stocchi, G., Cappuccini, G., Socci, F., Guetti, C., Rastrelli, P., Nestorowicz, A., Glapinski, J., Fijalkowska-Nestorowicz, A., Wosko, J., Duprez, F., Bonus, T., Cuvelier, G., Mashayekhi, S., Ollieuz, S., Reychler, G., Kuchyn, I., Bielka, K., Sergienko, A., Jones, H., Day, C., Park, S. C., Yeom, S. R., Myatra, S. N., Gupta, S., Rajnala, V., Divatia, J., Silva, J. Villalobos, Olvera, O. Aguilera, Schulte, R. Cavazos, Bermudez, M. Castañeda, Zorrilla, L. Pariente, Ferretis, H. Lopez, García, K. Trejo, Balciuniene, N., Ramsaite, J., Kriukelyte, O., Krikscionaitiene, A., Tamosuitis, T., Terragni, P., Brazzi, L., Falco, D., Pistidda, L., Magni, G., Bartoletti, L., Mascia, L., Filippini, C., Ranieri, V., Kyriakoudi, A., Rovina, N., Koltsida, O., Konstantellou, E., Kardara, M., Kostakou, E., Gavriilidis, G., Vasileiadis, I., Koulouris, N., Koutsoukou, A., Van Snippenburg, W., Kröner, A., Flim, M., Buise, M., Hemler, R., Spronk, P., Noffsinger, B., Singh, B., Hockings, L., Spina, C., Magni, F., Di Giambattista, C., Vargiolu, A., Citerio, G., Scaramuzzo, G., Waldmann, A. D., Böhm, S. H., Ragazzi, R., Volta, C. A., Heines, S. J., Strauch, U., Van de Poll, M. C., Roekaerts, P. M., Bergmans, D. C., Sosio, S., Gatti, S., Punzi, V., Asta, A., Mroczka, J., Yaroshetskiy, A. I, Rezepov, N. A., Mandel, I. A., Gelfand, B. R., Ozen, E., Karakoc, E., Ayyildiz, A., Kara, S., Ekemen, S., Yelken, B. Buyukkidan, Saasouh, W., Freeman, J., Turan, A., Hajjej, Z., Sellami, W., Bousselmi, M., Samoud, W., Gharsallah, H., Labbene, I., Ferjani, M., Vetrugno, L., Barbariol, F., Forfori, F., Regeni, I., Della Rocca, G., Jansen, D., Jonkman, A., Doorduin, J., Roesthuis, L., Van der Hoeven, J., Heunks, L., Marocco, S. Arrigoni, Bottiroli, M., Pinciroli, R., Galanti, V., Calini, A., Gagliardone, M., Fumagalli, R., Ippolito, D., Sala, V. L., Meroni, V., Elbanna, M., Nassar, Y., Abdelmohsen, A., Yahia, M., Mongodi, S., Mojoli, F., Via, G., Tavazzi, G., Fava, F., Pozzi, M., Iotti, G. A., Bouhemad, B., Ruiz-Ferron, F., Simón, J. Serrano, Gordillo-Resina, M., Chica-Saez, V., Garcia, M. Ruiz, Vela-Colmenero, R., Redondo-Orts, M., Gontijo-Coutinho, C., Ozahata, T., Nocera, P., Franci, D., Santos, T., Carvalho-Filho, M., Fochi, O., Nacoti, M., Signori, D., Bonacina, D., Bonanomi, E., Bonvecchio, E., Stella, A., Roldi, E., Orlando, A., Luperto, M., Trunfio, D., Licitra, G., Martinelli, R., Vannini, D., Giuliano, G., Näslund, E., Lindberg, L. G., Lund, I., Frithiof, R., Nichols, A., Pentakota, S., Kodali, B., Pranskunas, A., Kiudulaite, I., Simkiene, J., Damanskyte, D., Pranskuniene, Z., Arstikyte, J., Vaitkaitis, D., Pilvinis, V., Brazaitis, M., Pool, R., Haugaa, H., Botero, A., Escobar, D., Maberry, D., Tønnessen, T., Zuckerbraun, B., Pinsky, M., Gomez, H., Lyons, H., Trimmings, A., Domizi, R., Scorcella, C., Damiani, E., Pierantozzi, S., Tondi, S., Monaldi, V., Carletti, A., Zuccari, S., Adrario, E., Pelaia, P., Donati, A., Kazune, S., Grabovskis, A., Volceka, K., Rubins, U., Bol, M., Suverein, M., Delnoij, T., Driessen, R., Heines, S., Delhaas, T., Vd Poll, M., Sels, J., Jozwiak, M., Chambaz, M., Sentenac, P., Richard, C., Monnet, X., Teboul, J. L., Bitar, Z., Maadarani, O., Al Hamdan, R., Huber, W., Malbrain, M., Chew, M., Mallat, J., Tagami, T., Hundeshagen, S., Wolf, S., Mair, S., Schmid, R., Aron, J., Adlam, M., Dua, G., Mu, L., Chen, L., Yoon, J., Clermont, G., Dubrawski, A., Duhailib, Z., Al Assas, K., Shafquat, A., Salahuddin, N., Donaghy, J., Morgan, P., Valeanu, L., Stefan, M., Provenchere, S., Longrois, D., Shaw, A., Mythen, M. G., Shook, D., Hayashida, D., Munson, S. H., Sawyer, A., Mariyaselvam, M., Blunt, M., Young, P., Nakwan, N., Khwannimit, B., Checharoen, P., Berger, D., Moller, P., Bloechlinger, S., Bloch, A., Jakob, S., Takala, J., Van den Brule, J. M., Stolk, R., Vinke, E., Van Loon, L. M., Pickkers, P., Van der Hoeven, J. G., Kox, M., Hoedemaekers, C. W., Werner-Moller, P., Bertini, P., Guarracino, F., Colosimo, D., Gonnella, S., Brizzi, G., Mancino, G., Baldassarri, R., Pinsky, M. R., Amitrano, D., Goslar, T., Stajer, D., Radsel, P., De Vos, R., Dijk, N. Bussink-van, Stringari, G., Cogo, G., Devigili, A., Graziadei, M. Ceola, Bresadola, E., Lubli, P., Amella, S., Marani, F., Polati, E., Gottin, L., Colinas, L., Hernández, G., Vicho, R., Serna, M., Canabal, A., Cuena, R., Gimenez, J., Mercado, P., Depret, F., Sassi, K., Herner, A., Abded, N., Elghonemi, M., Monir, A., Nikhilesh, J., Apurv, T., Uber, A. U., Grossestreuer, A., Moskowitz, A., Patel, P., Holmberg, M. J., Donnino, M. W., Graham, C. A., Hung, K., Lo, R., Leung, L. Y., Lee, K. H., Yeung, C. Y., Chan, S. Y., Trembach, N., Zabolotskikh, I., Caldas, J., Panerai, R., Camara, L., Ferreira, G., Almeida, J., de Oliveira, G. Queiroz, Jardim, J., Bor-Seng-Shu, E., Lima, M., Nogueira, R., Jatene, F., Zeferino, S., Galas, F., Robinson, T., Hajjar, L. A., Oliveira, M., Norgueira, R., Groehs, R., Ferreira-Santos, L., Oliveira, G., Hajjar, L., Ribeiro, J., Gaiotto, F., Lisboa, L., Fukushima, J., Rizk, S., Osawa, E., Franco, R., Kalil, R., Chlabicz, M., Sobkowicz, B., Kaminski, K., Kazimierczyk, R., Musial, W., Tycińska, A., Siranovic, M., Gopcevic, A., Gavranovic, Z. G., Horvat, A. H., Krolo, H., Rode, B., Videc, L., Trifi, A., Abdellatif, S., Ismail, K. Ben, Bouattour, A., Daly, F., Nasri, R., Lakhal, S. Ben, Beurton, A., Girotto, V., Galarza, L., Guedj, T., Iliæ, M. Karaman, Sakic, L., NN, V., Stojcic, L., Alphonsine, J., Lai, C., Tapanwong, N., Chuntupama, P., Hoellthaler, J., Lahmer, T., Latham, H., Bengtson, C. D., Satterwhite, L., Stites, M., Simpson, S. Q., Skladzien, T., Cicio, M., Garlicki, J., Serednicki, W., Wordliczek, J., Vargas, P., Salazar, A., Espinoza, M., Graf, J., Kongpolprom, N., Sanguanwong, N., Jonnada, S., Gerrard, C., Jones, N., Morley, T., Thorburn, P. T., Musaeva, T., Horst, S., Lipcsey, M., Kawati, R., Pikwer, A., Rasmusson, J., Castegren, M., Shilova, A., Yafarova, A., Gilyarov, M., Stojiljkovic, D. L. Loncar, Ulici, A., Reidt, S., Lam, T., Jancik, J., Ragab, D., Taema, K., Farouk, W., Saad, M., Liu, X., Uber, A., Montissol, S., Donnino, M., Andersen, L. W., Perlikos, F., Lagiou, M., Papalois, A., Kroupis, C., Toumpoulis, I., Carter, D., Sardo, S., Landoni, G., Kongsayreepong, S., Sungsiri, R., Wongsripunetit, P., Marchio, P., Guerra-Ojeda, S., Gimeno-Raga, M., Mauricio, M. D., Valles, S. L., Aldasoro, C., Jorda, A., Aldasoro, M., Vila, J. M., Borg, U. B., Neitenbach, A. M., García, M., González, P. Guijo, Romero, M. Gracia, Orduña, P. Saludes, Cano, A. Gil, Rhodes, A., Grounds, R. M., Cecconi, M., Lee, C., Hatib, F., Jian, Z., Rinehart, J., De Los Santos, J., Canales, C., Cannesson, M., García, M. I. Monge, Scheeren, T., Chantziara, V., Vassi, A., Michaloudis, G., Sanidas, E., Golemati, S., Bateman, R. M., Mokhtar, A., Omar, W., Aziz, K. Abdel, El Azizy, H., Nielsen, D. L. Lykke, Holler, J. G., Lassen, A., Eriksson, M., Strandberg, G., Capoletto, C., Nakamura, R., Risk, S., Park, C., Dias, F., D’Arrigo, N., Fortuna, F., Redaelli, S., Zerman, L., Becker, L., Serrano, T., Cotes, L., Ramos, F., Fadel, L., Coelho, F., Mendes, C., Real, J., Pedron, B., Kuroki, M., Costa, E., and Azevedo, L.

Subjects
Critical Care and Intensive Care Medicine, Meeting Abstracts
Published
2017

34. 37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3)

Author

F. Barbariol, N. Koulouris, Matteo Pozzi, Fengmei Guo, Christian Richard, Gel'fand Br, A. Sergienko, Erica Adrario, G. Narváez, P. Wacharasint, V. Galanti, I. Labbene, M. Barbagallo, R. Hemler, M. Aroca, Z. Pranskuniene, E. Bresadola, D. Niro, N. Tapanwong, Claudia Scorcella, Elisa Damiani, M. W. Donnino, A. H. Horvat, G. Brizzi, Antonella Marino, Gustavo Ferreira, David H. Berger, S. P. Zeferino, A. Asta, M. R. Pinsky, P. Vargas, Anna Lee, V. Parrini, S. Sosio, J. Gimenez, H. Kandil, C. Y. Yeung, D. G. Grimaldi, S. Poels, M. Ferjani, C. Marenghi, E. Vinke, A. Ulici, S. Risk, V. Ricca, Michele Umbrello, P. Castaldi, V. Rajnala, A. Costa, A. Trifi, M. Serna, T. Apurv, M. Chew, Håkon Haugaa, C. Lai, S. Kongsayreepong, M. Stefan, D. Bonacina, Donald Maberry, I. Toumpoulis, M. Kardara, M. Chlabicz, T. Delnoij, G. Di Lascio, M. Lagiou, Vidas Pilvinis, R. Al Hamdan, A. Devigili, E. Karakoc, M. Gotti, Lars W. Andersen, M. Resta, Massimo Cressoni, L. Zerman, J. Chen, M. Bonizzoli, B. Pedron, Ronney B. Panerai, Guido Tavazzi, O. Koltsida, V. Wongsrichanalai, Luciano Gattinoni, M. Ciapetti, A. Bronco, A. Wattanathum, T. G. Robinson, S. Abdellatif, E. Maffezzini, V. Chica-Saez, Sophia Montissol, Xiaowen Liu, T. Ozahata, Alessia Vargiolu, D. Pavelescu, Geert Meyfroidt, C. Spina, M. Gimeno-Raga, P. V. Van Heerden, Paolo Pelaia, Fabio Guarracino, Luis Fernando Lisboa, S. Asar, Parth V. Patel, G. Kanellis, F. Magni, D. L. Lykke Nielsen, Tommaso Mauri, I. Kiudulaite, N.V. Trembach, J. Higuera, Peter Schellongowski, P. Radsel, L. Colinas, Julia Tizue Fukushima, T. Lam, G. Moise, D. Amitrano, S Martini, M. Stites, A. Lertamornpong, J. Arstikyte, J Ribeiro, A. Peris, Stefano Gatti, Jose Mª Vila, M. Brazaitis, M. C. Ferraro, C. Kroupis, J. Mroczka, M.I. Monge García, A. Herner, F. Dias, Giovanni Landoni, Martin Aldasoro, Diana Jansen, Dan Longrois, M. Castañeda Bermudez, C. Mendes, J. Garlicki, D. Trunfio, L. Masciopinto, S. Ollieuz, J. Hoellthaler, M. Bousselmi, Alexandra Beurton, E. Kaya, I. Kuchyn, M. Cozzolino, J. Serrano Simón, L. Videc, P. Lubli, Anders Larsson, Asta Krikscionaitiene, D. Stajer, M. A. Suzer, G. Hernández, T. Serrano, J. Jancik, Marta Lazzeri, Cornelia W. E. Hoedemaekers, Nawal Salahuddin, T. Morley, Mathieu Jozwiak, Jigeeshu V Divatia, P. Nocera, Peter E. Spronk, Laurent Brochard, D. Vannini, A. Carletti, W. Farouk, A. Kyriakoudi, B. Kreymann, Stefania Tondi, K. Kaminski, Annmarie Touborg Lassen, Napplika Kongpolprom, Czarina C. H. Leung, Xavier Monnet, Sheila Nainan Myatra, A. Abdelmohsen, M. Siranovic, A. Tycińska, A. Waldmann, Pablo Mercado, E. Konstantellou, N Rossi, Jean-Louis Teboul, J. Nikhilesh, D. Ippolito, R. Martinelli, R. Pinciroli, Juliano Pinheiro de Almeida, S. Mashayekhi, A. Botero, P. Werner-Moller, E. Näslund, Phillip A Hopkins, F. Marani, C. Gerrard, V. Nn, C. Filippini, G. Cuvelier, B. Ende-Schneider, F. Perlikos, Carlo Alberto Volta, Rafael Kawati, F. Ruiz-Ferron, J. Villalobos Silva, M. Sklar, S. Golemati, L. Mirea, O. Maadarani, G. Michaloudis, T. Bonus, F Galas, G. Vergani, Nicholas Hart, Katharina Riss, Jihad Mallat, O. R. Ranzani, F. Fortuna, M. Taverna, B L De Keulenaer, W. Serednicki, M. Chambaz, Roberta Domizi, L. Ferreira-Santos, N. Abded, L.B. von Kobyletzki, C. Aldasoro, François Dépret, S. Heines, N. A. Rezepov, A. Calini, Antonio Pesenti, T. Goslar, R. Groehs, R. Fumagalli, L. Gottin, S. Pentakota, M. Guanziroli, Paolo Formenti, M Falco, Gerrard F. Rafferty, AI Yaroshetskiy, P. Checharoen, R. Driessen, S. H. Munson, T. Skladzien, B. Kodali, P. Numthavaj, Baljit Singh, T. M. Kuijper, K. Abdel Aziz, G. Eren, M. Kuroki, S. Guerra-Ojeda, Marco Antonio de Carvalho-Filho, Eddy Fan, J. Mendes, K. Sassi, Z. G. Gavranovic, W. Sellami, R. Norgueira, Joseph Rinehart, J. Real, Giacomo Bellani, M. Yahia, C. Schreiber, S. Sardo, Paul J Young, L. Stojcic, G. Giuliano, HK Atalan, Paolo Taccone, Stephanie Itala Rizk, Jukka Takala, David Cabestrero, Manuel Ignacio Monge García, Thomas Staudinger, Antoni Torres, Valentina Girotto, Andrew Rhodes, G Van den Berghe, P. Rastrelli, G. Stocchi, Zhongping Jian, R. Vela-Colmenero, M. Van de Poll, Gaetano Perchiazzi, S. Reidt, A. Franci, Khaled M. Taema, R. Cavazos Schulte, Giacomo Grasselli, S. Johansson, K. Hung, M. R. Lima, I. Smith, C. Day, Xiwen Zhang, L. Hajjar, M. Eriksson, T. Kinsella, I. Vasileiadis, O. Acicbe, Andrius Pranskunas, Silvia Mongodi, Stefan Wolf, Giovanni Mistraletti, L Camara, Neringa Balciuniene, J. Freeman, J. De Los Santos, R. Lo, O. Fochi, A. Pikwer, A. Dijkstra, I. Regeni, N. Nakwan, Annemijn H. Jonkman, A. Papalois, D. N. Novotni, Nicola Jones, G. Cappuccini, F Turani, Miklos Lipcsey, L. Alban, A. Canabal, M. Buise, A. Nestorowicz, O. Hergunsel, G. Mercurio, H. Lopez Ferretis, A. G. Garnero, D. Signori, A. Zanella, A. Ayyildiz, D. Falco, E. Bor-Seng-Shu, Martin Urner, Tomas Tamosuitis, A. Trimmings, Eduardo L. V. Costa, A. M. Dzyadzko, W. Lamm, R Nakamura, Cecilia Turrini, Jonne Doorduin, Valentina Monaldi, S Ben Lakhal, Federico Franchi, K. Al Assas, K. H. Lee, Robert Frithiof, Luigi Vetrugno, F. Daly, T. Tagami, A. Turan, Giorgio Antonio Iotti, H. Latham, S. Livigni, R. Stolk, M. Nacoti, M. Luperto, G. Gavriilidis, H. Gharsallah, L. Bartoletti, I. Kayaalp, E. M. Roldi, Oliver Robak, R. Kalil, Gilles Clermont, N. D’Arrigo, M. Saad, J. Caldas, Laveena Munshi, Davide Chiumello, A. Koutsoukou, Cecilia Canales, Anne V. Grossestreuer, Colin A. Graham, H. Lyons, A. Blandino, D. Escobar, Stephan M. Jakob, F. Ramos, Michael P Casaer, L. Zamidei, I. Sigala, S. Kazune, C. A. Volta, F. Fava, B. Cambiaghi, J. Donaghy, R. Cuena, U. Strauch, Anita Orlando, Tobias Lahmer, S. Gonnella, G. Dua, L. Yang, Alexander Hermann, D. Shook, Lisen Emma Hockings, M. Boddi, Niall D. Ferguson, A. M. Neitenbach, T. Guedj, N. Eronia, Tor Inge Tønnessen, T. Lamas, D. Carter, Soraya L. Valles, T. Thamjamrassri, M. Gordillo-Resina, G. Salati, J Aron, Maurizio Cecconi, S Di Valvasone, A. Jorda, P. Guijo González, A. F. Grootendorst, O. T. Ranzani, A. Kröner, Lorenzo Berra, Rafael Alves Franco, G. Stringari, W. Saasouh, S. Hundeshagen, G. Queiroz de Oliveira, Gabriele Via, F. Socci, M. Malbrain, Jon Gitz Holler, V. Punzi, W. Samoud, Wolfgang Huber, Belaid Bouhemad, Y. Nassar, Uldis Rubins, J. Sels, Lisanne H Roesthuis, S. Y. Chan, H. Krolo, M. Cavana, Giuseppe Citerio, Mark Blunt, P. T. Thorburn, V. Meroni, I. Mandel, L. Sakic, W. Musial, M Mariyaselvam, J. Simkiene, J.G. van der Hoeven, L. Satterwhite, Martin Dres, Abele Donati, M. Cicio, J. Rasmusson, Mathias J Holmberg, E. Polati, M. D. Mauricio, M. Panigada, G. Magni, Thiago M Santos, B. I. Cleffken, K. Trejo García, M. L. Katsin, M. Ceola Graziadei, M. Gagliardone, F. Becherucci, Zouheir Ibrahim Bitar, F. Vetrone, Antonio Belli, C. Guetti, Azam Shafquat, A. Lissoni, V. Karavana, S. Horst, L. Cecci, G. Cogo, A. Mokhtar, J. Jardim, P. Morgan, C. Capoletto, L. Pistidda, Ling Yan Leung, C. Chiurazzi, I. Adamini, S. Batacchi, U. B. Borg, M. Suverein, Maxime Cannesson, Ling Liu, Gisele Queiroz de Oliveira, Dennis C J J Bergmans, E. Sanidas, L. Mu, W. Omar, Andrew D. Shaw, L. C. Chen, J. M. Van den Brule, M. Fister, M. Vd Poll, Chiara Abbruzzese, D. L. Loncar Stojiljkovic, P. Moller, B. Rode, N. Oer-areemitr, E. Bonvecchio, D. Franci, Silvia Pierantozzi, R. Baldassarri, S. Saéz, S. Amella, A. Fijalkowska-Nestorowicz, J.G van der Hoeven, Michael R. Pinsky, M. Elghonemi, M. Flim, Ewan C. Goligher, J. Graf, M. G. Mythen, Patricia Marchio, K. Ben Ismail, A Gil Cano, J. Watcharotayangul, S. C. Park, E. Ozen, M I Ruiz García, Eduardo A Osawa, M. Gilyarov, G. Gonsales, Brian S. Zuckerbraun, B. Benco, M. Bol, Markus Castegren, J. Glapinski, R Nasri, D. Hayashida, A. Moustakas, D. Damanskyte, O. Pengpinij, A. Baisi, S. Jonnada, S. Redaelli, M. Bottiroli, Theodor Kolobow, R. Nogueira, MA Oliveira, T. Delhaas, L. Rey González, A. Bouattour, Dinas Vaitkaitis, R. De Vos, R. Pool, D. Colosimo, I. Grintescu, F. Coelho, C. Di Giambattista, H. Phiphitthanaban, D. Cabestrero Alonso, H. El Azizy, T. Musaeva, D. Hadfield, M. Dogan, Francesco Forfori, S. Gupta, A. Salazar, A. Amatu, O. Kriukelyte, J. Parodo, N. Bussink-van Dijk, Wai T. Wong, E. Corsi, Filippo Binda, Fábio Biscegli Jatene, Michael W. Donnino, G. Licitra, B Yelken, A. Ottaviano, Haibo Qiu, Bethany Penhaligon, M. Elbanna, Ludhmila Abrahão Hajjar, M. Karaman Iliæ, R. De Pablo, G. Della Rocca, A. Mohamed, A. Shilova, Andris Grabovskis, Peter Pickkers, S. Kara, Z. Hajjej, S. Vorona, Miet Schetz, G. Mancino, C Park, D Ragab, S. Ekemen, Roland M. Schmid, Bülent Güçyetmez, Fiona Reid, M. Gracia Romero, Songqiao Liu, A. Sawyer, Ryon M. Bateman, G. Li Bassi, N. Rovina, Leo M. A. Heunks, M. Adlam, L. C. Azevedo, Eleonora Carlesso, J. A. Arnal, P. Terragni, B. Khwannimit, S. Spano, F. Massaro, A. Gopcevic, S. Provenchere, Laura Galarza, L. Pariente Zorrilla, Adrian Regli, C. D. Bengtson, A. Perez Ruiz de Garibay, P. Chuntupama, J. Babel, X. Zhang, Feras Hatib, M Espinoza, C. Gontijo-Coutinho, R. Kazimierczyk, M. Xue, L. Cotes, Hai Bo Qiu, S. Zakynthinos, E. Cappellini, A. Uber, L. Becker, H. Jones, L. Tadini Buoninsegni, A. U. Uber, Andrea Stella, C. Lee, O. Aguilera Olvera, R. Vicho, P. Bertini, E. Bonanomi, S. Kongsareepong, J. Alphonsine, F. Duprez, K. Volceka, P. M. Roekaerts, J. Ramsaite, A. Yafarova, Simone Lindau, J. X. Chen, Hernando Gomez, M. Redondo-Orts, Riccardo Ragazzi, I.B. Zabolotskikh, J. Wordliczek, L. Fadel, Charles D. Gomersall, Stefan Bloechlinger, W. Van Snippenburg, S. J. Heines, A. Monir, A. Vezzani, Samuele Zuccari, B. Noffsinger, Alessandro Galazzi, Joo Heung Yoon, P. Saludes Orduña, S. Böhm, Thomas Scheeren, Feng Mei Guo, Gavin M. Joynt, R. Sungsiri, S. Arrigoni Marocco, A. Nichols, B. Sobkowicz, L. G. Lindberg, A. Vassi, G. Cianchi, K. Bielka, Anja Bojic, Luciana Mascia, Massimo Girardis, P. Wongsripunetit, G. Boscolo, Ari Moskowitz, Yi Yang, Steven Q. Simpson, Vito Marco Ranieri, M. Kox, Airan Liu, C. Lazzeri, L. Brazzi, L. Rey, M. Y. Hurava, Z. Duhailib, Artur Dubrawski, Gaetano Scaramuzzo, Nahit Cakar, Giuseppe Foti, P. Sentenac, R. Knafelj, E. Kostakou, A. Bloch, I. Lund, Wolfgang R. Sperr, Francesco Mojoli, M. E. Kavlak, N. Sanguanwong, J. Wosko, L. Valeanu, V. L. Sala, B. Holzgraefe, G. Strandberg, L. M. Van Loon, F. Gaiotto, R. M. Grounds, S. R. Yeom, D. Weller, V. Chantziara, G. Reychler, S. Mair, Savino Spadaro, Karavana, V, Smith, I, Kanellis, G, Sigala, I, Kinsella, T, Zakynthinos, S, Liu, L, Chen, J, Zhang, X, Liu, A, Guo, F, Liu, S, Yang, Y, Qiu, H, Grimaldi, D, Kaya, E, Acicbe, O, Kayaalp, I, Asar, S, Dogan, M, and Citerio, G

Subjects
03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, Intensive care, Emergency medicine, Medicine, 030208 emergency & critical care medicine, intensive care medicine, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, business
Published
2017

36. Macrolide-resistantmycoplasma pneumoniaein respiratory tract infection and its clinical relevance

Author

Varunya Wutthichan, Pornanan Domthong, Sudaluck Tanyaharn, Virissorn Wongsrichanalai, Poonapong Hansiriphan, Uthumporn Domthong, Anan Wattanathum, and Patumporn Jian-umpunkul

Subjects
medicine.medical_specialty, Mycoplasma pneumoniae, Respiratory tract infections, business.industry, medicine.disease_cause, Gastroenterology, medicine.anatomical_structure, Levofloxacin, 23S ribosomal RNA, Internal medicine, Genotype, Immunology, Etiology, Medicine, Clinical significance, business, medicine.drug, Respiratory tract
Abstract

Mycoplasma pneumoniae (MP) is a common etiological agent of pneumonia.Emergence of macrolide-resistant MP(MRMP)is now being reported.This study aims to assess the differences in clinical consequences between infected patients with MRMP and macrolide-susceptible strains(MSMP).One hundred and sixteen MP strains were isolated from 1100 patients with respiratory tract infections by real-time PCR assay from February,2012 to April,2015.Gene sequencing analysis to detect point mutations in 23S rRNA conferring resistant genotypes was performed.Clinical characteristics and outcome of patients with MRMP and MSMP group were compared.Of 116 clinical isolates, 31 (26.7%) were resistant to macrolide.Of 30 MRMP strains harbored an A-to-G transition mutation at position 2063 in 23S rRNA genes and only one was mutated at position 2064.Clinical data were completely available for 104 patients, 25 of whom had infected with MRMP.Demographic data, clinical symptoms, leukocyte counts and chest film findings were similar between both groups.Infected patients with MRMP had history of antibiotic exposure before 3 months more than MSMP group(80% versus 34.2%;P 0.001).Rate of changes from initially prescribed antibiotic therapy to levofloxacin were high in MRMP group(40% versus 0%;P 0.003) and duration of symptom resolution after initiation of antibiotic therapy were longer for the MRMP group than MSMP group (6 days versus 3 days;P 0.01).Infected patients with MRMP have a history of antibiotic exposure, time to resolution of symptoms are significantly longer for those patients.Macrolide-treated patients who are infected with MP and no clinical improvement,levofloxacin is the alternative treatment.

Published
2016

37. Serum Procalcitonin and Peripheral Venous Lactate for Predicting Dengue Shock and/or Organ Failure: A Prospective Observational Study

Author

Manoon Surabotsophon, Varunee Desakorn, Anan Wattanathum, Sathaporn Osothsomboon, Duangjai Sahassananda, Nittha Oer-areemitr, Akanitt Jittmittraphap, and Vipa Thanachartwet

Subjects
Bacterial Diseases, Male, Viral Diseases, Physiology, Fevers, Dengue virus, medicine.disease_cause, Pathology and Laboratory Medicine, Biochemistry, Vascular Medicine, Procalcitonin, Dengue fever, Dengue Fever, 0302 clinical medicine, Mathematical and Statistical Techniques, Risk Factors, Medicine and Health Sciences, Odds Ratio, Medicine, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, lcsh:Public aspects of medicine, Incidence (epidemiology), Hematology, Middle Aged, Prognosis, Thailand, Clinical Laboratory Sciences, Body Fluids, Hospitalization, Clinical Laboratories, Infectious Diseases, Blood, Shock (circulatory), Physical Sciences, Regression Analysis, RNA, Viral, Female, medicine.symptom, Anatomy, Statistics (Mathematics), Research Article, Neglected Tropical Diseases, Adult, Calcitonin, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, Adolescent, lcsh:RC955-962, Multiple Organ Failure, 030231 tropical medicine, Hemorrhage, Research and Analysis Methods, Sensitivity and Specificity, Blood Plasma, 03 medical and health sciences, Young Adult, Signs and Symptoms, Diagnostic Medicine, Internal medicine, Humans, Lactic Acid, Severe Dengue, Statistical Methods, Aged, business.industry, Public Health, Environmental and Occupational Health, Biology and Life Sciences, lcsh:RA1-1270, Odds ratio, Dengue Virus, medicine.disease, bacterial infections and mycoses, Tropical Diseases, Confidence interval, Surgery, ROC Curve, business, Biomarkers, Mathematics
Abstract

Background Currently, there are no biomarkers that can predict the incidence of dengue shock and/or organ failure, although the early identification of risk factors is important in determining appropriate management to reduce mortality. Therefore, we sought to determine the factors associated with dengue shock and/or organ failure and to evaluate the prognostic value of serum procalcitonin (PCT) and peripheral venous lactate (PVL) levels as biomarkers of dengue shock and/or organ failure. Methodology/Principal Findings A prospective observational study was conducted among adults hospitalized for confirmed viral dengue infection at the Hospital for Tropical Diseases in Bangkok, Thailand between October 2013 and July 2015. Data, including baseline characteristics, clinical parameters, laboratory findings, serum PCT and PVL levels, management, and outcomes, were recorded on pre-defined case report forms. Of 160 patients with dengue, 128 (80.0%) patients had dengue without shock or organ failure, whereas 32 (20.0%) patients developed dengue with shock and/or organ failure. Using a stepwise multivariate logistic regression analysis, PCT ≥0.7 ng/mL (odds ratio [OR]: 4.80; 95% confidence interval [CI]: 1.60–14.45; p = 0.005) and PVL ≥2.5 mmol/L (OR: 27.99, 95% CI: 8.47–92.53; p, Author Summary Dengue is a major global health concern, particularly in tropical countries, and affects all age groups. Mortality rates among patients who have been hospitalized with severe dengue are 1.6–10.9%, and death in adults is mainly due to the development of dengue shock and organ dysfunction. In states of poor tissue circulation or shock, lactate is produced. Additionally, procalcitonin is a highly specific biomarker of systemic inflammation. Therefore, we assessed whether procalcitonin and peripheral venous lactate could be used to predict the incidence of dengue shock and/or organ failure in patients with dengue. Our study showed that a combination of serum procalcitonin levels ≥0.7 ng/mL and peripheral venous lactate levels ≥2.5 mmol/L at admission could discriminate between patients who did and did not develop shock and/or organ failure, with high sensitivity and specificity. These parameters may therefore be useful as prognostic biomarkers. Our results suggest that serum procalcitonin is indicative of an extensive early inflammatory response, which may occur during the systemic phase of dengue. Peripheral venous lactate may be produced as a result of the poor tissue circulation that precedes dengue shock. Our findings may help clinicians to predict dengue shock and/or organ failure earlier to reduce in-hospital mortality.

Published
2016

39. Identification of clinical factors associated with severe dengue among Thai adults: a prospective study

Author

Plengsakoon Suwannakudt, Nittha Oer-areemitr, Duangjai Sahassananda, Varunee Desakorn, Vipa Thanachartwet, Anan Wattanathum, Akanitt Jittmittraphap, and Supat Chamnanchanunt

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Vomiting, Hemorrhage, macromolecular substances, Dengue virus, Logistic regression, medicine.disease_cause, Dengue fever, Young Adult, Internal medicine, Odds Ratio, Medicine, Humans, Lactic Acid, Lymphocyte Count, Prospective Studies, Severe Dengue, Young adult, Prospective cohort study, Child, business.industry, Reverse Transcriptase Polymerase Chain Reaction, Age Factors, Odds ratio, Dengue Virus, Middle Aged, medicine.disease, Thailand, Infectious Diseases, Logistic Models, Tropical medicine, Immunology, Lactate, RNA, Viral, Female, Viral disease, business, Predictive factors, Research Article
Abstract

Background Dengue is the most common mosquito-borne viral disease in humans. Recently, there has been an epidemic shift of dengue from mainly affecting children to affecting more adults with increased severity. However, clinical factors associated with severe dengue in adults have varied widely between studies. We aimed to identify the clinical factors associated with the development of severe dengue according to the World Health Organization (WHO)’s 2009 definition. Methods We conducted a prospective study of adults with dengue admitted to the Hospital for Tropical Diseases in Bangkok, Thailand, from October 2012 to December 2014. Univariate and stepwise multivariate logistic regression analyses were performed. Results Of the 153 hospitalized patients with confirmed dengue viral infections, 132 (86.3 %) patients had non-severe dengue including dengue without warning signs (7 patients, 5.3 %) and dengue with warning signs (125, 94.7 %). The rest (21, 13.7 %) had severe dengue including severe plasma leakage (16, 76.2 %), severe organ involvement (16, 76.2 %), and severe clinical bleeding (8, 38.1 %). Using stepwise multivariate logistic regression, clinical factors identified as independently associated with the development of severe dengue were: (1) being >40 years old (odds ratio [OR]: 5.215, 95 % confidence interval [CI]: 1.538–17.689), (2) having persistent vomiting (OR: 4.817, CI: 1.375–16.873), (3) having >300 cells per μL of absolute atypical lymphocytes (OR: 3.163, CI: 1.017–9.834), and (4) having lactate levels ≥2.0 mmol/L (OR: 7.340, CI: 2.334–23.087). In addition, increases in lactate and absolute atypical lymphocyte levels corresponded with severe dengue (p

Published
2015

40. Prevalence and clinical significance of community-acquired penicillin-resistant pneumococcal pneumonia in Thailand

Author

Sudaluck Chantaratchada, Anan Wattanathum, Nonglak Chanthadisai, and Patchanee Sangthawan

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.drug_class, Penicillin Resistance, Antibiotics, Microbial Sensitivity Tests, medicine.disease_cause, Community-acquired pneumonia, Internal medicine, Streptococcus pneumoniae, medicine, Humans, Prospective Studies, Aged, Aged, 80 and over, business.industry, Ceftriaxone, Middle Aged, Pneumonia, Pneumococcal, Thailand, medicine.disease, Trimethoprim, Anti-Bacterial Agents, Community-Acquired Infections, Penicillin, Pneumonia, Multivariate Analysis, Immunology, Pneumococcal pneumonia, Female, business, medicine.drug
Abstract

Objective: The study aimed to evaluate the prevalence, clinical significance and outcome of community-acquired penicillin-resistant Streptococcus pneumoniae (PRSP) pneumonia in Thailand. Methodology: We conducted a prospective study in culture-proven pneumococcal pneumonia. Pneumococci were defined as susceptible, intermediate resistance and high resistance according to the definitions of the United States National Committee for Clinical Laboratory Standards (NCCLS). Results: Forty-six consecutive patients were enrolled. Of the S. pneumoniae isolates collected, 41.3% were resistant to penicillin (37% intermediate resistance and 4.3% high resistance). Resistance to other antibiotics was 13% to ceftriaxone (8.7% intermediate resistance and 4.3% high resistance), 34.8% to erythromycin, 39.1% to tetracycline, 26.1% to chloramphenicol, and 43.5% to trimethoprim -sulfamethoxazole. Prior antibiotic use within 3 months was significantly associated with resistance to penicillin. The overall mortality of pneumococcal pneumonia was 26.1%. Multilobar involvement and requirement for mechanical ventilation proved to be associated with mortality. However, resistance to penicillin or ceftriaxone was not associated with death. Conclusions: According to the US NCCLS guidelines, we found a high prevalence of drug-resistant S. pneumoniae in Thai patients with community-acquired pneumonia. Prior antibiotic use was significantly associated with penicillin resistance. However, the outcome was not related to in vitro penicillin susceptibility of S. pneumoniae isolated from the patients.

Published
2003

41. Community-Acquired Pneumonia in Southeast Asia

Author

Pongpun Nunthapisud, Nonglak Chanthadisai, Anon Jatakanon, Chutima Chaoprasong, Anan Wattanathum, Nukool Limpairojn, and Sudaluck Chantaratchada

Subjects
Pulmonary and Respiratory Medicine, Mycoplasma pneumoniae, medicine.medical_specialty, Chlamydia, biology, medicine.diagnostic_test, business.industry, Critical Care and Intensive Care Medicine, medicine.disease_cause, biology.organism_classification, medicine.disease, respiratory tract diseases, Serology, Microbiology, Pneumonia, Community-acquired pneumonia, Internal medicine, Streptococcus pneumoniae, medicine, Chlamydiaceae, Blood culture, Cardiology and Cardiovascular Medicine, business
Abstract

Study objectives: To determine microbial agents causing community-acquired pneumonia (CAP) in Southeast Asia. Design: A prospective study. Setting: Three general hospitals in Thailand. Patients: Two hundred forty-five adult patients fulfilling the clinical criteria of CAP from September 1998 to April 2001. Interventions: Investigations included sputum Gram stain and culture, blood culture, pleural fluid culture (if presented), urine antigen for Legionella pneumophila and Streptococcus pneumoniae , and serology for Mycoplasma pneumoniae , Chlamydia pneumoniae , and L pneumophila . Results: There were 98 outpatients and 147 hospitalized patients included in the study, and an organism was identified in 74 of 98 outpatients (75.5%) and 105 of 147 of the hospitalized patients (71.4%). C pneumoniae (36.7%), M pneumoniae (29.6%), and S pneumoniae (13.3%) were the most frequent causative pathogens found in outpatients, while S pneumoniae (22.4%) and C pneumoniae (16.3%) were the most common in hospitalized patients. There was a significantly higher incidence of C pneumoniae (36.7% vs 16.3%, respectively; p M pneumoniae (29.6% vs 6.8%; p S pneumoniae, L pneumophila , and mixed infections was not different between the groups. Mixed infections were presented in 13 of 98 outpatients (13.3%) and 9 of 147 hospitalized patients (6.1%), with C pneumoniae being the most frequent coinfecting pathogen. Conclusions: The data indicate that the core organisms causing CAP in Southeast Asia are not different from those in the Western countries. The guidelines for the treatment of patients with CAP, therefore, should be the same.

Published
2003

42. Cardiopulmonary monitoring in Thai ICUs (ICU-rESOURCE I Study)

Author

Kaweesak, Chittawatanarat, Anan, Wattanathum, Onuma, Chaiwat, and Chaweewan, Thongchai

Subjects
Cross-Sectional Studies, Critical Care, Health Care Surveys, Heart Function Tests, Humans, Practice Patterns, Physicians', Thailand, Monitoring, Physiologic, Respiratory Function Tests
Abstract

Cardiopulmonary monitoring (CPM) is rapidly progressing but data regarding CPM in Thai ICUs was unavailable. The objective of this study was to describe the situation, and gaps of CPM in Thai ICUs.Data were retrieved from the ICU-RESOURCE I study database survey CPM was divided into two aspects of device and measurement methods. These were categorized by device availability grading (AG), device availability per bed (DPB) and numeric frequency grading scale (FGS). Device availability was compared between academic and non-academic ICUs. Gap analysis of DPB and FGS was performed. Statistical significant difference was defined as p-value0.05.One hundred and fifty-five ICUs across Thailand participated in this study. Academic ICUs had significantly more devices available in new equipment with p0.05 (Vigilio, PiCCO, NICOM, esophageal pressure monitoring, transcutaneous PO2, electrical impedance tomography of lung) as well as measurement methods (stroke volume variation [SVV], pulse pressure variation [PPC], central venous oxygen saturation [ScvO2], lung mechanics). Most of new and higher technological devices had low density and few were available in all of Thai ICUs. However, in gap analysis, although these new devices and measurement techniques were available in ICUs, they were not frequently utilized.New technology devices of CPM had more availability in ACAD than in non-ACAD ICUs. Formal continuous training in new measurement methods should be established for reducing the availability and utilization gap (Thai Clinical Trial Registry: TCTR-201200005).

Published
2014

45. Dynamic Measurement of Hemodynamic Parameters and Cardiac Preload in Adults with Dengue: A Prospective Observational Study

Author

Thanachartwet, Vipa, primary, Wattanathum, Anan, additional, Sahassananda, Duangjai, additional, Wacharasint, Petch, additional, Chamnanchanunt, Supat, additional, Khine Kyaw, Ei, additional, Jittmittraphap, Akanitt, additional, Naksomphun, Mali, additional, Surabotsophon, Manoon, additional, and Desakorn, Varunee, additional

Published
2016
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47. Predicting fluid responsiveness in septic shock patients by using 3 dynamic indices: is it all equally effective?

Author

Petch, Wacharasint, Amornchai, Lertamornpong, Anan, Wattanathum, and Adisorn, Wongsa

Subjects
Male, Hemodynamics, Blood Pressure, Stroke Volume, Middle Aged, Sensitivity and Specificity, Shock, Septic, Plethysmography, Intensive Care Units, ROC Curve, Predictive Value of Tests, Fluid Therapy, Humans, Female, Oximetry, Prospective Studies
Abstract

To evaluate the effectiveness and accuracy of three dynamic indices, currently available in intensive care monitoring devices, which are pulse pressure variation (PPV), stroke volume variation (SVV) and pulse oximetry plethysmographic waveform variation (POPV) in septic patients.This prospective clinical trial was conducted in 20 deeply sedated septic patients 18 years of age and older who had invasive blood pressure monitoring with an intraarterial cannula. PPV, SVV and POPV (%) were calculated using five consecutive snapshots from every patient's monitor. Statistical analysis compared using linear regression, paired t-test or student t-test, and receiver operating characteristic (ROC) curve analysis.The authors found that, strong correlation existed of PPV for the detection of percent cardiac index change (r2 = 0.794, p0.001). A respiratory variation in POPV exceeding 14% (sensitivity of 72%, specificity of 90%), SVV exceeding 11% (sensitivity 90%, specificity 92%) allowed detection of PPV exceeding 12% (sensitivity 84%, specificity 96%).Comparing of PPV, SVV and POPV, PPV is the most correlate with percent change in cardiac index and the most effective dynamic index for predict fluid responsiveness in adult septic critically ill patients who are on controlled mechanical ventilator, followed by SVV and POPV.

Published
2012

48. Three dimensional lung nodule segmentation and estimation using thresholding on local thickness

Author

Anan Wattanathum, Nagul Cooharojananone, Rajalida Lipikorn, and Akaraphan Janetheerapong

Subjects
Nodule (geology), Computer science, business.industry, Feature extraction, Scale-space segmentation, Image processing, Image segmentation, engineering.material, Thresholding, Multispectral pattern recognition, engineering, Segmentation, Computer vision, Artificial intelligence, business
Abstract

A fast alternative user-selection procedure to semi-automatic Philips Extended Brilliance Workspace's Lung Nodule Assessment™ is presented. By using modified Local Thickness algorithm which utilizes 3D Region Growing algorithm and IsoData auto-thresholding algorithm, the user can perform fewer steps to semi-automatically segment and estimate a respective nodule more accurately, especially on irregular shape nodules. Attached blood vessels and extruding thorn-like features of the selected nodule are also automatically excluded in segmentation with the proposed method. By using correlation comparison on the same lung nodule dataset between our proposed method and Philips Extended Brilliance Workspace's Lung Nodule Assessment™'s semi-automatic method, we can see that the correlation is 0.9887.

Published
2012

49. Identification of clinical factors associated with severe dengue among Thai adults: a prospective study.

Author

Vipa Thanachartwet, Nittha Oer-areemitr, Supat Chamnanchanunt, Duangjai Sahassananda, Akanitt Jittmittraphap, Plengsakoon Suwannakudt, Varunee Desakorn, Anan Wattanathum, Thanachartwet, Vipa, Oer-Areemitr, Nittha, Chamnanchanunt, Supat, Sahassananda, Duangjai, Jittmittraphap, Akanitt, Suwannakudt, Plengsakoon, Desakorn, Varunee, and Wattanathum, Anan

Subjects
RNA analysis, AGE distribution, FLAVIVIRUSES, HEMORRHAGE, LACTIC acid, LONGITUDINAL method, POLYMERASE chain reaction, VOMITING, LOGISTIC regression analysis, REVERSE transcriptase polymerase chain reaction, DENGUE hemorrhagic fever, LYMPHOCYTE count, ODDS ratio, DIAGNOSIS
Abstract

Background: Dengue is the most common mosquito-borne viral disease in humans. Recently, there has been an epidemic shift of dengue from mainly affecting children to affecting more adults with increased severity. However, clinical factors associated with severe dengue in adults have varied widely between studies. We aimed to identify the clinical factors associated with the development of severe dengue according to the World Health Organization (WHO)'s 2009 definition.Methods: We conducted a prospective study of adults with dengue admitted to the Hospital for Tropical Diseases in Bangkok, Thailand, from October 2012 to December 2014. Univariate and stepwise multivariate logistic regression analyses were performed.Results: Of the 153 hospitalized patients with confirmed dengue viral infections, 132 (86.3 %) patients had non-severe dengue including dengue without warning signs (7 patients, 5.3 %) and dengue with warning signs (125, 94.7 %). The rest (21, 13.7 %) had severe dengue including severe plasma leakage (16, 76.2 %), severe organ involvement (16, 76.2 %), and severe clinical bleeding (8, 38.1 %). Using stepwise multivariate logistic regression, clinical factors identified as independently associated with the development of severe dengue were: (1) being >40 years old (odds ratio [OR]: 5.215, 95 % confidence interval [CI]: 1.538-17.689), (2) having persistent vomiting (OR: 4.817, CI: 1.375-16.873), (3) having >300 cells per μL of absolute atypical lymphocytes (OR: 3.163, CI: 1.017-9.834), and (4) having lactate levels ≥2.0 mmol/L (OR: 7.340, CI: 2.334-23.087). In addition, increases in lactate and absolute atypical lymphocyte levels corresponded with severe dengue (p < 0.05).Conclusions: Our study identified several clinical factors independently associated with the development of severe dengue among hospitalized adults with dengue. This can aid in the early recognition and prompt management of at-risk patients to reduce morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2015
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50. FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia

Author

Arkadiy L. Vertkin, Mihaela Flavia Grosan, Jorge Garbino, Irina V. Dvoryashina, Dirk Thye, Manana Makhviladze, Norbert Suttorp, Ivan Chopey, Dan Olteanu, Louis Van Zyl, Nadiya Tryshchuk, Rustem F. Khamitov, Ronel Meeding, Juan Oriz de Saracho, Lucia Cristina, Daniel Horacio Pryluka, Poj Intalapaporn, V Falcó, Noor Aliza bt Md Tarekh, Vitalija Nausediene, Fernando Gongora Rubio, Mashra Gani, Luis Carlos Losso, Sergio Edwardo Prieto, Klaus Dalhoff, Martti Jaanus, Evgeny A. Gamal, Pinyo Horsin, Tatjana Pejcic, Marco Pons, Zsuzsa Mark, Elmira Zilber, Lily Llorens, Jean-Pierre Bru, Nilton Brandao da Silva, Birute Alekniene, Paul B. Eckburg, Karl-Matthius Deppermann, Vasyl Neyko, Elida Carmen Pallone, Daniel Genne, Jussara Costa Fiterman, Bruno Mégarbane, Ingrid Engelbrecht, Renata Jankowska, Antoni Torres, Madeleine Rothen, Maria Puschita, Yuriy M. Ambalov, Rolf Henrich, Skaidrius Miliauskas, Anan Wattanathum, Anthony Ramage, Júlio César Abreu de Oliveira, George Kavtaradze, Revaz Tabukashvili, Abdul Manap, Danuta Pupek-Musialik, Anna G. Yevdokimova, Philip Giordano, Joseph De Santo, John Pullman, Pablo Bonvehí, Wolfgang Petermann, Emilio Bouza, Claudia Gavris, Paulo José Zimermann Teixeira, Carlos Ernesto Ferreira Starling, Vsevolod Roudas, James Welker, Maria Cristina Ganaha, Ewa Ziolko, Czeslaw Marcisz, Christian Jakobeit, Juliani Souza Lima, Antonio Tarcisio de Faria Freire, Claudia Gabriela Rodiguez, Eva Francovszky, Andrej Dukat, Christian Grohe, Pawe Piotrowicz, Volodymyr Yefimov, Dwight D. Eisenhower, Clovis Arns da Cunha, Charoen Churchottaworn, Dusica Celeketic, Benoit Misset, Andrzej Rydzewski, Jan Alan Winetz, William Tillis, Zoltán Balikó, Roman Dutka, Mihaela Lupse, H. David Friedland, Evelina Troshanova, Krzysztof Czarnobilski, Maria Auxiliadora Carmo Moreira, Zorica Lazic, Halina Batura-Gabryel, Selcuk Tasci, Márta Bisits, Sulev Meriste, Paul Manos, Gustavo Lopardo, Ana Leticia Gurini, Wolfgang Auch-Schwelk, Gabriela Jimborean, Coenie Koegelenberg, Maciej Hamankiewicz, Roslina Binte, Ian A. Critchley, Thomas M. File, Marija Mitic-Milikic, Yuriy Kolchyn, Thanomsak Anekthananon, Jean Pierre Sollet, Tetiana Tetiana Pertseva, Mari Dzhabalyan, Kai Sukles, Datin Hjh Aziah Ahmad Mahayiddin, Jan Plutinsky, Gyorgy Losonczy, Malgorzata Gutowska-Jablonska, Arvydas Valavicius, Johannes Breedt, Ewa Trebas-Pietras, Alberto Capelastegui, Christian Schrock, Jan Dulawa, Joachim Zerbst, Andreas Fertl, J. Mario Gonzalez, Ishmail Mitha, Donald E. Low, Matthys Basson, Gernot Rohde, Jon Lee, Joachim Lorenz, Istvan Albert, Voicu Mircea Tudorache, Chaicharn Pothirat, Victoria Arama Senior, Marian Wendland, Ricardo Augusto Teijeiro, Conrado Shum, Vasyl Melnyk, Jean-Michel Molina, Abdul Pazak Bin Abdul Muttalif, Olga V. Reshetko, Johannes Roos, Muhammed Fulat, Igor Leschenko, Igor Kaydashev, Mila Petkova, Anna N. Galustyan, Volodymyr Havrysyuk, Jan Kus, Lyudmyla Yashyna, Oleksandr Smolyanyi, George H. Talbot, Vladimir A. Rudnov, Stanislovas Naudziunas, Purvi Mehra, Kiew Kuang Kiat, Victoria Rodionova, Karoly Fonay, Ireneusz Tyszkiewic, Vania Youroukova, Marius Le Roux, Johannes Bonelli, Rosario Menéndez, Maria Patelli, Nikola Milinic, Gheorgita Aron, Krzysztof Janik, Bhaskar Venkateswaralu, Piroon Mootsikapun, Nadiya Monogarova, Ginataras Kramilius, Christian Schumann, Eliza Baranska, and Jaco Jurgens

Subjects
Microbiology (medical), Male, medicine.medical_specialty, Population, law.invention, Randomized controlled trial, Community-acquired pneumonia, Double-Blind Method, law, Internal medicine, Clarithromycin, medicine, Pneumonia, Bacterial, Ceftaroline fosamil, Humans, Pharmacology (medical), Adverse effect, education, Infusions, Intravenous, Antibacterial agent, Aged, Pharmacology, Aged, 80 and over, education.field_of_study, Bacteria, business.industry, Ceftriaxone, Middle Aged, medicine.disease, Surgery, Cephalosporins, Community-Acquired Infections, Infectious Diseases, Treatment Outcome, Female, business, medicine.drug
Abstract

Objectives Ceftaroline, the active form of the prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated with community-acquired pneumonia (CAP), including Streptococcus pneumoniae and common Gram-negative pathogens. FOCUS 1 is a randomized, double-blinded, Phase III study that was conducted to evaluate the efficacy and safety of ceftaroline fosamil in treating patients with CAP. The primary objective was to determine non-inferiority [lower limit of 95% confidence interval (CI) ≥ -10%] in clinical cure rates achieved with ceftaroline fosamil compared with those achieved with ceftriaxone in the clinically evaluable (CE) and modified intent-to-treat efficacy (MITTE) populations. Methods Patients hospitalized in a non-intensive care unit setting with CAP of Pneumonia Outcomes Research Team (PORT) risk class III or IV requiring intravenous (iv) therapy were randomized (1:1) to receive 600 mg of ceftaroline fosamil iv every 12 h or 1 g of ceftriaxone iv every 24 h. Patients also received two 500 mg doses of oral clarithromycin every 12 h administered on day 1. Clinical cure, microbiological response, adverse events (AEs) and laboratory tests were assessed. FOCUS 1 registration number NCT00621504 (http://clinicaltrials.gov/ct2/show/NCT00621504). Results Of 613 enrolled patients, 298 received ceftaroline fosamil and 308 received ceftriaxone. Baseline characteristics between treatment groups were comparable. Clinical cure rates were as follows: CE population, 86.6% (194/224) for ceftaroline fosamil and 78.2% (183/234) for ceftriaxone [difference (95% CI), 8.4% (1.4, 15.4)]; and MITTE population, 83.8% (244/291) for ceftaroline fosamil and 77.7% (233/300) for ceftriaxone [difference (95% CI), 6.2% (-0.2, 12.6)]. Clinical cure rates for CAP caused by S. pneumoniae in the microbiological MITTE population were 88.9% (24/27) and 66.7% (20/30) for ceftaroline fosamil and ceftriaxone, respectively. Both agents were well tolerated, with similar rates of AEs, serious AEs, deaths and discontinuations because of an AE. The most common AEs for ceftaroline fosamil-treated patients were diarrhoea, headache, insomnia and nausea, and the most common AEs for ceftriaxone-treated patients were hypokalaemia, hypertension, nausea and diarrhoea. Conclusions Ceftaroline fosamil demonstrated high clinical cure and microbiological response rates in hospitalized patients with CAP of PORT risk class III or IV. Ceftaroline fosamil was well tolerated, with a safety profile similar to that of ceftriaxone and consistent with the cephalosporin class. In this study, ceftaroline fosamil was an effective and well-tolerated treatment option for CAP.

Published
2011

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