1,278 results on '"Watt, M."'
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2. Asthma outcomes in patients with severe eosinophilic asthma (SEA), with and without comorbid chronic rhinosinusitis with nasal polyps (CRSwNP), treated with benralizumab in the real-world XALOC-1 study
- Author
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Chanez, P., primary, Pelaia, G., additional, Padilla-Galo, A., additional, Loureiro, C., additional, Kwiatek, J., additional, Tran, T.N., additional, Boarino, S., additional, Kayaniyil, S., additional, Nuevo, J., additional, Watt, M., additional, Pardal, M., additional, Shih, V.H., additional, Cohen, D., additional, Shavit, A., additional, Emmanuel, B., additional, Jackson, D.J., additional, and Nair, P., additional
- Published
- 2024
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3. A Prospective Observational Study of Antihemophilic Factor (Recombinant) Prophylaxis Related to Physical Activity Levels in Patients with Hemophilia A in the United States (SPACE)
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Konkle BA, Quon DV, Raffini L, Recht M, Radulescu VC, Carpenter SL, Dunn AL, Lu M, and Watt M
- Subjects
hemophilia a ,recombinant factor viii ,physical activity ,post-authorization study ,prophylaxis ,bleeding ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Barbara A Konkle,1 Doris V Quon,2 Leslie Raffini,3 Michael Recht,4 Vlad C Radulescu,5 Shannon L Carpenter,6 Amy L Dunn,7 Mei Lu,8 Maureen Watt9 1Department of Medicine, The University of Washington and Bloodworks Northwest, Seattle, WA, USA; 2Orthopaedic Hemophilia Treatment Center, Orthopaedic Institute for Children, Los Angeles, CA, USA; 3Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA; 4The Hemophilia Center, Oregon Health & Science University, Portland, OR, USA; 5Department of Pediatric Hematology and Oncology, University of Kentucky Medical Center, Lexington, KY, USA; 6Department of Hematology/Oncology, Children’s Mercy Hospital, Kansas City, MO, USA; 7Hemophilia Treatment Center, Nationwide Children’s Hospital and The Ohio State University College of Medicine, Columbus, OH, USA; 8Takeda Development Center Americas, Inc, Lexington, MA, USA; 9Outcomes Research & Epidemiology, Takeda Pharmaceuticals International AG, Zurich, SwitzerlandCorrespondence: Maureen WattTakeda Pharmaceuticals International AG, Thurgauerstrasse 130, Glattpark-Opfikon, Zurich, 8152, SwitzerlandTel +41 44 555 10 00Fax +41 44 555 10 01Email maureen.watt@takeda.comIntroduction: High collision-risk physical activity can increase bleeding risk in people with hemophilia A, as can increasing the time between factor VIII (FVIII) administration and physical activity. FVIII prophylaxis may be tailored to planned activities to prevent activity-related bleeding.Aim: To explore the relationship between physical activity levels, FVIII infusion timing, and occurrence of bleeding in patients with severe/moderately severe hemophilia A without FVIII inhibitors receiving antihemophilic factor (recombinant) (rAHF; ADVATE®; Baxalta US Inc., a Takeda company, Lexington, MA, USA).Methods: SPACE was a 6-month, prospective, multicenter, observational outcomes study (NCT02190149). Enrolled patients received an eDiary application and a wearable activity tracker, which recorded physical activity, rAHF infusion, and occurrence of bleeding. Physical activity risks were ranked using National Hemophilia Foundation criteria.Results: Fifty-four patients aged 11– 58 years (n = 47 prophylaxis, n = 7 on-demand) were included in the analysis. Patients had a mean (SD) 8.14 (10.94) annualized bleeding rate, and recorded 4980 intervals between an rAHF infusion and physical activity; 1759 (35.3%) of these intervals were ≤ 24 hours. Analysis of recorded eDiary data showed that the risk of activity-related bleeding did not significantly increase with time between last infusion and activity, but did increase with higher-risk physical activities. Analysis of activity tracker recorded data showed that the risk of bleeding reported by patients as spontaneous increased with prolonging time (≤ 24 to > 24 hours) from last infusion to physical activity start (odds ratio 2.65, p < 0.05). Joint health data collected at baseline were not included in the regression analysis because of small sample size; therefore the study could not assess whether patients with more joint disease at baseline were at higher risk of injury-related and reported spontaneous occurrence of bleeding.Conclusion: These results show that activities with a high risk of collision lead to an increased risk of bleeding. Further investigation is warranted to explore potential benefits of FVIII infusion timing to reduce the risks of activity-related occurrence of bleeding.Keywords: hemophilia A, recombinant factor VIII, physical activity, post-authorization study, prophylaxis, bleeding
- Published
- 2021
4. The Physics of the B Factories
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Bevan, A. J., Golob, B., Mannel, Th., Prell, S., Yabsley, B. D., Abe, K., Aihara, H., Anulli, F., Arnaud, N., Aushev, T., Beneke, M., Beringer, J., Bianchi, F., Bigi, I. I., Bona, M., Brambilla, N., rodzicka, J. B, Chang, P., Charles, M. J., Cheng, C. H., Cheng, H. -Y., Chistov, R., Colangelo, P., Coleman, J. P., Drutskoy, A., Druzhinin, V. P., Eidelman, S., Eigen, G., Eisner, A. M., Faccini, R., Flood, K. T ., Gambino, P., Gaz, A., Gradl, W., Hayashii, H., Higuchi, T., Hulsbergen, W. D., Hurth, T., Iijima, T., Itoh, R., Jackson, P. D., Kass, R., Kolomensky, Yu. G., Kou, E., Križan, P., Kronfeld, A., Kumano, S., Kwon, Y. J., Latham, T. E., Leith, D. W. G. S., Lüth, V., Martinez-Vidal, F., Meadows, B. T., Mussa, R., Nakao, M., Nishida, S., Ocariz, J., Olsen, S. L., Pakhlov, P., Pakhlova, G., Palano, A., Pich, A., Playfer, S., Poluektov, A., Porter, F. C., Robertson, S. H., Roney, J. M., Roodman, A., Sakai, Y., Schwanda, C., Schwartz, A. J., Seidl, R., Sekula, S. J., Steinhauser, M., Sumisawa, K., Swanson, E. S., Tackmann, F., Trabelsi, K., Uehara, S., Uno, S., van der Water, R., Vasseur, G., Verkerke, W., Waldi, R., Wang, M. Z., Wilson, F. F., Zupan, J., Zupanc, A., Adachi, I., Albert, J., Banerjee, Sw., Bellis, M., Ben-Haim, E., Biassoni, P., Cahn, R. N., Cartaro, C., Chauveau, J., Chen, C., Chiang, C. C., Cowan, R., Dalseno, J., Davier, M., Davies, C., Dingfelder, J. C., nard, B. Eche, Epifanov, D., Fulsom, B. G., Gabareen, A. M., Gary, J. W., Godang, R., Graham, M. T., Hafner, A., Hamilton, B., Hartmann, T., Hayasaka, K., Hearty, C., Iwasaki, Y., Khodjamirian, A., Kusaka, A., Kuzmin, A., Lafferty, G. D., Lazzaro, A., Li, J., Lindemann, D., Long, O., Lusiani, A., Marchiori, G., Martinelli, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Muller, D. R., Nakazawa, H., Ongmongkolkul, P., Pacetti, S., Palombo, F., Pedlar, T. K., Piilonen, L. E., Pilloni, A., Poireau, V., Prothmann, K., Pulliam, T., Rama, M., Ratcliff, B. N., Roudeau, P., Schrenk, S., Schroeder, T., Schubert, K. R., Shen, C. P., Shwartz, B., Soffer, A., Solodov, E. P., Somov, A., Starič, M., Stracka, S., Telnov, A. V., Todyshev, K. Yu., Tsuboyama, T., Uglov, T., Vinokurova, A., Walsh, J. J., Watanabe, Y., Won, E., Wormser, G., Wright, D. H., Ye, S., Zhang, C. C., Abachi, S., Abashian, A., Abe, N., Abe, R., Abe, T., Abrams, G. S., Adam, I., Adamczyk, K., Adametz, A., Adye, T., Agarwal, A., Ahmed, H., Ahmed, M., Ahmed, S., Ahn, B. S., Ahn, H. S., Aitchison, I. J. R., Akai, K., Akar, S., Akatsu, M., Akemoto, M., Akhmetshin, R., Akre, R., Alam, M. S., Albert, J. N., Aleksan, R., Alexander, J. P., Alimonti, G., Allen, M. T., Allison, J., Allmendinger, T., Alsmiller, J. R. G., Altenburg, D., Alwyn, K. E., An, Q., Anderson, J., Andreassen, R., Andreotti, D., Andreotti, M., Andress, J. C., Angelini, C., Anipko, D., Anjomshoaa, A., Anthony, P. L., Antillon, E. A., Antonioli, E., Aoki, K., Arguin, J. F., Arinstein, K., Arisaka, K., Asai, K., Asai, M., Asano, Y., Asgeirsson, D. J., Asner, D. M., Aso, T., Aspinwall, M. L., Aston, D., Atmacan, H., Aubert, B., Aulchenko, V., Ayad, R., Azemoon, T., Aziz, T., Azzolini, V., Azzopardi, D. E., Baak, M. A., Back, J. J., Bagnasco, S., Bahinipati, S., Bailey, D. S., Bailey, S., Bailly, P., van Bakel, N., Bakich, A. M., Bala, A., Balagura, V., Baldini-Ferroli, R., Ban, Y., Banas, E., Band, H. R., Banerjee, S., Baracchini, E., Barate, R., Barberio, E., Barbero, M., Bard, D. J., Barillari, T., Barlow, N. R., Barlow, R. J., Barrett, M., Bartel, W., Bartelt, J., Bartoldus, R., Batignani, G., Battaglia, M., Bauer, J. M., Bay, A., Beaulieu, M., Bechtle, P., Beck, T. W., Becker, J., Becla, J., Bedny, I., Behari, S., Behera, P. K., Behn, E., Behr, L., Beigbeder, C., Beiline, D., Bell, R., Bellini, F., Bellodi, G., Belous, K., Benayoun, M., Benelli, G., Benitez, J. F., Benkebil, M., Berger, N., Bernabeu, J., Bernard, D., Bernet, R., Bernlochner, F. U., Berryhill, J. W., Bertsche, K., Besson, P., Best, D. S., Bettarini, S., Bettoni, D., Bhardwaj, V., Bhimji, W., Bhuyan, B., Biagini, M. E., Biasini, M., van Bibber, K., Biesiada, J., Bingham, I., Bionta, R. M., Bischofberger, M., Bitenc, U., Bizjak, I., Blanc, F., Blaylock, G., Blinov, V. E., Bloom, E., Bloom, P. C., Blount, N. L., Blouw, J., Bly, M., Blyth, S., Boeheim, C. T., Bomben, M., Bondar, A., Bondioli, M., Bonneaud, G. R., Bonvicini, G., Booke, M., Booth, J., Borean, C., Borgland, A. W., Borsato, E., Bosi, F., Bosisio, L., Botov, A. A., Bougher, J., Bouldin, K., Bourgeois, P., Boutigny, D., Bowerman, D. A., Boyarski, A. M., Boyce, R. F., Boyd, J. T., Bozek, A., Bozzi, C., Bračko, M., Brandenburg, G., Brandt, T., Brau, B., Brau, J., Breon, A. B., Breton, D., Brew, C., Briand, H., Bright-Thomas, P. G., Brigljević, V., Britton, D. I., Brochard, F., Broomer, B., Brose, J., Browder, T. E., Brown, C. L., Brown, C. M., Brown, D. N., Browne, M., Bruinsma, M., Brunet, S., Bucci, F., Buchanan, C., Buchmueller, O. L., Bünger, C., Bugg, W., Bukin, A. D., Bula, R., Bulten, H., Burchat, P. R., Burgess, W., Burke, J. P., Button-Shafer, J., Buzykaev, A. R., Buzzo, A., Cai, Y., Calabrese, R., Calcaterra, A., Calderini, G., Camanzi, B., Campagna, E., Campagnari, C., Capra, R., Carassiti, V., Carpinelli, M., Carroll, M., Casarosa, G., Casey, B. C. K., Cason, N. M., Castelli, G., Cavallo, N., Cavoto, G., Cecchi, A., Cenci, R., Cerizza, G., Cervelli, A., Ceseracciu, A., Chai, X., Chaisanguanthum, K. S., Chang, M. C., Chang, Y. H., Chang, Y. W., Chao, D. S., Chao, M., Chao, Y., Charles, E., Chavez, C. A., Cheaib, R., Chekelian, V., Chen, A., Chen, E., Chen, G. P., Chen, H. F., Chen, J. -H., Chen, J. C., Chen, K. F., Chen, P., Chen, S., Chen, W. T., Chen, X., Chen, X. R., Chen, Y. Q., Cheng, B., Cheon, B. G., Chevalier, N., Chia, Y. M., Chidzik, S., Chilikin, K., Chistiakova, M. V., Cizeron, R., Cho, I. S., Cho, K., Chobanova, V., Choi, H. H. F., Choi, K. S., Choi, S. K., Choi, Y., Choi, Y. K., Christ, S., Chu, P. H., Chun, S., Chuvikov, A., Cibinetto, G., Cinabro, D., Clark, A. R., Clark, P. J., Clarke, C. K., Claus, R., Claxton, B., Clifton, Z. C., Cochran, J., Cohen-Tanugi, J., Cohn, H., Colberg, T., Cole, S., Colecchia, F., Condurache, C., Contri, R., Convert, P., Convery, M. R., Cooke, P., Copty, N., Cormack, C. M., Corso, F. Dal, Corwin, L. A., Cossutti, F., Cote, D., Ramusino, A. Cotta, Cottingham, W. N., Couderc, F., Coupal, D. P., Covarelli, R., Cowan, G., Craddock, W. W., Crane, G., Crawley, H. B., Cremaldi, L., Crescente, A., Cristinziani, M., Crnkovic, J., Crosetti, G., Cuhadar-Donszelmann, T., Cunha, A., Curry, S., D'Orazio, A., Dû, S., Dahlinger, G., Dahmes, B., Dallapiccola, C., Danielson, N., Danilov, M., Das, A., Dash, M., Dasu, S., Datta, M., Daudo, F., Dauncey, P. D., David, P., Davis, C. L., Day, C. T., De Mori, F., De Domenico, G., De Groot, N., De la Vaissière, C., de la Vaissière, Ch., de Lesquen, A., De Nardo, G., de Sangro, R., De Silva, A., DeBarger, S., Decker, F. J., Sanchez, P. del Amo, Del Buono, L., Del Gamba, V., del Re, D., Della Ricca, G., Denig, A. G., Derkach, D., Derrington, I. M., DeStaebler, H., Destree, J., Devmal, S., Dey, B., Di Girolamo, B., Di Marco, E., Dickopp, M., Dima, M. O., Dittrich, S., Dittongo, S., Dixon, P., Dneprovsky, L., Dohou, F., Doi, Y., Doležal, Z., Doll, D. A., Donald, M., Dong, L., Dong, L. Y., Dorfan, J., Dorigo, A., Dorsten, M. P., Dowd, R., Dowdell, J., Drásal, Z., Dragic, J., Drummond, B. W., Dubitzky, R. S., Dubois-Felsmann, G. P., Dubrovin, M. S., Duh, Y. C., Duh, Y. T., Dujmic, D., Dungel, W., Dunwoodie, W., Dutta, D., Dvoretskii, A., Dyce, N., Ebert, M., Eckhart, E. A., Ecklund, S., Eckmann, R., Eckstein, P., Edgar, C. L., Edwards, A. J., Egede, U., Eichenbaum, A. M., Elmer, P., Emery, S., Enari, Y., Enomoto, R., Erdos, E., Erickson, R., Ernst, J. A., Erwin, R. J., Escalier, M., Eschenburg, V., Eschrich, I., Esen, S., Esteve, L., Evangelisti, F., Everton, C. W., Eyges, V., Fabby, C., Fabozzi, F., Fahey, S., Falbo, M., Fan, S., Fang, F., Fanin, C., Farbin, A., Farhat, H., Fast, J. E., Feindt, M., Fella, A., Feltresi, E., Ferber, T., Fernholz, R. E., Ferrag, S., Ferrarotto, F., Ferroni, F., Field, R. C., Filippi, A., Finocchiaro, G., Fioravanti, E., da Costa, J. Firmino, Fischer, P. -A., Fisher, A., Fisher, P. H., Flacco, C. J., Flack, R. L., Flaecher, H. U., Flanagan, J., Flanigan, J. M., Ford, K. E., Ford, W. T., Forster, I. J., Forti, A. C., Forti, F., Fortin, D., Foster, B., Foulkes, S. D., Fouque, G., Fox, J., Franchini, P., Sevilla, M. Franco, Franek, B., Frank, E. D., Fransham, K. B., Fratina, S., Fratini, K., Frey, A., Frey, R., Friedl, M., Fritsch, M., Fry, J. R., Fujii, H., Fujikawa, M., Fujita, Y., Fujiyama, Y., Fukunaga, C., Fukushima, M., Fullwood, J., Funahashi, Y., Funakoshi, Y., Furano, F., Furman, M., Furukawa, K., Futterschneider, H., Gabathuler, E., Gabriel, T. A., Gabyshev, N., Gaede, F., Gagliardi, N., Gaidot, A., Gaillard, J. -M., Gaillard, J. R., Galagedera, S., Galeazzi, F., Gallo, F., Gamba, D., Gamet, R., Gan, K. K., Gandini, P., Ganguly, S., Ganzhur, S. F., Gao, Y. Y., Gaponenko, I., Garmash, A., Tico, J. Garra, Garzia, I., Gaspero, M., Gastaldi, F., Gatto, C., Gaur, V., Geddes, N. I., Geld, T. L., Genat, J. -F., George, K. A., George, M., George, S., Georgette, Z., Gershon, T. J., Gill, M. S., Gillard, R., Gilman, J. D., Giordano, F., Giorgi, M. A., Giraud, P. -F., Gladney, L., Glanzman, T., Glattauer, R., Go, A., Goetzen, K., Goh, Y. M., Gokhroo, G., Goldenzweig, P., Golubev, V. B., Gopal, G. P., Gordon, A., Gorišek, A., Goriletsky, V. I., Gorodeisky, R., Gosset, L., Gotow, K., Gowdy, S. J., Graffin, P., Grancagnolo, S., Grauges, E., Graziani, G., Green, M. G., Greene, M. G., Grenier, G. J., Grenier, P., Griessinger, K., Grillo, A. A., Grinyov, B. V., Gritsan, A. V., Grosdidier, G., Perdekamp, M. Grosse, Grosso, P., Grothe, M., Groysman, Y., Grünberg, O., Guido, E., Guler, H., Gunawardane, N. J. W., Guo, Q. H., Guo, R. S., Guo, Z. J., Guttman, N., Ha, H., Ha, H. C., Haas, T., Haba, J., Hachtel, J., Hadavand, H. K., Hadig, T., Hagner, C., Haire, M., Haitani, F., Haji, T., Haller, G., Halyo, V., Hamano, K., Hamasaki, H., de Monchenault, G. Hamel, Hamilton, J., Hamilton, R., Hamon, O., Han, B. Y., Han, Y. L., Hanada, H., Hanagaki, K., Handa, F., Hanson, J. E., Hanushevsky, A., Hara, K., Hara, T., Harada, Y., Harrison, P. F., Harrison, T. J., Harrop, B., Hart, A. J., Hart, P. A., Hartfiel, B. L., Harton, J. L., Haruyama, T., Hasan, A., Hasegawa, Y., Hast, C., Hastings, N. C., Hasuko, K., Hauke, A., Hawkes, C. M., Hayashi, K., Hazumi, M., Hee, C., Heenan, E. M., Heffernan, D., Held, T., Henderson, R., Henderson, S. W., Hertzbach, S. S., Hervé, S., Heß, M., Heusch, C. A., Hicheur, A., Higashi, Y., Higasino, Y., Higuchi, I., Hikita, S., Hill, E. J., Himel, T., Hinz, L., Hirai, T., Hirano, H., Hirschauer, J. F., Hitlin, D. G., Hitomi, N., Hodgkinson, M. C., Höcker, A., Hoi, C. T., Hojo, T., Hokuue, T., Hollar, J. J., Hong, T. M., Honscheid, K., Hooberman, B., Hopkins, D. A., Horii, Y., Hoshi, Y., Hoshina, K., Hou, S., Hou, W. S., Hryn'ova, T., Hsiung, Y. B., Hsu, C. L., Hsu, S. C., Hu, H., Hu, T., Huang, H. C., Huang, T. J., Huang, Y. C., Huard, Z., Huffer, M. E., Hufnagel, D., Hung, T., Hutchcroft, D. E., Hyun, H. J., Ichizawa, S., Igaki, T., Igarashi, A., Igarashi, S., Igarashi, Y., Igonkina, O., Ikado, K., Ikeda, H., Ikeda, K., Ilic, J., Inami, K., Innes, W. R., Inoue, Y., Ishikawa, A., Ishino, H., Itagaki, K., Itami, S., Itoh, K., Ivanchenko, V. N., Iverson, R., Iwabuchi, M., Iwai, G., Iwai, M., Iwaida, S., Iwamoto, M., Iwasaki, H., Iwasaki, M., Iwashita, T., Izen, J. M., Jackson, D. J., Jackson, F., Jackson, G., Jackson, P. S., Jacobsen, R. G., Jacoby, C., Jaegle, I., Jain, V., Jalocha, P., Jang, H. K., Jasper, H., Jawahery, A., Jayatilleke, S., Jen, C. M., Jensen, F., Jessop, C. P., Ji, X. B., John, M. J. J., Johnson, D. R., Johnson, J. R., Jolly, S., Jones, M., Joo, K. K., Joshi, N., Joshi, N. J., Judd, D., Julius, T., Kadel, R. W., Kadyk, J. A., Kagan, H., Kagan, R., Kah, D. H., Kaiser, S., Kaji, H., Kajiwara, S., Kakuno, H., Kameshima, T., Kaminski, J., Kamitani, T., Kaneko, J., Kang, J. H., Kang, J. S., Kani, T., Kapusta, P., Karbach, T. M., Karolak, M., Karyotakis, Y., Kasami, K., Katano, G., Kataoka, S. U., Katayama, N., Kato, E., Kato, Y., Kawai, H., Kawai, M., Kawamura, N., Kawasaki, T., Kay, J., Kay, M., Kelly, M. P., Kelsey, M. H., Kent, N., Kerth, L. T., Khan, A., Khan, H. R., Kharakh, D., Kibayashi, A., Kichimi, H., Kiesling, C., Kikuchi, M., Kikutani, E., Kim, B. H., Kim, C. H., Kim, D. W., Kim, H., Kim, H. J., Kim, H. O., Kim, H. W., Kim, J. B., Kim, J. H., Kim, K. T., Kim, M. J., Kim, P., Kim, S. K., Kim, S. M., Kim, T. H., Kim, Y. I., Kim, Y. J., King, G. J., Kinoshita, K., Kirk, A., Kirkby, D., Kitayama, I., Klemetti, M., Klose, V., Klucar, J., Knecht, N. S., Knoepfel, K. J., Knowles, D. J., Ko, B. R., Kobayashi, N., Kobayashi, S., Kobayashi, T., Kobel, M. J., Koblitz, S., Koch, H., Kocian, M. L., Kodyš, P., Koeneke, K., Kofler, R., Koike, S., Koishi, S., Koiso, H., Kolb, J. A., Kolya, S. D., Kondo, Y., Konishi, H., Koppenburg, P., Koptchev, V. B., Kordich, T. M. B., Korol, A. A., Korotushenko, K., Korpar, S., Kouzes, R. T., Kovalskyi, D., Kowalewski, R., Kozakai, Y., Kozanecki, W., Kral, J. F., Krasnykh, A., Krause, R., Kravchenko, E. 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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C. Please note that version 3 on the archive is the auxiliary version of the Physics of the B Factories book. This uses the notation alpha, beta, gamma for the angles of the Unitarity Triangle. The nominal version uses the notation phi_1, phi_2 and phi_3. Please cite this work as Eur. Phys. J. C74 (2014) 3026., Comment: 928 pages, version 3 (arXiv:1406.6311v3) corresponds to the alpha, beta, gamma version of the book, the other versions use the phi1, phi2, phi3 notation
- Published
- 2014
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5. An in vitro screening system to assess aluminum toxicity in sugarcane (Saccharum spp.) cultivars
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Snyman, S. J., Naidoo, M., Watt, M. P., and Rutherford, R. S.
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- 2019
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6. Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
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Watt, K. I., Henstridge, D. C., Ziemann, M., Sim, C. B., Montgomery, M. K., Samocha-Bonet, D., Parker, B. L., Dodd, G. T., Bond, S. T., Salmi, T. M., Lee, R. S., Thomson, R. E., Hagg, A., Davey, J. R., Qian, H., Koopman, R., El-Osta, A., Greenfield, J. R., Watt, M. J., Febbraio, M. A., Drew, B. G., Cox, A. G., Porrello, E. R., Harvey, K. F., and Gregorevic, P.
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- 2021
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7. Comparative analysis of microRNA expression in mouse and human brown adipose tissue
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Kajimura, Shingo, Güller, I, McNaughton, S, Crowley, T, Gilsanz, V, Watt, M, and Russell, AP
- Abstract
© 2015 Güller et al.Background: In small mammals brown adipose tissue (BAT) plays a predominant role in regulating energy expenditure (EE) via adaptive thermogenesis. New-born babies require BAT to control their body temperature, however its relevance in a
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- 2015
8. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
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- Published
- 2019
- Full Text
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9. BURDEN OF HEREDITARY ANGIOEDEMA: FINDINGS FROM A MULTINATIONAL SURVEY OF CAREGIVERS FOR ADULT PATIENTS
- Author
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Martinez-Saguer, I., primary, Grumach, A., additional, Zwiener, R., additional, Simon, A., additional, Murphy, R., additional, Cruz, M. De La, additional, and Watt, M., additional
- Published
- 2023
- Full Text
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10. BURDEN OF ILLNESS IN ADULT PATIENTS WITH HEREDITARY ANGIOEDEMA: Results: FROM A MULTINATIONAL SURVEY
- Author
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Martinez-Saguer, I., primary, Grumach, A., additional, Zwiener, R., additional, Simon, A., additional, Murphy, R., additional, Cruz, M. De La, additional, and Watt, M., additional
- Published
- 2023
- Full Text
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11. BURDEN ON CAREGIVERS TO PEDIATRIC PATIENTS WITH HEREDITARY ANGIOEDEMA: Results: FROM A MULTINATIONAL SURVEY
- Author
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Martinez-Saguer, I., primary, Grumach, A., additional, Zwiener, R., additional, Simon, A., additional, Murphy, R., additional, Cruz, M. De La, additional, and Watt, M., additional
- Published
- 2023
- Full Text
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12. POLAR Investigation of the Sun - POLARIS
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Appourchaux, T., Liewer, P., Watt, M., Alexander, D., Andretta, V., Auchere, F., D'Arrigo, P., Ayon, J., Corbard, T., Fineschi, S., Finsterle, W., Floyd, L., Garbe, G., Gizon, L., Hassler, D., Harra, L., Kosovichev, A., Leibacher, J., Leipold, M., Murphy, N., Maksimovic, M., Martinez-Pillet, V., Matthews, B. S. A., Mewaldt, R., Moses, D., Newmark, J., Regnier, S., Schmutz, W., Socker, D., Spadaro, D., Stuttard, M., Trosseille, C., Ulrich, R., Velli, M., Vourlidas, A., Wimmer-Schweingruber, C. R., and Zurbuchen, T.
- Subjects
Astrophysics - Abstract
The POLAR Investigation of the Sun (POLARIS) mission uses a combination of a gravity assist and solar sail propulsion to place a spacecraft in a 0.48 AU circular orbit around the Sun with an inclination of 75 degrees with respect to solar equator. This challenging orbit is made possible by the challenging development of solar sail propulsion. This first extended view of the high-latitude regions of the Sun will enable crucial observations not possible from the ecliptic viewpoint or from Solar Orbiter. While Solar Orbiter would give the first glimpse of the high latitude magnetic field and flows to probe the solar dynamo, it does not have sufficient viewing of the polar regions to achieve POLARIS' primary objective : determining the relation between the magnetism and dynamics of the Sun's polar regions and the solar cycle., Comment: 23 pages, 14 figures, 4 tables, Accepted by Experimental Astronomy
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- 2008
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13. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den 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Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Román, Luis San, Menon, Bijoy K, Blasco, Jordi, Hernández-Pérez, María, Dávalos, Antoni, Majoie, Charles B L M, Campbell, Bruce C V, Guillemin, Francis, Lingsma, Hester, Epstein, Jonathan, Marquering, Henk, Wong, John H, Lopes, Demetrius, Reimann, Gernot, Dippel, Diederik W J, Coutts, Shelagh, du Mesnil de Rochemont, Richard, Yavagal, Dileep, Ferre, Jean Christophe, Roos, Yvo B W E M, Liebeskind, David S, Lenthall, Robert, Molina, Carlos, Al Ajlan, Fahad S, Reddy, Vivek, Dowlatshahi, Dar, Sourour, Nader-Antoine, Oppenheim, Catherine, Mitha, Alim P, Weimar, Christian, van Oostenbrugge, Robert J, Cobo, Erik, Demchuk, Andrew M, Boers, Anna M M, Ford, Gary A, Brown, B Scott, Jovin, Tudor, van Zwam, Wim H, Hill, Michael D, White, Phil, and Bracard, Serge
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14. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, 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Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil 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Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Brown, Martin M, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, van Zwam, Wim H, Menon, Bijoy K, Dippel, Diederik W J, Demchuk, Andrew M, Bracard, Serge, Dávalos, Antoni, Majoie, Charles B L M, Ford, Gary A, de la Ossa, Natalia Pérez, Kelly, Michael, Bourcier, Romain, Roos, Yvo B W E M, Bang, Oh Young, Nogueira, Raul G, Devlin, Thomas G, Clarençon, Frédéric, Burns, Paul, Carpenter, Jeffrey, Yavagal, Dileep R, Pereira, Vitor Mendes, Quesada, Helena, Epstein, Jonathan, Rubiera, Marta, Urra, Xabier, Micard, Emilien, Brown, Scott, Guillemin, Francis, van Oostenbrugge, Robert J, Jovin, Tudor G, and Hill, Michael D
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- 2018
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15. Methylglyoxal-induced enhancement of somatic embryogenesis and associated metabolic changes in sugarcane (Saccharum spp. hybrids)
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Mahlanza, Tendekai, Rutherford, R. Stuart, Snyman, Sandy J., and Watt, M. Paula
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- 2019
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16. 'De-escalation' strategy using micafungin for the treatment of systemic Candida infections: budget impact in France and Germany
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van Engen A, Casamayor M, Kim S, Watt M, and Odeyemi I
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Candida ,De-escalation ,Fluconazole ,Micafungin ,Medicine (General) ,R5-920 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Anke van Engen,1 Montserrat Casamayor,2 Soyoung Kim,3 Maureen Watt,4 Isaac Odeyemi4 1Quintiles Consulting, Hoofddorp, the Netherlands; 2Quintiles Consulting, Barcelona, Spain; 3Astellas Pharma Singapore Pte., Singapore; 4Astellas Pharma Inc., Chertsey, UK Background: The incidence of azole-resistant Candida infections is increasing. Consequently, guidelines for treating systemic Candida infection (SCI) recommend a “de-escalation” strategy: initial broad-spectrum antifungal agents (e.g., echinocandins), followed by switching to fluconazole if isolates are fluconazole sensitive, rather than “escalation” with initial fluconazole treatment and then switching to echinocandins if isolates are fluconazole resistant. However, fluconazole may continue to be used as first-line treatment in view of its low acquisition costs. The aim of this study was, therefore, to evaluate the budget impact of the de-escalation strategy using micafungin compared with the escalation strategy in France and Germany.Methods: A budget impact model was used to compare de-escalation to escalation strategies. As well as survival, clinical success (resolution/reduction of symptoms and radiographic abnormalities associated with fungal infection), was considered, as was mycological success (eradication of Candida from the bloodstream). Health economic outcomes included cost per health state according to clinical success and mycological success, and budget impact. A 42-day time horizon was used.Results: For all patients with SCI, the budget impact of using de-escalation rather than escalation was greater, but improved rates of survival, clinical success and mycological success were apparent with de-escalation. In patients with fluconazole-resistant isolates, clinical success rates and survival were improved by ~72% with de-escalation versus escalation, producing cost savings of €6,374 and €356 per patient in France and Germany, respectively; improvements of ~72% in mycological success rates with de-escalation versus escalation did not translate into cost savings. Conclusion: Modeling provides evidence that when treating SCI in individuals at risk of azole-resistant infections, de-escalation from micafungin has potential cost savings associated with improved clinical success rates. Keywords: Candida, de-escalation, fluconazole, micafungin
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- 2017
17. EE122 The Economic Impact of a Psychosocial Utility Benefit Associated with Pre-Exposure Prophylaxis (PrEP) for COVID-19, in Immunocompromised (IC) Individuals – a Case Study for Future PrEP Evaluations
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Henry, T., primary, Fisher, M., additional, Holland, T., additional, Watt, M., additional, Arnetorp, S., additional, Jańska, A., additional, and Squirrell, D., additional
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- 2023
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18. A personalized, multi-platform nutrition, exercise, and lifestyle coaching program: A pilot in women
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Héroux, M., Watt, M., McGuire, K.A., and Berardi, J.M.
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- 2017
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19. Agronomic evaluation and molecular characterisation of the acetolactate synthase gene in imazapyr tolerant sugarcane (Saccharum hybrid) genotypes
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Koetle, Motselisi J., Lloyd Evans, Dyfed, Singh, Varnika, Snyman, Sandy J., Rutherford, R. Stuart, and Watt, M. Paula
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- 2018
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20. (872) Preclinical Evaluation of the VP.S ENCORE™ Cardiac Preservation Device
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Veraza, R., primary, Andrijauskaite, K., additional, Lopez, R., additional, Cano, I., additional, Cisneros, E., additional, Jessop, I., additional, Watt, M., additional, Morales Garza, M., additional, Elgalad, A., additional, and Bunegin, L., additional
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- 2023
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21. Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy — A focus on energy expenditure
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Stefanidis, A, Lee, C M C, Greaves, E, Montgomery, M K, Arnold, M, Newn, S, Budin, A J, Lemus, M B, Foldi, C J, Burton, P R, Brown, W A, Lutz, T A, Watt, M J, Oldfield, B J, Stefanidis, A, Lee, C M C, Greaves, E, Montgomery, M K, Arnold, M, Newn, S, Budin, A J, Lemus, M B, Foldi, C J, Burton, P R, Brown, W A, Lutz, T A, Watt, M J, and Oldfield, B J
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Objective: Bariatric surgery remains the only effective and durable treatment option for morbid obesity. Vertical Sleeve Gastrectomy (VSG) is currently the most widely performed of these surgeries primarily because of its proven efficacy in generating rapid onset weight loss, improved glucose regulation and reduced mortality compared with other invasive procedures. VSG is associated with reduced appetite, however, the relative importance of energy expenditure to VSG-induced weight loss and changes in glucose regulation, particularly that in brown adipose tissue (BAT), remains unclear. The aim of this study was to investigate the role of BAT thermogenesis in the efficacy of VSG in a rodent model. Methods: Diet-induced obese male Sprague-Dawley rats were either sham-operated, underwent VSG surgery or were pair-fed to the food consumed by the VSG group. Rats were also implanted with biotelemetry devices between the interscapular lobes of BAT to assess local changes in BAT temperature as a surrogate measure of thermogenic activity. Metabolic parameters including food intake, body weight and changes in body composition were assessed. To further elucidate the contribution of energy expenditure via BAT thermogenesis to VSG-induced weight loss, a separate cohort of chow-fed rats underwent complete excision of the interscapular BAT (iBAT lipectomy) or chemical denervation using 6-hydroxydopamine (6-OHDA). To localize glucose uptake in specific tissues, an oral glucose tolerance test was combined with an intraperitoneal injection of 14C-2-deoxy-d-glucose (14C-2DG). Transneuronal viral tracing was used to identify 1) sensory neurons directed to the stomach or small intestine (H129-RFP) or 2) chains of polysynaptically linked neurons directed to BAT (PRV-GFP) in the same animals. Results: Following VSG, there was a rapid reduction in body weight that was associated with reduced food intake, elevated BAT temperature and improved glucose regulation. Rats that underwent VSG had el
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- 2023
22. Effect of two watering regimes on the biomass and leaf Ca and Fe content of four cloned genotypes of Solanum nigrum Linn. at different physiological ages
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Shaik, Shakira, primary, Sigamoney, Megan, additional, and Watt, M. Paula, additional
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- 2022
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23. SUSTAINED IMPROVEMENT IN HEALTH-RELATED QUALITY OF LIFE WITH CONTINUED LANADELUMAB TREATMENT IN HEREDITARY ANGIOEDEMA
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Watt, M., primary, Devercelli, G., additional, Lumry, W., additional, Maurer, M., additional, Weller, K., additional, Riedl, M., additional, Meunier, J., additional, and Banerji, A., additional
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- 2022
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24. Improving Cancer Care in the HIV Population: Qualitative Research to Identify Provider Knowledge, Attitudes and Practices
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Henry, V.T., primary, Galyean, P., additional, Young, J., additional, Zickmund, S., additional, Cherenack, E., additional, Knettel, B., additional, Bartlett, J., additional, Pollak, K.I., additional, Ubel, P., additional, Watt, M., additional, Fagerlin, A.S., additional, and Suneja, G., additional
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- 2022
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25. MATCHING-ADJUSTED INDIRECT TREATMENT COMPARISON BETWEEN LANADELUMAB AND BEROTRALSTAT FOR HEREDITARY ANGIOEDEMA PROPHYLAXIS
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Watt, M., primary, Malmenäs, M., additional, Romanus, D., additional, and Haeussler, K., additional
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- 2022
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26. P207 The influence of obesity on the clinical outcome of benralizumab treatment in severe eosinophilic asthma a subgroup analysis from the BPAP study
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Nanzer, A, primary, Burhan, H, additional, Menzies-Gow, A, additional, Rupani, H, additional, Pfeffer, P, additional, Clifton, I, additional, Faruqi, S, additional, Dhariwal, J, additional, Morris, T, additional, Lipworth, J, additional, Watt, M, additional, and Jackson, DJ, additional
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- 2022
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27. LONG-TERM EFFICACY, SAFETY, AND QUALITY OF LIFE WITH LANADELUMAB TREATMENT IN ADOLESCENTS WITH HEREDITARY ANGIOEDEMA
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Craig, T., primary, Tachdjian, R., additional, Bernstein, J., additional, Anderson, J., additional, Nurse, C., additional, Watt, M., additional, Juethner, S., additional, and Yu, M., additional
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- 2022
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28. P11 Characteristics and long-term real-world outcomes of severe asthma patients treated with benralizumab in the United Kingdom; the BPAP study
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Jackson, DJ, primary, Burhan, H, additional, Menzies-Gow, A, additional, Rupani, H, additional, Pfeffer, PE, additional, Clifton, IJ, additional, Faruqi, S, additional, Nanzer, AM, additional, Dhariwal, J, additional, Morris, T, additional, Lipworth, J, additional, and Watt, M, additional
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- 2022
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29. Asthma exacerbation rate reduction with benralizumab in an integrated analysis of the real-world XALOC-1 study
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Jackson, D J, primary, Pelaia, G, additional, Padilla-Galo, A, additional, Watt, M, additional, Kayaniyil, S, additional, Boarino, S, additional, Tena, J S, additional, Shih, V H, additional, Tran, T N, additional, Arbetter, D, additional, Cohen, D, additional, Katial, R, additional, Kwiatek, J, additional, Shavit, A, additional, Emmanuel, B, additional, and Nair, P, additional
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- 2022
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30. REAL-WORLD PATTERNS OF LANADELUMAB DOWN-TITRATION IN PATIENTS WITH HEREDITARY ANGIOEDEMA
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Watt, M., Chang, R., Yu, L., Clear, L., and DerSarkissian, M.
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- 2024
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31. Visualizing the Radiation Experience for Rural Cancer Patients
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Seifert, S.B., Stephens, M.J., Ariotti, A., King, A., Watt, M., and Suneja, G.
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- 2024
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32. Genetically vigorous wheat genotypes maintain superior early growth in no-till soils
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Rebetzke, G. J., Kirkegaard, J. A, Watt, M., and Richards, R. A.
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- 2014
33. Soil coring at multiple field environments can directly quantify variation in deep root traits to select wheat genotypes for breeding
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Wasson, A. P., Rebetzke, G. J., Kirkegaard, J. A., Christopher, J., Richards, R. A., and Watt, M.
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- 2014
34. The History of al-Ṭabarī Vol. 6: Muhammad at Mecca
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W. Montgomery Watt, M. V. McDonald
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- 2015
35. Safety and savings from penicillin allergy de-labelling in pregnancy: good stewardship, good cents
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Atkinson A, Zhang BY, Mak R, Paquette V, Dionne F, Watt M, Erdle S, Van schalkwyk J, Wong T, Poliquin V, and Elwood C
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Obstetrics and Gynecology - Published
- 2023
36. Rapid Screening of Sugarcane Plantlets for In Vitro Mannitol-Induced Stress
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Snyman, S. J., Mhlanga, P., and Watt, M. P.
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- 2016
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37. Micropropagation of Eucalyptus
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Watt, M. P., Blakeway, F. C., Mokotedi, M. E. O., Jain, S. M., Jain, S. Mohan, editor, and Ishii, Katsuaki, editor
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- 2003
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38. A rapid, controlled-environment seedling root screen for wheat correlates well with rooting depths at vegetative, but not reproductive, stages at two field sites
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Watt, M., Moosavi, S., Cunningham, S. C., Kirkegaard, J. A., Rebetzke, G. J., and Richards, R. A.
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- 2013
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39. Response of millet and sorghum to a varying water supply around the primary and nodal roots
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Rostamza, M., Richards, R. A., and Watt, M.
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- 2013
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40. Rhizosphere models: their concepts and application to plant-soil ecosystems
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Kuppe, CW, Schnepf, A, von Lieres, E, Watt, M, Postma, JA, Kuppe, CW, Schnepf, A, von Lieres, E, Watt, M, and Postma, JA
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Background The rhizosphere is the influence-sphere of the root. It is a local ecosystem with complex functions that determine nutrient uptake, cycling of resources, and plant health. Mathematical models can quantitatively explain and help to understand rhizosphere complexity. To interpret model predictions and relevance of processes, we require understanding of the underlying concepts. Conceptualization of rhizosphere processes bridges mathematical modeling and experimental work and thus is key to understanding the rhizosphere. Scope We review concepts and assumptions foundational to the modeling of soil-plant-microorganism processes in the rhizosphere. Rhizosphere models are designed to simulate a plurality of components (solutes, substrates, and microorganisms). They specify components and interactions, drawing from the disciplines of soil science, botany, microbiology, and ecology. Solute transport models are applied to describe bioavailability in the rhizosphere. The root is typically a sink (e.g. nutrient uptake) or source (e.g. exudation) for one or more solutes. Microorganisms are usually described in time only, neglecting possible spatial movement. Interactions between components, e.g. chemical reactions and substrate-dependent bacterial growth rates, are usually described by coupling via reaction terms. Conclusions Rhizosphere models share concepts that we organized in a collective framework. This collective framework facilitates the development of new models. The interdisciplinary approach in which knowledge from soil ecology, botany, and soil physics are combined in rhizosphere models has proven fruitful for applications in plant and soil systems. We advocate multi-component-multi-interaction ecosystems around the root, with each component represented by an advection-diffusion-motility-reaction equation.
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- 2022
41. A toolkit to rapidly modify root systems through single plant selection
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Rambla, C, Van der Meer, S, Voss-Fels, KP, Makhoul, M, Obermeier, C, Rod, S, Ober, ES, Watt, M, Alahmad, S, Hickey, LT, Rambla, C, Van der Meer, S, Voss-Fels, KP, Makhoul, M, Obermeier, C, Rod, S, Ober, ES, Watt, M, Alahmad, S, and Hickey, LT
- Abstract
BACKGROUND: The incorporation of root traits into elite germplasm is typically a slow process. Thus, innovative approaches are required to accelerate research and pre-breeding programs targeting root traits to improve yield stability in different environments and soil types. Marker-assisted selection (MAS) can help to speed up the process by selecting key genes or quantitative trait loci (QTL) associated with root traits. However, this approach is limited due to the complex genetic control of root traits and the limited number of well-characterised large effect QTL. Coupling MAS with phenotyping could increase the reliability of selection. Here we present a useful framework to rapidly modify root traits in elite germplasm. In this wheat exemplar, a single plant selection (SPS) approach combined three main elements: phenotypic selection (in this case for seminal root angle); MAS using KASP markers (targeting a root biomass QTL); and speed breeding to accelerate each cycle. RESULTS: To develop a SPS approach that integrates non-destructive screening for seminal root angle and root biomass, two initial experiments were conducted. Firstly, we demonstrated that transplanting wheat seedlings from clear pots (for seminal root angle assessment) into sand pots (for root biomass assessment) did not impact the ability to differentiate genotypes with high and low root biomass. Secondly, we demonstrated that visual scores for root biomass were correlated with root dry weight (r = 0.72), indicating that single plants could be evaluated for root biomass in a non-destructive manner. To highlight the potential of the approach, we applied SPS in a backcrossing program which integrated MAS and speed breeding for the purpose of rapidly modifying the root system of elite bread wheat line Borlaug100. Bi-directional selection for root angle in segregating generations successfully shifted the mean root angle by 30° in the subsequent generation (P ≤ 0.05). Within 18 months, BC2F4:F5 introgr
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- 2022
42. Modulators or facilitators? Roles of lipids in plant root-microbe interactions
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Macabuhay, A, Arsova, B, Walker, R, Johnson, A, Watt, M, Roessner, U, Macabuhay, A, Arsova, B, Walker, R, Johnson, A, Watt, M, and Roessner, U
- Abstract
Lipids have diverse functions in regulating the plasma membrane's cellular processes and signaling mediation. Plasma membrane lipids are also involved in the plant's complex interactions with the surrounding microorganisms, with which plants are in various forms of symbiosis. The roles of lipids influence the whole microbial colonization process, thus shaping the rhizomicrobiome. As chemical signals, lipids facilitate the stages of rhizospheric interactions - from plant root to microbe, microbe to microbe, and microbe to plant root - and modulate the plant's defense responses upon perception or contact with either beneficial or phytopathogenic microorganisms. Although studies have come a long way, further investigation is needed to discover more lipid species and elucidate novel lipid functions and profiles under various stages of plant root-microbe interactions.
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- 2022
43. N-dependent dynamics of root growth and nitrate and ammonium uptake are altered by the bacterium Herbaspirillum seropedicae in the cereal model Brachypodium distachyon
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Janni, M, Kuang, W, Sanow, S, Kelm, JM, Muller Linow, M, Andeer, P, Kohlheyer, D, Northen, T, Vogel, JP, Watt, M, Arsova, B, Janni, M, Kuang, W, Sanow, S, Kelm, JM, Muller Linow, M, Andeer, P, Kohlheyer, D, Northen, T, Vogel, JP, Watt, M, and Arsova, B
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Nitrogen (N) fixation in cereals by root-associated bacteria is a promising solution for reducing use of chemical N fertilizers in agriculture. However, plant and bacterial responses are unpredictable across environments. We hypothesized that cereal responses to N-fixing bacteria are dynamic, depending on N supply and time. To quantify the dynamics, a gnotobiotic, fabricated ecosystem (EcoFAB) was adapted to analyse N mass balance, to image shoot and root growth, and to measure gene expression of Brachypodium distachyon inoculated with the N-fixing bacterium Herbaspirillum seropedicae. Phenotyping throughput of EcoFAB-N was 25-30 plants h-1 with open software and imaging systems. Herbaspirillum seropedicae inoculation of B. distachyon shifted root and shoot growth, nitrate versus ammonium uptake, and gene expression with time; directions and magnitude depended on N availability. Primary roots were longer and root hairs shorter regardless of N, with stronger changes at low N. At higher N, H. seropedicae provided 11% of the total plant N that came from sources other than the seed or the nutrient solution. The time-resolved phenotypic and molecular data point to distinct modes of action: at 5 mM NH4NO3 the benefit appears through N fixation, while at 0.5 mM NH4NO3 the mechanism appears to be plant physiological, with H. seropedicae promoting uptake of N from the root medium.Future work could fine-tune plant and root-associated microorganisms to growth and nutrient dynamics.
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- 2022
44. Root Growth and Architecture of Wheat and Brachypodium Vary in Response to Algal Fertilizer in Soil and Solution
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Mau, L, Junker, S, Bochmann, H, Mihiret, YE, Kelm, JM, Schrey, SD, Roessner, U, Schaaf, G, Watt, M, Kant, J, Arsova, B, Mau, L, Junker, S, Bochmann, H, Mihiret, YE, Kelm, JM, Schrey, SD, Roessner, U, Schaaf, G, Watt, M, Kant, J, and Arsova, B
- Abstract
Alternative, recycled sources for mined phosphorus (P) fertilizers are needed to sustain future crop growth. Quantification of phenotypic adaptations and performance of plants with a recycled nutrient source is required to identify breeding targets and agronomy practices for new fertilization strategies. In this study, we tested the phenotypic responses of wheat (Triticum aestivum) and its genetic model, Brachypodium (Brachypodium distachyon), to dried algal biomass (with algae or high or low mineral P) under three growing conditions (fabricated ecosystems (EcoFABs), hydroponics, and sand). For both species, algal-grown plants had similar shoot biomass to mineral-grown plants, taking up more P than the low mineral P plants. Root phenotypes however were strongly influenced by nutrient form, especially in soilless conditions. Algae promoted the development of shorter and thicker roots, notably first and second order lateral roots. Root hairs were 21% shorter in Brachypodium, but 24% longer in wheat with algae compared to mineral high P. Our results are encouraging to new recycled fertilization strategies, showing algae is a nutrient source to wheat and Brachypodium. Variation in root phenotypes showed algal biomass is sensed by roots and is taken up at a higher amount per root length than mineral P. These phenotypes can be selected and further adapted in phenotype-based breeding for future renewal agriculture systems.
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- 2022
45. Plant Growth Promotion and Heat Stress Amelioration in Arabidopsis Inoculated with Paraburkholderia phytofirmans PsJN Rhizobacteria Quantified with the GrowScreen-Agar II Phenotyping Platform
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Macabuhay, A, Arsova, B, Watt, M, Nagel, KA, Lenz, H, Putz, A, Adels, S, Mueller-Linow, M, Kelm, J, Johnson, AAT, Walker, R, Schaaf, G, Roessner, U, Macabuhay, A, Arsova, B, Watt, M, Nagel, KA, Lenz, H, Putz, A, Adels, S, Mueller-Linow, M, Kelm, J, Johnson, AAT, Walker, R, Schaaf, G, and Roessner, U
- Abstract
High temperatures inhibit plant growth. A proposed strategy for improving plant productivity under elevated temperatures is the use of plant growth-promoting rhizobacteria (PGPR). While the effects of PGPR on plant shoots have been extensively explored, roots-particularly their spatial and temporal dynamics-have been hard to study, due to their below-ground nature. Here, we characterized the time- and tissue-specific morphological changes in bacterized plants using a novel non-invasive high-resolution plant phenotyping and imaging platform-GrowScreen-Agar II. The platform uses custom-made agar plates, which allow air exchange to occur with the agar medium and enable the shoot to grow outside the compartment. The platform provides light protection to the roots, the exposure of it to the shoots, and the non-invasive phenotyping of both organs. Arabidopsis thaliana, co-cultivated with Paraburkholderia phytofirmans PsJN at elevated and ambient temperatures, showed increased lengths, growth rates, and numbers of roots. However, the magnitude and direction of the growth promotion varied depending on root type, timing, and temperature. The root length and distribution per depth and according to time was also influenced by bacterization and the temperature. The shoot biomass increased at the later stages under ambient temperature in the bacterized plants. The study offers insights into the timing of the tissue-specific, PsJN-induced morphological changes and should facilitate future molecular and biochemical studies on plant-microbe-environment interactions.
- Published
- 2022
46. Nutrient deficiency effects on root architecture and root-to-shoot ratio in arable crops.
- Author
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Lopez, G, Ahmadi, SH, Amelung, W, Athmann, M, Ewert, F, Gaiser, T, Gocke, MI, Kautz, T, Postma, J, Rachmilevitch, S, Schaaf, G, Schnepf, A, Stoschus, A, Watt, M, Yu, P, Seidel, SJ, Lopez, G, Ahmadi, SH, Amelung, W, Athmann, M, Ewert, F, Gaiser, T, Gocke, MI, Kautz, T, Postma, J, Rachmilevitch, S, Schaaf, G, Schnepf, A, Stoschus, A, Watt, M, Yu, P, and Seidel, SJ
- Abstract
Plant root traits play a crucial role in resource acquisition and crop performance when soil nutrient availability is low. However, the respective trait responses are complex, particularly at the field scale, and poorly understood due to difficulties in root phenotyping monitoring, inaccurate sampling, and environmental conditions. Here, we conducted a systematic review and meta-analysis of 50 field studies to identify the effects of nitrogen (N), phosphorous (P), or potassium (K) deficiencies on the root systems of common crops. Root length and biomass were generally reduced, while root length per shoot biomass was enhanced under N and P deficiency. Root length decreased by 9% under N deficiency and by 14% under P deficiency, while root biomass was reduced by 7% in N-deficient and by 25% in P-deficient soils. Root length per shoot biomass increased by 33% in N deficient and 51% in P deficient soils. The root-to-shoot ratio was often enhanced (44%) under N-poor conditions, but no consistent response of the root-to-shoot ratio to P-deficiency was found. Only a few K-deficiency studies suited our approach and, in those cases, no differences in morphological traits were reported. We encountered the following drawbacks when performing this analysis: limited number of root traits investigated at field scale, differences in the timing and severity of nutrient deficiencies, missing data (e.g., soil nutrient status and time of stress), and the impact of other conditions in the field. Nevertheless, our analysis indicates that, in general, nutrient deficiencies increased the root-length-to-shoot-biomass ratios of crops, with impacts decreasing in the order deficient P > deficient N > deficient K. Our review resolved inconsistencies that were often found in the individual field experiments, and led to a better understanding of the physiological mechanisms underlying root plasticity in fields with low nutrient availability.
- Published
- 2022
47. ImpACT+, a coping intervention to improve clinical outcomes for women living with HIV and sexual trauma in South Africa:study protocol for a randomized controlled trial
- Author
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Sikkema, K. J., Rabie, S., King, A., Watt, M. H., Mulawa, M. I., Andersen, L. S., Wilson, P. A., Marais, A., Ndwandwa, E., Majokweni, S., Orrell, C., Joska, J. A., Sikkema, K. J., Rabie, S., King, A., Watt, M. H., Mulawa, M. I., Andersen, L. S., Wilson, P. A., Marais, A., Ndwandwa, E., Majokweni, S., Orrell, C., and Joska, J. A.
- Abstract
Background: Addressing sexual trauma in the context of HIV care is essential to improve clinical outcomes and mental health among women in South Africa. Women living with HIV (WLH) report disproportionately high levels of sexual trauma and have higher rates of posttraumatic stress disorder. Adherence to antiretroviral therapy (ART) may be difficult for traumatized women, as sexual trauma compounds the stress associated with managing HIV and is often comorbid with other mental health disorders, further compromising care engagement and adherence. ART initiation represents a unique window of opportunity for intervention to enhance motivation, increase care engagement, and address the negative effects of trauma on avoidant coping behaviors. Mental health interventions delivered by non-specialists in low- and middle-income countries have potential to treat depression, trauma, and effects of intimate partner violence among WLH. This study will examine the effectiveness of Improving AIDS Care after Trauma (ImpACT +), a task-shared, trauma-focused coping intervention, to promote viral suppression among WLH initiating ART in a South African clinic setting. Methods: This study will be conducted in Khayelitsha, a peri-urban settlement situated near Cape Town, South Africa. Using a hybrid type 1 effectiveness-implementation design, we will randomize 350 WLH initiating ART to the ImpACT + experimental condition or the control condition (three weekly sessions of adapted problem-solving therapy) to examine the effectiveness of ImpACT + on viral suppression, ART adherence, and the degree to which mental health outcomes mediate intervention effects. ImpACT + participants will receive six once-a-week coping intervention sessions and six monthly maintenance sessions over the follow-up period. We will conduct mental health and bio-behavioral assessments at baseline, 4, 8, and 12 months, with care engagement data extracted from medical records. We will explore scalability using the C
- Published
- 2022
48. Comparing the Efficacy of Triple Nerve Transfers with Nerve Graft Reconstruction in Upper Trunk Obstetric Brachial Plexus Injury
- Author
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O’Grady, Kathleen M., Power, Hollie A., Olson, Jaret L., Morhart, Michael J., Harrop, A. Robertson, Watt, M. Joe, and Chan, K. Ming
- Published
- 2017
- Full Text
- View/download PDF
49. Effect of two watering regimes on the biomass and leaf Ca and Fe content of four cloned genotypes of Solanum nigrum Linn. at different physiological ages.
- Author
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Shaik, Shakira, Sigamoney, Megan, and Watt, M. Paula
- Subjects
BIOMASS ,AGE ,SOLANUM nigrum ,GENOTYPES ,MOLECULAR cloning - Abstract
Solanum nigrum is an orphan crop known for its medicinal and nutritional value and phenotypic plasticity. Four genotypes, previously identified as accumulating high levels of Ca (G5 and G20) and Fe (G6 and G15), were clonally propagated. Following acclimatization, the clonal progenies were subjected to two watering regimes (50 and 100% water holding capacities) in a greenhouse and clones of each genotype were harvested at 15, 30 and 45 days of ex-vitro growth. Full water supply and aging led to the greatest biomass production by the clonal genotypes while both watering regimes resulted in overall increases in leaf water contents. Ca and Fe contents were not affected by age or changing water availability except for the G6 clones which accumulated less Fe under water stress. Genotypic variations occurred for all tested parameters except Fe content (full water supply), and Ca content, root fresh and dry weights (water stress). With age, plasticities for biomass increased, those for leaf water content decreased and remained unaffected for Ca and Fe contents. Genotypic effects were observed for shoot and root dry weight plasticities (G6 > G15). The clones of G5, G6 and G20 could be grown at 50% WHC and harvested after 15 days of ex-vitro growth as full plants for consumption but since shoot biomass was found to be a critical factor influencing Ca and Fe content, a greater number of clones will need to be propagated to gain the maximum nutritional benefit at day 15. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
50. Somatic Embryogenesis in Eucalyptus grandis and E. dunni
- Author
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Watt, M. P., Blakeway, F. C., Termignoni, R., Jain, S. M., Jain, S. Mohan, editor, Gupta, Pramod K., editor, and Newton, Ronald J., editor
- Published
- 1999
- Full Text
- View/download PDF
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