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128 results on '"Watt, F.M."'

1. LB1674 A roadmap for the human skin cell atlas

Author

Almet, A., primary, Yuan, H., additional, Annusver, K., additional, Ramos, R., additional, Liu, Y., additional, Wiedemann, J., additional, Sorkin, D., additional, Landén, N. Xu, additional, Sonkoly, E., additional, Haniffa, M., additional, Nie, Q., additional, Lichtenberger, B.M., additional, Luecken, M., additional, Andersen, B., additional, Tsoi, L., additional, Watt, F.M., additional, Gudjonsson, J., additional, Plikus, M., additional, and Kasper, M., additional

Published
2023
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3. 1376 A multi-scale spatial atlas of human skin links cancer cell states to site of origin

Author

Ganier, C., primary, Du-Harpur, B., additional, Herrera-Oropeza, G., additional, Mazin, P., additional, Predeus, A., additional, Gabriel, J., additional, Harun, N., additional, Blakeley, M., additional, Darrigrand, J., additional, Haiser, A., additional, Wyles, S., additional, Shaw, T.J., additional, Teichmann, S., additional, Haniffa, M., additional, Watt, F.M., additional, and Lynch, M., additional

Published
2023
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6. ISSCR Presidents look back on their presidency, the evolution of the field, and the Society

Author

Zon, L., Keller, G., Daley, G.Q., Watt, F.M., Weissman, I.L., Fuchs, E., Gage, F.H., Yamanaka, S., Rossant, J., Morrison, S., Temple, S., Clevers, H.C., Srivastava, D., Mummery, C.L., and Little, M.

Abstract

In celebration of the ISSCR's 20th anniversary we asked past ISSCR presidents the question, "During your presidential year, what key achievements or issue(s) in the field stood out to you?'' The collection of responses provides a glimpse of the evolution of the field and the ISSCR over the past 20 years.

Published
2022

8. Indian hedgehog and [beta]-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis

Author

Niemann, C., Unden, A.B., Lyle, S., Zouboulis, Ch. C., Toftgard, R., and Watt, F.M.

Subjects
Cellular signal transduction -- Physiological aspects, Epidermis -- Physiological aspects, Gene expression -- Physiological aspects, Science and technology
Abstract

In mammalian epidermis, the level of [beta]-catenin signaling regulates lineage selection by stem cell progeny. High levels of [beta]-catenin stimulate formation of hair follicles, whereas low levels favor differentiation into interfollicular epidermis and sebocytes. In transgenic mouse epidermis, overexpression of [beta]-catenin leads to formation of hair follicle tumors, whereas overexpression of N-terminally truncated Lef1, which blocks [beta]-catenin signaling, results in spontaneous sebaceous tumors. Accompanying overexpression of [beta]-catenin is up-regulation of Sonic hedgehog (SHH) and its receptor, Patched (PTCH/Ptch). In [DELTA]NLef1 tumors Ptch mRNA is up-regulated in the absence of SHH. We now show that PTCH is up-regulated in both human and mouse sebaceous tumors and is accompanied by overexpression of Indian hedgehog (IHH). In normal sebaceous glands IHH is expressed in differentiated sebocytes and the transcription factor GLI1 is activated in sebocyte progenitors, suggesting a paracrine signaling mechanism. PTCH1 and IHH are up-regulated during human sebocyte differentiation in vitro and inhibition of hedgehog signaling inhibits growth and stimulates differentiation. Overexpression of [DELTA]ANLef1 up-regulates IHH and stimulates proliferation of undifferentiated sebocytes. We present a model of the interactions between [beta]-catenin and hedgehog signaling in the epidermis in which SHH promotes proliferation of progenitors of the hair lineages whereas IHH stimulates proliferation of sebocyte precursors.

Published
2003

10. Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

Author

Tziotzios, C., Petridis, C., Dand, N., Ainali, C., Saklatvala, J.R., Pullabhatla, V., Onoufriadis, A., Pramanik, R., Baudry, D., Lee, S.H., Wood, K., Liu, L., Seegobin, S., Michelotti, G.A., Lwin, S.M., Christou, E.A.A., Curtis, C.J.., de Rinaldis, E., Saxena, A., Holmes, S., Harries, M., Palamaras, I., Cunningham, F., Parkins, G., Kaur, M., Farrant, P., McDonagh, A., Messenger, A., Jones, J., Jolliffe, V., Ali, I., Ardern-Jones, M., Mitchell, C., Burrows, N., Atkar, R., Banfield, C., Alexandroff, A., Champagne, C., Cooper, H.L., Vano-Galvan, S., Maria Molina-Ruiz, A., Ormaechea Perez, N., Patel, G.K., Macbeth, A., Page, M., Bryden, A., Mowbray, M., Wahie, S., Armstrong, K., Cooke, N., Goodfield, M., Man, I., de Berker, D., Dunnill, G., Takwale, A., Rao, A., Siah, T.-W., Sinclair, R., Wade, M.S., Dlova, N.C., Setterfield, J., Lewis, F., Bhargava, K., Kirkpatrick, N., Estivill, X., Stefanato, C.M., Flohr, C., Spector, T., Watt, F.M., Smith, C.H., Barker, J.N., Fenton, D.A., Simpson, M.A., and McGrath, J.A.

Abstract

Frontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively women. Despite a dramatic recent increase in incidence the aetiopathogenesis of FFA remains unknown. We undertake genome-wide association studies in females from a UK cohort, comprising 844 cases and 3,760 controls, a Spanish cohort of 172 cases and 385 controls, and perform statistical meta-analysis. We observe genome-wide significant association with FFA at four genomic loci: 2p22.2, 6p21.1, 8q24.22 and 15q2.1. Within the 6p21.1 locus, fine-mapping indicates that the association is driven by the HLA-B*07:02 allele. At 2p22.1, we implicate a putative causal missense variant in CYP1B1, encoding the homonymous xenobiotic- and hormone-processing enzyme. Transcriptomic analysis of affected scalp tissue highlights overrepresentation of transcripts encoding components of innate and adaptive immune response pathways. These findings provide insight into disease pathogenesis and characterise FFA as a genetically predisposed immuno-inflammatory disorder driven by HLA-B*07:02.

Published
2019

11. Applications and future directions for optical coherence tomography in dermatology.

Author

Wan, B., Ganier, C., Du‐Harpur, X., Harun, N., Watt, F.M., Patalay, R., and Lynch, M.D.

Subjects
OPTICAL coherence tomography, ARTIFICIAL intelligence, CONNECTIVE tissue diseases, DERMATOLOGY, BASAL cell carcinoma, SKIN cancer, PSORIATIC arthritis
Abstract

Summary: Optical coherence tomography (OCT) is a noninvasive optical imaging method that can generate high‐resolution en face and cross‐sectional images of the skin in vivo to a maximum depth of 2 mm. While OCT holds considerable potential for noninvasive diagnosis and disease monitoring, it is poorly understood by many dermatologists. Here we aim to equip the practising dermatologist with an understanding of the principles of skin OCT and the potential clinical indications. We begin with an introduction to the technology and discuss the different modalities of OCT including angiographic (dynamic) OCT, which can image cutaneous blood vessels at high resolution. Next we review clinical applications. OCT has been most extensively investigated in the diagnosis of keratinocyte carcinomas, particularly basal cell carcinoma. To date, OCT has not proven sufficiently accurate for the robust diagnosis of malignant melanoma; however, the evaluation of abnormal vasculature with angiographic OCT is an area of active investigation. OCT, and in particular angiographic OCT, also shows promise in monitoring the response to therapy of inflammatory dermatoses, such as psoriasis and connective tissues disease. We additionally discuss a potential role for artificial intelligence in improving the accuracy of interpretation of OCT imaging data. [ABSTRACT FROM AUTHOR]

Published
2021
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16. 581 A genome-wide screen identifies YAP/WBP2/TEAD interplay conferring growth advantage on human epidermal stem cells

Author

Walko, G., primary, Woodhouse, S., additional, Oliveira Pisco, A., additional, Rognoni, E., additional, Liakath-Ali, K., additional, Lichtenberger, B.M., additional, Mishra, A., additional, Telerman, S., additional, Viswanathan, P., additional, Logtenberg, M., additional, Renz, L., additional, Quist, S., additional, and Watt, F.M., additional

Published
2019
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28. Extracellular-matrix tethering regulates stem-cell fate

Author

Trappmann, B., Gautrot, J.E., Connelly, J.T., Strange, D.G.T., Li, Y., Oyen, M.L., Stuart, M.A.C., Boehm, H., Li, B.J., Vogel, V., Spatz, J.P., Watt, F.M., Huck, W.T.S., Trappmann, B., Gautrot, J.E., Connelly, J.T., Strange, D.G.T., Li, Y., Oyen, M.L., Stuart, M.A.C., Boehm, H., Li, B.J., Vogel, V., Spatz, J.P., Watt, F.M., and Huck, W.T.S.

Abstract

Contains fulltext : 93852.pdf (publisher's version ) (Closed access)

Published
2012

30. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

Author

Wong, V.M., Stange, D.E., Page, M.E., Buczacki, S., Wabik, A., Itami, S., van de Wetering, M., Poulsom, R., Wright, N.A., Trotter, M.W., Watt, F.M., Winton, D.J., Clevers, H., Jensen, K.B., Wong, V.M., Stange, D.E., Page, M.E., Buczacki, S., Wabik, A., Itami, S., van de Wetering, M., Poulsom, R., Wright, N.A., Trotter, M.W., Watt, F.M., Winton, D.J., Clevers, H., and Jensen, K.B.

Abstract

Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback regulation of instructive extrinsic and intrinsic signals. ErbB signalling is a prerequisite for maintenance of the intestinal epithelium following injury and tumour formation. As ErbB-family ligands and receptors are highly expressed within the stem-cell niche, we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. Here we show that Lrig1, a negative-feedback regulator of the ErbB receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling. Intestinal stem-cell maintenance has so far been attributed to a combination of Wnt and Notch activation and Bmpr inhibition. Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. This has implications for our understanding of ErbB signalling in tissue development and maintenance and the progression of malignant disease., Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback regulation of instructive extrinsic and intrinsic signals. ErbB signalling is a prerequisite for maintenance of the intestinal epithelium following injury and tumour formation. As ErbB-family ligands and receptors are highly expressed within the stem-cell niche, we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. Here we show that Lrig1, a negative-feedback regulator of the ErbB receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling. Intestinal stem-cell maintenance has so far been attributed to a combination of Wnt and Notch activation and Bmpr inhibition. Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. This has implications for our understanding of ErbB signalling in tissue development and maintenance and the progression of malignant disease.

Published
2012

31. Extracellular-matrix tethering regulates stem-cell fate (vol 11, pg 642, 2012)

Author

Trappmann, B., Gautrot, J.E., Connelly, J.T., Strange, D.G.T., Li, Y., Oyen, M.L., Stuart, M.A.C., Boehm, H., Li, B.J., Vogel, V., Spatz, J.P., Watt, F.M., Huck, W.T.S., Trappmann, B., Gautrot, J.E., Connelly, J.T., Strange, D.G.T., Li, Y., Oyen, M.L., Stuart, M.A.C., Boehm, H., Li, B.J., Vogel, V., Spatz, J.P., Watt, F.M., and Huck, W.T.S.

Abstract

Item does not contain fulltext

Published
2012

41. Envoplakin, a Possible Candidate Gene for Focal NEPPK/Esophageal Cancer (TOC): The Integration of Genetic and Physical Maps of the TOC Region on 17q25

Author

Risk, J.M., primary, Ruhrberg, C., additional, Hennies, H.-C., additional, Mills, H.S., additional, Di Colandrea, T., additional, Evans, K.E., additional, Ellis, A., additional, Watt, F.M., additional, Bishop, D.T., additional, Spurr, N.K., additional, Stevens, H.P., additional, Leigh, I.M., additional, Reis, A., additional, Kelsell, D.P., additional, and Field, J.K., additional

Published
1999
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