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543 results on '"Watson, D. I."'

6. Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer:a modified Delphi consensus process

Author

Chidambaram, S. (Swathikan), Patel, N. M. (Nikhil M.), Sounderajah, V. (Viknesh), Alfieri, R. (Rita), Bonavina, L. (Luigi), Cheong, E. (Edward), Cockbain, A. (Andy), D’Journo, X. B. (Xavier Benoit), Ferri, L. (Lorenzo), Griffiths, E. A. (Ewen A.), Grimminger, P. (Peter), Gronnier, C. (Caroline), Gutschow, C. (Christian), Hedberg, J. (Jakob), Kauppila, J. H. (Joonas H.), Lagarde, S. (Sjoerd), Low, D. (Donald), Nafteux, P. (Philippe), Nieuwenhuijzen, G. (Grard), Nilsson, M. (Magnus), Rosati, R. (Riccardo), Schroeder, W. (Wolfgang), Smithers, B. M. (B. Mark), van Berge Henegouwen, M. I. (Mark I.), van Hillegesberg, R. (Richard), Watson, D. I. (David I.), Vohra, R. (Ravinder), Maynard, N. (Nick), Markar, S. R. (Sheraz R.), Chidambaram, S. (Swathikan), Patel, N. M. (Nikhil M.), Sounderajah, V. (Viknesh), Alfieri, R. (Rita), Bonavina, L. (Luigi), Cheong, E. (Edward), Cockbain, A. (Andy), D’Journo, X. B. (Xavier Benoit), Ferri, L. (Lorenzo), Griffiths, E. A. (Ewen A.), Grimminger, P. (Peter), Gronnier, C. (Caroline), Gutschow, C. (Christian), Hedberg, J. (Jakob), Kauppila, J. H. (Joonas H.), Lagarde, S. (Sjoerd), Low, D. (Donald), Nafteux, P. (Philippe), Nieuwenhuijzen, G. (Grard), Nilsson, M. (Magnus), Rosati, R. (Riccardo), Schroeder, W. (Wolfgang), Smithers, B. M. (B. Mark), van Berge Henegouwen, M. I. (Mark I.), van Hillegesberg, R. (Richard), Watson, D. I. (David I.), Vohra, R. (Ravinder), Maynard, N. (Nick), and Markar, S. R. (Sheraz R.)

Abstract

Summary Background: There is currently a lack of evidence-based guidelines regarding surveillance for recurrence after esophageal and gastric (OG) cancer surgical resection, and which symptoms should prompt endoscopic or radiological investigations for recurrence. The aim of this study was to develop a core symptom set using a modified Delphi consensus process that should guide clinicians to carry out investigations to look for suspected recurrent OG cancer in previously asymptomatic patients. Methods: A web-based survey of 42 questions was sent to surgeons performing OG cancer resections at high volume centers. The first section evaluated the structure of follow-up and the second, determinants of follow-up. Two rounds of a modified Delphi consensus process and a further consensus workshop were used to determine symptoms warranting further investigations. Symptoms with a 75% consensus agreement as suggestive of recurrent cancer were included in the core symptom set. Results: 27 surgeons completed the questionnaires. A total of 70.3% of centers reported standardized surveillance protocols, whereas 3.7% of surgeons did not undertake any surveillance in asymptomatic patients after OG cancer resection. In asymptomatic patients, 40.1% and 25.9% of centers performed routine imaging and endoscopy, respectively. The core set that reached consensus, consisted of eight symptoms that warranted further investigations included; dysphagia to solid food, dysphagia to liquids, vomiting, abdominal pain, chest pain, regurgitation of foods, unexpected weight loss and progressive hoarseness of voice. Conclusion: There is global variation in monitoring patients after OG cancer resection. Eight symptoms were identified by the consensus process as important in prompting radiological or endoscopic investigation for suspected recurrent malignancy. Further randomized controlled trials are necessary to link surveillance strategies to survival outcomes and evaluate prognostic value.

Published
2022

9. Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus

Author

Mueller, P. C., Kapp, J. R., Vetter, D., Bonavina, L., Brown, W., Castro, S., Cheong, E., Darling, G. E., Egberts, J., Ferri, L., Gisbertz, S. S., Gockel, I, Grimminger, P. P., Hofstetter, W. L., Hoelscher, A. H., Low, D. E., Luyer, M., Markar, S. R., Moenig, S. P., Moorthy, K., Morse, C. R., Mueller-Stich, B. P., Nafteux, P., Nieponice, A., Nieuwenhuijzen, G. A. P., Nilsson, M., Palanivelu, C., Pattyn, P., Pera, M., Rasanen, J., Ribeiro, U., Rosman, C., Schroeder, W., Sgromo, B., van Berge Henegouwen, M., I, van Hillegersberg, R., van Veer, H., van Workum, F., Watson, D., I, Wijnhoven, B. P. L., Gutschow, C. A., Mueller, P. C., Kapp, J. R., Vetter, D., Bonavina, L., Brown, W., Castro, S., Cheong, E., Darling, G. E., Egberts, J., Ferri, L., Gisbertz, S. S., Gockel, I, Grimminger, P. P., Hofstetter, W. L., Hoelscher, A. H., Low, D. E., Luyer, M., Markar, S. R., Moenig, S. P., Moorthy, K., Morse, C. R., Mueller-Stich, B. P., Nafteux, P., Nieponice, A., Nieuwenhuijzen, G. A. P., Nilsson, M., Palanivelu, C., Pattyn, P., Pera, M., Rasanen, J., Ribeiro, U., Rosman, C., Schroeder, W., Sgromo, B., van Berge Henegouwen, M., I, van Hillegersberg, R., van Veer, H., van Workum, F., Watson, D., I, Wijnhoven, B. P. L., and Gutschow, C. A.

Abstract

There are no internationally recognized criteria available to determine preparedness for hospital discharge after esophagectomy. This study aims to achieve international consensus using Delphi methodology. The expert panel consisted of 40 esophageal surgeons spanning 16 countries and 4 continents. During a 3-round, web-based Delphi process, experts voted for discharge criteria using 5-point Likert scales. Data were analyzed using descriptive statistics. Consensus was reached if agreement was >= 75% in round 3. Consensus was achieved for the following basic criteria: nutritional requirements are met by oral intake of at least liquids with optional supplementary nutrition via jejunal feeding tube. The patient should have passed flatus and does not require oxygen during mobilization or at rest. Central venous catheters should be removed. Adequate analgesia at rest and during mobilization is achieved using both oral opioid and non-opioid analgesics. All vital signs should be normal unless abnormal preoperatively. Inflammatory parameters should be trending down and close to normal (leucocyte count <= 12G/l and C-reactive protein <= 80 mg/dl). This multinational Delphi survey represents the first expert-led process for consensus criteria to determine 'fit-for-discharge' status after esophagectomy. Results of this Delphi survey may be applied to clinical outcomes research as an objective measure of short-term recovery. Furthermore, standardized endpoints identified through this process may be used in clinical practice to guide decisions regarding patient discharge and may help to reduce the risk of premature discharge or prolonged admission.

Published
2021

10. Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus

Author

MS CGO, Cancer, Müller, P. C., Kapp, J. R., Vetter, D., Bonavina, L., Brown, W., Castro, S., Cheong, E., Darling, G. E., Egberts, J., Ferri, L., Gisbertz, S. S., Gockel, I., Grimminger, P. P., Hofstetter, W. L., Hölscher, A. H., Low, D. E., Luyer, M., Markar, S. R., Mönig, S. P., Moorthy, K., Morse, C. R., Müller-Stich, B. P., Nafteux, P., Nieponice, A., Nieuwenhuijzen, G. A.P., Nilsson, M., Palanivelu, C., Pattyn, P., Pera, M., Räsänen, J., Ribeiro, U., Rosman, C., Schröder, W., Sgromo, B., Van Berge Henegouwen, M. I., Van Hillegersberg, R., Van Veer, H., Van Workum, F., Watson, D. I., Wijnhoven, B. P.L., Gutschow, C. A., MS CGO, Cancer, Müller, P. C., Kapp, J. R., Vetter, D., Bonavina, L., Brown, W., Castro, S., Cheong, E., Darling, G. E., Egberts, J., Ferri, L., Gisbertz, S. S., Gockel, I., Grimminger, P. P., Hofstetter, W. L., Hölscher, A. H., Low, D. E., Luyer, M., Markar, S. R., Mönig, S. P., Moorthy, K., Morse, C. R., Müller-Stich, B. P., Nafteux, P., Nieponice, A., Nieuwenhuijzen, G. A.P., Nilsson, M., Palanivelu, C., Pattyn, P., Pera, M., Räsänen, J., Ribeiro, U., Rosman, C., Schröder, W., Sgromo, B., Van Berge Henegouwen, M. I., Van Hillegersberg, R., Van Veer, H., Van Workum, F., Watson, D. I., Wijnhoven, B. P.L., and Gutschow, C. A.

Published
2021

12. Additional file 7 of Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma

Author

Mayne, G. C., Woods, C. M., Dharmawardana, N., Wang, T., Krishnan, S., Hodge, J. C., Foreman, A., Boase, S., Carney, A. S., Sigston, E. A. W., Watson, D. I., Ooi, E. H., and Hussey, D. J.

Abstract

Additional file 7. Details of all differentially expressed house keeping gene normalized miRNAs (non-cancer vs cancer).

Published
2020
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13. Additional file 8 of Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma

Author

Mayne, G. C., Woods, C. M., Dharmawardana, N., Wang, T., Krishnan, S., Hodge, J. C., Foreman, A., Boase, S., Carney, A. S., Sigston, E. A. W., Watson, D. I., Ooi, E. H., and Hussey, D. J.

Abstract

Additional file 8. Details of non-differentially expressed miRNAs present in the 11 miRNA-ratios logistic regression model.

Published
2020
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14. Additional file 9 of Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma

Author

Mayne, G. C., Woods, C. M., Dharmawardana, N., Wang, T., Krishnan, S., Hodge, J. C., Foreman, A., Boase, S., Carney, A. S., Sigston, E. A. W., Watson, D. I., Ooi, E. H., and Hussey, D. J.

Abstract

Additional file 9. Boxplots of the differentially expressed miRNAs in the 11-miRNA-ratio logistic regression model.

Published
2020
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19. Additional file 3 of Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma

Author

Mayne, G. C., Woods, C. M., Dharmawardana, N., Wang, T., Krishnan, S., Hodge, J. C., Foreman, A., Boase, S., Carney, A. S., Sigston, E. A. W., Watson, D. I., Ooi, E. H., and Hussey, D. J.

Subjects
Statistics::Theory, Statistics::Machine Learning, Statistics::Methodology, Astrophysics::Galaxy Astrophysics, Statistics::Computation
Abstract

Additional file 3. List of all lasso regression miR-ratios selected from the inner cross validation loop.

Published
2020
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41. Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus

Author

Müller, P C, primary, Kapp, J R, additional, Vetter, D, additional, Bonavina, L, additional, Brown, W, additional, Castro, S, additional, Cheong, E, additional, Darling, G E, additional, Egberts, J, additional, Ferri, L, additional, Gisbertz, S S, additional, Gockel, I, additional, Grimminger, P P, additional, Hofstetter, W L, additional, Hölscher, A H, additional, Low, D E, additional, Luyer, M, additional, Markar, S R, additional, Mönig, S P, additional, Moorthy, K, additional, Morse, C R, additional, Müller-Stich, B P, additional, Nafteux, P, additional, Nieponice, A, additional, Nieuwenhuijzen, G A P, additional, Nilsson, M, additional, Palanivelu, C, additional, Pattyn, P, additional, Pera, M, additional, Räsänen, J, additional, Ribeiro, U, additional, Rosman, C, additional, Schröder, W, additional, Sgromo, B, additional, van Berge Henegouwen, M I, additional, van Hillegersberg, R, additional, van Veer, H, additional, van Workum, F, additional, Watson, D I, additional, Wijnhoven, B P L, additional, and Gutschow, C A, additional

Published
2020
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43. Risk factors for delayed gastric emptying following laparoscopic repair of very large hiatus hernias

Author

Tog, C., Liu, D. S., Lim, H. K., Stiven, P., Thompson, S. K., Watson, D. I., and Aly, A.

Subjects
digestive, oral, and skin physiology, Original Article, Original Articles, digestive system diseases
Abstract

Background Delayed gastric emptying can complicate surgery for hiatus hernia. The aim of this study was to quantify its incidence following laparoscopic repair of very large hiatus hernias, identify key risk factors for its occurrence and determine its impact on clinical outcomes. Methods Data collected from a randomized trial of patients who underwent laparoscopic mesh versus sutured repair of very large hiatus hernias (more than 50 per cent of stomach in chest) were analysed retrospectively. Delayed gastric emptying was defined as endoscopic evidence of solid food in the stomach after fasting for 6 h at 6 months after surgery. Results Delayed gastric emptying occurred in 19 of 102 patients (18·6 per cent). In univariable analysis, type 2 paraoesophageal hernia (relative risk (RR) 3·15, 95 per cent c.i. 1·41 to 7·06), concurrent anterior and posterior hiatal repair (RR 2·66, 1·14 to 6·18), hernia sac excision (RR 4·85, 1·65 to 14·24), 270°/360° fundoplication (RR 3·64, 1·72 to 7·68), division of short gastric vessels (RR 6·82, 2·12 to 21·90) and revisional surgery (RR 3·69, 1·73 to 7·87) correlated with delayed gastric emptying. In multivariable analysis, division of short gastric vessels (RR 6·27, 1·85 to 21·26) and revisional surgery (RR 6·19, 1·32 to 28·96) were independently associated with delayed gastric emptying. Delayed gastric emptying correlated with adverse gastrointestinal symptomatology, including higher rates of bloating, nausea, vomiting and anorexia, as well as reduced patient satisfaction with the operation and recovery. Conclusion Delayed gastric emptying following large hiatus hernia repair is common and associated with adverse symptoms and reduced patient satisfaction. Division of short gastric vessels and revisional surgery were independently associated with its occurrence.

Published
2017

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