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Human epidermal growth factor receptor‐2 (HER2), programmed death‐ligand 1 (PD‐L1), and microsatellite (MS) status are well‐established biomarkers in gastroesophageal adenocarcinomas (GEAs). However, it is unclear how the combination of these biomarkers is associated with clinicopathological factors and prognosis. This retrospective study included baseline metastatic GEA patients who were tested for all three biomarkers (HER2, PD‐L1, and MS status) at the MD Anderson Cancer Center between 2012 and 2022. Stratification was performed according to the combination of biomarker profiles: triple negative (TN), single positive (SP), and multiple positive (MP). Comparative analyses of clinicopathological factors and survival using combinations of biomarkers were performed. Among the 698 GEA patients analyzed, 251 (36.0%) were classified as TN, 334 (47.9%) as SP, and 113 (16.1%) as MP. The MP group showed a significant association with tumors located in the esophagus (p <.001), well to moderate differentiation (p <.001), and the absence of signet ring cells (p <.001). In the survival analysis, MP group had a significantly longer overall survival (OS) compared to the other groups (MP vs. TN, p <.001 and MP vs. SP, p <.001). Multivariate Cox regression analysis revealed that MP serves as an independent positive prognostic indicator for OS (hazard ratio = 0.63, p <.01). Our findings indicate that MP biomarkers are associated with a favorable prognosis in metastatic GEA. These results are reflective of clinical practice and offer valuable insights into how therapeutics and future biomarkers could influence therapy/prognosis. [ABSTRACT FROM AUTHOR]

Background: Few studies discuss social inclusion from the voice and perspective of young adults with intellectual disability who have been lifelong recipients of individualised community-based coordination and services focusing on inclusion and participation. It is important to understand the perspective of people with an intellectual disability how they experience and perceive social inclusion within their own lives. Method: Ten participants aged 18 to 24 years diagnosed with intellectual disability living in the community alone, or with their family, participated. All received long-term individualised community-based coordination and services. They were interviewed about how they spend their time, form relationships, and feel included. A phenomenological approach was used with a thematic analysis to form codes from transcripts into two major themes. Results: Young adults within this study experienced feelings of segregation and exclusion from community. Participants experienced trouble finding employment and were frequently bored. Social interactions were mainly with family and others with a disability in formal programs. Conclusions: Despite being long-term recipients of individualised community-based coordination the young adults discussed significant experiences of segregation and exclusion impacting negatively on their lives.

This article reports on a scoping review exploring understandings of family and domestic violence (FDV) against women with disability (WWD) within the literature and constitutes the second article in a two-part series, the first critiquing the categorization and measurement of FDV and disability. We report findings from qualitative studies included in the review, predominantly interpretivist and critical in orientation. The scoping review included 43 articles, 15 of which are included here, as they draw upon data directly from the perspectives of WWD. Reflexive thematic analysis was conducted, utilizing both inductive and deductive coding, and consultation between the authors. The analysis highlighted experiences of disability-based abuse, the nexus of ableism and sexism within the everyday, and meanings of justice and resilience for WWD. Disability-based abuse was perpetrated primarily by intimate partners, including financial and physical disability-based abuse, and was used to exploit and perpetuate situations of isolation. Sexist and ableist expectations, assumptions, and attitudes converged in everyday encounters within the community, with workers and systems. However, WWD reported strategies of resistance, healing, coping, and moving on in the aftermath of FDV and indicated what can be done to promote justice, both personally and within systems. The findings were discussed drawing on Axel Honneth's theory of recognition to highlight the mechanisms by which recognition and respect can be enhanced to enable full access to citizenship, in particular, for WWD to live free from violence. [ABSTRACT FROM AUTHOR]

Background: Social inclusion is a vital domain in quality of life and is enhanced through recreational programs. People with intellectual disability have been provided with fewer opportunities to participate in these groups, thus hindering social inclusion. Method: Five databases (CINAHL, Ovid, ProQuest, ScienceDirect, and Wiley Online Library) were electronically searched and narrowed using inclusion/exclusion criteria. The methodological quality was assessed using standard quality assessment criteria. Results: Out of 135 retrieved results, 12 articles were included. Data were predominantly collected using questionnaires, scales, and interviews. Ages of the people with intellectual disability ranged from 5 to 65 years, and the sample size ranged from 30 to 2,556 persons. Four key themes became apparent in the literature: (1) the impact of physical and social independence, (2) the amount of social interaction and participation, (3) the impact of culture and attitudes, and (4) the outcomes of social inclusion. Conclusions: Social inclusion and participation in leisure activities for people with intellectual disability increase with greater functional independence and positive community attitudes. This participation results in positive outcomes. People with an intellectual disability participate less in recreational programs. Further research is needed regarding the experience from the person's point of view.

Family violence may be experienced at any stage of the lifespan; however, these experiences are often understood differently based on the age of the victim and who perpetrates the abuse. The significance of age is evident in the three categories of child abuse, domestic and family violence (DFV), and elder abuse. Each of these categories has its own definition which determines who is considered a victim or a perpetrator, and the behaviors counted as violent and abusive. These definitions influence how practitioners view victim-survivors' experiences of violence, and the subsequent available responses. This article reports the findings of a scoping review of international literature published between 2011 and 2021, which explored how family violence is categorized and defined. The review was conducted as part of a larger study exploring how violence against women in intimate and family contexts is conceptualized and experienced, as well as the available responses. Forty-eight articles were included in the final review, and five categories of violence in family and intimate contexts were identified. These were child abuse, DFV, elder abuse, adolescent-to-parent violence, and sibling abuse. Comparison of definitions across categories found similarities in terms of the relationship between victim and perpetrator, behavior, intention, and harm caused to the victim. Review findings suggest that definitions of various forms of family violence do not differ greatly. Further research is needed to determine whether responses to family violence across the lifespan can and should be streamlined. [ABSTRACT FROM AUTHOR]

Helping professionals are at risk of experiencing adverse health and psychological problems when working in roles where they are continually exposed to the emotional distress of others. The term compassion fatigue was coined to describe symptoms of emotional and physical fatigue experienced by workers in these environments. However, empirical research contends that compassion does not cause fatigue, rather compassion is said to foster well-being and is neurologically rejuvenating. The objective of this review was to examine the scientific literature which investigated the compassion-enhancing practice of loving kindness meditation (LKM). This review suggests that LKM can be seen as an alternate strategy to reduce stress, ease empathic distress, and increase positive affect. [ABSTRACT FROM AUTHOR]

Rebecca Waters recommends sustainable solutions for waste management. [ABSTRACT FROM AUTHOR]

Rebecca Waters outlines the leading principles of waste management. [ABSTRACT FROM AUTHOR]

Rebecca Waters considers the vital importance of hand hygiene in dentistry. [ABSTRACT FROM AUTHOR]