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90 results on '"Watanabe, Yoshiya"'

1. Photometry of Type II Supernova SN 2023ixf with a Worldwide Citizen Science Network

Author

Sgro, Lauren A., Esposito, Thomas M., Blaclard, Guillaume, Gomez, Sebastian, Marchis, Franck, Filippenko, Alexei V., Peluso, Daniel O'Conner, Lawrence, Stephen S., Verveen, Aad, Wagner, Andreas, Nardi, Anouchka, Wiart, Barbara, Mirwald, Benjamin, Christensen, Bill, Eramia, Bob, Parker, Bruce, Guillet, Bruno, Kim, Byungki, Logan, Chelsey A., Kyba, Christopher C. M., Toulmin, Christopher, Vantaggiato, Claudio G., Adhis, Dana, Gary, Dave, Goodey, Dave, Dickinson, David, Koster, David, Martin, Davy, Bonilla, Eliud, Chung, Enner, Miny, Eric, Mortecrette, Fabrice, Saibi, Fadi, Gagnon, Francois O., Simard, François, Vacon, Gary, Simard, Georges, Dreise, Gerrit, Funakoshi, Hiromi, Vacon, Janet, Yaniz, James, Tarnec, Jean-Charles Le, Laugier, Jean-Marie, Siders, Jennifer L. W., Sweitzer, Jim, Dvoracek, Jiri, Archer, John, Deitz, John, Bradley, John K., Fukui, Keiichi, Sibbernsen, Kendra, Borrot, Kevin, Cross, Kevin, Heider, Kevin, Yamaguchi, Koichi, Hirsch, Lea A., Leroux, Liouba, Billiani, Mario, Lorber, Markus, Smallen, Martin J., Shimizu, Masao, Nishimura, Masayoshi, Ryno, Matthew, Cunningham, Michael, Gagnon, Michael, Primm, Michael, Rushton, Michael, Sibbernsen, Michael, Mitchell, Mike, Yoblonsky, Neil, Leroux, Niniane, Clerget, Olivier, Stojanović, Ozren, Unique, Patrice, Huth, Patrick, Ang, Raymund John, Santoni, Regis, Foster, Robert, Poggiali, Roberto, Xu, Ruyi, Kukita, Ryuichi, Šćepanović, Sanja, Saibi, Sophie, Will, Stefan, Latour, Stephan, Haythornthwaite, Stephen, Cadieux, Sylvain, Müller, Thoralf, Chung, Tze Yang, Watanabe, Yoshiya, and Arnaud, Yvan

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present highly sampled photometry of the supernova (SN) 2023ixf, a Type II SN in M101, beginning 2 days before its first known detection. To gather these data, we enlisted the global Unistellar Network of citizen scientists. These 252 observations from 115 telescopes show the SN's rising brightness associated with shock emergence followed by gradual decay. We measure a peak $M_{V}$ = -18.18 $\pm$ 0.09 mag at 2023-05-25 21:37 UTC in agreement with previously published analyses., Comment: 4 pages, 1 figure

Published
2023
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3. Oral Ingestion of Yuzu Seed Oil Suppresses the Development of Atopic Dermatitis-like Skin Lesions in NC/Nga Mice.

Author

Asano, Kimito, Watanabe, Yoshiya, Miyamoto, Mio, Toutani, Mochifumi, and Mizobuchi, Shunji

Subjects
*IMMUNOGLOBULIN E, *MICE, *NUCLEAR factor E2 related factor, *OILSEEDS
Abstract

Long-term oral ingestion of unheated yuzu seed oil in humans reduces lipid peroxides in the blood. Moreover, yuzu seed oil contains limonin, which can induce antioxidant and anti-inflammatory effects by activating the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Previously, Nrf2 has been shown to reduce atopic dermatitis (AD). Therefore, we hypothesized that ingesting unheated yuzu seed oil can regulate AD through Nrf2. An AD model was established using NC/Nga mice through repeated local exposure to mite antigens. Unheated and purified yuzu seed oil (100 µL/mice) or water (control, 100 µL/mice) was administered orally once a day using a gastric cannula for rodents for 28 days. On day 28, mice in the unheated yuzu seed oil group exhibited significantly lower clinical skin severity scores and ear thickness than those in the purified yuzu seed oil and water groups. Serum histamine levels remained unaltered among the three AD-induced groups. Serum Dermatophagoides farina body (Dfb)-specific immunoglobulin E (IgE) levels were significantly lower in the unheated yuzu seed oil group. Oral ingestion of yuzu seed oil in NC/Nga AD model mice significantly suppressed dermatitis deterioration and decreased serum IgE levels. Clinical trials (n = 41) have already confirmed that unheated yuzu oil is safe for long-term intake, further suggesting its potential use in improving AD symptoms. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Development of the Japanese Economy and Globalization of Corporations: Taking Mitsui & Co., Ltd. as an Example

Author

NISHIMURA, Makoto and WATANABE, Yoshiya

Abstract

The Sogoshosha Mitsui & Co., Ltd. was established in national interest following the Meiji Restoration, as a countermeasure against the Gaishos controlling the Japanese trade scene. It played a remarkable role in Japan’s modernization as a “software of the industry”. Mitsui began as a commission merchant and developed further at times as a venture capital, natural resources developer, industrial organizer and overseas project organizer, in answer to the needs of Japan’s modernization. This paper scrutinizes not only Mitsui’s success story but also cases of failure from a macro-economic viewpoint.

Published
2008

14. The Adjuvant Effect of Sophy ¥-Glucan to the Antibody Response in Poultry Immunized by the Avian Influenza A H5N1 and H5N2 Vaccines

Author

Le, Thanh Hoa, primary, Le, Tran Binh, additional, Doan, Thanh Huong Thi, additional, Quyen, Dong Van, additional, Le, Kim Xuyen Thi, additional, Pham, Viet Cuong, additional, Nagataki, Mitsuru, additional, Nomura, Haruka, additional, Ikeue, Yasunori, additional, Watanabe, Yoshiya, additional, and Agatsuma, Takeshi, additional

Published
2011
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25. Differentiation Stages of Eosinophils Characterized by Hyaluronic Acid Binding via CD44 and Responsiveness to Stimuli

Author

Watanabe, Yoshiya, primary, Hashizume, Minoru, additional, Kataoka, Sayo, additional, Hamaguchi, Emi, additional, Morimoto, Norihito, additional, Tsuru, Shinobu, additional, Katoh, Shigeki, additional, Miyake, Kensuke, additional, Matsushima, Kouji, additional, Tominaga, Mari, additional, Kurashige, Takanobu, additional, Fujimoto, Shigeyoshi, additional, Kincade, Paul W., additional, and Tominaga, Akira, additional

Published
2001
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40. Effect of Sophy β-Glucan on Immunity and Growth Performance in Broiler Chicken.

Author

RAJAPAKSE, Jayanthe R. P. V., BUDDHIKA, M. D. P., NAGATAKI, Mitsuru, NOMURA, Haruka, WATANABE, Yoshiya, IKEUE, Yasunori, and AGATSUMA, Takeshi

Subjects
BROILER chickens, IMMUNITY, POULTRY growth, IMMUNOGLOBULINS, GLUCANS, WATER, BODY weight
Abstract

The article presents the results of a study on the influence of Sophy ß-glucan on the growth and immunity development in broiler chicken. According to the authors, broiler chickens treated with one percent of ß-glucan and ad libitum with water resulted an increase in the mean body weight and the mean antibody titres, illustrating the presence of immue stimulating effect of ß-glucan. They add that the immuno-modularity role of ß-glucan in partitioning nutrients towards growth could be the reason for the improved growth of broiler chicken.

Published
2010
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42. Aureobasidium-Derived Soluble Branched (1,3-1,6) α-Glucan (Sophy α-glucan) Enhances Natural Killer Activity in Leishmania amazonensis-Infected Mice.

Author

Yatawara, Lalani, Wickramasinghe, Susiji, Nagataki, Mitsuru, Takamoto, Misa, Nomura, Haruka, Ikeue, Yasunori, Watanabe, Yoshiya, and Agatsum, Takeshi

Subjects
GLUCANS, KILLER cells, INTERFERONS, INTERLEUKIN-4, CELLULAR immunity, LEISHMANIA, LABORATORY mice
Abstract

The β-glucans derived from yeast cell walls have been reported for having many immunomodulatory activities in vivo and in vitro. In this study, Aureobasidium-derived soluble branched (1,3-1,6) β-glucan (Sophy β-glucan) was checked for natural killer (NK) activity and for the production of IFN-γ and IL-4 in Leishmania amazonensis infection. The main experiment was performed with a group of female C57BL/6 and BALB/c mice, orally supplemented with 5% of Sophy β-glucan and infected with promastogotes of L. amazonensis (1 x 107) into the footpad. Increase in the footpad thickness with time was observed in BALB/c mice in spite of the oral Sophy b-glucan supplement, but it was less in C57BL/6 mice. The difference in overall mean footpad thickness between 'infection only' versus 'infection + glucan' groups was statistically significant (P < 0.001). High NK activity in C57BL/6 than BALB/c mice was observed in 'glucan only' group compared to the control group and also in 'infection + glucan' group compared to 'infection only' group. The difference in the NK activity among these groups was significant (P < 0.05). The IFN-γ level increased at weeks 7 and 8 post-infection in C57BL/6 mice and was significantly high in 'infection + glucan' group compared to the 'infection only' group (P < 0.05). IL-4 levels did not increase up to detectable levels throughout the study. The results led a conclusion that Sophy β-glucan enhances NK activity and cellular immunity in L. amazonensis-infected mice. [ABSTRACT FROM AUTHOR]

Published
2009
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43. IL-5–Induced Eosinophils Suppress the Growth of Leishmania amazonensis In Vivo and Kill Promastigotes In Vitro in Response to Either IL-4 or IFN-γ.

Author

Watanabe, Yoshiya, Hamaguchi-Tsuru, Emi, Morimoto, Norihito, Nishio, Youhei, Yagyu, Ken-ichi, Konishi, Yuko, Tominaga, Mari, Miyazaki, Jun-Ichi, Furuya, Masato, and Tominaga, Akira

Subjects
*EOSINOPHILS, *LEISHMANIASIS, *INTERLEUKIN-4, *INTERFERONS, *LEUCOCYTES, *GENETIC mutation, *CANCER cells
Abstract

In IL-5 transgenic mice (C3H/HeN-TgN(IL-5)-Imeg), in which 50% of peripheral blood leukocytes are eosinophils, the development of infection by Leishmania amazonensis was clearly suppressed. To determine mechanistically how this protozoan parasite is killed, we performed in vitro killing experiments. Either IL-4 or IFN-γ effectively stimulated eosinophils to kill Leishmania amazonensis promastigotes, and most of the killing was inhibited by catalase but not by the NO inhibitor L-N5-(1-iminoethyl)-ornithine, suggesting that hydrogen peroxide is responsible for the killing of L. amazonensis by eosinophils. There was no significant degranulation of eosinophils in the culture, because eosinophil peroxidase was not detected in culture supernatants when L. amazonensis promastigotes were killed by activated eosinophils. Such resistance was also observed in BALB/c mice, which are highly susceptible to L. amazonensis. Expression plasmids for IL-4, IL-5, and IFN-γ were transferred into muscle by electroporation in vivo starting 1 week before infection. Expression plasmid for IL-5 was most effective in slowing the development of infection among three expression plasmids. Expression plasmid for IL-4 was slightly effective and that for IFN-γ had no effect on the progress of disease. These results suggest that IL-5 gene transfer into muscle by electroporation is useful as a supplementary protection method against L. amazonensis infection. [ABSTRACT FROM AUTHOR]

Published
2004
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45. Goosecoid suppresses cell growth and enhances neuronal differentiation of PC12 cells

Author

Sawada, Ken, Konishi, Yuko, Tominaga, Mari, Watanabe, Yoshiya, Hirano, Jun, Inoue, Shimpei, Kageyama, Ryoichiro, Blum, Martin, and Tominaga, Akira

Abstract

In all vertebrate species, the homeobox gene goosecoid serves as a marker of the Spemann organizer tissue. One function of the organizer is the induction of neural tissue. To investigate the role of goosecoid in neuronal differentiation of mammalian cells, we have introduced goosecoid into PC12 cells. Expression of goosecoid resulted in reduced cell proliferation and enhanced neurite outgrowth in response to NGF. Expression of goosecoid led to a decrease in the percentage of S-phase cells and to upregulation of the expression of the neuron-specific markers MAP-1b and neurofilament-L. Analysis of goosecoid mutants revealed that these effects were independent of either DNA binding or homodimerization of Goosecoid. Coexpression of the N-terminal portion of the ets transcription factor PU.1, a protein that can bind to Goosecoid, repressed neurite outgrowth and rescued the proliferation of PC12 cultures. In contrast, expression of the bHLH transcription factor HES-1 repressed goosecoid- mediated neurite outgrowth without changing the proportion of S-phase cells. These results suggest that goosecoid is involved in neuronal differentiation in two ways, by slowing the cell cycle and stimulating neurite outgrowth, and that these two events are separately regulated.

Published
2000
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50. RADIOISOTOPES

Author

TABUSHI, Katsuyoshi, primary, ITOH, Susumu, additional, WATANABE, Yoshiya, additional, HARADA, Akio, additional, NAKAJIMA, Tetsuo, additional, YAMAKAWA, Michitaka, additional, SAKURA, Mizuyoshi, additional, AKIYAMA, Yoshihisa, additional, SASAKI, Yasuhito, additional, and NAGAI, Teruo, additional

Published
1981
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