Search

Your search keyword '"Watanabe, Hirohisa"' showing total 822 results
Start Over Author "Watanabe, Hirohisa"
822 results on '"Watanabe, Hirohisa"'

1. Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study

Author

Sakurai, Keita, Tokumaru, Aya M., Yoshida, Mari, Saito, Yuko, Wakabayashi, Koichi, Komori, Takashi, Hasegawa, Masato, Ikeuchi, Takeshi, Hayashi, Yuichi, Shimohata, Takayoshi, Murayama, Shigeo, Iwasaki, Yasushi, Uchihara, Toshiki, Sakai, Motoko, Yabe, Ichiro, Tanikawa, Satoshi, Takigawa, Hiroshi, Adachi, Tadashi, Hanajima, Ritsuko, Fujimura, Harutoshi, Hayashi, Kentaro, Sugaya, Keizo, Hasegawa, Kazuko, Sano, Terunori, Takao, Masaki, Yokota, Osamu, Miki, Tomoko, Kobayashi, Michio, Arai, Nobutaka, Ohkubo, Takuya, Yokota, Takanori, Mori, Keiko, Ito, Masumi, Ishida, Chiho, Idezuka, Jiro, Toyoshima, Yasuko, Kanazawa, Masato, Aoki, Masashi, Hasegawa, Takafumi, Watanabe, Hirohisa, Hashizume, Atsushi, Niwa, Hisayoshi, Yasui, Keizo, Ito, Keita, Washimi, Yukihiko, Kubota, Akatsuki, Toda, Tatsushi, Nakashima, Kenji, and Aiba, Ikuko

Published
2024
Full Text
View/download PDF

4. A Low-Cost Neural ODE with Depthwise Separable Convolution for Edge Domain Adaptation on FPGAs

Author

Kawakami, Hiroki, Watanabe, Hirohisa, Sugiura, Keisuke, and Matsutani, Hiroki

Subjects
Computer Science - Machine Learning, Computer Science - Hardware Architecture
Abstract

High-performance deep neural network (DNN)-based systems are in high demand in edge environments. Due to its high computational complexity, it is challenging to deploy DNNs on edge devices with strict limitations on computational resources. In this paper, we derive a compact while highly-accurate DNN model, termed dsODENet, by combining recently-proposed parameter reduction techniques: Neural ODE (Ordinary Differential Equation) and DSC (Depthwise Separable Convolution). Neural ODE exploits a similarity between ResNet and ODE, and shares most of weight parameters among multiple layers, which greatly reduces the memory consumption. We apply dsODENet to a domain adaptation as a practical use case with image classification datasets. We also propose a resource-efficient FPGA-based design for dsODENet, where all the parameters and feature maps except for pre- and post-processing layers can be mapped onto on-chip memories. It is implemented on Xilinx ZCU104 board and evaluated in terms of domain adaptation accuracy, inference speed, FPGA resource utilization, and speedup rate compared to a software counterpart. The results demonstrate that dsODENet achieves comparable or slightly better domain adaptation accuracy compared to our baseline Neural ODE implementation, while the total parameter size without pre- and post-processing layers is reduced by 54.2% to 79.8%. Our FPGA implementation accelerates the inference speed by 23.8 times.

Published
2021
Full Text
View/download PDF

5. Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B

Author

Tada, Tomohiro, Hara, Kazuhiro, Fujita, Naotoshi, Ito, Yoshinori, Yamaguchi, Hiroshi, Ohdake, Reiko, Kawabata, Kazuya, Ogura, Aya, Kato, Toshiyasu, Yokoi, Takamasa, Masuda, Michihito, Abe, Shinji, Miyao, Shinichi, Naganawa, Shinji, Katsuno, Masahisa, Watanabe, Hirohisa, Sobue, Gen, and Kato, Katsuhiko

Published
2023
Full Text
View/download PDF

9. Accelerating ODE-Based Neural Networks on Low-Cost FPGAs

Author

Watanabe, Hirohisa and Matsutani, Hiroki

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

ODENet is a deep neural network architecture in which a stacking structure of ResNet is implemented with an ordinary differential equation (ODE) solver. It can reduce the number of parameters and strike a balance between accuracy and performance by selecting a proper solver. It is also possible to improve the accuracy while keeping the same number of parameters on resource-limited edge devices. In this paper, using Euler method as an ODE solver, a part of ODENet is implemented as a dedicated logic on a low-cost FPGA (Field-Programmable Gate Array) board, such as PYNQ-Z2 board. As ODENet variants, reduced ODENets (rODENets) each of which heavily uses a part of ODENet layers and reduces/eliminates some layers differently are proposed and analyzed for low-cost FPGA implementation. They are evaluated in terms of parameter size, accuracy, execution time, and resource utilization on the FPGA. The results show that an overall execution time of an rODENet variant is improved by up to 2.66 times compared to a pure software execution while keeping a comparable accuracy to the original ODENet., Comment: RAW'21

Published
2020

10. An FPGA-Based On-Device Reinforcement Learning Approach using Online Sequential Learning

Author

Watanabe, Hirohisa, Tsukada, Mineto, and Matsutani, Hiroki

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

DQN (Deep Q-Network) is a method to perform Q-learning for reinforcement learning using deep neural networks. DQNs require a large buffer and batch processing for an experience replay and rely on a backpropagation based iterative optimization, making them difficult to be implemented on resource-limited edge devices. In this paper, we propose a lightweight on-device reinforcement learning approach for low-cost FPGA devices. It exploits a recently proposed neural-network based on-device learning approach that does not rely on the backpropagation method but uses OS-ELM (Online Sequential Extreme Learning Machine) based training algorithm. In addition, we propose a combination of L2 regularization and spectral normalization for the on-device reinforcement learning so that output values of the neural network can be fit into a certain range and the reinforcement learning becomes stable. The proposed reinforcement learning approach is designed for PYNQ-Z1 board as a low-cost FPGA platform. The evaluation results using OpenAI Gym demonstrate that the proposed algorithm and its FPGA implementation complete a CartPole-v0 task 29.77x and 89.40x faster than a conventional DQN-based approach when the number of hidden-layer nodes is 64., Comment: RAW'21

Published
2020

13. Cabergoline in the Treatment of Parkinson’s Disease

Author

Tsuboi, Takashi, Watanabe, Hirohisa, Katsuno, Masahisa, Sobue, Gen, Nagatsu, Toshiharu, Section editor, Nakashima, Akira, Section editor, Riederer, Peter, editor, Laux, Gerd, editor, Nagatsu, Toshiharu, editor, Le, Weidong, editor, and Riederer, Christian, editor

Published
2022
Full Text
View/download PDF

14. Pergolide in the Treatment of Parkinson’s Disease

Author

Tsuboi, Takashi, Watanabe, Hirohisa, Katsuno, Masahisa, Sobue, Gen, Nagatsu, Toshiharu, Section editor, Nakashima, Akira, Section editor, Riederer, Peter, editor, Laux, Gerd, editor, Nagatsu, Toshiharu, editor, Le, Weidong, editor, and Riederer, Christian, editor

Published
2022
Full Text
View/download PDF

16. Stress-impaired reward pathway promotes distinct feeding behavior patterns

Author

Fujioka, Yusuke, primary, Kawai, Kaori, additional, Endo, Kuniyuki, additional, Ishibashi, Minaka, additional, Iwade, Nobuyuki, additional, Tuerde, Dilina, additional, Kaibuchi, Kozo, additional, Yamashita, Takayuki, additional, Yamanaka, Akihiro, additional, Katsuno, Masahisa, additional, Watanabe, Hirohisa, additional, Sobue, Gen, additional, and Ishigaki, Shinsuke, additional

Published
2024
Full Text
View/download PDF

17. Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study

Author

Nishikawa, Noriko, Murata, Miho, Hatano, Taku, Mukai, Yohei, Saitoh, Yuji, Sakamoto, Takashi, Hanakawa, Takashi, Kamei, Yuichi, Tachimori, Hisateru, Hatano, Kenji, Matsuda, Hiroshi, Taruno, Yosuke, Sawamoto, Nobukatsu, Kajiyama, Yuta, Ikenaka, Kensuke, Kawabata, Kazuya, Nakamura, Tomohiko, Iwaki, Hirotaka, Kadotani, Hiroshi, Sumi, Yukiyoshi, Inoue, Yuichi, Hayashi, Toshihiro, Ikeuchi, Takeshi, Shimo, Yasushi, Mochizuki, Hideki, Watanabe, Hirohisa, Hattori, Nobutaka, Takahashi, Yuji, and Takahashi, Ryosuke

Published
2022
Full Text
View/download PDF

18. Functional connector hubs in the cerebellum

Author

Kawabata, Kazuya, Bagarinao, Epifanio, Watanabe, Hirohisa, Maesawa, Satoshi, Mori, Daisuke, Hara, Kazuhiro, Ohdake, Reiko, Masuda, Michihito, Ogura, Aya, Kato, Toshiyasu, Koyama, Shuji, Katsuno, Masahisa, Wakabayashi, Toshihiko, Kuzuya, Masafumi, Hoshiyama, Minoru, Isoda, Haruo, Naganawa, Shinji, Ozaki, Norio, and Sobue, Gen

Published
2022
Full Text
View/download PDF

19. Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis

Author

Tohnai, Genki, Nakamura, Ryoichi, Atsuta, Naoki, Nakatochi, Masahiro, Hayashi, Naoki, Ito, Daisuke, Watanabe, Hazuki, Watanabe, Hirohisa, Katsuno, Masahisa, Izumi, Yuishin, Taniguchi, Akira, Kanai, Kazuaki, Morita, Mitsuya, Kano, Osamu, Kuwabara, Satoshi, Oda, Masaya, Abe, Koji, Aoki, Masashi, Aiba, Ikuko, Okamoto, Koichi, Mizoguchi, Kouichi, Ishihara, Tomohiko, Kawata, Akihiro, Yokota, Takanori, Hasegawa, Kazuko, Nagano, Isao, Yabe, Ichiro, Tanaka, Fumiaki, Kuru, Satoshi, Hattori, Nobutaka, Nakashima, Kenji, Kaji, Ryuji, and Sobue, Gen

Published
2022
Full Text
View/download PDF

22. Pramipexole Hyperactivates the External Globus Pallidus and Impairs Decision-Making in a Mouse Model of Parkinson's Disease.

Author

Kubota, Hisayoshi, Zhou, Xinzhu, Zhang, Xinjian, Watanabe, Hirohisa, and Nagai, Taku

Subjects
IMPULSE control disorders, COMPULSIVE gambling, PARKINSON'S disease, DOPAMINE agonists, GLOBUS pallidus, DOPAMINE receptors
Abstract

In patients with Parkinson's disease (PD), dopamine replacement therapy with dopamine D2/D3 receptor agonists induces impairments in decision-making, including pathological gambling. The neurobiological mechanisms underlying these adverse effects remain elusive. Here, in a mouse model of PD, we investigated the effects of the dopamine D3 receptor (D3R)-preferring agonist pramipexole (PPX) on decision-making. PD model mice were generated using a bilateral injection of the toxin 6-hydroxydopamine into the dorsolateral striatum. Subsequent treatment with PPX increased disadvantageous choices characterized by a high-risk/high-reward in the touchscreen-based Iowa Gambling Task. This effect was blocked by treatment with the selective D3R antagonist PG-01037. In model mice treated with PPX, the number of c-Fos-positive cells was increased in the external globus pallidus (GPe), indicating dysregulation of the indirect pathway in the corticothalamic-basal ganglia circuitry. In accordance, chemogenetic inhibition of the GPe restored normal c-Fos activation and rescued PPX-induced disadvantageous choices. These findings demonstrate that the hyperactivation of GPe neurons in the indirect pathway impairs decision-making in PD model mice. The results provide a candidate mechanism and therapeutic target for pathological gambling observed during D2/D3 receptor pharmacotherapy in PD patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

23. Elevated cerebrospinal fluid IgG index in herpes simplex encephalitis post‐HSV‐1 clearance: A preliminary study.

Author

Asakura, Mao, Mizutani, Yasuaki, Shima, Sayuri, Kawamura, Yoshiki, Ueda, Akihiro, Ito, Mizuki, Mutoh, Tatsuro, Yoshikawa, Tetsushi, and Watanabe, Hirohisa

Subjects
HUMAN herpesvirus 1, HERPES simplex, HERPES simplex virus, CEREBROSPINAL fluid, IMMUNOGLOBULIN G, CHICKENPOX
Abstract

Herpes simplex encephalitis (HSE) is an acute form of encephalitis that can lead to poor neurological outcomes. Although the exact pathogenesis of HSE remains elusive, recent reports suggest a significant role for postinfectious immune‐inflammatory processes in the central nervous system (CNS). This study aimed to clarify the association between CNS autoimmune responses and clinical presentation in patients with HSE, focusing on cerebrospinal fluid (CSF) characteristics, particularly the IgG index. We retrospectively analyzed 176 consecutive patients suspected of having aseptic meningitis /encephalitis for chronological changes in CSF findings and clinical presentations. These patients underwent PCR screening for herpesviruses (HV) in their CSF. We identified seven patients positive for herpes simplex virus type 1 (HSV‐1), 20 patients positive for varicella‐zoster virus, and 17 patients who met the criteria for aseptic meningitis but were PCR‐negative for HV. Patients in the HSV‐1‐positive group exhibited a significant increase in the IgG index at the time of PCR‐negative conversion compared with on admission (p = 0.0156), while such a change was not observed in the other two groups. Additionally, all patients in the HSV‐1‐positive group tested negative for anti‐neural autoantibodies in CSF and serum samples collected approximately 3 weeks after onset. This study, therefore, highlights that CSF IgG index elevation occurs even after PCR‐confirmed HSV‐1 clearance, which might indicate immunopathogenesis that is independent of antibody‐mediated mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

26. Effect of levodopa on pathological gait in Dravet syndrome: A randomized crossover trial using three‐dimensional gait analysis

Author

Suzuki, Takeshi, primary, Natsume, Jun, additional, Ito, Yuji, additional, Ito, Tadashi, additional, Noritake, Koji, additional, Kinoshita, Fumie, additional, Fukasawa, Tatsuya, additional, Tsuji, Takeshi, additional, Itomi, Kazuya, additional, Kurahashi, Hirokazu, additional, Kubota, Kazuo, additional, Okanishi, Tohru, additional, Saitoh, Shinji, additional, Sugiura, Hideshi, additional, Watanabe, Hirohisa, additional, Takahashi, Yoshiyuki, additional, and Kidokoro, Hiroyuki, additional

Published
2024
Full Text
View/download PDF

29. Genome-wide association analysis identifies PLA2G4C as a susceptibility locus for Multiple System Atrophy

Author

Tsuji, Shoji, primary, Nakahara, Yasuo, additional, Mitsui, Jun, additional, Date, Hidetoshi, additional, Porto, Kristine Joyce, additional, Hyashi, Yasuhiro, additional, Yamashita, Atsushi, additional, Kusakabe, Yoshio, additional, Matsukawa, Takashi, additional, Ishiura, Hiroyuki, additional, Yasuda, Tsutomu, additional, Iwata, Atsushi, additional, Goto, Jun, additional, Ichikawa, Yaeko, additional, Momose, Yoshio, additional, Takahashi, Yuji, additional, Toda, Tatsushi, additional, Ohta, Rikifumi, additional, Yoshimura, Jun, additional, Morishita, Shinichi, additional, Gustavsson, Emil, additional, Christy, Darren, additional, Maczis, Melisa, additional, Kim, Han-Joon, additional, Park, Sung-Sup, additional, Zhang, Jin, additional, Gu, Weihong, additional, Scholz, Sonja, additional, Chelban, Viorica, additional, Mok, Kin, additional, Houlden, Henry, additional, Yabe, Ichiro, additional, Sasaki, Hidenao, additional, Matsushima, Masaaki, additional, Takashima, Hiroshi, additional, Kikuchi, Akio, additional, Aoki, Masashi, additional, Hara, Kenju, additional, Kakita, Akiyoshi, additional, Yamada, Mitsunori, additional, Takahashi, Hitoshi, additional, Onodera, Osamu, additional, Nishizawa, Masatoyo, additional, Watanabe, Hirohisa, additional, Ito, Mizuki, additional, Sobue, Gen, additional, Ishikawa, Kinya, additional, Mizusawa, Hidehiro, additional, Kanai, Kazuaki, additional, Kuwabara, Satoshi, additional, Arai, Kimihito, additional, Koyano, Shigeru, additional, Kuroiwa, Yoshiyuki, additional, Hasegawa, Kazuko, additional, Yuasa, Tatsuhiko, additional, Yasui, Kenichi, additional, Nakashima, Kenji, additional, Ito, Hijiri, additional, Izumi, Yuishin, additional, Kaji, Ryuji, additional, kato, Takeo, additional, Kusunoki, Susumu, additional, Osaki, Yasushi, additional, Horiuchi, Masahiro, additional, Yamamoto, Ken, additional, Shimada, Mihoko, additional, Miyagawa, Taku, additional, Kawai, Yosuke, additional, Nishida, Nao, additional, Tokunaga, Katsushi, additional, Durr, Alexandra, additional, Brice, Alexis, additional, Filla, Alessandro, additional, Klockgether, Thomas, additional, Wuellner, Ullrich, additional, Tanner, Caroline, additional, Kukull, Walter, additional, Lee, Virginia, additional, Masliah, Eliezer, additional, Low, Phillip, additional, Sandroni, Paola, additional, Ozelius, Laurie, additional, Foroud, Tatiana, additional, Farrer, Matthew, additional, and Trojanowski, John, additional

Published
2024
Full Text
View/download PDF

36. Tau Accumulation and Network Breakdown in Alzheimer’s Disease

Author

Watanabe, Hirohisa, Bagarinao, Epifanio, Yokoi, Takamasa, Yamaguchi, Hiroshi, Ishigaki, Shinsuke, Mausuda, Michihito, Katsuno, Masahisa, Sobue, Gen, Crusio, Wim E., Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Takashima, Akihiko, editor, Wolozin, Benjamin, editor, and Buee, Luc, editor

Published
2019
Full Text
View/download PDF

45. Correlations between serotonin impairments and clinical indices in multiple system atrophy.

Author

Nagao, Ryunosuke, Mizutani, Yasuaki, Shima, Sayuri, Ueda, Akihiro, Ito, Mizuki, Yoshimoto, Junichiro, and Watanabe, Hirohisa

Subjects
DIASTOLIC blood pressure, SEROTONIN syndrome, SEROTONIN, SYSTOLIC blood pressure, HIGH performance liquid chromatography, STRUCTURAL equation modeling, MULTIPLE system atrophy
Abstract

Background and purpose: Multiple system atrophy (MSA) is a neurodegenerative disease with characteristic motor and autonomic symptoms. Impaired brain serotonergic innervation can be associated with various clinical indices of MSA; however, the relationship between clinical symptoms and cerebrospinal fluid (CSF) levels of 5‐hydroxyindole acetic acid (5‐HIAA), a main serotonin metabolite, has not been fully elucidated. Methods: To compare CSF 5‐HIAA levels between patients with MSA and healthy controls, we included 33 controls and 69 MSA patients with either predominant parkinsonian or cerebellar ataxia subtypes. CSF 5‐HIAA levels were measured using high‐performance liquid chromatography. Additionally, we investigated correlations between CSF 5‐HIAA and various clinical indices in 34 MSA patients. Results: CSF 5‐HIAA levels were significantly lower in MSA patients than in controls (p < 0.0001). Probable MSA patients had lower CSF 5‐HIAA levels than possible MSA patients (p < 0.001). In MSA patients, CSF 5‐HIAA levels were inversely correlated with scores in Parts 1, 2, and 4 of the Unified Multiple System Atrophy Rating Scale, and with systolic and diastolic blood pressure in Part 3. Structural equation modeling revealed significant paths between serotonin and clinical symptoms, and significance was highest for activities of daily living, walking, and body sway. Conclusions: Serotonin dysfunction, as assessed by CSF 5‐HIAA levels, may implicate greater MSA severity. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. Granuloma, vasculitis, and demyelination in sarcoid neuropathy

Author

Mouri, Naohiro, primary, Koike, Haruki, additional, Fukami, Yuki, additional, Takahashi, Mie, additional, Yagi, Satoru, additional, Furukawa, Soma, additional, Suzuki, Masashi, additional, Kishimoto, Yoshiyuki, additional, Murate, Kenichiro, additional, Nukui, Takamasa, additional, Yoshida, Tamaki, additional, Kudo, Yosuke, additional, Tada, Mikiko, additional, Higashiyama, Yuichi, additional, Watanabe, Hirohisa, additional, Nakatsuji, Yuji, additional, Tanaka, Fumiaki, additional, and Katsuno, Masahisa, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results