Search

Your search keyword '"Watabe, Taro"' showing total 20 results
Start Over Author "Watabe, Taro"
20 results on '"Watabe, Taro"'

3. Prognostic significance of C‐reactive protein in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab.

Author

Kaneko, Shun, Asahina, Yasuhiro, Murakawa, Miyako, Ueyama, Shunsuke, Maeyashiki, Chiaki, Watanabe, Hideki, Kusano‐Kitazume, Akiko, Sato, Ayako, Uchidate, Kozue, Asakawa, Takehito, Watanabe, Sho, Iizuka, Yasuhiro, Shibata, Isamu, Oooka, Shinya, Karakama, Yuko, Fujii, Takashi, Watabe, Taro, Akahoshi, Keiichi, Tanabe, Minoru, and Inada, Kento

Subjects
C-reactive protein, ALPHA fetoproteins, RECEIVER operating characteristic curves, ATEZOLIZUMAB, BEVACIZUMAB, HEPATOCELLULAR carcinoma
Abstract

Aim: C‐reactive protein (CRP) is both an inflammatory and prognostic marker in various cancers. This study aimed to elucidate the characteristics of CRP and the prognostic factors in patients who were administered with atezolizumab plus bevacizumab (ATZ + BEV) for unresectable hepatocellular carcinoma (HCC). Methods: A total of 213 patients who received ATZ + BEV for HCC from November 2020 to March 2023 at 15 hospitals were enrolled in this retrospective study. The prognosis was analyzed by subdividing the patients based on baseline characteristics, radiologic response, and treatment lines. Accuracy of survival prediction was assessed using CRP, alpha fetoprotein (AFP), C‐reactive protein and alpha fetoprotein in immunotherapy (CRAFITY), and Glasgow Prognostic Score. Results: Compared with patients with baseline CRP <1 mg/dL, those with baseline CRP ≥1 mg/dL (n = 45) had a significantly higher baseline albumin–bilirubin score and AFP levels, significantly lower disease control rate (62.2%), and significantly shorter median overall survival (hazards ratios 2.292; 95% confidence interval 1.313–5.107; log‐rank test, p < 0.001). Multivariate analysis identified CRP ≥1 mg/dL, AFP ≥100 ng/mL, and modified albumin–bilirubin grade as the significant prognostic factors. The baseline CRP, AFP, CRAFITY, and Glasgow Prognostic Score demonstrated higher discrimination for 1‐year survival prediction after first‐line ATZ + BEV administration, compared with beyond second line, with area under the receiver operating characteristic curves of 0.759, 0.761, 0.805, and 0.717, respectively. Conclusions: CRP was a significant biomarker in patients treated with ATZ + BEV for HCC. Elevated CRP levels may indicate aggressive cancer progression and potential resistance to ATZ + BEV therapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Apelin expression is downregulated in T cells in a murine model of chronic colitis

Author

Yamada, Daiki, primary, Kojima, Yudai, additional, Hosoya, Akinori, additional, Suzuki, Masahiro, additional, Watabe, Taro, additional, Inoue, Tadahiko, additional, Tsugawa, Naoya, additional, Asakawa, Takehito, additional, Yonemoto, Yuki, additional, Onizawa, Michio, additional, Nemoto, Yasuhiro, additional, Oshima, Shigeru, additional, Shimonaka, Motoyuki, additional, Kuba, Keiji, additional, Ishida, Junji, additional, Fukamizu, Akiyoshi, additional, Penninger, Josef M., additional, Watanabe, Mamoru, additional, Okamoto, Ryuichi, additional, and Nagaishi, Takashi, additional

Published
2023
Full Text
View/download PDF

6. Corrigendum to “CEACAM1 specifically suppresses B cell receptor signaling-mediated activation”

Author

Tsugawa, Naoya, primary, Yamada, Daiki, additional, Watabe, Taro, additional, Onizawa, Michio, additional, Wang, Shuang, additional, Nemoto, Yasuhiro, additional, Oshima, Shigeru, additional, Tsubata, Takeshi, additional, Adachi, Takahiro, additional, Kawano, Yohei, additional, Watanabe, Mamoru, additional, Blumberg, Richard S., additional, Okamoto, Ryuichi, additional, and Nagaishi, Takashi, additional

Published
2021
Full Text
View/download PDF

7. Immunoglobulin A–specific deficiency induces spontaneous inflammation specifically in the ileum

Author

Nagaishi, Takashi, primary, Watabe, Taro, additional, Kotake, Kunihiko, additional, Kumazawa, Toshihiko, additional, Aida, Tomomi, additional, Tanaka, Kohichi, additional, Ono, Ryuichi, additional, Ishino, Fumitoshi, additional, Usami, Takako, additional, Miura, Takamasa, additional, Hirakata, Satomi, additional, Kawasaki, Hiroko, additional, Tsugawa, Naoya, additional, Yamada, Daiki, additional, Hirayama, Kazuhiro, additional, Yoshikawa, Soichiro, additional, Karasuyama, Hajime, additional, Okamoto, Ryuichi, additional, Watanabe, Mamoru, additional, Blumberg, Richard S, additional, and Adachi, Takahiro, additional

Published
2021
Full Text
View/download PDF

9. Immunoglobulin A–specific deficiency induces spontaneous inflammation specifically in the ileum

Author

Nagaishi, Takashi, Watabe, Taro, Kotake, Kunihiko, Kumazawa, Toshihiko, Aida, Tomomi, Tanaka, Kohichi, Ono, Ryuichi, Ishino, Fumitoshi, Usami, Takako, Miura, Takamasa, Hirakata, Satomi, Kawasaki, Hiroko, Tsugawa, Naoya, Yamada, Daiki, Hirayama, Kazuhiro, Yoshikawa, Soichiro, Karasuyama, Hajime, Okamoto, Ryuichi, Watanabe, Mamoru, Blumberg, Richard S, and Adachi, Takahiro

Abstract

ObjectiveAlthough immunoglobulin A (IgA) is abundantly expressed in the gut and known to be an important component of mucosal barriers against luminal pathogens, its precise function remains unclear. Therefore, we tried to elucidate the effect of IgA on gut homeostasis maintenance and its mechanism.DesignWe generated various IgA mutant mouse lines using the CRISPR/Cas9 genome editing system. Then, we evaluated the effect on the small intestinal homeostasis, pathology, intestinal microbiota, cytokine production, and immune cell activation using intravital imaging.ResultsWe obtained two lines, with one that contained a <50 base pair deletion in the cytoplasmic region of the IgA allele (IgA tail-mutant; IgAtm/tm) and the other that lacked the most constant region of the IgH α chain, which resulted in the deficiency of IgA production (IgA−/−). IgA−/−exhibited spontaneous inflammation in the ileum but not the other parts of the gastrointestinal tract. Associated with this, there were significantly increased lamina propria CD4+T cells, elevated productions of IFN-γ and IL-17, increased ileal segmented filamentous bacteria and skewed intestinal microflora composition. Intravital imaging using Ca2+biosensor showed that IgA−/−had elevated Ca2+signalling in Peyer’s patch B cells. On the other hand, IgAtm/tmseemed to be normal, suggesting that the IgA cytoplasmic tail is dispensable for the prevention of the intestinal disorder.ConclusionIgA plays an important role in the mucosal homeostasis associated with the regulation of intestinal microbiota and protection against mucosal inflammation especially in the ileum.

Published
2022
Full Text
View/download PDF

18. Myosin Light Chain Kinase Expression Induced via Tumor Necrosis Factor Receptor 2 Signaling in the Epithelial Cells Regulates the Development of Colitis-Associated Carcinogenesis

Author

Suzuki, Masahiro, primary, Nagaishi, Takashi, additional, Yamazaki, Motomi, additional, Onizawa, Michio, additional, Watabe, Taro, additional, Sakamaki, Yuriko, additional, Ichinose, Shizuko, additional, Totsuka, Mamoru, additional, Oshima, Shigeru, additional, Okamoto, Ryuichi, additional, Shimonaka, Motoyuki, additional, Yagita, Hideo, additional, Nakamura, Tetsuya, additional, and Watanabe, Mamoru, additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results