Author: "Wassink, Thomas H" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Wassink, Thomas H"' showing total 281 results

Start Over Author "Wassink, Thomas H"

281 results on '"Wassink, Thomas H"'

1. Genetic architecture of subcortical brain structures in 38,851 individuals

Author: Satizabal, Claudia L., Adams, Hieab H. H., Hibar, Derrek P., White, Charles C., Knol, Maria J., Stein, Jason L., Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V., Smith, Albert V., Bis, Joshua C., Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J., Yang, Jingyun, Yanek, Lisa R., Lee, Tom V., Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D., Desrivières, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentería, Miguel E., Kim, Sungeun, Hoehn, David, Armstrong, Nicola J., Chen, Qiang, Holmes, Avram J., den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santiañez, Roberto, Kraemer, Bernd, Håberg, Asta K., Jones, Hannah J., Pike, G. Bruce, Stein, Dan J., Stevens, Allison, Bralten, Janita, Vernooij, Meike W., Harris, Tamara B., Filippi, Irina, Witte, A. Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H., Becker, James T., Doan, Nhat Trung, Hagenaars, Saskia P., Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M., Ames, David, Goldman, Aaron L., Lee, Phil H., Boomsma, Dorret I., Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M., Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M., Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E., Shin, Jean, Ipser, Jonathan C., Vinke, Louis N., Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K., Aribisala, Benjamin S., Schmidt, Helena, Strike, Lachlan T., Cheng, Ching-Yu, Risacher, Shannon L., Pütz, Benno, Fleischman, Debra A., Assareh, Amelia A., Mattay, Venkata S., Buckner, Randy L., Mecocci, Patrizia, Dale, Anders M., Cichon, Sven, Boks, Marco P., Matarin, Mar, Penninx, Brenda W. J. H., Calhoun, Vince D., Chakravarty, M. Mallar, Marquand, Andre F., Macare, Christine, Kharabian Masouleh, Shahrzad, Oosterlaan, Jaap, Amouyel, Philippe, Hegenscheid, Katrin, Rotter, Jerome I., Schork, Andrew J., Liewald, David C. M., de Zubicaray, Greig I., Wong, Tien Yin, Shen, Li, Sämann, Philipp G., Brodaty, Henry, Roffman, Joshua L., de Geus, Eco J. C., Tsolaki, Magda, Erk, Susanne, van Eijk, Kristel R., Cavalleri, Gianpiero L., van der Wee, Nic J. A., McIntosh, Andrew M., Gollub, Randy L., Bulayeva, Kazima B., Bernard, Manon, Richards, Jennifer S., Himali, Jayandra J., Loeffler, Markus, Rommelse, Nanda, Hoffmann, Wolfgang, Westlye, Lars T., Valdés Hernández, Maria C., Hansell, Narelle K., van Erp, Theo G. M., Wolf, Christiane, Kwok, John B. J., Vellas, Bruno, Heinz, Andreas, Olde Loohuis, Loes M., Delanty, Norman, Ho, Beng-Choon, Ching, Christopher R. K., Shumskaya, Elena, Singh, Baljeet, Hofman, Albert, van der Meer, Dennis, Homuth, Georg, Psaty, Bruce M., Bastin, Mark E., Montgomery, Grant W., Foroud, Tatiana M., Reppermund, Simone, Hottenga, Jouke-Jan, Simmons, Andrew, Meyer-Lindenberg, Andreas, Cahn, Wiepke, Whelan, Christopher D., van Donkelaar, Marjolein M. J., Yang, Qiong, Hosten, Norbert, Green, Robert C, Thalamuthu, Anbupalam, Mohnke, Sebastian, Hulshoff Pol, Hilleke E., Lin, Honghuang, Jack, Jr, Clifford R., Schofield, Peter R., Mühleisen, Thomas W., Maillard, Pauline, Potkin, Steven G., Wen, Wei, Fletcher, Evan, Toga, Arthur W., Gruber, Oliver, Huentelman, Matthew, Davey Smith, George, Launer, Lenore J., Nyberg, Lars, Jönsson, Erik G., Crespo-Facorro, Benedicto, Koen, Nastassja, Greve, Douglas N., Uitterlinden, André G., Weinberger, Daniel R., Steen, Vidar M., Fedko, Iryna O., Groenewold, Nynke A., Niessen, Wiro J., Toro, Roberto, Tzourio, Christophe, Longstreth, Jr, William T., Ikram, M. Kamran, Smoller, Jordan W., van Tol, Marie-Jose, Sussmann, Jessika E., Paus, Tomas, Lemaître, Hervé, Schroeter, Matthias L., Mazoyer, Bernard, Andreassen, Ole A., Holsboer, Florian, Depondt, Chantal, Veltman, Dick J., Turner, Jessica A., Pausova, Zdenka, Schumann, Gunter, van Rooij, Daan, Djurovic, Srdjan, Deary, Ian J., McMahon, Katie L., Müller-Myhsok, Bertram, Brouwer, Rachel M., Soininen, Hilkka, Pandolfo, Massimo, Wassink, Thomas H., Cheung, Joshua W., Wolfers, Thomas, Martinot, Jean-Luc, Zwiers, Marcel P., Nauck, Matthias, Melle, Ingrid, Martin, Nicholas G., Kanai, Ryota, Westman, Eric, Kahn, René S., Sisodiya, Sanjay M., White, Tonya, Saremi, Arvin, van Bokhoven, Hans, Brunner, Han G., Völzke, Henry, Wright, Margaret J., van ‘t Ent, Dennis, Nöthen, Markus M., Ophoff, Roel A., Buitelaar, Jan K., Fernández, Guillén, Sachdev, Perminder S., Rietschel, Marcella, van Haren, Neeltje E. M., Fisher, Simon E., Beiser, Alexa S., Francks, Clyde, Saykin, Andrew J., Mather, Karen A., Romanczuk-Seiferth, Nina, Hartman, Catharina A., DeStefano, Anita L., Heslenfeld, Dirk J., Weiner, Michael W., Walter, Henrik, Hoekstra, Pieter J., Nyquist, Paul A., Franke, Barbara, Bennett, David A., Grabe, Hans J., Johnson, Andrew D., Chen, Christopher, van Duijn, Cornelia M., Lopez, Oscar L., Fornage, Myriam, Wardlaw, Joanna M., Schmidt, Reinhold, DeCarli, Charles, De Jager, Philip L., Villringer, Arno, Debette, Stéphanie, Gudnason, Vilmundur, Medland, Sarah E., Shulman, Joshua M., Thompson, Paul M., Seshadri, Sudha, and Ikram, M. Arfan
Published: 2019
Full Text: View/download PDF

2. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder

Author: Casey, Jillian P, Magalhaes, Tiago, Conroy, Judith M, Regan, Regina, Shah, Naisha, Anney, Richard, Shields, Denis C, Abrahams, Brett S, Almeida, Joana, Bacchelli, Elena, Bailey, Anthony J, Baird, Gillian, Battaglia, Agatino, Berney, Tom, Bolshakova, Nadia, Bolton, Patrick F, Bourgeron, Thomas, Brennan, Sean, Cali, Phil, Correia, Catarina, Corsello, Christina, Coutanche, Marc, Dawson, Geraldine, de Jonge, Maretha, Delorme, Richard, Duketis, Eftichia, Duque, Frederico, Estes, Annette, Farrar, Penny, Fernandez, Bridget A, Folstein, Susan E, Foley, Suzanne, Fombonne, Eric, Freitag, Christine M, Gilbert, John, Gillberg, Christopher, Glessner, Joseph T, Green, Jonathan, Guter, Stephen J, Hakonarson, Hakon, Holt, Richard, Hughes, Gillian, Hus, Vanessa, Igliozzi, Roberta, Kim, Cecilia, Klauck, Sabine M, Kolevzon, Alexander, Lamb, Janine A, Leboyer, Marion, Le Couteur, Ann, Leventhal, Bennett L, Lord, Catherine, Lund, Sabata C, Maestrini, Elena, Mantoulan, Carine, Marshall, Christian R, McConachie, Helen, McDougle, Christopher J, McGrath, Jane, McMahon, William M, Merikangas, Alison, Miller, Judith, Minopoli, Fiorella, Mirza, Ghazala K, Munson, Jeff, Nelson, Stanley F, Nygren, Gudrun, Oliveira, Guiomar, Pagnamenta, Alistair T, Papanikolaou, Katerina, Parr, Jeremy R, Parrini, Barbara, Pickles, Andrew, Pinto, Dalila, Piven, Joseph, Posey, David J, Poustka, Annemarie, Poustka, Fritz, Ragoussis, Jiannis, Roge, Bernadette, Rutter, Michael L, Sequeira, Ana F, Soorya, Latha, Sousa, Inês, Sykes, Nuala, Stoppioni, Vera, Tancredi, Raffaella, Tauber, Maïté, Thompson, Ann P, Thomson, Susanne, Tsiantis, John, Van Engeland, Herman, Vincent, John B, Volkmar, Fred, Vorstman, Jacob AS, Wallace, Simon, Wang, Kai, Wassink, Thomas H, White, Kathy, and Wing, Kirsty
Subjects: Autism, Genetics, Mental Health, Intellectual and Developmental Disabilities (IDD), Brain Disorders, Biotechnology, Pediatric, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adult, Child, Child Development Disorders, Pervasive, Cluster Analysis, Cohort Studies, DNA Copy Number Variations, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Haplotypes, Homozygote, Humans, Linkage Disequilibrium, Male, Middle Aged, Nuclear Family, Polymorphism, Single Nucleotide, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity
Abstract: Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particular copy number variation, may account for a significant proportion of the genetic basis of ASD. We present a large scale analysis to identify candidate genes which may contain low-frequency recessive variation contributing to ASD while taking into account the potential contribution of population differences to the genetic heterogeneity of ASD. Our strategy, homozygous haplotype (HH) mapping, aims to detect homozygous segments of identical haplotype structure that are shared at a higher frequency amongst ASD patients compared to parental controls. The analysis was performed on 1,402 Autism Genome Project trios genotyped for 1 million single nucleotide polymorphisms (SNPs). We identified 25 known and 1,218 novel ASD candidate genes in the discovery analysis including CADM2, ABHD14A, CHRFAM7A, GRIK2, GRM3, EPHA3, FGF10, KCND2, PDZK1, IMMP2L and FOXP2. Furthermore, 10 of the previously reported ASD genes and 300 of the novel candidates identified in the discovery analysis were replicated in an independent sample of 1,182 trios. Our results demonstrate that regions of HH are significantly enriched for previously reported ASD candidate genes and the observed association is independent of gene size (odds ratio 2.10). Our findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.
Published: 2012

3. Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.

Author: Bucan, Maja, Abrahams, Brett S, Wang, Kai, Glessner, Joseph T, Herman, Edward I, Sonnenblick, Lisa I, Alvarez Retuerto, Ana I, Imielinski, Marcin, Hadley, Dexter, Bradfield, Jonathan P, Kim, Cecilia, Gidaya, Nicole B, Lindquist, Ingrid, Hutman, Ted, Sigman, Marian, Kustanovich, Vlad, Lajonchere, Clara M, Singleton, Andrew, Kim, Junhyong, Wassink, Thomas H, McMahon, William M, Owley, Thomas, Sweeney, John A, Coon, Hilary, Nurnberger, John I, Li, Mingyao, Cantor, Rita M, Minshew, Nancy J, Sutcliffe, James S, Cook, Edwin H, Dawson, Geraldine, Buxbaum, Joseph D, Grant, Struan FA, Schellenberg, Gerard D, Geschwind, Daniel H, and Hakonarson, Hakon
Subjects: Humans, Genetic Predisposition to Disease, Ubiquitin-Protein Ligases, Cell Adhesion Molecules, Neuronal, Nerve Tissue Proteins, Case-Control Studies, Cohort Studies, Pedigree, Autistic Disorder, Gene Duplication, Sequence Deletion, Gene Dosage, Exons, Adolescent, Child, Child, Preschool, Female, Male, Genome-Wide Association Study, Young Adult, Cell Adhesion Molecules, Neuronal, Preschool, Genetics, Developmental Biology
Abstract: The genetics underlying the autism spectrum disorders (ASDs) is complex and remains poorly understood. Previous work has demonstrated an important role for structural variation in a subset of cases, but has lacked the resolution necessary to move beyond detection of large regions of potential interest to identification of individual genes. To pinpoint genes likely to contribute to ASD etiology, we performed high density genotyping in 912 multiplex families from the Autism Genetics Resource Exchange (AGRE) collection and contrasted results to those obtained for 1,488 healthy controls. Through prioritization of exonic deletions (eDels), exonic duplications (eDups), and whole gene duplication events (gDups), we identified more than 150 loci harboring rare variants in multiple unrelated probands, but no controls. Importantly, 27 of these were confirmed on examination of an independent replication cohort comprised of 859 cases and an additional 1,051 controls. Rare variants at known loci, including exonic deletions at NRXN1 and whole gene duplications encompassing UBE3A and several other genes in the 15q11-q13 region, were observed in the course of these analyses. Strong support was likewise observed for previously unreported genes such as BZRAP1, an adaptor molecule known to regulate synaptic transmission, with eDels or eDups observed in twelve unrelated cases but no controls (p = 2.3x10(-5)). Less is known about MDGA2, likewise observed to be case-specific (p = 1.3x10(-4)). But, it is notable that the encoded protein shows an unexpectedly high similarity to Contactin 4 (BLAST E-value = 3x10(-39)), which has also been linked to disease. That hundreds of distinct rare variants were each seen only once further highlights complexity in the ASDs and points to the continued need for larger cohorts.
Published: 2009

4. Mapping autism risk loci using genetic linkage and chromosomal rearrangements

Author: Szatmari, Peter, Paterson, Andrew D, Zwaigenbaum, Lonnie, Roberts, Wendy, Brian, Jessica, Liu, Xiao-Qing, Vincent, John B, Skaug, Jennifer L, Thompson, Ann P, Senman, Lili, Feuk, Lars, Qian, Cheng, Bryson, Susan E, Jones, Marshall B, Marshall, Christian R, Scherer, Stephen W, Vieland, Veronica J, Bartlett, Christopher, Mangin, La Vonne, Goedken, Rhinda, Segre, Alberto, Pericak-Vance, Margaret A, Cuccaro, Michael L, Gilbert, John R, Wright, Harry H, Abramson, Ruth K, Betancur, Catalina, Bourgeron, Thomas, Gillberg, Christopher, Leboyer, Marion, Buxbaum, Joseph D, Davis, Kenneth L, Hollander, Eric, Silverman, Jeremy M, Hallmayer, Joachim, Lotspeich, Linda, Sutcliffe, James S, Haines, Jonathan L, Folstein, Susan E, Piven, Joseph, Wassink, Thomas H, Sheffield, Val, Geschwind, Daniel H, Bucan, Maja, Brown, W Ted, Cantor, Rita M, Constantino, John N, Gilliam, T Conrad, Herbert, Martha, LaJonchere, Clara, Ledbetter, David H, Lese-Martin, Christa, Miller, Janet, Nelson, Stan, Samango-Sprouse, Carol A, Spence, Sarah, State, Matthew, Tanzi, Rudolph E, Coon, Hilary, Dawson, Geraldine, Devlin, Bernie, Estes, Annette, Flodman, Pamela, Klei, Lambertus, McMahon, William M, Minshew, Nancy, Munson, Jeff, Korvatska, Elena, Rodier, Patricia M, Schellenberg, Gerard D, Smith, Moyra, Spence, M Anne, Stodgell, Chris, Tepper, Ping Guo, Wijsman, Ellen M, Yu, Chang-En, Roge, Bernadette, Mantoulan, Carine, Wittemeyer, Kerstin, Poustka, Annemarie, Felder, Barbel, Klauck, Sabine M, Schuster, Claudia, Poustka, Fritz, Boelte, Sven, Feineis-Matthews, Sabine, Herbrecht, Evelyn, Schmoetzer, Gabi, Tsiantis, John, Papanikolaou, Katerina, Maestrini, Elena, Bacchelli, Elena, Blasi, Francesca, Carone, Simona, Toma, Claudio, Van Engeland, Herman, de Jonge, Maretha, Kemner, Chantal, Koop, Frederike, and Langemeijer, Marjolijn
Subjects: Biological Sciences, Genetics, Human Genome, Brain Disorders, Intellectual and Developmental Disabilities (IDD), Mental Health, Pediatric Research Initiative, Pediatric, Autism, Autistic Disorder, Chromosome Aberrations, Chromosome Mapping, Family, Female, Genetic Linkage, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Humans, Lod Score, Male, Risk Factors, Autism Genome Project Consortium, glutamic acid, neurexin, neuroligin, adult, analytical equipment, article, autism, chromosome 11p, chromosome rearrangement, controlled study, family, female, gene locus, gene mapping, genetic analysis, genetic linkage, genetic risk, genetic variability, human, major clinical study, male, microarray analysis, priority journal, sample size, single nucleotide polymorphism, synaptogenesis, Genetic Screening, Linkage, Variation, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract: Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 [corrected] families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
Published: 2007

5. Mapping autism risk loci using genetic linkage and chromosomal rearrangements.

Author: Autism Genome Project Consortium, Szatmari, Peter, Paterson, Andrew D, Zwaigenbaum, Lonnie, Roberts, Wendy, Brian, Jessica, Liu, Xiao-Qing, Vincent, John B, Skaug, Jennifer L, Thompson, Ann P, Senman, Lili, Feuk, Lars, Qian, Cheng, Bryson, Susan E, Jones, Marshall B, Marshall, Christian R, Scherer, Stephen W, Vieland, Veronica J, Bartlett, Christopher, Mangin, La Vonne, Goedken, Rhinda, Segre, Alberto, Pericak-Vance, Margaret A, Cuccaro, Michael L, Gilbert, John R, Wright, Harry H, Abramson, Ruth K, Betancur, Catalina, Bourgeron, Thomas, Gillberg, Christopher, Leboyer, Marion, Buxbaum, Joseph D, Davis, Kenneth L, Hollander, Eric, Silverman, Jeremy M, Hallmayer, Joachim, Lotspeich, Linda, Sutcliffe, James S, Haines, Jonathan L, Folstein, Susan E, Piven, Joseph, Wassink, Thomas H, Sheffield, Val, Geschwind, Daniel H, Bucan, Maja, Brown, W Ted, Cantor, Rita M, Constantino, John N, Gilliam, T Conrad, Herbert, Martha, Lajonchere, Clara, Ledbetter, David H, Lese-Martin, Christa, Miller, Janet, Nelson, Stan, Samango-Sprouse, Carol A, Spence, Sarah, State, Matthew, Tanzi, Rudolph E, Coon, Hilary, Dawson, Geraldine, Devlin, Bernie, Estes, Annette, Flodman, Pamela, Klei, Lambertus, McMahon, William M, Minshew, Nancy, Munson, Jeff, Korvatska, Elena, Rodier, Patricia M, Schellenberg, Gerard D, Smith, Moyra, Spence, M Anne, Stodgell, Chris, Tepper, Ping Guo, Wijsman, Ellen M, Yu, Chang-En, Rogé, Bernadette, Mantoulan, Carine, Wittemeyer, Kerstin, Poustka, Annemarie, Felder, Bärbel, Klauck, Sabine M, Schuster, Claudia, Poustka, Fritz, Bölte, Sven, Feineis-Matthews, Sabine, Herbrecht, Evelyn, Schmötzer, Gabi, Tsiantis, John, Papanikolaou, Katerina, Maestrini, Elena, Bacchelli, Elena, Blasi, Francesca, Carone, Simona, Toma, Claudio, Van Engeland, Herman, de Jonge, Maretha, Kemner, Chantal, and Koop, Frederieke
Subjects: Autism Genome Project Consortium, Humans, Chromosome Aberrations, Genetic Predisposition to Disease, Risk Factors, Chromosome Mapping, Family, Autistic Disorder, Lod Score, Female, Male, Genetic Variation, Genetic Testing, Genetic Linkage, Intellectual and Developmental Disabilities (IDD), Pediatric Research Initiative, Human Genome, Pediatric, Brain Disorders, Genetics, Autism, Mental Health, glutamic acid, neurexin, neuroligin, adult, analytical equipment, article, autism, chromosome 11p, chromosome rearrangement, controlled study, family, female, gene locus, gene mapping, genetic analysis, genetic linkage, genetic risk, genetic variability, human, major clinical study, male, microarray analysis, priority journal, sample size, single nucleotide polymorphism, synaptogenesis, Genetic Screening, Linkage, Variation, Developmental Biology, Biological Sciences, Medical and Health Sciences
Abstract: Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 [corrected] families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
Published: 2007

6. Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene

Author: Wassink, Thomas H, Piven, Joseph, Vieland, Veronica J, Jenkins, Laura, Frantz, Rebecca, Bartlett, Christopher W, Goedken, Rhinda, Childress, Deb, Spence, M Anne, Smith, Moyra, and Sheffield, Val C
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Clinical Research, Intellectual and Developmental Disabilities (IDD), Pediatric, Neurosciences, Brain Disorders, Autism, Mental Health, Human Genome, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Mental health, ADP-Ribosylation Factors, Amino Acid Sequence, Autistic Disorder, Chromosome Deletion, Chromosomes, Human, Pair 2, DNA Mutational Analysis, Family Health, Female, GTPase-Activating Proteins, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Humans, Lod Score, Male, Microsatellite Repeats, Mutation, Polymorphism, Genetic, Sequence Homology, Amino Acid, Telomere, linkage, linkage disequilibrium, autistic disorder, chromosomal abnormalities, Autistic disorder, Chromosomal abnormalities, Linkage, Linkage disequilibrium, arginine, glycine, serine, amino acid substitution, article, autism, CENTG2 gene, chromosome 2q, developmental disorder, DNA polymorphism, fluorescence in situ hybridization, gene, gene deletion, gene linkage disequilibrium, genetic analysis, genetic linkage, genetic susceptibility, genotype, human, priority journal, Clinical Sciences, Clinical sciences
Abstract: Autism is a highly heritable neurodevelopmental syndrome with a complex genetic etiology for which no disease genes have yet been definitively identified. We ascertained three subjects with autism spectrum disorders and chromosome 2q37.3 terminal deletions, and refined the deletion breakpoint regions using polymorphism mapping and fluorescence in situ hybridization (FISH) probes. We then genotyped polymorphic markers downstream from the breakpoint region in a sample of autism affected sibling pair families. Both the chromosomal breakpoints and linkage analyses focused our attention on the gene centaurin gamma-2 (CENTG2), an attractive candidate gene based also on its function and pattern of expression. We therefore assessed CENTG2 for its involvement in autism by (1) screening its exons for variants in 199 autistic and 160 non-autistic individuals, and (2) genotyping and assessing intra-genic polymorphisms for linkage and linkage disequilibrium (LD). The exon screen revealed a Ser --> Gly substitution in one proband, an Arg --> Gly substitution in another, and a number of additional variants unique to the autism families. No unique variants were found in the control subjects. The genotyping produced strong evidence for linkage from two intronic polymorphisms, with a maximum two-point HLOD value of 3.96 and a posterior probability of linkage (PPL) of 51%. These results were contradicted, however, by substantially weaker evidence for linkage from multi-point analyses and by no evidence of LD. We conclude, therefore, that 2q37.3 continues to be a region of interest for autism susceptibility, and that CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism.
Published: 2005

7. Modeling Human Cerebellar Development In Vitro in 2D Structure

Author: Madencioglu, Deniz A., primary, Kruth, Karina A., primary, Wassink, Thomas H., primary, Magnotta, Vincent A., primary, Wemmie, John A., primary, and Williams, Aislinn J., primary
Published: 2022
Full Text: View/download PDF

8. Genetic influences on cognitive endophenotypes in schizophrenia

Author: Yeo, Ronald A., Gangestad, Steven W., Walton, Esther, Ehrlich, Stefan, Pommy, Jessica, Turner, Jessica A., Liu, Jingyu, Mayer, Andrew R., Schulz, S. Charles, Ho, Beng-Choon, Bustillo, Juan R., Wassink, Thomas H., Sponheim, Scott R., Morrow, Eric M., and Calhoun, Vince D.
Published: 2014
Full Text: View/download PDF

9. Autism and Related Disorders

Author: Sikich, Lin Marie, Wassink, Thomas H., Pelphrey, Kevin A., Piven, Joseph, Runge, Marschall S., editor, and Patterson, Cam, editor
Published: 2006
Full Text: View/download PDF

10. Genetic variation in GAD1 is associated with cortical thickness in the parahippocampal gyrus

Author: Brauns, Stefan, Gollub, Randy L., Walton, Esther, Hass, Johanna, Smolka, Michael N., White, Tonya, Wassink, Thomas H., Calhoun, Vince D., and Ehrlich, Stefan
Published: 2013
Full Text: View/download PDF

11. Systematic Screening for Subtelomeric Anomalies in a Clinical Sample of Autism

Author: Wassink, Thomas H., Losh, Molly, and Piven, Joseph
Abstract: High-resolution karyotyping detects cytogenetic anomalies in 5-10% of cases of autism. Karyotyping, however, may fail to detect abnormalities of chromosome subtelomeres, which are gene rich regions prone to anomalies. We assessed whether panels of FISH probes targeted for subtelomeres could detect abnormalities beyond those identified by karyotyping in 104 individuals with Pervasive Developmental Disorders (PDDs) drawn from a general clinical population. Four anomalies were detected by karyotyping, while no additional anomalies were detected by subtelomere FISH or by probes targeted for 15q11.2q13 or 22q11.2 in subgroups of our sample. We conclude that while karyotyping may be more broadly indicated for autism than previously supposed, subtelomere FISH appears less likely to be a useful screening tool for unselected PDD populations.
Published: 2007
Full Text: View/download PDF

12. Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3–90 years

Author: Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, Van't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Williams, Steven C R, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Frangou, Sophia, other, and, Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, Van't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Williams, Steven C R, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Frangou, Sophia, and other, and
Abstract: Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
Published: 2022

13. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

Author: Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C R, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J, Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, van 't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Dima, Danai, other, and, Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C R, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J, Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, van 't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Dima, Danai, and other, and
Abstract: Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
Published: 2022

14. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

Author: European Commission, National Institute of Child Health and Human Development (US), QIMR Berghofer Medical Research Institute (Australia), University of Queensland, National Cancer Institute (US), Dutch Research Council, Netherlands Organisation for Health Research and Development, National Institute of Mental Health (US), European Research Council, National Center for Advancing Translational Sciences (US), Medical Research Council (UK), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, South-Eastern Norway Regional Health Authority, Research Council of Norway, Icahn School of Medicine at Mount Sinai, South London and Maudsley NHS Foundation Trust, NHS Foundation Trust, National Institute for Health Research (UK), Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C. R., Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H., Weber, Bernd, Bertolino, Alessandro, Wen, Wei, Kalnin, Andrew, West, John D., Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Wittfeld, Katharina, Wolf, Daniel H., Worker, Amanda, Wright, Margaret J., Yang, Kun, Bonvino, Aurora, Kanai, Ryota, Yoncheva, Yulyia, Zanetti, Marcus V., Ziegler, Georg C., Karolinska Schizophrenia Project, Thompson, Paul M., Dima, Danai, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Klein, Marieke, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Klyushnik, Tatyana P., Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Koenders, Laura, Crone, Eveline A., Dale, Anders M., Dannlowski, Udo, Davey, Christopher, Geus, Eco J. C. de, Haan, Lieuwe de, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Koops, Sanne, Doan, Nhat Trung, Dørum, Erlend S., Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Krämer, Bernd, Fuentes-Claramonte, Paola, Glahn, David C., Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Kuntsi, Jonna, Gur, Ruben C., Hahn, Tim, Harrison, Ben J., Hartman, Catharine A., Hatton, Sean N., Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P., Hickie, Ian B., Ho, Beng-Choon, Lagopoulos, Jim, Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Lázaro, Luisa, Jernigan, Terry L., Jiang, Jiyang, Jönsson, Erik G., Joska, John A., Kahn, René S., Andersson, Micael, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, Andreasen, Nancy C., McDonald, Colm, McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Andreassen, Ole A., Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Asherson, Philip, Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Banaschewski, Tobias, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W., Bargalló, Núria, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Swagerman, Suzanne C., Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Tomyshev, Alexander S., Baumeister, Sarah, Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Turner, Jessica A., Uhlmann, Anne, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van 't Ent, Dennis, van Erp, Theo G. M., Baur-Streubel, Ramona, Veer, Ilya M., Veltman, Dick J., European Commission, National Institute of Child Health and Human Development (US), QIMR Berghofer Medical Research Institute (Australia), University of Queensland, National Cancer Institute (US), Dutch Research Council, Netherlands Organisation for Health Research and Development, National Institute of Mental Health (US), European Research Council, National Center for Advancing Translational Sciences (US), Medical Research Council (UK), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, South-Eastern Norway Regional Health Authority, Research Council of Norway, Icahn School of Medicine at Mount Sinai, South London and Maudsley NHS Foundation Trust, NHS Foundation Trust, National Institute for Health Research (UK), Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C. R., Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H., Weber, Bernd, Bertolino, Alessandro, Wen, Wei, Kalnin, Andrew, West, John D., Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Wittfeld, Katharina, Wolf, Daniel H., Worker, Amanda, Wright, Margaret J., Yang, Kun, Bonvino, Aurora, Kanai, Ryota, Yoncheva, Yulyia, Zanetti, Marcus V., Ziegler, Georg C., Karolinska Schizophrenia Project, Thompson, Paul M., Dima, Danai, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Klein, Marieke, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Klyushnik, Tatyana P., Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Koenders, Laura, Crone, Eveline A., Dale, Anders M., Dannlowski, Udo, Davey, Christopher, Geus, Eco J. C. de, Haan, Lieuwe de, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Koops, Sanne, Doan, Nhat Trung, Dørum, Erlend S., Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Krämer, Bernd, Fuentes-Claramonte, Paola, Glahn, David C., Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Kuntsi, Jonna, Gur, Ruben C., Hahn, Tim, Harrison, Ben J., Hartman, Catharine A., Hatton, Sean N., Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P., Hickie, Ian B., Ho, Beng-Choon, Lagopoulos, Jim, Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Lázaro, Luisa, Jernigan, Terry L., Jiang, Jiyang, Jönsson, Erik G., Joska, John A., Kahn, René S., Andersson, Micael, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, Andreasen, Nancy C., McDonald, Colm, McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Andreassen, Ole A., Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Asherson, Philip, Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Banaschewski, Tobias, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W., Bargalló, Núria, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Swagerman, Suzanne C., Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Tomyshev, Alexander S., Baumeister, Sarah, Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Turner, Jessica A., Uhlmann, Anne, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van 't Ent, Dennis, van Erp, Theo G. M., Baur-Streubel, Ramona, Veer, Ilya M., and Veltman, Dick J.
Abstract: Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
Published: 2022

15. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Author: National Institute of Mental Health (US), Karolinska Institute, Stockholm County Council, South-Eastern Norway Regional Health Authority, German Centre for Cardiovascular Research, Siemens Healthcare, University of Queensland, Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), National Health and Medical Research Council (Australia), National Institute on Drug Abuse (US), Indiana State Department of Health, Parents of children with epilepsy, Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures, Epilepsy Foundation, American Epilepsy Society, Knut and Alice Wallenberg Foundation, European Commission, Dutch Research Council, Netherlands Organization for Scientific Research, Netherlands Brain Foundation, Utrecht University, European Research Council, National Center for Advancing Translational Sciences (US), National Institutes of Health (US), National Center for Research Resources (US), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, Kings College London, South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre (UK), National Institute for Health Research (UK), Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Tordesillas-Gutiérrez, Diana, Ehrlich, Stefan, Bargalló, Núria, Weber, Bernd, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Erk, Susanne, West, John D., Smoller, Jordan W., Sommer, Iris, Wen, Wei, Baumeister, Sarah, Hartman, Catharine A., Trollor, Julian N., Baur-Streubel, Ramona, Turner, Jessica A., Uhlmann, Anne, Espeseth, Thomas, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van't Ent, Dennis, van Erp, Theo G. M., Hatton, Sean N., Bonvino, Aurora, Veer, Ilya M., Veltman, Dick J., Fatouros-Bergman, Helena, Bertolino, Alessandro, Voineskos, Aristotle, Kanai, Ryota, Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Williams, Steven C. R., Heinz, Andreas, Wittfeld, Katharina, Wolf, Daniel H., Fisher, Simon E., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Klein, Marieke, Boomsma, Dorret I., Zanetti, Marcus V., Ziegler, Georg C., Heslenfeld, Dirk J., Thompson, Paul M., Fouche, Jean-Paul, Frangou, Sophia, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Klyushnik, Tatyana P., Brouwer, Rachel M., Buitelaar, Jan K., Hibar, Derrek P., Franke, Barbara, Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Koenders, Laura, Chaim-Avancini, Tiffany M., Frodl, Thomas, Hickie, Ian B., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dannlowski, Udo, Fuentes-Claramonte, Paola, Koops, Sanne, Ho, Beng-Choon, Dale, Anders M., Davey, Christopher, Geus, Eco J. C. de, de Haan, Lieuwe, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Hohmann, Sarah, Doan, Nhat Trung, Dørum, Erlend S., Hoekstra, Pieter J., Krämer, Bernd, Soriano-Mas, Carles, Glahn, David C., Kuntsi, Jonna, Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Stein, Dan J., Lázaro, Luisa, Gur, Ruben C., Hahn, Tim, Lagopoulos, Jim, Harrison, Ben J., Völzke, Henry, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Strike, Lachlan T., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Walter, Henrik, Lebedeva, Irina, Jönsson, Erik G., Joska, John A., Swagerman, Suzanne C., Kahn, René S., Kalnin, Andrew, Andreasen, Nancy C., Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Walton, Esther, Maingault, Sophie, Martin, Nicholas G., Tamnes, Christian K., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, Andreassen, Ole A., McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., Wang, Lei, McPhilemy, Genevieve, Temmingh, Henk S., Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Asherson, Philip, Nakao, Tomohiro, Nordvik, Jan E., Wang, Yang, Thomopoulos, Sophia I., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Banaschewski, Tobias, Potkin, Steven G., Tomyshev, Alexander S., Wassink, Thomas H., National Institute of Mental Health (US), Karolinska Institute, Stockholm County Council, South-Eastern Norway Regional Health Authority, German Centre for Cardiovascular Research, Siemens Healthcare, University of Queensland, Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), National Health and Medical Research Council (Australia), National Institute on Drug Abuse (US), Indiana State Department of Health, Parents of children with epilepsy, Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures, Epilepsy Foundation, American Epilepsy Society, Knut and Alice Wallenberg Foundation, European Commission, Dutch Research Council, Netherlands Organization for Scientific Research, Netherlands Brain Foundation, Utrecht University, European Research Council, National Center for Advancing Translational Sciences (US), National Institutes of Health (US), National Center for Research Resources (US), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, Kings College London, South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre (UK), National Institute for Health Research (UK), Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Tordesillas-Gutiérrez, Diana, Ehrlich, Stefan, Bargalló, Núria, Weber, Bernd, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Erk, Susanne, West, John D., Smoller, Jordan W., Sommer, Iris, Wen, Wei, Baumeister, Sarah, Hartman, Catharine A., Trollor, Julian N., Baur-Streubel, Ramona, Turner, Jessica A., Uhlmann, Anne, Espeseth, Thomas, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van't Ent, Dennis, van Erp, Theo G. M., Hatton, Sean N., Bonvino, Aurora, Veer, Ilya M., Veltman, Dick J., Fatouros-Bergman, Helena, Bertolino, Alessandro, Voineskos, Aristotle, Kanai, Ryota, Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Williams, Steven C. R., Heinz, Andreas, Wittfeld, Katharina, Wolf, Daniel H., Fisher, Simon E., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Klein, Marieke, Boomsma, Dorret I., Zanetti, Marcus V., Ziegler, Georg C., Heslenfeld, Dirk J., Thompson, Paul M., Fouche, Jean-Paul, Frangou, Sophia, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Klyushnik, Tatyana P., Brouwer, Rachel M., Buitelaar, Jan K., Hibar, Derrek P., Franke, Barbara, Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Koenders, Laura, Chaim-Avancini, Tiffany M., Frodl, Thomas, Hickie, Ian B., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dannlowski, Udo, Fuentes-Claramonte, Paola, Koops, Sanne, Ho, Beng-Choon, Dale, Anders M., Davey, Christopher, Geus, Eco J. C. de, de Haan, Lieuwe, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Hohmann, Sarah, Doan, Nhat Trung, Dørum, Erlend S., Hoekstra, Pieter J., Krämer, Bernd, Soriano-Mas, Carles, Glahn, David C., Kuntsi, Jonna, Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Stein, Dan J., Lázaro, Luisa, Gur, Ruben C., Hahn, Tim, Lagopoulos, Jim, Harrison, Ben J., Völzke, Henry, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Strike, Lachlan T., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Walter, Henrik, Lebedeva, Irina, Jönsson, Erik G., Joska, John A., Swagerman, Suzanne C., Kahn, René S., Kalnin, Andrew, Andreasen, Nancy C., Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Walton, Esther, Maingault, Sophie, Martin, Nicholas G., Tamnes, Christian K., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, Andreassen, Ole A., McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., Wang, Lei, McPhilemy, Genevieve, Temmingh, Henk S., Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Asherson, Philip, Nakao, Tomohiro, Nordvik, Jan E., Wang, Yang, Thomopoulos, Sophia I., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Banaschewski, Tobias, Potkin, Steven G., Tomyshev, Alexander S., and Wassink, Thomas H.
Abstract: Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
Published: 2022

16. The Search for Autism Disease Genes

Author: Wassink, Thomas H., Brzustowicz, Linda M., and Bartlett, Christopher W.
Abstract: Autism is a heritable disorder characterized by phenotypic and genetic complexity. This review begins by surveying current linkage, gene association, and cytogenetic studies performed with the goal of identifying autism disease susceptibility variants. Though numerous linkages and associations have been identified, they tend to diminish upon closer examination or attempted replication. The review therefore explores challenges to current methodologies presented by the complexities of autism that might underlie some of the current difficulties, and finishes by describing emerging phenotypic, statistical, and molecular investigational approaches that offer hope of overcoming those challenges. (Contains 1 table and 3 figures.)
Published: 2004
Full Text: View/download PDF

17. Multifaceted genomic risk for brain function in schizophrenia

Author: Chen, Jiayu, Calhoun, Vince D., Pearlson, Godfrey D., Ehrlich, Stefan, Turner, Jessica A., Ho, Beng-Choon, Wassink, Thomas H., Michael, Andrew M., and Liu, Jingyu
Published: 2012
Full Text: View/download PDF

18. MTHFR 677C → T Genotype Disrupts Prefrontal Function in Schizophrenia through an Interaction with COMT 158Val → Met

Author: Roffman, Joshua L., Gollub, Randy L., Calhoun, Vince D., Wassink, Thomas H., Weiss, Anthony P., Ho, Beng C., White, Tonya, Clark, Vincent P., Fries, Jill, Andreasen, Nancy C., Goff, Donald C., and Manoach, Dara S.
Published: 2008
Full Text: View/download PDF

19. DISC1 is associated with cortical thickness and neural efficiency

Author: Brauns, Stefan, Gollub, Randy L., Roffman, Joshua L., Yendiki, Anastasia, Ho, Beng-Choon, Wassink, Thomas H., Heinz, Andreas, and Ehrlich, Stefan
Published: 2011
Full Text: View/download PDF

20. Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia

Author: Ho, Beng-Choon, Wassink, Thomas H., Ziebell, Steven, and Andreasen, Nancy C.
Published: 2011
Full Text: View/download PDF

21. Common genetic variants influence human subcortical brain structures

Author: Hibar, Derrek P., Stein, Jason L., Renteria, Miguel E., Arias-Vasquez, Alejandro, Desrivières, Sylvane, Jahanshad, Neda, Toro, Roberto, Wittfeld, Katharina, Abramovic, Lucija, Andersson, Micael, Aribisala, Benjamin S., Armstrong, Nicola J., Bernard, Manon, Bohlken, Marc M., Boks, Marco P., Bralten, Janita, Brown, Andrew A., Chakravarty, Mallar M., Chen, Qiang, Ching, Christopher R. K., Cuellar-Partida, Gabriel, den Braber, Anouk, Giddaluru, Sudheer, Goldman, Aaron L., Grimm, Oliver, Guadalupe, Tulio, Hass, Johanna, Woldehawariat, Girma, Holmes, Avram J., Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H., Olde Loohuis, Loes M., Luciano, Michelle, Macare, Christine, Mather, Karen A., Mattheisen, Manuel, Milaneschi, Yuri, Nho, Kwangsik, Papmeyer, Martina, Ramasamy, Adaikalavan, Risacher, Shannon L., Roiz-Santiañez, Roberto, Rose, Emma J., Salami, Alireza, Sämann, Philipp G., Schmaal, Lianne, Schork, Andrew J., Shin, Jean, Strike, Lachlan T., Teumer, Alexander, van Donkelaar, Marjolein M. J., van Eijk, Kristel R., Walters, Raymond K., Westlye, Lars T., Whelan, Christopher D., Winkler, Anderson M., Zwiers, Marcel P., Alhusaini, Saud, Athanasiu, Lavinia, Ehrlich, Stefan, Hakobjan, Marina M. H., Hartberg, Cecilie B., Haukvik, Unn K., Heister, Angelien J. G. A. M., Hoehn, David, Kasperaviciute, Dalia, Liewald, David C. M., Lopez, Lorna M., Makkinje, Remco R. R., Matarin, Mar, Naber, Marlies A. M., McKay, Reese D., Needham, Margaret, Nugent, Allison C., Pütz, Benno, Royle, Natalie A., Shen, Li, Sprooten, Emma, Trabzuni, Daniah, van der Marel, Saskia S. L., van Hulzen, Kimm J. E., Walton, Esther, Wolf, Christiane, Almasy, Laura, Ames, David, Arepalli, Sampath, Assareh, Amelia A., Bastin, Mark E., Brodaty, Henry, Bulayeva, Kazima B., Carless, Melanie A., Cichon, Sven, Corvin, Aiden, Curran, Joanne E., Czisch, Michael, de Zubicaray, Greig I., Dillman, Allissa, Duggirala, Ravi, Dyer, Thomas D., Erk, Susanne, Fedko, Iryna O., Ferrucci, Luigi, Foroud, Tatiana M., Fox, Peter T., Fukunaga, Masaki, Gibbs, Raphael J., Göring, Harald H. H., Green, Robert C., Guelfi, Sebastian, Hansell, Narelle K., Hartman, Catharina A., Hegenscheid, Katrin, Heinz, Andreas, Hernandez, Dena G., Heslenfeld, Dirk J., Hoekstra, Pieter J., Holsboer, Florian, Homuth, Georg, Hottenga, Jouke-Jan, Ikeda, Masashi, Jack, Clifford R., Jr, Jenkinson, Mark, Johnson, Robert, Kanai, Ryota, Keil, Maria, Kent, Jack W., Jr, Kochunov, Peter, Kwok, John B., Lawrie, Stephen M., Liu, Xinmin, Longo, Dan L., McMahon, Katie L., Meisenzahl, Eva, Melle, Ingrid, Mohnke, Sebastian, Montgomery, Grant W., Mostert, Jeanette C., Mühleisen, Thomas W., Nalls, Michael A., Nichols, Thomas E., Nilsson, Lars G., Nöthen, Markus M., Ohi, Kazutaka, Olvera, Rene L., Perez-Iglesias, Rocio, Pike, Bruce G., Potkin, Steven G., Reinvang, Ivar, Reppermund, Simone, Rietschel, Marcella, Romanczuk-Seiferth, Nina, Rosen, Glenn D., Rujescu, Dan, Schnell, Knut, Schofield, Peter R., Smith, Colin, Steen, Vidar M., Sussmann, Jessika E., Thalamuthu, Anbupalam, Toga, Arthur W., Traynor, Bryan J., Troncoso, Juan, Turner, Jessica A., Valdés Hernández, Maria C., van ʼt Ent, Dennis, van der Brug, Marcel, van der Wee, Nic J. A., van Tol, Marie-Jose, Veltman, Dick J., Wassink, Thomas H., Westman, Eric, Zielke, Ronald H., Zonderman, Alan B., Ashbrook, David G., Hager, Reinmar, Lu, Lu, McMahon, Francis J., Morris, Derek W., Williams, Robert W., Brunner, Han G., Buckner, Randy L., Buitelaar, Jan K., Cahn, Wiepke, Calhoun, Vince D., Cavalleri, Gianpiero L., Crespo-Facorro, Benedicto, Dale, Anders M., Davies, Gareth E., Delanty, Norman, Depondt, Chantal, Djurovic, Srdjan, Drevets, Wayne C., Espeseth, Thomas, Gollub, Randy L., Ho, Beng-Choon, Hoffmann, Wolfgang, Hosten, Norbert, Kahn, René S., Le Hellard, Stephanie, Meyer-Lindenberg, Andreas, Müller-Myhsok, Bertram, Nauck, Matthias, Nyberg, Lars, Pandolfo, Massimo, Penninx, Brenda W. J. H., Roffman, Joshua L., Sisodiya, Sanjay M., Smoller, Jordan W., van Bokhoven, Hans, van Haren, Neeltje E. M., Völzke, Henry, Walter, Henrik, Weiner, Michael W., Wen, Wei, White, Tonya, Agartz, Ingrid, Andreassen, Ole A., Blangero, John, Boomsma, Dorret I., Brouwer, Rachel M., Cannon, Dara M., Cookson, Mark R., de Geus, Eco J. C., Deary, Ian J., Donohoe, Gary, Fernández, Guillén, Fisher, Simon E., Francks, Clyde, Glahn, David C., Grabe, Hans J., Gruber, Oliver, Hardy, John, Hashimoto, Ryota, Hulshoff Pol, Hilleke E., Jönsson, Erik G., Kloszewska, Iwona, Lovestone, Simon, Mattay, Venkata S., Mecocci, Patrizia, McDonald, Colm, McIntosh, Andrew M., Ophoff, Roel A., Paus, Tomas, Pausova, Zdenka, Ryten, Mina, Sachdev, Perminder S., Saykin, Andrew J., Simmons, Andy, Singleton, Andrew, Soininen, Hilkka, Wardlaw, Joanna M., Weale, Michael E., Weinberger, Daniel R., Adams, Hieab H. H., Launer, Lenore J., Seiler, Stephan, Schmidt, Reinhold, Chauhan, Ganesh, Satizabal, Claudia L., Becker, James T., Yanek, Lisa, van der Lee, Sven J., Ebling, Maritza, Fischl, Bruce, Longstreth, W. T., Jr, Greve, Douglas, Schmidt, Helena, Nyquist, Paul, Vinke, Louis N., van Duijn, Cornelia M., Xue, Luting, Mazoyer, Bernard, Bis, Joshua C., Gudnason, Vilmundur, Seshadri, Sudha, Ikram, Arfan M., Martin, Nicholas G., Wright, Margaret J., Schumann, Gunter, Franke, Barbara, Thompson, Paul M., and Medland, Sarah E.
Published: 2015
Full Text: View/download PDF

22. A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model

Author: Rudd, Danielle S., Axelsen, Michael, Epping, Eric A., Andreasen, Nancy C., and Wassink, Thomas H.
Published: 2014
Full Text: View/download PDF

23. Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years

Author: Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C. R., Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Anton, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Andreasen, Nancy C., Andreassen, Ole A., Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dale, Anders M., Dannlowski, Udo, Davey, Christopher, de Geus, Eco J. C., de Haan, Lieuwe, de Zubicaray, Greig I., den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S., Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C., Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Gur, Ruben C., Hahn, Tim, Harrison, Ben J., Hartman, Catharine A., Hatton, Sean N., Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P., Hickie, Ian B., Ho, Beng-Choon, Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Jönsson, Erik G., Joska, John A., Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P., Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W., Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Swagerman, Suzanne C., Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Turner, Jessica A., Uhlmann, Anne, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van 't Ent, Dennis, van Erp, Theo G. M., Veer, Ilya M., Veltman, Dick J., Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H., Weber, Bernd, Wen, Wei, West, John D., Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Wittfeld, Katharina, Wolf, Daniel H., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V., Ziegler, Georg C., Thompson, Paul M., Dima, Danai, Universitat Autònoma de Barcelona, Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C. R., Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Anton, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Andreasen, Nancy C., Andreassen, Ole A., Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dale, Anders M., Dannlowski, Udo, Davey, Christopher, de Geus, Eco J. C., de Haan, Lieuwe, de Zubicaray, Greig I., den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S., Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C., Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Gur, Ruben C., Hahn, Tim, Harrison, Ben J., Hartman, Catharine A., Hatton, Sean N., Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P., Hickie, Ian B., Ho, Beng-Choon, Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Jönsson, Erik G., Joska, John A., Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P., Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W., Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Swagerman, Suzanne C., Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Turner, Jessica A., Uhlmann, Anne, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van 't Ent, Dennis, van Erp, Theo G. M., Veer, Ilya M., Veltman, Dick J., Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H., Weber, Bernd, Wen, Wei, West, John D., Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Wittfeld, Katharina, Wolf, Daniel H., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V., Ziegler, Georg C., Thompson, Paul M., Dima, Danai, and Universitat Autònoma de Barcelona
Abstract: Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes. We used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness.
Published: 2021

24. Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3-90 years

Author: Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Anton, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Andreasen, Nancy C., Andreassen, Ole A., Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dannlowski, Udo, Dale, Anders M., Davey, Christopher, de Geus, Eco J. C., de Haan, Lieuwe, de Zubicaray, Greig I., den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S., Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C., Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Gur, Ruben C., Hahn, Tim, Harrison, Ben J., Hartman, Catharine A., Hatton, Sean N., Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P., Hickie, Ian B., Ho, Beng-Choon, Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Jönsson, Erik G., Joska, John A., Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P., Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W., Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Swagerman, Suzanne C., Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Turner, Jessica A., Uhlmann, Anne, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van't Ent, Dennis, van Erp, Theo G. M., Veer, Ilya M., Veltman, Dick J., Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H., Weber, Bernd, Wen, Wei, West, John D., Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Williams, Steven C. R., Wittfeld, Katharina, Wolf, Daniel H., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V., Ziegler, Georg C., Thompson, Paul M., Frangou, Sophia, Universitat Autònoma de Barcelona, Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Anton, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Andreasen, Nancy C., Andreassen, Ole A., Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dannlowski, Udo, Dale, Anders M., Davey, Christopher, de Geus, Eco J. C., de Haan, Lieuwe, de Zubicaray, Greig I., den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S., Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C., Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Gur, Ruben C., Hahn, Tim, Harrison, Ben J., Hartman, Catharine A., Hatton, Sean N., Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P., Hickie, Ian B., Ho, Beng-Choon, Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Jönsson, Erik G., Joska, John A., Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P., Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W., Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Swagerman, Suzanne C., Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Turner, Jessica A., Uhlmann, Anne, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van't Ent, Dennis, van Erp, Theo G. M., Veer, Ilya M., Veltman, Dick J., Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H., Weber, Bernd, Wen, Wei, West, John D., Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Williams, Steven C. R., Wittfeld, Katharina, Wolf, Daniel H., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V., Ziegler, Georg C., Thompson, Paul M., Frangou, Sophia, and Universitat Autònoma de Barcelona
Abstract: Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns. We analyzed subcortical volumes from 18,605 healthy individuals from multiple cross-sectional cohorts to infer age-related trajectories between the ages of 3 and 90 years.
Published: 2021

25. Genome-wide analysis of copy number variants in age-related macular degeneration

Author: Meyer, Kacie J., Davis, Lea K., Schindler, Emily I., Beck, John S., Rudd, Danielle S., Grundstad, A. Jason, Scheetz, Todd E., Braun, Terry A., Fingert, John H., Alward, Wallace L., Kwon, Young H., Folk, James C., Russell, Stephen R., Wassink, Thomas H., Stone, Edwin M., and Sheffield, Val C.
Published: 2011
Full Text: View/download PDF

26. Basic helix–loop–helix transcription factor NEUROG1 and schizophrenia: Effects on illness susceptibility, MRI brain morphometry and cognitive abilities

Author: Ho, Beng-Choon, Epping, Eric, Wang, Kai, Andreasen, Nancy C., Librant, Amy, and Wassink, Thomas H.
Published: 2008
Full Text: View/download PDF

27. Prefrontal Inefficiency Is Associated With Polygenic Risk for Schizophrenia

Author: Walton, Esther, Geisler, Daniel, Lee, Phil H., Hass, Johanna, Turner, Jessica A., Liu, Jingyu, Sponheim, Scott R., White, Tonya, Wassink, Thomas H., Roessner, Veit, Gollub, Randy L., Calhoun, Vince D., and Ehrlich, Stefan
Published: 2014
Full Text: View/download PDF

28. Common genetic variants on 5p14.1 associate with autism spectrum disorders

Author: Wang, Kai, Zhang, Haitao, Ma, Deqiong, Bucan, Maja, Glessner, Joseph T., Abrahams, Brett S., Salyakina, Daria, Imielinski, Marcin, Bradfield, Jonathan P., Sleiman, Patrick M.A., Kim, Cecilia E., Hou, Cuiping, Frackelton, Edward, Chiavacci, Rosetta, Takahashi, Nagahide, Sakurai, Takeshi, Rappaport, Eric, Lajonchere, Clara M., Munson, Jeffrey, Estes, Annette, Korvatska, Olena, Piven, Joseph, Sonnenblick, Lisa I., Retuerto, Ana I. Alvarez, Herman, Edward I., Hutman, Ted, Sigman, Marian, Ozonoff, Sally, Klin, Ami, Owley, Thomas, Sweeney, John A., Brune, Camille W., Cantor, Rita M., Bernier, Raphael, Gilbert, John R., Cuccaro, Michael L., McMahon, William M., Miller, Judith, State, Matthew W., Wassink, Thomas H., Coon, Hilary, Levy, Susan E., Schult, Robert T., Nurnberger, John I. Jr., Haines, Jonathan L., Sutcliffe, James S., Cook, Edwin H., Minshew, Nancy J., Buxbaums, Joseph D., Dawson, Geraldine, Grant, Struan F.A., Geschwind, Daniel H., Pericak-Vance, Margaret A., Schellenberg, Gerard D., and Hakonarson, Hakon
Subjects: Pervasive developmental disorders -- Genetic aspects -- Risk factors, Genetic research -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Genetic aspects, Risk factors
Abstract: Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and neuropsychiatric disorders characterized by deficits in verbal communication, impairment of social interaction, and restricted and repetitive patterns of interests and behaviour. To identify common genetic risk factors underlying ASDs, here we present the results of genome-wide association studies on a cohort of 780 families (3,101 subjects) with affected children, and a second cohort of 1,204 affected subjects and 6,491 control subjects, all of whom were of European ancestry. Six single nucleotide polymorphisms between cadherin 10 (CDH10) and cadherin 9 (CDH9)-two genes encoding neuronal cell-adhesion molecules-revealed strong association signals, with the most significant SNP being rs4307059 (P = 3.4 X [10.sup.-8], odds ratio =1.19). These signals were replicated in two independent cohorts, with combined Pvalues ranging from 7.4 X [10.sup.-8] to 2.1 X [10.sup.-10]. Our results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to our knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs., ASDs encompass a range of clinically defined conditions, including autism and pervasive developmental disorder not otherwise specified, which are more common and severe, as well as Asperger's syndrome, which appears [...]
Published: 2009

29. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

Author: Wang, Kai, Cai, Guiqing, Korvatska, Olena, Kim, Cecilia E., Wood, Shawn, Zhang, Haitao, Estes, Annette, Brune, Camille W., Bradfield, Jonathan P., Imielinski, Marcin, Frackelton, Edward C., Reichert, Jennifer, Crawford, Emily L., Munson, Jeffrey, Sleiman, Patrick M.A., Chiavacci, Rosetta, Annaiah, Kiran, Thomas, Kelly, Hou, Cuiping, Glaberson, Wendy, Flory, James, Otieno, Frederick, Garris, Maria, Soorya, Latha, Klei, Lambertus, Piven, Joseph, Meyer, Kacie J., Anagnostou, Evdokia, Sakurai, Takeshi, Game, Rachel M., Rudd, Danielle S., Zurawiecki, Danielle, McDouglelo, Christopher J., Davis, Lea K., Miller, Judith, Posey, David J., Michaels, Shana, Kolevzon, Alexander, Silverman, Jeremy M., Bernier, Raphael, Levy, Susan E., Schultz, Robert T., Dawson, Geraldine, Owleys, Thomas, McMahon, William M., Wassink, Thomas H., Sweeney, John A., Nurnberger, Jr., John I., Coon, Hilary, Sutcliffe, James S., Minshew, Nancy J., Grant, Struan F.A., Bucan, Maja, Cook, Jr., Edwin H., Buxbaum, Joseph D., Devlin, Bernie D., Schellenberg, Gerard D., and Hakonarson, Hakon
Subjects: Neurons -- Properties -- Genetic aspects, Ubiquitin -- Properties -- Genetic aspects, Autism -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Genetic aspects, Properties
Abstract: Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins(1-4). Previous studies focusing on candidate genes or genomic regions have identified several copy number variations (CNVs) that are associated with an increased risk of ASDs(5-9). Here we present the results from a whole-genome CNV study on a cohort of 859 ASD cases and 1,409 healthy children of European ancestry who were genotyped with 550,000 single nucleotide polymorphism markers, in an attempt to comprehensively identify CNVs conferring susceptibility to ASDs. Positive findings were evaluated in an independent cohort of 1,336 ASD cases and 1,110 controls of European ancestry. Besides previously reported ASD candidate genes, such as NRXNI (ref. 10) and CNTN4 (refs 11, 12), several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGNI and ASTN2, were enriched with CNVs in ASD cases compared to controls (P = 9.5 x [10.sup.-3]). Furthermore, CNVs within or surrounding genes involved in the ubiquitin pathways, including UBE3A, PARKZ RFWD2 and FBX040, were affected by CNVs not observed in controls (P= 3.3 x [10.sup.-3]). We also identified duplications 55 kilobases upstream of complementary DNA AK123120 (P=3.6 x [10.sup.-6]). Although these variants may be individually rare, they target genes involved in neuronal cell-adhesion or ubiquitin degradation, indicating that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD., ASDs, including autism, are neurodevelopmental disorders characterized by impairments in social and communication skills, as well as stereotyped and repetitive behaviours and/or a restricted range of interests. Current prevalence estimates [...]
Published: 2009

30. MTHFR 677C [right arrow] T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val [right arrow] Met

Author: Roffman, Joshua L., Gollub, Randy L., Calhoun, Vince D., Wassink, Thomas H., Weiss, Anthony P., Ho, Beng C., White, Tonya, Clark, Vincent P., Fries, Jill, Andreasen, Nancy C., Goff, Donald C., and Manoach, Dara S.
Subjects: Schizophrenia -- Complications and side effects, Schizophrenia -- Genetic aspects, Prefrontal cortex -- Genetic aspects, Prefrontal cortex -- Health aspects, Science and technology
Abstract: Understanding how risk genes cumulatively impair brain function in schizophrenia could provide critical insights into its pathophysiology. Working memory impairment in schizophrenia has been associated with abnormal dopamine signaling in the prefrontal cortex, which is likely under complex genetic control. The catechol-O-methyltransferase (COMT) 158Val [right arrow] Met polymorphism (rs4680), which affects the availability of prefrontal dopamine signaling, consistently stratifies prefrontal activation during working memory performance. However, the Iow-dopamine COMT 158Val allele does not confer increased risk for schizophrenia, and its effects on prefrontal function are not specific to the disorder. In the setting of other genetic variants influencing prefrontal dopamine signaling, COMT 158Val [right arrow] Met genotype may exert disease-specific effects. A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C [right arrow] T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects. We found that the hypofunctional 677T variant was associated with decreased working memory load-dependent activation in the prefrontal and insular cortices in 79 schizophrenia patients, but not in 75 demographically matched healthy controls. Further, significant MTHFR x COMT genotype interactions were observed, which differed by diagnostic group: Reduced prefrontal activation was associated with the 677T and 158Val alleles in patients, but with 677C/C and 158Met/Met genotype in controls. These findings are consistent with epistatic effects of the COMT and MTHFR polymorphisms on prefrontal dopamine signaling, and suggest that in schizophrenia patients, the MTHFR 677T allele exacerbates prefrontal dopamine deficiency. The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype. dopamine | folate | functional MRI | genetics | methylation
Published: 2008

31. Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism

Author: Wassink, Thomas H., Hazlett, Heather C., Epping, Eric A., Arndt, Stephan, Dager, Stephen R., Schellenberg, Gerard D., Dawson, Geraldine, and Piven, Joseph
Subjects: Autism -- Genetic aspects, Nerve tissue -- Genetic aspects, Nerve tissue -- Research, Genetic variation -- Analysis, Serotonin -- Genetic aspects, Serotonin -- Research, Health, Psychology and mental health
Published: 2007

32. A case of autism and uniparental disomy of chromosome 1

Author: Wassink, Thomas H., Losh, Molly, Frantz, Rebecca S., Vieland, Veronica J., Goedken, Rhinda, Piven, Joseph, and Sheffield, Val C.
Published: 2005
Full Text: View/download PDF

33. Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers

Author: Ho, Beng-Choon, Milev, Peter, O'Leary, Daniel S., Librant, Amy, Andreasen, Nancy C., and Wassink, Thomas H.
Subjects: Genetic polymorphisms -- Research, Schizophrenia -- Genetic aspects, Schizophrenia -- Research, Cognition disorders -- Research, Magnetic resonance imaging -- Usage, Health, Psychology and mental health
Published: 2006

34. The molecular genetics of autism

Author: Wassink, Thomas H. and Piven, Joseph
Published: 2000
Full Text: View/download PDF

35. Individual common variants exert weak effects on the risk for autism spectrum disorderspi

Author: Anney, Richard, Klei, Lambertus, Pinto, Dalila, Almeida, Joana, Bacchelli, Elena, Baird, Gillian, Bolshakova, Nadia, Bölte, Sven, Bolton, Patrick F., Bourgeron, Thomas, Brennan, Sean, Brian, Jessica, Casey, Jillian, Conroy, Judith, Correia, Catarina, Corsello, Christina, Crawford, Emily L., de Jonge, Maretha, Delorme, Richard, Duketis, Eftichia, Duque, Frederico, Estes, Annette, Farrar, Penny, Fernandez, Bridget A., Folstein, Susan E., Fombonne, Eric, Gilbert, John, Gillberg, Christopher, Glessner, Joseph T., Green, Andrew, Green, Jonathan, Guter, Stephen J., Heron, Elizabeth A., Holt, Richard, Howe, Jennifer L., Hughes, Gillian, Hus, Vanessa, Igliozzi, Roberta, Jacob, Suma, Kenny, Graham P., Kim, Cecilia, Kolevzon, Alexander, Kustanovich, Vlad, Lajonchere, Clara M., Lamb, Janine A., Law-Smith, Miriam, Leboyer, Marion, Le Couteur, Ann, Leventhal, Bennett L., Liu, Xiao-Qing, Lombard, Frances, Lord, Catherine, Lotspeich, Linda, Lund, Sabata C., Magalhaes, Tiago R., Mantoulan, Carine, McDougle, Christopher J., Melhem, Nadine M., Merikangas, Alison, Minshew, Nancy J., Mirza, Ghazala K., Munson, Jeff, Noakes, Carolyn, Nygren, Gudrun, Papanikolaou, Katerina, Pagnamenta, Alistair T., Parrini, Barbara, Paton, Tara, Pickles, Andrew, Posey, David J., Poustka, Fritz, Ragoussis, Jiannis, Regan, Regina, Roberts, Wendy, Roeder, Kathryn, Roge, Bernadette, Rutter, Michael L., Schlitt, Sabine, Shah, Naisha, Sheffield, Val C., Soorya, Latha, Sousa, Inês, Stoppioni, Vera, Sykes, Nuala, Tancredi, Raffaella, Thompson, Ann P., Thomson, Susanne, Tryfon, Ana, Tsiantis, John, Van Engeland, Herman, Vincent, John B., Volkmar, Fred, Vorstman, JAS, Wallace, Simon, Wing, Kirsty, Wittemeyer, Kerstin, Wood, Shawn, Zurawiecki, Danielle, Zwaigenbaum, Lonnie, Bailey, Anthony J., Battaglia, Agatino, Cantor, Rita M., Coon, Hilary, Cuccaro, Michael L., Dawson, Geraldine, Ennis, Sean, Freitag, Christine M., Geschwind, Daniel H., Haines, Jonathan L., Klauck, Sabine M., McMahon, William M., Maestrini, Elena, Miller, Judith, Monaco, Anthony P., Nelson, Stanley F., Nurnberger, John I., Jr., Oliveira, Guiomar, Parr, Jeremy R., Pericak-Vance, Margaret A., Piven, Joseph, Schellenberg, Gerard D., Scherer, Stephen W., Vicente, Astrid M., Wassink, Thomas H., Wijsman, Ellen M., Betancur, Catalina, Buxbaum, Joseph D., Cook, Edwin H., Gallagher, Louise, Gill, Michael, Hallmayer, Joachim, Paterson, Andrew D., Sutcliffe, James S., Szatmari, Peter, Vieland, Veronica J., Hakonarson, Hakon, and Devlin, Bernie
Published: 2012
Full Text: View/download PDF

36. Influence of ZNF804a on Brain Structure Volumes and Symptom Severity in Individuals With Schizophrenia

Author: Wassink, Thomas H., Epping, Eric A., Rudd, Danielle, Axelsen, Michael, Ziebell, Stephen, Fleming, Frank W., Monson, Eric, Ho, Beng Choon, and Andreasen, Nancy C.
Published: 2012
Full Text: View/download PDF

37. Copy number variations on chromosome 12q14 in patients with normal tension glaucoma

Author: Fingert, John H., Robin, Alan L., Stone, Jennifer L., Roos, Ben R., Davis, Lea K., Scheetz, Todd E., Bennett, Steve R., Wassink, Thomas H., Kwon, Young H., Alward, Wallace L.M., Mullins, Robert F., Sheffield, Val C., and Stone, Edwin M.
Published: 2011
Full Text: View/download PDF

38. Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

Author: Dima, Danai, primary, Papachristou, Efstathios, additional, Modabbernia, Amirhossein, additional, Doucet, Gaelle E, additional, Agartz, Ingrid, additional, Aghajani, Moji, additional, Akudjedu, Theophilus N, additional, Albajes-Eizagirre, Anton, additional, Alnæs, Dag, additional, Alpert, Kathryn I, additional, Andersson, Micael, additional, Andreasen, Nancy, additional, Andreassen, Ole A, additional, Asherson, Philip, additional, Banaschewski, Tobias, additional, Bargallo, Nuria, additional, Baumeister, Sarah, additional, Baur-Streubel, Ramona, additional, Bertolino, Alessandro, additional, Bonvino, Aurora, additional, Boomsma, Dorret I, additional, Borgwardt, Stefan, additional, Bourque, Josiane, additional, Brandeis, Daniel, additional, Breier, Alan, additional, Brodaty, Henry, additional, Brouwer, Rachel M, additional, Buitelaar, Jan K, additional, Busatto, Geraldo F, additional, Buckner, Randy L, additional, Calhoun, Vincent, additional, Canales-Rodríguez, Erick J, additional, Cannon, Dara M, additional, Caseras, Xavier, additional, Castellanos, Francisco X, additional, Cervenka, Simon, additional, Chaim-Avancini, Tiffany M, additional, Ching, Christopher RK, additional, Clark, Vincent P, additional, Conrod, Patricia, additional, Conzelmann, Annette, additional, Crespo-Facorro, Benedicto, additional, Crivello, Fabrice, additional, Crone, Eveline AM, additional, Dale, Anders M, additional, Davey, Cristopher, additional, de Geus, Eco JC, additional, de Haan, Lieuwe, additional, de Zubicaray, Greig I, additional, den Braber, Anouk, additional, Dickie, Erin W, additional, Di Giorgio, Annabella, additional, Doan, Nhat Trung, additional, Dørum, Erlend S, additional, Ehrlich, Stefan, additional, Erk, Susanne, additional, Espeseth, Thomas, additional, Fatouros-Bergman, Helena, additional, Fisher, Simon E, additional, Fouche, Jean-Paul, additional, Franke, Barbara, additional, Frodl, Thomas, additional, Fuentes-Claramonte, Paola, additional, Glahn, David C, additional, Gotlib, Ian H, additional, Grabe, Hans-Jörgen, additional, Grimm, Oliver, additional, Groenewold, Nynke A, additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Gruner, Patricia, additional, Gur, Rachel E, additional, Gur, Ruben C, additional, Harrison, Ben J, additional, Hartman, Catharine A, additional, Hatton, Sean N, additional, Heinz, Andreas, additional, Heslenfeld, Dirk J, additional, Hibar, Derrek P, additional, Hickie, Ian B, additional, Ho, Beng-Choon, additional, Hoekstra, Pieter J, additional, Hohmann, Sarah, additional, Holmes, Avram J, additional, Hoogman, Martine, additional, Hosten, Norbert, additional, Howells, Fleur M, additional, Hulshoff Pol, Hilleke E, additional, Huyser, Chaim, additional, Jahanshad, Neda, additional, James, Anthony, additional, Jiang, Jiyang, additional, Jönsson, Erik G, additional, Joska, John A, additional, Kahn, Rene, additional, Kalnin, Andrew, additional, Kanai, Ryota, additional, Kang, Sim, additional, Klein, Marieke, additional, Klushnik, Tatyana P, additional, Koenders, Laura, additional, Koops, Sanne, additional, Krämer, Bernd, additional, Kuntsi, Jonna, additional, Lagopoulos, Jim, additional, Lázaro, Luisa, additional, Lebedeva, Irina, additional, Lee, Won Hee, additional, Lesch, Klaus-Peter, additional, Lochner, Christine, additional, Machielsen, Marise WJ, additional, Maingault, Sophie, additional, Martin, Nicholas G, additional, Martínez-Zalacaín, Ignacio, additional, Mataix-Cols, David, additional, Mazoyer, Bernard, additional, McDonald, Colm, additional, McDonald, Brenna C, additional, McIntosh, Andrew M, additional, McMahon, Katie L, additional, McPhilemy, Genevieve, additional, Menchón, José M, additional, Medland, Sarah E, additional, Meyer-Lindenberg, Andreas, additional, Naaijen, Jilly, additional, Najt, Pablo, additional, Nakao, Tomohiro, additional, Nordvik, Jan E, additional, Nyberg, Lars, additional, Oosterlaan, Jaap, additional, de la Foz, Víctor Ortiz-García, additional, Paloyelis, Yannis, additional, Pauli, Paul, additional, Pergola, Giulio, additional, Pomarol-Clotet, Edith, additional, Portella, Maria J, additional, Potkin, Steven G, additional, Radua, Joaquim, additional, Reif, Andreas, additional, Roffman, Joshua L, additional, Rosa, Pedro GP, additional, Sacchet, Matthew D, additional, Sachdev, Perminder S, additional, Salvador, Raymond, additional, Sánchez-Juan, Pascual, additional, Sarró, Salvador, additional, Satterthwaite, Theodore D, additional, Saykin, Andrew J, additional, Serpa, Mauricio H, additional, Schmaal, Lianne, additional, Schnell, Knut, additional, Schumann, Gunter, additional, Smoller, Jordan W, additional, Sommer, Iris, additional, Soriano-Mas, Carles, additional, Stein, Dan J, additional, Strike, Lachlan T, additional, Swagerman, Suzanne C, additional, Tamnes, Christian K, additional, Temmingh, Henk S, additional, Thomopoulos, Sophia I, additional, Tomyshev, Alexander S, additional, Tordesillas-Gutiérrez, Diana, additional, Trollor, Julian N, additional, Turner, Jessica A, additional, Uhlmann, Anne, additional, van den Heuvel, Odille A, additional, van den Meer, Dennis, additional, van der Wee, Nic JA, additional, van Haren, Neeltje EM, additional, van ’t Ent, Dennis, additional, van Erp, Theo GM, additional, Veer, Ilya M, additional, Veltman, Dick J, additional, Völzke, Henry, additional, Walter, Henrik, additional, Walton, Esther, additional, Wang, Lei, additional, Wang, Yang, additional, Wassink, Thomas H, additional, Weber, Bernd, additional, Wen, Wei, additional, West, John D, additional, Westlye, Lars T, additional, Whalley, Heather, additional, Wierenga, Lara M, additional, Williams, Steven CR, additional, Wittfeld, Katharina, additional, Wolf, Daniel H, additional, Worker, Amanda, additional, Wright, Margaret J, additional, Yang, Kun, additional, Yoncheva, Yulyia, additional, Zanetti, Marcus V, additional, Ziegler, Georg C, additional, Thompson, Paul M, additional, and Frangou, Sophia, additional
Published: 2020
Full Text: View/download PDF

39. Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

Author: Frangou, Sophia, primary, Modabbernia, Amirhossein, additional, Doucet, Gaelle E, additional, Papachristou, Efstathios, additional, Williams, Steven CR, additional, Agartz, Ingrid, additional, Aghajani, Moji, additional, Akudjedu, Theophilus N, additional, Albajes-Eizagirre, Anton, additional, Alnæs, Dag, additional, Alpert, Kathryn I, additional, Andersson, Micael, additional, Andreasen, Nancy, additional, Andreassen, Ole A, additional, Asherson, Philip, additional, Banaschewski, Tobias, additional, Bargallo, Nuria, additional, Baumeister, Sarah, additional, Baur-Streubel, Ramona, additional, Bertolino, Alessandro, additional, Bonvino, Aurora, additional, Boomsma, Dorret I, additional, Borgwardt, Stefan, additional, Bourque, Josiane, additional, Brandeis, Daniel, additional, Breier, Alan, additional, Brodaty, Henry, additional, Brouwer, Rachel M, additional, Buitelaar, Jan K, additional, Busatto, Geraldo F, additional, Buckner, Randy L, additional, Calhoun, Vincent, additional, Canales-Rodríguez, Erick J, additional, Cannon, Dara M, additional, Caseras, Xavier, additional, Castellanos, Francisco X, additional, Cervenka, Simon, additional, Chaim-Avancini, Tiffany M, additional, Ching, Christopher RK, additional, Clark, Vincent P, additional, Conrod, Patricia, additional, Conzelmann, Annette, additional, Crespo-Facorro, Benedicto, additional, Crivello, Fabrice, additional, Crone, Eveline AM, additional, Dale, Anders M, additional, Davey, Cristopher, additional, de Geus, Eco JC, additional, de Haan, Lieuwe, additional, de Zubicaray, Greig I, additional, Braber, Anouk den, additional, Dickie, Erin W, additional, Di Giorgio, Annabella, additional, Doan, Nhat Trung, additional, Dørum, Erlend S, additional, Ehrlich, Stefan, additional, Erk, Susanne, additional, Espeseth, Thomas, additional, Fatouros-Bergman, Helena, additional, Fisher, Simon E, additional, Fouche, Jean-Paul, additional, Franke, Barbara, additional, Frodl, Thomas, additional, Fuentes-Claramonte, Paola, additional, Glahn, David C, additional, Gotlib, Ian H, additional, Grabe, Hans-Jörgen, additional, Grimm, Oliver, additional, Groenewold, Nynke A, additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Gruner, Patricia, additional, Gur, Rachel E, additional, Gur, Ruben C, additional, Harrison, Ben J, additional, Hartman, Catharine A, additional, Hatton, Sean N, additional, Heinz, Andreas, additional, Heslenfeld, Dirk J, additional, Hibar, Derrek P, additional, Hickie, Ian B, additional, Ho, Beng-Choon, additional, Hoekstra, Pieter J, additional, Hohmann, Sarah, additional, Holmes, Avram J, additional, Hoogman, Martine, additional, Hosten, Norbert, additional, Howells, Fleur M, additional, Hulshoff Pol, Hilleke E, additional, Huyser, Chaim, additional, Jahanshad, Neda, additional, James, Anthony, additional, Jiang, Jiyang, additional, Jönsson, Erik G, additional, Joska, John A, additional, Kahn, Rene, additional, Kalnin, Andrew, additional, Kanai, Ryota, additional, Kang, Sim, additional, Klein, Marieke, additional, Klushnik, Tatyana P, additional, Koenders, Laura, additional, Koops, Sanne, additional, Krämer, Bernd, additional, Kuntsi, Jonna, additional, Lagopoulos, Jim, additional, Lázaro, Luisa, additional, Lebedeva, Irina, additional, Lee, Won Hee, additional, Lesch, Klaus-Peter, additional, Lochner, Christine, additional, Machielsen, Marise WJ, additional, Maingault, Sophie, additional, Martin, Nicholas G, additional, Martínez-Zalacaín, Ignacio, additional, Mataix-Cols, David, additional, Mazoyer, Bernard, additional, McDonald, Colm, additional, McDonald, Brenna C, additional, McIntosh, Andrew M, additional, McMahon, Katie L, additional, McPhilemy, Genevieve, additional, Menchón, José M, additional, Medland, Sarah E, additional, Meyer-Lindenberg, Andreas, additional, Naaijen, Jilly, additional, Najt, Pablo, additional, Nakao, Tomohiro, additional, Nordvik, Jan E, additional, Nyberg, Lars, additional, Oosterlaan, Jaap, additional, de la Foz, Víctor Ortiz-García, additional, Paloyelis, Yannis, additional, Pauli, Paul, additional, Pergola, Giulio, additional, Pomarol-Clotet, Edith, additional, Portella, Maria J, additional, Potkin, Steven G, additional, Radua, Joaquim, additional, Reif, Andreas, additional, Roffman, Joshua L, additional, Rosa, Pedro GP, additional, Sacchet, Matthew D, additional, Sachdev, Perminder S, additional, Salvador, Raymond, additional, Sánchez-Juan, Pascual, additional, Sarró, Salvador, additional, Satterthwaite, Theodore D, additional, Saykin, Andrew J, additional, Serpa, Mauricio H, additional, Schmaal, Lianne, additional, Schnell, Knut, additional, Schumann, Gunter, additional, Smoller, Jordan W, additional, Sommer, Iris, additional, Soriano-Mas, Carles, additional, Stein, Dan J, additional, Strike, Lachlan T, additional, Swagerman, Suzanne C, additional, Tamnes, Christian K, additional, Temmingh, Henk S, additional, Thomopoulos, Sophia I, additional, Tomyshev, Alexander S, additional, Tordesillas-Gutiérrez, Diana, additional, Trollor, Julian N, additional, Turner, Jessica A, additional, Uhlmann, Anne, additional, van den Heuvel, Odille A, additional, van den Meer, Dennis, additional, van der Wee, Nic JA, additional, van Haren, Neeltje EM, additional, van ’t Ent, Dennis, additional, van Erp, Theo GM, additional, Veer, Ilya M, additional, Veltman, Dick J, additional, Völzke, Henry, additional, Walter, Henrik, additional, Walton, Esther, additional, Wang, Lei, additional, Wang, Yang, additional, Wassink, Thomas H, additional, Weber, Bernd, additional, Wen, Wei, additional, West, John D, additional, Westlye, Lars T, additional, Whalley, Heather, additional, Wierenga, Lara M, additional, Wittfeld, Katharina, additional, Wolf, Daniel H, additional, Wright, Margaret J, additional, Yang, Kun, additional, Yoncheva, Yulyia, additional, Zanetti, Marcus V, additional, Ziegler, Georg C, additional, Thompson, Paul M, additional, and Dima, Danai, additional
Published: 2020
Full Text: View/download PDF

40. A genome-wide scan for common alleles affecting risk for autism

Author: Anney, Richard, Klei, Lambertus, Pinto, Dalila, Regan, Regina, Conroy, Judith, Magalhaes, Tiago R., Correia, Catarina, Abrahams, Brett S., Sykes, Nuala, Pagnamenta, Alistair T., Almeida, Joana, Bacchelli, Elena, Bailey, Anthony J., Baird, Gillian, Battaglia, Agatino, Berney, Tom, Bolshakova, Nadia, Bölte, Sven, Bolton, Patrick F., Bourgeron, Thomas, Brennan, Sean, Brian, Jessica, Carson, Andrew R., Casallo, Guillermo, Casey, Jillian, Chu, Su H., Cochrane, Lynne, Corsello, Christina, Crawford, Emily L., Crossett, Andrew, Dawson, Geraldine, de Jonge, Maretha, Delorme, Richard, Drmic, Irene, Duketis, Eftichia, Duque, Frederico, Estes, Annette, Farrar, Penny, Fernandez, Bridget A., Folstein, Susan E., Fombonne, Eric, Freitag, Christine M., Gilbert, John, Gillberg, Christopher, Glessner, Joseph T., Goldberg, Jeremy, Green, Jonathan, Guter, Stephen J., Hakonarson, Hakon, Heron, Elizabeth A., Hill, Matthew, Holt, Richard, Howe, Jennifer L., Hughes, Gillian, Hus, Vanessa, Igliozzi, Roberta, Kim, Cecilia, Klauck, Sabine M., Kolevzon, Alexander, Korvatska, Olena, Kustanovich, Vlad, Lajonchere, Clara M., Lamb, Janine A., Laskawiec, Magdalena, Leboyer, Marion, Le Couteur, Ann, Leventhal, Bennett L., Lionel, Anath C., Liu, Xiao-Qing, Lord, Catherine, Lotspeich, Linda, Lund, Sabata C., Maestrini, Elena, Mahoney, William, Mantoulan, Carine, Marshall, Christian R., McConachie, Helen, McDougle, Christopher J., McGrath, Jane, McMahon, William M., Melhem, Nadine M., Merikangas, Alison, Migita, Ohsuke, Minshew, Nancy J., Mirza, Ghazala K., Munson, Jeff, Nelson, Stanley F., Noakes, Carolyn, Noor, Abdul, Nygren, Gudrun, Oliveira, Guiomar, Papanikolaou, Katerina, Parr, Jeremy R., Parrini, Barbara, Paton, Tara, Pickles, Andrew, Piven, Joseph, Posey, David J, Poustka, Annemarie, Poustka, Fritz, Prasad, Aparna, Ragoussis, Jiannis, Renshaw, Katy, Rickaby, Jessica, Roberts, Wendy, Roeder, Kathryn, Roge, Bernadette, Rutter, Michael L., Bierut, Laura J., Rice, John P., Salt, Jeff, Sansom, Katherine, Sato, Daisuke, Segurado, Ricardo, Senman, Lili, Shah, Naisha, Sheffield, Val C., Soorya, Latha, Sousa, Inês, Stoppioni, Vera, Strawbridge, Christina, Tancredi, Raffaella, Tansey, Katherine, Thiruvahindrapduram, Bhooma, Thompson, Ann P., Thomson, Susanne, Tryfon, Ana, Tsiantis, John, Van Engeland, Herman, Vincent, John B., Volkmar, Fred, Wallace, Simon, Wang, Kai, Wang, Zhouzhi, Wassink, Thomas H., Wing, Kirsty, Wittemeyer, Kerstin, Wood, Shawn, Yaspan, Brian L., Zurawiecki, Danielle, Zwaigenbaum, Lonnie, Betancur, Catalina, Buxbaum, Joseph D., Cantor, Rita M., Cook, Edwin H., Coon, Hilary, Cuccaro, Michael L., Gallagher, Louise, Geschwind, Daniel H., Gill, Michael, Haines, Jonathan L., Miller, Judith, Monaco, Anthony P., Nurnberger, John I., Jr., Paterson, Andrew D., Pericak-Vance, Margaret A., Schellenberg, Gerard D., Scherer, Stephen W., Sutcliffe, James S., Szatmari, Peter, Vicente, Astrid M., Vieland, Veronica J., Wijsman, Ellen M., Devlin, Bernie, Ennis, Sean, and Hallmayer, Joachim
Published: 2010
Full Text: View/download PDF

41. Functional impact of global rare copy number variation in autism spectrum disorders

Author: Pinto, Dalila, Pagnamenta, Alistair T., Klei, Lambertus, Anney, Richard, Merico, Daniele, Regan, Regina, Conroy, Judith, Magalhaes, Tiago R., Correia, Catarina, Abrahams, Brett S., Almeida, Joana, Bacchelli, Elena, Bader, Gary D., Bailey, Anthony J., Baird, Gillian, Battaglia, Agatino, Berney, Tom, Bolshakova, Nadia, Bölte, Sven, Bolton, Patrick F., Bourgeron, Thomas, Brennan, Sean, Brian, Jessica, Bryson, Susan E., Carson, Andrew R., Casallo, Guillermo, Casey, Jillian, Chung, Brian H.Y., Cochrane, Lynne, Corsello, Christina, Crawford, Emily L., Crossett, Andrew, Cytrynbaum, Cheryl, Dawson, Geraldine, de Jonge, Maretha, Delorme, Richard, Drmic, Irene, Duketis, Eftichia, Duque, Frederico, Estes, Annette, Farrar, Penny, Fernandez, Bridget A., Folstein, Susan E., Fombonne, Eric, Freitag, Christine M., Gilbert, John, Gillberg, Christopher, Glessner, Joseph T., Goldberg, Jeremy, Green, Andrew, Green, Jonathan, Guter, Stephen J., Hakonarson, Hakon, Heron, Elizabeth A., Hill, Matthew, Holt, Richard, Howe, Jennifer L., Hughes, Gillian, Hus, Vanessa, Igliozzi, Roberta, Kim, Cecilia, Klauck, Sabine M., Kolevzon, Alexander, Korvatska, Olena, Kustanovich, Vlad, Lajonchere, Clara M., Lamb, Janine A., Laskawiec, Magdalena, Leboyer, Marion, Le Couteur, Ann, Leventhal, Bennett L., Lionel, Anath C., Liu, Xiao-Qing, Lord, Catherine, Lotspeich, Linda, Lund, Sabata C., Maestrini, Elena, Mahoney, William, Mantoulan, Carine, Marshall, Christian R., McConachie, Helen, McDougle, Christopher J., McGrath, Jane, McMahon, William M., Merikangas, Alison, Migita, Ohsuke, Minshew, Nancy J., Mirza, Ghazala K., Munson, Jeff, Nelson, Stanley F., Noakes, Carolyn, Noor, Abdul, Nygren, Gudrun, Oliveira, Guiomar, Papanikolaou, Katerina, Parr, Jeremy R., Parrini, Barbara, Paton, Tara, Pickles, Andrew, Pilorge, Marion, Piven, Joseph, Ponting, Chris P., Posey, David J., Poustka, Annemarie, Poustka, Fritz, Prasad, Aparna, Ragoussis, Jiannis, Renshaw, Katy, Rickaby, Jessica, Roberts, Wendy, Roeder, Kathryn, Roge, Bernadette, Rutter, Michael L., Bierut, Laura J., Rice, John P., Salt, Jeff, Sansom, Katherine, Sato, Daisuke, Segurado, Ricardo, Sequeira, Ana F., Senman, Lili, Shah, Naisha, Sheffield, Val C., Soorya, Latha, Sousa, Inês, Stein, Olaf, Sykes, Nuala, Stoppioni, Vera, Strawbridge, Christina, Tancredi, Raffaella, Tansey, Katherine, Thiruvahindrapduram, Bhooma, Thompson, Ann P., Thomson, Susanne, Tryfon, Ana, Tsiantis, John, Van Engeland, Herman, Vincent, John B., Volkmar, Fred, Wallace, Simon, Wang, Kai, Wang, Zhouzhi, Wassink, Thomas H., Webber, Caleb, Weksberg, Rosanna, Wing, Kirsty, Wittemeyer, Kerstin, Wood, Shawn, Wu, Jing, Yaspan, Brian L., Zurawiecki, Danielle, Zwaigenbaum, Lonnie, Buxbaum, Joseph D., Cantor, Rita M., Cook, Edwin H., Coon, Hilary, Cuccaro, Michael L., Devlin, Bernie, Ennis, Sean, Gallagher, Louise, Geschwind, Daniel H., Gill, Michael, Haines, Jonathan L., Hallmayer, Joachim, Miller, Judith, Monaco, Anthony P., Nurnberger, John I., Jr, Paterson, Andrew D., Pericak-Vance, Margaret A., Schellenberg, Gerard D., Szatmari, Peter, Vicente, Astrid M., Vieland, Veronica J., Wijsman, Ellen M., Scherer, Stephen W., Sutcliffe, James S., and Betancur, Catalina
Published: 2010
Full Text: View/download PDF

42. A genome-wide linkage and association scan reveals novel loci for autism

Author: Weiss, Lauren A., Arking, Dan E., Daly, Mark J., Chakravarti, Aravinda, Brune, Camille W., West, Kristen, O’Connor, Ashley, Hilton, Gina, Tomlinson, Rebecca L., West, Andrew B., Cook, Edwin H., Jr, Green, Todd, Chang, Shun-Chiao, Gabriel, Stacey, Gates, Casey, Hanson, Ellen M., Kirby, Andrew, Korn, Joshua, Kuruvilla, Finny, McCarroll, Steven, Morrow, Eric M., Neale, Benjamin, Purcell, Shaun, Sasanfar, Roksana, Sougnez, Carrie, Stevens, Christine, Altshuler, David, Gusella, James, Santangelo, Susan L., Sklar, Pamela, Tanzi, Rudolph, Anney, Richard, Bailey, Anthony J., Baird, Gillian, Battaglia, Agatino, Berney, Tom, Betancur, Catalina, Bölte, Sven, Bolton, Patrick F., Brian, Jessica, Bryson, Susan E., Buxbaum, Joseph D., Cabrito, Ines, Cai, Guiqing, Cantor, Rita M., Coon, Hilary, Conroy, Judith, Correia, Catarina, Corsello, Christina, Crawford, Emily L., Cuccaro, Michael L., Dawson, Geraldine, de Jonge, Maretha, Devlin, Bernie, Duketis, Eftichia, Ennis, Sean, Estes, Annette, Farrar, Penny, Fombonne, Eric, Freitag, Christine M., Gallagher, Louise, Geschwind, Daniel H., Gilbert, John, Gill, Michael, Gillberg, Christopher, Goldberg, Jeremy, Green, Andrew, Green, Jonathan, Guter, Stephen J., Haines, Jonathan L., Hallmayer, Joachim F., Hus, Vanessa, Klauck, Sabine M., Korvatska, Olena, Lamb, Janine A., Laskawiec, Magdalena, Leboyer, Marion, Le Couteur, Ann, Leventhal, Bennett L., Liu, Xiao-Qing, Lord, Catherine, Lotspeich, Linda J., Maestrini, Elena, Magalhaes, Tiago, Mahoney, William, Mantoulan, Carine, McConachie, Helen, McDougle, Christopher J., McMahon, William M., Marshall, Christian R., Miller, Judith, Minshew, Nancy J., Monaco, Anthony P., Munson, Jeff, Nurnberger, John I., Jr, Oliveira, Guiomar, Pagnamenta, Alistair, Papanikolaou, Katerina, Parr, Jeremy R., Paterson, Andrew D., Pericak-Vance, Margaret A., Pickles, Andrew, Pinto, Dalila, Piven, Joseph, Posey, David J., Poustka, Annemarie, Poustka, Fritz, Regan, Regina, Reichert, Jennifer, Renshaw, Katy, Roberts, Wendy, Roge, Bernadette, Rutter, Michael L., Salt, Jeff, Schellenberg, Gerard D., Scherer, Stephen W., Sheffield, Val, Sutcliffe, James S., Szatmari, Peter, Tansey, Katherine, Thompson, Ann P., Tsiantis, John, Van Engeland, Herman, Vicente, Astrid M., Vieland, Veronica J., Volkmar, Fred, Wallace, Simon, Wassink, Thomas H., Wijsman, Ellen M., Wing, Kirsty, Wittemeyer, Kerstin, Yaspan, Brian L., Zwaigenbaum, Lonnie, Yoo, Seung-Yun, Sean Hill, Robert, Mukaddes, Nahit M., Balkhy, Soher, Gascon, Generoso, Al-Saad, Samira, Hashmi, Asif, Ware, Janice, Joseph, Robert M., LeClair, Elaine, Partlow, Jennifer N., Barry, Brenda, Walsh, Christopher A., Pauls, David, Moilanen, Irma, Ebeling, Hanna, Mattila, Marja-Leena, Kuusikko, Sanna, Jussila, Katja, Ignatius, Jaakko, Tolouei, Ala, Ghadami, Majid, Rostami, Maryam, Hosseinipour, Azam, Valujerdi, Maryam, Andresen, Kara, Winkloski, Brian, Haddad, Stephen, Kunkel, Lou, Kohane, Zak, Tran, Tram, Won Kong, Sek, O’Neil, Stephanie Brewster, Hundley, Rachel, Holm, Ingrid, Peters, Heather, Baroni, Elizabeth, Cangialose, Aislyn, Jackson, Lindsay, Albers, Lisa, Becker, Ronald, Bridgemohan, Carolyn, Friedman, Sandra, Munir, Kerim, Nazir, Ramzi, Palfrey, Judith, Schonwald, Alison, Simmons, Esau, Rappaport, Leonard A., Gauthier, Julie, Mottron, Laurent, Joober, Ridha, Rouleau, Guy, Rehnstrom, Karola, von Wendt, Lennart, and Peltonen, Leena
Published: 2009
Full Text: View/download PDF

43. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

Author: Glessner, Joseph T., Wang, Kai, Cai, Guiqing, Korvatska, Olena, Kim, Cecilia E., Wood, Shawn, Zhang, Haitao, Estes, Annette, Brune, Camille W., Bradfield, Jonathan P., Imielinski, Marcin, Frackelton, Edward C., Reichert, Jennifer, Crawford, Emily L., Munson, Jeffrey, Sleiman, Patrick M. A., Chiavacci, Rosetta, Annaiah, Kiran, Thomas, Kelly, Hou, Cuiping, Glaberson, Wendy, Flory, James, Otieno, Frederick, Garris, Maria, Soorya, Latha, Klei, Lambertus, Piven, Joseph, Meyer, Kacie J., Anagnostou, Evdokia, Sakurai, Takeshi, Game, Rachel M., Rudd, Danielle S., Zurawiecki, Danielle, McDougle, Christopher J., Davis, Lea K., Miller, Judith, Posey, David J., Michaels, Shana, Kolevzon, Alexander, Silverman, Jeremy M., Bernier, Raphael, Levy, Susan E., Schultz, Robert T., Dawson, Geraldine, Owley, Thomas, McMahon, William M., Wassink, Thomas H., Sweeney, John A., Nurnberger, John I., Coon, Hilary, Sutcliffe, James S., Minshew, Nancy J., Grant, Struan F. A., Bucan, Maja, Cook, Edwin H., Buxbaum, Joseph D., Devlin, Bernie, Schellenberg, Gerard D., and Hakonarson, Hakon
Published: 2009
Full Text: View/download PDF

44. Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa

Author: Walton, E, Hibar, D, Yilmaz, Z, Jahanshad, N, Cheung, J, Batury, V-L, Seitz, J, Bulik, CM, Thompson, PM, Ehrlich, Stefan, Hibar, Derrek P, Stein, Jason L, Renteria, Miguel E, Arias-Vasquez, Alejandro, Desrivieres, Sylvane, Jahanshad, Neda, Toro, Roberto, Wittfeld, Katharina, Abramovic, Lucija, Andersson, Micael, Aribisala, Benjamin S, Armstrong, Nicola J, Bernard, Manon, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brown, Andrew A, Chakravarty, M Mallar, Chen, Qiang, Ching, Christopher RK, Cuellar-Partida, Gabriel, Den Braber, Anouk, Giddaluru, Sudheer, Goldman, Aaron L, Grimm, Oliver, Guadalupe, Tulio, Hass, Johanna, Woldehawariat, Girma, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Loohuis, Loes M Olde, Luciano, Michelle, Macare, Christine, Mather, Karen A, Mattheisen, Manuel, Milaneschi, Yuri, Nho, Kwangsik, Papmeyer, Martina, Ramasamy, Adaikalavan, Risacher, Shannon L, Roiz-Santianez, Roberto, Rose, Emma J, Salami, Alireza, Samann, Philipp G, Schmaal, Lianne, Schork, Andrew J, Shin, Jean, Strike, Lachlan T, Teumer, Alexander, van Donkelaar, Marjolein MJ, van Eijk, Kristel R, Walters, Raymond K, Westlye, Lars T, Whelan, Christopher D, Winkler, Anderson M, Zwiers, Marcel P, Alhusaini, Saud, Athanasiu, Lavinia, Hakobjan, Marina MH, Hartberg, Cecilie B, Haukvik, Unn K, Heister, Angelien JGAM, Hohn, David, Kasperaviciute, Dalia, Liewald, David CM, Lopez, Lorna M, Makkinje, Remco RR, Matarin, Mar, Naber, Marlies AM, Mckay, David R, Needham, Margaret, Nugent, Allison C, Putz, Benno, Shen, Li, Sprooten, Emma, Trabzuni, Daniah, van der Marel, Saskia SL, van Hulzen, Kimm JE, Walton, Esther, Wolf, Christiane, Almasy, Laura, Ames, David, Arepalli, Sampath, Assareh, Amelia A, Bastin, Mark E, Brodaty, Henry, Bulayeva, Kazima B, Carless, Melanie A, Cichon, Sven, Corvin, Aiden, Curran, Joanne E, Czisch, Michael, de Zubicaray, Greig I, Dillman, Allissa, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Fedko, Iryna O, Ferrucci, Luigi, Foroud, Tatiana M, Fox, Peter T, Fukunaga, Masaki, Gibbs, J Raphael, Goring, Harald HH, Green, Robert C, Guelfi, Sebastian, Hansell, Narelle K, Hartman, Catharina A, Hegenscheid, Katrin, Heinz, Andreas, Hernandez, Dena G, Heslenfeld, Dirk J, Hoekstra, Pieter J, Holsboer, Florian, Homuth, Georg, Hottenga, Jouke-Jan, Ikeda, Masashi, Jr, Jack Clifford R, Jenkinson, Mark, Johnson, Robert, Kanai, Ryota, Keil, Maria, Jr, Kent Jack W, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Liu, Xinmin, Longo, Dan L, McMahon, Katie L, Meisenzahl, Eva, Melle, Ingrid, Mohnke, Sebastian, Montgomery, Grant W, Mostert, Jeanette C, Muhleisen, Thomas W, Nalls, Michael A, Nichols, Thomas E, Nilsson, Lars G, Nothen, Markus M, Ohi, Kazutaka, Olvera, Rene L, Perez-Iglesias, Rocio, Pike, G Bruce, Potkin, Steven G, Reinvang, Ivar, Reppermund, Simone, Rietschel, Marcella, Romanczuk-Seiferth, Nina, Rosen, Glenn D, Rujescu, Dan, Schnell, Knut, Schofield, Peter R, Smith, Colin, Steen, Vidar M, Sussmann, Jessika E, Thalamuthu, Anbupalam, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Hernandez, Maria C Valdes, van't Ent, Dennis, van der Brug, Marcel, van der Wee, Nic JA, van Tol, Marie-Jose, Veltman, Dick J, Wassink, Thomas H, Westman, Eric, Zielke, Ronald H, Zonderman, Alan B, Ashbrook, David G, Hager, Reinmar, Lu, Lu, McMahon, Francis J, Morris, Derek W, Williams, Robert W, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Cahn, Wiepke, Calhoun, Vince D, Cavalleri, Gianpiero L, Crespo-Facorro, Benedicto, Dale, Anders M, Davies, Gareth E, Delanty, Norman, Depondt, Chantal, Djurovic, Srdjan, Drevets, Wayne C, Espeseth, Thomas, Gollub, Randy L, Ho, Beng-Choon, Hoffmann, Wolfgang, Hosten, Norbert, Kahn, Rene S, Le Hellard, Stephanie, Meyer-Lindenberg, Andreas, Mueller-Myhsok, Bertram, Nauck, Matthias, Nyberg, Lars, Pandolfo, Massimo, Penninx, Brenda WJH, Roffman, Joshua L, Sisodiya, Sanjay M, Smoller, Jordan W, van Bokhoven, Hans, van Haren, Neeltje EM, Volzke, Henry, Walter, Henrik, Weiner, Michael W, Wen, Wei, White, Tonya, Agartz, Ingrid, Andreassen, Ole A, Blangero, John, Boomsma, Dorret I, Brouwer, Rachel M, Cannon, Dara M, Cookson, Mark R, de Geus, Eco JC, Deary, Ian J, Donohoe, Gary, Fernandez, Guillen, Fisher, Simon E, Francks, Clyde, Glahn, David C, Grabe, Hans J, Gruber, Oliver, Hardy, John, Hashimoto, Ryota, Pol, Hilleke E Hulshoff, Jonsson, Erik G, Kloszewska, Iwona, Lovestone, Simon, Mattay, Venkata S, Mecocci, Patrizia, McDonald, Colm, McIntosh, Andrew M, Ophoff, Roel A, Paus, Tomas, Pausova, Zdenka, Ryten, Mina, Sachdev, Perminder S, Saykin, Andrew J, Simmons, Andrew, Singleton, Andrew, Soininen, Hilkka, Wardlaw, Joanna M, Weale, Michael E, Weinberger, Daniel R, Adams, Hieab HH, Launer, Lenore J, Seiler, Stephan, Schmidt, Reinhold, Chauhan, Ganesh, Satizabal, Claudia L, Becker, James T, Yanek, Lisa R, van der Lee, Sven J, Ebling, Maritza, Fischl, Bruce, Longstreth, WT, Greve, Douglas, Schmidt, Helena, Nyquist, Paul, Vinke, Louis N, van Duijn, Cornelia M, Luting, Xue, Mazoyer, Bernard, Bis, Joshua C, Gudnason, Vilmundur, Seshadri, Sudha, Ikram, M Arfan, Martin, Nicholas G, Wright, Margaret J, Schumann, Gunter, Franke, Barbara, Thompson, Paul M, Medland, Sarah E, Duncan, Laramie, Yilmaz, Zeynep, Walters, Raymond, Goldstein, Jackie, Anttila, Verneri, Bulik-Sullivan, Brendan, Ripke, Stephan, Adan, Roger, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole, Aschauer, Harald, Baker, Jessica, Barrett, Jeffrey, Bencko, Vladimir, Bergen, Andrew, Berrettini, Wade, Birgegard, Andreas, Boni, Claudette, Perica, Vesna Boraska, Brandt, Harry, Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Cichon, Carolyn Cesta Sven, Clementi, Maurizio, Cohen-Woods, Sarah, Coleman, Joni, Cone, Roger, Courtet, Philippe, Crawford, Steven, Crow, Scott, Crowley, Jim, Danner, Unna, Davis, Oliver, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece, Dick, Danielle, Dikeos, Dimitris, Dina, Christian, Ding, Bo, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Egberts, Karin, Escaramis, Georgia, Esko, Tonu, Estivill, Xavier, Favaro, Angela, Fernandez-Aranda, Fernando, Fichter, Manfred, Finan, Chris, Fischer, Krista, Floyd, James, Focker, Manuel, Foretova, Lenka, Forzan, Monica, Fox, Caroline, Franklin, Christopher, Gallinger, Valerie Gaborieau Steven, Gambaro, Giovanni, Gaspar, Helena, Giegling, Ina, Gonidakis, Fragiskos, Gorwood, Philip, Gratacos, Monica, Guillaume, Sebastien, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine, Harrison, Rebecca, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske, Hendriks, Judith, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hilliard, Christopher, Huckins, Laura, Hudson, James, Huemer, Julia, Imgart, Hartmut, Inoko, Hidetoshi, Jamain, Sigrid Jall Stephane, Janout, Vladimir, Jimenez-Murcia, Susana, Johnson, Craig, Jordan, Jenny, Julia, Antonio, Jureus, Anders, Kalsi, Gursharan, Kaplan, Allan, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andreas, Kas, Martien, Kaye, Walter, Kennedy, Martin, Kennedy, James, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klareskog, Lars, Klump, Kelly, Knudsen, Gun Peggy, Koeleman, Bobby, Koubek, Doris, La Via, Maria, Landen, Mikael, Leboyer, Marion, Levitan, Robert, Li, Dong, Lichtenstein, Paul, Lilenfeld, Lisa, Lissowska, Jolanta, Lundervold, Astri, Magistretti, Pierre, Maj, Mario, Mannik, Katrin, Marsal, Sara, Kaminska, Debora, Martin, Nicholas, Mattingsdal, Morten, McDevitt, Sara, McGuffin, Peter, Merl, Elisabeth, Metspalu, Andres, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, James, Mitchell, Karen, Monteleone, Palmiero, Monteleone, Alessio Maria, Montgomery, Grant, Mortensen, Preben, Munn-Chernoff, Melissa, Mueller, Timo, Nacmias, Benedetta, Navratilova, Marie, Nilsson, Ida, Norring, Claes, Ntalla, Ioanna, Ophoff, Roel, O'Toole, Julie, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Pinto, Richard Parker Dalila, Rabionet, Raquel, Raevuori, Anu, Rajewski, Andrzej, Ramoz, Nicolas, Rayner, N William, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rybakowski, Filip, Santonastaso, Paolo, Scherag, Andre, Scherer, Stephen, Schmidt, Ulrike, Schork, Nicholas, Schosser, Alexandra, Scott, Laura, Seitz, Jochen, Slachtova, Lenka, Sladek, Robert, Slagboom, P Eline, Slof-Op't Landt, Margarita, Slopien, Agnieszka, Smith, Tosha, Soranzo, Nicole, Sorbi, Sandro, Southam, Lorraine, Steen, Vidar, Strengman, Eric, Strober, Michael, Szatkiewicz, Jin, Szeszenia-Dabrowska, Neonila, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tschop, Matthias, Tsitsika, Artemis, Tziouvas, Konstantinos, van Elburg, Annemarie, van Furth, Eric, Wade, Tracey, Wagner, Gudrun, Watson, Hunna, Wichmann, H-Erich, Widen, Elisabeth, Woodside, D Blake, Yanovski, Jack, Yao, Shuyang, Zerwas, Stephanie, Zipfel, Stephan, Thornton, Laura, Hinney, Anke, Breen, Gerome, Bulik, Cynthia M, PGC-ED, Grp, ENIGMA Genetics Working, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Kas lab, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, and APH - Mental Health
Subjects: 0301 basic medicine, Anorexia Nervosa, Eating Disorders, REWARD CIRCUITRY, Genome-wide association study, ADOLESCENT, PGC-ED, Bioinformatics, Linkage Disequilibrium, 0302 clinical medicine, Anorexia nervosa, Brain structure, Genetic correlation, SCHIZOPHRENIA, ENIGMA Genetics Working Group, 2.1 Biological and endogenous factors, Psychology, Aetiology, Cervell, RISK, ABNORMALITIES, Anorèxia nerviosa, Brain, FUNCTIONAL CONNECTIVITY, Organ Size, Single Nucleotide, Serious Mental Illness, Magnetic Resonance Imaging, 3. Good health, Anorexia, Mental Health, Neurology, Anorexia nervosa (differential diagnoses), Brain size, MENDELIAN RANDOMIZATION, Biomedical Imaging, Cognitive Sciences, RESPONSE-INHIBITION, Neuroscience (miscellaneous), Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Mendelian randomization, Journal Article, Genetics, Humans, Genetic Testing, GENOME-WIDE ASSOCIATION, Polymorphism, POLYMORPHISMS, Genetic association, Neurology & Neurosurgery, Prevention, Human Genome, Neurosciences, Mendelian Randomization Analysis, Genetic architecture, Brain Disorders, 030104 developmental biology, Genetic marker, Case-Control Studies, 030217 neurology & neurosurgery, Genètica, Genome-Wide Association Study
Abstract: Molecular neurobiology 56(7), 5146-5156 (2019). doi:10.1007/s12035-018-1439-4, Published by Humana Press, Totowa, NJ
Published: 2019

45. Association Between Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism and Progressive Brain Volume Changes in Schizophrenia

Author: Ho, Beng-Choon, Andreasen, Nancy C., Dawson, Jeffrey D., and Wassink, Thomas H.
Published: 2007

46. Genetic architecture of subcortical brain structures in 38,851 individuals

Author: Satizabal, Claudia L, Adams, Hieab H H, Hibar, Derrek P, White, Charles C, Knol, Maria J, Stein, Jason L, Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V, Smith, Albert V, Bis, Joshua C, Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J, Yang, Jingyun, Yanek, Lisa R, Lee, Tom V, Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D, Desrivières, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentería, Miguel E, Kim, Sungeun, Hoehn, David, Armstrong, Nicola J, Chen, Qiang, Holmes, Avram J, den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santiañez, Roberto, Kraemer, Bernd, Håberg, Asta K, Jones, Hannah J, Pike, G Bruce, Stein, Dan J, Stevens, Allison, Bralten, Janita, Vernooij, Meike W, Harris, Tamara B, Filippi, Irina, Witte, A Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H, Becker, James T, Doan, Nhat Trung, Hagenaars, Saskia P, Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M, Ames, David, Goldman, Aaron L, Lee, Phil H, Boomsma, Dorret I, Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M, Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M, Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E, Shin, Jean, Ipser, Jonathan C, Vinke, Louis N, Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K, Aribisala, Benjamin S, Schmidt, Helena, Strike, Lachlan T, Cheng, Ching-Yu, Risacher, Shannon L, Pütz, Benno, Fleischman, Debra A, Assareh, Amelia A, Mattay, Venkata S, Buckner, Randy L, Mecocci, Patrizia, Dale, Anders M, Cichon, Sven, Boks, Marco P, Matarin, Mar, Penninx, Brenda W J H, Calhoun, Vince D, Chakravarty, M Mallar, Marquand, Andre F, Macare, Christine, Kharabian Masouleh, Shahrzad, Oosterlaan, Jaap, Amouyel, Philippe, Hegenscheid, Katrin, Rotter, Jerome I, Schork, Andrew J, Liewald, David C M, de Zubicaray, Greig I, Wong, Tien Yin, Shen, Li, Sämann, Philipp G, Brodaty, Henry, Roffman, Joshua L, de Geus, Eco J C, Tsolaki, Magda, Erk, Susanne, van Eijk, Kristel R, Cavalleri, Gianpiero L, van der Wee, Nic J A, McIntosh, Andrew M, Gollub, Randy L, Bulayeva, Kazima B, Bernard, Manon, Richards, Jennifer S, Himali, Jayandra J, Loeffler, Markus, Rommelse, Nanda, Hoffmann, Wolfgang, Westlye, Lars T, Valdés Hernández, Maria C, Hansell, Narelle K, van Erp, Theo G M, Wolf, Christiane, Kwok, John B J, Vellas, Bruno, Heinz, Andreas, Olde Loohuis, Loes M, Delanty, Norman, Ho, Beng-Choon, Ching, Christopher R K, Shumskaya, Elena, Singh, Baljeet, Hofman, Albert, van der Meer, Dennis, Homuth, Georg, Psaty, Bruce M, Bastin, Mark E, Montgomery, Grant W, Foroud, Tatiana M, Reppermund, Simone, Hottenga, Jouke-Jan, Simmons, Andrew, Meyer-Lindenberg, Andreas, Cahn, Wiepke, Whelan, Christopher D, van Donkelaar, Marjolein M J, Yang, Qiong, Hosten, Norbert, Green, Robert C, Thalamuthu, Anbupalam, Mohnke, Sebastian, Hulshoff Pol, Hilleke E, Lin, Honghuang, Jack, Clifford R, Schofield, Peter R, Mühleisen, Thomas W, Maillard, Pauline, Potkin, Steven G, Wen, Wei, Fletcher, Evan, Toga, Arthur W, Gruber, Oliver, Huentelman, Matthew, Davey Smith, George, Launer, Lenore J, Nyberg, Lars, Jönsson, Erik G, Crespo-Facorro, Benedicto, Koen, Nastassja, Greve, Douglas N, Uitterlinden, André G, Weinberger, Daniel R, Steen, Vidar M, Fedko, Iryna O, Groenewold, Nynke A, Niessen, Wiro J, Toro, Roberto, Tzourio, Christophe, Longstreth, William T, Ikram, M Kamran, Smoller, Jordan W, van Tol, Marie-Jose, Sussmann, Jessika E, Paus, Tomas, Lemaître, Hervé, Schroeter, Matthias L, Mazoyer, Bernard, Andreassen, Ole A, Holsboer, Florian, Depondt, Chantal, Veltman, Dick J, Turner, Jessica A, Pausova, Zdenka, Schumann, Gunter, van Rooij, Daan, Djurovic, Srdjan, Deary, Ian J, McMahon, Katie L, Müller-Myhsok, Bertram, Brouwer, Rachel M, Soininen, Hilkka, Pandolfo, Massimo, Wassink, Thomas H, Cheung, Joshua W, Wolfers, Thomas, Martinot, Jean-Luc, Zwiers, Marcel P, Nauck, Matthias, Melle, Ingrid, Martin, Nicholas G, Kanai, Ryota, Westman, Eric, Kahn, René S, Sisodiya, Sanjay M, White, Tonya, Saremi, Arvin, van Bokhoven, Hans, Brunner, Han G, Völzke, Henry, Wright, Margaret J, van 't Ent, Dennis, Nöthen, Markus M, Ophoff, Roel A, Buitelaar, Jan K, Fernández, Guillén, Sachdev, Perminder S, Rietschel, Marcella, van Haren, Neeltje E M, Fisher, Simon E, Beiser, Alexa S, Francks, Clyde, Saykin, Andrew J, Mather, Karen A, Romanczuk-Seiferth, Nina, Hartman, Catharina A, DeStefano, Anita L, Heslenfeld, Dirk J, Weiner, Michael W, Walter, Henrik, Hoekstra, Pieter J, Nyquist, Paul A, Franke, Barbara, Bennett, David A, Grabe, Hans J, Johnson, Andrew D, Chen, Christopher, van Duijn, Cornelia M, Lopez, Oscar L, Fornage, Myriam, Wardlaw, Joanna M, Schmidt, Reinhold, DeCarli, Charles, De Jager, Philip L, Villringer, Arno, Debette, Stéphanie, Gudnason, Vilmundur, Medland, Sarah E, Shulman, Joshua M, Thompson, Paul M, Seshadri, Sudha, Ikram, M Arfan, Satizabal, Claudia L, Adams, Hieab H H, Hibar, Derrek P, White, Charles C, Knol, Maria J, Stein, Jason L, Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V, Smith, Albert V, Bis, Joshua C, Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J, Yang, Jingyun, Yanek, Lisa R, Lee, Tom V, Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D, Desrivières, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentería, Miguel E, Kim, Sungeun, Hoehn, David, Armstrong, Nicola J, Chen, Qiang, Holmes, Avram J, den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santiañez, Roberto, Kraemer, Bernd, Håberg, Asta K, Jones, Hannah J, Pike, G Bruce, Stein, Dan J, Stevens, Allison, Bralten, Janita, Vernooij, Meike W, Harris, Tamara B, Filippi, Irina, Witte, A Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H, Becker, James T, Doan, Nhat Trung, Hagenaars, Saskia P, Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M, Ames, David, Goldman, Aaron L, Lee, Phil H, Boomsma, Dorret I, Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M, Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M, Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E, Shin, Jean, Ipser, Jonathan C, Vinke, Louis N, Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K, Aribisala, Benjamin S, Schmidt, Helena, Strike, Lachlan T, Cheng, Ching-Yu, Risacher, Shannon L, Pütz, Benno, Fleischman, Debra A, Assareh, Amelia A, Mattay, Venkata S, Buckner, Randy L, Mecocci, Patrizia, Dale, Anders M, Cichon, Sven, Boks, Marco P, Matarin, Mar, Penninx, Brenda W J H, Calhoun, Vince D, Chakravarty, M Mallar, Marquand, Andre F, Macare, Christine, Kharabian Masouleh, Shahrzad, Oosterlaan, Jaap, Amouyel, Philippe, Hegenscheid, Katrin, Rotter, Jerome I, Schork, Andrew J, Liewald, David C M, de Zubicaray, Greig I, Wong, Tien Yin, Shen, Li, Sämann, Philipp G, Brodaty, Henry, Roffman, Joshua L, de Geus, Eco J C, Tsolaki, Magda, Erk, Susanne, van Eijk, Kristel R, Cavalleri, Gianpiero L, van der Wee, Nic J A, McIntosh, Andrew M, Gollub, Randy L, Bulayeva, Kazima B, Bernard, Manon, Richards, Jennifer S, Himali, Jayandra J, Loeffler, Markus, Rommelse, Nanda, Hoffmann, Wolfgang, Westlye, Lars T, Valdés Hernández, Maria C, Hansell, Narelle K, van Erp, Theo G M, Wolf, Christiane, Kwok, John B J, Vellas, Bruno, Heinz, Andreas, Olde Loohuis, Loes M, Delanty, Norman, Ho, Beng-Choon, Ching, Christopher R K, Shumskaya, Elena, Singh, Baljeet, Hofman, Albert, van der Meer, Dennis, Homuth, Georg, Psaty, Bruce M, Bastin, Mark E, Montgomery, Grant W, Foroud, Tatiana M, Reppermund, Simone, Hottenga, Jouke-Jan, Simmons, Andrew, Meyer-Lindenberg, Andreas, Cahn, Wiepke, Whelan, Christopher D, van Donkelaar, Marjolein M J, Yang, Qiong, Hosten, Norbert, Green, Robert C, Thalamuthu, Anbupalam, Mohnke, Sebastian, Hulshoff Pol, Hilleke E, Lin, Honghuang, Jack, Clifford R, Schofield, Peter R, Mühleisen, Thomas W, Maillard, Pauline, Potkin, Steven G, Wen, Wei, Fletcher, Evan, Toga, Arthur W, Gruber, Oliver, Huentelman, Matthew, Davey Smith, George, Launer, Lenore J, Nyberg, Lars, Jönsson, Erik G, Crespo-Facorro, Benedicto, Koen, Nastassja, Greve, Douglas N, Uitterlinden, André G, Weinberger, Daniel R, Steen, Vidar M, Fedko, Iryna O, Groenewold, Nynke A, Niessen, Wiro J, Toro, Roberto, Tzourio, Christophe, Longstreth, William T, Ikram, M Kamran, Smoller, Jordan W, van Tol, Marie-Jose, Sussmann, Jessika E, Paus, Tomas, Lemaître, Hervé, Schroeter, Matthias L, Mazoyer, Bernard, Andreassen, Ole A, Holsboer, Florian, Depondt, Chantal, Veltman, Dick J, Turner, Jessica A, Pausova, Zdenka, Schumann, Gunter, van Rooij, Daan, Djurovic, Srdjan, Deary, Ian J, McMahon, Katie L, Müller-Myhsok, Bertram, Brouwer, Rachel M, Soininen, Hilkka, Pandolfo, Massimo, Wassink, Thomas H, Cheung, Joshua W, Wolfers, Thomas, Martinot, Jean-Luc, Zwiers, Marcel P, Nauck, Matthias, Melle, Ingrid, Martin, Nicholas G, Kanai, Ryota, Westman, Eric, Kahn, René S, Sisodiya, Sanjay M, White, Tonya, Saremi, Arvin, van Bokhoven, Hans, Brunner, Han G, Völzke, Henry, Wright, Margaret J, van 't Ent, Dennis, Nöthen, Markus M, Ophoff, Roel A, Buitelaar, Jan K, Fernández, Guillén, Sachdev, Perminder S, Rietschel, Marcella, van Haren, Neeltje E M, Fisher, Simon E, Beiser, Alexa S, Francks, Clyde, Saykin, Andrew J, Mather, Karen A, Romanczuk-Seiferth, Nina, Hartman, Catharina A, DeStefano, Anita L, Heslenfeld, Dirk J, Weiner, Michael W, Walter, Henrik, Hoekstra, Pieter J, Nyquist, Paul A, Franke, Barbara, Bennett, David A, Grabe, Hans J, Johnson, Andrew D, Chen, Christopher, van Duijn, Cornelia M, Lopez, Oscar L, Fornage, Myriam, Wardlaw, Joanna M, Schmidt, Reinhold, DeCarli, Charles, De Jager, Philip L, Villringer, Arno, Debette, Stéphanie, Gudnason, Vilmundur, Medland, Sarah E, Shulman, Joshua M, Thompson, Paul M, Seshadri, Sudha, and Ikram, M Arfan
Abstract: Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
Published: 2019
Full Text: View/download PDF

47. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Author: Franke, Barbara, Stein, Jason L, McIntosh, Andrew M, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H, Farrell, Martilias S, Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B, Lee, Phil, Friedman, Joseph I, Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Gershon, Elliot S, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I, Gopal, Srihari, McMahon, Francis J, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L, Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M, Henskens, Frans A, Herms, Stefan L, Meyer-Lindenberg, Andreas, Hirschhorn, Joel N, Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V, Hougaard, David M, Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kähler, Anna K, Kahn, René S, Mattheisen, Manuel, Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C, Kelly, Brian J, Kennedy, James L, Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Andreassen, Ole A, Knowles, James A, Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Laurent, Claudine, Lee, S Hong, Keong, Jimmy Lee Chee, Legge, Sophie E, Lerer, Bernard, Gruber, Oliver, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Lönnqvist, Jouko, Loughland, Carmel M, Lubinski, Jan, Macek, Milan, Magnusson, Patrik K E, Sachdev, Perminder S, Maher, Brion S, Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattingsdal, Morten, McCarley, Robert W, McDonald, Colm, Meier, Sandra, Roiz-Santiañez, Roberto, Meijer, Carin J, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I, Metspalu, Andres, Michie, Patricia T, Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W, Saykin, Andrew J, Mors, Ole, Müller-Myhsok, Bertram, Murphy, Kieran C, Murray, Robin M, Myin-Germeys, Inez, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A, Nestadt, Gerald, Nicodemus, Kristin K, Ripke, Stephan, Ehrlich, Stefan, Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, O'Neill, F Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Mather, Karen A, Pantelis, Christos, Papadimitriou, George N, Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T, Paunio, Tiina, Perkins, Diana O, Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J, Turner, Jessica A, Powell, John, Price, Alkes, Pulver, Ann E, Purcell, Shaun M, Quested, Digby, Rasmussen, Henrik B, Reichenberg, Abraham, Reimers, Mark A, Richards, Alexander L, Roffman, Joshua L, Schwarz, Emanuel, Roussos, Panos, Ruderfer, Douglas M, Salomaa, Veikko, Sanders, Alan R, Schall, Ulrich, Schubert, Christian R, Schulze, Thomas G, Schwab, Sibylle G, Scolnick, Edward M, Scott, Rodney J, Thalamuthu, Anbupalam, Seidman, Larry J, Shi, Jianxin, Silverman, Jeremy M, Sim, Kang, Slominsky, Petr, Smoller, Jordan W, So, Hon-Cheong, Söderman, Erik, Spencer, Chris C A, Stahl, Eli A, Shugart, Yin Yao, Stogmann, Elisabeth, Straub, Richard E, Strengman, Eric, Strohmaier, Jana, Stroup, T Scott, Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M, Szatkiewicz, Jin P, Thirumalai, Srinivas, Ho, Yvonne Yw, Toncheva, Draga, Tooney, Paul A, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T, Weiser, Mark, Wildenauer, Dieter B, Martin, Nicholas G, Williams, Nigel M, Williams, Stephanie, Witt, Stephanie H, Wolen, Aaron R, Wong, Emily H M, Wormley, Brandon K, Wu, Jing Qin, Xi, Hualin Simon, Zai, Clement C, Zheng, Xuebin, Wright, Margaret J, Zimprich, Fritz, Wray, Naomi R, Visscher, Peter M, Adolfsson, Rolf, Blackwood, Douglas H R, Børglum, Anders D, Bramon, Elvira, Buxbaum, Joseph D, Cichon, Sven, Consortium, Schizophrenia Working Group of the Psychiatric Genomics, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V, Gill, Michael, Gurling, Hugh, Hultman, Christina M, Iwata, Nakao, Jablensky, Assen V, Anttila, Verneri, Consortium, ENIGMA, Jönsson, Erik G, Kendler, Kenneth S, Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F, Li, Qingqin S, Liu, Jianjun, Malhotra, Anil K, McCarroll, Steven A, O'Donovan, Michael C, McQuillin, Andrew, Moran, Jennifer L, Mortensen, Preben B, Mowry, Bryan J, Nöthen, Markus M, Ophoff, Roel A, Owen, Michael J, Palotie, Aarno, Pato, Carlos N, Petryshen, Tracey L, Thompson, Paul M, Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P, Rujescu, Dan, Sham, Pak C, Sklar, Pamela, Clair, David St, Weinberger, Daniel R, Wendland, Jens R, Werge, Thomas, Neale, Benjamin M, Daly, Mark J, Sullivan, Patrick F, Hibar, Derrek P, Renteria, Miguel E, Arias-Vasquez, Alejandro, Desrivières, Sylvane, Jahanshad, Neda, Toro, Roberto, Medland, Sarah E, Wittfeld, Katharina, Abramovic, Lucija, Andersson, Micael, Aribisala, Benjamin S, Armstrong, Nicola J, Bernard, Manon, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brown, Andrew A, Chakravarty, M Mallar, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, den Braber, Anouk, Giddaluru, Sudheer, Goldman, Aaron L, Grimm, Oliver, Guadalupe, Tulio, Hass, Johanna, Woldehawariat, Girma, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Loohuis, Loes M Olde, Luciano, Michelle, Macare, Christine, Milaneschi, Yuri, Nho, Kwangsik, Papmeyer, Martina, Ramasamy, Adaikalavan, Risacher, Shannon L, Corvin, Aiden, Rose, Emma J, Salami, Alireza, Sämann, Philipp G, Schmaal, Lianne, Schork, Andrew J, Shin, Jean, Strike, Lachlan T, Teumer, Alexander, van Donkelaar, Marjolein M J, van Eijk, Kristel R, Walters, James T R, Walters, Raymond K, Westlye, Lars T, Whelan, Christopher D, Winkler, Anderson M, Zwiers, Marcel P, Alhusaini, Saud, Athanasiu, Lavinia, Hakobjan, Marina M H, Hartberg, Cecilie B, Farh, Kai-How, Haukvik, Unn, Heister, Angelien J G A M, Höhn, David, Kasperaviciute, Dalia, Liewald, David C M, Lopez, Lorna M, Makkinje, Remco R R, Matarin, Mar, Naber, Marlies A M, McKay, David R, Holmans, Peter A, Needham, Margaret, Nugent, Allison C, Pütz, Benno, Royle, Natalie A, Shen, Li, Sprooten, Emma, Trabzuni, Daniah, van der Marel, Saskia S L, van Hulzen, Kimm J E, Walton, Esther, Wolf, Christiane, Almasy, Laura, Ames, David, Arepalli, Sampath, Assareh, Amelia A, Bastin, Mark E, Brodaty, Henry, Bulayeva, Kazima B, Carless, Melanie A, Bulik-Sullivan, Brendan, Curran, Joanne E, Czisch, Michael, de Zubicaray, Greig I, Dillman, Allissa, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Fedko, Iryna O, Ferrucci, Luigi, Collier, David A, Foroud, Tatiana M, Fox, Peter T, Fukunaga, Masaki, Gibbs, Raphael, Göring, Harald H H, Green, Robert C, Guelfi, Sebastian, Hansell, Narelle K, Hartman, Catharina A, Hegenscheid, Katrin, Huang, Hailiang, Heinz, Andreas, Hernandez, Dena G, Heslenfeld, Dirk J, Hoekstra, Pieter J, Holsboer, Florian, Homuth, Georg, Hottenga, Jouke-Jan, Jack, Clifford R, Jenkinson, Mark, Pers, Tune H, Johnson, Robert, Kanai, Ryota, Keil, Maria, Kent, Jack W, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Liu, Xinmin, Longo, Dan L, McMahon, Katie L, Agartz, Ingrid, Meisenzahl, Eva, Mohnke, Sebastian, Montgomery, Grant W, Mostert, Jeanette C, Mühleisen, Thomas W, Nalls, Michael A, Nichols, Thomas E, Nilsson, Lars G, Agerbo, Esben, Ohi, Kazutaka, Olvera, Rene L, Perez-Iglesias, Rocio, Pike, G Bruce, Potkin, Steven G, Reinvang, Ivar, Reppermund, Simone, Romanczuk-Seiferth, Nina, Rosen, Glenn D, Albus, Margot, Schnell, Knut, Schofield, Peter R, Smith, Colin, Steen, Vidar M, Sussmann, Jessika E, Toga, Arthur W, Traynor, Bryan, Troncoso, Juan, Alexander, Madeline, Hernández, Maria C Valdés, van 't Ent, Dennis, van der Brug, Marcel, van der Wee, Nic J A, van Tol, Marie-Jose, Veltman, Dick J, Wassink, Thomas H, Westman, Eric, Zielke, Ronald H, Amin, Farooq, Zonderman, Alan, Ashbrook, David G, Hager, Reinmar, Lu, Lu, Williams, Robert W, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bacanu, Silviu A, Cahn, Wiepke, Calhoun, Vince D, Cavalleri, Gianpiero L, Crespo-Facorro, Benedicto, Dale, Anders M, Davies, Gareth E, Delanty, Norman, Depondt, Chantal, Djurovic, Srdjan, Drevets, Wayne C, Begemann, Martin, Espeseth, Thomas, Gollub, Randy L, Ho, Beng-Choon, Hoffmann, Wolfgang, Hosten, Norbert, LeHellard, Stephanie, Nauck, Matthias, Belliveau, Richard A, Nyberg, Lars, Pandolfo, Massimo, Penninx, Brenda W J H, Sisodiya, Sanjay M, van Bokhoven, Hans, van Haren, Neeltje E M, Völzke, Henry, Walter, Henrik, Bene, Judit, Weiner, Michael W, Wen, Wei, White, Tonya, Blangero, John, Boomsma, Dorret I, Brouwer, Rachel M, Cannon, Dara M, Cookson, Mark R, Bergen, Sarah E, de Geus, Eco J C, Deary, Ian J, Donohoe, Gary, Fernández, Guillén, Fisher, Simon E, Francks, Clyde, Glahn, David C, Grabe, Hans J, Hardy, John, Bevilacqua, Elizabeth, Hashimoto, Ryota, Hulshoff Pol, Hilleke E, Kloszewska, Iwona, Lovestone, Simon, Mattay, Venkata S, Mecocci, Patrizia, Bigdeli, Tim B, Paus, Tomas, Pausova, Zdenka, Ryten, Mina, Simmons, Andy, Singleton, Andrew, Soininen, Hilkka, Wardlaw, Joanna M, Weale, Michael E, Black, Donald W, Adams, Hieab H H, Launer, Lenore J, Seiler, Stephan, Schmidt, Reinhold, Chauhan, Ganesh, Satizabal, Claudia L, Becker, James T, Yanek, Lisa, van der Lee, Sven J, Bruggeman, Richard, Ebling, Maritza, Fischl, Bruce, Longstreth, W. T., Greve, Douglas, Schmidt, Helena, Nyquist, Paul, Vinke, Louis N, van Duijn, Cornelia M, Luting, Xue, Mazoyer, Bernard, Buccola, Nancy G, Bis, Joshua C, Gudnason, Vilmundur, Seshadri, Sudha, Ikram, M Arfan, Schumann, Gunter, Byerley, William F, Cai, Guiqing, Cairns, Murray J, Campion, Dominique, Cantor, Rita M, Carr, Vaughan J, Carrera, Noa, Catts, Stanley V, Chambert, Kimberley D, Chan, Raymond C K, Chen, Eric Y H, Chen, Ronald Y L, Cheng, Wei, Cheung, Eric F C, Chong, Siow Ann, Cloninger, C Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J, Curtis, David, Davidson, Michael, Davis, Kenneth L, Degenhardt, Franziska, Neale, Michael C, Del Favero, Jurgen, DeLisi, Lynn E, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Franke, Barbara, Stein, Jason L, Ripke, Stephan, Anttila, Verneri, Hong Lee, S, Ikram, M Arfan, Schizophrenia Working Group of the Psychiatric Genomics Consortium, ENIGMA Consortium, Radboud University Medical Center [Nijmegen], University of Southern California (USC), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Massachusetts General Hospital [Boston], University of Warwick [Coventry], University of Oxford [Oxford], Virginia Commonwealth University (VCU), University of Edinburgh, National Institutes of Health [Bethesda] (NIH), Chinese PLA General Hospital, University of Missouri [Columbia], University of Missouri System, Cardiff University, Aarhus University [Aarhus], Stanford University [Stanford], Max-Planck-Institut, University of Iowa [Iowa City], Icahn School of Medicine at Mount Sinai [New York] (MSSM), Schizophrenia Research Institute [Sydney], Génétique du cancer et des maladies neuropsychiatriques (GMFC), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Mathematics [CUHK], The Chinese University of Hong Kong [Hong Kong], The University of Hong Kong (HKU), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Castle Peak Hospital [Hong Kong], Institute of Mental Health [Singapore], Service de psychiatrie des enfants et adultes [CHU Pitié-Salpêtrière ], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Queen Mary University of London (QMUL), Open University of Israël, University of Antwerp (UA), Harvard Medical School [Boston] (HMS), University of Athens Medical School [Athens], University College Cork (UCC), University of Oslo (UiO), London School of Hygiene and Tropical Medicine (LSHTM), Universität Regensburg (UR), Biomedicum Helsinki, Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], Universität Heidelberg [Heidelberg], University Medical Center Groningen [Groningen] (UMCG), Haverford College, Service de Pharmacologie, toxicologie et pharmacovigilance [CHU Limoges], CHU Limoges, University of Queensland [Brisbane], James J. Peters VA Medical Center [New York], Martin-Luther-University Halle-Wittenberg, University of Newcastle [Australia] (UoN), University of Basel (Unibas), Division of Medical Genetics [Seattle], University of Washington [Seattle], Statens Serum Institut [Copenhagen], Tohoku University [Sendai], University of Stavanger, Institut de biologie structurale (IBS - UMR 5075), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), University of Sofia, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Universität Stuttgart [Stuttgart], Russian Academy of Sciences [Moscow] (RAS), Latvian Biomedical Research and Study Centre [Rīga], Vilnius University [Vilnius], University Hospital Motol [Prague], Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hadassah Hebrew University Medical Center [Jerusalem], Karolinska Institutet [Stockholm], University of Bonn, Génétique moléculaire de la neurotransmission et des processus neurodégénératifs (LGMNPN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Vall d'Hebron University Hospital [Barcelona], Department of Life Sciences, Imperial College London, Deutscher Wetterdienst [Offenbach] (DWD), Eli Lilly and Company Limited [Windlesham], Trinity College Dublin, Royal College of Surgeons in Ireland (RCSI), Université de Lausanne (UNIL), University of Tartu, Johns Hopkins University School of Medicine [Baltimore], Stockholm University, Queen's University [Belfast] (QUB), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Universidade de São Paulo (USP), Department of Mathematics [Nanticoke], Luzerne County Community College, National Institute for Health and Welfare [Helsinki], King‘s College London, University of Chicago, Fraunhofer Heinrich Hertz Institute [Berlin] (HHI), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), National Cancer Institute [Bethesda] (NCI-NIH), The Wellcome Trust Centre for Human Genetics [Oxford], Department of Genetic Epidemiology in Psychiatry [Mannhein], Universität Heidelberg [Heidelberg]-Central Institute of Mental Health Mannheim, The Natural History Museum [London] (NHM), University of Calgary, Department of Medical Epidemiology and Biostatistics (MEB), The University of Western Australia (UWA), Rheinische Friedrich-Wilhelms-Universität Bonn, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Montreal Neurological Institute and Hospital, McGill University, Universidade do Algarve (UAlg), Beijing Normal University, Structure et Réactivité des Systèmes Moléculaires Complexes (SRSMC), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Dpt of Psychiatry [New Haven], Yale University School of Medicine, Centre épigénétique et destin cellulaire (EDC (UMR_7216)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Bijvoet Center of Biomolecular Research, Utrecht University [Utrecht], School of Psychology, University of Queensland, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Department of Mathematics, University of Colorado, University of Colorado [Boulder], VU University Amsterdam, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Department of Health and Human Services, McConnell Brain Imaging Centre (MNI), McGill University-McGill University, Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Computer Science and Artificial Intelligence Laboratory [Cambridge] (CSAIL), Massachusetts Institute of Technology (MIT), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Del-Favero, Jurgen, Enigma Consortium, School of Medicine / Clinical Medicine, University of Oxford, University of Missouri [Columbia] (Mizzou), Stanford University, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universität Heidelberg [Heidelberg] = Heidelberg University, University of Newcastle [Callaghan, Australia] (UoN), Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Софийски университет = Sofia University, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universität Bonn = University of Bonn, Université de Lausanne = University of Lausanne (UNIL), Universidade de São Paulo = University of São Paulo (USP), Fraunhofer Institute for Telecommunications - Heinrich Hertz Institute (Fraunhofer HHI), Fraunhofer (Fraunhofer-Gesellschaft), Universität Heidelberg [Heidelberg] = Heidelberg University-Central Institute of Mental Health Mannheim, Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), McGill University = Université McGill [Montréal, Canada], Beijing Normal University (BNU), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Yale School of Medicine [New Haven, Connecticut] (YSM), Centre épigénétique et destin cellulaire (EDC), Bijvoet Center of Biomolecular Research [Utrecht], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Vrije Universiteit Amsterdam [Amsterdam] (VU), McGill University = Université McGill [Montréal, Canada]-McGill University = Université McGill [Montréal, Canada], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Biological Psychology, EMGO+ - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Other departments, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), and MUMC+: Hersen en Zenuw Centrum (3)
Subjects: 0301 basic medicine, Netherlands Twin Register (NTR), genetic association, Genome-wide association study, brain imaging, VARIANTS, Genome-wide association studies, Linkage Disequilibrium, 0302 clinical medicine, pathology [Brain], 2.1 Biological and endogenous factors, Psychology, GWAS, genetics [Schizophrenia], genetics, genetics [Genetic Predisposition to Disease], Aetiology, Non-U.S. Gov't, PERSPECTIVE, humans, Schizophrenia Working Group of the Psychiatric Genomics Consortium, neuroimaging, General Neuroscience, Research Support, Non-U.S. Gov't, Brain, Single Nucleotide, Organ Size, Endophenotypes, Genetic Predisposition to Disease, Humans, Magnetic Resonance Imaging, Neuroimaging, Polymorphism, Single Nucleotide, Schizophrenia, Genome-Wide Association Study, Neuroscience (all), Serious Mental Illness, ENIGMA Consortium, 3. Good health, endophenotype, Mental Health, Meta-analysis, Neurological, genetics [Polymorphism, Single Nucleotide], Cognitive Sciences, MRI, Neuroinformatics, DISORDERS, heredity, Schizophrenia (object-oriented programming), brain, Non-P.H.S, Brain Structure and Function, RELATIVES, PHENOTYPES, Research Support, N.I.H, 03 medical and health sciences, Magnetic resonance imaging, ENDOPHENOTYPE, Research Support, N.I.H., Extramural, ddc:570, Journal Article, Polymorphism, GENOME-WIDE ASSOCIATION, pathology [Schizophrenia], METAANALYSIS, genetic predisposition to disease, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Neurology & Neurosurgery, genome-wide association study, [SCCO.NEUR]Cognitive science/Neuroscience, Human Genome, Neurosciences, Extramural, Genetic architecture, Brain Disorders, meta-analysis, schizophrenia, INDIVIDUALS, 030104 developmental biology, Genetic marker, Endophenotype, DISCOVERY, Genetic markers, U.S. Gov't, Human medicine, Neuroscience, genetic predisposition, 030217 neurology & neurosurgery, Research Support, U.S. Gov't, Non-P.H.S, Meta-Analysis
Abstract: Article, Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders., final draft, peerReviewed
Published: 2016

48. Prevalence of Depressive Symptoms Early in the Course of Schizophrenia

Author: Wassink, Thomas H., Flaum, Michael, Nopoulos, Peg, and Andreasen, Nancy C.
Published: 1999

49. Cerebellar morphology as a predictor of symptom and psychosocial outcome in schizophrenia

Author: Wassink, Thomas H, Andreasen, Nancy C, Nopoulos, Peg, and Flaum, Michael
Published: 1999
Full Text: View/download PDF

50. Novel genetic loci associated with hippocampal volume

Author: Hibar, Derrek P., Adams, Hieab H. H., Jahanshad, Neda, Chauhan, Ganesh, Stein, Jason L., Hofer, Edith, Renteria, Miguel E., Bis, Joshua C., Arias-Vasquez, Alejandro, Ikram, M. Kamran, Desrivieres, Sylvane, Vernooij, Meike W., Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S., Armstrong, Nicola J., Athanasiu, Lavinia, Axelsson, Tomas, Beecham, Ashley H., Beiser, Alexa, Bernard, Manon, Blanton, Susan H., Bohlken, Marc M., Boks, Marco P., Bralten, Janita, Brickman, Adam M., Carmichael, Owen, Chakravarty, M. Mallar, Chen, Qiang, Ching, Christopher R. K., Chouraki, Vincent, Cuellar-Partida, Gabriel, Crivello, Fabrice, Den Braber, Anouk, Doan, Nhat Trung, Ehrlich, Stefan, Giddaluru, Sudheer, Goldman, Aaron L., Gottesman, Rebecca F., Grimm, Oliver, Griswold, Michael E., Guadalupe, Tulio, Gutman, Boris A., Hass, Johanna, Haukvik, Unn K., Hoehn, David, Holmes, Avram J., Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Jorgensen, Kjetil N., Karbalai, Nazanin, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H., Liewald, David C. M., Lopez, Lorna M., Luciano, Michelle, Macare, Christine, Marquand, Andre F., Matarin, Mar, Mather, Karen A., Mattheisen, Manuel, McKay, David R., Milaneschi, Yuri, Maniega, Susana Munoz, Nho, Kwangsik, Nugent, Allison C., Nyquist, Paul, Loohuis, Loes M. Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pirpamer, Lukas, Puetz, Benno, Ramasamy, Adaikalavan, Richards, Jennifer S., Risacher, Shannon L., Roiz-Santianez, Roberto, Rommelse, Nanda, Ropele, Stefan, Rose, Emma J., Royle, Natalie A., Rundek, Tatjana, Saemann, Philipp G., Saremi, Arvin, Satizabal, Claudia L., Schmaal, Lianne, Schork, Andrew J., Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V., Sprooten, Emma, Strike, Lachlan T., Teumer, Alexander, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Trompet, Stella, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Lee, Sven J., van der Meer, Dennis, Van Donkelaar, Marjolein M. J., Van Eijk, Kristel R., Van Erp, Theo G. M., Van Rooij, Daan, Walton, Esther, Westlye, Lars T., Whelan, Christopher D., Windham, Beverly G., Winkler, Anderson M., Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Yanek, Lisa R., Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P., Agartz, Ingrid, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A., Arepalli, Sampath, Assareh, Amelia A., Barral, Sandra, Bastin, Mark E., Becker, Diane M., Becker, James T., Bennett, David A., Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I., Brodaty, Henry, Brouwer, Rachel M., Brunner, Han G., Buckner, Randy L., Buitelaar, Jan K., Bulayeva, Kazima B., Cahn, Wiepke, Calhoun, Vince D., Cannon, Dara M., Cavalleri, Gianpiero L., Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R., Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E., Czisch, Michael, Dale, Anders M., Davies, Gareth E., De Craen, Anton J. M., De Geus, Eco J. C., De Jager, Philip L., De Zubicaray, Greig I., Deary, Ian J., Debette, Stephanie, DeCarli, Charles, Delanty, Norman, Depondt, Chantal, DeStefano, Anita, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C., Duggirala, Ravi, Dyer, Thomas D., Enzinger, Christian, Erk, Susanne, Espeseth, Thomas, Fedko, Iryna O., Fernandez, Guillen, Ferrucci, Luigi, Fisher, Simon E., Fleischman, Debra A., Ford, Ian, Fornage, Myriam, Foroud, Tatiana M., Fox, Peter T., Francks, Clyde, Fukunaga, Masaki, Gibbs, J. Raphael, Glahn, David C., Gollub, Randy L., Goring, Harald H. H., Green, Robert C., Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Haberg, Asta K., Hansell, Narelle K., Hardy, John, Hartman, Catharina A., Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G., Heslenfeld, Dirk J., Ho, Beng-Choon, Hoekstra, Pieter J., Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Huentelman, Matthew, Pol, Hilleke E. Hulshoff, Ikeda, Masashi, Jack, Clifford R., Jr., Jenkinson, Mark, Johnson, Robert, Joensson, Erik G., Jukema, J. Wouter, Kahn, Rene S., Kanai, Ryota, Kloszewska, Iwona, Knopman, David S., Kochunov, Peter, Kwok, John B., Lawrie, Stephen M., Lemaitre, Herve, Liu, Xinmin, Longo, Dan L., Lopez, Oscar L., Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S., McDonald, Colm, McIntosh, Andrew M., McMahon, Francis J., McMahon, Katie L., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W., Morris, Derek W., Mosley, Thomas H., Muhleisen, Thomas W., Mueller-Myhsok, Bertram, Nalls, Michael A., Nauck, Matthias, Nichols, Thomas E., Niessen, Wiro J., Nothen, Markus M., Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L., Ophoff, Roel A., Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W. J. H., Pike, G. Bruce, Potkin, Steven G., Psaty, Bruce M., Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L., Romanczuk-Seiferth, Nina, Rotter, Jerome I., Ryten, Mina, Sacco, Ralph L., Sachdev, Perminder S., Saykin, Andrew J., Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter R., Sigursson, Sigurdur, Simmons, Andrew, Singleton, Andrew, Sisodiya, Sanjay M., Smith, Colin, Smoller, Jordan W., Soininen, Hilkka, Steen, Vidar M., Stott, David J., Sussmann, Jessika E., Thalamuthu, Anbupalam, Toga, Arthur W., Traynor, Bryan J., Troncoso, Juan, Tsolaki, Magda, Tzourio, Christophe, Uitterlinden, Andre G., Hernandez, Maria C. Valdes, Van der Brug, Marcel, van der Lugt, Aad, van der Wee, Nic J. A., Van Haren, Neeltje E. M., van't Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N., Vellas, Bruno, Veltman, Dick J., Voelzke, Henry, Walter, Henrik, Wardlaw, Joanna M., Wassink, Thomas H., Weale, Michael E., Weinberger, Daniel R., Weiner, Michael W., Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y., Wright, Clinton B., Zielke, Ronald H., Zonderman, Alan B., Martin, Nicholas G., Van Duijn, Cornelia M., Wright, Margaret J., Longstreth, W. T., Schumann, Gunter, Grabe, Hans J., Franke, Barbara, Launer, Lenore J., Medland, Sarah E., Seshadri, Sudha, Thompson, Paul M., Ikram, M. Arfan, Hibar, Derrek P., Adams, Hieab H. H., Jahanshad, Neda, Chauhan, Ganesh, Stein, Jason L., Hofer, Edith, Renteria, Miguel E., Bis, Joshua C., Arias-Vasquez, Alejandro, Ikram, M. Kamran, Desrivieres, Sylvane, Vernooij, Meike W., Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S., Armstrong, Nicola J., Athanasiu, Lavinia, Axelsson, Tomas, Beecham, Ashley H., Beiser, Alexa, Bernard, Manon, Blanton, Susan H., Bohlken, Marc M., Boks, Marco P., Bralten, Janita, Brickman, Adam M., Carmichael, Owen, Chakravarty, M. Mallar, Chen, Qiang, Ching, Christopher R. K., Chouraki, Vincent, Cuellar-Partida, Gabriel, Crivello, Fabrice, Den Braber, Anouk, Doan, Nhat Trung, Ehrlich, Stefan, Giddaluru, Sudheer, Goldman, Aaron L., Gottesman, Rebecca F., Grimm, Oliver, Griswold, Michael E., Guadalupe, Tulio, Gutman, Boris A., Hass, Johanna, Haukvik, Unn K., Hoehn, David, Holmes, Avram J., Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Jorgensen, Kjetil N., Karbalai, Nazanin, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H., Liewald, David C. M., Lopez, Lorna M., Luciano, Michelle, Macare, Christine, Marquand, Andre F., Matarin, Mar, Mather, Karen A., Mattheisen, Manuel, McKay, David R., Milaneschi, Yuri, Maniega, Susana Munoz, Nho, Kwangsik, Nugent, Allison C., Nyquist, Paul, Loohuis, Loes M. Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pirpamer, Lukas, Puetz, Benno, Ramasamy, Adaikalavan, Richards, Jennifer S., Risacher, Shannon L., Roiz-Santianez, Roberto, Rommelse, Nanda, Ropele, Stefan, Rose, Emma J., Royle, Natalie A., Rundek, Tatjana, Saemann, Philipp G., Saremi, Arvin, Satizabal, Claudia L., Schmaal, Lianne, Schork, Andrew J., Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V., Sprooten, Emma, Strike, Lachlan T., Teumer, Alexander, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Trompet, Stella, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Lee, Sven J., van der Meer, Dennis, Van Donkelaar, Marjolein M. J., Van Eijk, Kristel R., Van Erp, Theo G. M., Van Rooij, Daan, Walton, Esther, Westlye, Lars T., Whelan, Christopher D., Windham, Beverly G., Winkler, Anderson M., Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Yanek, Lisa R., Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P., Agartz, Ingrid, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A., Arepalli, Sampath, Assareh, Amelia A., Barral, Sandra, Bastin, Mark E., Becker, Diane M., Becker, James T., Bennett, David A., Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I., Brodaty, Henry, Brouwer, Rachel M., Brunner, Han G., Buckner, Randy L., Buitelaar, Jan K., Bulayeva, Kazima B., Cahn, Wiepke, Calhoun, Vince D., Cannon, Dara M., Cavalleri, Gianpiero L., Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R., Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E., Czisch, Michael, Dale, Anders M., Davies, Gareth E., De Craen, Anton J. M., De Geus, Eco J. C., De Jager, Philip L., De Zubicaray, Greig I., Deary, Ian J., Debette, Stephanie, DeCarli, Charles, Delanty, Norman, Depondt, Chantal, DeStefano, Anita, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C., Duggirala, Ravi, Dyer, Thomas D., Enzinger, Christian, Erk, Susanne, Espeseth, Thomas, Fedko, Iryna O., Fernandez, Guillen, Ferrucci, Luigi, Fisher, Simon E., Fleischman, Debra A., Ford, Ian, Fornage, Myriam, Foroud, Tatiana M., Fox, Peter T., Francks, Clyde, Fukunaga, Masaki, Gibbs, J. Raphael, Glahn, David C., Gollub, Randy L., Goring, Harald H. H., Green, Robert C., Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Haberg, Asta K., Hansell, Narelle K., Hardy, John, Hartman, Catharina A., Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G., Heslenfeld, Dirk J., Ho, Beng-Choon, Hoekstra, Pieter J., Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Huentelman, Matthew, Pol, Hilleke E. Hulshoff, Ikeda, Masashi, Jack, Clifford R., Jr., Jenkinson, Mark, Johnson, Robert, Joensson, Erik G., Jukema, J. Wouter, Kahn, Rene S., Kanai, Ryota, Kloszewska, Iwona, Knopman, David S., Kochunov, Peter, Kwok, John B., Lawrie, Stephen M., Lemaitre, Herve, Liu, Xinmin, Longo, Dan L., Lopez, Oscar L., Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S., McDonald, Colm, McIntosh, Andrew M., McMahon, Francis J., McMahon, Katie L., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W., Morris, Derek W., Mosley, Thomas H., Muhleisen, Thomas W., Mueller-Myhsok, Bertram, Nalls, Michael A., Nauck, Matthias, Nichols, Thomas E., Niessen, Wiro J., Nothen, Markus M., Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L., Ophoff, Roel A., Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W. J. H., Pike, G. Bruce, Potkin, Steven G., Psaty, Bruce M., Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L., Romanczuk-Seiferth, Nina, Rotter, Jerome I., Ryten, Mina, Sacco, Ralph L., Sachdev, Perminder S., Saykin, Andrew J., Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter R., Sigursson, Sigurdur, Simmons, Andrew, Singleton, Andrew, Sisodiya, Sanjay M., Smith, Colin, Smoller, Jordan W., Soininen, Hilkka, Steen, Vidar M., Stott, David J., Sussmann, Jessika E., Thalamuthu, Anbupalam, Toga, Arthur W., Traynor, Bryan J., Troncoso, Juan, Tsolaki, Magda, Tzourio, Christophe, Uitterlinden, Andre G., Hernandez, Maria C. Valdes, Van der Brug, Marcel, van der Lugt, Aad, van der Wee, Nic J. A., Van Haren, Neeltje E. M., van't Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N., Vellas, Bruno, Veltman, Dick J., Voelzke, Henry, Walter, Henrik, Wardlaw, Joanna M., Wassink, Thomas H., Weale, Michael E., Weinberger, Daniel R., Weiner, Michael W., Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y., Wright, Clinton B., Zielke, Ronald H., Zonderman, Alan B., Martin, Nicholas G., Van Duijn, Cornelia M., Wright, Margaret J., Longstreth, W. T., Schumann, Gunter, Grabe, Hans J., Franke, Barbara, Launer, Lenore J., Medland, Sarah E., Seshadri, Sudha, Thompson, Paul M., and Ikram, M. Arfan
Abstract: The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
Published: 2017
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

281 results on '"Wassink, Thomas H"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources