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440 results on '"Wassilew, Georgi"'

3. Risk assessment of mixed and displacement ventilation (LAF) during orthopedic and trauma surgery on COVID-19 patients with increased release of infectious aerosols

Author

Kramer, Axel, Külpmann, Rüdiger, Brunner, Arnold, Müller, Michael, and Wassilew, Georgi

Subjects
displacement ventilation, laminar air flow, mixed ventilation, no ventilation, negative pressure, sars-cov-2 spread, Medicine, Public aspects of medicine, RA1-1270, Microbiology, QR1-502
Published
2020
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27. Implications for Femoral Tunnel Placement in Medial Patellofemoral Ligament Reconstruction Considering the Sagittal Trochlear Groove Curvature in Severe Trochlear Dysplasia Before and After Deepening Trochleoplasty.

Author

Balcarek, Peter, Zimmerer, Alexander, Wassilew, Georgi I., and Gebhardt, Sebastian

Subjects
KNEE joint, PLASTIC surgery, CRANIAL nerve diseases, PATELLAR tendon
Abstract

Background: Medial patellofemoral ligament reconstruction (MPFL-R) aims to restore proper ligament function with minimal changes in length during range of motion, yet the ideal area for femoral fixation of the graft remains controversial. Purpose: To determine the region where the isometric circular path of a simulated MPFL graft (best-fit circle) follows the sagittal radius curvature of the trochlea in normal (nontrochlear dysplastic) knees and to evaluate the best-fit circle coverage of different femoral fixation points in knees with severe trochlear dysplasia (TD) and after deepening trochleoplasty. Study Design: Controlled laboratory study. Methods: Twelve patients (4 male, 8 female; mean age, 24 ± 8 years) who underwent surgical treatment for recurrent lateral patellar instability due to severe TD were prospectively enrolled in this study. Four previously defined reference points for the femoral MPFL-R (Schöttle, Fujino, Stephen, and Oka) were identified, and the best-fit circle was drawn along the sagittal trochlear groove curvature. The divergence between each best-fit circle and the trochlear groove was calculated, with negative values indicating relative slackening and positive values indicating relative tightening of the simulated MPFL graft. Measurements were made on true-lateral fluoroscopic images before and after deepening trochleoplasty and compared with those of a sex-matched control group. Results: The best-fit circle of the Schöttle point followed the sagittal curvature of the trochlea most closely in both the control and trochlear dysplastic knees, followed by the Fujino, Stephen, and Oka points. As the radius of the trochlear groove curvature increased, the divergence of all best-fit circles to the trochlear groove became negative (all P <.05). This effect was most pronounced at the Stephen and Oka points, followed by the Fujino and Schöttle points (all P <.05). After deepening trochleoplasty, the divergence of the Schöttle point changed toward positive values (11.6% at 40°; P <.001). Concurrently, the best-fit circle divergence of all other reference points improved toward baseline (all P <.05). Conclusion: The isometric circle of the Schöttle point provides the best congruence with the sagittal trochlear groove curvature in both the normal trochlea and the dysplastic trochlea. After trochleoplasty, the best-fit circles of more distal femoral fixation points resulted in better congruence with the deepened trochlear groove, whereas the best-fit circle of Schöttle indicated graft tension during flexion. Clinical Relevance: According to the present study, different femoral fixation points should be considered depending on whether the TD is corrected. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Cold Physical Plasma Reduces Motility of Various Bone Sarcoma Cells While Remodeling the Cytoskeleton.

Author

NITSCH, ANDREAS, MARTHALER, PAULINE, QARQASH, SARA, BEMMANN, MAXIMILIAN, BEKESCHUS, SANDER, WASSILEW, GEORGI I., and HARALAMBIEV, LYUBOMIR

Subjects
OSTEOSARCOMA, CYTOSKELETON, CELL migration, CELL survival, ATMOSPHERIC pressure
Abstract

Background/Aim: Cold physical plasma (CPP) has emerged as an effective therapy in oncology by inducing cytotoxic effects in various cancer cells, including chondrosarcoma (CS), Ewing's sarcoma (ES), and osteosarcoma (OS). The current study investigated the impact of CPP on cell motility in CS (CAL-78), ES (A673), and OS (U2-OS) cell lines, focusing on the actin cytoskeleton. Materials and Methods: The CASY Cell Counter and Analyzer was used to study cell proliferation and determine the optimal concentrations of fetal calf serum to maintain viability without stimulation of cell proliferation. CellTiter-BlueCell viability assay was used to determine the effects of CPP on the viability of bone sarcoma cells. The Radius assay was used to determine cell migration. Staining for Deoxyribonuclease I, G-actin, and F-actin was used to assay for the effects on the cytoskeleton. Results: Reductions in cell viability and motility were observed across all cell lines following CPP treatment. CPP induced changes in the actin cytoskeleton, leading to decreased cell motility. Conclusion: CPP effectively reduces the motility of bone sarcoma cells by altering the actin cytoskeleton. These findings underscore CPP's potential as a therapeutic tool for bone sarcomas and highlight the need for further research in this area. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Proximal Femoral Replacement

Author

Kenanidis, Eustathios, Tsiridis, Eleftherios, Viste, Anthony, Taunton, Michael J., Abdel, Mathew P., Murilev, Valeriy, Rukin, Yaroslav, Tikhilov, Rashid, Wassilew, Georgi I., and Tsiridis, Eleftherios, editor

Published
2018
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44. Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Author

Durek, Pawel, Nordström, Karl, Gasparoni, Gilles, Salhab, Abdulrahman, Kressler, Christopher, de Almeida, Melanie, Bassler, Kevin, Ulas, Thomas, Schmidt, Florian, Xiong, Jieyi, Glažar, Petar, Klironomos, Filippos, Sinha, Anupam, Kinkley, Sarah, Yang, Xinyi, Arrigoni, Laura, Amirabad, Azim Dehghani, Ardakani, Fatemeh Behjati, Feuerbach, Lars, Gorka, Oliver, Ebert, Peter, Müller, Fabian, Li, Na, Frischbutter, Stefan, Schlickeiser, Stephan, Cendon, Carla, Fröhler, Sebastian, Felder, Bärbel, Gasparoni, Nina, Imbusch, Charles D., Hutter, Barbara, Zipprich, Gideon, Tauchmann, Yvonne, Reinke, Simon, Wassilew, Georgi, Hoffmann, Ute, Richter, Andreas S., Sieverling, Lina, Chang, Hyun-Dong, Syrbe, Uta, Kalus, Ulrich, Eils, Jürgen, Brors, Benedikt, Manke, Thomas, Ruland, Jürgen, Lengauer, Thomas, Rajewsky, Nikolaus, Chen, Wei, Dong, Jun, Sawitzki, Birgit, Chung, Ho-Ryun, Rosenstiel, Philip, Schulz, Marcel H., Schultze, Joachim L., Radbruch, Andreas, Walter, Jörn, Hamann, Alf, and Polansky, Julia K.

Published
2016
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