111 results on '"Wasselius, Johan"'
Search Results
2. Evaluation of CINA® LVO artificial intelligence software for detection of large vessel occlusion in brain CT angiography
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Mellander, Helena, Hillal, Amir, Ullberg, Teresa, and Wassélius, Johan
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- 2024
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Catalog
3. Brain volume: An important determinant of functional outcome after acute ischemic stroke
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Schirmer, Markus D., Donahue, Kathleen L., Nardin, Marco J., Dalca, Adrian V., Giese, Anne-Katrin, Etherton, Mark R., Mocking, Steven J. T., McIntosh, Elissa C., Cole, John W., Holmegaard, Lukas, Jood, Katarina, Jimenez-Conde, Jordi, Kittner, Steven J., Lemmens, Robin, Meschia, James F., Rosand, Jonathan, Roquer, Jaume, Rundek, Tatjana, MD, Ralph L. Sacco, Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Stanne, Tara M., Vagal, Achala, Wasselius, Johan, Woo, Daniel, Bevan, Stephen, Heitsch, Laura, Phuah, Chia-Ling, MD, Daniel Strbian, Tatlisumak, Turgut, Levi, Christopher R., Attia, John, McArdle, Patrick F., Worrall, Bradford B., Wu, Ona, Jern, Christina, Lindgren, Arne, Maguire, Jane, Thijs, Vincent, and Rost, Natalia S. more...
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Quantitative Biology - Neurons and Cognition - Abstract
Objective: To determine whether brain volume is associated with functional outcome after acute ischemic stroke (AIS). Methods: We analyzed cross-sectional data of the multi-site, international hospital-based MRI-GENetics Interface Exploration (MRI-GENIE) study (July 1, 2014- March 16, 2019) with clinical brain magnetic resonance imaging (MRI) obtained on admission for index stroke and functional outcome assessment. Post-stroke outcome was determined using the modified Rankin Scale (mRS) score (0-6; 0: asymptomatic; 6 death) recorded between 60-190 days after stroke. Demographics and other clinical variables including acute stroke severity (measured as National Institutes of Health Stroke Scale score), vascular risk factors, and etiologic stroke subtypes (Causative Classification of Stroke) were recorded during index admission. Results: Utilizing the data from 912 acute ischemic stroke (AIS) patients (65+/-15 years of age, 58% male, 57% history of smoking, and 65% hypertensive) in a generalized linear model, brain volume (per 155.1cm^3 ) was associated with age (beta -0.3 (per 14.4 years)), male sex (beta 1.0) and prior stroke (beta -0.2). In the multivariable outcome model, brain volume was an independent predictor of mRS (beta -0.233), with reduced odds of worse long-term functional outcomes (OR: 0.8, 95% CI 0.7-0.9) in those with larger brain volumes. Conclusions: Larger brain volume quantified on clinical MRI of AIS patients at time of stroke purports a protective mechanism. The role of brain volume as a prognostic, protective biomarker has the potential to forge new areas of research and advance current knowledge of mechanisms of post-stroke recovery. more...
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- 2020
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4. Comparison of image quality between a novel mobile CT scanner and current generation stationary CT scanners
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Andersson, Henrik, Tamaddon, Ashkan, Malekian, Mazdak, Ydström, Kristina, Siemund, Roger, Ullberg, Teresa, and Wasselius, Johan
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- 2023
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5. Metal artifact reduction by virtual monoenergetic reconstructions from spectral brain CT
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Mellander, Helena, Fransson, Veronica, Ydström, Kristina, Lätt, Jimmy, Ullberg, Teresa, Wassélius, Johan, and Ramgren, Birgitta
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- 2023
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6. Incidence of intracranial hemorrhagic complications after anterior circulation endovascular thrombectomy in relation to occlusion site: a nationwide observational register study.
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Hall, Emma, Ullberg, Teresa, Andsberg, Gunnar, and Wasselius, Johan
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INTRACRANIAL hemorrhage ,RISK assessment ,RESEARCH funding ,SCIENTIFIC observation ,ENDOVASCULAR surgery ,DESCRIPTIVE statistics ,CEREBRAL arteries ,SURGICAL complications ,THROMBECTOMY ,STROKE ,SURGICAL site ,DISEASE risk factors - Abstract
Background Intracranial hemorrhage (ICH) is a potentially severe complication of endovascular thrombectomy (EVT). However, the relationship between the incidence and severity of ICH and vascular occlusion location is not well described. Objective To present a comprehensive analysis of subtypes of ICHs and their relationship to the occlusion site following EVT in the anterior circulation. Methods All patients with anterior circulation vessel occlusion stroke (internal carotid (ICA) and middle cerebral artery's first (M1) and later segments (M2 and beyond)) registered in the two Swedish national quality registers for stroke care and endovascular therapy during 2015-2020 were included. Hemorrhagic complications identified on imaging within 36 hours post-EVT were classified according to Heidelberg Bleeding Classification and further divided into symptomatic (sICH) or non-symptomatic (non-sICH). Results Of the 3077 patients, ICH frequency was 24.2%, which included 4.5% sICH. Subarachnoid hemorrhage (SAH) was the most frequent subtype of hemorrhage (10.9%). The hemorrhagic subtypes differed significantly by occlusion site, but the frequency of any bleed did not. EVT performed in and beyond the M2 more often resulted in SAH, frequently classified as non-sICH. EVT performed in the ICA was associated with more severe hemorrhages, such as intraventricular and large parenchymal hematomas, that were more often classified as sICH. Conclusion In this nationwide unselected EVT cohort we found that ICH severity significantly differed between different vessel occlusion sites. [ABSTRACT FROM AUTHOR] more...
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- 2024
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7. Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke
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Bretzner, Martin, Bonkhoff, Anna K, Schirmer, Markus D., Hong, Sungmin, Dalca, Adrian, Donahue, Kathleen, Giese, Anne-Katrin, Etherton, Mark R, Rist, Pamela M, Nardin, Marco, Regenhardt, Robert W, Leclerc, Xavier, Lopes, Renaud, Gautherot, Morgan, Wang, Clinton, Benavente, Oscar R, Cole, John W., Donatti, Amanda, Griessenauer, Christoph, Heitsch, Laura, Holmegaard, Lukas, Jood, Katarina, Jimenez-Conde, Jordi, Kittner, Steven J, Lemmens, Robin, Levi, Christopher R, McArdle, Patrick F, McDonough, Caitrin W., Meschia, James F, Phuah, Chia-Ling, Rolfs, Arndt, Ropele, Stefan, Rosand, Jonathan, Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Sousa, Alessandro, Stanne, Tara M, Strbian, Daniel, Tatlisumak, Turgut, Thijs, Vincent, Vagal, Achala, Wasselius, Johan, Woo, Daniel, Wu, Ona, Zand, Ramin, Worrall, Bradford B, Maguire, Jane, Lindgren, Arne G, Jern, Christina, Golland, Polina, Kuchcinski, Grégory, and Rost, Natalia S more...
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- 2022
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8. Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome
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Bonkhoff, Anna K, Hong, Sungmin, Bretzner, Martin, Schirmer, Markus D., Regenhardt, Robert W, Arsava, E. Murat, Donahue, Kathleen, Nardin, Marco, Dalca, Adrian, Giese, Anne-Katrin, Etherton, Mark R, Hancock, Brandon L., Mocking, Steven J.T., McIntosh, Elissa, Attia, John, Benavente, Oscar, Cole, John W., Donatti, Amanda, Griessenauer, Christoph, Heitsch, Laura, Holmegaard, Lukas, Jood, Katarina, Jimenez-Conde, Jordi, Kittner, Steven, Lemmens, Robin, Levi, Christopher, McDonough, Caitrin W., Meschia, James, Phuah, Chia-Ling, Rolfs, Arndt, Ropele, Stefan, Rosand, Jonathan, Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Soederholm, Martin, Sousa, Alessandro, Stanne, Tara M, Strbian, Daniel, Tatlisumak, Turgut, Thijs, Vincent, Vagal, Achala, Wasselius, Johan, Woo, Daniel, Zand, Ramin, McArdle, Patrick, Worrall, Bradford B, Jern, Christina, Lindgren, Arne G, Maguire, Jane, Golland, Polina, Bzdok, Danilo, Wu, Ona, and Rost, Natalia S more...
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- 2022
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9. Classifications of atherosclerotic plaque components with T1 and T2* mapping in 11.7 T MRI
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Truong, My, Lennartsson, Finn, Bibic, Adnan, Sundius, Lena, Persson, Ana, Siemund, Roger, In’t Zandt, René, Goncalves, Isabel, and Wassélius, Johan
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- 2021
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10. Diagnostic accuracy and radiological validation of intracerebral hemorrhage diagnosis in the Swedish Stroke Register (Riksstroke).
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Sultani, Gabriella, Hillal, Amir, Ramgren, Birgitta, Apostolaki‐Hansson, Trine, Norrving, Bo, Wasselius, Johan, and Ullberg, Teresa
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INTRACRANIAL hemorrhage ,CEREBRAL hemorrhage ,STROKE ,SUBARACHNOID hemorrhage ,AGE groups - Abstract
Background and purpose: National quality registries for stroke care operate under the assumption that the included patients are correctly diagnosed. We aimed to validate the clinical diagnosis of spontaneous intracerebral hemorrhage (ICH) in Riksstroke (RS) by evaluating radiological data from a large, unselected ICH population. Methods: We conducted a retrospective, multicenter study including all ICH patients registered in RS between 2016 and 2020 residing in Skåne County in Sweden (1.41 million inhabitants). Radiological data from first imaging were evaluated for the presence of spontaneous ICH. Other types of bleeds were registered if a spontaneous ICH was not identified on imaging. The radiological evaluation was independently performed by one radiology fellow and one senior neuroradiologist. Results: Between 2016 and 2020, 1784 ICH cases were registered in RS, of which 1655 (92.8%) had a radiological diagnosis consistent with spontaneous ICH. In the 129 (7.2%) remaining cases, the radiological diagnosis was instead traumatic bleed (n = 80), subarachnoid hemorrhage (n = 15), brain tumor bleed (n = 14), ischemic lesion with hemorrhagic transformation (n = 14), ischemic lesion (n = 3), or no bleed at all (n = 3). There was a higher degree of incorrect coding in the older age groups. Conclusion: At radiological evaluation, 92.8% of ICH diagnoses in RS were consistent with spontaneous ICH, yielding a high rate of agreement that strengthens the validity of the diagnostic accuracy in the register, justifying the use of high coverage quality register data for epidemiological purposes. The most common coding error was traumatic bleeds that were classified as spontaneous ICH. [ABSTRACT FROM AUTHOR] more...
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- 2024
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11. Small vessel disease in primary familial brain calcification with novel truncating PDGFB variants
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Yektay Farahmand, Maha, primary, Wasselius, Johan, additional, Englund, Elisabet, additional, Braverman, Irwin, additional, Puschmann, Andreas, additional, and Ilinca, Andreea, additional
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- 2024
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12. Iterative metal artifact reduction in aortic CTA after Onyx®-embolization
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Lehti, Leena, Söderberg, Marcus, Mellander, Helena, and Wassélius, Johan
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- 2020
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13. The use of accelerometer bracelets to evaluate arm motor function over a stroke rehabilitation period – an explorative observational study.
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Finn, Eric Lyckegård, Carlsson, Håkan, Ericson, Petter, Åström, Kalle, Brogårdh, Christina, and Wasselius, Johan
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WRIST ,STROKE rehabilitation ,ACCELEROMETERS ,MOTORS ,BRACELETS ,ACCELEROMETRY ,SCIENTIFIC observation ,REHABILITATION - Abstract
Background: Assessments of arm motor function are usually based on clinical examinations or self-reported rating scales. Wrist-worn accelerometers can be a good complement to measure movement patterns after stroke. Currently there is limited knowledge of how accelerometry correlate to clinically used scales. The purpose of this study was therefore to evaluate the relationship between intermittent measurements of wrist-worn accelerometers and the patient's progression of arm motor function assessed by routine clinical outcome measures during a rehabilitation period. Methods: Patients enrolled in in-hospital rehabilitation following a stroke were invited. Included patients were asked to wear wrist accelerometers for 24 h at the start (T1) and end (T2) of their rehabilitation period. On both occasions arm motor function was assessed by the modified Motor Assessment Scale (M_MAS) and the Motor Activity Log (MAL). The recorded accelerometry was compared to M_MAS and MAL. Results: 20 patients were included, of which 18 completed all measurements and were therefore included in the final analysis. The resulting Spearman's rank correlation coefficient showed a strong positive correlation between measured wrist acceleration in the affected arm and M-MAS and MAL values at T1, 0.94 (p < 0.05) for M_MAS and 0.74 (p < 0.05) for the MAL values, and a slightly weaker positive correlation at T2, 0.57 (p < 0.05) for M_MAS and 0.46 − 0.45 (p = 0.06) for the MAL values. However, no correlation was seen for the difference between the two sessions. Conclusions: The results confirm that the wrist acceleration can differentiate between the affected and non-affected arm, and that there is a positive correlation between accelerometry and clinical measures. Many of the patients did not change their M-MAS or MAL scores during the rehabilitation period, which may explain why no correlation was seen for the difference between measurements during the rehabilitation period. Further studies should include continuous accelerometry throughout the rehabilitation period to reduce the impact of day-to-day variability. [ABSTRACT FROM AUTHOR] more...
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- 2024
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14. White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts – The MRI-GENIE study
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Schirmer, Markus D., Dalca, Adrian V., Sridharan, Ramesh, Giese, Anne-Katrin, Donahue, Kathleen L., Nardin, Marco J., Mocking, Steven J.T., McIntosh, Elissa C., Frid, Petrea, Wasselius, Johan, Cole, John W., Holmegaard, Lukas, Jern, Christina, Jimenez-Conde, Jordi, Lemmens, Robin, Lindgren, Arne G., Meschia, James F., Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Thijs, Vincent, Woo, Daniel, Vagal, Achala, Xu, Huichun, Kittner, Steven J., McArdle, Patrick F., Mitchell, Braxton D., Rosand, Jonathan, Worrall, Bradford B., Wu, Ona, Golland, Polina, and Rost, Natalia S. more...
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- 2019
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15. Detection of Perfusion Deficits in Multiphase Computed Tomography Angiography—A Stroke Imaging Technique Based on Iodine Mapping on Spectral Computed Tomography: Initial Findings
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Fransson, Veronica, Mellander, Helena, Wasselius, Johan, and Ydström, Kristina
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- 2021
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16. O35/335 Factors associated with successful recanalization in patients with acute ischemic stroke treated with endovascular thrombectomy – a nationwide register-based observational study
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Wasselius, Johan, primary, Hall, Emma, additional, Ramgren, Birgitta, additional, Andersson, Tommy, additional, and Ullberg, Teresa, additional
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- 2023
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17. White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype
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Giese, Anne-Katrin, Schirmer, Markus D., Dalca, Adrian V., Sridharan, Ramesh, Donahue, Kathleen L., Nardin, Marco, Irie, Robert, McIntosh, Elissa C., Mocking, Steven J.T., Xu, Huichun, Cole, John W., Giralt-Steinhauer, Eva, Jimenez-Conde, Jordi, Jern, Christina, Kleindorfer, Dawn O., Lemmens, Robin, Wasselius, Johan, Lindgren, Arne, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Thijs, Vincent, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., McArdle, Patrick F., Mitchell, Braxton D., Rosand, Jonathan, Meschia, James F., Wu, Ona, Golland, Polina, and Rost, Natalia S. more...
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- 2020
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18. Big Data Approaches to Phenotyping Acute Ischemic Stroke Using Automated Lesion Segmentation of Multi-Center Magnetic Resonance Imaging Data
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Wu, Ona, Winzeck, Stefan, Giese, Anne-Katrin, Hancock, Brandon L., Etherton, Mark R., Bouts, Mark J.R.J., Donahue, Kathleen, Schirmer, Markus D., Irie, Robert E., Mocking, Steven J.T., McIntosh, Elissa C., Bezerra, Raquel, Kamnitsas, Konstantinos, Frid, Petrea, Wasselius, Johan, Cole, John W., Xu, Huichun, Holmegaard, Lukas, Jiménez-Conde, Jordi, Lemmens, Robin, Lorentzen, Eric, McArdle, Patrick F., Meschia, James F., Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Stanne, Tara M., Thijs, Vincent, Vagal, Achala, Woo, Daniel, Bevan, Stephen, Kittner, Steven J., Mitchell, Braxton D., Rosand, Jonathan, Worrall, Bradford B., Jern, Christina, Lindgren, Arne G., Maguire, Jane, and Rost, Natalia S. more...
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- 2019
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19. Small vessel disease in primary familial brain calcification with novel truncating PDGFB variants.
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Farahmand, Maha Yektay, Wasselius, Johan, Englund, Elisabet, Braverman, Irwin, Puschmann, Andreas, and Ilinca, Andreea
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Introduction. Primary familial brain calcification (PFBC) is a neurodegenerative disease characterised by bilateral calcification in the brain, especially in the basal ganglia, leading to neurological and neuropsychiatric manifestations. White matter hyperintensities (WMH) have been described in patients with PFBC and pathogenic variants in the gene for platelet-derived growth factor beta polypeptide (PDGFB), suggesting a manifest cerebrovascular process. We present below the cases of two PFBC families with PDGFB variants and stroke or transient ischaemic attack (TIA) episodes. We examine the possible correlation between PFBC and vascular events as stroke/TIA, and evaluate whether signs for vascular disease in this condition are systemic or limited to the cerebral vessels. Material and methods. Two Swedish families with novel truncating PDGFB variants, p.Gln140* and p.Arg191*, are described clinically and radiologically. Subcutaneous capillary vessels in affected and unaffected family members were examined by light and electron microscopy. Results. All mutation carriers showed WMH and bilateral brain calcifications. The clinical presentations differed, with movement disorder symptoms dominating in family A, and psychiatric symptoms in family B. However, affected members of both families had stroke, TIA, and/or asymptomatic intracerebral ischaemic lesions. Only one of the patients had classical vascular risk factors. Skin microvasculature was normal. Conclusions. Patients with these PDGFB variants develop microvascular changes in the brain, but not the skin. PDGFB-related small vessel disease can manifest radiologically as cerebral haemorrhage or ischaemia, and may explain TIA or stroke in patients without other vascular risk factors. [ABSTRACT FROM AUTHOR] more...
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- 2024
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20. Accuracy of uncalibrated 2D digital subtraction angiography measurements on a novel biplane system compared to computed tomography angiography
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Landström, Lovisa, primary and Wasselius, Johan A, additional
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- 2023
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21. sj-docx-1-ine-10.1177_15910199231171656 - Supplemental material for Accuracy of uncalibrated 2D digital subtraction angiography measurements on a novel biplane system compared to computed tomography angiography
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Landström, Lovisa and Wasselius, Johan A
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FOS: Clinical medicine ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, sj-docx-1-ine-10.1177_15910199231171656 for Accuracy of uncalibrated 2D digital subtraction angiography measurements on a novel biplane system compared to computed tomography angiography by Lovisa Landstrom, and Johan A Wasselius in Interventional Neuroradiology more...
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- 2023
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22. Comparison of image quality between a novel mobile CT scanner and current generation stationary CT scanners
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Andersson, Henrik, primary, Tamaddon, Ashkan, additional, Malekian, Mazdak, additional, Ydström, Kristina, additional, Siemund, Roger, additional, Ullberg, Teresa, additional, and Wasselius, Johan, additional more...
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- 2022
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23. Design and rationale for examining neuroimaging genetics in ischemic stroke: The MRI-GENIE study
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Giese, Anne-Katrin, Schirmer, Markus D., Donahue, Kathleen L., Cloonan, Lisa, Irie, Robert, Winzeck, Stefan, Bouts, Mark J.R.J., McIntosh, Elissa C., Mocking, Steven J., Dalca, Adrian V., Sridharan, Ramesh, Xu, Huichun, Frid, Petrea, Giralt-Steinhauer, Eva, Holmegaard, Lukas, Roquer, Jaume, Wasselius, Johan, Cole, John W., McArdle, Patrick F., Broderick, Joseph P., Jimenez-Conde, Jordi, Jern, Christina, Kissela, Brett M., Kleindorfer, Dawn O., Lemmens, Robin, Lindgren, Arne, Meschia, James F., Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Thijs, Vincent, Woo, Daniel, Worrall, Bradford B., Kittner, Steven J., Mitchell, Braxton D., Rosand, Jonathan, Golland, Polina, Wu, Ona, and Rost, Natalia S. more...
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- 2017
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24. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
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Chauhan, Ganesh, Adams, Hieab H.H., Satizabal, Claudia L., Bis, Joshua C., Teumer, Alexander, Sargurupremraj, Muralidharan, Hofer, Edith, Trompet, Stella, Hilal, Saima, Smith, Albert Vernon, Jian, Xueqiu, Malik, Rainer, Traylor, Matthew, Pulit, Sara L., Amouyel, Philippe, Mazoyer, Bernard, Zhu, Yi-Cheng, Kaffashian, Sara, Schilling, Sabrina, Beecham, Gary W., Montine, Thomas J., Schellenberg, Gerard D., Kjartansson, Olafur, Guðnason, Vilmundur, Knopman, David S., Griswold, Michael E., Windham, B. Gwen, Gottesman, Rebecca F., Mosley, Thomas H., Schmidt, Reinhold, Saba, Yasaman, Schmidt, Helena, Takeuchi, Fumihiko, Yamaguchi, Shuhei, Nabika, Toru, Kato, Norihiro, Rajan, Kumar B., Aggarwal, Neelum T., De Jager, Philip L., Evans, Denis A., Psaty, Bruce M., Rotter, Jerome I., Rice, Kenneth, Lopez, Oscar L., Liao, Jiemin, Chen, Christopher, Cheng, Ching-Yu, Wong, Tien Y., Ikram, Mohammad K., van der Lee, Sven J., Amin, Najaf, Chouraki, Vincent, DeStefano, Anita L., Aparicio, Hugo J., Romero, Jose R., Maillard, Pauline, DeCarli, Charles, Wardlaw, Joanna M., Hernández, Maria del C. Valdés, Luciano, Michelle, Liewald, David, Deary, Ian J., Starr, John M., Bastin, Mark E., Muñoz Maniega, Susana, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, Uh, Hae-Won, Lemmens, Robin, Brodaty, Henry, Wright, Margaret J., Ames, David, Boncoraglio, Giorgio B., Hopewell, Jemma C., Beecham, Ashley H., Blanton, Susan H., Wright, Clinton B., Sacco, Ralph L., Wen, Wei, Thalamuthu, Anbupalam, Armstrong, Nicola J., Chong, Elizabeth, Schofield, Peter R., Kwok, John B., van der Grond, Jeroen, Stott, David J., Ford, Ian, Jukema, J. Wouter, Vernooij, Meike W., Hofman, Albert, Uitterlinden, André G., van der Lugt, Aad, Wittfeld, Katharina, Grabe, Hans J., Hosten, Norbert, von Sarnowski, Bettina, Völker, Uwe, Levi, Christopher, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie L.M., Rosand, Jonathan, Woo, Daniel, Cole, John W., Meschia, James F., Slowik, Agnieszka, Thijs, Vincent, Lindgren, Arne, Melander, Olle, Grewal, Raji P., Rundek, Tatjana, Rexrode, Kathy, Rothwell, Peter M., Arnett, Donna K., Jern, Christina, Johnson, Julie A., Benavente, Oscar R., Wasssertheil-Smoller, Sylvia, Lee, Jin-Moo, Wong, Quenna, Mitchell, Braxton D., Rich, Stephen S., McArdle, Patrick F., Geerlings, Mirjam I., van der Graaf, Yolanda, de Bakker, Paul I.W., Asselbergs, Folkert W., Srikanth, Velandai, Thomson, Russell, McWhirter, Rebekah, Moran, Chris, Callisaya, Michele, Phan, Thanh, Rutten-Jacobs, Loes C.A., Bevan, Steve, Tzourio, Christophe, Mather, Karen A., Sachdev, Perminder S., van Duijn, Cornelia M., Worrall, Bradford B., Dichgans, Martin, Kittner, Steven J., Markus, Hugh S., Ikram, Mohammad A., Fornage, Myriam, Launer, Lenore J., Seshadri, Sudha, Longstreth, W.T., Jr, Debette, Stéphanie, Almgren, Peter, Anderson, Christopher D., Arnett, Donna K., Attia, John, Ay, Hakan, Benavente, Oscar R., Bevan, Steve, Brown, Robert D., Bustamante, Mariana, Cheng, Yu-Ching, Cole, John W., Cotlarciuc, Ioana, Cruchaga, Carlos, de Bakker, Paul IW., Delavaran, Hossein, Dichgans, Martin, Engström, Gunnar, Fornage, Myriam, Grewal, Raji P., Heitsch, Laura, Holliday, Elizabeth, Ibanez, Laure, Ilinca, Andreea, Irvin, Marguerite R., Jackson, Rebecca D., Jern, Christina, Jimenez-Conde, Jordi, Johnson, Julie A., Jood, Katarina, Kissela, Brett M., Kittner, Steven J., Kleindorfer, Dawn O., Labovitz, Daniel, Laurie, Cathy C., Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher, Li, Linxin, Lindgren, Arne G., Maguire, Jane, Markus, Hugh S., McArdle, Patrick F., Melander, Olle, Meschia, James F., Mitchell, Braxton D., Müller-Nurasyid, Martina, Norrving, Bo, Peddareddygari, Leema Reddy, Pera, Joanna, Pulit, Sara L., Rexrode, Kathryn, Ribasés, Marta, Roquer, Jaume, Rost, Natalia S., Rothwell, Peter M., Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Soriano-Tárraga, Carolina, Stanne, Tara, Stauch, Konstantin, Stine, O C., Sudlow, Cathie LM., Thijs, Vincent N.S., Wasssertheil-Smoller, Sylvia, Weir, David, Williams, Stephen R., Wong, Quenna, Woo, Daniel, Worrall, Bradford B., Xu, Huichun, Seshadri, Sudha, Hyacinth, Hyacinth I, Marini, Sandro, Nyquist, Paul, Lewis, Cathryn, Hansen, Bjorn, Norrving, Bo, Rosand, Jonathan, Biffi, Alessandro, Kourkoulis, Christina, Anderson, Chris, Giese, Anne-Katrin, Sacco, Ralph, Sharma, Pankaj, Chung, Jong-Won, Kim, Gyeong-Moon, Lubitz, Steven, Bourcier, Romain, Howson, Joanna, Granata, Alessandra, Drazyk, Anna, Markus, Hugh, Wardlaw, Joanna, Mitchell, Braxton, Cole, John, Hopewell, Jemma, Walters, Robin, Turnbull, Iain, Worrall, Bradford, Bis, Josh, Reiner, Alex, Dhar, Raj, Heitsch, Laura, Lee, Jin-Moo, Prasad, Kameshwar, Sarnowski, Chloé, Aparicio, Hugo Javier, Yang, Qiong, Chasman, Daniel, Rexrode, Kathryn, Phuah, Chia-Ling, Liu, Guiyou, Elkind, Mitchell, Lange, Leslie, Rost, Natalia, James, Michael, Stewart, Jill, Vojinovic, Dina, Thijs, Vincent, Parati, Eugenio, Boncoraglio, Giorgio, Zand, Ramin, Bijlenga, Philippe, Selim, Magdy, Grond-Ginsbach, Caspar, Strbian, Daniel, Tomppo, Liisa, Sallinen, Hanne, Pfeiffer, Dorothea, Torres, Nuria, Barboza, Miguel, Laarman, Melanie, Carriero, Roberta, Holliday, Elizabeth, Jimenez-Conde, Jordi, Soriano, Carolina, Gill, Dipender, Debette, Stephanie, Mishra, Aniket, Wu, Jer-Yuarn, Ko, Tai-Ming, Bione, Silvia, Jood, Katarina, Tatlisumak, Turgut, Holmegaard, Lukas, Yue, Suo, bersano, Anna, Pera, Joanna, Slowik, Agnieszka, Levi, Christopher, Schlicht, Kristina, Lemmens, Robin, Ninomiya, Toshiharu, Oberstein, Saskia Lesnik, Lee, Tsong-Hai, Malik, Rainer, Dichgans, Martin, Lindgren, Arne, Wasselius, Johan, Drake, Mattias, Melander, Olle, Stenman, Martin, Ilinca, Andreea, Crawford, Katherine, Lena, Umme, Mateen, Farrah, Ay, Hakan, Wu, Ona, Schirmer, Markus, Cramer, Steve, Golland, Polina, Brown, Robert, Meschia, James, Ross, Owen A., Pare, Guillaume, Chong, Mike, Rundek, Tatjana, Gwinn, Katrina, Chen, Christopher, Koenig, Jim, Giralt, Eva, Saleheen, Danish, de Leeuw, Frank-Erik, Klijn, Karin, Kamatani, Yoichiro, Kubo, Michiaki, Okada, Yukinori, Pedersen, Annie, Olsson, Maja, Martín, Juan José, Xu, Huichun, Tan, Eng King, Frid, Petrea, Lee, Chaeyoung, Tregouet, David, Leung, Thomas, Choy, Richard, Jern, Christina, Loo, Keat Wei, Rinkel, Gabriel, Franca, Paulo, Cendes, Iscia, Carrera, Caty, Fernandez-Cadenas, Israel, Montaner, Joan, Kim, Helen, Owolabi, Mayowa, Sofat, Reecha, Bakker, Mark, Ruigrok, Ynte, Hauer, Allard, Pulit, Sara L., van der Laan, Sander W., Irvin, Ryan, Sargurupremraj, Murali, Pezzini, Alessandro, Abd-Allah, Foad, Liebeskind, David, Traylor, Matthew, Tan, Rhea, Danesh, John, Rutten-Jacobs, Loes, Donatti, Amanda, Avelar, Wagner, Broderick, Joseph, Woo, Daniel, Sudlow, Cathie, Rannikmae, Kristiina, McDonough, Caitrin Wheeler, van Agtmael, Tom, Walters, Matthew, Söderholm, Martin, Lorentzen, Erik, Olsson, Sandra, Stanne, Tara, Olsson, Martina, Akinyemi, Rufus, Cotlatciuc, Ioana, McArdle, Patrick, Dave, Tushar, Kittner, Steven, Attia, John, Faber, James E, Millwood, Iona, Márquez, Elsa Valdés, Mancuso, Michelangelo, Vibo, Riina, Korv, Janika, Maguire, Jane, Fornage, Myriam, Majersik, Jennifer, DeHavenon, Adam, Alexander, Matthew, Sale, Michele, Southerland, Andrew, Owens, Debra, Psaty, Bruce, Longstreth, W. T., Jr, Wolfe, Stacey Quintero, Langefeld, Carl, Cruchaga, Carlos, Konrad, Jan, Sheth, Kevin, Falcone, Guido, Donahue, Kathleen, Simpkins, Alexis N, Liang Byorn, Tan Wei, Chan, Bernard, Clatworthy, Phil, Florez, Jose, Harshfield, Eric, Hozawa, Atsushi, Hsu, Chung, Hu, Chaur-Jong, Ibanez, Laure, Ihara, Masafumi, Lange, Marcos, Lee, Soo Ji, Lee, I-Hui, Musolino, Patricia, Nakatomi, Hirofumi, Park, Kwang-Yeol, Rich, Stephen S, Riley, Chris, Sung, Joohon, Suzuki, Hideaki, Vo, Katie, Washida, Kazuo, Ibenez, Laura Garcia, Slowik, Agnieszka, Hofman, Albert, Algra, Ale, Reiner, Alex P, Doney, Alexander S F, Gschwendtner, Andreas, Ilinca, Andreea, Giese, Anne-Katrin, Lindgren, Arne, Vicente, Astrid M, Norrving, Bo, Nordestgaard, Børge G, Mitchell, Braxton D, Worrall, Bradford B, Psaty, Bruce M, Carty, Cara L, Sudlow, Cathie, Anderson, Christopher D, Levi, Christopher, Satizabal, Claudia L, Palmer, Colin N A, Gamble, Dale M, Woo, Daniel, Saleheen, Danish, Ringelstein, E Bernd, Valdimarsson, Einar, Holliday, Elizabeth, Davies, Gail, Chauhan, Ganesh, Pasterkamp, Gerard, Boncoraglio, Giorgio, Kuhlenbäumer, Gregor, Thorleifsson, Gudmar, Falcone, Guido J, Pare, Guillame, Schmidt, Helena, Delavaran, Hossein, Markus, Hugh S, Aparicio, Hugo J, Deary, Ian, Cotlarciuc, Ioana, Fernandez-Cadenas, Israel, Meschia, James, Hopewell, Jemma C, Liu, Jingmin, Montaner, Joan, Pera, Joanna, Cole, John, Attia, John R, Rosand, Jonathan, Ferro, Jose M, Bis, Joshua, Furie, Karen, Stefansson, Kari, Berger, Klaus, Kostulas, Konstantinos, Rannikmae, Kristina, Ikram, M Arfan, Benn, Marianne, Dichgans, Martin, Farrall, Martin, Pandolfo, Massimo, Traylor, Matthew, Walters, Matthew, Sale, Michele, Nalls, Mike, Fornage, Myriam, van Zuydam, Natalie R, Sharma, Pankaj, Abrantes, Patricia, de Bakker, Paul IW, Higgins, Peter, Lichtner, Peter, Rothwell, Peter M, Amouyel, Philippe, Yang, Qiong, Malik, Rainer, Schmidt, Reinhold, Clarke, Robert, Lemmens, Robin, van der Laan, Sander W, Pulit, Sara L, Abboud, Sherine, Oliveira, Sofia A, Gretarsdottir, Solveig, Debette, Stephanie, Williams, Stephen R, Bevan, Steve, Kittner, Steven J, Seshadri, Sudha, Mosley, Thomas, Battey, Thomas WK, Tatlisumak, Turgut, Thorsteinsdottir, Unnur, Thijs, Vincent NS, Longstreth, W T, Zhao, Wei, Chen, Wei-Min, Cheng, Yu-Ching, Albert, Marilyn S., Albin, Roger L., Apostolova, Liana G., Arnold, Steven E., Asthana, Sanjay, Atwood, Craig S., Baldwin, Clinton T., Barmada, M. Michael, Barnes, Lisa L., Barral, Sandra, Beach, Thomas G., Becker, James T., Beecham, Gary W., Beekly, Duane, Bennett, David A., Bigio, Eileen H., Bird, Thomas D., Blacker, Deborah, Boeve, Bradley F., Boxer, Adam, Burke, James R., Burns, Jeffrey M., Buxbaum, Joseph D., Byrd, Goldie S., Cai, Guiqing, Cairns, Nigel J., Cantwell, Laura B., Cao, Chuanhai, Carlsson, Cynthia M., Carney, Regina M., Carrasquillo, Minerva M., Carroll, Steven L., Chui, Helena C., Clark, David G., Cribbs, David H., Crocco, Elizabeth A., Cruchaga, Carlos, De Jager, Philip L., DeCarli, Charles, Demirci, F. Yesim, Dick, Malcolm, Dickson, Dennis W., Duara, Ranjan, Ertekin-Taner, Nilufer, Evans, Denis A., Faber, Kelley M., Fallin, M. Daniele, Fallon, Kenneth B., Fardo, David W., Farlow, Martin R., Farrer, Lindsay A., Ferris, Steven, Foroud, Tatiana M., Frosch, Matthew P., Galasko, Douglas R., Gearing, Marla, Geschwind, Daniel H., Ghetti, Bernardino, Gilbert, John R., Go, Rodney C.P., Goate, Alison M., Graff-Radford, Neill R., Green, Robert C., Griffith, Patrick, Growdon, John H., Haines, Jonathan L., Hakonarson, Hakon, Hamilton, Ronald L., Hamilton-Nelson, Kara L., Haroutunian, Vahram, Harrell, Lindy E., Honig, Lawrence S., Huebinger, Ryan M., Hulette, Christine M., Hyman, Bradley T., Jicha, Gregory A., Jin, Lee-Way, Jun, Gyungah, Kamboh, M. Ilyas, Karydas, Anna, Kauwe, John S.K., Kaye, Jeffrey A., Kim, Ronald, Kowall, Neil W., Kramer, Joel H., Kukull, Walter A., Kunkle, Brian W., LaFerla, Frank M., Lah, James J., Lang-Walker, Rosalyn, Larson, Eric B., Leverenz, James B., Levey, Allan I., Li, Ge, Lieberman, Andrew P., Logue, Mark W., Lopez, Oscar L., Lunetta, Kathryn L., Lyketsos, Constantine G., Mack, Wendy J., Manly, Jennifer J., Marson, Daniel C., Martin, Eden R., Martiniuk, Frank, Mash, Deborah C., Masliah, Eliezer, Mayeux, Richard, McKee, Ann C., Mesulam, Marsel, Miller, Bruce L., Miller, Carol A., Miller, Joshua W., Montine, Thomas J., Morris, John C., Murrell, Jill R., Naj, Adam C., Obisesan, Thomas O., Olichney, John M., Pankratz, Vernon S., Parisi, Joseph E., Partch, Amanda, Paulson, Henry L., Pericak-Vance, Margaret A., Perry, William, Peskind, Elaine, Petersen, Ronald C., Pierce, Aimee, Poon, Wayne W., Potter, Huntington, Quinn, Joseph F., Raj, Ashok, Raj, Towfique, Raskind, Murray, Reiman, Eric M., Reisberg, Barry, Reitz, Christiane, Ringman, John M., Roberson, Erik D., Rosen, Howard J., Rosenberg, Roger N., Sager, Mark A., Sano, Mary, Saykin, Andrew J., Schellenberg, Gerard D., Schneider, Julie A., Schneider, Lon S., Seeley, William W., Smith, Amanda G., Sonnen, Joshua A., Spina, Salvatore, Stern, Robert A., Swerdlow, Russell H., Tanzi, Rudolph E., Thornton-Wells, Tricia A., Trojanowski, John Q., Troncoso, Juan C., Tsuang, Debby W., Valladares, Otto, Van Deerlin, Vivianna M., Van Eldik, Linda J., Vardarajan, Badri N., Vinters, Harry V., Vonsattel, Jean Paul, Wang, Li-San, Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Williamson, Jennifer, Wingo, Thomas S., Wishnek, Sarah, Woltjer, Randall L., Wright, Clinton B., Younkin, Steven G., Yu, Chang-En, Yu, Lei, Chauhan, Ganesh, Chu, Audrey Y., Fornage, Myriam, Bis, Joshua C., Havulinna, Aki S., Sargurupremraj, Muralidharan, Smith, Albert Vernon, Adams, Hieab H.H., Choi, Seung Hoan, Trompet, Stella, Garcia, Melissa E., Manichaikul, Ani, Teumer, Alexander, Gustafsson, Stefan, Bartz, Traci M., Bellenguez, Céline, Vidal, Jean Sebastien, Jian, Xueqiu, Kjartansson, Olafur, Wiggins, Kerri L., Satizabal, Claudia L., Xue, Flora, Ripatti, Samuli, Liu, Yongmei, Deelen, Joris, Hoed, Marcel den, Heckbert, Susan R., Rice, Kenneth, Smith, Nicholas L., Wong, Quenna, Aparicio, Hugo J., Buring, Julie E., Ridker, Paul M, Berr, Claudine, Dartigues, Jean-François, Hamsten, Anders, Magnusson, Patrik K., Pedersen, Nancy L., Lannfelt, Lars, Lind, Lars, Lindgren, Cecilia M., Morris, Andrew P., Hofman, Albert, Koudstaal, Peter J., Portegies, Marileen LP., Uitterlinden, André G., de Craen, Anton JM, Ford, Ian, Jukema, J. Wouter, Stott, David J, Allen, Norrina B., Sale, Michele M., Johnson, Andrew D, Bennett, David A., De Jager, Philip L., White, Charles C., Grabe, Hans Jörgen, Paulista Markus, Marcello Ricardo, Lopez, Oscar L, Rotter, Jerome I., Nalls, Michael A., Gottesman, Rebecca F., Griswold, Michael E., Knopman, David S., Windham, B. Gwen, Beiser, Alexa, Vartiainen, Erkki, French, Curtis R., Kurth, Tobias, Psaty, Bruce M., Harris, Tamara B., Rich, Stephen S, deStefano, Anita L., Schmidt, Carsten Oliver, Salomaa, Veikko, Mosley, Thomas H., Ingelsson, Erik, van Duijn, Cornelia M., Tzourio, Christophe, Launer, Lenore J, Ikram, M. Arfan, Chasman, Daniel I., Longstreth, W. T., Jr, Seshadri, Sudha, Debette, Stéphanie, Verhaaren, Benjamin F.J., Debette, Stéphanie, Bis, Joshua C., Smith, Jennifer A., Ikram, M. Kamran, Adams, Hieab H., Beecham, Ashley H., Rajan, Kumar B., Lopez, Lorna M., Barral, Sandra, van Buchem, Mark A., van der Grond, Jeroen, Smith, Albert V., Hegenscheid, Katrin, Aggarwal, Neelum T., de Andrade, Mariza, Atkinson, Elizabeth J., Beekman, Marian, Beiser, Alexa S., Blanton, Susan H., Boerwinkle, Eric, Brickman, Adam M., Bryan, R. Nick, Chauhan, Ganesh, Chen, Christopher P.L.H., Chouraki, Vincent, de Craen, Anton J.M., Crivello, Fabrice, Deary, Ian J., Deelen, Joris, De Jager, Philip L., Dufouil, Carole, Elkind, Mitchell S.V., Evans, Denis A., Freudenberger, Paul, Gottesman, Rebecca F., Guðnason, Vilmundur, Habes, Mohamad, Heckbert, Susan R., Heiss, Gerardo, Hilal, Saima, Hofer, Edith, Hofman, Albert, Ibrahim-Verbaas, Carla A., Knopman, David S., Lewis, Cora E., Liao, Jiemin, Liewald, David C.M., Luciano, Michelle, van der Lugt, Aad, Martinez, Oliver O., Mayeux, Richard, Mazoyer, Bernard, Nalls, Mike, Nauck, Matthias, Niessen, Wiro J., Oostra, Ben A., Psaty, Bruce M., Rice, Kenneth M., Rotter, Jerome I., von Sarnowski, Bettina, Schmidt, Helena, Schreiner, Pamela J., Schuur, Maaike, Sidney, Stephen S., Sigurdsson, Sigurdur, Slagboom, P. Eline, Stott, David J.M., van Swieten, John C., Teumer, Alexander, Töglhofer, Anna Maria, Traylor, Matthew, Trompet, Stella, Turner, Stephen T., Tzourio, Christophe, Uh, Hae-Won, Uitterlinden, André G., Vernooij, Meike W., Wang, Jing J., Wong, Tien Y., Wardlaw, Joanna M., Windham, B. Gwen, Wittfeld, Katharina, Wolf, Christiane, Wright, Clinton B., Yang, Qiong, Zhao, Wei, Zijdenbos, Alex, Jukema, J. Wouter, Sacco, Ralph L., Kardia, Sharon L.R., Amouyel, Philippe, Mosley, Thomas H., Longstreth, W. T., Jr, DeCarli, Charles C., van Duijn, Cornelia M., Schmidt, Reinhold, Launer, Lenore J., Grabe, Hans J., Seshadri, Sudha S., Ikram, M. Arfan, Fornage, Myriam, Bis, Joshua C., Kavousi, Maryam, Franceschini, Nora, Isaacs, Aaron, Abecasis, Gonçalo R, Schminke, Ulf, Post, Wendy, Smith, Albert V., Cupples, L. Adrienne, Markus, Hugh S, Schmidt, Reinhold, Huffman, Jennifer E., Lehtimäki, Terho, Baumert, Jens, Münzel, Thomas, Heckbert, Susan R., Dehghan, Abbas, North, Kari, Oostra, Ben, Bevan, Steve, Stoegerer, Eva-Maria, Hayward, Caroline, Raitakari, Olli, Meisinger, Christa, Schillert, Arne, Sanna, Serena, Völzke, Henry, Cheng, Yu-Ching, Thorsson, Bolli, Fox, Caroline S., Rice, Kenneth, Rivadeneira, Fernando, Nambi, Vijay, Halperin, Eran, Petrovic, Katja E., Peltonen, Leena, Wichmann, H. Erich, Schnabel, Renate B., Dörr, Marcus, Parsa, Afshin, Aspelund, Thor, Demissie, Serkalem, Kathiresan, Sekar, Reilly, Muredach P., Taylor, Kent, Uitterlinden, Andre, Couper, David J., Sitzer, Matthias, Kähönen, Mika, Illig, Thomas, Wild, Philipp S., Orru, Marco, Lüdemann, Jan, Shuldiner, Alan R., Eiriksdottir, Gudny, White, Charles C., Rotter, Jerome I., Hofman, Albert, Seissler, Jochen, Zeller, Tanja, Usala, Gianluca, Ernst, Florian, Launer, Lenore J., DʼAgostino, Ralph B., Sr, OʼLeary, Daniel H., Ballantyne, Christie, Thiery, Joachim, Ziegler, Andreas, Lakatta, Edward G., Chilukoti, Ravi Kumar, Harris, Tamara B., Wolf, Philip A., Psaty, Bruce M., Polak, Joseph F, Li, Xia, Rathmann, Wolfgang, Uda, Manuela, Boerwinkle, Eric, Klopp, Norman, Schmidt, Helena, Wilson, James F, Viikari, Jorma, Koenig, Wolfgang, Blankenberg, Stefan, Newman, Anne B., Witteman, Jacqueline, Heiss, Gerardo, van Duijn, Cornelia, Scuteri, Angelo, Homuth, Georg, Mitchell, Braxton D., Gudnason, Vilmundur, and O’Donnell, Christopher J. more...
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- 2019
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25. Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics
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Bonkhoff, Anna K., primary, Ullberg, Teresa, additional, Bretzner, Martin, additional, Hong, Sungmin, additional, Schirmer, Markus D., additional, Regenhardt, Robert W., additional, Donahue, Kathleen L., additional, Nardin, Marco J., additional, Dalca, Adrian V., additional, Giese, Anne-Katrin, additional, Etherton, Mark R., additional, Hancock, Brandon L., additional, Mocking, Steven J. T., additional, McIntosh, Elissa C., additional, Attia, John, additional, Cole, John W., additional, Donatti, Amanda, additional, Griessenauer, Christoph J., additional, Heitsch, Laura, additional, Holmegaard, Lukas, additional, Jood, Katarina, additional, Jimenez-Conde, Jordi, additional, Kittner, Steven J., additional, Lemmens, Robin, additional, Levi, Christopher R., additional, McDonough, Caitrin W., additional, Meschia, James F., additional, Phuah, Chia-Ling, additional, Ropele, Stefan, additional, Rosand, Jonathan, additional, Roquer, Jaume, additional, Rundek, Tatjana, additional, Sacco, Ralph L., additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Sousa, Alessandro, additional, Stanne, Tara M., additional, Strbian, Daniel, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Vagal, Achala, additional, Woo, Daniel, additional, Zand, Ramin, additional, McArdle, Patrick F., additional, Worrall, Bradford B., additional, Jern, Christina, additional, Lindgren, Arne G., additional, Maguire, Jane, additional, Wu, Ona, additional, Frid, Petrea, additional, Rost, Natalia S., additional, and Wasselius, Johan, additional more...
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- 2022
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26. The relevance of rich club regions for functional outcome post-stroke is enhanced in women
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Bonkhoff, Anna, primary, Schirmer, Markus, additional, Bretzner, Martin, additional, Hong, Sungmin, additional, Regenhardt, Robert, additional, Donahue, Kathleen, additional, Nardin, Marco, additional, Dalca, Adrian, additional, Giese, Anne-Katrin, additional, Etherton, Mark, additional, Hancock, Brandon, additional, Mocking, Steven, additional, McIntosh, Elissa, additional, Attia, John, additional, Cole, John, additional, Donatti, Amanda, additional, Griessenaur, Christoph, additional, Heitsch, Laura, additional, Holmegaard, Lukas, additional, Jood, Katharina, additional, Jimenez-Conde, Jordi, additional, Kittner, Steven, additional, Lemmens, Robin, additional, Levi, Christopher, additional, McDonough, Caitrin, additional, Meschia, James, additional, Phuah, Chia-Ling, additional, Ropele, Stefan, additional, Rosand, Jonathan, additional, Roquer, Jaume, additional, Rundek, Tatjana, additional, Sacco, Ralph, additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Sousa, Alessandro, additional, Stanne, Tara, additional, Strbian, Daniel, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Vagal, Achala, additional, Wasselius, Johan, additional, Woo, Daniel, additional, Zand, Ramin, additional, McArdle, Patrick, additional, Worrall, Bradford, additional, Jern, Christina, additional, Lindgren, Arne, additional, Maguire, Jane, additional, Wu, Ona, additional, and Rost, Natalia, additional more...
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- 2022
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27. Sex-specific lesion pattern of functional outcomes after stroke
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Bonkhoff, Anna K., Bretzner, Martin, Hong, Sungmin, Schirmer, Markus D., Cohen, Alexander, Regenhardt, Robert W., Donahue, Kathleen L., Nardin, Marco J., Dalca, Adrian Vasile, Giese, Anne-Katrin, Etherton, Mark R., Hancock, Brandon L., Mocking, Steven J. T., McIntosh, Elissa C., Attia, John, Benavente, Oscar R., Bevan, Stephen, Cole, John W., Donatti, Amanda, Griessenauer, Christoph J., Heitsch, Laura, Holmegaard, Lukas, Jood, Katarina, Jimenez-Conde, Jordi, Kittner, Steven J., Lemmens, Robin, Levi, Christopher R., McDonough, Caitrin W., Meschia, James F., Phuah, Chia-Ling, Rolfs, Arndt, Ropele, Stefan, Rosand, Jonathan, Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Söderholm, Martin, Sousa, Alessandro, Stanne, Tara M., Strbian, Daniel, Tatlisumak, Turgut, Thijs, Vincent, Vagal, Achala, Wasselius, Johan, Woo, Daniel, Zand, Ramin, McArdle, Patrick F., Worrall, Bradford B., Jern, Christina, Lindgren, Arne G., Maguire, Jane, Fox, Michael D., Bzdok, Danilo, Wu, Ona, Rost, Natalia S., Universitat Autònoma de Barcelona, Neurologian yksikkö, and HUS Neurocenter more...
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sex differences ,Science & Technology ,AREA ,General Engineering ,3112 Neurosciences ,Clinical Neurology ,Neurosciences ,lesion patterns ,3124 Neurology and psychiatry ,functional outcomes ,Bayesian hierarchical modelling ,Neurosciences & Neurology ,HUMAN CEREBRAL-CORTEX ,Life Sciences & Biomedicine ,acute ischaemic stroke - Abstract
Relying on neuroimaging and clinical data of 822 acute stroke patients, Bonkhoff et al. report substantially more detrimental effects of lesions in left-hemispheric posterior circulation regions on functional outcomes in women compared to men. These findings may motivate a sex-specific clinical stroke management to improve outcomes in the longer term. Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. We relied on 822 acute ischaemic patients [age: 64.7 (15.0) years, 39% women] originating from the multi-centre MRI-GENIE study to model unfavourable outcomes (modified Rankin Scale >2) based on acute neuroimaging data in a Bayesian hierarchical framework. Lesions encompassing bilateral subcortical nuclei and left-lateralized regions in proximity to the insula explained outcomes across men and women (area under the curve = 0.81). A pattern of left-hemispheric posterior circulation brain regions, combining left hippocampus, precuneus, fusiform and lingual gyrus, occipital pole and latero-occipital cortex, showed a substantially higher relevance in explaining functional outcomes in women compared to men [mean difference of Bayesian posterior distributions (men - women) = -0.295 (90% highest posterior density interval = -0.556 to -0.068)]. Once validated in prospective studies, our findings may motivate a sex-specific approach to clinical stroke management and hold the promise of enhancing outcomes on a population level. more...
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- 2022
28. L’âge cérébral radiomique prédit le pronostic fonctionnel après un avc ischémique.
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Bretzner, Martin, primary, Bonkhoff, Anna, additional, Schirmer, Markus, additional, Hong, Sungmin, additional, Dalca, Adrian, additional, Donahue, Kathleen, additional, Giese, Anne-Katrin, additional, Etherton, Mark, additional, Rist, Pamela, additional, Nardin, Marco, additional, Regenhardt, Robert, additional, Leclerc, Xavier, additional, Lopes, Renaud, additional, Gautherot, Morgan, additional, Wang, Clinton, additional, Benavente, Oscar, additional, Cole, John, additional, Donatti, Amanda, additional, Griessenauer, Christoph, additional, Heitsch, Laura, additional, Holmegaard, Lukas, additional, Jood, Katarina, additional, Conde, Jordi Jimenez, additional, Kittner, Steven, additional, Lemmens, Robin, additional, Levi, Christopher, additional, McArdle, Patrick, additional, McDonough, Caitrin, additional, Meshia, James, additional, Phuah, Chia-Ling, additional, Rolfs, Arndt, additional, Ropele, Stefan, additional, Rosand, Jonathan, additional, Roquer, Jaume, additional, Rundek, Tatjana, additional, Sacco, Ralph, additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Sousa, Alessandro, additional, Stanne, Tara, additional, Strbian, Daniel, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Vagala, Achala, additional, Wasselius, Johan, additional, Woo, Daniel, additional, Wu, Ona, additional, Zand, Ramin, additional, Worrall, Bradford, additional, Maguire, Jane, additional, Lindgren, Arne, additional, Jern, Christina, additional, Golland, Polina, additional, Kuchcinski, Gregory, additional, and Rost, Natalia, additional more...
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- 2022
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29. Deep profiling of multiple ischemic lesions in a large, multi-center cohort. Frequency, spatial distribution, and associations to clinical characteristics
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Bonkhoff, Anna K., Jiménez Conde, Jordi, Roquer, Jaume, and Wasselius, Johan
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Bayesian hierarchical regression ,Magnetic resonance imaging ,Lesion volume ,Acute ischemic stroke ,Multiple acute ischemic lesions ,Quantitative imaging - Abstract
Background purpose: a substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort. Materials and methods: analyses relied upon imaging and clinical data from the international MRI-GENIE study. Imaging data comprised both Fluid-attenuated inversion recovery (FLAIR) for white matter hyperintensity (WMH) burden estimation and diffusion-weighted imaging (DWI) sequences for the assessment of acute stroke lesions. The initial step featured the systematic evaluation of occurrences of MAL within one and several vascular supply territories. Associations between MAL and important imaging and clinical characteristics were subsequently determined. The interaction effect between single and multiple lesion status and lesion volume was estimated by means of Bayesian hierarchical regression modeling for both stroke severity and functional outcome. Results: we analyzed 2,466 patients (age = 63.4 ± 14.8, 39% women), 49.7% of which presented with a single lesion. Another 37.4% experienced MAL in a single vascular territory, while 12.9% featured lesions in multiple vascular territories. Within most territories, MAL occurred as frequently as single lesions (ratio ∼1:1). Only the brainstem region comprised fewer patients with MAL (ratio 1:4). Patients with MAL presented with a significantly higher lesion volume and acute NIHSS (7.7 vs. 1.7 ml and 4 vs. 3, p FDR < 0.001). In contrast, patients with a single lesion were characterized by a significantly higher WMH burden (6.1 vs. 5.3 ml, p FDR = 0.048). Functional outcome did not differ significantly between patients with single versus multiple lesions. Bayesian analyses suggested that the association between lesion volume and stroke severity between single and multiple lesions was the same in case of anterior circulation stroke. In case of posterior circulation stroke, lesion volume was linked to a higher NIHSS only among those with MAL. Conclusion: multiple lesions, especially those within one vascular territory, occurred more frequently than previously reported. Overall, multiple lesions were distinctly linked to a higher acute stroke severity, a higher total DWI lesion volume and a lower WMH lesion volume. In posterior circulation stroke, lesion volume was linked to a higher stroke severity in multiple lesions only. more...
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- 2022
30. Cystatins – Extra- and intracellular cysteine protease inhibitors: High-level secretion and uptake of cystatin C in human neuroblastoma cells
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Wallin, Hanna, Bjarnadottir, Maria, Vogel, Lotte K., Wassélius, Johan, Ekström, Ulf, and Abrahamson, Magnus
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- 2010
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31. Detection of Unilateral Arm Paresis after Stroke by Wearable Accelerometers and Machine Learning
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Wasselius, Johan, primary, Lyckegård Finn, Eric, additional, Persson, Emma, additional, Ericson, Petter, additional, Brogårdh, Christina, additional, Lindgren, Arne G., additional, Ullberg, Teresa, additional, and Åström, Kalle, additional more...
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- 2021
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32. Lesions in putative language and attention regions are linked to more severe strokes in patients with higher white matter hyperintensity burden
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Bonkhoff, Anna K, primary, Hong, Sungmin, additional, Bretzner, Martin, additional, Schirmer, Markus D, additional, Regenhardt, Robert W, additional, Arsava, Murat, additional, Donahue, Kathleen, additional, Nardin, Marco, additional, Dalca, Adrian, additional, Giese, Anne-Katrin, additional, Etherton, Mark, additional, Hancock, Brandon, additional, Mocking, Steven, additional, McIntosh, Elissa, additional, Attia, John, additional, Benavente, Oscar, additional, Cole, John W, additional, Donatti, Amanda, additional, Griessenauer, Christoph, additional, Heitsch, Laura, additional, Holmegaard, Lukas, additional, Jood, Katarina, additional, Jimenez-Conde, Jordi, additional, Kittner, Steven, additional, Lemmens, Robin, additional, Levi, Christopher, additional, McDonough, Caitrin, additional, Meschia, James, additional, Phuah, Chia-Ling, additional, Rolfs, Arndt, additional, Ropele, Stefan, additional, Rosand, Jonathan, additional, Roquer, Jaume, additional, Rundek, Tatjana, additional, Sacco, Ralph, additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Soederholm, Martin, additional, Sousa, Alessandro, additional, Stanne, Tara, additional, Strbian, Daniel, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Vagal, Achala, additional, Wasselius, Johan, additional, Woo, Daniel, additional, Zand, Ramin, additional, McArdle, Patrick, additional, Worrall, Bradford, additional, Jern, Christina, additional, Lindgren, Arne, additional, Maguire, Jane, additional, Golland, Polina, additional, Bzdok, Danilo, additional, Wu, Ona, additional, and Rost, Natalia S, additional more...
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- 2021
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33. Radiomics Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke
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Bretzner, Martin, primary, Bonkhoff, Anna, additional, Schirmer, Markus, additional, Hong, Sungmin, additional, Dalca, Adrian, additional, Donahue, Kathleen, additional, Giese, Anne-Katrin, additional, Etherton, Mark, additional, Rist, Pamela, additional, Nardin, Marco, additional, Regenhardt, Robert, additional, Leclerc, Xavier, additional, Lopes, Renaud, additional, Gautherot, Morgan, additional, Wang, Clinton, additional, Benavente, Oscar, additional, Cole, John, additional, Donatti, Amanda, additional, Griessenauer, Christoph, additional, Heitsch, Laura, additional, Holmegaard, Lukas, additional, Jood, Katharina, additional, Jiménez-Conde, Jordi, additional, Kittner, Steven, additional, Lemmens, Robin, additional, Levi, Christopher, additional, McArdle, Patrick, additional, McDonough, Caitrin, additional, Meschia, James, additional, Phuah, Chia-Ling, additional, Rolfs, Arndt, additional, Ropele, Stefan, additional, Rosand, Jonathan, additional, Roquer, Jaume, additional, Rundek, Tatjana, additional, Sacco, Ralph, additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Sousa, Alessandro Viana Oliveira e, additional, Stanne, Tara, additional, Strbian, Daniel, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Vagal, Achala, additional, Wasselius, Johan, additional, Woo, Daniel, additional, Wu, Ona, additional, Zand, Ramin, additional, Worrall, Bradford B., additional, Maguire, Jane, additional, Lindgren, Arne, additional, Jern, Christina, additional, Golland, Polina, additional, Kuchcinski, Grégory, additional, and Rost, Natalia, additional more...
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- 2021
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34. Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke
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Bretzner, Martin, Bonkhoff, Anna K., Schirmer, Markus D., Hong, Sungmin, Dalca, Adrian, Donahue, Kathleen, Giese, Anne-Katrin, Etherton, Mark R., Rist, Pamela M., Nardin, Marco, Regenhardt, Robert W., Leclerc, Xavier, Lopes, Renaud, Gautherot, Morgan, Wang, Clinton, Benavente, Oscar R., Cole, John W., Donatti, Amanda, Griessenauer, Christoph, Heitsch, Laura, Holmegaard, Lukas, Jood, Katarina, Jimenez-Conde, Jordi, Kittner, Steven J., Lemmens, Robin, Levi, Christopher R., McArdle, Patrick F., McDonough, Caitrin W., Meschia, James F., Phuah, Chia-Ling, Rolfs, Arndt, Ropele, Stefan, Rosand, Jonathan, Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Sousa, Alessandro, Stanne, Tara M., Strbian, Daniel, Tatlisumak, Turgut, Thijs, Vincent, Vagal, Achala, Wasselius, Johan, Woo, Daniel, Wu, Ona, Zand, Ramin, Worrall, Bradford B., Maguire, Jane, Lindgren, Arne G., Jern, Christina, Golland, Polina, Kuchcinski, Grégory, and Rost, Natalia S. more...
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- 2023
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35. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
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Bakker, Mark K., van der Spek, Rick A.A., van Rheenen, Wouter, Morel, Sandrine, Bourcier, Romain, Hostettler, Isabel C., Alg, Varinder S., van Eijk, Kristel R., Koido, Masaru, Akiyama, Masato, Terao, Chikashi, Matsuda, Koichi, Walters, Robin G., Lin, Kuang, Li, Liming, Millwood, Iona Y., Chen, Zhengming, Rouleau, Guy A., Zhou, Sirui, Rannikmäe, Kristiina, Sudlow, Cathie L.M., Houlden, Henry, van den Berg, Leonard H., Dina, Christian, Naggara, Olivier, Gentric, Jean-Christophe, Shotar, Eimad, Eugène, François, Desal, Hubert, Winsvold, Bendik S., Børte, Sigrid, Johnsen, Marianne Bakke, Brumpton, Ben M., Sandvei, Marie Søfteland, Willer, Cristen J., Hveem, Kristian, Zwart, John-Anker, Verschuren, W. M. Monique, Friedrich, Christoph M., Hirsch, Sven, Schilling, Sabine, Dauvillier, Jérôme, Martin, Olivier, Martinsen, Amy E, Aamodt, Anne Hege, Skogholt, Anne Heidi, Sandset, Else Charlotte, Kristoffersen, Espen S, Ellekjaer, Hanne, Heuch, Ingrid, Nielsen, Jonas Bille, Hagen, Knut, Fritsche, Lars, Thomas, Laurent F., Pedersen, Linda, Gabrielsen, Maiken E, Vigeland, Maria Dehli, Holmen, Oddgeir, Zhou, Wei, Chen, Junshi, Chen (PI), Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li (PI), Liming, Liu, Depei, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Bennett, Derrick, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gan, Wei, Gilbert, Simon, Hacker, Alex, Hill, Michael, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Lancaster, Garry, Lewington, Sarah, McDonnell, John, Millwood, Iona, Nie, Qunhua, Ryder, Paul, Sansome, Sam, Schmidt-Valle, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zou, Mingyuan, Yan, Shichun, Zhou, Xue, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Chen, Jinyan, Fu, Yan, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Hua, Yujie, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin Sisi Wang, Yulu, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhou, Ding Zhang, Zhou, Gang, Feng, Shixian, Chang, Ling, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Gong, Weiwei, Wang, Meng, Xie, Kaixu, Chen, Lingli, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Zhang, Libo, Nagai, Akiko, Muto, Kaori, Hirata, Makoto, Morisaki, Takayuki, Yamashita, Yasushi, Kamatani, Yoichiro, Kambara, Yoko, Murakami, Yoshinori, Masumoto, Akihide, Nagayama, Satoshi, Miki, Yoshio, Yoshimori, Kozo, Fujioka, Tomoaki, Takata, Ryo, Yamaji, Ken, Takahashi, Kazuhisa, Asai, Satoshi, Takahashi, Yasuo, Minami, Shiro, Yamaguchi, Hiroki, Koretsune, Yukihiro, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Suzuki, Takao, Sinozaki, Nobuaki, Murayama, Shigeo, Furukawa, Yoichi, Yamanashi, Yuji, Papagiannaki, Chrisanthi, Piotin, Michel, Trystram, Denis, Edjlali-Goujon, Myriam, Boulouis, Grégoire, Rodriguez, Christine, Hassen, Waghi Ben, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Levrier, Olivier, Aguettaz, Pierre, Combaz, Xavier, Pasco, Anne, l’Allinec, Vincent, Bintner, Marc, Molho, Marc, Pascale, Gauthier, Chivot, Cyril, Costalat, Vincent, Darganzil, Cyril, Bonafé, Alain, Januel, Anne Christine, Michelozzi, Caterina, Cognard, Christophe, Bonneville, Fabrice, Tall, Philippe, Darcourt, Jean, Biondi, Alessandra, Iosif, Cristina, Ferre, Jean Christophe, Gauvrit, Jean Yves, Eugene, François, Raoult, Hélène, Gentric, Jean Christophe, Ognard, Julien, Anxionnat, René, Gory, Benjamin, Bracard, Serge, Derelle, Anne Laure, Tonnelet, Romain, Spelle, Laurent, Ikka, Léon, Ozanne, Augustin, Gallas, Sophie, Caroff, Jildaz, Achour, Nidal Ben, Moret, Jacques, Chabert, Emmanuel, Berge, Jérôme, Marnat, Gaultier, Barreau, Xavier, Gariel, Florent, Clarencon, Frédéric, Aggour, Mohammed, Ricolfi, Frédéric, Chavent, Adrien, Thouant, Pierre, Lebidinsky, Pablo, Lemogne, Brivael, Herbreteau, Denis, Bibi, Richard, Janot, Kevin, Pierot, Laurent, Soize, Sébastien, Labeyrie, Marc Antoine, Vandendries, Christophe, Kazemi, Appoline, Leclerc, Xavier, Pruvo, Jean Pierre, Bricout, Nicolas, Velasco, Stéphane, Boucebci, Samy, Lemmens, Robin, Pandolfo, Massimo, Bodenant, Marie, Louillet, Fabien, Mas, Jean-Louis, Deltour, Sandrine, Leder, Sara, Léger, Anne, Canaple, Sandrine, Godefroy, Olivier, Giroud, Maurice, Jacquin, Agnès, Moulin, Thierry, Vuillier, Fabrice, Tzourio, Christophe, Santos, Michael Dos, Malik, Rainer, Hausser, Ingrid, Thomas-Feles, Constanze, Weber, Ralf, Grond-Ginsbach, Caspar, Hacke, Werner, Giossi, Alessia, Volonghi, Irene, Costa, Paolo, del Zotto, Elisabetta, Morotti, Andrea, Poli, Loris, Muiesan, Maria Lorenza, Salvetti, Massimo, Rosei, Enrico Agabiti, Lanfranconi, Silvia, Baron, Pierluigi, Ferrarese, Carlo, Susani, Emanuela, Giacalone, Giacomo, Paolucci, Stefano, Palmirotta, Raffaele, Guadagni, Fiorella, Paciaroni, Maurizio, Ballabio, Elena, Parati, Eugenio A., Fluri, Felix, Hatz, Florian, Gisler, Dominique, Amort, Margareth, Bevan, Steve, James, Tom, Olsson, Sandra, Holmegaard, Lukas, Altintas, Ayse, Martin, Juan José, Kittner, Steven, Mitchell, Braxton, Stine, Colin, O’Connell, Jeff, Dueker, Nicole, Koudstaal, Peter J., de Lau, Lonneke M.L., Hofman, Albert, Verhaaren, Benjamin F, Uitterlinden, Andre G, Montaner, Joan, Mendioroz, Maite, Yadav, Sunaina, Khan, Muhammad Saleem, Wilder, Michael, van Dijk, Ewoud, Maaijwee, Noortje, Rutten-Jacobs, Loes, Kramer, Jamie, Malik, Shaneela, Brott, Thomas G, Brown, Robert D, Singleton, Andrew, Hardy, John, Rich, Stephen S, Tanislav, Christian, Jungehülsing, Jan, Werring, David, Alg, Varinder, Hostettler, Isabel, Bonner, Stephen, Walsh, Daniel, Bulters, Diederik, Kitchen, Neil, Brown, Martin, Grieve, Joan, Roberts, Gareth, Jones, Timothy, Critchley, Giles, Sharma, Pankaj, Nelson, Richard, Whitfield, Peter, Ross, Stuart, Patel, Hiren, Eldridge, Paul, Saastamoinen, Kari, Patel, Umang, Lawrance, Enas, Vandabona, Subha, Mendelow, David, Teal, Rachel, Warner, Orlando, Kirkpatrick, Peter, Seshadri, Sudha, Kilarski, Laura, Hyacinth, Hyacinth I, Oliveira, Jamary, Marini, Sandro, Nyquist, Paul, Lewis, Cathryn, Norrving, Bo, Smith, Gustav, Rosand, Jonathan, Biffi, Alessandro, Kourkoulis, Christina, Anderson, Chris, Giese, Anne-Katrin, Bang, Oh Young, Chung, Jong-Won, Kim, Gyeong-Moon, Zhuang, Qishuai, Sheu, Wayne, Smalley, June, Howson, Joanna, Granata, Alessandra, Markus, Hugh, Wardlaw, Joanna, Cole, John, Thalamuthu, Anbupalam, Hopewell, Jemma, Worrall, Bradford, Bis, Josh, Tirschwell, David, Reiner, Alex, Dhar, Raj, Lee, Jin-Moo, Mortenson, Janne, Wassertheil-Smoller, Sylvia, Prasad, Kameshwar, Fisher, Mark, Traenka, Christopher, Wang, Xingwu, Wang, Yongjun, Rouanet, Francois, Sibon, Igor, Sarnowski, Chloé, Maillard, Pauline, Aparicio, Hugo Javier, Dupuis, Josee, Yang, Qiong, Luvizutto, Gustavo, Chasman, Daniel, Rexrode, Kathryn, Harriot, Andrea, Phuah, Chia-Ling, Santo, Gustavo, Gerard, Jen, Liu, Guiyou, Aaron, Sanjith, Christudass, Christhunesa S., Salomi, BSB, Sanghera, Dharambir, Boehme, Amelia, Elkind, Mitchell, Gretarsdottir, Solveig, Lange, Leslie, Rost, Natalia, James, Michael, Stewart, Jill, Goldstein, Larry, Waddy, Salina, Vojinovic, Dina, Ikram, Arfan, Thijs, Vincent, Parati, Eugenio, Boncoraglio, Giorgio, Kooperberg, Charles, Abboud, Sherrine, Zand, Ramin, Bijlenga, Philippe, Selim, Magdy, Happola, Olli, Strbian, Daniel, Tomppo, Liisa, Pathak, Abhishek, Pfeiffer, Dorothea, Aires, de Buenos, de Carvalho, Joao Jose Freitas, Ribeiro, Priscila, Torres, Nuria, Barboza, Miguel, Plomaritoglou, Androniki, Bjorkegren, Johan, Chan, Yu-Feng Yvonne, Gudnason, Villi, Jimenez-Conde, Jordi, Soriano, Carolina, Roquer, Jaume, Bentley, Paul, Tournier-Lasserve, Elisabeth, Dufouil, Carole, Debette, Stephanie, Mishra, Aniket, Wee, Lawrence, Siddiqi, Saima, Wu, Jer-Yuarn, Ko, Tai-Ming, Bione, Silvia, Jood, Katarina, Tatlisumak, Turgut, Arauz, Antonio, Korostynski, Michal, Launer, Lenore, Yue, Suo, bersano, anna, Juchniewicz, Karol Józef, Mateusz, Adamski, Pera, Joanna, Wnuk, Marcin, Levi, Christopher, Gusdon, Aaron, Kostulas, Konstantinos, Maxwell, Jessye, Duering, Marco, Jagiella, Jeremiasz, Hata, Jun, Ninomiya, Toshiharu, Nguyen, Vinh, Thorarinsson, Bjorn Logi, Lee, Tsong-Hai, Rakitko, Alexandr, Dichgans, Martin, Lindgren, Arne, Wasselius, Johan, Drake, Mattias, Stenman, Martin, Ilinca, Andreea, Staals, Julie, Sadr-Nabavi, Ariane, Crawford, Katherine, Lena, Umme, Mateen, Farrah, Ay, Hakan, Wu, Ona, Schirmer, Markus, Romero, Javier, Cramer, Steve, Golland, Polina, Mueller, Bertram, Brown, Robert, Meschia, James, Ross, Owen A., Pare, Guillaume, Chong, Mike, mansour, Ossama yassin, Karaszewski, Bartosz, Enzinger, Christian, Schmidt, Reinhold, Seiler, Stephan, Pichler, Alexander, Ovbiagele, Bruce, Yamada, Yoshiji, Rundek, Tatjana, Blanton, Susan, P, John, Chern, Joseph, O'Donnell, Chris, Corriveau, Roderick, Bhattacharya, Pallab, Gwinn, Katrina, CHANDRA, BHARATENDU, Chen, Christopher, Kalaria, Raj, Koenig, Jim, Singh, Om Prakash, Olugbodi, Akintomi, Giralt, Eva, Saleheen, Danish, de Leeuw, Frank-Erik, Klijn, Karin, Olesen, Jes, Kubo, Michiaki, Spence, David, Pedersen, Annie, Olsson, Maja, Martín, Juan José, Braga, Gabriel, Xu, Huichun, Assimes, Tim, Raskurazhev, Anton, Lee, Wei Ling, Burri, Philippe, Frid, Petrea, GmbH, Heilbronn, Deng, Zhen, Habibi-koolaee, Mahdi, Vijayan, Murali, Leung, Thomas, Wong, Lawrence, Mok, Vincent, Choy, Richard, Jern, Christina, Lebedeva, Elena, Farrall, Martin, Jiayuan, Xu, Loo, Keat Wei, Rinkel, Gabriel, Magnus, Rudolf, Goncalves, Anderson, Franca, Paulo, Cendes, Iscia, Carrera, Caty, Fernandez-Cadenas, Israel, Kim, Helen, Rolfs, Arndt, Owolabi, Mayowa, Bakker, Mark, Ruigrok, Ynte, Hauer, Allard, Pulit, Sara L., Algra, Ale, van der Laan, Sander W., Macleod, Mary, Howard, George, Tiwari, Hemant, Irvin, Ryan, Albright, Karen C., Perry, Rodney, Kidwell, Chelsea, Pavlovic, Aleksandra, Sargurupremraj, Murali, Schilling, Sabrina, Pezzini, Alessandro, Abd-Allah, Foad, DeCarli, Charles, Liebeskind, David, Traylor, Matthew, Tan, Rhea, Danesh, John, Larsson, Susanna C., Rutten, Loes, Donatti, Amanda, Avelar, Wagner, Broderick, Joseph, Woo, Daniel, Kissela, Brett, Ibenez, Laura Garcia, Salman, Rustam, Sudlow, Cathie, McDonough, Caitrin Wheeler, Silliman, Scott, Magvanjav, Oyunbileg, van Agtmael, Tom, Walters, Matthew, Lorentzen, Erik, Stanne, Tara, Olsson, Martina, Nakagawa, Kazuma, Akinyemi, Rufus, Cotlatciuc, Ioana, O'Connell, Jeff, Sparks, Mary, Sorkin, John, Dave, Tushar, Naylor, Jill, Brown, Devin, Du, Rose, Kulik, Tobias B., Attia, John, Faber, James E, Rothwell, Peter, Márquez, Elsa Valdés, Mancuso, Michelangelo, Souza, Doralina Brum, de Silva, Ranil, Vibo, Riina, Korv, Janika, Maguire, Jane, Fornage, Myriam, Illoh, Kachikwu, Milewicz, Dianna, Majersik, Jennifer, DeHavenon, Adam, Kalani, Yashar, Alexander, Matthew, Cushman, Mary, Sale, Michele, Owens, Debra, Keene, Keith, Rich, Stephe, Psaty, Bruce, Longstreth, Will, Atadzhanov, Masharip, Wolfe, Stacey Quintero, Langefeld, Carl, Bushnell, Cheryl, Cruchaga, Carlos, Konrad, Jan, Liu, Junfeng, Sheth, Kevin, Falcone, Guido, Donahue J, Kathleen, Jones, Gregory T., Bown, Matthew J., Ko, Nerissa U., Coleman, Jonathan R.I., Breen, Gerome, Zaroff, Jonathan G., Klijn, Catharina J.M., Sargurupremraj, Muralidharan, Amouyel, Philippe, Debette, Stéphanie, Rinkel, Gabriel J.E., Worrall, Bradford B., Slowik, Agnieszka, Gaál-Paavola, Emilia I., Niemelä, Mika, Jääskeläinen, Juha E., von Und Zu Fraunberg, Mikael, Lindgren, Antti, Broderick, Joseph P., Werring, David J., Redon, Richard, Veldink, Jan H., Ruigrok, Ynte M., Stroke, HUNT All-In, Group, China Kadoorie Biobank Collaborative, Consortium, BioBank Japan Project, Group, ICAN Study, Group, CADISP, investigators, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study, (ISGC), International Stroke Genetics Consortium, Morel, Sandrine, and Bijlenga, Philippe Alexandre Pierre more...
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genetics [Blood Pressure] ,Medizin ,Genome-wide association study ,Blood Pressure ,Disease ,ddc:616.07 ,Bioinformatics ,616: Innere Medizin und Krankheiten ,0302 clinical medicine ,Risk Factors ,physiopathology [Hypertension] ,genetics [Genetic Predisposition to Disease] ,Genetic risk factor ,Stroke ,0303 health sciences ,Smoking ,genetics [Smoking] ,genetics [Intracranial Aneurysm] ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Cerebrovascular disorder ,3. Good health ,genetics [European Continental Ancestry Group] ,Hypertension ,genetics [Polymorphism, Single Nucleotide] ,Subarachnoid hemorrhage ,pathology [Intracranial Aneurysm] ,genetics [White People] ,Biology ,Genetic correlation ,pathology [Endothelial Cells] ,Polymorphism, Single Nucleotide ,Article ,White People ,03 medical and health sciences ,Aneurysm ,Asian People ,ddc:570 ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,cardiovascular diseases ,030304 developmental biology ,genetics [Subarachnoid Hemorrhage] ,genetics [Asian Continental Ancestry Group] ,572: Biochemie ,genetics [Asian People] ,pathology [Subarachnoid Hemorrhage] ,adverse effects [Smoking] ,Endothelial Cells ,Subarachnoid Hemorrhage ,medicine.disease ,Intracranial aneurysm ,Genetic architecture ,ddc:616.8 ,Case-Control Studies ,genetics [Hypertension] ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
An author correction to this article published in December 2020 is available at https://doi.org/10.1038/s41588-020-00760-4. Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits. more...
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- 2021
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36. MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes
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Bretzner, Martin, primary, Bonkhoff, Anna K., additional, Schirmer, Markus D., additional, Hong, Sungmin, additional, Dalca, Adrian V., additional, Donahue, Kathleen L., additional, Giese, Anne-Katrin, additional, Etherton, Mark R., additional, Rist, Pamela M., additional, Nardin, Marco, additional, Marinescu, Razvan, additional, Wang, Clinton, additional, Regenhardt, Robert W., additional, Leclerc, Xavier, additional, Lopes, Renaud, additional, Benavente, Oscar R., additional, Cole, John W., additional, Donatti, Amanda, additional, Griessenauer, Christoph J., additional, Heitsch, Laura, additional, Holmegaard, Lukas, additional, Jood, Katarina, additional, Jimenez-Conde, Jordi, additional, Kittner, Steven J., additional, Lemmens, Robin, additional, Levi, Christopher R., additional, McArdle, Patrick F., additional, McDonough, Caitrin W., additional, Meschia, James F., additional, Phuah, Chia-Ling, additional, Rolfs, Arndt, additional, Ropele, Stefan, additional, Rosand, Jonathan, additional, Roquer, Jaume, additional, Rundek, Tatjana, additional, Sacco, Ralph L., additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Sousa, Alessandro, additional, Stanne, Tara M., additional, Strbian, Daniel, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Vagal, Achala, additional, Wasselius, Johan, additional, Woo, Daniel, additional, Wu, Ona, additional, Zand, Ramin, additional, Worrall, Bradford B., additional, Maguire, Jane M., additional, Lindgren, Arne, additional, Jern, Christina, additional, Golland, Polina, additional, Kuchcinski, Grégory, additional, and Rost, Natalia S., additional more...
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- 2021
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37. Time dependence in diffusion MRI predicts tissue outcome in ischemic stroke patients
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Lampinen, Björn, primary, Lätt, Jimmy, additional, Wasselius, Johan, additional, Westen, Danielle, additional, and Nilsson, Markus, additional
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- 2021
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38. Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes
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Bretzner, Martin, primary, Bonkhoff, Anna K., additional, Schirmer, Markus D., additional, Hong, Sungmin, additional, Dalca, Adrian V., additional, Donahue, Kathleen L., additional, Giese, Anne-Katrin, additional, Etherton, Mark R., additional, Nardin, Marco, additional, Marinescu, Razvan, additional, Wang, Clinton, additional, Regenhardt, Robert W., additional, Leclerc, Xavier, additional, Lopes, Renaud, additional, Benavente, Oscar R., additional, Cole, John W., additional, Donatti, Amanda, additional, Griessenauer, Christoph J., additional, Heitsch, Laura, additional, Holmegaard, Lukas, additional, Jood, Katarina, additional, Jimenez-Conde, Jordi, additional, Kittner, Steven J., additional, Lemmens, Robin, additional, Levi, Christopher R., additional, McArdle, Patrick D., additional, McDonough, Caitrin W., additional, Meschia, James F., additional, Phuah, Chia-Ling, additional, Rolfs, Arndt, additional, Ropele, Stefan, additional, Rosand, Jonathan, additional, Roquer, Jaume, additional, Rundek, Tatjana, additional, Sacco, Ralph L., additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Sousa, Alessandro, additional, Stanne, Tara M., additional, Strebian, Daniel, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Vagal, Achala, additional, Wasselius, Johan, additional, Woo, Daniel, additional, Wu, Ona, additional, Zand, Ramin, additional, Worrall, Bradford B., additional, Maguire, Jane, additional, Lindgren, Arne, additional, Jern, Christina, additional, Golland, Polina, additional, Kuchcinski, Grégory, additional, Rost, Natalia S., additional, Investigators, MRI-GENIE and GISCOME, additional, and Consortium, International Stroke Genetics, additional more...
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- 2021
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39. Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke
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Schirmer, Markus D., primary, Donahue, Kathleen L., additional, Nardin, Marco J., additional, Dalca, Adrian V., additional, Giese, Anne-Katrin, additional, Etherton, Mark R., additional, Mocking, Steven J.T., additional, McIntosh, Elissa C., additional, Cole, John W., additional, Holmegaard, Lukas, additional, Jood, Katarina, additional, Jimenez-Conde, Jordi, additional, Kittner, Steven J., additional, Lemmens, Robin, additional, Meschia, James F., additional, Rosand, Jonathan, additional, Roquer, Jaume, additional, Rundek, Tatjana, additional, Sacco, Ralph L., additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Stanne, Tara M., additional, Vagal, Achala, additional, Wasselius, Johan, additional, Woo, Daniel, additional, Bevan, Stephen, additional, Heitsch, Laura, additional, Phuah, Chia-Ling, additional, Strbian, Daniel, additional, Tatlisumak, Turgut, additional, Levi, Christopher R., additional, Attia, John, additional, McArdle, Patrick F., additional, Worrall, Bradford B., additional, Wu, Ona, additional, Jern, Christina, additional, Lindgren, Arne, additional, Maguire, Jane, additional, Thijs, Vincent, additional, and Rost, Natalia S., additional more...
- Published
- 2020
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40. Abstract WP73: Automatic Classification of Clinical MRI Stroke Datasets With a Recurrent Convolutional Neural Network
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Liu, Yichuan, primary, Hancock, Brandon L, additional, Hoang, Tri, additional, Etherton, Mark R, additional, Mocking, Steven J, additional, McIntosh, Elissa C, additional, Irie, Robert E, additional, Bouts, Mark J, additional, Broderick, Joseph P, additional, Cole, John W, additional, Donahue, Kathleen L, additional, Giese, Anne-Katrin, additional, Giralt-Steinhauer, Eva, additional, Jimenez-Conde, Jordi, additional, Jern, Christina, additional, Kittner, Steven J, additional, Kleindorfer, Dawn, additional, Lemmens, Robin, additional, McArdle, Patrick F, additional, Meschia, James F, additional, Lindgren, Arne G, additional, Rosand, Jonathan, additional, Rundek, Tatjana, additional, Sacco, Ralph L, additional, Schirmer, Markus D, additional, Schmidt, Reinhold, additional, Sharma, Pankaj, additional, Slowik, Agnieszka, additional, Thijs, Vincent, additional, Wasselius, Johan, additional, Worrall, Bradford B, additional, Rost, Natalia S, additional, and Wu, Ona, additional more...
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- 2020
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41. Fetal posterior cerebral artery configurations in an ischemic stroke versus an unselected hospital population.
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Frid, Petrea, Wasselius, Johan, Drake, Mattias, Wu, Ona, Petersson, Jesper, Rost, Natalia S., and Lindgren, Arne
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- *
POSTERIOR cerebral artery , *ISCHEMIC stroke , *STROKE patients - Abstract
Background: Few MRA‐based studies have systematically evaluated the prevalence and laterality of a fetal configuration of the posterior cerebral artery (FTP) in ischemic stroke populations versus other populations. This common variant is important in the setting of acute stroke and secondary prevention decisions. Objective: To determine the prevalence and laterality of FTP configurations in MRI‐DWI verified acute ischemic stroke patients investigated with MRA, and compare the findings with an unselected hospital population investigated with computed tomography angiography (CTA). We also evaluated the association of FTP with posterior cerebral artery (PCA) territory infarctions. Methods: We reviewed the MRAs of 1407 ischemic stroke patients with acute lesions on MRI‐DWI sequences and 546 consecutive CTAs of patients investigated on any indication in a tertiary hospital. The MRA and CTA assessments were made by neuroradiologists blinded to original reports on stroke location and vessel anatomy. Results: The prevalence of any FTP was similar in ischemic stroke patients (31%) and unselected patients (32%). Unilateral FTP was significantly more frequent on the right than on the left side in both groups (15% right vs. 8% left). The presence of FTP ipsilateral to stroke side was not associated with involvement of the PCA territory versus no FTP on the stroke side. Conclusions: FTP is present in approximately 30% of ischemic stroke patients and unselected hospital populations and was detected significantly more frequently on the right versus left side in both groups. PCA territory infarction was not associated with the presence of ipsilateral FTP. [ABSTRACT FROM AUTHOR] more...
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- 2022
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42. Big data approaches to phenotyping acute ischemic stroke using automated lesion segmentation of multi-center MRI data
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Wu, Ona, Winzeck, Stefan, Giese, Anne-Katrin, Hancock, Brandon L., Etherton, Mark R., Bouts, Mark J. R. J., Donahue, Kathleen, Schirmer, Markus D., Irie, Robert E., Mocking, Steven J. T., McIntosh, Elissa C., Bezerra, Raquel, Kamnitsas, Konstantinos, Frid, Petrea, Wasselius, Johan, Cole, John W., Xu, Huichun, Holmegaard, Lukas, Jiménez-Conde, Jordi, Lemmens, Robin, Lorentzen, Eric, McArdle, Patrick F., Meschia, James F., Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Stanne, Tara M., Thijs, Vincent, Vagal, Achala, Woo, Daniel, Bevan, Stephen, Kittner, Steven J., Mitchell, Braxton D., Rosand, Jonathan, Worrall, Bradford B., Jern, Christina, Lindgren, Arne G., Maguire, Jane, and Rost, Natalia S. more...
- Subjects
Adult ,Aged, 80 and over ,Big Data ,Male ,Observer Variation ,Middle Aged ,Article ,Brain Ischemia ,Machine Learning ,Stroke ,Diffusion Magnetic Resonance Imaging ,Phenotype ,Socioeconomic Factors ,Risk Factors ,Image Processing, Computer-Assisted ,Humans ,Female ,Neural Networks, Computer ,Algorithms ,Aged ,Retrospective Studies - Abstract
BACKGROUND AND PURPOSE: We evaluated deep learning algorithms’ segmentation of acute ischemic lesions on heterogeneous multi-center clinical diffusion-weighted (DWI) datasets and explored the potential role of this tool for phenotyping acute ischemic stroke. METHODS: Ischemic stroke data sets from the MRI-GENetics Interface Exploration (MRI-GENIE) repository consisting of 12 international genetic research centers were retrospectively analyzed using an automated deep learning segmentation algorithm consisting of an ensemble of 3D convolutional neural networks (CNNs). Three ensembles were trained using data from: (1) 267 patients from an independent single-center cohort, (2) 267 patients from MRI-GENIE, and (3) mixture of (1) and (2). The algorithms’ performances were compared against manual outlines from a separate 383 patient subset from MRI-GENIE. Univariable and multivariable logistic regression with respect to demographics, stroke subtypes and vascular risk factors were performed to identify phenotypes associated with large acute DWI volumes and greater stroke severity in 2770 MRI-GENIE patients. Stroke topography was investigated. RESULTS: The ensemble consisting of a mixture of MRI-GENIE and single-center CNNs performed best. Subset analysis comparing automated and manual lesion volumes in 383 patients found excellent correlation (ρ=0.92, p more...
- Published
- 2019
43. Generell anestesi ökar chanserna till LYCKAD TROMBEKTOMI.
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Wasselius, Johan
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- 2024
44. DETECTION OF EARLY CEREBRAL CORTICAL ISCHEMIA USING MONOENERGETIC IMAGES COMPARED TO CONVENTIONAL POLYENERGETIC IMAGES
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Wasselius, Johan
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Background and PurposeEarly cortical ischemic changes may be difficult to detect on conventional computer tomography (CT), but virtual monoenergetic images (VMIs) may improve detection rates through increased soft tissue contrast. We compared the ability of VMIs to detect early cerebral ischemia in patients with acute ischemic stroke to conventional polyenergetic images (CIs).MethodsWe screened all patients at our department who underwent brain CT in a Philips dual-layer IQon Spectral CT examined for clinical suspicion of acute stroke, last seen well more...
- Published
- 2017
45. STROKE DETECTION BY WEARABLE ACCELEROMETERS u2013PROOF OF CONCEPT OF A STROKE ALARM
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Wasselius, Johan
- Abstract
Background and PurposeRecent advances in stroke treatment has provided effective tools to successfully treat ischemic stroke, but still the most common patient is the one not treated due to late arrival to hospital. Early detection may improve treatment outcome and facilitate expansion of reperfusion treatment to a larger portion of stroke patients. This prospective study was conducted to assess the capability to detect stroke within clinically relevant times by using bilateral bracelet accelerometers.Methods: Motion data were collected by wearable 3-axis bracelet accelerometer for 24 hours on 30 stroke patients with unilateral arm motor impairment and 30 healthy subjects. Accelerometer data were analysed using machine-learning algorithms. Results: The sensitivity and specificity for detection of stroke-affected arms are shown by the Receiver Operating Characteristic (ROC) curves by analysing periods between 3 seconds up to 100 minutes. The Area Under the Curve (AUC) increased from 0.7136 for 3s analysis, 0.9490 for 25 minutes, and 0.9881 for 100 minutes. Conclusions: The 3-axis bracelet accelerometer shows a high detection rate with a low false positives rate at time-samples less than 30 minutes, thereby providing a wearable easy-to-use stroke detection system. We suggest that such a stroke alarm may be reasonable and cost-effective to ensure early detection in the event of a stroke in high-risk patients with recent TIA, stroke or atrial fibrillation. more...
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- 2017
46. ESTIMATED POTENTIAL OUTCOME AUGMENTATION AND HEALTH ECONOMIC BENEFITS OF A WEARABLE STROKE ALARM
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Wasselius, Johan
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Background and PurposeAlthough recent advances have provided effective treatments for ischemic stroke, a majority of patients are not treated due arrival beyond the time window for reperfusion treatment. Based on a health-economic model, we estimated the potential improvement of outcomes and cost reduction attained by shortening the time to thrombectomy for stroke patients with Large Vessel Occlusions (LVO) using bilateral accelerometers worn in bracelets that can detect stroke within 30 minutes of onset. Methods: Outcome data for thrombectomy patients with anterior circulation LVO were obtained from a meta-analysis of several recent randomized trials (HERMES collaboration). Outcome data for untreated LVO patients (controls) were obtained from the DEFUSE3 trial. Health economic effects were based on costs estimation (including QALY-estimations) for each level of the MRS-scale by Mangla et al 2016. Results: The potential treatment outcome benefit for ischemic stroke patients with anterior circulation LVO is substantial if treatment could be done within 3h of onset instead of within 8h, which may be possible by detection within 30-60 minutes of onset. The average cost reduction would be 481.470 USD/patient for the pooled populations within the HERMES collaboration. However, the greatest effect would come from allowing patients that are otherwise not treated due to late arrival to hospital to be treated within 3h of onset. The average cost reduction in this group would be 1.162.000 USD/patient.Conclusions: Early stroke detection using a wearable stroke alarm that detects major stroke within 30 minutes would potentially augment thrombectomy outcome profoundly, with substantial positive health economic effects. more...
- Published
- 2017
47. Accuracy of uncalibrated 2D digital subtraction angiography measurements on a novel biplane system compared to computed tomography angiography
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Landström, Lovisa and Wasselius, Johan A
- Abstract
Background 2D digital subtraction angiography (DSA) images are the gold standard for neuroradiological vascular assessment and the basis of interventional procedures such as mechanical thrombectomy and cerebral aneurysm coiling. However, length measurements in projected DSA images are affected by the distance between the x-ray source, the object, and the detector. Precise coordination between all integrated parts of a novel biplane system makes it possible to accurately measure DSA distances without manual calibration. The aim of this study was to compare vascular diameter measurements in uncalibrated DSA images with computed tomography angiography (CTA).Methods Consecutive patients undergoing interventional neuroradiological procedures were retrospectively included. Vascular diameter measurements in the image isocenter and periphery were performed. These measurements were repeated in picture archiving and communication system (PACS) on DSA images and maximum intensity pixel (MIP) CTA images.Results Forty-two (42) consecutive patients with adequate DSA and CTA images were included in the final analysis. The correlation between vessel diameter measurements in the image isocenter (R2= 0.81/0.85, p < 0.0001/p < 0.0001 [Reader1/Reader2]), periphery (R2= 0.85/0.82, p < 0.0001/p < 0.0001 [Reader1/Reader2]), and all measurements combined (R2= 0.87/0.87, p < 0.0001/p < 0.0001 [Reader1/Reader2]) on DSA and CTA were strong and statistically significant. The interclass correlation coefficient for measurements performed by two independent reviewers was strong (ICC = 0.96, 95% CI 0.92–0.98).Conclusions The correlations between uncalibrated DSA measurements and CTA for vessel diameter were strong. In addition, there were strong correlations between these image types for repeated measurements in the image isocenter as well as image periphery for vessel diameter. Consequently, endovascular devices can be sized correctly without the need for pre-operative non-invasive imaging. more...
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- 2024
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48. Gadofosveset-enhanced magnetic resonance venography in patients with venous pathology of the lower limbs - Comparison of diagnostic image quality and inter-rater variability with gadobutrol venography and computed tomography venography.
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Åkesson, Michael, Lehti, Leena, Höglund, Peter, Åkeson, Per, Wasselius, Johan, Åkesson, Michael, Lehti, Leena, Höglund, Peter, Åkeson, Per, and Wasselius, Johan
- Abstract
This study was performed to compare the diagnostic quality of Gadofosveset-enhanced magnetic resonance venography with Gadobutrol-enhanced magnetic resonance venography and computed tomography venography for the deep veins of the lower extremities in patients with iliocaval venous pathology. more...
- Published
- 2015
49. Postoperative CT Evaluation After EVAR
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Törnqvist, Per, primary, Resch, Timothy, additional, Gottsäter, Anders, additional, Malina, Martin, additional, and Wasselius, Johan, additional
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- 2015
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50. Postoperative CT Evaluation After EVAR: A Comparison of Image Assessment.
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Törnqvist, Per, Resch, Timothy, Gottsäter, Anders, Malina, Martin, and Wasselius, Johan
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CARDIAC aneurysms ,ANGIOGRAPHY ,COMPUTED tomography - Abstract
Purpose: To compare the postoperative computed tomography angiography (CTA) assessment made by vascular surgeons and interventional radiologists after endovascular aneurysm repair (EVAR) at a tertiary vascular clinic to an outside core review facility.Methods: One hundred patients (mean age 78.7 years, range 88-55; 84 men) with consecutive, elective, routine CTA controls after EVAR were retrospectively studied. Consultant vascular surgeons or radiologists had evaluated all original scans and written the original report. All scans were then reevaluated by an independent core clinic. Findings were classified as vascular or extravascular and stratified as clinically significant or clinically nonsignificant by an independent external reviewer.Results: The number of vascular findings detected by the vascular clinic was 72 vs 69 by the core clinic. The vascular clinic reported more clinically significant findings (primarily stent compression or kinks) as well as endoleaks and their origin. The core clinic reported more pseudoaneurysms (24 vs 12). None of the patients with puncture complications needed reintervention. Interrater analysis of all findings between the 2 clinics showed good agreement when comparing endoleaks overall (without subclassification) and moderate agreement when assessing aneurysm growth. The core clinic reported extravascular findings in 58 patients; 37 of these were classified as clinically significant. The vascular clinic reported extravascular findings in 23 patients; 7 of these were clinically significant. The core clinic also reported 2 cases of suspected malignancies, which had not been reported by the vascular clinic.Conclusion: During routine CTA follow-up after EVAR, a significant number of vascular and nonvascular findings are detected. Whereas a highly dedicated vascular clinic identifies most vascular findings regardless of the specialty of the reader, some extravascular findings are missed. However, the frequency of clinically significant findings or findings that might warrant reintervention was low in this study. [ABSTRACT FROM AUTHOR] more...- Published
- 2016
- Full Text
- View/download PDF
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