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2. Esophago-jejunal anastomosis with open approach using the parachute technique to prioritize safety after resection of esophagogastric junction cancer

Author

Higuchi, Tadashi, primary, Niihara, Masahiro, additional, Minoura, Hiroyuki, additional, Harada, Hiroki, additional, Chuman, Motohiro, additional, Washio, Marie, additional, Sakuraya, Mikiko, additional, Kumagai, Koshi, additional, Kumamoto, Yusuke, additional, Naitoh, Takeshi, additional, Yamashita, Keishi, additional, and Hiki, Naoki, additional

Published
2024
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5. CAF-associated genes putatively representing distinct prognosis by in silico landscape of stromal components of colon cancer

Author

Okuno, Kota, primary, Ikemura, Kyonosuke, additional, Okamoto, Riku, additional, Oki, Keiko, additional, Watanabe, Akiko, additional, Kuroda, Yu, additional, Kidachi, Mikiko, additional, Fujino, Shiori, additional, Nie, Yusuke, additional, Higuchi, Tadashi, additional, Chuman, Motohiro, additional, Washio, Marie, additional, Sakuraya, Mikiko, additional, Niihara, Masahiro, additional, Kumagai, Koshi, additional, Sangai, Takafumi, additional, Kumamoto, Yusuke, additional, Naitoh, Takeshi, additional, Hiki, Naoki, additional, and Yamashita, Keishi, additional

Published
2024
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10. Neoadjuvant chemotherapy plus surgery for high-risk advanced gastric cancer: long-term results of KDOG1001 trial

Author

Hosoda, Kei, Katada, Chikatoshi, Ishido, Kenji, Niihara, Masahiro, Ushiku, Hideki, Sakuraya, Mikiko, Washio, Marie, Wada, Takuya, Watanabe, Akinori, Harada, Hiroki, Sato, Takeo, Tajima, Hiroshi, Kaizu, Takashi, Kosaka, Yoshimasa, Kato, Hiroshi, Sengoku, Norihiko, Tanaka, Kiyoshi, Naito, Takeshi, Kumamoto, Yusuke, Sangai, Takafumi, Tanabe, Satoshi, Koizumi, Wasaburo, Yamashita, Keishi, and Hiki, Naoki

Published
2020
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13. Comprehensive Exploration to Identify Predictive DNA Markers of ΔNp63/SOX2 in Drug Resistance in Human Esophageal Squamous Cell Carcinoma

Author

Ooizumi, Yosuke, Kojima, Keita, Igarashi, Kazuharu, Tanaka, Yoko, Harada, Hiroki, Yokota, Kazuko, Kaida, Takeshi, Ishii, Satoru, Tanaka, Toshimichi, Yokoi, Keigo, Nishizawa, Nobuyuki, Washio, Marie, Ushiku, Hideki, Katoh, Hiroshi, Kosaka, Yoshimasa, Mieno, Hiroaki, Hosoda, Kei, Watanabe, Masahiko, Katada, Chikatoshi, Hiki, Naoki, and Yamashita, Keishi

Published
2019
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14. A phase II study of neoadjuvant chemotherapy with docetaxel, cisplatin, and S-1, followed by gastrectomy with D2 lymph node dissection for high-risk advanced gastric cancer: results of the KDOG1001 trial

Author

Hosoda, Kei, Azuma, Mizutomo, Katada, Chikatoshi, Moriya, Hiromitsu, Mieno, Hiroaki, Ishido, Kenji, Ema, Akira, Ushiku, Hideki, Wada, Takuya, Washio, Marie, Watanabe, Akinori, Higuchi, Katsuhiko, Tanabe, Satoshi, Koizumi, Wasaburo, Watanabe, Masahiko, and Yamashita, Keishi

Published
2019
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21. Haploinsufficiency by minute MutL homolog 1 promoter DNA methylation may represent unique phenotypes of microsatellite instability-gastric carcinogenesis

Author

Harada, Hiroki, primary, Nie, Yusuke, additional, Araki, Ippeita, additional, Soeno, Takafumi, additional, Chuman, Motohiro, additional, Washio, Marie, additional, Sakuraya, Mikiko, additional, Ushiku, Hideki, additional, Niihara, Masahiro, additional, Hosoda, Kei, additional, Kumamoto, Yusuke, additional, Naitoh, Takeshi, additional, Sangai, Takafumi, additional, Hiki, Naoki, additional, and Yamashita, Keishi, additional

Published
2021
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22. Prospective study to validate the clinical utility of DNA diagnosis of peritoneal fluid cytology test in gastric cancer

Author

Harada, Hiroki, primary, Soeno, Takafumi, additional, Nishizawa, Nobuyuki, additional, Washio, Marie, additional, Sakuraya, Mikiko, additional, Ushiku, Hideki, additional, Niihara, Masahiro, additional, Hosoda, Kei, additional, Kumamoto, Yusuke, additional, Naitoh, Takeshi, additional, Sangai, Takafumi, additional, Hiki, Naoki, additional, and Yamashita, Keishi, additional

Published
2021
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24. The incidences of metachronous multiple gastric cancer after various types of gastrectomy: analysis of data from a nationwide Japanese survey

Author

Kinami, Shinichi, primary, Aizawa, Masaki, additional, Yamashita, Hiroharu, additional, Kumagai, Koshi, additional, Kamiya, Satoshi, additional, Toda, Makoto, additional, Takahata, Takaomi, additional, Fujisaki, Muneharu, additional, Miyamoto, Hiroshi, additional, Kusanagi, Hiroshi, additional, Kobayashi, Kenta, additional, Washio, Marie, additional, Hosoda, Kei, additional, and Kosaka, Takeo, additional

Published
2020
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25. Neoadjuvant chemotherapy plus surgery for high-risk advanced gastric cancer: Long-term results of KDOG1001 trial.

Author

Hosoda, Kei, primary, Azuma, Mizutomo, additional, Katada, Chikatoshi, additional, Ishido, Kenji, additional, Niihara, Masahiro, additional, Ushiku, Hideki, additional, Sakuraya, Mikiko, additional, Washio, Marie, additional, Wada, Takuya, additional, Watanabe, Akinori, additional, Koizumi, Wasaburo, additional, Tanabe, Satoshi, additional, Yamashita, Keishi, additional, and Hiki, Naoki, additional

Published
2020
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28. Cancer-specific promoter DNA methylation of Cysteine dioxygenase type 1 (CDO1) gene as an important prognostic biomarker of gastric cancer

Author

Harada, Hiroki, primary, Hosoda, Kei, additional, Moriya, Hiromitsu, additional, Mieno, Hiroaki, additional, Ema, Akira, additional, Ushiku, Hideki, additional, Washio, Marie, additional, Nishizawa, Nobuyuki, additional, Ishii, Satoru, additional, Yokota, Kazuko, additional, Tanaka, Yoko, additional, Kaida, Takeshi, additional, Soeno, Takafumi, additional, Kosaka, Yoshimasa, additional, Watanabe, Masahiko, additional, and Yamashita, Keishi, additional

Published
2019
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29. Delta‐shaped anastomosis vs circular stapler anastomosis after laparoscopic distal gastrectomy with Billroth I reconstruction: A randomized controlled trial.

Author

Hosoda, Kei, Mieno, Hiroaki, Ema, Akira, Ushiku, Hideki, Washio, Marie, Song, Ildae, Watanabe, Masahiko, Yamashita, Keishi, and Hiki, Naoki

Subjects
STAPLERS (Surgery), GASTROENTEROSTOMY, RANDOMIZED controlled trials, GASTRECTOMY, SURGICAL complications, CLINICAL trial registries, POSTOPERATIVE pain
Abstract

Introduction: The aim of this study is to evaluate the efficacy of delta‐shaped anastomosis compared to circular stapler anastomosis in laparoscopic distal gastrectomy with Billroth I reconstruction. Methods: This is a single‐center randomized controlled study. Eligibility criteria included histologically proven gastric adenocarcinoma in the lower third of the stomach, clinical stage I tumor. Patients were preoperatively randomized to circular stapler anastomosis or delta‐shaped anastomosis. The primary endpoint is the number of analgesics used during three days after surgery. We compared the surgical outcomes of the two groups. Postoperative quality of life was evaluated using the Postgastrectomy Syndrome Assessment Scale‐45. This trial was registered at the UMIN Clinical Trials Registry as UMIN000025160. Results: Between December 2016 and September 2018, 39 patients (delta‐shaped anastomosis 18, circular stapler anastomosis 21) were enrolled. There was no difference in the number of analgesics used during three days after surgery (median nine: delta‐shaped anastomosis vs nine: circular stapler anastomosis, P =.91). There was no difference in the overall proportion with in‐hospital grade II–IIIB surgical complications (11%: delta‐shaped anastomosis, 14%: circular stapler anastomosis). There was no operation‐related death in either arm. Regarding postoperative quality of life evaluated one month after surgery, diarrhea subscale was significantly worse in delta‐shaped anastomosis than in circular stapler anastomosis. Conclusion: We did not demonstrate the advantage of delta‐shaped anastomosis in terms of postoperative pain. Since delta‐shaped anastomosis tended to cause postoperative abdominal symptoms related to diarrhea, we should carefully apply the delta‐shaped anastomosis to laparoscopic distal gastrectomy with Billroth I reconstruction. [ABSTRACT FROM AUTHOR]

Published
2020
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31. A phase II study of neoadjuvant chemotherapy with docetaxel, cisplatin, and S-1, followed by gastrectomy with D2 lymph node dissection for high-risk advanced gastric cancer: results of the KDOG1001 trial

Author

Hosoda, Kei, primary, Azuma, Mizutomo, additional, Katada, Chikatoshi, additional, Moriya, Hiromitsu, additional, Mieno, Hiroaki, additional, Ishido, Kenji, additional, Ema, Akira, additional, Ushiku, Hideki, additional, Wada, Takuya, additional, Washio, Marie, additional, Watanabe, Akinori, additional, Higuchi, Katsuhiko, additional, Tanabe, Satoshi, additional, Koizumi, Wasaburo, additional, Watanabe, Masahiko, additional, and Yamashita, Keishi, additional

Published
2018
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33. Patients’ preoperative background causes gastric stasis after laparoscopy-assisted pylorus-preserving gastrectomy

Author

Nishizawa, Nobuyuki, primary, Hosoda, Kei, additional, Moriya, Hiromitsu, additional, Mieno, Hiroaki, additional, Ema, Akira, additional, Ushiku, Hideki, additional, Ishii, Satoru, additional, Tanaka, Toshimichi, additional, Washio, Marie, additional, Yokoi, Keigo, additional, Harada, Hiroki, additional, Watanabe, Masahiko, additional, and Yamashita, Keishi, additional

Published
2018
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38. The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios

Author

Ishii, Satoru, primary, Yamashita, Keishi, additional, Harada, Hiroki, additional, Ushiku, Hideki, additional, Tanaka, Toshimichi, additional, Nishizawa, Nobuyuki, additional, Yokoi, Keigo, additional, Washio, Marie, additional, Ema, Akira, additional, Mieno, Hiroaki, additional, Moriya, Hiromitsu, additional, Hosoda, Kei, additional, Waraya, Mina, additional, Katoh, Hiroshi, additional, and Watanabe, Masahiko, additional

Published
2017
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40. A Prognostic Analysis of Esophageal Squamous Cell Carcinoma in a Prospective Database Determined by Integrative Treatment Strategy Based on an Esophageal Cancer Board

Author

Harada, Hiroki, primary, Yamashita, Keishi, additional, Hosoda, Kei, additional, Moriya, Hiromitsu, additional, Mieno, Hiroaki, additional, Ema, Akira, additional, Washio, Marie, additional, Katada, Chikatoshi, additional, Komori, Shoko, additional, and Watanabe, Masahiko, additional

Published
2017
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42. Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E-box-binding homeobox 1 expression.

Author

Harada, Hiroki, Hosoda, Kei, Moriya, Hiromitsu, Mieno, Hiroaki, Ema, Akira, Washio, Marie, Kikuchi, Mariko, Kosaka, Yoshimasa, Watanabe, Masahiko, and Yamashita, Keishi

Subjects
ESOPHAGEAL tumors, CARCINOSARCOMAS, TUMOR surgery, TRANSCRIPTION factors, SQUAMOUS cell carcinoma, ZINC-finger proteins
Abstract

Esophageal carcinosarcoma (ECS) has been suggested to result from an epithelial mesenchymal transition (EMT) phenomenon. However, knowledge on its underlying molecular features is limited. The clinical and pathological features, and the prognosis of ECS require further investigation. In the present study, a total of 325 patients with esophageal tumors were observed between January 2004 and December 2014, of which 6 patients were diagnosed pathologically with ECS. The clinicopathological features were compared with those of corresponding cases with the identical pathological T stage (pT) of esophageal squamous cell carcinoma (ESCC). In terms of the clinical T stage (cT), the 6 cases were composed of cT1, cT2, cT3 and cT4 in 1, 1, 3 and 1 case, respectively. Nevertheless, pT was eventually diagnosed as pT1 in all cases. There was a large discrepancy between clinically diagnosed depth of tumor invasion prior to surgery and depth of tumor invasion following surgery. Zinc finger E-box-binding homeobox 1 (ZEB1), an EMT-associated transcription factor, was expressed only in the sarcoma component in all 6 cases of ECS. The ECS cases had a significantly poorer prognosis compared with the 115 pT1 ESCC cases. The present study suggests that the depth of invasion of ECS lesions does not correspond with their respective size, and the EMT of the carcinoma component may affect the prognosis by overexpression of the ZEB1 gene. [ABSTRACT FROM AUTHOR]

Published
2019

43. Esophagogastric junction cancer successfully treated by laparoscopic proximal gastrectomy and lower esophagectomy with intrathoracic double‐flap technique: A case report.

Author

Hosoda, Kei, Yamashita, Keishi, Moriya, Hiromitsu, Washio, Marie, Mieno, Hiroaki, Ema, Akira, and Watanabe, Masahiko

Subjects
ESOPHAGOGASTRIC junction cancer, ESOPHAGECTOMY, ESOPHAGEAL surgery, GASTRECTOMY, ENDOSCOPIC surgery, LAPAROSCOPIC surgery, SURGICAL complications
Abstract

Abstract: A 66‐year‐old man was referred to our hospital for treatment of esophagogastric junction cancer. He was diagnosed as cT2N0M0, and the esophageal invasion was found to be 1 cm from the esophagogastric junction. He underwent laparoscopy‐assisted proximal gastrectomy and lower esophagectomy with esophagogastrostomy using the intrathoracic double‐flap technique through the transhiatal approach. The operative time was 662 min (suturing time was 198 min), and blood loss was 200 mL. The operative time was much longer for this procedure than for esophagogastrostomy with the conventional (intra‐abdominal) double‐flap technique. The postoperative course was uneventful. No abnormal gastroesophageal reflux, esophageal motility, or lower esophageal sphincter (LES) pressure was demonstrated 3 months after the operation. Laparoscopic proximal gastrectomy and lower esophagectomy with esophagogastrostomy using the double‐flap technique through the transhiatal approach is safe and feasible. It may be recommended for patients with esophagogastric junction cancer with esophageal invasion of about 1 cm. [ABSTRACT FROM AUTHOR]

Published
2018
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44. Prognostic relevance of FGFR2 expression in stage II/III gastric cancer with curative resection and S-1 chemotherapy.

Author

Hosoda, Kei, Yamashita, Keishi, Ushiku, Hideki, Ema, Akira, Moriya, Hiromitsu, Mieno, Hiroaki, Washio, Marie, and Watanabe, Masahiko

Subjects
STOMACH cancer treatment, FIBROBLAST growth factor receptors, CANCER chemotherapy, IMMUNOHISTOCHEMISTRY, CANCER relapse
Abstract

Curative gastrectomy and adjuvant chemotherapy using S-1 is a standard treatment for stage II/III gastric cancer in Japan. The purpose of the present study was to evaluate the prognostic relevance of fibroblast growth factor receptor (FGFR)2 expression in patients with stage II/III gastric cancer that underwent postoperative adjuvant chemotherapy with S-1. Formalin-fixed paraffin-embedded surgical specimens were retrospectively examined in 167 patients with stage II/III gastric cancer that underwent curative gastrectomy followed by adjuvant S1 chemotherapy. FGFR2 expression was measured using immunohistochemistry (IHC) staining. The IHC results for FGFR2 were as follows: Grade 1+, 32; grade 2+, 80; grade 3+, 55 patients. The FGFR2 expression level was not significantly associated with relapse-free or overall survival rates. However, in the diffuse type, the FGFR2 expression level tended to be negatively correlated with relapse-free survival. In particular, the proportion of patients who recurred >5 years following surgery was significantly larger in the FGFR2 grade 3+ group than in the grade 1+, 2+ group (4/22 vs. 1/35; P=0.047). The recurrent sites of long-term failure were mostly peritoneum among the diffuse type. To the best of our knowledge, the present study indicated for the first time that FGFR2 could predict long-term failure of adjuvant S-1 chemotherapy in curative advanced gastric cancer. There was no interaction between FGFR2 expression and patient survival outcomes in stage II/III gastric cancer. Patients with FGFR2 3+ in stage II/III gastric cancer should carefully be followed-up for >5 years after surgery. [ABSTRACT FROM AUTHOR]

Published
2018
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45. Prognoses of advanced esophago-gastric junction cancer may be modified by thoracotomy and splenectomy.

Author

Hosoda, Kei, Yamashita, Keishi, Tsuruta, Harukazu, Moriya, Hiromitsu, Mieno, Hiroaki, Ema, Akira, Washio, Marie, and Watanabe, Masahiko

Subjects
ESOPHAGOGASTRIC junction cancer, THORACOTOMY, SPLENECTOMY, TUMORS, CANCER diagnosis, MULTIVARIATE analysis, PATIENTS, THERAPEUTICS
Abstract

Globally, the incidence of esophago-gastric junction (EGJ) cancer is rapidly increasing. However, the proposed strategies for the treatment of these types of cancer are so diverse that there is no established consensus on the optimal treatment. The aim of the present study was to identify independent prognostic factors to delineate the optimal strategies for the treatment of EGJ cancer. The medical records of 150 patients with EGJ cancer who underwent curative surgery at the Kitasato University were retrospectively reviewed. The median follow-up period was 48 months. The patients with tumors that were classified as post-treatment primary tumor stage 3 [(y)pT3] or higher had a 5-year disease-specific survival (DSS) rate of 53%, whereas those with tumors that were classified as (y)pT0-2 had a 5-year DSS rate of 90%. Therefore, prognostic analysis was restricted to those tumors that were designated (y)pT3 or higher. A multivariate Cox's proportional hazards model identified the following independent prognostic factors that negatively influenced the DSS: i) Presence of tumors classified as post-treatment regional lymph node stage 1-3 [(y)pN1-3] [hazard ratio (HR), 3.62; 95% confidence interval (CI), 1.39-12.36]; ii) not undergoing treatment with splenectomy (HR, 2.40; 95% CI, 1.15-5.15); and iii) undergoing treatment with thoracotomy (HR, 2.07; 95% CI, 1.02-4.23). In patients with (y)pN0 tumors, the DSS rate was significantly improved for those who underwent splenectomy than for those who did not (P=0.024). In patients with (y)pN1-3 tumors, the DSS rate was significantly worse for those who underwent thoracotomy compared with those who did not (P=0.004). Splenectomy and thoracotomy may critically affect prognosis in locally advanced EGJ cancer that are classified as (y)pN0 and (y)pN1-3, respectively. Surgical treatments require optimization in order to improve prognoses in advanced EGJ cancer. [ABSTRACT FROM AUTHOR]

Published
2018
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47. Individualized chemotherapy for colorectal cancer based on the collagen gel droplet-embedded drug sensitivity test

Author

OCHIAI, TAKUMI, primary, NISHIMURA, KAZUHIKO, additional, WATANABE, TOMOO, additional, KITAJIMA, MASAYUKI, additional, NAKATANI, AKINORI, additional, INOU, TAKASHI, additional, WASHIO, MARIE, additional, SAKUYAMA, NAOKI, additional, SATO, TSUYOSHI, additional, KISHINE, KENJI, additional, OCHI, TAKANORI, additional, OKUBO, SATOSHI, additional, FUTAGAWA, SHUNJI, additional, MASHIKO, SATOMI, additional, and NAGAOKA, ISAO, additional

Published
2012
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48. Serum iron levels as new predictive factor in FOLFOX/FOLFIRI with or without molecularly targeted drug therapy.

Author

Ochiai, Takumi, primary, Nishimura, Kazuhiko, additional, Watanabe, Tomoo, additional, Kitajima, Masayuki, additional, Nakatani, Akinori, additional, Inou, Takashi, additional, Sakuyama, Naoki, additional, Washio, Marie, additional, Kishine, Kennji, additional, Sato, Tsuyoshi, additional, Ochi, Takanori, additional, Okubo, Satoshi, additional, Futagawa, Shunji, additional, and Nagaoka, Isao, additional

Published
2012
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