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2. The utility of DNA methylation analysis in elderly patients with pilocytic astrocytoma morphology

Author

Suruga, Yasuki, Satomi, Kaishi, Otani, Yoshihiro, Fujii, Kentaro, Ishida, Joji, Uneda, Atsuhito, Tsuboi, Nobushige, Makino, Keigo, Hirano, Shuichiro, Kemmotsu, Naoya, Imoto, Ryoji, Mizuta, Ryo, Tomita, Yusuke, Yasuhara, Takao, Washio, Kana, Yanai, Hiroyuki, Matsushita, Yuko, Hibiya, Yuko, Yoshida, Akihiko, Capper, David, Ichimura, Koichi, and Date, Isao

Published
2022
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4. Delayed diagnostic interval and survival outcomes in pediatric leukemia: A single‐center, retrospective study.

Author

Tamefusa, Kosuke, Ochi, Motoharu, Ishida, Hisashi, Shiwaku, Takahiro, Kanamitsu, Kiichiro, Fujiwara, Kaori, Tatebe, Yasuhisa, Matsumoto, Naomi, Washio, Kana, and Tsukahara, Hirokazu

Subjects
SURVIVAL rate, LEUKEMIA, LOG-rank test, CHILD patients, BIOLOGICAL classification
Abstract

Objective: This study primarily focused on the diagnostic interval (DI), defined as the duration from the onset of leukemic symptoms to diagnosis. We investigated whether a prolonged DI is associated with the outcomes of pediatric leukemia. Methods: We retrospectively collected data of children with newly diagnosed pediatric leukemia at Okayama University Hospital from January 2007 to December 2022. Survival analyses were conducted using Kaplan–Meier methods, and an unadjusted analysis to compare differences in survival was performed using the log‐rank test. Results: In total, 103 children with leukemia were included in the analysis. The median DI was 20 days (interquartile range, 9.5–33.5 days). A prolonged DI (≥30 days) demonstrated no association with either 5‐year event‐free survival (70.1% for <30 days and 68.3% for ≥30 days, p =.99, log‐rank test) or overall survival (84.7% for <30 days and 89.4% for ≥30 days, p =.85, log‐rank test). Conclusions: A prolonged DI was not associated with the survival of children with leukemia. If a precise classification of leukemia biology is provided for pediatric patients, a prolonged DI may have little impact on the prognosis of these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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5. 10206-GGE-21 MOLECULAR LANDSCAPE AND TUMOR EVOLUTION IN ASTROBLASTOMA

Author

Yamamoto, Ryo, primary, Nakashima, Takuma, additional, Sugihara, Yuriko, additional, Funakoshi, Yusuke, additional, Goto, Hironori, additional, Ushida, Eri, additional, Yamasaki, Kai, additional, Yamasaki, Fumiyuki, additional, Gomi, Akira, additional, Arakawa, Yoshiki, additional, Washio, Kana, additional, Tateishi, Kensuke, additional, Suzuki, Tomonari, additional, Saito, Ryuta, additional, Narita, Yoshitaka, additional, Nobusawa, Sumihito, additional, and Suzuki, Hiromichi, additional

Published
2023
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7. Utility of Comprehensive Genomic Profiling for Precise Diagnosis of Pediatric-Type Diffuse High-Grade Glioma

Author

Makino, Keigo, Otani, Yoshihiro, Fujii, Kentaro, Ishida, Joji, Hirano, Shuichiro, Suruga, Yasuki, Washio, Kana, Nishida, Kenji, Yanai, Hiroyuki, Tomida, Shuta, Ennishi, Daisuke, and Date, Isao

Subjects
genome-wide DNA methylation, comprehensive genomic profiling, pediatric brain tumor, MYCN
Abstract

In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.

Published
2023

8. Optimizing transplantation procedures through identification of prognostic factors in second remission for children with acute myeloid leukemia with no prior history of transplant

Author

Ishida, Hisashi, primary, Tsujimoto, Shin-ichi, additional, Hasegawa, Daisuke, additional, Sakaguchi, Hirotoshi, additional, Yamamoto, Shohei, additional, Yanagimachi, Masakatsu, additional, Koh, Katsuyoshi, additional, Watanabe, Akihiro, additional, Hama, Asahito, additional, Cho, Yuko, additional, Watanabe, Kenichiro, additional, Noguchi, Maiko, additional, Takeuchi, Masanobu, additional, Takita, Junko, additional, Washio, Kana, additional, Kato, Keisuke, additional, Koike, Takashi, additional, Hashii, Yoshiko, additional, Tabuchi, Ken, additional, Hino, Moeko, additional, Atsuta, Yoshiko, additional, and Okamoto, Yasuhiro, additional

Published
2023
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10. High rates of ovarian function preservation after hematopoietic cell transplantation with melphalan-based reduced intensity conditioning for pediatric acute leukemia: an analysis from the Japan Association of Childhood Leukemia Study (JACLS)

Author

Fujino, Hisanori, Ishida, Hiroyuki, Iguchi, Akihiro, Onuma, Masaei, Kato, Koji, Shimizu, Mariko, Yasui, Masahiro, Fujisaki, Hiroyuki, Hamamoto, Kazuko, Washio, Kana, Sakaguchi, Hirotoshi, Miyashita, Emiko, Osugi, Yuko, Nakagami-Yamaguchi, Etsuko, Hayakawa, Akira, Sato, Atsushi, Takahashi, Yoshiyuki, and Horibe, Keizo

Published
2019
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12. Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch

Author

Kondo, Takumi, primary, Fujii, Keiko, additional, Fujii, Nobuharu, additional, Sumii, Yuichi, additional, Urata, Tomohiro, additional, Kimura, Maiko, additional, Matsuda, Masayuki, additional, Ikegawa, Shuntaro, additional, Washio, Kana, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Matsuoka, Ken‐ichi, additional, Otsuka, Fumio, additional, and Maeda, Yoshinobu, additional

Published
2023
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15. Prognostic Factors in Children with Acute Myeloid Leukemia Receiving the First Hematopoietic Stem Cell Transplantation in Second Remission

Author

Ishida, Hisashi, primary, Tsujimoto, Shin-ichi, additional, Hasegawa, Daisuke, additional, Sakaguchi, Hirotoshi, additional, Yamamoto, Shohei, additional, Yanagimachi, Masakatsu, additional, Koh, Katsuyoshi, additional, Watanabe, Akihiro, additional, Hama, Asahito, additional, Cho, Yuko, additional, Watanabe, Kenichiro, additional, Noguchi, Maiko, additional, Takeuchi, Masanobu, additional, Takita, Junko, additional, Washio, Kana, additional, Hashii, Yoshiko, additional, Tabuchi, Ken, additional, Hino, Moeko, additional, Atsuta, Yoshiko, additional, and Okamoto, Yasuhiro, additional

Published
2022
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16. Low‐dose acyclovir for prophylaxis of varicella‐zoster virus reactivation after hematopoietic stem cell transplantation in children

Author

Tatebe, Yasuhisa, primary, Ushio, Soichiro, additional, Esumi, Satoru, additional, Sada, Hikaru, additional, Ochi, Motoharu, additional, Tamefusa, Kosuke, additional, Ishida, Hisashi, additional, Fujiwara, Kaori, additional, Kanamitsu, Kiichiro, additional, Washio, Kana, additional, Katsube, Risa, additional, Murakawa, Kiminaka, additional, and Zamami, Yoshito, additional

Published
2022
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17. Red blood cell depletion in small‐volume bone marrow processing using manipulation with third‐party red blood cells: A comparison of the performance of the COBE spectra and the spectra Optia systems

Author

Sumii, Yuichi, primary, Fujii, Nobuharu, additional, Fujii, Keiko, additional, Kondo, Takumi, additional, Urata, Tomohiro, additional, Kimura, Maiko, additional, Washio, Kana, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Matsuoka, Ken‐ichi, additional, Otsuka, Fumio, additional, and Maeda, Yoshinobu, additional

Published
2022
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19. Additional file 1 of Neonatal hemochromatosis with εγδβ-thalassemia: a case report and analysis of serum iron regulators

Author

Tsuge, Mitsuru, Kodera, Aya, Sumitomo, Hiromi, Araki, Tooru, Yoshida, Ryuichi, Yasui, Kazuya, Sato, Hiroki, Washio, Yosuke, Washio, Kana, Shigehara, Kenji, Yashiro, Masato, Yagi, Takahito, and Tsukahara, Hirokazu

Abstract

Additional file 1: Table S1. Sixty-one genes in the analysis for the hereditary disorders associated with neonatal and infancy cholestasis.

Published
2022
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20. Registry data analysis of hematopoietic stem cell transplantation on systemic chronic active Epstein–Barr virus infection patients in Japan

Author

Yamamoto, Masahide, primary, Sato, Maho, additional, Onishi, Yasushi, additional, Sasahara, Yoji, additional, Sano, Hideki, additional, Masuko, Masayoshi, additional, Nakamae, Hirohisa, additional, Matsuoka, Ken‐ichi, additional, Ara, Takahide, additional, Washio, Kana, additional, Onizuka, Makoto, additional, Watanabe, Kenichiro, additional, Takahashi, Yoshiyuki, additional, Hirakawa, Tsuneaki, additional, Nishio, Miwako, additional, Sakashita, Chizuko, additional, Kobayashi, Tohru, additional, Sawada, Akihisa, additional, Ichinohe, Tatsuo, additional, Fukuda, Takahiro, additional, Hashii, Yoshiko, additional, Atsuta, Yoshiko, additional, and Arai, Ayako, additional

Published
2022
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21. Low hematocrit reduces the efficiency of CD34 + cell collection when using the Spectra Optia continuous mononuclear cell collection procedure

Author

Kondo, Takumi, primary, Fujii, Nobuharu, additional, Fujii, Keiko, additional, Sumii, Yuichi, additional, Urata, Tomohiro, additional, Kimura, Maiko, additional, Matsuda, Masayuki, additional, Ikegawa, Shuntaro, additional, Washio, Kana, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Matsuoka, Ken‐ichi, additional, Otsuka, Fumio, additional, and Maeda, Yoshinobu, additional

Published
2022
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26. Neonatal hemochromatosis with epsilon gamma delta beta-thalassemia: a case report and analysis of serum iron regulators

Author

Tsuge, Mitsuru, Kodera, Aya, Sumitomo, Hiromi, Araki, Tooru, Yoshida, Ryuichi, Yasui, Kazuya, Sato, Hiroki, Washio, Yosuke, Washio, Kana, Shigehara, Kenji, Yashiro, Masato, Yagi, Takahito, and Tsukahara, Hirokazu

Subjects
Liver transplantation, Case report, Hepcidin, Neonatal hemochromatosis, Thalassemia, Growth differentiation factor-15, Gestational alloimmune liver disease, Ineffective erythropoiesis
Abstract

Background Neonatal hemochromatosis causes acute liver failure during the neonatal period, mostly due to gestational alloimmune liver disease (GALD). Thalassemia causes hemolytic anemia and ineffective erythropoiesis due to mutations in the globin gene. Although neonatal hemochromatosis and thalassemia have completely different causes, the coexistence of these diseases can synergistically exacerbate iron overload. We report that a newborn with epsilon gamma delta beta-thalassemia developed neonatal hemochromatosis, which did not respond to iron chelators and rapidly worsened, requiring living-donor liver transplantation. Case presentation A 1-day-old Japanese boy with hemolytic anemia and targeted red blood cells was diagnosed with epsilon gamma delta beta-thalassemia by genetic testing, and required frequent red blood cell transfusions. At 2 months after birth, exacerbation of jaundice, grayish-white stool, and high serum ferritin levels were observed, and liver biopsy showed iron deposition in hepatocytes and Kupffer cells. Magnetic resonance imaging scans showed findings suggestive of iron deposits in the liver, spleen, pancreas, and bone marrow. The total amount of red blood cell transfusions administered did not meet the criteria for post-transfusion iron overload. Administration of an iron-chelating agent was initiated, but iron overload rapidly progressed to liver failure without improvement in jaundice and liver damage. He underwent living-donor liver transplantation from his mother, after which iron overload disappeared, and no recurrence of iron overload was observed. Immunohistochemical staining for C5b-9 in the liver was positive. Serum hepcidin levels were low and serum growth differentiation factor-15 levels were high prior to living-donor liver transplantation. Conclusions We reported that an infant with epsilon gamma delta beta-thalassemia developed NH due to GALD, and that coexistence of ineffective erythropoiesis in addition to erythrocyte transfusions may have exacerbated iron overload. Low serum hepcidin levels, in this case, might have been caused by decreased hepcidin production arising from fetal liver damage due to neonatal hemochromatosis and increased hepcidin-inhibiting hematopoietic mediators due to the ineffective hematopoiesis observed in thalassemia.

Published
2022

27. The Outcomes of Systemic Chronic Active EBV Infection Treatment By Allogeneic Hematopoietic Stem Cell Transplantation: An Analysis of Japanese Registry Data

Author

Arai, Ayako, primary, Yamamoto, Masahide, additional, Sato, Maho, additional, Onishi, Yasushi, additional, Sasahara, Yoji, additional, Sano, Hideki, additional, Masuko, Masayoshi, additional, Nakamae, Hirohisa, additional, Matsuoka, Ken-Ichi, additional, Ara, Takahide, additional, Washio, Kana, additional, Onizuka, Makoto, additional, Watanabe, Kenichiro, additional, Hirakawa, Tsuneaki, additional, Nishio, Miwako, additional, Sakashita, Chizuko, additional, Kobayashi, Tohru, additional, Sawada, Akihisa, additional, Ichinohe, Tatsuo, additional, Fukuda, Takahiro, additional, Hashii, Yoshiko, additional, and Atsuta, Yoshiko, additional

Published
2021
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31. Long-term Remission of Hepatitis-associated Aplastic Anemia Possibly due to Immunosuppressive Therapy after Liver Transplantation

Author

Kanamitsu, Kiichiro, Chayama, Kousuke, Washio, Kana, Yoshida, Ryuichi, Umeda, Yuzo, Yagi, Takahito, and Shimada, Akira

Subjects
surgical procedures, operative, liver transplantation, immunosuppressive therapy, hepatitis-associated aplastic anemia, impaired hematopoiesis, abnormal immune reaction
Abstract

Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living-donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient’s bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis.

Published
2018

33. Low hematocrit reduces the efficiency of CD34+ cell collection when using the Spectra Optia continuous mononuclear cell collection procedure.

Author

Kondo, Takumi, Fujii, Nobuharu, Fujii, Keiko, Sumii, Yuichi, Urata, Tomohiro, Kimura, Maiko, Matsuda, Masayuki, Ikegawa, Shuntaro, Washio, Kana, Fujiwara, Hideaki, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Matsuoka, Ken‐ichi, Otsuka, Fumio, and Maeda, Yoshinobu

Abstract

Background: CD34+ cell collection efficiency (CE) is the determining factor when calculating processed blood volume (PBV) for leukapheresis (LP). However, the factors affecting CE in the continuous mononuclear cell collection (cMNC) protocol performed by the Spectra Optia apheresis system are not well established. Study Design and Methods: We retrospectively collected the data from 147 consecutive apheresis procedures across 106 healthy donors and 27 patients completed between July 2016 and December 2020 at the Okayama University Hospital. All procedures were performed using the Optia cMNC protocol. Results: The median CD34+ CE2 was significantly higher in the donor samples (64.3%) than in the patient samples (46.8%) (p <.0001). WBC counts, hematocrit, and platelet counts were all significantly higher in the donors than in the patients, and there was a moderate positive correlation between CD34+ CE2 and hematocrit (r =.47, p <.0001), with the equation of the line being y = 1.23x + 12.23. In contrast, there was only a very weak correlation between CD34+ CE2 and WBC or platelet count. In addition, low hematocrit correlated with an increased time to interface formation. Conclusion: These data revealed the negative impact of low hematocrit on the efficiency of CD34+ cell collection when using the Optia cMNC protocol and suggest that hematocrit values should also be considered when determining PBV. [ABSTRACT FROM AUTHOR]

Published
2022
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39. IMMUNOHISTOCHEMICAL ANALYSES OF PTPN6 (SHP1) IN LANGERHANS CELL HISTIOCYTOSIS

Author

Murakami, Ichiro, Oka, Takashi, Sato, Hiaki, Morito, Toshiaki, Takata, Katsuyoshi, Shinno, Yoko, Takano, Masayuki, Washio, Kana, Ko, Shingo, Tamura, Maiko, Ohnishi, Naoko, Ichimura, Koichi, Sato, Yasuharu, Yanai, Hiroyuki, Ohara, Nobuya, Kondo, Eisaku, Takahashi, Kiyoshi, Tanaka, Takehiro, Gogusev, Jean, Jaubert, Francis, Morimoto, Akira, Imashuku, Shinsaku, Akagi, Tadaatsu, and Yoshino, Tadashi

Published
2009

42. High-grade glioneuronal tumor with an ARHGEF2–NTRK1 fusion gene

Author

Kurozumi, Kazuhiko, primary, Nakano, Yoshiko, additional, Ishida, Joji, additional, Tanaka, Takehiro, additional, Doi, Masatomo, additional, Hirato, Junko, additional, Yoshida, Akihiko, additional, Washio, Kana, additional, Shimada, Akira, additional, Kohno, Takashi, additional, Ichimura, Koichi, additional, Yanai, Hiroyuki, additional, and Date, Isao, additional

Published
2019
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44. Panel-based next-generation sequencing identifies prognostic and actionable genes in childhood acute lymphoblastic leukemia and is suitable for clinical sequencing

Author

Ishida, Hisashi, primary, Iguchi, Akihiro, additional, Aoe, Michinori, additional, Takahashi, Takahide, additional, Tamefusa, Kosuke, additional, Kanamitsu, Kiichiro, additional, Fujiwara, Kaori, additional, Washio, Kana, additional, Matsubara, Takehiro, additional, Tsukahara, Hirokazu, additional, Sanada, Masashi, additional, and Shimada, Akira, additional

Published
2018
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45. Sorafenib treatment for papillary thyroid carcinoma with diffuse lung metastases in a child with autism spectrum disorder: a case report

Author

Higuchi, Yousuke, primary, Motoki, Takayuki, additional, Ishida, Hisashi, additional, Kanamitsu, Kiichiro, additional, Washio, Kana, additional, Oyama, Takanori, additional, Noda, Takuo, additional, Tsurumaru, Yasuko, additional, Okada, Ayumi, additional, Tsukahara, Hirokazu, additional, and Shimada, Akira, additional

Published
2017
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47. Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia

Author

Washio, Kana, primary, Oka, Takashi, additional, Abdalkader, Lamia, additional, Muraoka, Michiko, additional, Shimada, Akira, additional, Oda, Megumi, additional, Sato, Hiaki, additional, Takata, Katsuyoshi, additional, Kagami, Yoshitoyo, additional, Shimizu, Norio, additional, Kato, Seiichi, additional, Kimura, Hiroshi, additional, Nishizaki, Kazunori, additional, Yoshino, Tadashi, additional, and Tsukahara, Hirokazu, additional

Published
2017
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50. Sorafenib treatment for papillary thyroid carcinoma with diffuse lung metastases in a child with autism spectrum disorder: a case report.

Author

Gkika, Eleni, Hallauer, Lukas, Kirste, Simon, Adebahr, Sonja, Bartl, Nico, Neeff, Hannes Philipp, Fritsch, Ralph, Brass, Volker, Nestle, Ursula, Grosu, Anca Ligia, Brunner, Thomas Baptist, Higuchi, Yousuke, Motoki, Takayuki, Ishida, Hisashi, Kanamitsu, Kiichiro, Washio, Kana, Oyama, Takanori, Noda, Takuo, Tsurumaru, Yasuko, and Okada, Ayumi

Subjects
AUTISM spectrum disorders, THYROID cancer treatment, LUNG cancer, SORAFENIB, IODINE isotopes, HOSPITAL care, THERAPEUTICS
Abstract

Background: Pediatric papillary thyroid carcinoma frequently presents with lymph node involvement and distant metastases. Sorafenib, an oral multikinase inhibitor, has been used to treat radioactive iodine (RAI) therapy-refractory thyroid carcinoma in adults; however, pediatric experience is limited. Medical procedures and hospitalization for children with autism spectrum disorder may be challenging.Case Presentation: An 11-year-old boy with autism spectrum disorder and moderate intellectual impairment presented with dyspnea on exertion with thyroid carcinoma and diffuses lung metastases. Total thyroidectomy and adjuvant RAI therapy is the standard treatment; however, the latter therapy was impractical because of his respiratory status and challenging behaviors. He was therefore started on sorafenib 200 mg/day (150 mg/m2/day) and this dosage was increased to 400 mg/day (300 mg/m2/day). The adverse effects were mild and tolerable. After administration of medication, his dyspnea improved and surgery was performed. We attempted to administer RAI therapy after surgery; however, we abandoned it because he had difficulty taking care of himself according to isolation room rules. Thyrotropin suppression therapy was therefore started and sorafenib treatment (400 mg/day) resumed. Follow-up imaging showed regression of pulmonary metastases. The metastases have remained stable for over 24 months on continuous sorafenib treatment without serious adverse events.Conclusion: We inevitably used sorafenib as an alternative to standard therapy because of the patient's specific circumstances. Individualized strategies for pediatric cancer patients with autism spectrum disorder are needed. [ABSTRACT FROM AUTHOR]

Published
2017
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