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11 results on '"Warwick, Helen K."'

2. The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

Author

Riddell, David R., Zhou, Hua, Comery, Thomas A., Kouranova, Evguenia, Lo, C. Frederick, Warwick, Helen K., Ring, Robert H., Kirksey, Yolanda, Aschmies, Suzan, Xu, Jane, Kubek, Katie, Hirst, Warren D., Gonzales, Catherine, Chen, Yi, Murphy, Erin, Leonard, Sarah, Vasylyev, Dmytro, Oganesian, Aram, Martone, Robert L., Pangalos, Menelas N., Reinhart, Peter H., and Jacobsen, J. Steve

Published
2007
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6. Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

Author

Riddell, David R., primary, Zhou, Hua, additional, Atchison, Kevin, additional, Warwick, Helen K., additional, Atkinson, Peter J., additional, Jefferson, Julius, additional, Xu, Lin, additional, Aschmies, Suzan, additional, Kirksey, Yolanda, additional, Hu, Yun, additional, Wagner, Erik, additional, Parratt, Adrienne, additional, Xu, Jane, additional, Li, Zhuting, additional, Zaleska, Margaret M., additional, Jacobsen, J. Steve, additional, Pangalos, Menelas N., additional, and Reinhart, Peter H., additional

Published
2008
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7. P1‐072: Upregulated expression of cholesterol‐related genes in the Tg2576 model of Alzheimer's disease

Author

Warwick, Helen K., primary, Saraf, Kathryn, additional, Zhong, Wenyan, additional, von Schack, David, additional, Comery, Tom, additional, Aschmies, Suzan, additional, Li, Zhuting, additional, Monaghan, Michael, additional, Ring, Robert, additional, Pangalos, Menelas, additional, Reinhart, Peter, additional, and Riddell, David, additional

Published
2008
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9. Group I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to cyclic AMP response element binding protein (CREB) through a common Ca2+- and protein kinase C-dependent pathway.

Author

Warwick, Helen K., Nahorski, Stefan R., and Challiss, R. A. John

Subjects
*NEUROTRANSMITTER receptors, *CYCLIC adenylic acid, *CARRIER proteins, *PROTEIN kinase C, *PHOSPHORYLATION, *CHEMICAL reactions, *NEUROCHEMISTRY
Abstract

Coupling of the group I metabotropic glutamate receptors, mGlu1a and mGlu5a, to the cAMP response element binding protein (CREB) has been studied in Chinese hamster ovary cell lines where receptor expression is under the control of an inducible promoter. Both receptors stimulate CREB phosphorylation with similar time courses, and agonist potency was also comparable between the two receptors. Stimulation of cells in Ca2+-free medium containing EGTA (100 μm), with or without the additional depletion of intracellular stores, caused marked decreases in agonist-mediated responses in both cell lines. Down-regulation of protein kinase C (PKC) activity by phorbol ester treatment, or treatment with the broad spectrum PKC inhibitor Ro 31–8220, partially attenuated both mGlu1a and mGlu5a receptor-mediated responses. Furthermore, stimulation of cells in the absence of extracellular Ca2+ following prior PKC down-regulation resulted in additive inhibitory effects. The involvement of extracellular signal-regulated kinases (ERK1/2), Ca2+/calmodulin or Ca2+/calmodulin-dependent protein kinases was assessed using pharmacological inhibitors. Results indicated that coupling of the group I mGlu receptors to CREB phosphorylation occurs independently of these pathways. Thus, although the[Ca2+]i signatures activated by these mGlu receptors differ, they couple to CREB with comparable potency and recruit similar downstream components to execute CREB phosphorylation. [ABSTRACT FROM AUTHOR]

Published
2005
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